diazepam has been researched along with Pulmonary Fibrosis in 2 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazepam could regulate immune system and inflammation, which might be a potential therapeutic agent for pulmonary fibrosis in clinic." | 7.91 | Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABA ( Bo, F; Deng, M; Li, Y; Song, D; Tang, X, 2019) |
| "Diazepam could regulate immune system and inflammation, which might be a potential therapeutic agent for pulmonary fibrosis in clinic." | 3.91 | Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABA ( Bo, F; Deng, M; Li, Y; Song, D; Tang, X, 2019) |
| " This study demonstrates that although diazepam is well absorbed when administered endotracheally, it has adverse effects on the lungs that may preclude endotracheal use in the currently available commercial form." | 1.27 | Endotracheal diazepam: absorption and pulmonary pathologic effects. ( Aaron, CK; Bonner, H; Lathers, CM; McNamara, RM; Rusli, M; Spivey, WH, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Song, D | 1 |
| Bo, F | 1 |
| Deng, M | 1 |
| Tang, X | 1 |
| Rusli, M | 1 |
| Spivey, WH | 1 |
| Bonner, H | 1 |
| McNamara, RM | 1 |
| Aaron, CK | 1 |
| Lathers, CM | 1 |
2 other studies available for diazepam and Pulmonary Fibrosis
| Article | Year |
|---|---|
Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABA
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Diazepam; Disease Models, Animal; Humans; Inf | 2019 |
Endotracheal diazepam: absorption and pulmonary pathologic effects.
Topics: Absorption; Animals; Cats; Diazepam; Intubation, Intratracheal; Lung; Pulmonary Fibrosis | 1987 |