Page last updated: 2024-10-25

diazepam and Reperfusion Injury

diazepam has been researched along with Reperfusion Injury in 4 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.

Research Excerpts

ExcerptRelevanceReference
"The protective effect and mechanism of diazepam on ischemia neurons during cerebral ischemia and reperfusion were studied."7.71Effect of diazepam on the contents of amino acids and free radical during ischemia/reperfusion injury. ( Hu, B; Mei, Y; Qiu, X; Sun, S; Tong, E; Wei, G, 2001)
"The results show that repeated administration of diazepam (5 mg/kg for 5 days) reduced the cardiac performance in reperfusion, and significantly exacerbated the ischemia-reperfusion injury."3.75The effect of repeated diazepam administration on myocardial function in the ischemia-reperfused isolated rat heart. ( Godini, A; Kayhani, B; Pourshanazari, A; Reshadat, S; Shackebaei, D, 2009)
"The protective effect and mechanism of diazepam on ischemia neurons during cerebral ischemia and reperfusion were studied."3.71Effect of diazepam on the contents of amino acids and free radical during ischemia/reperfusion injury. ( Hu, B; Mei, Y; Qiu, X; Sun, S; Tong, E; Wei, G, 2001)
"Mannitol flux was greater in ischemic tissues than in reperfused tissues."1.37In vitro and in vivo responses of mucosa from the large colon of horses to ischemia and reperfusion. ( Freeman, DE; Graham, AS; Grosche, A; Morton, AJ; Polyak, MM, 2011)
"Reperfusion hyperalgesia manifested as a decrease in tail flick latency, following tail immersion in 49 degrees C water, after the release of the tourniquet."1.29Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines. ( Cartmell, SM; Mitchell, D, 1993)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shackebaei, D1
Kayhani, B1
Godini, A1
Pourshanazari, A1
Reshadat, S1
Graham, AS1
Grosche, A1
Morton, AJ1
Polyak, MM1
Freeman, DE1
Cartmell, SM1
Mitchell, D1
Hu, B1
Mei, Y1
Wei, G1
Qiu, X1
Sun, S1
Tong, E1

Other Studies

4 other studies available for diazepam and Reperfusion Injury

ArticleYear
The effect of repeated diazepam administration on myocardial function in the ischemia-reperfused isolated rat heart.
    Saudi medical journal, 2009, Volume: 30, Issue:6

    Topics: Animals; Diazepam; Heart; In Vitro Techniques; Male; Rats; Rats, Wistar; Reperfusion Injury

2009
In vitro and in vivo responses of mucosa from the large colon of horses to ischemia and reperfusion.
    American journal of veterinary research, 2011, Volume: 72, Issue:7

    Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Colon; Diazepam; Electric Impedance; Horse

2011
Attenuation of reperfusion hyperalgesia in the rat by systemic administration of benzodiazepines.
    British journal of pharmacology, 1993, Volume: 110, Issue:3

    Topics: Animals; Behavior, Animal; Benzodiazepines; Chlordiazepoxide; Depression, Chemical; Diazepam; Dose-R

1993
Effect of diazepam on the contents of amino acids and free radical during ischemia/reperfusion injury.
    Journal of Tongji Medical University = Tong ji yi ke da xue xue bao, 2001, Volume: 21, Issue:2

    Topics: Amino Acids; Animals; Brain Ischemia; Diazepam; Free Radicals; GABA Modulators; Male; Rats; Rats, Wi

2001
chemdatabank.com