Compounds > diaziquone
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diaziquone and Colonic Neoplasms

diaziquone has been researched along with Colonic Neoplasms in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19905 (62.50)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Erickson, LC; Ewig, RA; Kohn, KW; Szmigiero, L1
Bedikian, AY; Bodey, GP; Karlin, DA; Korinek, J; Stroehlein, JR1
Moertel, CG; O'Connell, MJ; Rubin, J; Schutt, AJ; van Hazel, GA1
Butler, J; Gibson, NW; Hartley, JA; Ross, D; Siegel, D1
Gibson, NW; Pacheco, D; Reasor, M; Ross, D; Siegel, D; Thomas, DJ; Wierda, D1
Gibson, NW; Preusch, PC; Ross, D; Siegel, D1
Bender, JF; Erlichman, C; Grillo-López, J; Neidhart, JA; Robert, F; Velez-Garcia, E1
Baker, LH; Fletcher, WS; McCracken, JD; O'Bryan, RM; Shildt, R; Stephens, RL; Subramanian, VP1

Trials

1 trial(s) available for diaziquone and Colonic Neoplasms

ArticleYear
Phase II trial of diaziquone in patients with colon cancer.
    Cancer treatment reports, 1985, Volume: 69, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Aziridines; Azirines; Benzoquinones; Clinical Trials as Topic; Colonic Neoplasms; Drug Evaluation; Female; Hematologic Diseases; Humans; Male; Middle Aged

1985

Other Studies

7 other study(ies) available for diaziquone and Colonic Neoplasms

ArticleYear
DNA strand scission and cross-linking by diaziridinylbenzoquinone (diaziquone) in human cells and relation to cell killing.
    Cancer research, 1984, Volume: 44, Issue:10

    Topics: Animals; Antineoplastic Agents; Aziridines; Azirines; Benzoquinones; Cell Line; Cell Survival; Chemical Phenomena; Chemistry; Colonic Neoplasms; DNA; DNA, Neoplasm; Embryo, Mammalian; Female; Fibroblasts; Free Radicals; Humans; Kinetics; Leukemia L1210; Mice; Pregnancy; Tritium

1984
Phase II clinical evaluation of AZQ in colorectal cancer.
    American journal of clinical oncology, 1982, Volume: 5, Issue:5

    Topics: Adult; Aged; Antineoplastic Agents; Aziridines; Azirines; Benzoquinones; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Middle Aged; Neutropenia; Rectal Neoplasms; Thrombocytopenia

1982
A phase II study of aziridinylbenzoquinone (AZQ) in advanced large bowel carcinoma.
    American journal of clinical oncology, 1982, Volume: 5, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Aziridines; Azirines; Benzoquinones; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Humans; Leukopenia; Male; Middle Aged; Rectal Neoplasms; Thrombocytopenia

1982
Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity.
    Molecular pharmacology, 1992, Volume: 42, Issue:3

    Topics: Animals; Antineoplastic Agents; Aziridines; Benzoquinones; Colonic Neoplasms; DNA Damage; Humans; Liver; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Rats; Tumor Cells, Cultured

1992
Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma.
    Free radical research communications, 1990, Volume: 8, Issue:4-6

    Topics: Animals; Aziridines; Benzene; Benzoquinones; Biotransformation; Bone Marrow; Bone Marrow Cells; Chromatography, High Pressure Liquid; Colonic Neoplasms; Fibroblasts; Humans; Inactivation, Metabolic; Macrophages; Male; Mice; Mice, Inbred Strains; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Quinone Reductases; Quinones; Tumor Cells, Cultured

1990
Metabolism of diaziquone by NAD(P)H:(quinone acceptor) oxidoreductase (DT-diaphorase): role in diaziquone-induced DNA damage and cytotoxicity in human colon carcinoma cells.
    Cancer research, 1990, Nov-15, Volume: 50, Issue:22

    Topics: Animals; Antineoplastic Agents; Aziridines; Benzoquinones; Carcinoma; Cell Division; Chromatography, High Pressure Liquid; Colonic Neoplasms; Glutathione; Humans; In Vitro Techniques; Kinetics; Liver; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Quinone Reductases; Rats; Spectrum Analysis; Tumor Cells, Cultured

1990
Phase II trial of diaziquone in advanced large bowel carcinoma in previously treated and untreated patients: a Southwest Oncology Group Study.
    Cancer treatment reports, 1985, Volume: 69, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Aziridines; Azirines; Benzoquinones; Colonic Neoplasms; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Neutropenia; Thrombocytopenia

1985