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diazepam and Spinal Cord Injuries

diazepam has been researched along with Spinal Cord Injuries in 24 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).

Research Excerpts

ExcerptRelevanceReference
"The possibility that diazepam will influence spinal cord evoked potentials (SCEP), edema formation and cell changes following spinal cord injury (SCI) was examined in a rat model."3.69Benzodiazepine receptors influence spinal cord evoked potentials and edema following trauma to the rat spinal cord. ( Sharma, HS; Stålberg, E; Westman, J; Winkler, T, 1997)
"The effects of diazepam on reflex pathways in patients having complete spinal lesions and in patients having incomplete lesions of the spinal cord or multiple sclerosis are compared to determine whether diazepam has an action at spinal level."3.65Diazepam effect on reflex activity in patients with complete spinal lesions and in those with other causes of spasticity. ( Ashby, P; MacLeod, S; Verrier, M, 1977)
"The intensity of spasticity was measured electromyographically by the amplitude of the stretch reflex at various velocities, and the results were correlated with those obtained by clinical assessment."2.63A new agent for the control of spasticity. ( Burke, D; Gillies, JD; Jones, RF; Marosszeky, JE, 1970)
"Diazepam 20 mg was used up to three times per day, but didn't seem to improve or reduce the anxiety, agitation, visual or auditory hallucinations."1.48Delirium tremens in an AUD patient after an intrathecal baclofen pump induced total alcohol abstinence. ( Calvo, ME; Gunnarsson, T; Hao, M; Smith, L, 2018)
"Case series evaluating spasticity using clinical scales commonly referenced in contemporary literature, including the Penn Spasm Frequency Scale, the Ashworth Scale, and standard scales of tendon taps, clonus, and plantar stimulation."1.29Clinical assessment of spasticity in spinal cord injury: a multidimensional problem. ( Kharas, NF; Markowski, J; Priebe, MM; Sherwood, AM; Thornby, JI, 1996)
"Spinal cord seizures are infrequently reported."1.28Spinal cord seizures: a possible cause of isolated myoclonic activity in traumatic spinal cord injury: case report. ( Cross, LL; Meythaler, JM; Tuel, SM, 1991)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199015 (62.50)18.7374
1990's7 (29.17)18.2507
2000's0 (0.00)29.6817
2010's2 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, KH1
Aulakh, KS1
Liu, C1
Calvo, ME1
Gunnarsson, T1
Smith, L1
Hao, M1
Roberts, MH1
Wright, V1
Delaney, JF1
Frisbie, JH1
Aguilera, EJ1
Xiao-Jun, X1
Jing-Xia, H1
Seiger, Å1
Hughes, J1
Hökfelt, T1
Wiesenfeld-Hallin, Z1
Priebe, MM1
Sherwood, AM1
Thornby, JI1
Kharas, NF1
Markowski, J1
Broderick, CP1
Radnitz, CL1
Bauman, WA1
Winkler, T2
Sharma, HS2
Stålberg, E2
Westman, J2
Badgaiyan, RD1
Alm, P1
Yalla, SV1
Di Benedetto, M1
Blunt, KJ1
Sethi, JM1
Fam, BA1
Verrier, M3
Ashby, P3
MacLeod, S3
Meythaler, JM1
Tuel, SM1
Cross, LL1
Glass, A1
Hannah, A1
Cartlidge, NE1
Hudgson, P1
Weightman, D1
Jones, RF1
Burke, D1
Marosszeky, JE1
Gillies, JD1
Corbett, M1
Frankel, HL1
Michaelis, L1
Giménez Roldán, S1
Martínez Fuertes, L1
Avila, J1
Nakano, N1
Goto, K1
Neill, RW1
DeJak, JJ1
Lowry, R1

Trials

3 trials available for diazepam and Spinal Cord Injuries

ArticleYear
A comparison of dantrolene sodium and diazepam in the treatment of spasticity.
    Paraplegia, 1974, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Dantrolene; Diazepam;

1974
A new agent for the control of spasticity.
    Journal of neurology, neurosurgery, and psychiatry, 1970, Volume: 33, Issue:4

    Topics: Amines; Clinical Trials as Topic; Diazepam; Electromyography; Humans; Muscle Spasticity; Muscle Tonu

1970
A double blind, cross-over trial of Valium in the treatment of spasticity.
    Paraplegia, 1972, Volume: 10, Issue:1

    Topics: Amobarbital; Diazepam; Evaluation Studies as Topic; Female; Humans; Male; Muscle Spasticity; Placebo

1972

Other Studies

21 other studies available for diazepam and Spinal Cord Injuries

ArticleYear
Retrospective evaluation of prazosin and diazepam after thoracolumbar hemilaminectomy in dogs.
    Veterinary journal (London, England : 1997), 2019, Volume: 253

    Topics: Adjuvants, Anesthesia; Animals; Diazepam; Dog Diseases; Dogs; Female; Intervertebral Disc Displaceme

2019
Delirium tremens in an AUD patient after an intrathecal baclofen pump induced total alcohol abstinence.
    European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:16

    Topics: Alcohol Abstinence; Alcohol Drinking; Alcohol Withdrawal Delirium; Alcoholism; Baclofen; Diazepam; H

2018
Drugs or physical therapy in rehabilitation?
    International rehabilitation medicine, 1983, Volume: 5, Issue:1

    Topics: Analgesics; Baclofen; Dantrolene; Diazepam; Humans; Physical Therapy Modalities; Rheumatic Diseases;

1983
Medical treatment of spasticity.
    Current problems in surgery, 1980, Volume: 17, Issue:4

    Topics: Baclofen; Dantrolene; Diazepam; Humans; Injections, Spinal; Mephenesin; Muscle Relaxants, Central; M

1980
Diazepam and body weight in myelopathy patients.
    The journal of spinal cord medicine, 1995, Volume: 18, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Mi

1995
Chronic pain-related behaviors in spinally injured rats: evidence for functional alterations of the endogenous cholecystokinin and opioid systems.
    Pain, 1994, Volume: 56, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cholecystokinin; Chronic Disease; Diazepam; Endorphi

1994
Clinical assessment of spasticity in spinal cord injury: a multidimensional problem.
    Archives of physical medicine and rehabilitation, 1996, Volume: 77, Issue:7

    Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Baclofen; Diazepam; Female; Humans; Male

1996
Diazepam usage in veterans with spinal cord injury.
    The journal of spinal cord medicine, 1997, Volume: 20, Issue:4

    Topics: Baclofen; Data Collection; Diazepam; Hospitals, Veterans; Humans; Muscle Relaxants, Central; Muscle

1997
Benzodiazepine receptors influence spinal cord evoked potentials and edema following trauma to the rat spinal cord.
    Acta neurochirurgica. Supplement, 1997, Volume: 70

    Topics: Animals; Diazepam; Disease Models, Animal; Edema; Evoked Potentials; GABA-A Receptor Agonists; Male;

1997
Spinal cord evoked potentials and edema in the pathophysiology of rat spinal cord injury. Involvement of nitric oxide.
    Amino acids, 1998, Volume: 14, Issue:1-3

    Topics: Animals; Diazepam; Edema; Enzyme Inhibitors; Evoked Potentials; Fenclonine; Male; NG-Nitroarginine M

1998
Urethral striated sphincter responses to electro-bulbocavernosus stimulation.
    The Journal of urology, 1978, Volume: 119, Issue:3

    Topics: Diazepam; Electric Stimulation; Electromyography; Humans; Male; Muscle Contraction; Muscles; Penis;

1978
Diazepam effect on reflex activity in patients with complete spinal lesions and in those with other causes of spasticity.
    Archives of physical medicine and rehabilitation, 1977, Volume: 58, Issue:4

    Topics: Achilles Tendon; Action Potentials; Adult; Diazepam; Female; H-Reflex; Humans; Male; Middle Aged; Mu

1977
Effect of diazepam on muscle contraction in spasticity.
    American journal of physical medicine, 1976, Volume: 55, Issue:4

    Topics: Action Potentials; Adult; Aged; Diazepam; Female; Humans; Infusions, Parenteral; Leg; Male; Middle A

1976
The effect of diazepam on presynaptic inhibition in patients with complete and incomplete spinal cord lesions.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1975, Volume: 2, Issue:3

    Topics: Adult; Diazepam; Electric Stimulation; Female; H-Reflex; Humans; Male; Middle Aged; Multiple Scleros

1975
Spinal cord seizures: a possible cause of isolated myoclonic activity in traumatic spinal cord injury: case report.
    Paraplegia, 1991, Volume: 29, Issue:8

    Topics: Blood Pressure; Diazepam; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Post-Traumatic; H

1991
A comparison of baclofen and diazepam in the treatment of spasticity.
    Journal of the neurological sciences, 1974, Volume: 23, Issue:1

    Topics: Adult; Aminobutyrates; Body Weight; Chlorine; Diazepam; Female; Humans; Male; Middle Aged; Multiple

1974
[Studies on spasticity. I. Diazepam in the treatment of spasticity. Considerations on its management in clinical practice and neurological rehabilitation].
    Revista clinica espanola, 1969, Nov-15, Volume: 115, Issue:3

    Topics: Diazepam; Humans; Muscle Relaxants, Central; Muscle Spasticity; Paraplegia; Spinal Cord Injuries

1969
[Effect of Horizon on spastic bladder].
    Hinyokika kiyo. Acta urologica Japonica, 1970, Volume: 16, Issue:2

    Topics: Diazepam; Humans; Spinal Cord Injuries; Urinary Bladder Diseases; Urination Disorders

1970
[Conservative therapy for spasm by traumatic spinal cord injury].
    Kumamoto Igakkai zasshi. The Journal of the Kumamoto Medical Society, 1967, Feb-25, Volume: 41, Issue:2

    Topics: Adolescent; Adult; Animals; Diazepam; Exercise Therapy; Female; Humans; Male; Middle Aged; Phenols;

1967
Diazepam in the relief of muscle spasm resulting from spinal-cord lesions.
    Annals of physical medicine, 1964, Volume: Suppl

    Topics: Adolescent; Adult; Cerebrovascular Disorders; Cervical Vertebrae; Diazepam; Female; Humans; Male; Mi

1964
Use of diazepam (valium) for spasticity in spinal cord injury.
    Proceedings. Clinical Spinal Cord Injury Conference, 1964, Volume: 13

    Topics: Diazepam; Humans; Muscle Cramp; Spinal Cord Injuries

1964