diazepam has been researched along with Panic Disorder in 27 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Panic Disorder: A type of anxiety disorder characterized by unexpected panic attacks that last minutes or, rarely, hours. Panic attacks begin with intense apprehension, fear or terror and, often, a feeling of impending doom. Symptoms experienced during a panic attack include dyspnea or sensations of being smothered; dizziness, loss of balance or faintness; choking sensations; palpitations or accelerated heart rate; shakiness; sweating; nausea or other form of abdominal distress; depersonalization or derealization; paresthesias; hot flashes or chills; chest discomfort or pain; fear of dying and fear of not being in control of oneself or going crazy. Agoraphobia may also develop. Similar to other anxiety disorders, it may be inherited as an autosomal dominant trait.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alprazolam has proven efficacy as a treatment for panic disorder, but the place of other benzodiazepines is less well established." | 9.08 | Diazepam versus alprazolam for the treatment of panic disorder. ( Burrows, GD; Cook, BL; Garvey, MJ; Judd, FK; Marriott, P; Norman, TR; Noyes, R; Reich, JH, 1996) |
| "A double-blind, placebo-controlled trial was undertaken to compare the effects of imipramine and clomipramine in the treatment of panic disorder with or without agoraphobia." | 9.07 | Superiority of clomipramine over imipramine in the treatment of panic disorder: a placebo-controlled trial. ( Eriksson, E; Modigh, K; Westberg, P, 1992) |
| "The aim of the current study was to determine the degree to which patients with panic disorder develop tolerance to subjective and physiological effects of benzodiazepine after chronic treatment with alprazolam." | 7.69 | Benzodiazepine sensitivity in panic disorder: effects of chronic alprazolam treatment. ( Cowley, DS; Greenblatt, DJ; Hommer, DW; Nemeroff, CB; Radant, A; Ritchie, JC; Roy-Byrne, PP, 1995) |
| "Alprazolam has proven efficacy as a treatment for panic disorder, but the place of other benzodiazepines is less well established." | 5.08 | Diazepam versus alprazolam for the treatment of panic disorder. ( Burrows, GD; Cook, BL; Garvey, MJ; Judd, FK; Marriott, P; Norman, TR; Noyes, R; Reich, JH, 1996) |
| "The effects of four increasing intravenous doses of diazepam on saccadic eye movement velocity and accuracy (the latter being a saccadic variable that is unaffected by sedation), short-term memory, and self- and observer-rated sedation were assessed in 18 patients with panic disorder, 15 patients with obsessive-compulsive disorder, and 14 normal comparison subjects." | 5.08 | Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects. ( Cowley, DS; Greenblatt, DJ; Radant, A; Roy-Byrne, P; Wingerson, DK, 1996) |
| "The effects of four logarithmically increasing doses of intravenous diazepam or placebo on plasma homovanillic acid (HVA) were determined in benzodiazepine-naive patients with panic disorder (PD) or generalized anxiety disorder (GAD), and in healthy controls." | 5.08 | Effect of benzodiazepines on plasma levels of homovanillic acid in anxious patients and control subjects. ( Cowley, DS; Kramer, GL; Petty, F; Roy-Byrne, PP; Wingerson, DK, 1996) |
| "To examine the effect of treatment on lactate-induced anxiety in a controlled study, we infused 44 panic disorder patients with lactate and placebo before and after eight weeks of double-blind treatment with imipramine, diazepam, or placebo." | 5.07 | Lactate-induced anxiety after imipramine and diazepam treatment. ( Balon, R; Berchou, R; Lycaki, H; Pohl, R, 1994) |
| "The acute effects of diazepam on plasma GABA were determined in 18 patients with panic disorder, 13 patients with generalized anxiety disorder and 20 healthy controls." | 5.07 | Effect of acute and chronic benzodiazepines on plasma GABA in anxious patients and controls. ( Cowley, DS; Greenblatt, DJ; Hommer, D; Kramer, GL; Petty, F; Roy-Byrne, PP, 1992) |
| "A double-blind, placebo-controlled trial was undertaken to compare the effects of imipramine and clomipramine in the treatment of panic disorder with or without agoraphobia." | 5.07 | Superiority of clomipramine over imipramine in the treatment of panic disorder: a placebo-controlled trial. ( Eriksson, E; Modigh, K; Westberg, P, 1992) |
| " Because imipramine has lowered T4 in uncontrolled studies we examined the effect of imipramine on serum thyroid levels in panic disorder patients in a double-blind placebo and diazepam treatment controlled study." | 5.07 | The changes of thyroid hormone during pharmacological treatment of panic disorder patients. ( Balon, R; Glitz, DA; Pohl, R; Ramesh, C; Yeragani, VK, 1991) |
| "The aim of the current study was to determine the degree to which patients with panic disorder develop tolerance to subjective and physiological effects of benzodiazepine after chronic treatment with alprazolam." | 3.69 | Benzodiazepine sensitivity in panic disorder: effects of chronic alprazolam treatment. ( Cowley, DS; Greenblatt, DJ; Hommer, DW; Nemeroff, CB; Radant, A; Ritchie, JC; Roy-Byrne, PP, 1995) |
| "Adult rats submitted to a protein deprivation schedule at perinatal age (from 14th day of fetal life until 50 days of age) and then recovered on balanced chow (D rats) were assayed in the elevated plus-maze test for anticonflict effects of diazepam and drugs with therapeutic efficacy in panic disorders as compared with controls (C rats)." | 3.68 | Perinatally protein-deprived rats and reactivity to anxiolytic drugs in the plus-maze test: an animal model for screening antipanic agents? ( Cordoba, NE; Laino, CH; Orsingher, OA, 1993) |
| " Self-ratings of avoidance and distress, frequency of panic attacks, diazepam use, and negative cognitions decreased with treatment." | 3.68 | Cognitive-behavioral treatment for panic disorder with gastrointestinal symptoms: a case study. ( Eldridge, GD; Holborn, SW; Walker, JR, 1993) |
| " Eighteen patients with panic disorder, 12 patients with generalized anxiety disorder, and 21 control subjects underwent both personality testing and assessment of their sensitivity to diazepam, as measured by slowing of saccadic eye movement velocity." | 3.68 | Personality and benzodiazepine sensitivity in anxious patients and control subjects. ( Cowley, DS; Greenblatt, DJ; Hommer, DW; Roy-Byrne, PP, 1993) |
| "Alprazolam and diazepam were associated with a lower dropout rate compared to placebo and were ranked as the most tolerated of all the medications examined." | 3.01 | Pharmacological treatments in panic disorder in adults: a network meta-analysis. ( Barbui, C; Bighelli, I; Caldwell, DM; Cipriani, A; Davies, SJ; Dawson, S; Dias, S; Furukawa, TA; Guaiana, G; Imai, H; Koesters, M; Meader, N; Pompoli, A; Robertson, L; Tajika, A, 2023) |
| "The diazepam pretreatment condition was associated with a significantly increased infusion duration and a significant attenuation of rate of API symptom increase in response to lactate." | 2.68 | Effects of intravenous diazepam pretreatment on lactate-induced panic. ( Campeas, RB; Coplan, JD; Davies, SO; Dillon, DJ; Fyer, AJ; Gorman, JM; Klein, DF; Liebowitz, MR; Martinez, J, 1995) |
| "The greatest problem with combined treatment is relapse after drug discontinuance." | 2.40 | Benzodiazepines and exposure-based cognitive behavior therapies for panic disorder: conclusions from combined treatment trials. ( Bruce, TJ; Spiegel, DA, 1997) |
| "Early identification and treatment of panic disorder might help to avoid unnecessary repeated emergency department visits, and at the same time reduce the associated high risk of suicide and other psychiatric disorders such as depression as well as drug and alcohol abuse." | 2.38 | [Emergency: the internist as psychiatrist]. ( Knüsel, H, 1993) |
| " However, although the NPS anxiolytic dose-response curve displayed the classical sigmoidal shape, the dose-response curve of the putative panicolytic-like effect was bell shaped with peak effect at 0." | 1.38 | Anxiolytic- and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze. ( Calo, G; Guerrini, R; Pulga, A; Rizzi, A; Ruzza, C, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (77.78) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Guaiana, G | 1 |
| Meader, N | 1 |
| Barbui, C | 1 |
| Davies, SJ | 1 |
| Furukawa, TA | 1 |
| Imai, H | 1 |
| Dias, S | 1 |
| Caldwell, DM | 1 |
| Koesters, M | 1 |
| Tajika, A | 1 |
| Bighelli, I | 1 |
| Pompoli, A | 1 |
| Cipriani, A | 1 |
| Dawson, S | 1 |
| Robertson, L | 1 |
| Klein, S | 1 |
| Nicolas, LB | 1 |
| Lopez-Lopez, C | 1 |
| Jacobson, LH | 1 |
| McArthur, SG | 1 |
| Grundschober, C | 1 |
| Prinssen, EP | 1 |
| Pulga, A | 1 |
| Ruzza, C | 1 |
| Rizzi, A | 1 |
| Guerrini, R | 1 |
| Calo, G | 1 |
| Delmont, E | 1 |
| Bourg, V | 1 |
| Thomas, P | 1 |
| Gruber, EN | 1 |
| Dordević, V | 1 |
| Biocina-Martić, S | 1 |
| Agius, M | 1 |
| Alonso-Navarro, H | 1 |
| Jiménez-Jiménez, FJ | 1 |
| Cohen, SI | 1 |
| Cowley, DS | 5 |
| Roy-Byrne, PP | 4 |
| Radant, A | 2 |
| Ritchie, JC | 1 |
| Greenblatt, DJ | 4 |
| Nemeroff, CB | 1 |
| Hommer, DW | 2 |
| Laino, CH | 1 |
| Cordoba, NE | 1 |
| Orsingher, OA | 1 |
| Eldridge, GD | 1 |
| Walker, JR | 1 |
| Holborn, SW | 1 |
| Tyrer, P | 2 |
| Seivewright, N | 2 |
| Ferguson, B | 2 |
| Murphy, S | 1 |
| Johnson, AL | 1 |
| Balon, R | 3 |
| Yeragani, VK | 2 |
| Pohl, R | 3 |
| Merlos, B | 1 |
| Sherwood, P | 1 |
| Knüsel, H | 1 |
| Liebowitz, MR | 1 |
| Coplan, JD | 1 |
| Martinez, J | 1 |
| Fyer, AJ | 1 |
| Dillon, DJ | 1 |
| Campeas, RB | 1 |
| Davies, SO | 1 |
| Gorman, JM | 1 |
| Klein, DF | 1 |
| Noyes, R | 1 |
| Burrows, GD | 1 |
| Reich, JH | 1 |
| Judd, FK | 1 |
| Garvey, MJ | 1 |
| Norman, TR | 1 |
| Cook, BL | 1 |
| Marriott, P | 1 |
| Roy-Byrne, P | 1 |
| Wingerson, DK | 2 |
| Kramer, GL | 2 |
| Petty, F | 2 |
| Berchou, R | 1 |
| Lycaki, H | 1 |
| Spiegel, DA | 1 |
| Bruce, TJ | 1 |
| Pollack, MH | 1 |
| Matthews, J | 1 |
| Scott, EL | 1 |
| Bernik, MA | 1 |
| Gorenstein, C | 1 |
| Vieira Filho, AH | 1 |
| Hommer, D | 1 |
| Modigh, K | 1 |
| Westberg, P | 1 |
| Eriksson, E | 1 |
| Tyrer, J | 1 |
| McElroy, SL | 1 |
| Keck, PE | 1 |
| Lawrence, JM | 1 |
| Ramesh, C | 1 |
| Glitz, DA | 1 |
3 reviews available for diazepam and Panic Disorder
| Article | Year |
|---|---|
Pharmacological treatments in panic disorder in adults: a network meta-analysis.
Topics: Adult; Alprazolam; Antidepressive Agents; Antidepressive Agents, Tricyclic; Benzodiazepines; Clomipr | 2023 |
[Emergency: the internist as psychiatrist].
Topics: Crisis Intervention; Depressive Disorder; Diagnosis, Differential; Diazepam; Emergencies; Family Pra | 1993 |
Benzodiazepines and exposure-based cognitive behavior therapies for panic disorder: conclusions from combined treatment trials.
Topics: Agoraphobia; Animals; Benzodiazepines; Clinical Trials as Topic; Cognitive Behavioral Therapy; Combi | 1997 |
12 trials available for diazepam and Panic Disorder
| Article | Year |
|---|---|
The Nottingham study of neurotic disorder. Effect of personality status on response to drug treatment, cognitive therapy and self-help over two years.
Topics: Adult; Anxiety Disorders; Cognitive Behavioral Therapy; Depressive Disorder; Diazepam; Dothiepin; Fe | 1993 |
Changes in appetite and weight during the pharmacological treatment of patients with panic disorder.
Topics: Adult; Agoraphobia; Appetite; Body Weight; Diazepam; Dietary Carbohydrates; Double-Blind Method; Fem | 1993 |
Effects of intravenous diazepam pretreatment on lactate-induced panic.
Topics: Adult; Agoraphobia; Anti-Anxiety Agents; Arousal; Blood Pressure; Diazepam; Fear; Female; Heart Rate | 1995 |
Diazepam versus alprazolam for the treatment of panic disorder.
Topics: Adult; Age of Onset; Alprazolam; Diazepam; Double-Blind Method; Drug Administration Schedule; Female | 1996 |
Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects.
Topics: Adult; Anti-Anxiety Agents; Arousal; Diazepam; Double-Blind Method; Female; Humans; Male; Memory, Sh | 1996 |
Effect of benzodiazepines on plasma levels of homovanillic acid in anxious patients and control subjects.
Topics: Adult; Anxiety Disorders; Benzodiazepines; Diazepam; Dopamine; Female; Homovanillic Acid; Humans; Ma | 1996 |
Lactate-induced anxiety after imipramine and diazepam treatment.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety Disorders; Arousal | 1994 |
Stressful reactions and panic attacks induced by flumazenil in chronic benzodiazepine users.
Topics: Adult; Anti-Anxiety Agents; Arousal; Diazepam; Double-Blind Method; Female; Flumazenil; GABA Modulat | 1998 |
Effect of acute and chronic benzodiazepines on plasma GABA in anxious patients and controls.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Anxiety Disorders; Diazepam; gamma-Aminobutyric Acid; Humans | 1992 |
Superiority of clomipramine over imipramine in the treatment of panic disorder: a placebo-controlled trial.
Topics: Adult; Clomipramine; Diazepam; Double-Blind Method; Female; Humans; Imipramine; Male; Panic Disorder | 1992 |
The general neurotic syndrome: a coaxial diagnosis of anxiety, depression and personality disorder.
Topics: Adjustment Disorders; Anxiety Disorders; Cognitive Behavioral Therapy; Depressive Disorder; Diazepam | 1992 |
The changes of thyroid hormone during pharmacological treatment of panic disorder patients.
Topics: Adult; Analysis of Variance; Anxiety; Chi-Square Distribution; Diazepam; Double-Blind Method; Female | 1991 |
12 other studies available for diazepam and Panic Disorder
| Article | Year |
|---|---|
Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Body Temperature; Diazepam; Disease Models, Animal; Escape R | 2010 |
Anxiolytic- and panicolytic-like effects of Neuropeptide S in the mouse elevated T-maze.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiety; Diazepam; Dose-Resp | 2012 |
[Epileptic Münchausen syndrome by idiosyncratic of effect antiepileptic drugs].
Topics: Adult; Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Female; Headache; Humans; Muncha | 2003 |
"My new Alfa Romeo GT is not in the garage any more": Cognitive behavioural therapy of panic disorder with agoraphobia co morbid with psychosis.
Topics: Adult; Agoraphobia; Antipsychotic Agents; Atenolol; Benzodiazepines; Cognitive Behavioral Therapy; C | 2006 |
Panic attack like episodes possibly associated with pramipexole therapy in Parkinson's disease.
Topics: Anxiety Disorders; Benzothiazoles; Carbidopa; Central Nervous System; Diazepam; Dopamine Agonists; D | 2007 |
Alcohol and benzodiazepines generate anxiety, panic and phobias.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Anti-Anxiety Agents; Anxiety Disorders; Diazepam; Female; | 1995 |
Benzodiazepine sensitivity in panic disorder: effects of chronic alprazolam treatment.
Topics: Adult; Alprazolam; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Female; Growth Hormon | 1995 |
Perinatally protein-deprived rats and reactivity to anxiolytic drugs in the plus-maze test: an animal model for screening antipanic agents?
Topics: Animals; Anti-Anxiety Agents; Anxiety; Conflict, Psychological; Diazepam; Disease Models, Animal; Do | 1993 |
Cognitive-behavioral treatment for panic disorder with gastrointestinal symptoms: a case study.
Topics: Adult; Agoraphobia; Behavior Therapy; Diazepam; Fecal Incontinence; Female; Humans; Panic Disorder | 1993 |
Personality and benzodiazepine sensitivity in anxious patients and control subjects.
Topics: Adult; Anxiety Disorders; Benzodiazepines; Diazepam; Female; Humans; Male; Models, Psychological; Pa | 1993 |
Gabapentin as a potential treatment for anxiety disorders.
Topics: Acetates; Adult; Alprazolam; Amines; Anticonvulsants; Anxiety Disorders; Cyclohexanecarboxylic Acids | 1998 |
Treatment of panic disorder and benzodiazepine withdrawal with valproate.
Topics: Adult; Agoraphobia; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Humans; Male; Panic Diso | 1991 |