diazoxide has been researched along with Age-Related Memory Disorders in 4 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazoxide is a putative mitochondrial, ATP-sensitive potassium channel opener that has been implicated in neuroprotection in cerebral ischemia." | 3.73 | Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion. ( Bari, F; Domoki, F; Farkas, E; Luiten, PG; Mihály, A; Timmer, NM, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salgado-Puga, K | 1 |
| Rodríguez-Colorado, J | 1 |
| Prado-Alcalá, RA | 1 |
| Peña-Ortega, F | 1 |
| Liu, D | 1 |
| Pitta, M | 1 |
| Lee, JH | 1 |
| Ray, B | 1 |
| Lahiri, DK | 1 |
| Furukawa, K | 1 |
| Mughal, M | 1 |
| Jiang, H | 1 |
| Villarreal, J | 1 |
| Cutler, RG | 1 |
| Greig, NH | 1 |
| Mattson, MP | 1 |
| Farkas, E | 2 |
| Institóris, A | 1 |
| Domoki, F | 2 |
| Mihály, A | 2 |
| Luiten, PG | 2 |
| Bari, F | 2 |
| Timmer, NM | 1 |
4 other studies available for diazoxide and Age-Related Memory Disorders
| Article | Year |
|---|---|
Subclinical Doses of ATP-Sensitive Potassium Channel Modulators Prevent Alterations in Memory and Synaptic Plasticity Induced by Amyloid-β.
Topics: Amyloid beta-Peptides; Animals; Diazoxide; Hippocampus; KATP Channels; Male; Membrane Transport Modu | 2017 |
The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2010 |
Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion.
Topics: Animals; Astrocytes; Brain; Carotid Arteries; CD11b Antigen; Cerebrovascular Disorders; Cyclooxygena | 2004 |
Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion.
Topics: Animals; Brain Infarction; Brain Ischemia; Carotid Stenosis; CD11 Antigens; Cerebrovascular Circulat | 2005 |