diazepam has been researched along with Organophosphorus Poisoning in 19 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations." | 5.40 | Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Deshpande, LS; Phillips, KF, 2014) |
| "Two cases of organophosphorus poisoning are reported." | 5.28 | Use of glycopyrrolate and atropine in acute organophosphorus poisoning. ( Gallagher, H; Tracey, JA, 1990) |
| " When the supporting drug treatment consisted of pyridostigmine pretreatment and therapy with atropine and diazepam (this treatment itself gave considerable protection against organophosphate poisoning) both the non-oxime and oxime derivatives increased the protection against all four agents although obidoxime and TMB-4 were not beneficial against soman poisoning." | 3.66 | The efficacy of bispyridinium derivatives in the treatment of organophosphonate poisoning in the guinea-pig. ( Inns, RH; Leadbeater, L, 1983) |
| "Treatment with atropine, which relieves the muscarinic effects of acetylcholine and anticonvulsive agents (diazepam) is well established." | 2.42 | [Use of oximes in the therapy of acute intoxication by organophosphorus compounds]. ( Filip, R; Raszewski, G, 2004) |
| "Memantine pretreatment (18 mg/kg sc) produced in rats poisoned with soman significantly better protective ratios (PRs) than the two carbamates - 1." | 1.51 | Prophylactic potential of memantine against soman poisoning in rats. ( Bokonjić, D; Jokanović, M; Kilibarda, V; Škrbić, R; Stojiljković, MP; Vulović, M, 2019) |
| "Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations." | 1.40 | Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Deshpande, LS; Phillips, KF, 2014) |
| "A pretreatment with diazepam for three days further increased the protection." | 1.28 | On the use of diazepam and pro-diazepam (2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig. ( Karlsson, B; Lindgren, B; Millquist, E; Sandberg, M; Sellström, A, 1990) |
| "Two cases of organophosphorus poisoning are reported." | 1.28 | Use of glycopyrrolate and atropine in acute organophosphorus poisoning. ( Gallagher, H; Tracey, JA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (26.32) | 18.7374 |
| 1990's | 5 (26.32) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vanova, N | 1 |
| Pejchal, J | 1 |
| Herman, D | 1 |
| Dlabkova, A | 1 |
| Jun, D | 2 |
| Kuruba, R | 1 |
| Wu, X | 1 |
| Reddy, DS | 1 |
| Stojiljković, MP | 1 |
| Škrbić, R | 1 |
| Jokanović, M | 1 |
| Bokonjić, D | 1 |
| Kilibarda, V | 1 |
| Vulović, M | 1 |
| Deshpande, LS | 2 |
| Carter, DS | 1 |
| Phillips, KF | 1 |
| Blair, RE | 1 |
| DeLorenzo, RJ | 2 |
| Phillips, K | 1 |
| Huang, B | 1 |
| Mumford, H | 1 |
| Docx, CJ | 1 |
| Price, ME | 1 |
| Green, AC | 1 |
| Tattersall, JE | 1 |
| Armstrong, SJ | 1 |
| Raszewski, G | 1 |
| Filip, R | 1 |
| Bajgar, J | 1 |
| Kuca, K | 1 |
| Bartosova, L | 1 |
| Fusek, J | 1 |
| Inns, RH | 2 |
| Leadbeater, L | 2 |
| Bosković, B | 1 |
| Kovacević, V | 1 |
| Jovanović, D | 1 |
| Hapke, HJ | 1 |
| Koplovitz, I | 1 |
| Stewart, JR | 1 |
| Clair, P | 1 |
| Wiberg, K | 1 |
| Granelli, I | 1 |
| Carlsson Bratt, I | 1 |
| Blanchet, G | 2 |
| Johnson, DD | 1 |
| Wilcox, WC | 1 |
| Capacio, BR | 1 |
| Harris, LW | 1 |
| Anderson, DR | 1 |
| Lennox, WJ | 1 |
| Gales, V | 1 |
| Dawson, JS | 1 |
| Karlsson, B | 1 |
| Lindgren, B | 1 |
| Millquist, E | 1 |
| Sandberg, M | 1 |
| Sellström, A | 1 |
| Tracey, JA | 1 |
| Gallagher, H | 1 |
| Bataillard, A | 1 |
| Sannajust, F | 1 |
| Yoccoz, D | 1 |
| Sentenac-Roumanou, H | 1 |
| Sassard, J | 1 |
| Rylands, JM | 1 |
2 reviews available for diazepam and Organophosphorus Poisoning
| Article | Year |
|---|---|
Oxidative stress in organophosphate poisoning: role of standard antidotal therapy.
Topics: Animals; Antidotes; Antioxidants; Atropine; Cholinesterase Reactivators; Diazepam; Humans; Organopho | 2018 |
[Use of oximes in the therapy of acute intoxication by organophosphorus compounds].
Topics: Anticonvulsants; Atropine; Cholinesterase Inhibitors; Cholinesterase Reactivators; Diazepam; Humans; | 2004 |
17 other studies available for diazepam and Organophosphorus Poisoning
| Article | Year |
|---|---|
Benzodiazepine-refractory status epilepticus, neuroinflammation, and interneuron neurodegeneration after acute organophosphate intoxication.
Topics: Animals; Antidotes; Brain; Diazepam; Disease Models, Animal; Humans; Interneurons; Male; Nerve Agent | 2018 |
Prophylactic potential of memantine against soman poisoning in rats.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Behavior, Animal; Chemical Warfare Agents; Choli | 2019 |
Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication.
Topics: Animals; Anticonvulsants; Atropine; Brain; Calcium; Diazepam; Disease Models, Animal; Electroencepha | 2014 |
Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity.
Topics: Anhedonia; Animals; Anxiety; Atropine; Behavior, Animal; Cognition Disorders; Depression; Diazepam; | 2014 |
Human plasma-derived BuChE as a stoichiometric bioscavenger for treatment of nerve agent poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Butyrylcholinesterase; Chemical Warfare Agents; | 2013 |
Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents.
Topics: Acetylcholine; Antidotes; Blood-Brain Barrier; Cholinesterase Reactivators; Cholinesterases; Diazepa | 2007 |
The efficacy of bispyridinium derivatives in the treatment of organophosphonate poisoning in the guinea-pig.
Topics: Animals; Atropine; Diazepam; Female; Guinea Pigs; Obidoxime Chloride; Organophosphate Poisoning; Pyr | 1983 |
PAM-2 Cl, HI-6, and HGG-12 in soman and tabun poisoning.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Cholinesterase Reacti | 1984 |
[Treatment of intoxications with organophosphates (author's transl)].
Topics: Animal Diseases; Animals; Atropine; Diazepam; Drug Therapy, Combination; Insecticides; Obidoxime Chl | 1980 |
A comparison of the efficacy of HI6 and 2-PAM against soman, tabun, sarin, and VX in the rabbit.
Topics: Animals; Antidotes; Atropine; Chemical Warfare Agents; Cholinesterase Inhibitors; Cholinesterase Rea | 1994 |
Stability study of a new antidote drug combination (Atropine-HI-6-Prodiazepam) for treatment of organophosphate poisoning.
Topics: Antidotes; Atropine; Cholinergic Antagonists; Cholinesterase Reactivators; Chromatography, High Pres | 2000 |
Studies on the mechanism of the protective and antidotal actions of diazepam in organophosphate poisoning.
Topics: Animals; Antidotes; Atropine; Blood Pressure; Depression, Chemical; Diazepam; Drug Interactions; Hea | 1975 |
Use of the accelerating rotarod for assessment of motor performance decrement induced by potential anticonvulsant compounds in nerve agent poisoning.
Topics: Acetazolamide; Amitriptyline; Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Cholinest | 1992 |
On the use of diazepam and pro-diazepam (2-benzoyl-4-chloro-N-methyl-N-lysylglycin anilide), as adjunct antidotes in the treatment of organophosphorus intoxication in the guinea-pig.
Topics: Animals; Antidotes; Chromatography, Gas; Diazepam; Dipeptides; Guinea Pigs; Injections, Intraperiton | 1990 |
Use of glycopyrrolate and atropine in acute organophosphorus poisoning.
Topics: Adult; Atropine; Diazepam; Drug Therapy, Combination; Glycopyrrolate; Humans; Insecticides; Male; Mi | 1990 |
Cardiovascular consequences of organophosphorus poisoning and of antidotes in conscious unrestrained rats.
Topics: Animals; Anti-Anxiety Agents; Antidotes; Atropine; Benzodiazepines; Benzodiazepinones; Blood Pressur | 1990 |
Treatment of poisoning by soman.
Topics: Animals; Antidotes; Atropine; Carbamates; Diazepam; Guinea Pigs; Male; Motor Activity; Organophospha | 1985 |