diazepinylbenzoic-acid and Diabetes-Mellitus

Topics: Adiponectin; Animals; Benzoates; Biphenyl Compounds; Diabetes Mellitus; Ethics, Medical; Genetic Predisposition to Disease; Humans; Intercellular Signaling Peptides and Proteins; Patient Care; Pharmacogenetics; Polymorphism, Single Nucleotide; Proteins; Receptors, Cytoplasmic and Nuclear; Transcription Factors

Several genes are implicated to be the cause for diabetes, such as genes of PPAR gamma (peroxisome proliferator-activated receptor-gamma), adiponectin, beta 3-adrenergic receptor, etc., and their polymorphisms may have significant impact on the treatment and prevention of diabetes. Detection and analysis of such susceptibility genes will provide an enormous benefit for the future tailor-made medicine of diabetes, which include choosing the most effective treatment policy for each individual and developing novel drugs based on the genetic information that are applicable for corresponding individuals. Tailor-made medicine will be an efficient tool for treatment and prevention of lifestyle diseases, especially type 2 diabetes, along with further identification of its disease-causing genes.

Topics: Acetates; Adiponectin; Benzoates; Biphenyl Compounds; Calpain; Diabetes Mellitus; Drug Design; Genetic Predisposition to Disease; Genome, Human; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Polymorphism, Genetic; Proteins; Receptors, Adrenergic, beta-3; Receptors, Cytoplasmic and Nuclear; Transcription Factors