diazepam has been researched along with Stroke in 13 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We found that a 3-day treatment with diazepam after acute cortical anterior circulation stroke prevents the occurrence of seizures in the first 3 months following stroke." | 9.41 | Treatment with Diazepam in Acute Stroke Prevents Poststroke Seizures: A Substudy of the EGASIS Trial. ( Aldenkamp, AP; Rouhl, RPW; van Oostenbrugge, RJ; van Raak, EPM; van Tuijl, JH, 2021) |
| "We tested whether diazepam, a GABA-ergic drug that also inhibits brain nitric monoxide formation, improves acute stroke prognosis." | 9.12 | Diazepam to improve acute stroke outcome: results of the early GABA-Ergic activation study in stroke trial. a randomized double-blind placebo-controlled trial. ( Hardy, E; Hilton, A; Kessels, A; Lodder, J; van Raak, L, 2006) |
| "Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming." | 7.81 | Comparison of intranasal and intravenous diazepam on status epilepticus in stroke patients: a retrospective cohort study. ( Gunshin, M; Inokuchi, R; Kitsuta, Y; Nakajima, S; Nakamura, K; Ohashi-Fukuda, N; Wada, T; Yahagi, N, 2015) |
| "We found that a 3-day treatment with diazepam after acute cortical anterior circulation stroke prevents the occurrence of seizures in the first 3 months following stroke." | 5.41 | Treatment with Diazepam in Acute Stroke Prevents Poststroke Seizures: A Substudy of the EGASIS Trial. ( Aldenkamp, AP; Rouhl, RPW; van Oostenbrugge, RJ; van Raak, EPM; van Tuijl, JH, 2021) |
| "We tested whether diazepam, a GABA-ergic drug that also inhibits brain nitric monoxide formation, improves acute stroke prognosis." | 5.12 | Diazepam to improve acute stroke outcome: results of the early GABA-Ergic activation study in stroke trial. a randomized double-blind placebo-controlled trial. ( Hardy, E; Hilton, A; Kessels, A; Lodder, J; van Raak, L, 2006) |
| "This review provides moderate-quality evidence that fails to support the use of GABA receptor agonists (chlormethiazole or diazepam) for the treatment of people with acute stroke." | 4.98 | Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. ( Liu, J; Wang, LN; Zhang, J, 2018) |
| "This review provides moderate-quality evidence that fails to support the use of GABA receptor agonists (chlormethiazole or diazepam) for the treatment of people with acute stroke." | 4.93 | Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. ( Ji, X; Liu, J; Ma, X; Wang, LN, 2016) |
| "This review does not provide the evidence to support the use of GABA receptor agonists (chlormethiazole or diazepam) for the treatment of patients with acute ischemic or hemorrhagic stroke." | 4.90 | Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. ( Liu, J; Wang, LN, 2014) |
| "This review does not provide the evidence to support the use of GABA receptor agonists (chlormethiazole or diazepam) for the treatment of patients with acute ischemic or hemorrhagic stroke." | 4.89 | Gamma aminobutyric acid (GABA) receptor agonists for acute stroke. ( Liu, J; Wang, LN, 2013) |
| "Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming." | 3.81 | Comparison of intranasal and intravenous diazepam on status epilepticus in stroke patients: a retrospective cohort study. ( Gunshin, M; Inokuchi, R; Kitsuta, Y; Nakajima, S; Nakamura, K; Ohashi-Fukuda, N; Wada, T; Yahagi, N, 2015) |
| " Etizolam was effective in reducing the pain for only about 30 minutes." | 3.77 | A case of thalamic pain successfully treated with Kampo medicine. ( Chino, A; Kasahara, Y; Namiki, T; Ogawa, K; Okamoto, H; Terasawa, K; Ueda, K, 2011) |
| "Although diazepam provides limited long term neuroprotection, it may be useful for expanding the therapeutic time window after stroke by delaying neuronal death." | 3.74 | Diazepam delays the death of hippocampal CA1 neurons following global ischemia. ( Corbett, D; Langdon, KD; Larsen, J, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 9 (69.23) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| van Tuijl, JH | 1 |
| van Raak, EPM | 1 |
| van Oostenbrugge, RJ | 1 |
| Aldenkamp, AP | 1 |
| Rouhl, RPW | 1 |
| Liu, J | 4 |
| Zhang, J | 1 |
| Wang, LN | 4 |
| Greifzu, F | 2 |
| Pielecka-Fortuna, J | 1 |
| Kalogeraki, E | 1 |
| Krempler, K | 1 |
| Favaro, PD | 1 |
| Schlüter, OM | 1 |
| Löwel, S | 2 |
| Stodieck, SK | 1 |
| Goetze, B | 1 |
| Schmidt, KF | 1 |
| Inokuchi, R | 1 |
| Ohashi-Fukuda, N | 1 |
| Nakamura, K | 1 |
| Wada, T | 1 |
| Gunshin, M | 1 |
| Kitsuta, Y | 1 |
| Nakajima, S | 1 |
| Yahagi, N | 1 |
| Ma, X | 1 |
| Ji, X | 1 |
| Lindsay, C | 1 |
| Kouzouna, A | 1 |
| Simcox, C | 1 |
| Pandyan, AD | 1 |
| Corbett, D | 1 |
| Larsen, J | 1 |
| Langdon, KD | 1 |
| Ueda, K | 1 |
| Namiki, T | 1 |
| Kasahara, Y | 1 |
| Chino, A | 1 |
| Okamoto, H | 1 |
| Ogawa, K | 1 |
| Terasawa, K | 1 |
| Lodder, J | 1 |
| van Raak, L | 1 |
| Hilton, A | 1 |
| Hardy, E | 1 |
| Kessels, A | 1 |
| Meador, KJ | 1 |
| Ray, PG | 1 |
| Day, LJ | 1 |
| Loring, DW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Neuromuscular Electrical Stimulation on Walking Ability and Quality of Life in Individuals With Chronic Stroke[NCT04673045] | 40 participants (Anticipated) | Interventional | 2021-02-02 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for diazepam and Stroke
| Article | Year |
|---|---|
Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.
Topics: Acute Disease; Chlormethiazole; Diazepam; Disorders of Excessive Somnolence; GABA Agonists; gamma-Am | 2018 |
Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.
Topics: Chlormethiazole; Diazepam; GABA Agonists; Humans; Neuroprotective Agents; Randomized Controlled Tria | 2013 |
Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.
Topics: Acute Disease; Chlormethiazole; Diazepam; Disorders of Excessive Somnolence; GABA Agonists; Humans; | 2014 |
Gamma aminobutyric acid (GABA) receptor agonists for acute stroke.
Topics: Acute Disease; Chlormethiazole; Diazepam; Disorders of Excessive Somnolence; GABA Agonists; Humans; | 2016 |
Pharmacological interventions other than botulinum toxin for spasticity after stroke.
Topics: Baclofen; Botulinum Toxins, Type A; Clonidine; Diazepam; Humans; Muscle Relaxants, Central; Muscle S | 2016 |
2 trials available for diazepam and Stroke
| Article | Year |
|---|---|
Treatment with Diazepam in Acute Stroke Prevents Poststroke Seizures: A Substudy of the EGASIS Trial.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain; Brain Waves; Diazepam; Double-Blind Method; | 2021 |
Diazepam to improve acute stroke outcome: results of the early GABA-Ergic activation study in stroke trial. a randomized double-blind placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Brain Infarction; Cerebral Hemorrhage; Diazepam; Double-Blind Method | 2006 |
6 other studies available for diazepam and Stroke
| Article | Year |
|---|---|
Environmental enrichment extends ocular dominance plasticity into adulthood and protects from stroke-induced impairments of plasticity.
Topics: Animals; Diazepam; Dominance, Ocular; Environment; Female; GABA Modulators; Ibuprofen; Interneurons; | 2014 |
Brief dark exposure restored ocular dominance plasticity in aging mice and after a cortical stroke.
Topics: Aging; Animals; Contrast Sensitivity; Darkness; Diazepam; Dominance, Ocular; Female; Male; Mice; Mic | 2014 |
Comparison of intranasal and intravenous diazepam on status epilepticus in stroke patients: a retrospective cohort study.
Topics: Administration, Intranasal; Administration, Intravenous; Aged; Aged, 80 and over; Anticonvulsants; D | 2015 |
Diazepam delays the death of hippocampal CA1 neurons following global ischemia.
Topics: Animals; Anticonvulsants; Body Temperature; Brain Ischemia; Cell Count; Diazepam; Excitatory Postsyn | 2008 |
A case of thalamic pain successfully treated with Kampo medicine.
Topics: Aged; Analgesics; Diazepam; Female; Humans; Infarction; Medicine, Kampo; Movement Disorders; Nausea; | 2011 |
Train duration effects on perception: sensory deficit, neglect, and cerebral lateralization.
Topics: Adjuvants, Anesthesia; Adult; Aged; Anesthetics, Local; Brain; Bupivacaine; Consciousness; Diazepam; | 2000 |