diazinon has been researched along with Neuroblastoma in 6 studies
Diazinon: A cholinesterase inhibitor that is used as an organothiophosphorus insecticide.
diazinon : A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to assess the neurotoxicity of diazinon oxon (DZO), a major in vivo metabolite of the phosphorothionate insecticide diazinon (DZ), on differentiating mouse N2a neuroblastoma cells." | 7.75 | Diazinon oxon affects the differentiation of mouse N2a neuroblastoma cells. ( Flaskos, J; Hargreaves, AJ; Harris, W; Sachana, M; Sidiropoulou, E; Woldehiwet, Z, 2009) |
| "In previous work, the outgrowth of axon-like processes by differentiating mouse N2a neuroblastoma cells was shown to be inhibited by exposure to 10 microM diazinon." | 7.75 | Neuroprotection from diazinon-induced toxicity in differentiating murine N2a neuroblastoma cells. ( Flaskos, J; Hargreaves, AJ; Harris, W; Sachana, M, 2009) |
| "In previous work we showed that sub-lethal levels of diazinon inhibited neurite outgrowth in differentiating N2a neuroblastoma cells." | 7.75 | Proteomic analysis of differentiating neuroblastoma cells treated with sub-lethal neurite inhibitory concentrations of diazinon: identification of novel biomarkers of effect. ( Flaskos, J; Hargreaves, AJ; Harris, W; Sachana, M, 2009) |
| " NB2a neuroblastoma cells were grown in the presence of 25 microM diazinon for 8 weeks." | 7.72 | The effects of acute pesticide exposure on neuroblastoma cells chronically exposed to diazinon. ( Axelrad, JC; Howard, CV; McLean, WG, 2003) |
| "In previous work, the outgrowth of axon-like processes by differentiating mouse N2a neuroblastoma cells was shown to be inhibited by exposure to 10 microM diazinon." | 3.75 | Neuroprotection from diazinon-induced toxicity in differentiating murine N2a neuroblastoma cells. ( Flaskos, J; Hargreaves, AJ; Harris, W; Sachana, M, 2009) |
| " NB2a neuroblastoma cells were induced to differentiate in the presence of the OPs diazinon and chlorpyrifos, in combination with a commercial formulation (identified as Commercial Formulation 1) of the compounds and, independently, the components of that formulation." | 3.71 | Interactions between pesticides and components of pesticide formulations in an in vitro neurotoxicity test. ( Axelrad, JC; Howard, CV; McLean, WG, 2002) |
| "Neuroblastoma is primarily an embryonal tumor of infancy." | 2.82 | Pre-conceptional and prenatal exposure to pesticides and pediatric neuroblastoma. A meta-analysis of nine studies. ( Feulefack, J; Khan, A; Sergi, CM, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Khan, A | 1 |
| Feulefack, J | 1 |
| Sergi, CM | 1 |
| Sidiropoulou, E | 1 |
| Sachana, M | 3 |
| Flaskos, J | 3 |
| Harris, W | 3 |
| Hargreaves, AJ | 3 |
| Woldehiwet, Z | 1 |
| Axelrad, JC | 2 |
| Howard, CV | 2 |
| McLean, WG | 2 |
1 review available for diazinon and Neuroblastoma
| Article | Year |
|---|---|
Pre-conceptional and prenatal exposure to pesticides and pediatric neuroblastoma. A meta-analysis of nine studies.
Topics: Adolescent; Adult; Child; Child, Preschool; Diazinon; Female; Glycine; Humans; Infant; Infant, Newbo | 2022 |
5 other studies available for diazinon and Neuroblastoma
| Article | Year |
|---|---|
Diazinon oxon affects the differentiation of mouse N2a neuroblastoma cells.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Survival; Diazinon; Dose-Response Relationship | 2009 |
Neuroprotection from diazinon-induced toxicity in differentiating murine N2a neuroblastoma cells.
Topics: Analysis of Variance; Animals; Antibodies; Axons; Cell Differentiation; Cholinesterase Inhibitors; C | 2009 |
Proteomic analysis of differentiating neuroblastoma cells treated with sub-lethal neurite inhibitory concentrations of diazinon: identification of novel biomarkers of effect.
Topics: Actin Depolymerizing Factors; Animals; Biomarkers; Blotting, Western; Cell Differentiation; Cell Lin | 2009 |
The effects of acute pesticide exposure on neuroblastoma cells chronically exposed to diazinon.
Topics: Animals; Cells, Cultured; Diazinon; Dose-Response Relationship, Drug; Drug Combinations; Image Proce | 2003 |
Interactions between pesticides and components of pesticide formulations in an in vitro neurotoxicity test.
Topics: Animals; Biological Assay; Cell Line; Chlorpyrifos; Chrysanthemum cinerariifolium; Diazinon; Drug Sy | 2002 |