diazepam has been researched along with Serotonin Syndrome in 8 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To report a case of serotonin syndrome (SS) after sibutramine overdose in a child." | 7.75 | Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma. ( Barros, RF; Bucaretchi, F; da Costa, JL; de Capitani, EM; Fernandes, LC; Hyslop, S; Lanaro, R; Mello, SM, 2009) |
| "Pre-treatment with diazepam, 10 and 20mg/kg, and chlormethiazole, 50 and 100mg/kg, attenuated the development of hyperthermia." | 5.32 | Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Takano, K; Yoshino, T, 2003) |
| "To report a case of serotonin syndrome (SS) after sibutramine overdose in a child." | 3.75 | Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma. ( Barros, RF; Bucaretchi, F; da Costa, JL; de Capitani, EM; Fernandes, LC; Hyslop, S; Lanaro, R; Mello, SM, 2009) |
| "Seizures were significantly increased in rats receiving 80% and 120% of citalopram MLD versus controls (p<0." | 1.38 | Mechanisms of high-dose citalopram-induced death in a rat model. ( Baud, FJ; Beaune, S; Callebert, J; Juvin, P; Mégarbane, B; Risède, P, 2012) |
| "Pre-treatment with diazepam, 10 and 20mg/kg, and chlormethiazole, 50 and 100mg/kg, attenuated the development of hyperthermia." | 1.32 | Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Takano, K; Yoshino, T, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chioca, LR | 1 |
| Ferro, MM | 1 |
| Baretta, IP | 1 |
| Oliveira, SM | 1 |
| Silva, CR | 1 |
| Ferreira, J | 1 |
| Losso, EM | 1 |
| Andreatini, R | 1 |
| Suzuki, K | 1 |
| Zhang, P | 1 |
| Austin, E | 1 |
| Thompson, M | 1 |
| Lin, S | 1 |
| Bucaretchi, F | 1 |
| de Capitani, EM | 1 |
| Mello, SM | 1 |
| Lanaro, R | 1 |
| Barros, RF | 1 |
| Fernandes, LC | 1 |
| da Costa, JL | 1 |
| Hyslop, S | 1 |
| Dagtekin, O | 1 |
| Marcus, H | 1 |
| Müller, C | 1 |
| Böttiger, BW | 1 |
| Spöhr, F | 1 |
| Beaune, S | 1 |
| Callebert, J | 1 |
| Baud, FJ | 1 |
| Risède, P | 1 |
| Juvin, P | 1 |
| Mégarbane, B | 1 |
| Nisijima, K | 1 |
| Shioda, K | 1 |
| Yoshino, T | 1 |
| Takano, K | 1 |
| Kato, S | 1 |
| Terao, T | 1 |
| Hikichi, T | 1 |
8 other studies available for diazepam and Serotonin Syndrome
| Article | Year |
|---|---|
Anxiolytic-like effect of lavender essential oil inhalation in mice: participation of serotonergic but not GABAA/benzodiazepine neurotransmission.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Administration, Inhalation; Animals; Anti-Anxiety Agents; Be | 2013 |
[Three cases of acute serotonin syndrome due to psilocybin mushroom poisoning].
Topics: Acute Disease; Adult; Agaricales; Aged; Charcoal; Diazepam; Female; Fluid Therapy; Haloperidol; Huma | 2016 |
Challenges in a large mixed drug overdose patient.
Topics: Adult; Anticonvulsants; Body Temperature Regulation; Critical Care; Delirium; Diazepam; Drug Overdos | 2016 |
Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma.
Topics: Antidotes; Appetite Depressants; Child, Preschool; Chloral Hydrate; Chromatography, High Pressure Li | 2009 |
Lipid therapy for serotonin syndrome after intoxication with venlafaxine, lamotrigine and diazepam.
Topics: Adult; Combined Modality Therapy; Cyclohexanols; Diazepam; Emulsions; Fat Emulsions, Intravenous; Fe | 2011 |
Mechanisms of high-dose citalopram-induced death in a rat model.
Topics: Animals; Body Temperature; Citalopram; Cyproheptadine; Diazepam; Dose-Response Relationship, Drug; L | 2012 |
Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Brain; Chlormethiazole; Clorgyline; Diazepam; Diseas | 2003 |
Serotonin syndrome in a case of depression with various somatic symptoms: the difficulty in differential diagnosis.
Topics: Aged; Akathisia, Drug-Induced; Anxiety; Depressive Disorder; Diagnosis, Differential; Diazepam; Dysa | 2007 |