Page last updated: 2024-10-25

diazepam and Seizures, Febrile

diazepam has been researched along with Seizures, Febrile in 134 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Seizures, Febrile: Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)

Research Excerpts

ExcerptRelevanceReference
" access at the time of convulsions were randomised into 2 groups and treated with either intramuscular midazolam or intravenous diazepam for control of seizures."9.11Intramuscular midazolam vs intravenous diazepam for acute seizures. ( Deshmukh, CT; Shah, I, 2005)
"Compared with as-needed acetaminophen alone, diazepam with as-needed acetaminophen may reduce seizure recurrence more during the same fever episode without severe adverse events or additional costs in children with suspected SFS."8.12Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures. ( Fujita, S; Hataya, H; Kishibe, S; Miyama, S; Morikawa, EK; Morikawa, Y; Narita, K; Sammori, H; Suzuki, S; Takehira, K; Tanaka, M; Tsukamoto, J; Wang, Q; Yano, M, 2022)
" access at the time of convulsions were randomised into 2 groups and treated with either intramuscular midazolam or intravenous diazepam for control of seizures."5.11Intramuscular midazolam vs intravenous diazepam for acute seizures. ( Deshmukh, CT; Shah, I, 2005)
" Diazepam, administered only during episodes of fever, may be a safe, effective agent to prevent the recurrence of febrile seizures."5.07A controlled trial of diazepam administered during febrile illnesses to prevent recurrence of febrile seizures. ( Colton, T; Gardella, NB; Gilbert, PL; Kaye, EM; Labazzo, J; Rosman, NP; Van Bennekom, C; Winter, MR, 1993)
" Intermittent diazepam prophylaxis at times of fever may or may not reduce the recurrence rate significantly, but there is no data to suggest that it improves the long-term outcome, as compared with short-term seizure control, in terms of IQ, cognition, academic progress, motor control, and subsequent epilepsy."4.81[Febrile convulsions, Treatment and prognosis]. ( Knudsen, FU, 2001)
"Compared with as-needed acetaminophen alone, diazepam with as-needed acetaminophen may reduce seizure recurrence more during the same fever episode without severe adverse events or additional costs in children with suspected SFS."4.12Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures. ( Fujita, S; Hataya, H; Kishibe, S; Miyama, S; Morikawa, EK; Morikawa, Y; Narita, K; Sammori, H; Suzuki, S; Takehira, K; Tanaka, M; Tsukamoto, J; Wang, Q; Yano, M, 2022)
"In a prospective study 44 children, aged 6 months to 5 years, admitted to hospital with febrile convulsions or epilepsy, were treated with diazepam in solution administered rectally during 59 generalised attacks."3.66Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children. ( Knudsen, FU, 1979)
"Both melatonin and diazepam were given only during the febrile illness, started at the onset of the fever for 48 to 72 hours."2.90Comparison Between Efficacy of Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures: A Randomized Clinical Trial. ( Al-Shahawy, AK; Barghout, MS; Darwish, AH; El Amrousy, DM, 2019)
"We studied 203 children with febrile seizures from December 2004 through March 2006."2.74Efficacy of a diazepam suppository at preventing febrile seizure recurrence during a single febrile illness. ( Hirabayashi, Y; Kando, N; Kawabe, S; Kondo, T; Magota, M; Natsume, J; Negoro, T; Okumura, A; Watanabe, K; Yamaguchi, H, 2009)
"Oral diazepam or placebo was given for fevers to 406 children with at least one previous febrile seizure."2.70Preventing febrile seizures in children with oral diazepam: can a controlled trial truly be "double-blind?". ( Douglass, LM; Paolini, JL; Rosman, NP, 2001)
"Acetaminophen had no effect on the recurrence rate."2.68Effect of acetaminophen and of low intermittent doses of diazepam on prevention of recurrences of febrile seizures. ( Kurttila, R; Rantala, H; Uhari, M; Vainionpää, L, 1995)
"A cohort of 289 children with febrile convulsions who had been randomised in early childhood to either intermittent prophylaxis (diazepam at fever) or no prophylaxis (diazepam at seizures) was followed up 12 years later."2.68Long term outcome of prophylaxis for febrile convulsions. ( Andersen, R; Andresen, J; Knudsen, FU; Paerregaard, A, 1996)
"Children with simple and complex febrile convulsions had the same benign outcome."2.68[Long-term prognosis in febrile convulsions with and without prophylaxis]. ( Andersen, R; Andresen, J; Knudsen, FU; Paerregaard, A, 1997)
"The number of complex recurrences, however, were significantly higher in the valproic acid group than in the diazepam group."2.67Intermittent prophylaxis in febrile convulsions: diazepam or valproic acid? ( Ankerhus, J; Brems, M; Daugbjerg, P; Knudsen, FU; Mai, J, 1990)
"The 18 month recurrence rate was 80 to 100% if three to five risk factors were present, 50% if two factors were identified, 25% where one factor was found, and 12% if there were no predictors."2.66Recurrence risk after first febrile seizure and effect of short term diazepam prophylaxis. ( Knudsen, FU, 1985)
"Rate of recurrent febrile seizures was 16% in control group, and 5."2.66[Preventing the recurrence of febrile seizures: intermittent prevention with rectal diazepam compared with continuous treatment with sodium valproate]. ( Cabrero, A; Fernández, RM; Fidalgo, I; Mosquera, C; Rodríguez, J, 1987)
"Valproic acid and diazepam were found to be equally effective in reducing the risk of recurrence of febrile convulsions."2.66Prophylactic treatment with valproic acid or diazepam in children with febrile convulsions. ( Hvorslev, V; Lee, K; Taudorf, K, 1986)
"New convulsions were of similar duration and severity in both groups."2.64Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. ( Knudsen, FU; Vestermark, S, 1978)
"Febrile seizures are the most common type of childhood seizures, affecting 2% to 5% of children."2.49Complex febrile seizures: a practical guide to evaluation and treatment. ( Patel, AD; Vidaurre, J, 2013)
"For most febrile seizures, whether simple or complex, education and counseling are the primary modes of treatment."2.42Febrile seizures. ( O'Dell, C; Shinnar, S, 2004)
"Recurrences are common."2.42[Febrile seizures--an update]. ( Püst, B, 2004)
"However, there is no evidence that treatment of simple febrile seizures can prevent the rare cases of later epilepsy, and many children with complex febrile seizures have a benign long-term outcome, even without treatment."2.41Febrile seizures: treatment and prognosis. ( Knudsen, FU, 2000)
"Febrile seizures are the most frequent neurologic disorders during childhood."2.40[Febrile convulsions: assessment of current status]. ( Blumberg, A; Donati, F; Gubser, M, 1999)
"The risk of recurrences was significantly lower in children receiving continuous phenobarbital therapy than placebo (odds ratio 0."2.40A meta-analytic review of the preventive treatment of recurrences of febrile seizures. ( Rantala, H; Tarkka, R; Uhari, M, 1997)
"Febrile seizures are common in children."2.37The child with febrile seizures. ( Wright, SW, 1987)
"Seizure recurrence within 24 h was observed in 16% of participants and was independently associated with preceding use of diazepam and family history of FS."1.72Risk factors for acute encephalitis and early seizure recurrence in complex febrile seizures. ( Kajiwara, K; Koga, H, 2022)
"None presented afebrile seizures."1.72Non-convulsive febrile status epilepticus mimicking a postictal state after a febrile seizure: an ictal electroclinical and evolutive study. ( Bernardina, BD; Cantalupo, G; Darra, F; Fiorini, E; Fontana, E; Lo Barco, T; Meneghello, L; Proietti, J, 2022)
"On the whole, the clinical features of febrile seizures during viral gastroenteritis may closely resemble those of "convulsions with mild gastroenteritis" (CwG) than those of febrile seizures in general with respect to the frequency of clustered seizures and the antiepileptic drug responses and may have a pathogenic mechanism distinct from those of febrile seizures due to other causes."1.42Clinical characteristics of seizures associated with viral gastroenteritis in children. ( Baba, Y; Etani, Y; Hosoi, G; Kimura, S; Kusumoto, Y; Maruyama, T; Nagai, T; Noma, H; Tajiri, H; Takano, T; Ueda, H, 2015)
"Seven (21."1.40Intermittent prophylaxis of recurrent febrile seizures with clobazam versus diazepam. ( Ahmed, AU; Banu, LA; Begum, SA; Haque, MA; Hoque, MR; Karim, MM; Momen, A; Parveen, F; Quddush, MR; Saha, SK; Sattar, S, 2014)
"Prolonged febrile seizures (PFS) lasting ≥15 min have been associated with increased risk for epilepsy in later life."1.39Prolonged febrile seizures, clinical characteristics, and acute management. ( Barzilay, M; Bassan, H; Gross-Tsur, V; Matoth, I; Shinnar, S; Shorer, Z, 2013)
"Malaria was the main etiology in 67."1.36[Clinical, etiological, and therapeutic aspects of febrile convulsions. A review of 325 cases in Yaoundé]. ( Chiabi, A; Fru, F; Kuate Tegueu, C; Mah, E; Mbonda, E; Ngo Kana, CA; Nguefack, S; Tchokoteu, PF, 2010)
"Children with a diagnosis of febrile convulsions or relevant differential diagnoses were eligible for inclusion."1.35[Prehospital management of febrile convulsions by the Mobile Emergency Care Unit in the Capital Region of Denmark]. ( Lindekaer, AL; Nielsen, SL; Pedersen, UG, 2008)
"For children with prolonged or multiple febrile seizures, diazepam rectal gel (Diastat) is a safe and effective treatment."1.32Febrile seizures: an overview. ( Chadwick, DJ, 2003)
"The two main phenotypes were childhood absence epilepsy (CAE) and febrile seizures (FS)."1.31Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. ( Berkovic, SF; Bowser, DN; Harkin, LA; Marini, C; Mulley, JC; Panchal, RG; Petrou, S; Scheffer, IE; Sutherland, GR; Wallace, RH; Williams, DA, 2001)
"Forty six children admitted with febrile seizures were orally administered with 0."1.31Serum diazepam levels after oral administration in children. ( Chiemchanya, S; Kanjanarungsichai, A; Kaojarern, S; Pichaipat, V; Visudhiphan, P; Visudtibhan, A, 2002)
"The families of 42 children with febrile seizures were recruited after pediatric or neuropediatric consultation."1.31Treatment of febrile seizures: the influence of treatment efficacy and side-effect profile on value to parents. ( Camfield, CS; Camfield, PR; Dooley, JM; Gordon, KE; MacSween, J, 2001)
" There was no statistical difference as to the mean dosage of diazepam or chloral hydrate between the patients with and without recurrence."1.30[Efficacy of rectal diazepam suppository in the prophylaxis of febrile seizures: comparison with rectal chloral hydrate suppository]. ( Kuremoto, K; Oyama, S; Shimazaki, S, 1997)
"Simple febrile seizures that occur in children ages 6 months to 5 years are common events with few adverse outcomes."1.30Technical report: treatment of the child with simple febrile seizures. ( Baumann, RJ, 1999)
"The treatment of febrile convulsions is intra-rectal diazepam (0."1.30[Febrile convulsions and other occasional convulsions in children]. ( Cuisset, JM; Cuvellier, JC; de Sèze, C; Vallée, L, 1999)
"Preventive treatment of recurrence is mainly indicated in case of complex seizures using either prolonged daily monotherapy, preferentially sodium valproate, or intermittent administration of diazepam during febrile illnesses."1.29[Treatment of febrile convulsions in infants]. ( Bourrillon, A, 1995)
"They have had simple or complex febrile seizures."1.29[Intermittent prophylaxis in febrile seizures with oral diazepam: study of 82 cases]. ( Costa, M; Guerreiro, MM; Silva, AE; Silva, EA, 1996)
"They had either simple or complex febrile seizures."1.28[Intermittent prophylaxis in febrile convulsions with oral diazepam]. ( Bellomo, MA; Costa, M; Guerreiro, MM; Sabino, SH; Scotoni, AE; Silva, EA, 1992)
"Twelve children had previous prolonged afebrile seizures, and 18 had either prolonged or repeated febrile seizures."1.28Home use of rectal diazepam to prevent status epilepticus in children with convulsive disorders. ( Camfield, CS; Camfield, PR; Dooley, JM; Smith, E, 1989)
"Diazepam was found to be as effective as oral phenobarbital in the prevention of new febrile seizures."1.27[Continuous oral phenobarbital or intermittent rectal diazepam for the prevention of febrile convulsions]. ( Campos-Castelló, J; Careaga Maldonado, J; Oliete García, F, 1984)
" Most of the observed plasma diazepam levels were found to be within +/- one standard deviation of the values calculated from the pharmacokinetic parameters in six other infants with single rectal dosing."1.27Pharmacokinetics of rectal diazepam in the prevention of recurrent febrile convulsions. ( Minagawa, K; Miura, H; Mizuno, S; Shirai, H, 1986)
"Diazepam clisma was administered correctly in 70 episodes (64."1.26Home treatment of seizures as a strategy for the long-term management of febrile convulsions in children. ( Basso, T; Bortolan, G; Gardini, A; Guidobaldi, G; Lorusso, G; Marinoni, S; Merli, A; Messi, G; Muner, M; Mussi, G; Patamia, F; Rabusin, P; Sacher, B; Ulliana, A; Ventura, A, 1982)
"A Consensus Development Conference on Febrile Seizures was held at the National Institutes of Health in USA in May 1980."1.26["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis]. ( Helwig, H; Staudt, F, 1982)
" Acetaminophen and diazepam seemed to be well absorbed from the rectal suppositories, the maximal plasma concentration of diazepam after a rectal dose of 0."1.26Antipyretic effect and plasma concentrations of rectal acetaminophen and diazepam in children. ( Kangas, L; Keinänen-Kiukaanniemi, S; Luoma, P; Saukkonen, AL; Similä, S, 1979)
"Eighty-seven per cent of convulsions lasted for less than 15 minutes and in only two instances did they last longer than 30 minutes."1.26Febrile convulsions--what do parents do? ( Metcalfe, DH; Rutter, N, 1978)

Research

Studies (134)

TimeframeStudies, this research(%)All Research%
pre-199052 (38.81)18.7374
1990's36 (26.87)18.2507
2000's29 (21.64)29.6817
2010's13 (9.70)24.3611
2020's4 (2.99)2.80

Authors

AuthorsStudies
Proietti, J1
Fiorini, E1
Meneghello, L1
Cantalupo, G1
Fontana, E1
Lo Barco, T1
Bernardina, BD1
Darra, F1
Tanaka, M1
Wang, Q1
Morikawa, Y1
Tsukamoto, J1
Sammori, H1
Takehira, K1
Yano, M1
Miyama, S1
Fujita, S1
Narita, K1
Kishibe, S1
Morikawa, EK1
Suzuki, S1
Hataya, H1
Kajiwara, K1
Koga, H2
Barghout, MS1
Al-Shahawy, AK1
El Amrousy, DM1
Darwish, AH1
Inoue, M1
Adachi, S1
Kawakami, I1
Bassan, H1
Barzilay, M1
Shinnar, S2
Shorer, Z1
Matoth, I1
Gross-Tsur, V1
Patel, AD1
Vidaurre, J1
Ruusuvuori, E1
Huebner, AK1
Kirilkin, I1
Yukin, AY1
Blaesse, P1
Helmy, M1
Kang, HJ1
El Muayed, M1
Hennings, JC1
Voipio, J1
Šestan, N1
Hübner, CA1
Kaila, K1
Sattar, S1
Saha, SK1
Parveen, F1
Banu, LA1
Momen, A1
Ahmed, AU1
Quddush, MR1
Karim, MM1
Begum, SA1
Haque, MA1
Hoque, MR1
Ueda, H1
Tajiri, H1
Kimura, S1
Etani, Y1
Hosoi, G1
Maruyama, T1
Noma, H1
Kusumoto, Y1
Takano, T1
Baba, Y1
Nagai, T1
Hirabayashi, Y2
Okumura, A3
Kondo, T1
Magota, M1
Kawabe, S1
Kando, N1
Yamaguchi, H1
Natsume, J2
Negoro, T2
Watanabe, K2
Pedersen, UG1
Lindekaer, AL1
Nielsen, SL1
O'Dell, C1
Nguefack, S1
Ngo Kana, CA1
Mah, E1
Kuate Tegueu, C1
Chiabi, A1
Fru, F1
Tchokoteu, PF1
Mbonda, E1
Sert, A1
Yazar, A1
Odabas, D1
Auvin, S1
Desnous, B1
Bellavoine, V1
Gressens, P1
Boespflug-Tanguy, O1
Khosroshahi, N1
Faramarzi, F1
Salamati, P1
Haghighi, SM1
Kamrani, K1
Saz, EU1
Karapinar, B1
Ozcetin, M1
Polat, M1
Tosun, A1
Serdaroglu, G1
Gokben, S1
Tekgul, H1
Wilhelm, EA1
Souza, AC1
Gai, BM1
Chagas, PM1
Roehrs, JA1
Nogueira, CW1
Visudtibhan, A1
Chiemchanya, S2
Visudhiphan, P2
Kanjanarungsichai, A1
Kaojarern, S1
Pichaipat, V1
Chadwick, DJ1
Riedl, B1
Masuko, AH1
Castro, AA1
Santos, GR1
Atallah, AN1
do Prado, LB1
de Carvalho, LB1
do Prado, GF1
Verrotti, A1
Latini, G1
di Corcia, G1
Giannuzzi, R1
Salladini, C1
Trotta, D1
Chiarelli, F1
Ishiguro, Y1
Sofue, A1
Suzuki, Y1
Maruyama, K1
Kubota, T1
Waruiru, C1
Appleton, R1
Püst, B1
Kang, JQ1
Kang, J1
Macdonald, RL1
Li, XJ1
Cai, FC1
Jiang, L1
Shah, I1
Deshmukh, CT1
Millar, JS1
Pavlidou, E2
Tzitiridou, M1
Panteliadis, C1
Panteliadis, CP1
Mallet, E1
de Menibus, CH1
Pellerin, MA1
Menard, JF1
Escorihuela, R1
Sandiumenge, J1
Oliete García, F1
Campos-Castelló, J1
Careaga Maldonado, J1
Benchet, ML1
Tardieu, M1
Landrieu, P1
Taburet, AM1
Singlas, E1
Debauchez, C1
Addy, DP1
Valman, HB3
Staudt, F1
Helwig, H1
Deonna, T2
Ventura, A1
Basso, T1
Bortolan, G1
Gardini, A1
Guidobaldi, G1
Lorusso, G1
Marinoni, S1
Merli, A1
Messi, G1
Mussi, G1
Muner, M1
Patamia, F1
Rabusin, P1
Sacher, B1
Ulliana, A1
le Coultre, R1
Dianese, G3
Voorhoeve, HM1
Bourrillon, A1
Camfield, PR4
Camfield, CS4
Gordon, K1
Dooley, JM3
Uhari, M3
Rantala, H3
Vainionpää, L1
Kurttila, R1
Khositseth, A1
Camfield, P1
Camfield, C1
Fischbein, CA1
Berg, IJ1
Leiner, S1
Berg, AT1
Shetty, T1
Korinthenberg, R1
Rossi, LN2
Chiodi, A1
Bossi, A2
Cortinovis, I2
Alberti, S1
Rosman, NP4
Colton, T1
Labazzo, J1
Gilbert, PL1
Gardella, NB1
Kaye, EM1
Van Bennekom, C1
Winter, MR1
Knudsen, FU13
Paerregaard, A2
Andersen, R2
Andresen, J2
Boomsma, L1
van der Laan, JR1
Costa, M2
Silva, EA2
Silva, AE1
Guerreiro, MM2
Shimazaki, S1
Kuremoto, K1
Oyama, S1
Tarkka, R2
Pokka, T1
Doose, H1
Vining, EP1
Watanabe, T1
Baumann, RJ1
Gubser, M1
Blumberg, A1
Donati, F1
Lahat, E1
Goldman, M1
Barr, J1
Bistritzer, T1
Berkovitch, M1
Vallée, L1
Cuisset, JM1
Cuvellier, JC1
de Sèze, C1
Ling, SG1
Wassner, E1
Morris, B1
Fernando, L1
Rao, M1
Whitehouse, WP1
Douglass, LM1
Paolini, JL1
Wallace, RH1
Marini, C1
Petrou, S1
Harkin, LA1
Bowser, DN1
Panchal, RG1
Williams, DA1
Sutherland, GR1
Mulley, JC1
Scheffer, IE1
Berkovic, SF1
Osawa, M1
Kaneko, K1
Hayashi, K1
Depiero, AD1
Teach, SJ1
Gordon, KE1
MacSween, J1
Autret-Leca, E1
Ployet, JL1
Jonville-Bera, AP1
Awaya, Y1
Mimaki, T1
Kamiya, H1
Ooya, T1
Terada, H1
Okazaki, T1
Otani, K1
Vestermark, S2
Borgheresi, S1
Luti, E1
Buti Cossi, D1
Mecherini, L1
Bardini, MR1
Burgio, E1
Ciampi, C1
Benocci, M1
Massai, S1
Lini, M1
Grifi, G1
Valenza, T1
Dianese, GF1
Faccioli, G1
Keinänen-Kiukaanniemi, S1
Similä, S1
Luoma, P1
Kangas, L1
Saukkonen, AL1
Kallio, AK1
Hoppu, K1
Rutter, N1
Metcalfe, DH1
Ounsted, C1
Ferngren, H1
Dolanský, J1
Bellomo, MA1
Sabino, SH1
Scotoni, AE1
Mattigk, G1
Maiti, B1
DeMuri, G1
Langkamp, DL1
Miceli Sopo, S1
Pesaresi, MA1
Celestini, E1
Stabile, A1
Newton, RW2
Autret, E1
Billard, C1
Bertrand, P1
Motte, J1
Pouplard, F1
Jonville, AP1
Daugbjerg, P1
Brems, M1
Mai, J1
Ankerhus, J1
McKinlay, I2
Newton, R1
Lausecker, M1
Novak, M1
Stögmann, W1
Rossi, G1
Brunelli, G1
Smith, E1
Lee, K1
Taudorf, K1
Hvorslev, V1
Mosquera, C1
Rodríguez, J1
Cabrero, A1
Fidalgo, I1
Fernández, RM1
Wright, SW1
Riikonen, R1
Manson, JI1
Minagawa, K4
Miura, H4
Mizuno, S4
Shirai, H4
Hohjo, M1
Herranz Fernández, JL1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Efficacy of A Single Dose Clonazepam Compared With the Intermittent Diazepam to Prevent Recurrent Febrile Seizures in Queen Sirikit National Institute of Child Health[NCT04364321]74 participants (Anticipated)Interventional2020-05-13Recruiting
Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612]Phase 2358 participants (Actual)Interventional2006-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Seizure After Study Medication Administration

Length of seizure. (NCT00326612)
Timeframe: 24 hours

InterventionMinutes (Median)
Intranasal Midazolam3.0
Rectal Diazepam4.3

Number of Patients Needed to be Seen or Treated in the Emergency Department for Their Seizure and Use of Study Medication.

(NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam21
Rectal Diazepam17

Number of Patients That Were Admitted to the Hospital After Their Seizure and Use of Study Medication.

(NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam4
Rectal Diazepam3

Number of Patients Who Had a Repeat Seizure Within 12 Hours After Their Seizure Who Used Study Medication

(NCT00326612)
Timeframe: 12 hours

Interventionparticipants (Number)
Intranasal Midazolam1
Rectal Diazepam1

Number of Patients Who Needed Additional Medication to Treat the Seizure in the Emergency Department Within 24 Hours

(NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam5
Rectal Diazepam5

Respiratory Depression Requiring Intubation

Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam1
Rectal Diazepam0

Respiratory Depression Requiring Oxygen at Discharge From the Emergency Department.

Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam3
Rectal Diazepam1

Reviews

19 reviews available for diazepam and Seizures, Febrile

ArticleYear
Complex febrile seizures: a practical guide to evaluation and treatment.
    Journal of child neurology, 2013, Volume: 28, Issue:6

    Topics: Algorithms; Anticonvulsants; Critical Pathways; Cross-Sectional Studies; Diazepam; Emergency Service

2013
Febrile seizures.
    Pediatric annals, 2004, Volume: 33, Issue:6

    Topics: Age Factors; Anticonvulsants; Child, Preschool; Counseling; Diazepam; Drug Administration Schedule;

2004
Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis.
    Arquivos de neuro-psiquiatria, 2003, Volume: 61, Issue:4

    Topics: Anticonvulsants; Diazepam; Follow-Up Studies; Humans; Odds Ratio; Phenobarbital; Placebos; Randomize

2003
Febrile seizures: an update.
    Archives of disease in childhood, 2004, Volume: 89, Issue:8

    Topics: Anticonvulsants; Central Nervous System Diseases; Child; Diazepam; Epilepsy, Temporal Lobe; Humans;

2004
[Febrile seizures--an update].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 2004, Volume: 23, Issue:8

    Topics: Administration, Oral; Administration, Rectal; Age Factors; Analgesics, Non-Narcotic; Anticonvulsants

2004
[Use of phenobarbital in febrile convulsive crisis].
    Anales espanoles de pediatria, 1983, Volume: 18, Issue:2

    Topics: Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Nervous System Diseases; Phenobarbital; Recurr

1983
Management and treatment of febrile seizures.
    Current problems in pediatrics, 1997, Volume: 27, Issue:1

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Blood Chemical Analysis; Child, Preschool; Diagnosis, Dif

1997
A meta-analytic review of the preventive treatment of recurrences of febrile seizures.
    The Journal of pediatrics, 1997, Volume: 131, Issue:6

    Topics: Anticonvulsants; Chi-Square Distribution; Child; Diazepam; Drug Administration Schedule; Fever; Huma

1997
[Febrile convulsions: assessment of current status].
    Schweizerische medizinische Wochenschrift, 1999, May-01, Volume: 129, Issue:17

    Topics: Administration, Rectal; Anticonvulsants; Child; Diazepam; Humans; Prognosis; Seizures, Febrile

1999
Febrile seizures: treatment and prognosis.
    Epilepsia, 2000, Volume: 41, Issue:1

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Cognition; Diazepam; Epilepsy; Humans; Intelligence; Prog

2000
[Febrile convulsions, Treatment and prognosis].
    Ugeskrift for laeger, 2001, Feb-19, Volume: 163, Issue:8

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe

2001
[The current status and problems of the unauthorized drugs in pediatric neurology].
    No to hattatsu = Brain and development, 2001, Volume: 33, Issue:3

    Topics: Autoimmune Diseases; Child; Diazepam; Humans; Immunoglobulins, Intravenous; Insurance Coverage; Japa

2001
[Prevention of recurrences and of epilepsy in febrile convulsions. Protocol of the Pediatric Clinic of the Florence and preliminary results].
    Minerva pediatrica, 1979, Nov-30, Volume: 31, Issue:22

    Topics: Age Factors; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence;

1979
[Current therapy of febrile convulsions].
    Kinderarztliche Praxis, 1992, Volume: 60, Issue:4-5

    Topics: Adolescent; Adult; Child; Child, Preschool; Clonazepam; Diazepam; Humans; Infant; Seizures, Febrile

1992
Febrile convulsion.
    Journal of the Indian Medical Association, 1991, Volume: 89, Issue:8

    Topics: Bacterial Infections; Diagnosis, Differential; Diazepam; Humans; Prognosis; Seizures, Febrile

1991
The first year of life. Convulsions in the older infant.
    BMJ (Clinical research ed.), 1989, Nov-25, Volume: 299, Issue:6711

    Topics: Cold Temperature; Diazepam; Female; Humans; Infant; Male; Paraldehyde; Prognosis; Seizures, Febrile

1989
Subsequent management of children with febrile convulsions.
    Developmental medicine and child neurology, 1988, Volume: 30, Issue:3

    Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Seizures, Febrile

1988
Febrile seizures.
    Emergency medicine clinics of North America, 1987, Volume: 5, Issue:4

    Topics: Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Female

1987
The child with febrile seizures.
    American family physician, 1987, Volume: 36, Issue:5

    Topics: Child, Preschool; Diagnosis, Differential; Diazepam; Fever; Humans; Infant; Phenobarbital; Prognosis

1987

Trials

26 trials available for diazepam and Seizures, Febrile

ArticleYear
Comparison Between Efficacy of Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures: A Randomized Clinical Trial.
    Pediatric neurology, 2019, Volume: 101

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Melatonin; Prospective St

2019
Efficacy of a diazepam suppository at preventing febrile seizure recurrence during a single febrile illness.
    Brain & development, 2009, Volume: 31, Issue:6

    Topics: Age Factors; Anticonvulsants; Child, Preschool; Diagnosis, Differential; Diagnostic Errors; Diazepam

2009
Diazepam versus clobazam for intermittent prophylaxis of febrile seizures.
    Indian journal of pediatrics, 2011, Volume: 78, Issue:1

    Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Diazepam; Female; Humans; Infant; Male

2011
Intermittent oral diazepam prophylaxis in febrile convulsions: its effectiveness for febrile seizure recurrence.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2004, Volume: 8, Issue:3

    Topics: Administration, Oral; Administration, Rectal; Anticonvulsants; Child, Preschool; Diazepam; Female; F

2004
Intramuscular midazolam vs intravenous diazepam for acute seizures.
    Indian journal of pediatrics, 2005, Volume: 72, Issue:8

    Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Humans; Infant; Injections, Intramuscular; Injec

2005
Effectiveness of intermittent diazepam prophylaxis in febrile seizures: long-term prospective controlled study.
    Journal of child neurology, 2006, Volume: 21, Issue:12

    Topics: Age Factors; Age of Onset; Anticonvulsants; Brain; Child, Preschool; Diazepam; Dose-Response Relatio

2006
Effect of acetaminophen and of low intermittent doses of diazepam on prevention of recurrences of febrile seizures.
    The Journal of pediatrics, 1995, Volume: 126, Issue:6

    Topics: Acetaminophen; Child, Preschool; Diazepam; Double-Blind Method; Drug Administration Schedule; Drug T

1995
A controlled trial of diazepam administered during febrile illnesses to prevent recurrence of febrile seizures.
    The New England journal of medicine, 1993, Jul-08, Volume: 329, Issue:2

    Topics: Administration, Oral; Child, Preschool; Diazepam; Double-Blind Method; Drug Administration Schedule;

1993
Long term outcome of prophylaxis for febrile convulsions.
    Archives of disease in childhood, 1996, Volume: 74, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child Development; Cognition; Diazepam; Epilepsy; Follow-Up Stud

1996
[Long-term prognosis in febrile convulsions with and without prophylaxis].
    Ugeskrift for laeger, 1997, Jun-02, Volume: 159, Issue:23

    Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Follow-Up Studies; Humans; Infant; Motor Activit

1997
Risk of recurrence and outcome after the first febrile seizure.
    Pediatric neurology, 1998, Volume: 18, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Drug Therapy,

1998
Comparison of intranasal midazolam with intravenous diazepam for treating febrile seizures in children: prospective randomised study.
    BMJ (Clinical research ed.), 2000, Jul-08, Volume: 321, Issue:7253

    Topics: Administration, Intranasal; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infa

2000
Preventing febrile seizures in children with oral diazepam: can a controlled trial truly be "double-blind?".
    The Journal of pediatrics, 2001, Volume: 138, Issue:4

    Topics: Administration, Oral; Anticonvulsants; Child, Preschool; Diazepam; Double-Blind Method; Female; Huma

2001
[Prevention of febrile convulsions with diazepam or phenemal. A prospective controlled study].
    Ugeskrift for laeger, 1978, May-01, Volume: 140, Issue:18

    Topics: Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Humans; Infant; Phenobarbital; Prospect

1978
Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study.
    Archives of disease in childhood, 1978, Volume: 53, Issue:8

    Topics: Child, Preschool; Clinical Trials as Topic; Diazepam; Female; Humans; Infant; Male; Phenobarbital; P

1978
Plasma-diazepam in infants after rectal administration in solution and by suppository.
    Acta paediatrica Scandinavica, 1977, Volume: 66, Issue:5

    Topics: Child, Preschool; Diazepam; Humans; Infant; Phenobarbital; Rectum; Seizures, Febrile; Solutions; Sup

1977
Intermittent diazepam prophylaxis in febrile convulsions. Pros and cons.
    Acta neurologica Scandinavica. Supplementum, 1991, Volume: 135

    Topics: Behavior; Child, Preschool; Diazepam; Drug Administration Schedule; Epilepsy; Humans; Infant; Patien

1991
Short-term prophylaxis of febrile convulsions.
    Acta paediatrica Scandinavica, 1991, Volume: 80, Issue:2

    Topics: Child; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Phenobarbital; Prospective Studies;

1991
Double-blind, randomized trial of diazepam versus placebo for prevention of recurrence of febrile seizures.
    The Journal of pediatrics, 1990, Volume: 117, Issue:3

    Topics: Administration, Oral; Child, Preschool; Diazepam; Double-Blind Method; Drug Evaluation; Female; Huma

1990
Intermittent prophylaxis in febrile convulsions: diazepam or valproic acid?
    Acta neurologica Scandinavica, 1990, Volume: 82, Issue:1

    Topics: Diazepam; Female; Humans; Infant; Male; Prospective Studies; Randomized Controlled Trials as Topic;

1990
Intention to treat febrile convulsions with rectal diazepam, valproate or phenobarbitone.
    Developmental medicine and child neurology, 1989, Volume: 31, Issue:5

    Topics: Administration, Rectal; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Phenobarbit

1989
Prophylactic treatment with valproic acid or diazepam in children with febrile convulsions.
    Acta paediatrica Scandinavica, 1986, Volume: 75, Issue:4

    Topics: Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Female; Humans; Infant; Male; Recurrenc

1986
[Preventing the recurrence of febrile seizures: intermittent prevention with rectal diazepam compared with continuous treatment with sodium valproate].
    Anales espanoles de pediatria, 1987, Volume: 27, Issue:5

    Topics: Administration, Rectal; Adolescent; Adult; Child; Diazepam; Drug Administration Schedule; Female; Hu

1987
Frequent febrile episodes and recurrent febrile convulsions.
    Acta neurologica Scandinavica, 1988, Volume: 78, Issue:5

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Prospective Studies; Random Allocation;

1988
Recurrence risk after first febrile seizure and effect of short term diazepam prophylaxis.
    Archives of disease in childhood, 1985, Volume: 60, Issue:11

    Topics: Age Factors; Clinical Trials as Topic; Diazepam; Female; Humans; Infant; Male; Prospective Studies;

1985
Effective short-term diazepam prophylaxis in febrile convulsions.
    The Journal of pediatrics, 1985, Volume: 106, Issue:3

    Topics: Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Male; Patient Compliance; Random Alloc

1985

Other Studies

89 other studies available for diazepam and Seizures, Febrile

ArticleYear
Non-convulsive febrile status epilepticus mimicking a postictal state after a febrile seizure: an ictal electroclinical and evolutive study.
    Epileptic disorders : international epilepsy journal with videotape, 2022, Apr-01, Volume: 24, Issue:2

    Topics: Child; Cyanosis; Diazepam; Electroencephalography; Fever; Humans; Infant; Seizures, Febrile; Status

2022
Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures.
    Epilepsia, 2022, Volume: 63, Issue:7

    Topics: Acetaminophen; Child; Diazepam; Fever; Humans; Infant; Prospective Studies; Recurrence; Seizures, Fe

2022
Risk factors for acute encephalitis and early seizure recurrence in complex febrile seizures.
    European journal of pediatrics, 2022, Volume: 181, Issue:8

    Topics: Child; Child, Preschool; Diazepam; Encephalitis; Humans; Infant; Recurrence; Retrospective Studies;

2022
Change in the strategy for prophylactic diazepam use for febrile seizures and the impact on seizure recurrence within 24 h.
    Seizure, 2020, Volume: 75

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Drug Administration Routes; Female; Humans; Infant; Jap

2020
Prolonged febrile seizures, clinical characteristics, and acute management.
    Epilepsia, 2013, Volume: 54, Issue:6

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Emergency Medical Services; Emergency Service, Hospital

2013
Neuronal carbonic anhydrase VII provides GABAergic excitatory drive to exacerbate febrile seizures.
    The EMBO journal, 2013, Aug-14, Volume: 32, Issue:16

    Topics: Age Factors; Analysis of Variance; Animals; Blotting, Northern; Blotting, Western; Carbonic Anhydras

2013
Intermittent prophylaxis of recurrent febrile seizures with clobazam versus diazepam.
    Mymensingh medical journal : MMJ, 2014, Volume: 23, Issue:4

    Topics: Age Factors; Anticonvulsants; Ataxia; Bangladesh; Benzodiazepines; Chi-Square Distribution; Child, P

2014
Clinical characteristics of seizures associated with viral gastroenteritis in children.
    Epilepsy research, 2015, Volume: 109

    Topics: Anticonvulsants; Caliciviridae Infections; Carbamazepine; Child, Preschool; Diazepam; Female; Gastro

2015
[Prehospital management of febrile convulsions by the Mobile Emergency Care Unit in the Capital Region of Denmark].
    Ugeskrift for laeger, 2008, Nov-24, Volume: 170, Issue:48

    Topics: Ambulances; Anticonvulsants; Child; Child, Preschool; Consumer Behavior; Denmark; Diagnosis, Differe

2008
[Clinical, etiological, and therapeutic aspects of febrile convulsions. A review of 325 cases in Yaoundé].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2010, Volume: 17, Issue:5

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Cameroon; Child, Preschool; Cross-Sectional Studies; Diaz

2010
Efficacy of a diazepam at preventing febrile seizure recurrence after febrile illness.
    Brain & development, 2010, Volume: 32, Issue:10

    Topics: Anticonvulsants; Child; Diazepam; Fever; Humans; Secondary Prevention; Seizures, Febrile; Suppositor

2010
[Febrile seizure: underlying mechanisms, consequences and management].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2010, Volume: 17, Issue:6

    Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Diazepam; Female; Follow-Up Studies; Hum

2010
Reply comments to 'Efficacy of a diazepam at preventing febrile seizure recurrence after febrile illness'.
    Brain & development, 2011, Volume: 33, Issue:1

    Topics: Anticonvulsants; Clinical Trials as Topic; Diazepam; Fever; Secondary Prevention; Seizures, Febrile;

2011
Convulsive status epilepticus in children: etiology, treatment protocol and outcome.
    Seizure, 2011, Volume: 20, Issue:2

    Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Encephalitis; Female; Humans; Infant; Male; Meni

2011
Hyperthermic seizures enhance responsiveness to pentylenetetrazole and induce cognitive dysfunction: protective effect of 3-alkynyl selenophene.
    Life sciences, 2012, May-15, Volume: 90, Issue:17-18

    Topics: Animals; Anticonvulsants; Cognition Disorders; Convulsants; Diazepam; Hyperthermia, Induced; Male; M

2012
Serum diazepam levels after oral administration in children.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2002, Volume: 85 Suppl 4

    Topics: Administration, Oral; Anticonvulsants; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Sei

2002
Febrile seizures: an overview.
    Minnesota medicine, 2003, Volume: 86, Issue:3

    Topics: Administration, Rectal; Child; Child, Preschool; Diazepam; Humans; Infant; Risk Factors; Secondary P

2003
[A common emergency in childhood. Febrile convulsions -- what to do?].
    MMW Fortschritte der Medizin, 2003, Feb-27, Volume: 145, Issue:9

    Topics: Acetaminophen; Administration, Rectal; Age Factors; Analgesics, Non-Narcotic; Anticonvulsants; Clona

2003
Treatment and outcome in patients with febrile convulsion associated with epileptiform discharges on electroencephalography.
    Brain & development, 2004, Volume: 26, Issue:4

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Drug Administration Schedule; Electroencephalography; E

2004
The GABAA receptor gamma2 subunit R43Q mutation linked to childhood absence epilepsy and febrile seizures causes retention of alpha1beta2gamma2S receptors in the endoplasmic reticulum.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Oct-06, Volume: 24, Issue:40

    Topics: Animals; Cell Line; Child; Diazepam; Electric Conductivity; Endoplasmic Reticulum; Epilepsy, Absence

2004
[Animal and clinical studies on rectal administration of a mixed solution of ibuprofen and diazepam].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2005, Volume: 43, Issue:4

    Topics: Administration, Rectal; Animals; Child; Child, Preschool; Diazepam; Drug Therapy, Combination; Human

2005
Evaluation and treatment of the child with febrile seizure.
    American family physician, 2006, May-15, Volume: 73, Issue:10

    Topics: Anticonvulsants; Child; Diazepam; Humans; Risk Factors; Seizures, Febrile

2006
Comment on childhood febrile seizures: overview and implications by Tonia Jones and Steven J. Jacobsen.
    International journal of medical sciences, 2007, Oct-15, Volume: 4, Issue:5

    Topics: Child; Diazepam; Humans; Prognosis; Seizures, Febrile

2007
Febrile convulsions: a suitable case for treatment?
    Lancet (London, England), 1980, Sep-27, Volume: 2, Issue:8196

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Risk; Seizures; Seizures, Febrile

1980
[Diazepam and febrile convulsions in children].
    Presse medicale (Paris, France : 1983), 1983, Jan-29, Volume: 12, Issue:4

    Topics: Diazepam; Humans; Infant; Seizures, Febrile

1983
[Continuous oral phenobarbital or intermittent rectal diazepam for the prevention of febrile convulsions].
    Anales espanoles de pediatria, 1984, Volume: 20, Issue:8

    Topics: Administration, Oral; Child, Preschool; Diazepam; Female; Humans; Infant; Longitudinal Studies; Male

1984
[Prevention of febrile convulsions and kinetics of diazepam per os].
    Archives francaises de pediatrie, 1984, Volume: 41, Issue:8

    Topics: Child, Preschool; Diazepam; Humans; Infant; Kinetics; Recurrence; Seizures, Febrile

1984
[Management of febrile convulsions in children].
    Revue de l'infirmiere, 1983, Volume: 33, Issue:16

    Topics: Child; Child, Preschool; Diazepam; Humans; Infant; Seizures, Febrile

1983
Prophylaxis and febrile convulsions.
    Archives of disease in childhood, 1981, Volume: 56, Issue:2

    Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Se

1981
ABC of 1 to 7. Febrile convulsions.
    British medical journal (Clinical research ed.), 1982, May-01, Volume: 284, Issue:6325

    Topics: Body Temperature; Child, Preschool; Diazepam; Emergencies; Humans; Infant; Paraldehyde; Prognosis; S

1982
["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis].
    Fortschritte der Medizin, 1982, Jun-24, Volume: 100, Issue:24

    Topics: Child, Preschool; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Parents; Phenobarbita

1982
Rectal diazepam in the management of febrile convulsions.
    Developmental medicine and child neurology, 1983, Volume: 25, Issue:2

    Topics: Child; Child, Preschool; Diazepam; Humans; Seizures, Febrile

1983
[Treatment of febrile convulsions. New data and new options].
    Helvetica paediatrica acta, 1982, Volume: 37, Issue:1

    Topics: Anticonvulsants; Chloral Hydrate; Diazepam; Humans; Recurrence; Seizures, Febrile

1982
Home treatment of seizures as a strategy for the long-term management of febrile convulsions in children.
    Helvetica paediatrica acta, 1982, Volume: 37, Issue:6

    Topics: Child; Child, Preschool; Diazepam; Enema; Home Nursing; Humans; Infant; Patient Compliance; Seizures

1982
[The treatment of febrile convulsions].
    Nederlands tijdschrift voor geneeskunde, 1981, Jun-06, Volume: 125, Issue:23

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Rectum; Seizures; Seizures, Febrile

1981
Treatment of febrile seizures.
    The Journal of pediatrics, 1980, Volume: 96, Issue:3 Pt 1

    Topics: Child, Preschool; Diazepam; Female; Humans; Male; Patient Compliance; Seizures; Seizures, Febrile

1980
The first year of life. Convulsions in the older infant.
    British medical journal, 1980, Apr-26, Volume: 280, Issue:6222

    Topics: Diazepam; First Aid; Humans; Hyaluronoglucosaminidase; Infant; Paraldehyde; Phenobarbital; Seizures;

1980
Childhood convulsions in the tropics.
    Tropical doctor, 1980, Volume: 10, Issue:3

    Topics: Child, Preschool; Chloral Hydrate; Diazepam; Humans; Infant; Medicine, Traditional; Rural Health; Se

1980
Febrile seizures: long-term management of children with fever-associated seizures. Summary of an NIH consensus statement.
    British medical journal, 1980, Jul-26, Volume: 281, Issue:6235

    Topics: Child, Preschool; Diazepam; Epilepsy; Fever; Humans; Infant; Phenobarbital; Risk; Seizures; Seizures

1980
[Treatment of febrile convulsions in infants].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1995, Volume: 2, Issue:8

    Topics: Anticonvulsants; Diazepam; Humans; Infant; Recurrence; Seizures, Febrile; Valproic Acid

1995
Prevention of recurrent febrile seizures.
    The Journal of pediatrics, 1995, Volume: 126, Issue:6

    Topics: Acetaminophen; Child; Diazepam; Humans; Recurrence; Seizures, Febrile

1995
Blood levels of diazepam after single rectal administration in children.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1993, Volume: 76 Suppl 2

    Topics: Administration, Rectal; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Prospective Studie

1993
Diazepam to prevent febrile seizures.
    The New England journal of medicine, 1993, Dec-30, Volume: 329, Issue:27

    Topics: Anxiety; Child; Diazepam; Humans; Parents; Seizures, Febrile

1993
Diazepam to prevent febrile seizures.
    The New England journal of medicine, 1993, Dec-30, Volume: 329, Issue:27

    Topics: Ataxia; Child; Diazepam; Humans; Seizures, Febrile

1993
Diazepam to prevent febrile seizures.
    The New England journal of medicine, 1993, Dec-30, Volume: 329, Issue:27

    Topics: Child; Diazepam; Humans; Seizures, Febrile

1993
Diazepam to prevent febrile seizures.
    The New England journal of medicine, 1993, Dec-30, Volume: 329, Issue:27

    Topics: Child; Diazepam; Humans; Patient Education as Topic; Seizures, Febrile

1993
Diazepam to prevent febrile seizures.
    The New England journal of medicine, 1993, Dec-30, Volume: 329, Issue:27

    Topics: Child; Diazepam; Electroencephalography; Epilepsy; Humans; Seizures, Febrile

1993
[Oral administration of diazepam for the prevention of febrile convulsions in young children].
    Deutsche medizinische Wochenschrift (1946), 1993, Dec-17, Volume: 118, Issue:50

    Topics: Administration, Rectal; Child, Preschool; Diazepam; Humans; Infant; Seizures, Febrile

1993
Short-term prophylaxis of febrile convulsions by oral diazepam.
    Acta paediatrica (Oslo, Norway : 1992), 1993, Volume: 82, Issue:1

    Topics: Administration, Oral; Child, Preschool; Diazepam; Humans; Infant; Patient Compliance; Prospective St

1993
Diazepam to reduce recurrences of febrile seizures.
    The Journal of pediatrics, 1996, Volume: 128, Issue:2

    Topics: Administration, Oral; Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Recurrence; Seizu

1996
[Incidence of fever convulsions in 3-72-month-old children].
    Nederlands tijdschrift voor geneeskunde, 1996, May-25, Volume: 140, Issue:21

    Topics: Child; Child, Preschool; Diazepam; Humans; Infant; Seizures, Febrile

1996
[Intermittent prophylaxis in febrile seizures with oral diazepam: study of 82 cases].
    Arquivos de neuro-psiquiatria, 1996, Volume: 54, Issue:2

    Topics: Child, Preschool; Diazepam; Female; Humans; Infant; Male; Prospective Studies; Recurrence; Respite C

1996
[Efficacy of rectal diazepam suppository in the prophylaxis of febrile seizures: comparison with rectal chloral hydrate suppository].
    No to hattatsu = Brain and development, 1997, Volume: 29, Issue:4

    Topics: Child; Child, Preschool; Chloral Hydrate; Diazepam; Female; Humans; Infant; Male; Recurrence; Seizur

1997
Contradictory conclusions about the possible effects of prolonged febrile convulsions.
    Epilepsia, 1998, Volume: 39, Issue:1

    Topics: Brain; Diazepam; Disease Progression; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Compl

1998
Gaining a perspective on childhood seizures.
    The New England journal of medicine, 1998, Jun-25, Volume: 338, Issue:26

    Topics: Administration, Rectal; Adult; Child; Diazepam; Epilepsy; Humans; Recurrence; Seizures, Febrile

1998
Pros and cons of treatments and studies of recurrent febrile seizures.
    The Journal of pediatrics, 1998, Volume: 133, Issue:5

    Topics: Anticonvulsants; Child; Diazepam; Humans; Randomized Controlled Trials as Topic; Recurrence; Seizure

1998
Technical report: treatment of the child with simple febrile seizures.
    Pediatrics, 1999, Volume: 103, Issue:6

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe

1999
[Febrile convulsions and other occasional convulsions in children].
    La Revue du praticien, 1999, Sep-15, Volume: 49, Issue:14

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Genetic Predisposition to Disease; Humans; Infant; Prog

1999
Febrile convulsions: acute seizure characteristics and anti-convulsant therapy.
    Annals of tropical paediatrics, 2000, Volume: 20, Issue:3

    Topics: Acute Disease; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Hospitalization; Humans;

2000
Intranasal midazolam for treating febrile seizures in children. Buccal midazolam for childhood seizures at home preferred to rectal diazepam.
    BMJ (Clinical research ed.), 2001, Jan-13, Volume: 322, Issue:7278

    Topics: Administration, Oral; Administration, Rectal; Anticonvulsants; Child; Diazepam; Humans; Midazolam; S

2001
Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures.
    Nature genetics, 2001, Volume: 28, Issue:1

    Topics: Age of Onset; Anticonvulsants; Child; Chromosome Segregation; Diazepam; Electrophysiology; Epilepsy,

2001
Febrile seizures.
    Pediatric emergency care, 2001, Volume: 17, Issue:5

    Topics: Anticonvulsants; Child; Diazepam; Humans; Risk Factors; Seizures, Febrile

2001
Treatment of febrile seizures: the influence of treatment efficacy and side-effect profile on value to parents.
    Pediatrics, 2001, Volume: 108, Issue:5

    Topics: Adult; Anticonvulsants; Anxiety; Attitude; Child, Preschool; Diazepam; Educational Status; Female; H

2001
[Treatment of febrile convulsions].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2002, Volume: 9, Issue:1

    Topics: Age Factors; Analgesics, Non-Narcotic; Anticonvulsants; Carbamazepine; Child, Preschool; Diazepam; D

2002
[Proposed immunization program for febrile seizures(discussion)].
    No to hattatsu = Brain and development, 2002, Volume: 34, Issue:2

    Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Female; Humans; Immunization Programs; Infant;

2002
Prophylactic diazepam in febrile convulsions.
    Archives of disease in childhood, 1979, Volume: 54, Issue:3

    Topics: Child; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Seizures; Seizures, Febrile

1979
[Intermittent prophylaxis of febrile convulsions with diazepam].
    Minerva pediatrica, 1979, Mar-15, Volume: 31, Issue:5

    Topics: Child, Preschool; Diazepam; Drug Evaluation; Female; Follow-Up Studies; Humans; Infant; Male; Recurr

1979
Antipyretic effect and plasma concentrations of rectal acetaminophen and diazepam in children.
    Epilepsia, 1979, Volume: 20, Issue:6

    Topics: Acetaminophen; Body Temperature; Child; Child, Preschool; Diazepam; Drug Therapy, Combination; Fever

1979
Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children.
    Archives of disease in childhood, 1979, Volume: 54, Issue:11

    Topics: Acute Disease; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Prospective Studies; Rectum; Se

1979
[Febrile convulsions in children].
    Duodecim; laaketieteellinen aikakauskirja, 1978, Volume: 94, Issue:21

    Topics: Child, Preschool; Diazepam; Humans; Infant; Paraldehyde; Seizures; Seizures, Febrile

1978
Febrile convulsions--what do parents do?
    British medical journal, 1978, Nov-11, Volume: 2, Issue:6148

    Topics: Attitude; Child; Child, Preschool; Diazepam; Female; Home Nursing; Hospitalization; Humans; Infant;

1978
Preventing febrile convulsions.
    Developmental medicine and child neurology, 1978, Volume: 20, Issue:6

    Topics: Child, Preschool; Diazepam; Humans; Infant; Phenobarbital; Seizures; Seizures, Febrile

1978
[Acute treatment with diazepam].
    Lakartidningen, 1977, Mar-16, Volume: 74, Issue:11

    Topics: Child; Child, Preschool; Diazepam; Humans; Seizures; Seizures, Febrile

1977
[The etiology and therapy of febrile convulsive attacks in the infant age].
    Ceskoslovenska pediatrie, 1976, Volume: 31, Issue:11

    Topics: Age Factors; Diazepam; Humans; Infant; Infant, Newborn; Seizures; Seizures, Febrile

1976
[Intermittent prophylaxis in febrile convulsions with oral diazepam].
    Arquivos de neuro-psiquiatria, 1992, Volume: 50, Issue:2

    Topics: Administration, Oral; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Male; Prospective S

1992
Diazepam for prevention of recurrence of febrile seizures.
    The Journal of pediatrics, 1991, Volume: 119, Issue:2

    Topics: Child; Diazepam; Drug Evaluation; Humans; Recurrence; Seizures, Febrile

1991
Convulsions in the older infant.
    BMJ (Clinical research ed.), 1990, Jan-13, Volume: 300, Issue:6717

    Topics: Anticonvulsants; Child; Diazepam; Humans; Infant; Seizures, Febrile

1990
[Febrile convulsions].
    Wiener medizinische Wochenschrift (1946), 1989, Sep-30, Volume: 139, Issue:18

    Topics: Child, Preschool; Diazepam; Encephalitis; Humans; Infant; Meningitis; Risk Factors; Seizures, Febril

1989
Behaviour and confidence of parents instructed in home management of febrile seizures by rectal diazepam.
    Helvetica paediatrica acta, 1989, Volume: 43, Issue:4

    Topics: Administration, Rectal; Attitude to Health; Child, Preschool; Diazepam; Home Nursing; Humans; Infant

1989
Home use of rectal diazepam to prevent status epilepticus in children with convulsive disorders.
    Journal of child neurology, 1989, Volume: 4, Issue:2

    Topics: Administration, Rectal; Adolescent; Child; Child, Preschool; Diazepam; Follow-Up Studies; Home Nursi

1989
[Febrile seizures].
    Duodecim; laaketieteellinen aikakauskirja, 1987, Volume: 103, Issue:15

    Topics: Adolescent; Carbamates; Child; Child, Preschool; Diazepam; Female; Humans; Male; Risk Factors; Seizu

1987
Febrile convulsions in childhood.
    Australian family physician, 1987, Volume: 16, Issue:4

    Topics: Anesthesia, General; Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Seizures, Febrile

1987
Pharmacokinetics of rectal diazepam in the prevention of recurrent febrile convulsions.
    Brain & development, 1986, Volume: 8, Issue:1

    Topics: Diazepam; Dose-Response Relationship, Drug; Humans; Infant; Kinetics; Prognosis; Rectum; Recurrence;

1986
[A clinical study on the effectiveness of intermittent therapy using oral diazepam syrups for the prevention of recurrent febrile convulsions: a preliminary report].
    No to hattatsu = Brain and development, 1986, Volume: 18, Issue:3

    Topics: Child, Preschool; Diazepam; Humans; Infant; Seizures, Febrile

1986
Prophylaxis of febrile convulsions: searching for the best.
    Archives of disease in childhood, 1986, Volume: 61, Issue:6

    Topics: Child, Preschool; Diazepam; Humans; Infant; Seizures, Febrile

1986
The management of febrile convulsions.
    Drug and therapeutics bulletin, 1987, Feb-09, Volume: 25, Issue:3

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Seizures, Febrile

1987
[A pharmacokinetic study on the effectiveness of intermittent oral diazepam in the prevention of recurrent febrile convulsions].
    No to hattatsu = Brain and development, 1985, Volume: 17, Issue:2

    Topics: Administration, Oral; Child, Preschool; Diazepam; Humans; Infant; Recurrence; Seizures, Febrile; Sup

1985
[Optimum dosage regimen of intermittent oral diazepam for the prevention of recurrent febrile convulsions--pharmacokinetics of diazepam after repeated oral administration].
    No to hattatsu = Brain and development, 1985, Volume: 17, Issue:4

    Topics: Administration, Oral; Diazepam; Humans; Infant; Kinetics; Seizures, Febrile

1985
[Convulsive crises in childhood].
    Anales espanoles de pediatria, 1985, Volume: 23, Issue:8

    Topics: Clonazepam; Crying; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Mi

1985