diazepam has been researched along with Parkinson Disease in 22 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 59-year-old man, who was diagnosed as having Parkinson's disease and depression seven years ago and was on oral antiparkinsonian agents, antianxiety agents, and antidepressants, developed a high fever, disturbed consciousness, and marked muscle rigidity after discontinuation of etizolam and amitriptyline." | 7.71 | [A patient with Parkinson's disease complicated by hypothyroidism who developed malignant syndrome after discontinuation of etizolam]. ( Araki, T; Esaki, S; Furuya, H; Inoue, N; Kawajiri, M; Kira, J; Ohyagi, Y; Yamada, T, 2002) |
| "A 59-year-old man, who was diagnosed as having Parkinson's disease and depression seven years ago and was on oral antiparkinsonian agents, antianxiety agents, and antidepressants, developed a high fever, disturbed consciousness, and marked muscle rigidity after discontinuation of etizolam and amitriptyline." | 3.71 | [A patient with Parkinson's disease complicated by hypothyroidism who developed malignant syndrome after discontinuation of etizolam]. ( Araki, T; Esaki, S; Furuya, H; Inoue, N; Kawajiri, M; Kira, J; Ohyagi, Y; Yamada, T, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (68.18) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 3 (13.64) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Kan, HL | 1 |
| Tung, CW | 1 |
| Chang, SE | 1 |
| Lin, YC | 1 |
| Kawajiri, M | 1 |
| Ohyagi, Y | 1 |
| Furuya, H | 1 |
| Araki, T | 1 |
| Inoue, N | 1 |
| Esaki, S | 1 |
| Yamada, T | 1 |
| Kira, J | 1 |
| Meagher, LJ | 1 |
| McKay, D | 1 |
| Herkes, GK | 1 |
| Needham, M | 1 |
| Alonso-Navarro, H | 1 |
| Jiménez-Jiménez, FJ | 1 |
| Strang, RR | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Isozaki, E | 1 |
| Hayashi, M | 1 |
| Hayashida, T | 1 |
| Tanabe, H | 1 |
| Hirai, S | 1 |
| Baumann, P | 1 |
| Cohen, CI | 1 |
| Mets, B | 1 |
| Frankel, JP | 1 |
| Hughes, A | 1 |
| Lees, AJ | 1 |
| Stern, GM | 1 |
| Pourcher, E | 1 |
| Bonnet, AM | 1 |
| Kefalos, J | 1 |
| Dubois, B | 1 |
| Agid, Y | 1 |
| Stern, J | 1 |
| Mendell, J | 1 |
| Clark, K | 1 |
| Papeschi, R | 1 |
| Molina-Negro, P | 1 |
| Sourkes, TL | 1 |
| Erba, G | 1 |
| Sigwald, J | 1 |
| Rondot, P | 1 |
| Raverdy, P | 1 |
| Singer, B | 1 |
| Lavy, S | 1 |
| Marks, ES | 1 |
| Abramsky, O | 1 |
| Markham, CH | 1 |
| Wodak, J | 1 |
| Gilligan, BS | 1 |
| Veale, JL | 1 |
| Dowty, BJ | 1 |
| Tyler, HR | 1 |
| Knopp, W | 1 |
| Diemath, HE | 1 |
| Enge, S | 1 |
| Lechner, H | 1 |
| Nathan, PW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Diagnostic Accuracy of Non-Contrast Computed Tomography in Correlation With Ultrasound in Detecting Acute Appendicitis in Adults[NCT05815446] | 78 participants (Anticipated) | Observational | 2023-04-20 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diazepam and Parkinson Disease
| Article | Year |
|---|---|
[ECT: The apple of discord in modern psychiatry (author's transl)].
Topics: Aggression; Anxiety; Atropine; Biogenic Amines; Confusion; Cyclic AMP; Depression; Diazepam; Electro | 1979 |
Advances in neurology.
Topics: Analgesics; Anticoagulants; Brain; Brain Neoplasms; Carbamazepine; Cerebrovascular Disorders; Contra | 1968 |
1 trial available for diazepam and Parkinson Disease
| Article | Year |
|---|---|
Psychiatric changes in patients treated with levodopa. I. The clinical experiment.
Topics: Activities of Daily Living; Adjustment Disorders; Aged; Amitriptyline; Clinical Trials as Topic; Dia | 1970 |
19 other studies available for diazepam and Parkinson Disease
| Article | Year |
|---|---|
In silico prediction of parkinsonian motor deficits-related neurotoxicants based on the adverse outcome pathway concept.
Topics: Adverse Outcome Pathways; Animals; Diazepam; Electron Transport Complex I; Molecular Docking Simulat | 2022 |
[A patient with Parkinson's disease complicated by hypothyroidism who developed malignant syndrome after discontinuation of etizolam].
Topics: Antidepressive Agents; Depression; Diazepam; Humans; Hypothyroidism; Male; Middle Aged; Neuroleptic | 2002 |
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Ba | 2006 |
Panic attack like episodes possibly associated with pramipexole therapy in Parkinson's disease.
Topics: Anxiety Disorders; Benzothiazoles; Carbidopa; Central Nervous System; Diazepam; Dopamine Agonists; D | 2007 |
The symptom of restless legs.
Topics: Adult; Aged; Anemia, Hypochromic; Chlordiazepoxide; Diazepam; Female; Humans; Iron; Leg; Male; Middl | 1967 |
[Systems relations in neuropathology and psychiatry (various problems in treatment)].
Topics: Central Nervous System; Chorea; Diazepam; Epilepsy; Humans; Mental Disorders; Nervous System Disease | 1981 |
[Vocal cord abductor paralysis in multiple system atrophy--paradoxical movement of vocal cords during sleep].
Topics: Aged; Diazepam; Female; Fiber Optic Technology; Humans; Laryngoscopy; Male; Middle Aged; Movement; O | 1996 |
A case report: periodontal surgery in Parkinsonism utilizing intravenous sedation.
Topics: Aged; Anesthesia, Dental; Diazepam; Female; Humans; Injections, Intravenous; Parkinson Disease; Peri | 1978 |
Acute dystonia after alfentanil in untreated Parkinson's disease.
Topics: Aged; Alfentanil; Diazepam; Dystonia; Female; Humans; Parkinson Disease; Preanesthetic Medication | 1991 |
Marijuana for parkinsonian tremor.
Topics: Antiparkinson Agents; Apomorphine; Carbidopa; Diazepam; Drug Combinations; Humans; Levodopa; Marijua | 1990 |
Effects of etybenzatropine and diazepam on levodopa-induced diphasic dyskinesias in Parkinson's disease.
Topics: Diazepam; Humans; Levodopa; Middle Aged; Movement Disorders; Parkinson Disease; Pilot Projects; Trop | 1989 |
H reflex suppression by thalamic stimulation and drug administration.
Topics: Chlorpromazine; Diazepam; Electric Stimulation; Humans; Motor Neurons; Muscle Spindles; Oscillometry | 1968 |
The concentration of homovanillic and 5-hydroxyindoleacetic acids in ventricular and lumbar CSF. Studies in patients with extrapyramidal disorders, epilepsy, and other diseases.
Topics: Adolescent; Adult; Basal Ganglia Diseases; Cerebral Palsy; Cerebral Ventricles; Diazepam; Dihydroxyp | 1972 |
[Stiff man syndrome. Clinical, electrologic and therapeutic details].
Topics: Curare; Diagnosis, Differential; Diazepam; Electromyography; Emotions; Fatigue; Female; Humans; Midd | 1968 |
Parkinsonism and hyperthyroidism.
Topics: Diazepam; Dihydroxyphenylalanine; Drug Therapy, Combination; Female; Humans; Hyperthyroidism; Male; | 1974 |
The "on-off" side effect of L-DOPA.
Topics: Age Factors; Amitriptyline; Aromatic Amino Acid Decarboxylase Inhibitors; Athetosis; Carbidopa; Cate | 1974 |
Review of 12 months' treatment with L-dopa in Parkinson's disease, with remarks on unusual side effects.
Topics: Adult; Aged; Atrial Flutter; Body Weight; Deglutition Disorders; Diazepam; Dihydroxyphenylalanine; D | 1972 |
EEG depth leads during stereotaxic brain surgery. A report on 117 cases (5 target points, effects of 13 different drugs).
Topics: Amides; Amygdala; Antimetabolites; Asparagine; Benzoates; Brain; Brain Diseases; Cerebrovascular Cir | 1970 |
The action of diazepam in neurological disorders with excessive motor activity.
Topics: Brain Diseases; Decerebrate State; Diazepam; Diencephalon; Electromyography; Epilepsy; Hemiplegia; H | 1970 |