diazepam has been researched along with Spasms, Infantile in 21 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we determined the efficacy of two novel neurosteroids, pregnanolone glutamate (PAG) and pregnanolone pyroglutamate (PPG), and tested these drugs in doses of 1-10 mg/kg (ip) against the TMDT syndrome and in our rodent model of infantile spasms." | 8.31 | Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms. ( Chern, CJ; Chern, CR; Chodounská, H; Kudová, E; Lauková, M; Schonwald, A; Shakarjian, MP; Velíšek, L; Velíšková, J, 2023) |
| "In this study, we determined the efficacy of two novel neurosteroids, pregnanolone glutamate (PAG) and pregnanolone pyroglutamate (PPG), and tested these drugs in doses of 1-10 mg/kg (ip) against the TMDT syndrome and in our rodent model of infantile spasms." | 4.31 | Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms. ( Chern, CJ; Chern, CR; Chodounská, H; Kudová, E; Lauková, M; Schonwald, A; Shakarjian, MP; Velíšek, L; Velíšková, J, 2023) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| "Clonazepam is a new benzodiazepine anticonvulsant recently approved by the Food and Drug Administration for the treatment of typical absence, infantile myoclonic, atypical absence, myoclonic, and akinetic seizures." | 2.35 | Clonazepam. A review of a new anticonvulsant drug. ( Browne, TR, 1976) |
| "The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG." | 1.29 | Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period. ( Blennow, G; Hellström-Westas, L; Lindroth, M; Rosén, I; Svenningsen, NW, 1995) |
| "The combination of West syndrome (WS) and Down syndrome appears not to be coincidental." | 1.29 | Early clinical and EEG features of infantile spasms in Down syndrome. ( Cieuta, C; Dulac, O; Guerrini, R; Livet, MO; Plouin, P; Silva, ML, 1996) |
| "Twelve children had previous prolonged afebrile seizures, and 18 had either prolonged or repeated febrile seizures." | 1.28 | Home use of rectal diazepam to prevent status epilepticus in children with convulsive disorders. ( Camfield, CS; Camfield, PR; Dooley, JM; Smith, E, 1989) |
| "3) Pregnancy was abnormal in 53% of cases with cerebral malformation." | 1.26 | Etiology of convulsions in neonatal and infantile period. ( Hanai, T; Kurokawa, T; Nambu, Y; Takashima, S; Yokata, K, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (66.67) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Chern, CR | 3 |
| Lauková, M | 3 |
| Schonwald, A | 3 |
| Kudová, E | 3 |
| Chodounská, H | 3 |
| Chern, CJ | 3 |
| Shakarjian, MP | 3 |
| Velíšková, J | 3 |
| Velíšek, L | 3 |
| Kobayashi, K | 1 |
| Toda, Y | 1 |
| Mimaki, T | 1 |
| Tagawa, T | 1 |
| Ono, J | 1 |
| Tanaka, J | 1 |
| Terada, H | 1 |
| Itoh, N | 1 |
| Yabuuchi, H | 1 |
| Tojo, M | 1 |
| Hellström-Westas, L | 1 |
| Blennow, G | 1 |
| Lindroth, M | 1 |
| Rosén, I | 1 |
| Svenningsen, NW | 1 |
| Hohenschild, S | 1 |
| Paust, H | 1 |
| Silva, ML | 1 |
| Cieuta, C | 1 |
| Guerrini, R | 1 |
| Plouin, P | 2 |
| Livet, MO | 1 |
| Dulac, O | 2 |
| Speciali, GG | 1 |
| Lison, MP | 1 |
| Browne, TR | 1 |
| Kurokawa, T | 1 |
| Yokata, K | 1 |
| Takashima, S | 1 |
| Nambu, Y | 1 |
| Hanai, T | 1 |
| Meldrum, BS | 1 |
| Anlezark, G | 1 |
| Balzamo, E | 1 |
| Horton, RW | 1 |
| Trimble, M | 1 |
| Shapira, Y | 1 |
| Cederbaum, SD | 1 |
| Cancilla, PA | 1 |
| Nielsen, D | 1 |
| Lippe, BM | 1 |
| Hakeem, VF | 1 |
| Wallace, SJ | 1 |
| Camfield, CS | 1 |
| Camfield, PR | 1 |
| Smith, E | 1 |
| Dooley, JM | 1 |
| Negoro, T | 1 |
| Watanabe, K | 1 |
| Jambaque, I | 1 |
| Motte, J | 1 |
| Terasaki, T | 1 |
| Yamatogi, Y | 1 |
| Ohtahara, S | 1 |
| Miyake, S | 1 |
| Iyoda, K | 1 |
| Narusawa, K | 1 |
| Livingston, S | 1 |
| Gibbs, FA | 1 |
| Anderson, EM | 1 |
| Müller, K | 1 |
| Kohlheb, O | 1 |
| Martin, D | 1 |
1 review available for diazepam and Spasms, Infantile
| Article | Year |
|---|---|
Clonazepam. A review of a new anticonvulsant drug.
Topics: Adult; Benzodiazepinones; Brain; Chemical Phenomena; Chemistry; Child; Clonazepam; Diazepam; Drug To | 1976 |
2 trials available for diazepam and Spasms, Infantile
| Article | Year |
|---|---|
[Administration of a single oral high-dose of diazepam at bedtime as therapy for intractable seizures].
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Foll | 1995 |
Treatment of hypsarrhythmia and infantile spasms with a librium analogue.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Child, Preschool; Chlordiazepoxide; Clinical Tr | 1965 |
18 other studies available for diazepam and Spasms, Infantile
| Article | Year |
|---|---|
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
[Electrophysiology of intractable childhood epilepsy].
Topics: Brain; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; | 2014 |
Antiepileptic effect and serum levels of clorazepate on children with refractory seizures.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Clorazepate Dipota | 1984 |
Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period.
Topics: Anticonvulsants; Diazepam; Drug Administration Schedule; Electroencephalography; Humans; Infant, Low | 1995 |
[Seizures and hyponatremia in a newborn infant].
Topics: Diagnosis, Differential; Diazepam; Female; Glucose Solution, Hypertonic; Humans; Hyponatremia; Infan | 1993 |
Early clinical and EEG features of infantile spasms in Down syndrome.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Comorbidity; Diazepam; Down Syndrome; Elect | 1996 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
Etiology of convulsions in neonatal and infantile period.
Topics: Age Factors; Birth Injuries; Brain; Diazepam; Electroencephalography; Female; Humans; Infant; Infant | 1976 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Familial poliodystrophy, mitochondrial myopathy, and lactate acidemia.
Topics: Adolescent; Ataxia; Cerebral Cortex; Child; Child, Preschool; Diazepam; Diffuse Cerebral Sclerosis o | 1975 |
EEG monitoring of therapy for neonatal seizures.
Topics: Anticonvulsants; Chloral Hydrate; Clonazepam; Diazepam; Drug Therapy, Combination; Electroencephalog | 1990 |
Home use of rectal diazepam to prevent status epilepticus in children with convulsive disorders.
Topics: Administration, Rectal; Adolescent; Child; Child, Preschool; Diazepam; Follow-Up Studies; Home Nursi | 1989 |
Treatment of epilepsy in infancy with special emphasis on ACTH therapy.
Topics: Administration, Rectal; Adrenocorticotropic Hormone; Diazepam; Dose-Response Relationship, Drug; Epi | 1986 |
[Benign epileptic infantile spasms].
Topics: Child, Preschool; Diazepam; Electroencephalography; Follow-Up Studies; Humans; Hydrocortisone; Infan | 1986 |
[A long-term follow-up study on a case with glycine encephalopathy].
Topics: Amino Acid Metabolism, Inborn Errors; Brain Diseases, Metabolic; Child, Preschool; Diazepam; Electro | 1988 |
Diagnosis and treatment of childhood myoclonic seizures.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain Damage, Chronic; Bromides; Child; Child, Preschool; | 1974 |
[Early results (initial effects) of the treatment with mogadan in propulsive petit mal epilepsy].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalogra | 1968 |
[Intravenous use of nitrazepam (Mogadan) in the treatment of epilepsy].
Topics: Administration, Oral; Benzazepines; Child; Child, Preschool; Diazepam; Electroencephalography; Epile | 1970 |