diazoxide has been researched along with Alloxan Diabetes in 42 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of glucagon suppression by somatostatin upon endogenous hyperglycemia was studied in three forms of experimental insulin deficiency in dogs: alloxan diabetes, total pancreatectomy, and diazoxide administration." | 7.65 | The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus. ( Dobbs, RE; Sakurai, H; Unger, RH, 1975) |
| "To induce acute hyperglycemia, diazoxide, a selective, ATP-sensitive K(+) channel opener was used." | 3.77 | Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly. ( Abrahani, A; Kim, MS; Puthanveetil, P; Rodrigues, B; Wang, F; Wang, Y, 2011) |
| "The effect of glucagon suppression by somatostatin upon endogenous hyperglycemia was studied in three forms of experimental insulin deficiency in dogs: alloxan diabetes, total pancreatectomy, and diazoxide administration." | 3.65 | The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus. ( Dobbs, RE; Sakurai, H; Unger, RH, 1975) |
| "Suppression of pancreatic glucagon secretion by hyperglycemia is a characteristic of normal alpha cell function." | 3.65 | The effect of experimental insulin deficiency on glucagon secretion. ( Faloona, GR; Müller, WA; Unger, RH, 1971) |
| "Diazoxide treatment (30 mg/kg/d, intragastrically) for 28 days accelerated wound closure and stimulated angiogenesis in the diabetic mice." | 1.43 | Diazoxide accelerates wound healing by improving EPC function. ( Deng, YP; Jiang, GJ; Li, DJ; Li, ZP; Shen, FM; Xin, RJ; Yang, H, 2016) |
| "Eight weeks after type 1 diabetes induction, DZ preconditioned, and non-preconditioned DM-EPCs were transplanted into left ventricle of diabetic rats (at a dose of 2 × 10(6) DM-EPCs/70 μl serum free medium)." | 1.42 | Diazoxide preconditioning of endothelial progenitor cells from streptozotocin-induced type 1 diabetic rats improves their ability to repair diabetic cardiomyopathy. ( Ali, M; Anjum, MS; Khan, SN; Mehmood, A; Riazuddin, S; Tarrar, MN, 2015) |
| "Diazoxide treatment significantly decreased the body weight (P<0." | 1.36 | [Effect of K-ATP channel opener diazoxide on islet cell apoptosis and the expressions of apoptosis-related genes]. ( Wang, HF; Xu, J; Zhang, W, 2010) |
| "Diazoxide treatment increased by 5." | 1.31 | Treatment with diazoxide causes prolonged improvement of beta-cell function in rat islets transplanted to a diabetic environment. ( Grill, V; Hiramatsu, S; Höög, A; Möller, C, 2000) |
| "Hyperglycemia is an important predictor of cardiovascular mortality in patients with diabetes." | 1.31 | Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels. ( Ghassemi, T; Gross, ER; Kersten, JR; Montgomery, MW; Pagel, PS; Toller, WG; Warltier, DC, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (28.57) | 18.7374 |
| 1990's | 12 (28.57) | 18.2507 |
| 2000's | 5 (11.90) | 29.6817 |
| 2010's | 12 (28.57) | 24.3611 |
| 2020's | 1 (2.38) | 2.80 |
| Authors | Studies |
|---|---|
| Vargas-Vargas, MA | 1 |
| Saavedra-Molina, A | 1 |
| Gómez-Barroso, M | 1 |
| Peña-Montes, D | 1 |
| Cortés-Rojo, C | 1 |
| Rodríguez-Orozco, AR | 1 |
| Rocío, MP | 1 |
| Ma, Z | 1 |
| Moruzzi, N | 1 |
| Catrina, SB | 1 |
| Hals, I | 1 |
| Oberholzer, J | 1 |
| Grill, V | 2 |
| Björklund, A | 1 |
| Chan, O | 1 |
| Paranjape, SA | 1 |
| Horblitt, A | 1 |
| Zhu, W | 1 |
| Sherwin, RS | 1 |
| Ogata, H | 1 |
| Seino, Y | 1 |
| Harada, N | 1 |
| Iida, A | 1 |
| Suzuki, K | 1 |
| Izumoto, T | 1 |
| Ishikawa, K | 1 |
| Uenishi, E | 1 |
| Ozaki, N | 1 |
| Hayashi, Y | 1 |
| Miki, T | 1 |
| Inagaki, N | 1 |
| Tsunekawa, S | 1 |
| Hamada, Y | 1 |
| Seino, S | 1 |
| Oiso, Y | 1 |
| Ali, M | 1 |
| Mehmood, A | 1 |
| Anjum, MS | 1 |
| Tarrar, MN | 1 |
| Khan, SN | 1 |
| Riazuddin, S | 1 |
| Li, ZP | 1 |
| Xin, RJ | 1 |
| Yang, H | 1 |
| Jiang, GJ | 1 |
| Deng, YP | 1 |
| Li, DJ | 1 |
| Shen, FM | 1 |
| Jašová, M | 1 |
| Kancirová, I | 1 |
| Muráriková, M | 1 |
| Farkašová, V | 1 |
| Waczulíková, I | 1 |
| Ravingerová, T | 1 |
| Ziegelhöffer, A | 1 |
| Ferko, M | 1 |
| Huang, CW | 1 |
| Wu, SN | 1 |
| Cheng, JT | 1 |
| Tsai, JJ | 1 |
| Huang, CC | 1 |
| Han, JS | 1 |
| Yan, DM | 1 |
| Zhu, HY | 1 |
| Wang, ZW | 1 |
| Luo, P | 1 |
| Chang, HH | 1 |
| Zhou, Y | 1 |
| Zhang, S | 1 |
| Hwang, SH | 1 |
| Morisseau, C | 1 |
| Wang, CY | 1 |
| Inscho, EW | 1 |
| Hammock, BD | 1 |
| Wang, MH | 1 |
| Xu, J | 1 |
| Wang, HF | 1 |
| Zhang, W | 1 |
| Wang, Y | 2 |
| Puthanveetil, P | 2 |
| Wang, F | 2 |
| Kim, MS | 1 |
| Abrahani, A | 2 |
| Rodrigues, B | 2 |
| Chen, ZC | 1 |
| Cheng, YZ | 1 |
| Chen, LJ | 1 |
| Cheng, KC | 1 |
| Li, Y | 1 |
| Cheng, J | 1 |
| Zhang, D | 1 |
| Wan, A | 1 |
| del Valle, HF | 1 |
| Lascano, EC | 1 |
| Negroni, JA | 1 |
| Matsuda, M | 1 |
| Kawasaki, F | 1 |
| Mikami, Y | 1 |
| Takeuchi, Y | 1 |
| Saito, M | 1 |
| Eto, M | 1 |
| Kaku, K | 1 |
| Anderson, J | 1 |
| Coulson, R | 1 |
| Tomlinson, RW | 1 |
| Jori, A | 1 |
| Bianchetti, A | 1 |
| Leahy, JL | 1 |
| Bumbalo, LM | 1 |
| Chen, C | 1 |
| Westermark, G | 1 |
| Arora, MB | 1 |
| Fox, N | 1 |
| Carroll, R | 1 |
| Chan, SJ | 1 |
| Westermark, P | 1 |
| Steiner, DF | 1 |
| Jones, RB | 1 |
| Dickinson, K | 1 |
| Anthony, DM | 1 |
| Marita, AR | 1 |
| Kaul, CL | 1 |
| Buckett, WR | 1 |
| Gray, AM | 1 |
| Flatt, PR | 1 |
| Bouskela, E | 1 |
| Cyrino, FZ | 1 |
| Conde, CM | 1 |
| Garcia, AA | 1 |
| Guillot, E | 1 |
| Coste, A | 1 |
| Eon, MT | 1 |
| Angel, I | 1 |
| Mahmoudian, M | 1 |
| Mirkhani, H | 1 |
| Pelé-Tounian, A | 1 |
| Chan, SL | 1 |
| Rondu, F | 1 |
| Le Bihan, G | 1 |
| Giroix, MH | 1 |
| Lamouri, A | 1 |
| Touboul, E | 1 |
| Pfeiffer, B | 1 |
| Manechez, D | 1 |
| Renard, P | 1 |
| Guardiola-Lemaître, B | 1 |
| Godfroid, JJ | 1 |
| Pénicaud, L | 1 |
| Morgan, NG | 1 |
| Ktorza, A | 1 |
| Hiramatsu, S | 1 |
| Höög, A | 1 |
| Möller, C | 1 |
| Kersten, JR | 1 |
| Montgomery, MW | 1 |
| Ghassemi, T | 1 |
| Gross, ER | 1 |
| Toller, WG | 1 |
| Pagel, PS | 1 |
| Warltier, DC | 1 |
| Sakurai, H | 1 |
| Dobbs, RE | 1 |
| Unger, RH | 2 |
| Sako, Y | 1 |
| Grill, VE | 1 |
| Ramirez, R | 2 |
| Sener, A | 1 |
| Malaisse, WJ | 2 |
| Kukuljan, M | 1 |
| Li, MY | 1 |
| Atwater, I | 1 |
| Zähner, D | 1 |
| Berger, MR | 1 |
| Fink, M | 1 |
| Feichter, GE | 1 |
| Janetschek, P | 1 |
| Bonkowsky, HL | 1 |
| Collins, A | 1 |
| Doherty, JM | 1 |
| Tschudy, DP | 1 |
| Losert, W | 1 |
| Senft, G | 1 |
| Sitt, R | 1 |
| Schultz, G | 1 |
| Kaess, H | 1 |
| Foy, JM | 1 |
| Furman, BL | 1 |
| Loubatières, A | 1 |
| Müller, WA | 1 |
| Faloona, GR | 1 |
| Söling, HD | 1 |
| Unger, KO | 1 |
| Staquet, M | 1 |
| Nabwangu, J | 1 |
| Wolff, F | 1 |
2 reviews available for diazoxide and Alloxan Diabetes
| Article | Year |
|---|---|
The control of glucagon secretion.
Topics: Adaptation, Physiological; Alanine; Animals; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Fasti | 1972 |
[Physiological and pharmacological aspects of the central role of the pancreas in the mode of action of hypoglycemic sulfonamides].
Topics: Action Potentials; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Drug An | 1969 |
40 other studies available for diazoxide and Alloxan Diabetes
| Article | Year |
|---|---|
Diazoxide improves muscle function in association with improved dyslipidemia and decreased muscle oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Cholesterol; Diabetes Mellitus, Experimental; Diazoxide; Hyperglycemia; Lipids; Mice; Muscl | 2023 |
Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic β-cells.
Topics: AMP-Activated Protein Kinases; Animals; Calcium; Calcium Channel Blockers; Cell Hypoxia; Cells, Cult | 2013 |
Lactate-induced release of GABA in the ventromedial hypothalamus contributes to counterregulatory failure in recurrent hypoglycemia and diabetes.
Topics: Animals; Bicuculline; Coumaric Acids; Diabetes Mellitus, Experimental; Diazoxide; GABA Antagonists; | 2013 |
KATP channel as well as SGLT1 participates in GIP secretion in the diabetic state.
Topics: Animals; Diabetes Mellitus, Experimental; Diazoxide; Gastric Inhibitory Polypeptide; Glucose; KATP C | 2014 |
Diazoxide preconditioning of endothelial progenitor cells from streptozotocin-induced type 1 diabetic rats improves their ability to repair diabetic cardiomyopathy.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Biomarkers; Blood Glucose; Cell Proliferation; Ce | 2015 |
Diazoxide accelerates wound healing by improving EPC function.
Topics: Animals; Apoptosis; Cell Proliferation; Diabetes Mellitus, Experimental; Diazoxide; Endothelial Cell | 2016 |
Stimulation of mitochondrial ATP synthase activity - a new diazoxide-mediated mechanism of cardioprotection.
Topics: Animals; Diabetes Mellitus, Experimental; Diazoxide; Heart Diseases; Male; Membrane Fluidity; Mitoch | 2016 |
Diazoxide reduces status epilepticus neuron damage in diabetes.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Blood Glucose; Cell Line, Transformed; Diabet | 2010 |
[Diabetes counteracts the protective effect of the diazoxide preconditioning on ischemic reperfused rat heart].
Topics: Animals; Diabetes Mellitus, Experimental; Diazoxide; In Vitro Techniques; Ischemic Preconditioning, | 2009 |
Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis.
Topics: Animals; Apoptosis; Benzoates; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Epoxide Hy | 2010 |
[Effect of K-ATP channel opener diazoxide on islet cell apoptosis and the expressions of apoptosis-related genes].
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Diabetes Mellitus, Experimental; Diazoxide; Islets o | 2010 |
Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Animals; Calnexin; Diabetes Mellitus, Experimental; Diaz | 2011 |
Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; ATP-Binding Cassette Transporters; | 2012 |
Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1.
Topics: Active Transport, Cell Nucleus; Animals; Apoptosis; Apoptosis Inducing Factor; Blood Glucose; Cell N | 2012 |
Ischemic preconditioning protection against stunning in conscious diabetic sheep: role of glucose, insulin, sarcolemmal and mitochondrial KATP channels.
Topics: Action Potentials; Analysis of Variance; Animals; Decanoic Acids; Diabetes Mellitus, Experimental; D | 2002 |
Rescue of beta-cell exhaustion by diazoxide after the development of diabetes mellitus in rats with streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Islets of Langerhans; Male; Rats | 2002 |
Hyperpyruvaturia in experimental diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diazoxide; Female; Glycosuria; Immune Sera; Insulin, Long- | 1967 |
Effect of benzyloxyguanidine (13958 RP) on the increase of blood glucose and plasma free fatty acids induced by various drugs in rats.
Topics: Animals; Blood Glucose; Body Temperature; Chlorpromazine; Diabetes Mellitus, Experimental; Diazoxide | 1967 |
Diazoxide causes recovery of beta-cell glucose responsiveness in 90% pancreatectomized diabetic rats.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diazoxide; Glucose; | 1994 |
Amyloid formation in response to beta cell stress occurs in vitro, but not in vivo, in islets of transgenic mice expressing human islet amyloid polypeptide.
Topics: Amyloid; Animals; Antihypertensive Agents; Aurothioglucose; Blood Glucose; Cells, Cultured; Cortison | 1995 |
Evaluation of BTS 67 582, a novel antidiabetic agent, in normal and diabetic rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Brain; Cromakalim; Diabetes Mellitus, Experime | 1997 |
Pancreatic and extra-pancreatic effects of the traditional anti-diabetic plant, Medicago sativa (lucerne).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antihypertensive Agents; Biological Transport; Culture Techniq | 1997 |
Microvascular permeability with sulfonylureas in normal and diabetic hamsters.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Capillary Permeability; Cricetinae; Dextrans; D | 1997 |
Mechanisms of the hypoglycemic effects of the alpha2-adrenoceptor antagonists SL84.0418 and deriglidole.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Chlor | 1998 |
Effect of diazoxide, an ATP-dependent potassium-channel opener, on isolated aortae of normal and diabetic rats.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Diabetes Mellitus, Experimental; Diazoxide; Glybu | 1998 |
Effect of the new imidazoline derivative S-22068 (PMS 847) on insulin secretion in vitro and glucose turnover in vivo in rats.
Topics: Animals; Antihypertensive Agents; Diabetes Mellitus, Experimental; Diazoxide; Glucose; Glucose Clamp | 1999 |
Treatment with diazoxide causes prolonged improvement of beta-cell function in rat islets transplanted to a diabetic environment.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diazoxide; Female; Hypoglycemi | 2000 |
Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels.
Topics: Analysis of Variance; Animals; Blood Glucose; Blood Pressure; Carbon Dioxide; Coronary Circulation; | 2001 |
The role of glucagon in the pathogenesis of the endogenous hyperglycemia of diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Glucagon; Hyperglycemia; P | 1975 |
Diazoxide infusion at excess but not at basal hyperglycemia enhances beta-cell sensitivity to glucose in vitro in neonatally streptozotocin-diabetic rats.
Topics: Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Glucose; In Vi | 1992 |
Assay of 3-hydroxybutyrate in the picomolar range.
Topics: 3-Hydroxybutyric Acid; Animals; Carbon Radioisotopes; Cattle; Diabetes Mellitus, Experimental; Diazo | 1991 |
Characterization of potassium channels in pancreatic beta cells from ob/ob mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Diazoxide; Electric Conductivity; Glucose | 1990 |
Kinetic behaviour of liver glucokinase in diabetes. III. Possible role of insulinopenia.
Topics: Acetylglucosamine; Animals; Blood Glucose; Cytosol; Diabetes Mellitus, Experimental; Diazoxide; Fema | 1990 |
Effects of diazoxide-induced reversible diabetes on chemically induced autochthonous mammary carcinomas in Sprague-Dawley rats.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide | 1985 |
The glucose effect in rat liver: studies of delta-aminolevulinate synthase and tyrosine aminotransferase.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Blood Glucose; Bucladesine; Cyclic A | 1973 |
[Participation of insulin in diazoxide hyperglycemia].
Topics: Adenosine Triphosphate; Adrenal Glands; Animals; Antihypertensive Agents; Diabetes Mellitus, Experim | 1966 |
Effect of single dose administration of diuretics on the blood sugar of alloxan-diabetic mice or mice made hyperglycaemic by the acute administration of diazoxide.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Diuresis; Diuretics; Drug Intera | 1973 |
The effect of experimental insulin deficiency on glucagon secretion.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diazoxide; Dogs; Glucagon; Heptoses; He | 1971 |
The role of insulin in the regulation of -amylase synthesis in the rat pancreas.
Topics: Adrenalectomy; Amino Sugars; Amylases; Animals; Anti-Bacterial Agents; Chymotrypsin; Dactinomycin; D | 1972 |
The effect of thiazides on the blood sugar of alloxanized and suballoxanized rats.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Diabetes Mellitus, Experimental; Diazoxide; Glucose | 1965 |