diazepam has been researched along with Recrudescence in 110 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this phase III, randomized, double‐blind, parallel‐group, placebo‐controlled, multicenter study, subjects with epilepsy on a stable antiepileptic drug regimen who required intermittent medical intervention to control ARS were randomized 1:1 to the placebo AI or the diazepam AI group." | 9.17 | A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures. ( Abou-Khalil, B; Goli, V; Pixton, GC; Rogin, J; Roland, CL; Sherman, NA; Shukla, RB; Sommerville, K; Wheless, J; Wolter, KD, 2013) |
| "To evaluate the efficacy and tolerability of diazepam (DZP) rectal gel (Diastat; Elan Pharmaceuticals, Dublin, Ireland) for the treatment of acute repetitive seizures in adult patients in 2 multicenter, double-blind, placebo-controlled parallel studies." | 9.10 | Rectal diazepam gel for treatment of acute repetitive seizures in adults. ( Cereghino, JJ; Cloyd, JC; Kuzniecky, RI, 2002) |
| "The purpose of these investigations was to determine from combined data the response to rectal diazepam (DZP) gel (Diastat [Athena Neurosciences, South San Francisco, CA]) in home treatment of children with episodes of acute repetitive seizures (ARS)." | 9.09 | Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group. ( Cereghino, JJ; Cloyd, JC; Kriel, RL; Mitchell, WG; Pellock, JM; Rosman, NP, 1999) |
| "This clinical trial was conducted to compare the anticonvulsant response of magnesium sulphate and diazepam in the management of eclampsia." | 9.08 | Magnesium sulphate versus diazepam in the management of eclampsia. ( Hussain, AZ; Khan, JH; Rouf, S; Samsuddin, AK; Shamsuddin, L; Tamanna, S, 1998) |
| "To compare treatment of ongoing seizures using intramuscular (IM) midazolam versus intravenous (IV) diazepam." | 9.08 | A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children. ( Altieri, MA; Chamberlain, JM; Futterman, C; Ochsenschlager, DW; Waisman, Y; Young, GM, 1997) |
| "This study was undertaken to evaluate the efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen in comparison with as-needed acetaminophen alone for prevention of seizure recurrence during the same fever episode in suspected pediatric simple febrile seizures (SFS)." | 8.12 | Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures. ( Fujita, S; Hataya, H; Kishibe, S; Miyama, S; Morikawa, EK; Morikawa, Y; Narita, K; Sammori, H; Suzuki, S; Takehira, K; Tanaka, M; Tsukamoto, J; Wang, Q; Yano, M, 2022) |
| "Minocycline attenuates alcohol withdrawal anxiety and disrupts alcohol relapse." | 7.88 | Minocycline in Alcohol Withdrawal Induced Anxiety and Alcohol Relapse in Rats. ( Gajbhiye, SV; Petare, A; Potey, AV; Shankar, A; Tripathi, RK, 2018) |
| "To determine whether lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus." | 7.83 | Lorazepam v. diazepam for pediatric status epilepticus. ( Pinto, RF; Turnbull, J, 2016) |
| "Lidocaine (lignocaine) was given in 42 episodes of status epilepticus (SE) in 36 patients either because of limited pulmonary reserve (22 patients) or because of lack of response to diazepam (14 patients)." | 7.68 | Role of lidocaine (lignocaine) in managing status epilepticus. ( Berciano, J; Ciudad, J; Pascual, J, 1992) |
| "Seventeen children (age range 2 weeks to 15 years) who developed status epilepticus were treated with intravenous clonazepam (Rivotril)." | 7.66 | Intravenous clonazepam in the treatment of status epilepticus in children. ( Congdon, PJ; Forsythe, WI, 1980) |
| "Diastat treatment reduced median seizure frequency (p = 0." | 6.69 | Treating repetitive seizures with a rectal diazepam formulation: a randomized study. The North American Diastat Study Group. ( Cereghino, JJ; Kriel, RL; Mitchell, WG; Murphy, J; Rosenfeld, WE; Trevathan, E, 1998) |
| "Benzodiazepines are used as first-line treatments for status epilepticus." | 5.46 | Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus. ( Daidoji, H; Doi, K; Hashimoto, H; Hiruma, T; Inokuchi, R; Morimura, N; Nakamura, K; Naraba, H; Sonoo, T; Tokunaga, K, 2017) |
| "Mexiletine has a little first pass hepatic metabolism and a large volume of distribution along with a high lipid solubility, and prolonged central nervous system toxicity may be expected." | 5.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| "In this phase III, randomized, double‐blind, parallel‐group, placebo‐controlled, multicenter study, subjects with epilepsy on a stable antiepileptic drug regimen who required intermittent medical intervention to control ARS were randomized 1:1 to the placebo AI or the diazepam AI group." | 5.17 | A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures. ( Abou-Khalil, B; Goli, V; Pixton, GC; Rogin, J; Roland, CL; Sherman, NA; Shukla, RB; Sommerville, K; Wheless, J; Wolter, KD, 2013) |
| "To evaluate the efficacy and tolerability of diazepam (DZP) rectal gel (Diastat; Elan Pharmaceuticals, Dublin, Ireland) for the treatment of acute repetitive seizures in adult patients in 2 multicenter, double-blind, placebo-controlled parallel studies." | 5.10 | Rectal diazepam gel for treatment of acute repetitive seizures in adults. ( Cereghino, JJ; Cloyd, JC; Kuzniecky, RI, 2002) |
| "The purpose of these investigations was to determine from combined data the response to rectal diazepam (DZP) gel (Diastat [Athena Neurosciences, South San Francisco, CA]) in home treatment of children with episodes of acute repetitive seizures (ARS)." | 5.09 | Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group. ( Cereghino, JJ; Cloyd, JC; Kriel, RL; Mitchell, WG; Pellock, JM; Rosman, NP, 1999) |
| "This clinical trial was conducted to compare the anticonvulsant response of magnesium sulphate and diazepam in the management of eclampsia." | 5.08 | Magnesium sulphate versus diazepam in the management of eclampsia. ( Hussain, AZ; Khan, JH; Rouf, S; Samsuddin, AK; Shamsuddin, L; Tamanna, S, 1998) |
| "To compare treatment of ongoing seizures using intramuscular (IM) midazolam versus intravenous (IV) diazepam." | 5.08 | A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children. ( Altieri, MA; Chamberlain, JM; Futterman, C; Ochsenschlager, DW; Waisman, Y; Young, GM, 1997) |
| " Diazepam, administered only during episodes of fever, may be a safe, effective agent to prevent the recurrence of febrile seizures." | 5.07 | A controlled trial of diazepam administered during febrile illnesses to prevent recurrence of febrile seizures. ( Colton, T; Gardella, NB; Gilbert, PL; Kaye, EM; Labazzo, J; Rosman, NP; Van Bennekom, C; Winter, MR, 1993) |
| " Intermittent diazepam prophylaxis at times of fever may or may not reduce the recurrence rate significantly, but there is no data to suggest that it improves the long-term outcome, as compared with short-term seizure control, in terms of IQ, cognition, academic progress, motor control, and subsequent epilepsy." | 4.81 | [Febrile convulsions, Treatment and prognosis]. ( Knudsen, FU, 2001) |
| "This study was undertaken to evaluate the efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen in comparison with as-needed acetaminophen alone for prevention of seizure recurrence during the same fever episode in suspected pediatric simple febrile seizures (SFS)." | 4.12 | Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures. ( Fujita, S; Hataya, H; Kishibe, S; Miyama, S; Morikawa, EK; Morikawa, Y; Narita, K; Sammori, H; Suzuki, S; Takehira, K; Tanaka, M; Tsukamoto, J; Wang, Q; Yano, M, 2022) |
| "Minocycline attenuates alcohol withdrawal anxiety and disrupts alcohol relapse." | 3.88 | Minocycline in Alcohol Withdrawal Induced Anxiety and Alcohol Relapse in Rats. ( Gajbhiye, SV; Petare, A; Potey, AV; Shankar, A; Tripathi, RK, 2018) |
| "To determine whether lorazepam has better efficacy and safety than diazepam for treating pediatric status epilepticus." | 3.83 | Lorazepam v. diazepam for pediatric status epilepticus. ( Pinto, RF; Turnbull, J, 2016) |
| "The lorazepam-diazepam protocol was mostly effective in managing relapses and recurrences of catatonia." | 3.83 | Relapses and recurrences of catatonia: 30-case analysis and literature review. ( Huang, TL; Hung, YY; Lin, CC; Tsai, MC, 2016) |
| " Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P < 0." | 3.79 | Hypoxia markers are expressed in interneurons exposed to recurrent seizures. ( Biagini, G; Gualtieri, F; Longo, D; Marinelli, C; Meletti, S; Nichelli, PF; Pugnaghi, M, 2013) |
| "Diazepam is administered to children in status epilepticus by paramedics in many Emergency Medical Services systems throughout the United States despite the lack of clear evidence that this therapy is safe and effective when employed in the prehospital environment." | 3.69 | Effect of prehospital treatment on the outcome of status epilepticus in children. ( Alldredge, BK; Ferriero, DM; Wall, DB, 1995) |
| "Lidocaine (lignocaine) was given in 42 episodes of status epilepticus (SE) in 36 patients either because of limited pulmonary reserve (22 patients) or because of lack of response to diazepam (14 patients)." | 3.68 | Role of lidocaine (lignocaine) in managing status epilepticus. ( Berciano, J; Ciudad, J; Pascual, J, 1992) |
| "Seventeen children (age range 2 weeks to 15 years) who developed status epilepticus were treated with intravenous clonazepam (Rivotril)." | 3.66 | Intravenous clonazepam in the treatment of status epilepticus in children. ( Congdon, PJ; Forsythe, WI, 1980) |
| "Hematoma recurrence was not detected in the etizolam group 3 months after surgery, but occurred in the control group." | 2.70 | Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography. ( Endo, S; Hamada, H; Hayashi, N; Hirashima, Y; Kuwayama, N, 2002) |
| "Diastat treatment reduced median seizure frequency (p = 0." | 2.69 | Treating repetitive seizures with a rectal diazepam formulation: a randomized study. The North American Diastat Study Group. ( Cereghino, JJ; Kriel, RL; Mitchell, WG; Murphy, J; Rosenfeld, WE; Trevathan, E, 1998) |
| " Patients were randomly assigned to receive either rectal diazepam gel, at a dosage varying from 0." | 2.69 | A comparison of rectal diazepam gel and placebo for acute repetitive seizures. ( Bell, WE; Bergen, DC; Cloyd, JC; Conry, JA; Dreifuss, FE; Kuzniecky, RI; Lo, WD; Matsuo, F; Pellock, JM; Rosman, NP; Sharp, GB, 1998) |
| "Acetaminophen had no effect on the recurrence rate." | 2.68 | Effect of acetaminophen and of low intermittent doses of diazepam on prevention of recurrences of febrile seizures. ( Kurttila, R; Rantala, H; Uhari, M; Vainionpää, L, 1995) |
| "Treatment with diazepam has recently been gaining favor, particularly because of reported adverse effects of progestins." | 2.67 | Comparison of diazepam with progestin for effectiveness in suppression of urine spraying behavior in cats. ( Cooper, L; Hart, BL, 1992) |
| "Rebound anxiety and withdrawal symptoms were identified in a substantial minority of patients." | 2.67 | Controlled discontinuation of benzodiazepine treatment for patients with panic disorder. ( Cook, B; Garvey, MJ; Noyes, R; Suelzer, M, 1991) |
| "The number of complex recurrences, however, were significantly higher in the valproic acid group than in the diazepam group." | 2.67 | Intermittent prophylaxis in febrile convulsions: diazepam or valproic acid? ( Ankerhus, J; Brems, M; Daugbjerg, P; Knudsen, FU; Mai, J, 1990) |
| "Diazepam treatment led to a return of the patient's usual condition in seven of 11 episodes." | 2.66 | Diazepam treatment of early symptoms of schizophrenic relapse. ( Buchanan, RW; Carpenter, WT; Jauch, D; Kirkpatrick, B; Waltrip, RW, 1989) |
| "Only about half of all children with febrile convulsions need treatment and follow-up according to these criteria." | 2.66 | Prophylactic treatment with valproic acid or diazepam in children with febrile convulsions. ( Hvorslev, V; Lee, K; Taudorf, K, 1986) |
| "The 18 month recurrence rate was 80 to 100% if three to five risk factors were present, 50% if two factors were identified, 25% where one factor was found, and 12% if there were no predictors." | 2.66 | Recurrence risk after first febrile seizure and effect of short term diazepam prophylaxis. ( Knudsen, FU, 1985) |
| "After their first episode of febrile convulsions, 195 previously healthy children, aged 6--30 months, were given either diazepam or phenobarbitone for a year." | 2.64 | Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study. ( Knudsen, FU; Vestermark, S, 1978) |
| "For most febrile seizures, whether simple or complex, education and counseling are the primary modes of treatment." | 2.42 | Febrile seizures. ( O'Dell, C; Shinnar, S, 2004) |
| "Recurrences are common." | 2.42 | [Febrile seizures--an update]. ( Püst, B, 2004) |
| "The greatest problem with combined treatment is relapse after drug discontinuance." | 2.40 | Benzodiazepines and exposure-based cognitive behavior therapies for panic disorder: conclusions from combined treatment trials. ( Bruce, TJ; Spiegel, DA, 1997) |
| "The risk of recurrences was significantly lower in children receiving continuous phenobarbital therapy than placebo (odds ratio 0." | 2.40 | A meta-analytic review of the preventive treatment of recurrences of febrile seizures. ( Rantala, H; Tarkka, R; Uhari, M, 1997) |
| "Acute treatment of breakthrough seizures and clusters of seizures at home with rectal BZDs (usually DZP, 0." | 2.39 | Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996) |
| "Febrile seizures are a common problem." | 2.37 | Febrile seizures: emergency department diagnosis and treatment. ( Ater, SB; Bettis, DB, 1985) |
| "Acute encephalitis was found in 2 of 8 patients (25%) with FSs prolonged ≥30 min and 2 of 3 patients (67%) requiring ≥2 intravenous anticonvulsants to stop seizures." | 1.72 | Risk factors for acute encephalitis and early seizure recurrence in complex febrile seizures. ( Kajiwara, K; Koga, H, 2022) |
| "Benzodiazepines are used as first-line treatments for status epilepticus." | 1.46 | Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus. ( Daidoji, H; Doi, K; Hashimoto, H; Hiruma, T; Inokuchi, R; Morimura, N; Nakamura, K; Naraba, H; Sonoo, T; Tokunaga, K, 2017) |
| "Seven (21." | 1.40 | Intermittent prophylaxis of recurrent febrile seizures with clobazam versus diazepam. ( Ahmed, AU; Banu, LA; Begum, SA; Haque, MA; Hoque, MR; Karim, MM; Momen, A; Parveen, F; Quddush, MR; Saha, SK; Sattar, S, 2014) |
| "Before treatment with PB, average seizure frequency in PB nonresponders was significantly higher than seizure frequency in responders, which, however, was due to six nonresponders that exhibited > 3 seizures per day." | 1.36 | High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy. ( Brandt, C; Löscher, W, 2010) |
| "Pyridoxine was given intravenously as an antidote." | 1.34 | [Isoniazid intoxication]. ( Cyran, J; Graf, J; Radunz, W; Scheffold, N, 2007) |
| " There was no statistical difference as to the mean dosage of diazepam or chloral hydrate between the patients with and without recurrence." | 1.30 | [Efficacy of rectal diazepam suppository in the prophylaxis of febrile seizures: comparison with rectal chloral hydrate suppository]. ( Kuremoto, K; Oyama, S; Shimazaki, S, 1997) |
| "Simple febrile seizures that occur in children ages 6 months to 5 years are common events with few adverse outcomes." | 1.30 | Technical report: treatment of the child with simple febrile seizures. ( Baumann, RJ, 1999) |
| "Hypsarrhythmia was symmetrical and, after intravenous diazepam (4 patients, 0." | 1.29 | Early clinical and EEG features of infantile spasms in Down syndrome. ( Cieuta, C; Dulac, O; Guerrini, R; Livet, MO; Plouin, P; Silva, ML, 1996) |
| "Mexiletine has a little first pass hepatic metabolism and a large volume of distribution along with a high lipid solubility, and prolonged central nervous system toxicity may be expected." | 1.29 | Mexiletine overdose producing status epilepticus without cardiovascular abnormalities. ( Hoffman, RS; Nelson, LS, 1994) |
| "Preventive treatment of recurrence is mainly indicated in case of complex seizures using either prolonged daily monotherapy, preferentially sodium valproate, or intermittent administration of diazepam during febrile illnesses." | 1.29 | [Treatment of febrile convulsions in infants]. ( Bourrillon, A, 1995) |
| "They have had simple or complex febrile seizures." | 1.29 | [Intermittent prophylaxis in febrile seizures with oral diazepam: study of 82 cases]. ( Costa, M; Guerreiro, MM; Silva, AE; Silva, EA, 1996) |
| "The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG." | 1.29 | Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period. ( Blennow, G; Hellström-Westas, L; Lindroth, M; Rosén, I; Svenningsen, NW, 1995) |
| "Separate episodes of both catatonia and the so-called 'neuroleptic malignant syndrome' (NMS) occurred within the same patient." | 1.28 | Catatonia and the neuroleptic malignant syndrome--a single entity? ( White, DA, 1992) |
| "This recurrence of phlebitis resolved slowly over seven days, with warm soaking and aspirin therapy." | 1.27 | Recurrence of intravenous-diazepam-induced phlebitis from oral diazepam. ( Brandstetter, RD; Gotz, VP, 1983) |
| "Diazepam was found to be as effective as oral phenobarbital in the prevention of new febrile seizures." | 1.27 | [Continuous oral phenobarbital or intermittent rectal diazepam for the prevention of febrile convulsions]. ( Campos-Castelló, J; Careaga Maldonado, J; Oliete García, F, 1984) |
| " Most of the observed plasma diazepam levels were found to be within +/- one standard deviation of the values calculated from the pharmacokinetic parameters in six other infants with single rectal dosing." | 1.27 | Pharmacokinetics of rectal diazepam in the prevention of recurrent febrile convulsions. ( Minagawa, K; Miura, H; Mizuno, S; Shirai, H, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (37.27) | 18.7374 |
| 1990's | 42 (38.18) | 18.2507 |
| 2000's | 13 (11.82) | 29.6817 |
| 2010's | 11 (10.00) | 24.3611 |
| 2020's | 3 (2.73) | 2.80 |
| Authors | Studies |
|---|---|
| Tanaka, M | 2 |
| Wang, Q | 1 |
| Morikawa, Y | 1 |
| Tsukamoto, J | 1 |
| Sammori, H | 1 |
| Takehira, K | 1 |
| Yano, M | 1 |
| Miyama, S | 1 |
| Fujita, S | 1 |
| Narita, K | 1 |
| Kishibe, S | 1 |
| Morikawa, EK | 1 |
| Suzuki, S | 1 |
| Hataya, H | 1 |
| Kajiwara, K | 1 |
| Koga, H | 2 |
| Inoue, M | 1 |
| Adachi, S | 1 |
| Kawakami, I | 1 |
| Nakamura, K | 1 |
| Inokuchi, R | 1 |
| Daidoji, H | 1 |
| Naraba, H | 1 |
| Sonoo, T | 1 |
| Hashimoto, H | 1 |
| Tokunaga, K | 1 |
| Hiruma, T | 1 |
| Doi, K | 1 |
| Morimura, N | 1 |
| Gajbhiye, SV | 1 |
| Tripathi, RK | 1 |
| Petare, A | 1 |
| Potey, AV | 1 |
| Shankar, A | 1 |
| Abou-Khalil, B | 1 |
| Wheless, J | 1 |
| Rogin, J | 1 |
| Wolter, KD | 1 |
| Pixton, GC | 1 |
| Shukla, RB | 1 |
| Sherman, NA | 1 |
| Sommerville, K | 1 |
| Goli, V | 1 |
| Roland, CL | 1 |
| Sattar, S | 1 |
| Saha, SK | 1 |
| Parveen, F | 1 |
| Banu, LA | 1 |
| Momen, A | 1 |
| Ahmed, AU | 1 |
| Quddush, MR | 1 |
| Karim, MM | 1 |
| Begum, SA | 1 |
| Haque, MA | 1 |
| Hoque, MR | 1 |
| Pinto, RF | 1 |
| Turnbull, J | 1 |
| Lin, CC | 1 |
| Hung, YY | 1 |
| Tsai, MC | 1 |
| Huang, TL | 1 |
| Wheless, JW | 1 |
| Shinnar, S | 1 |
| O'Dell, C | 1 |
| Löscher, W | 1 |
| Brandt, C | 1 |
| Khosroshahi, N | 1 |
| Faramarzi, F | 1 |
| Salamati, P | 1 |
| Haghighi, SM | 1 |
| Kamrani, K | 1 |
| Bell, J | 1 |
| Collins, R | 1 |
| Chaleff, S | 1 |
| Hurwitz, CA | 1 |
| Chang, M | 1 |
| Dahl, G | 1 |
| Alonzo, TA | 1 |
| Weinstein, H | 1 |
| Gualtieri, F | 1 |
| Marinelli, C | 1 |
| Longo, D | 1 |
| Pugnaghi, M | 1 |
| Nichelli, PF | 1 |
| Meletti, S | 1 |
| Biagini, G | 1 |
| Cereghino, JJ | 3 |
| Cloyd, JC | 3 |
| Kuzniecky, RI | 2 |
| Riedl, B | 1 |
| Waruiru, C | 1 |
| Appleton, R | 1 |
| Püst, B | 1 |
| Graf, J | 1 |
| Scheffold, N | 1 |
| Radunz, W | 1 |
| Cyran, J | 1 |
| Ali, A | 1 |
| Christian, D | 1 |
| Chung, E | 1 |
| Nakazato, Y | 1 |
| Tamura, N | 1 |
| Shimazu, K | 1 |
| Danilenko, AM | 1 |
| Veselovskiĭ, VV | 1 |
| Kuznetsov, VI | 1 |
| Vorobeĭchik, GN | 1 |
| Tuz, MV | 1 |
| Nishikawa, T | 1 |
| Tsuda, A | 1 |
| Koga, I | 1 |
| Uchida, Y | 1 |
| Chouinard, G | 1 |
| Labonte, A | 1 |
| Fontaine, R | 1 |
| Annable, L | 1 |
| Escorihuela, R | 1 |
| Sandiumenge, J | 1 |
| Procopis, PG | 1 |
| Oliete García, F | 1 |
| Campos-Castelló, J | 1 |
| Careaga Maldonado, J | 1 |
| Benchet, ML | 1 |
| Tardieu, M | 1 |
| Landrieu, P | 1 |
| Taburet, AM | 1 |
| Singlas, E | 1 |
| Katon, RM | 1 |
| Addy, DP | 1 |
| Brandstetter, RD | 1 |
| Gotz, VP | 1 |
| King, LR | 1 |
| Ramesar, S | 1 |
| McCall, M | 1 |
| Holliday, TA | 1 |
| DeSilva, RA | 1 |
| Graboys, TB | 1 |
| Podrid, PJ | 1 |
| Lown, B | 1 |
| Deonna, T | 1 |
| Congdon, PJ | 1 |
| Forsythe, WI | 1 |
| Bourrillon, A | 1 |
| Stores, G | 1 |
| Zaiwalla, Z | 1 |
| Styles, E | 1 |
| Hoshika, A | 1 |
| Alldredge, BK | 1 |
| Wall, DB | 1 |
| Ferriero, DM | 1 |
| Hellström-Westas, L | 1 |
| Blennow, G | 1 |
| Lindroth, M | 1 |
| Rosén, I | 1 |
| Svenningsen, NW | 1 |
| Camfield, PR | 2 |
| Camfield, CS | 2 |
| Gordon, K | 1 |
| Dooley, JM | 1 |
| Uhari, M | 3 |
| Rantala, H | 3 |
| Vainionpää, L | 1 |
| Kurttila, R | 1 |
| Nelson, LS | 1 |
| Hoffman, RS | 1 |
| Rossi, LN | 1 |
| Chiodi, A | 1 |
| Bossi, A | 1 |
| Cortinovis, I | 1 |
| Alberti, S | 1 |
| Rosman, NP | 4 |
| Colton, T | 1 |
| Labazzo, J | 1 |
| Gilbert, PL | 1 |
| Gardella, NB | 1 |
| Kaye, EM | 1 |
| Van Bennekom, C | 1 |
| Winter, MR | 1 |
| Mitchell, WG | 3 |
| Bustillo, J | 1 |
| Buchanan, RW | 2 |
| Carpenter, WT | 2 |
| Silva, ML | 1 |
| Cieuta, C | 1 |
| Guerrini, R | 1 |
| Plouin, P | 1 |
| Livet, MO | 1 |
| Dulac, O | 1 |
| Harrington, ML | 1 |
| Moore, MP | 1 |
| Talcott, PA | 1 |
| Bagley, RS | 1 |
| Sandmeier, P | 1 |
| Costa, M | 1 |
| Silva, EA | 1 |
| Silva, AE | 1 |
| Guerreiro, MM | 1 |
| Chamberlain, JM | 1 |
| Altieri, MA | 1 |
| Futterman, C | 1 |
| Young, GM | 1 |
| Ochsenschlager, DW | 1 |
| Waisman, Y | 1 |
| Spiegel, DA | 1 |
| Bruce, TJ | 1 |
| Shimazaki, S | 1 |
| Kuremoto, K | 1 |
| Oyama, S | 1 |
| Tarkka, R | 2 |
| Pokka, T | 1 |
| Dreifuss, FE | 1 |
| Pellock, JM | 2 |
| Lo, WD | 1 |
| Matsuo, F | 1 |
| Sharp, GB | 1 |
| Conry, JA | 1 |
| Bergen, DC | 1 |
| Bell, WE | 1 |
| Vining, EP | 1 |
| Murphy, J | 1 |
| Kriel, RL | 2 |
| Rosenfeld, WE | 1 |
| Trevathan, E | 1 |
| Watanabe, T | 1 |
| Shafrir, Y | 1 |
| Shamsuddin, L | 1 |
| Rouf, S | 1 |
| Khan, JH | 1 |
| Tamanna, S | 1 |
| Hussain, AZ | 1 |
| Samsuddin, AK | 1 |
| Johnson, KH | 1 |
| Caton, H | 1 |
| Baumann, RJ | 1 |
| Tsujimoto, S | 1 |
| Takemine, K | 1 |
| Sasaki, K | 1 |
| Tashiro, C | 1 |
| Knudsen, FU | 8 |
| Autret-Leca, E | 1 |
| Ployet, JL | 1 |
| Jonville-Bera, AP | 1 |
| Hirashima, Y | 1 |
| Kuwayama, N | 1 |
| Hamada, H | 1 |
| Hayashi, N | 1 |
| Endo, S | 1 |
| Vestermark, S | 2 |
| Borgheresi, S | 1 |
| Luti, E | 1 |
| Buti Cossi, D | 1 |
| Mecherini, L | 1 |
| Bardini, MR | 1 |
| Burgio, E | 1 |
| Ciampi, C | 1 |
| Benocci, M | 1 |
| Massai, S | 1 |
| Lini, M | 1 |
| Grifi, G | 1 |
| Valenza, T | 1 |
| Dianese, GF | 1 |
| Faccioli, G | 1 |
| Wallace, SJ | 2 |
| Noble, AB | 1 |
| McKinney, WT | 1 |
| Mohr, C | 1 |
| Moran, E | 1 |
| Saik, RP | 1 |
| Greenburg, AG | 1 |
| Farris, JM | 1 |
| Peskin, GW | 1 |
| White, DA | 1 |
| Rai, RR | 1 |
| Nijhwawan, S | 1 |
| Bhargava, N | 1 |
| Nepalia, S | 1 |
| Pokharna, DS | 1 |
| Cooper, L | 1 |
| Hart, BL | 1 |
| Pascual, J | 1 |
| Ciudad, J | 1 |
| Berciano, J | 1 |
| DeMuri, G | 1 |
| Langkamp, DL | 1 |
| Noyes, R | 1 |
| Garvey, MJ | 1 |
| Cook, B | 1 |
| Suelzer, M | 1 |
| Crowther, C | 1 |
| Autret, E | 1 |
| Billard, C | 1 |
| Bertrand, P | 1 |
| Motte, J | 1 |
| Pouplard, F | 1 |
| Jonville, AP | 1 |
| Daugbjerg, P | 1 |
| Brems, M | 1 |
| Mai, J | 1 |
| Ankerhus, J | 1 |
| Hakeem, VF | 1 |
| Frankenburg, FR | 1 |
| Kirkpatrick, B | 1 |
| Waltrip, RW | 1 |
| Jauch, D | 1 |
| Roy-Byrne, PP | 1 |
| Dager, SR | 1 |
| Cowley, DS | 1 |
| Vitaliano, P | 1 |
| Dunner, DL | 1 |
| Lee, K | 1 |
| Taudorf, K | 1 |
| Hvorslev, V | 1 |
| Minagawa, K | 2 |
| Miura, H | 2 |
| Mizuno, S | 2 |
| Shirai, H | 2 |
| Bettis, DB | 1 |
| Ater, SB | 1 |
| Rickels, K | 1 |
| Case, WG | 1 |
| Downing, RW | 1 |
| Fridman, R | 1 |
| Lader, MH | 1 |
| Bond, AJ | 1 |
| James, DC | 1 |
| Ferngren, HG | 1 |
| Ouellette, EM | 1 |
| Josephson, DA | 1 |
| Thong, YH | 1 |
| Abramson, DC | 1 |
| Lombroso, CT | 1 |
| Raskin, A | 1 |
| Kaemmerer, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 3, Randomized, Double-blind, Parallel, Placebo-controlled, Multicenter Study, With Optional Open-label Continuation, Of The Efficacy And Safety Of Vanquix(tm) Auto-injector (Diazepam Injection) For The Management Of Selected, Refractory, Patients [NCT00319501] | Phase 3 | 234 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| A Phase IV, Randomized Study to Evaluate the Safety and Efficacy of Idarubicin at Different Dosages Combined With Cytarabine as Induction Therapy for Newly Diagnosed Acute Myeloid Leukaemia[NCT02277847] | Phase 4 | 400 participants (Anticipated) | Interventional | 2010-03-31 | Enrolling by invitation | ||
| Idarubicin and Cladribine in Recurrent and Refractory Acute Myeloid Leukemia: A POG Phase II Study[NCT00003178] | Phase 2 | 120 participants (Actual) | Interventional | 1998-03-31 | Completed | ||
| Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612] | Phase 2 | 358 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| The Efficacy of A Single Dose Clonazepam Compared With the Intermittent Diazepam to Prevent Recurrent Febrile Seizures in Queen Sirikit National Institute of Child Health[NCT04364321] | 74 participants (Anticipated) | Interventional | 2020-05-13 | Recruiting | |||
| Rapid Oral Treatment of Cluster Epileptic Seizures. Efficacy Assessment of Levetiracetam in Cluster Seizures.[NCT00376766] | Phase 3 | 112 participants (Anticipated) | Interventional | 2007-02-28 | Terminated (stopped due to recruitment recruitment recruitment recruitment difficulties) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Caregiver global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes and is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) is defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: Assessments completed at the end of each treated episode of ARS in the Double-blind Period
| Intervention | Units on a scale (Mean) |
|---|---|
| Diazepam | 6.2 |
| Placebo | 5.5 |
Caregiver global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes and is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) is defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: Assessments completed at the end of each treated episode of ARS in the Open-label Period
| Intervention | Units on a scale (Mean) |
|---|---|
| Diazepam | 6.78 |
Physician global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes. The physician global evaluation is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: At Visit 2 and subsequent visits in the Double-blind Period
| Intervention | Units on a scale (Mean) |
|---|---|
| Diazepam | 6.3 |
| Placebo | 5.5 |
Physician global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes and is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) is defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From Visit 2 and subsequent visits in the Open-label Period to discharge or study termination
| Intervention | Units on a scale (Mean) |
|---|---|
| Diazepam | 6.87 |
Any use of emergency treatment (such as an emergency room visit) was recorded in the patient's diary, along with the date, time, and reason for the emergency treatment. Emergency department visits required some type of rescue action taken, other than the visit itself. An episode of acute repetitive seizures (ARS) was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From 15 minutes to 12 hours following study drug administration for onset of an episode of ARS during the Double-blind Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 2 |
| Placebo | 4 |
Any use of emergency treatment (such as an emergency room visit) was recorded in the patient's diary, along with the date, time, and reason for the emergency treatment. Emergency department visits required some type of rescue action taken, other than the visit itself. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for onset of an episode of ARS during the Open-label Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 13 |
Other rescue medical care consisted of care other than rescue medication or emergency department visits. Each patient's specific criteria for seizure and an episode of acute repetitive seizure (ARS) were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for onset of an episode of ARS during the Open-label Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 5 |
Other rescue medical care consisted of care other than rescue medication or emergency department visits. Each patient's specific criteria for seizure and an episode of acute repetitive seizure (ARS) were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. An episode of ARS was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From 15 minutes to 12 hours following study drug administration for an episode of ARS during the Double-blind Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 0 |
| Placebo | 2 |
If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the acute repetitive seizure (ARS) episode. Each patient's specific criteria for seizure and an episode of ARS were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. An episode of ARS was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From 15 minutes to 12 hours following study drug administration for an episode of ARS during the Double-blind Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 14 |
| Placebo | 24 |
Each patient's specific criteria for seizure and an episode of acute repetitive seizure (ARS) were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the ARS episode. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration during the Open-label Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 39 |
An event was defined as an episode of or required rescue medication for an episode of acute repetitive seizures (ARS) within 15 minutes to 12 hours following study drug administration. Patients without an ARS event were censored at 12 hours. Diaries were provided; if no diary was returned, or the diary did not provide answers to questions about seizures and rescue during the 12-hour follow-up period, the patient was considered censored as of 15 minutes past the treatment time, unless another contact was documented. If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the ARS episode. Patients and their caregivers were trained to recognize the onset of an episode of ARS and when and how to administer study drug. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for an episode of ARS during the Double-blind Period
| Intervention | Percentage of participants (Number) |
|---|---|
| Diazepam | 22.4 |
An event was defined as an episode of or required rescue medication for an episode of acute repetitive seizures (ARS) within 15 minutes to 12 hours following study drug administration. Patients without an ARS event were censored at 12 hours. Diaries were provided; if no diary was returned, or the diary did not provide answers to questions about seizures and rescue during the 12-hour follow-up period, the patient was considered censored as of 15 minutes past the treatment time, unless another contact was documented. If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the ARS episode. Patients and their caregivers were trained to recognize the onset of an episode of ARS and when and how to administer study drug. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for an episode of ARS during the Double-blind Period
| Intervention | Hours (Median) |
|---|---|
| Diazepam | 5.92 |
| Placebo | NA |
Length of seizure. (NCT00326612)
Timeframe: 24 hours
| Intervention | Minutes (Median) |
|---|---|
| Intranasal Midazolam | 3.0 |
| Rectal Diazepam | 4.3 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 21 |
| Rectal Diazepam | 17 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 4 |
| Rectal Diazepam | 3 |
(NCT00326612)
Timeframe: 12 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 1 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 5 |
| Rectal Diazepam | 5 |
Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 0 |
Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 3 |
| Rectal Diazepam | 1 |
18 reviews available for diazepam and Recrudescence
| Article | Year |
|---|---|
Treatment of status epilepticus in children.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Administration Schedule; Drug Therapy, Comb | 2004 |
Febrile seizures.
Topics: Age Factors; Anticonvulsants; Child, Preschool; Counseling; Diazepam; Drug Administration Schedule; | 2004 |
Febrile seizures: an update.
Topics: Anticonvulsants; Central Nervous System Diseases; Child; Diazepam; Epilepsy, Temporal Lobe; Humans; | 2004 |
[Febrile seizures--an update].
Topics: Administration, Oral; Administration, Rectal; Age Factors; Analgesics, Non-Narcotic; Anticonvulsants | 2004 |
[Use of phenobarbital in febrile convulsive crisis].
Topics: Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Nervous System Diseases; Phenobarbital; Recurr | 1983 |
Complications of upper gastrointestinal endoscopy in the gastrointestinal bleeder.
Topics: Adult; Aged; Anesthesia, Local; Cardiovascular Diseases; Diazepam; Electrocardiography; Endoscopy; E | 1981 |
Seizure disorders.
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephob | 1980 |
Cardioversion and defibrillation.
Topics: Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Cardiac Catheterization; Diazepa | 1980 |
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea | 1996 |
Prodromal symptoms vs. early warning signs and clinical action in schizophrenia.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Diazepam; Humans; Psychiatric Status Rating Scales; Recur | 1995 |
Management and treatment of febrile seizures.
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Blood Chemical Analysis; Child, Preschool; Diagnosis, Dif | 1997 |
Benzodiazepines and exposure-based cognitive behavior therapies for panic disorder: conclusions from combined treatment trials.
Topics: Agoraphobia; Animals; Benzodiazepines; Clinical Trials as Topic; Cognitive Behavioral Therapy; Combi | 1997 |
A meta-analytic review of the preventive treatment of recurrences of febrile seizures.
Topics: Anticonvulsants; Chi-Square Distribution; Child; Diazepam; Drug Administration Schedule; Fever; Huma | 1997 |
[Febrile convulsions, Treatment and prognosis].
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe | 2001 |
[Prevention of recurrences and of epilepsy in febrile convulsions. Protocol of the Pediatric Clinic of the Florence and preliminary results].
Topics: Age Factors; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; | 1979 |
Febrile seizures: emergency department diagnosis and treatment.
Topics: Blood Cell Count; Blood Glucose; Child, Preschool; Counseling; Diagnosis, Differential; Diazepam; Dr | 1985 |
The child who convulses with fever.
Topics: Age Factors; Analgesics; Brain Injuries; Central Nervous System Diseases; Child; Child Behavior; Chi | 1974 |
The treatment of status epilepticus.
Topics: Anti-Bacterial Agents; Anticonvulsants; Barbiturates; Brain Edema; Central Nervous System Diseases; | 1974 |
32 trials available for diazepam and Recrudescence
| Article | Year |
|---|---|
A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Caregivers; Child; Child, Preschool; Diazepam; Do | 2013 |
Diazepam versus clobazam for intermittent prophylaxis of febrile seizures.
Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Diazepam; Female; Humans; Infant; Male | 2011 |
Phase II study of 2-chlorodeoxyadenosine plus idarubicin for children with acute myeloid leukaemia in first relapse: a paediatric oncology group study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepines; Child; Diazepam; Diseas | 2012 |
Phase II study of 2-chlorodeoxyadenosine plus idarubicin for children with acute myeloid leukaemia in first relapse: a paediatric oncology group study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepines; Child; Diazepam; Diseas | 2012 |
Phase II study of 2-chlorodeoxyadenosine plus idarubicin for children with acute myeloid leukaemia in first relapse: a paediatric oncology group study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepines; Child; Diazepam; Diseas | 2012 |
Phase II study of 2-chlorodeoxyadenosine plus idarubicin for children with acute myeloid leukaemia in first relapse: a paediatric oncology group study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Benzodiazepines; Child; Diazepam; Diseas | 2012 |
Rectal diazepam gel for treatment of acute repetitive seizures in adults.
Topics: Acute Disease; Administration, Rectal; Adolescent; Adult; Aged; Chi-Square Distribution; Diazepam; D | 2002 |
Prophylactic effect of neuroleptics in symptom-free schizophrenics.
Topics: Adult; Antipsychotic Agents; Chlorpromazine; Diazepam; Female; Haloperidol; Humans; Imipramine; Male | 1982 |
New concepts in benzodiazepine therapy: rebound anxiety and new indications for the more potent benzodiazepines.
Topics: Alprazolam; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Bipolar Disorder; Bromazepam; C | 1983 |
Effect of acetaminophen and of low intermittent doses of diazepam on prevention of recurrences of febrile seizures.
Topics: Acetaminophen; Child, Preschool; Diazepam; Double-Blind Method; Drug Administration Schedule; Drug T | 1995 |
A controlled trial of diazepam administered during febrile illnesses to prevent recurrence of febrile seizures.
Topics: Administration, Oral; Child, Preschool; Diazepam; Double-Blind Method; Drug Administration Schedule; | 1993 |
Prodromal symptoms vs. early warning signs and clinical action in schizophrenia.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Diazepam; Humans; Psychiatric Status Rating Scales; Recur | 1995 |
A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children.
Topics: Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Diazepam; Female; Humans; Infant; Inf | 1997 |
Risk of recurrence and outcome after the first febrile seizure.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Drug Therapy, | 1998 |
A comparison of rectal diazepam gel and placebo for acute repetitive seizures.
Topics: Acute Disease; Administration, Rectal; Adolescent; Adult; Child; Child, Preschool; Diazepam; Disease | 1998 |
Treating repetitive seizures with a rectal diazepam formulation: a randomized study. The North American Diastat Study Group.
Topics: Acute Disease; Administration, Rectal; Adolescent; Anticonvulsants; Child; Diazepam; Double-Blind Me | 1998 |
Magnesium sulphate versus diazepam in the management of eclampsia.
Topics: Adult; Anticonvulsants; Blood Pressure; Consciousness; Delivery, Obstetric; Diazepam; Eclampsia; Fem | 1998 |
Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group.
Topics: Acute Disease; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepa | 1999 |
Etizolam, an anti-anxiety agent, attenuates recurrence of chronic subdural hematoma--evaluation by computed tomography.
Topics: Aged; Anti-Anxiety Agents; Diazepam; Female; Follow-Up Studies; Hematoma, Subdural, Chronic; Humans; | 2002 |
[Prevention of febrile convulsions with diazepam or phenemal. A prospective controlled study].
Topics: Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Humans; Infant; Phenobarbital; Prospect | 1978 |
Prophylactic diazepam or phenobarbitone in febrile convulsions: a prospective, controlled study.
Topics: Child, Preschool; Clinical Trials as Topic; Diazepam; Female; Humans; Infant; Male; Phenobarbital; P | 1978 |
Comparison of diazepam with progestin for effectiveness in suppression of urine spraying behavior in cats.
Topics: Animals; Appetite; Ataxia; Behavior, Animal; Cat Diseases; Cats; Diazepam; Female; Male; Medroxyprog | 1992 |
Intermittent diazepam prophylaxis in febrile convulsions. Pros and cons.
Topics: Behavior; Child, Preschool; Diazepam; Drug Administration Schedule; Epilepsy; Humans; Infant; Patien | 1991 |
Controlled discontinuation of benzodiazepine treatment for patients with panic disorder.
Topics: Adult; Alprazolam; Anxiety Disorders; Diazepam; Double-Blind Method; Female; Half-Life; Humans; Male | 1991 |
Magnesium sulphate versus diazepam in the management of eclampsia: a randomized controlled trial.
Topics: Apgar Score; Diazepam; Eclampsia; Female; Humans; Infant, Newborn; Infusions, Intravenous; Injection | 1990 |
Double-blind, randomized trial of diazepam versus placebo for prevention of recurrence of febrile seizures.
Topics: Administration, Oral; Child, Preschool; Diazepam; Double-Blind Method; Drug Evaluation; Female; Huma | 1990 |
Intermittent prophylaxis in febrile convulsions: diazepam or valproic acid?
Topics: Diazepam; Female; Humans; Infant; Male; Prospective Studies; Randomized Controlled Trials as Topic; | 1990 |
Diazepam treatment of early symptoms of schizophrenic relapse.
Topics: Administration, Oral; Clinical Trials as Topic; Diazepam; Female; Humans; Male; Recurrence; Schizoph | 1989 |
Relapse and rebound following discontinuation of benzodiazepine treatment of panic attacks: alprazolam versus diazepam.
Topics: Adult; Alprazolam; Anxiety; Diazepam; Double-Blind Method; Fear; Female; Humans; Male; Middle Aged; | 1989 |
Prophylactic treatment with valproic acid or diazepam in children with febrile convulsions.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Female; Humans; Infant; Male; Recurrenc | 1986 |
Frequent febrile episodes and recurrent febrile convulsions.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Prospective Studies; Random Allocation; | 1988 |
Recurrence risk after first febrile seizure and effect of short term diazepam prophylaxis.
Topics: Age Factors; Clinical Trials as Topic; Diazepam; Female; Humans; Infant; Male; Prospective Studies; | 1985 |
Effective short-term diazepam prophylaxis in febrile convulsions.
Topics: Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Male; Patient Compliance; Random Alloc | 1985 |
Clinical comparison of anxiolytic drug therapy.
Topics: Administration, Oral; Adolescent; Adult; Amobarbital; Anti-Anxiety Agents; Anxiety; Barbiturates; Ca | 1974 |
[Treatment of anxiety neuroses in general practice using Lorazepam (Tavor)].
Topics: Adolescent; Adult; Anxiety Disorders; Ataxia; Diazepam; Electroencephalography; Evaluation Studies a | 1972 |
61 other studies available for diazepam and Recrudescence
| Article | Year |
|---|---|
Efficacy, safety, and economic impact of diazepam suppositories with as-needed acetaminophen for prevention of seizure recurrence during the same fever episode in children with suspected simple febrile seizures.
Topics: Acetaminophen; Child; Diazepam; Fever; Humans; Infant; Prospective Studies; Recurrence; Seizures, Fe | 2022 |
Risk factors for acute encephalitis and early seizure recurrence in complex febrile seizures.
Topics: Child; Child, Preschool; Diazepam; Encephalitis; Humans; Infant; Recurrence; Retrospective Studies; | 2022 |
Change in the strategy for prophylactic diazepam use for febrile seizures and the impact on seizure recurrence within 24 h.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Drug Administration Routes; Female; Humans; Infant; Jap | 2020 |
Efficacy of levetiracetam versus fosphenytoin for the recurrence of seizures after status epilepticus.
Topics: Administration, Intravenous; Administration, Oral; Anticonvulsants; Blood Pressure; Databases, Factu | 2017 |
Minocycline in Alcohol Withdrawal Induced Anxiety and Alcohol Relapse in Rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Anti-Bacterial Agents; Anxiety; Diazepam; Disease Models, Ani | 2018 |
Intermittent prophylaxis of recurrent febrile seizures with clobazam versus diazepam.
Topics: Age Factors; Anticonvulsants; Ataxia; Bangladesh; Benzodiazepines; Chi-Square Distribution; Child, P | 2014 |
Lorazepam v. diazepam for pediatric status epilepticus.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Female; Humans; Infant; Lorazepam; Male; Randomized Con | 2016 |
Relapses and recurrences of catatonia: 30-case analysis and literature review.
Topics: Adolescent; Adult; Antipsychotic Agents; Bipolar Disorder; Catatonia; Clozapine; Depressive Disorder | 2016 |
High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Respons | 2010 |
Gamma-butyrolactone (GBL) dependence and withdrawal.
Topics: 4-Butyrolactone; Adult; Ambulatory Care; Baclofen; Delirium; Diazepam; Dose-Response Relationship, D | 2011 |
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
Topics: Animals; Anticonvulsants; Biomarkers; Cell Hypoxia; Cerebral Cortex; Convulsants; Diazepam; Disease | 2013 |
[A common emergency in childhood. Febrile convulsions -- what to do?].
Topics: Acetaminophen; Administration, Rectal; Age Factors; Analgesics, Non-Narcotic; Anticonvulsants; Clona | 2003 |
[Isoniazid intoxication].
Topics: Acidosis; Anticonvulsants; Antidotes; Antitubercular Agents; Diazepam; Female; Humans; Infusions, In | 2007 |
Funny turns in an elderly man.
Topics: Age Factors; Aged; Anticonvulsants; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Male; Recur | 2007 |
An adult case of cyclic vomiting syndrome successfully responding to valproic acid.
Topics: Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Consciousness Disorders; Diazepam; Female; Humans | 2008 |
[Prolonged pharmacologic sleep in the complex treatment of patients with severe forms of alcoholic delirium].
Topics: Adult; Alcohol Withdrawal Delirium; Antipsychotic Agents; Barbiturates; Diazepam; Droperidol; Drug T | 1981 |
Febrile convulsions.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Female; Fever; Humans; Infant; Male; Phenobarbital; Rec | 1983 |
[Continuous oral phenobarbital or intermittent rectal diazepam for the prevention of febrile convulsions].
Topics: Administration, Oral; Child, Preschool; Diazepam; Female; Humans; Infant; Longitudinal Studies; Male | 1984 |
[Prevention of febrile convulsions and kinetics of diazepam per os].
Topics: Child, Preschool; Diazepam; Humans; Infant; Kinetics; Recurrence; Seizures, Febrile | 1984 |
Prophylaxis and febrile convulsions.
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Se | 1981 |
Recurrence of intravenous-diazepam-induced phlebitis from oral diazepam.
Topics: Administration, Oral; Adult; Diazepam; Humans; Injections, Intravenous; Male; Recurrence; Thrombophl | 1983 |
Sphincter dyssynergia in children with reflux.
Topics: Child; Child, Preschool; Diazepam; Female; Humans; Hydronephrosis; Male; Recurrence; Ureter; Urinary | 1983 |
Coping with the negative therapeutic response in psychosocial problems in family medicine.
Topics: Adult; Dependency, Psychological; Depressive Disorder; Diazepam; Family Practice; Family Therapy; Fe | 1983 |
[Treatment of febrile convulsions. New data and new options].
Topics: Anticonvulsants; Chloral Hydrate; Diazepam; Humans; Recurrence; Seizures, Febrile | 1982 |
Intravenous clonazepam in the treatment of status epilepticus in children.
Topics: Adolescent; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Diazepam; Electroencephalography | 1980 |
[Treatment of febrile convulsions in infants].
Topics: Anticonvulsants; Diazepam; Humans; Infant; Recurrence; Seizures, Febrile; Valproic Acid | 1995 |
Non-convulsive status epilepticus.
Topics: Adolescent; Child; Child Behavior Disorders; Child, Preschool; Diazepam; Electroencephalography; Fem | 1995 |
Effect of prehospital treatment on the outcome of status epilepticus in children.
Topics: Administration, Rectal; Adolescent; Allied Health Personnel; Child; Child, Preschool; Diazepam; Dose | 1995 |
Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period.
Topics: Anticonvulsants; Diazepam; Drug Administration Schedule; Electroencephalography; Humans; Infant, Low | 1995 |
Prevention of recurrent febrile seizures.
Topics: Acetaminophen; Child; Diazepam; Humans; Recurrence; Seizures, Febrile | 1995 |
Mexiletine overdose producing status epilepticus without cardiovascular abnormalities.
Topics: Adult; Blood Pressure; Cardiovascular System; Diazepam; Drug Overdose; Drug Therapy, Combination; El | 1994 |
Short-term prophylaxis of febrile convulsions by oral diazepam.
Topics: Administration, Oral; Child, Preschool; Diazepam; Humans; Infant; Patient Compliance; Prospective St | 1993 |
Diazepam to reduce recurrences of febrile seizures.
Topics: Administration, Oral; Anticonvulsants; Child, Preschool; Diazepam; Humans; Infant; Recurrence; Seizu | 1996 |
Early clinical and EEG features of infantile spasms in Down syndrome.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Comorbidity; Diazepam; Down Syndrome; Elect | 1996 |
Suspected herbicide toxicosis in a dog.
Topics: 2-Methyl-4-chlorophenoxyacetic Acid; Abdominal Pain; Animals; Anorexia; Antidotes; Antiemetics; Atax | 1996 |
[Intermittent prophylaxis in febrile seizures with oral diazepam: study of 82 cases].
Topics: Child, Preschool; Diazepam; Female; Humans; Infant; Male; Prospective Studies; Recurrence; Respite C | 1996 |
[Efficacy of rectal diazepam suppository in the prophylaxis of febrile seizures: comparison with rectal chloral hydrate suppository].
Topics: Child; Child, Preschool; Chloral Hydrate; Diazepam; Female; Humans; Infant; Male; Recurrence; Seizur | 1997 |
Gaining a perspective on childhood seizures.
Topics: Administration, Rectal; Adult; Child; Diazepam; Epilepsy; Humans; Recurrence; Seizures, Febrile | 1998 |
Pros and cons of treatments and studies of recurrent febrile seizures.
Topics: Anticonvulsants; Child; Diazepam; Humans; Randomized Controlled Trials as Topic; Recurrence; Seizure | 1998 |
Treatment of acute repetitive seizures.
Topics: Administration, Rectal; Adult; Child; Clinical Trials as Topic; Diazepam; Epilepsy; Ethics, Medical; | 1998 |
Initial treatment of generalized convulsive status epilepticus.
Topics: Adolescent; Adult; Anticonvulsants; Diazepam; Double-Blind Method; Electroencephalography; Emergenci | 1999 |
Technical report: treatment of the child with simple febrile seizures.
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe | 1999 |
[Recurrent abnormal motion of the lower legs during the recovery from spinal anesthesia].
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; | 2000 |
[Treatment of febrile convulsions].
Topics: Age Factors; Analgesics, Non-Narcotic; Anticonvulsants; Carbamazepine; Child, Preschool; Diazepam; D | 2002 |
[Intermittent prophylaxis of febrile convulsions with diazepam].
Topics: Child, Preschool; Diazepam; Drug Evaluation; Female; Follow-Up Studies; Humans; Infant; Male; Recurr | 1979 |
Problems of childhood. Febrile fits.
Topics: Age Factors; Child, Preschool; Diazepam; Epilepsy, Tonic-Clonic; Female; Fever; Humans; Infant; Male | 1976 |
Diazepam treatment of socially isolated monkeys.
Topics: Aggression; Animals; Behavior, Animal; Diazepam; Exploratory Behavior; Female; Haplorhini; Humans; I | 1976 |
The practicality of the Congo Red test, or is your vagotomy complete?
Topics: Animals; Betazole; Congo Red; Diazepam; Dogs; Duodenal Ulcer; Gastric Mucosa; Gastroscopy; Humans; P | 1976 |
Catatonia and the neuroleptic malignant syndrome--a single entity?
Topics: Adult; Catatonia; Chlorpromazine; Diazepam; Female; Follow-Up Studies; Humans; Neuroleptic Malignant | 1992 |
Endoscopic sclerotherapy: treatment of choice in patients less than 3 years old with extrahepatic portal vein obstruction.
Topics: Child, Preschool; Constriction, Pathologic; Diazepam; Endoscopy; Feasibility Studies; Female; Follow | 1992 |
Role of lidocaine (lignocaine) in managing status epilepticus.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diazepam; Dose-Response Relationship, Drug; Evoked Poten | 1992 |
Diazepam for prevention of recurrence of febrile seizures.
Topics: Child; Diazepam; Drug Evaluation; Humans; Recurrence; Seizures, Febrile | 1991 |
EEG monitoring of therapy for neonatal seizures.
Topics: Anticonvulsants; Chloral Hydrate; Clonazepam; Diazepam; Drug Therapy, Combination; Electroencephalog | 1990 |
Neuroleptic malignant syndrome.
Topics: Adult; Diazepam; Drug Therapy, Combination; Humans; Lithium; Male; Neuroleptic Malignant Syndrome; R | 1990 |
Pharmacokinetics of rectal diazepam in the prevention of recurrent febrile convulsions.
Topics: Diazepam; Dose-Response Relationship, Drug; Humans; Infant; Kinetics; Prognosis; Rectum; Recurrence; | 1986 |
One-year follow-up of anxious patients treated with diazepam.
Topics: Adult; Anxiety Disorders; Diazepam; Female; Follow-Up Studies; Humans; Male; Psychiatric Status Rati | 1986 |
[A pharmacokinetic study on the effectiveness of intermittent oral diazepam in the prevention of recurrent febrile convulsions].
Topics: Administration, Oral; Child, Preschool; Diazepam; Humans; Infant; Recurrence; Seizures, Febrile; Sup | 1985 |
Diazepam treatment for acute convulsions in children. A report of 41 patients, three with plasma levels.
Topics: Adolescent; Age Factors; Brain Damage, Chronic; Brain Injuries; Child; Child, Preschool; Diazepam; E | 1974 |
Status epilepticus.
Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb | 1974 |
Continuous infusion of diazepam in infants with severe recurrent convulsions.
Topics: Acute Disease; Age Factors; Diazepam; Female; Humans; Hypoxia; Infant; Infant, Newborn; Injections, | 1974 |
Age-sex differences in response to antidepressant drugs.
Topics: Adjustment Disorders; Adolescent; Adult; Age Factors; Aged; Antidepressive Agents; Anxiety; Chlorpro | 1974 |