diazoxide has been researched along with Acute Kidney Injury in 13 studies
Diazoxide: A benzothiadiazine derivative that is a peripheral vasodilator used for hypertensive emergencies. It lacks diuretic effect, apparently because it lacks a sulfonamide group.
diazoxide : A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 30 year-old male patient with accelerated arterial hypertension relatively resistent to diazoxide received a single oral dose of 100 mg of atenolol, following which hypotension of more than 24 hours duration and acute renal failure ensued." | 7.66 | [Prolonged hypotension after the first dose of atenolol (author's transl)]. ( Botey, A; Darnell, A; Montoliu, J; Revert, L, 1981) |
| " We examined KATP channel modulation in renal ischemia-reperfusion injury (IRI), using an isolated perfused rat kidney (IPRK) model, in control, IRI, IRI+200 microM diazoxide (a KATP opener), IRI + 10 microM glibenclamide (a KATP blocker) and IRI + 200 microM diazoxide + 10 microM glibenclamide groups." | 3.72 | ATP-dependent K+ channels in renal ischemia reperfusion injury. ( Endre, ZH; Gobé, GC; Rahgozar, M; Willgoss, DA, 2003) |
| "A 30 year-old male patient with accelerated arterial hypertension relatively resistent to diazoxide received a single oral dose of 100 mg of atenolol, following which hypotension of more than 24 hours duration and acute renal failure ensued." | 3.66 | [Prolonged hypotension after the first dose of atenolol (author's transl)]. ( Botey, A; Darnell, A; Montoliu, J; Revert, L, 1981) |
| "Cause of renal disease are chronic renal failure in three, acute renal failure in three, hemolytic uremic syndrome in two, acute post streptococcal glomerulonephritis in one, and renal arterial stenosis in a further patient." | 1.26 | [Hypertensive emergencies in children with renal hypertension (author's transl)]. ( Bachmann, HJ; Olbing, H; Pistor, K, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (84.62) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, L | 1 |
| Han, F | 1 |
| Mandal, A | 1 |
| Rao, GN | 1 |
| Zhang, X | 1 |
| Rahgozar, M | 1 |
| Willgoss, DA | 1 |
| Gobé, GC | 1 |
| Endre, ZH | 1 |
| Montoliu, J | 1 |
| Botey, A | 1 |
| Darnell, A | 1 |
| Revert, L | 1 |
| Leroux-Robert, C | 1 |
| Charmes, JP | 1 |
| Benevent, D | 1 |
| Rince, M | 1 |
| Bachmann, HJ | 1 |
| Olbing, H | 1 |
| Pistor, K | 1 |
| Diekmann, L | 1 |
| De Broe, M | 1 |
| Mussche, M | 1 |
| Bosteels, V | 1 |
| Fernandes, M | 1 |
| Kim, KE | 1 |
| Moyer, JH | 1 |
| Acchiardo, SR | 1 |
| Black, WD | 1 |
| Britt, L | 1 |
| McKeown, JW | 1 |
| Johnson, JG | 1 |
| Hatch, F | 1 |
| Sevitt, LH | 1 |
| Evans, DJ | 1 |
| Wrong, OM | 1 |
| Mathew, TH | 1 |
| Kincaid-Smith, P | 1 |
2 reviews available for diazoxide and Acute Kidney Injury
| Article | Year |
|---|---|
Diazoxide: a review of its pharmacological properties and therapeutic use in hypertensive crises.
Topics: Acute Kidney Injury; Animals; Blood Glucose; Cardiovascular Diseases; Cats; Cyclic AMP; Diazoxide; D | 1971 |
Hypertensive emergencies.
Topics: Acute Kidney Injury; Adrenal Gland Neoplasms; Antihypertensive Agents; Aortic Aneurysm; Blood Volume | 1974 |
11 other studies available for diazoxide and Acute Kidney Injury
| Article | Year |
|---|---|
Diazoxide attenuates hypothermic preservation-induced renal injury via down-regulation of CHOP and caspase-12.
Topics: Acute Kidney Injury; Animals; Apoptosis; Caspase 12; Cryoprotective Agents; Diazoxide; Disaccharides | 2010 |
ATP-dependent K+ channels in renal ischemia reperfusion injury.
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Cromakalim; Diazoxide; Disease Models, Animal; | 2003 |
[Prolonged hypotension after the first dose of atenolol (author's transl)].
Topics: Acute Kidney Injury; Adult; Atenolol; Diazoxide; Drug Synergism; Humans; Hypertension; Hypotension; | 1981 |
[Treatment of malignant arterial hypertension].
Topics: Acute Kidney Injury; Clonidine; Diazoxide; Dihydralazine; Diuretics; Humans; Hypertension, Malignant | 1980 |
[Hypertensive emergencies in children with renal hypertension (author's transl)].
Topics: Acute Disease; Acute Kidney Injury; Child; Child, Preschool; Diazoxide; Female; Glomerulonephritis; | 1979 |
[The acute crisis of blood pressure and its treatment in childhood (authors transl)].
Topics: Acute Disease; Acute Kidney Injury; Administration, Oral; Adolescent; Age Factors; Child; Diazoxide; | 1975 |
Oral diazoxide for malignant hypertension.
Topics: Acute Kidney Injury; Administration, Oral; Adult; Diabetic Ketoacidosis; Diazoxide; Female; Humans; | 1972 |
Editorial: Streptozotocin for islet-cell carcinoma.
Topics: Acute Kidney Injury; Adenoma, Islet Cell; Diabetes Insipidus; Diazoxide; Drug Evaluation; Humans; Hy | 1973 |
Experience with hemodialysis and renal transplantation in patients with malignant hypertension.
Topics: Acute Kidney Injury; Adult; Brain Diseases; Diazoxide; Diet Therapy; Female; Follow-Up Studies; Furo | 1974 |
Acute oliguric renal failure due to accelerated (malignant) hypertension.
Topics: Acute Kidney Injury; Adolescent; Adult; Antihypertensive Agents; Anuria; Blood Urea Nitrogen; Diazox | 1971 |
The use of diazoxide in hypertensive crises with particular reference to the control of hypertension in severe renal failure.
Topics: Acute Kidney Injury; Antihypertensive Agents; Blood Pressure; Depression, Chemical; Diazoxide; Femal | 1971 |