diazepam has been researched along with Obsessive-Compulsive Disorder in 40 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Obsessive-Compulsive Disorder: An anxiety disorder characterized by recurrent, persistent obsessions or compulsions. Obsessions are the intrusive ideas, thoughts, or images that are experienced as senseless or repugnant. Compulsions are repetitive and seemingly purposeful behavior which the individual generally recognizes as senseless and from which the individual does not derive pleasure although it may provide a release from tension.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The doses of modulators were selected on the basis of dose-response studies." | 5.39 | Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam. ( Bhutada, P; Deshmukh, P; Dixit, P; Kaulaskar, S; Thakur, K, 2013) |
| "The effects of four increasing intravenous doses of diazepam on saccadic eye movement velocity and accuracy (the latter being a saccadic variable that is unaffected by sedation), short-term memory, and self- and observer-rated sedation were assessed in 18 patients with panic disorder, 15 patients with obsessive-compulsive disorder, and 14 normal comparison subjects." | 5.08 | Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects. ( Cowley, DS; Greenblatt, DJ; Radant, A; Roy-Byrne, P; Wingerson, DK, 1996) |
| "Obsessions and anxiety correlated strongly for all four experimental conditions in which the sequence of the symptom provocation and diazepam i." | 5.08 | Phenomenological and pharmacological study of provoked obsessive/anxiety symptoms in obsessive-compulsive disorder: a preliminary study. ( Dysken, MW; Faris, PL; Hartman, BK; Hoover, KM; Kim, SW; Klein, KW; Kushner, MG; Kuskowski, MA, 1997) |
| "A double blind between-groups trial was carried out to compare the effectiveness of the new benzodiazepine compound, bromazepam, (Lexotan, Ro 5-3350) as an anti-anxiety compound with that of diazepan." | 5.04 | Bromazepam versus diazepam in psychoneurotic inpatients. ( Carrara, S; Cassano, GB; Castrogiovanni, P, 1975) |
| "Isocarboxazid was replaced by placebo, using double-blind procedure." | 2.67 | Efficacy of combined antidepressant therapy in resistant neurotic disorder. ( Murphy, S; Tyrer, P, 1990) |
| "Patients were assessed for phobias, obsessions, general psychiatric symptoms and side-effects and each was rated on a special symptom inventory at 0, 2, 4 and 6 weeks of treatment." | 2.64 | A clinical trial of clomipramine and diazepam in the treatment of phobic and obsessional illness. ( Waxman, D, 1977) |
| " The doses of modulators were selected on the basis of dose-response studies." | 1.39 | Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam. ( Bhutada, P; Deshmukh, P; Dixit, P; Kaulaskar, S; Thakur, K, 2013) |
| "pramipexole) known to produce compulsive behaviors in humans would increase marble burying." | 1.37 | Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety. ( Jimenez-Gomez, C; Osentoski, A; Woods, JH, 2011) |
| "One patient had hemifacial spasm." | 1.35 | Syndrome of fixed dystonia in adolescents--short term outcome in 4 cases. ( Colomer, J; Fernández-Alvarez, E; Galvan, M; Jardine, PE; Lingappa, L; López-Casas, J; Majumdar, A; Poo, P; Short, C, 2009) |
| "fluoxetine) anxiolytics inhibit marble burying." | 1.33 | A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants. ( Kolb, Y; Nicolas, LB; Prinssen, EP, 2006) |
| " Chronic administration of the selective serotonin re-uptake inhibitors fluoxetine and clomipramine (CMI) at 5 mg/kg per day and fluvoxamine at 10 mg/kg twice a day significantly decreased schedule-induced polydipsia (SIP) on day 15 and throughout the remainder of the study compared to control rats." | 1.29 | Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder. ( Corbett, R; Cornfeldt, M; Dunn, RW; Smith, C; Szewczak, M; Woods, A, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (67.50) | 18.7374 |
| 1990's | 4 (10.00) | 18.2507 |
| 2000's | 5 (12.50) | 29.6817 |
| 2010's | 4 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhutada, P | 1 |
| Dixit, P | 1 |
| Thakur, K | 1 |
| Deshmukh, P | 1 |
| Kaulaskar, S | 1 |
| Mukhopadhaya, K | 1 |
| Krishnaiah, R | 1 |
| Taye, T | 1 |
| Nigam, A | 1 |
| Bailey, AJ | 1 |
| Sivakumaran, T | 1 |
| Fineberg, NA | 1 |
| Majumdar, A | 1 |
| López-Casas, J | 1 |
| Poo, P | 1 |
| Colomer, J | 1 |
| Galvan, M | 1 |
| Lingappa, L | 1 |
| Short, C | 1 |
| Jardine, PE | 1 |
| Fernández-Alvarez, E | 1 |
| Kinsey, SG | 1 |
| O'Neal, ST | 1 |
| Long, JZ | 1 |
| Cravatt, BF | 1 |
| Lichtman, AH | 1 |
| Jimenez-Gomez, C | 1 |
| Osentoski, A | 1 |
| Woods, JH | 1 |
| Kreiss, DS | 1 |
| Coffman, CF | 1 |
| Fiacco, NR | 1 |
| Granger, JC | 1 |
| Helton, BM | 1 |
| Jackson, JC | 1 |
| Kim, LV | 1 |
| Mistry, RS | 1 |
| Mizer, TM | 1 |
| Palmer, LV | 1 |
| Vacca, JA | 1 |
| Winkler, SS | 1 |
| Zimmer, BA | 1 |
| VANHERCK, J | 1 |
| Geert-Joergensen, E | 1 |
| COLLARD, J | 1 |
| KERF, J | 1 |
| RONDEPIERRE, JJ | 1 |
| JOLIVET, B | 1 |
| BOEGNER-PLICHET, M | 1 |
| BETHUNE, HC | 1 |
| BURRELL, RH | 1 |
| CULPAN, RH | 1 |
| VENKOBARAO, A | 1 |
| DEBERDT, R | 1 |
| DEAN, SR | 2 |
| KRAUSE, G | 1 |
| LAANE, CL | 1 |
| Tsaltas, E | 1 |
| Kontis, D | 1 |
| Chrysikakou, S | 1 |
| Giannou, H | 1 |
| Biba, A | 1 |
| Pallidi, S | 1 |
| Christodoulou, A | 1 |
| Maillis, A | 1 |
| Rabavilas, A | 1 |
| Nicolas, LB | 1 |
| Kolb, Y | 1 |
| Prinssen, EP | 1 |
| Davis, JM | 1 |
| Nasr, S | 1 |
| Spira, N | 1 |
| Vogel, C | 1 |
| Stern, R | 1 |
| Woods, A | 1 |
| Smith, C | 1 |
| Szewczak, M | 1 |
| Dunn, RW | 1 |
| Cornfeldt, M | 1 |
| Corbett, R | 1 |
| Roy-Byrne, P | 1 |
| Wingerson, DK | 1 |
| Radant, A | 1 |
| Greenblatt, DJ | 1 |
| Cowley, DS | 1 |
| Kim, SW | 1 |
| Dysken, MW | 1 |
| Kushner, MG | 1 |
| Kuskowski, MA | 1 |
| Hoover, KM | 1 |
| Klein, KW | 1 |
| Faris, PL | 1 |
| Hartman, BK | 1 |
| Joel, D | 1 |
| Avisar, A | 1 |
| Cassano, GB | 1 |
| Carrara, S | 1 |
| Castrogiovanni, P | 1 |
| Dubnitskaia, EB | 1 |
| Basov, AM | 1 |
| Waxman, D | 1 |
| Kutin, VP | 1 |
| Kutin, GV | 1 |
| Kelly, D | 1 |
| Tyrer, P | 1 |
| Murphy, S | 1 |
| Ananth, J | 1 |
| Matthews, HP | 1 |
| Drummond, LM | 1 |
| Winstead, DK | 1 |
| Anderson, A | 1 |
| Eilers, MK | 1 |
| Blackwell, B | 1 |
| Zatemba, AL | 1 |
| Lens, F | 1 |
| Papeschi, R | 1 |
| Molina-Negro, P | 1 |
| Sourkes, TL | 1 |
| Erba, G | 1 |
| De Buck, R | 1 |
| Chassagnon, C | 1 |
| Franke, KH | 1 |
1 review available for diazepam and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Clomipramine: an antiobsessive drug.
Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive D | 1986 |
10 trials available for diazepam and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Anxiety: differential diagnosis and treatment from a biologic perspective.
Topics: Agoraphobia; Anxiety Disorders; Clinical Trials as Topic; Diagnosis, Differential; Diazepam; Double- | 1981 |
Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects.
Topics: Adult; Anti-Anxiety Agents; Arousal; Diazepam; Double-Blind Method; Female; Humans; Male; Memory, Sh | 1996 |
Phenomenological and pharmacological study of provoked obsessive/anxiety symptoms in obsessive-compulsive disorder: a preliminary study.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Blood Pressure; Diazepam; Double-Blind Method; Female; Heart Ra | 1997 |
Bromazepam versus diazepam in psychoneurotic inpatients.
Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety; Bromazepam; Diazepam; Drug Evaluation; Female; Humans; Ma | 1975 |
[Use of phenazepam in the treatment of neurotic conditions].
Topics: Adult; Affective Symptoms; Anti-Anxiety Agents; Benzodiazepines; Chemical Phenomena; Chemistry; Clin | 1978 |
A clinical trial of clomipramine and diazepam in the treatment of phobic and obsessional illness.
Topics: Adolescent; Adult; Aged; Clomipramine; Diazepam; Dibenzazepines; Female; Humans; Male; Medical Histo | 1977 |
Efficacy of combined antidepressant therapy in resistant neurotic disorder.
Topics: Adult; Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Diazepam; Do | 1990 |
Clomipramine: an antiobsessive drug.
Topics: Anxiety; Behavior Therapy; Clinical Trials as Topic; Clomipramine; Compulsive Behavior; Depressive D | 1986 |
[A new benzodiazepine screened in a parallel double-blind test].
Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety Disorders; Clinical Trials as Topic; Diazepam; Drug Evalua | 1974 |
Clinical experience with lorazepam in the treatment of neurotic patients.
Topics: Adult; Anxiety Disorders; Asthenia; Benzodiazepinones; Chlorobenzenes; Clinical Trials as Topic; Dia | 1973 |
30 other studies available for diazepam and Obsessive-Compulsive Disorder
| Article | Year |
|---|---|
Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam.
Topics: Acetamides; Animals; Antidepressive Agents; Behavior, Animal; Bicuculline; Diazepam; Disease Models, | 2013 |
Obsessive-compulsive disorder in UK clozapine-treated schizophrenia and schizoaffective disorder: a cause for clinical concern.
Topics: Adult; Antipsychotic Agents; Clozapine; Cohort Studies; Cross-Sectional Studies; Diazepam; Dose-Resp | 2009 |
Syndrome of fixed dystonia in adolescents--short term outcome in 4 cases.
Topics: Adolescent; Anxiety; Autonomic Nerve Block; Bites and Stings; Botulinum Toxins, Type A; Complex Regi | 2009 |
Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodioxoles; Cannabinoid Recepto | 2011 |
Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Benzothiazoles; Carbolin | 2011 |
Ritualistic chewing behavior induced by mCPP in the rat is an animal model of obsessive compulsive disorder.
Topics: Animals; Behavior, Animal; Clomipramine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Flu | 2013 |
[TRIAL CLINICAL EVALUATION OF A NEW TRANQUILIZER OF THE BENZODIAZEPINE GROUP].
Topics: Anxiety; Anxiety Disorders; Benzodiazepines; Chlordiazepoxide; Diazepam; Humans; Hypnotics and Sedat | 1963 |
TREATMENT OF ANXIETY NEUROSES AND PSYCHOSOMATIC SYNDROMES BY A NEW LIBRIUM-METABOLITE: VALIUM.
Topics: Anxiety; Anxiety Disorders; Asthenia; Chlordiazepoxide; Diazepam; Humans; Neurotic Disorders; Obsess | 1963 |
[A NEW ANXIOLYTIC AGENT: RO 5-2807 OR DIAZEPAM].
Topics: Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Diazepam; Humans; | 1963 |
[DIAZEPAM: A NEW ANXIOLYTIC AGENT].
Topics: Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Depression; Diazepam; Humans; Neurotic Disorders; O | 1964 |
A NEW COMPOUND IN THE TREATMENT OF SEVERE ANXIETY STATES. REPORT ON THE USE OF DIAZEPAM.
Topics: Antidepressive Agents; Anxiety; Anxiety Disorders; Diazepam; Neurotic Disorders; Obsessive-Compulsiv | 1964 |
A CONTROLLED TRIAL WITH 'VALIUM' IN OBSESSIVE COMPULSIVE STATE.
Topics: Anxiety; Anxiety Disorders; Biomedical Research; Diazepam; Drug Therapy; Humans; Neurotic Disorders; | 1964 |
[CLINICAL TRIAL OF A NEW TRANQUILIZER, A BENZODIAZEPINE SERIES DERIVATIVE: RO 5-2807].
Topics: Anxiety; Anxiety Disorders; Autonomic Nervous System Diseases; Benzodiazepines; Combat Disorders; De | 1964 |
DIAZEPAM AS AN ADJUVANT IN PSYCHOTHERAPY.
Topics: Adolescent; Anxiety; Bipolar Disorder; Depression; Depressive Disorder, Major; Diazepam; Drug Therap | 1964 |
DIAZEPAM AS AN ADJUVANT IN CLINICAL PSYCHOTHERAPY.
Topics: Anxiety; Anxiety Disorders; Depression; Diazepam; Drug Therapy; Neurotic Disorders; Obsessive-Compul | 1965 |
[RESTLESSNESS, COMPULSIONS, ANXIETY--STILL A THERAPEUTIC PROBLEM?].
Topics: Anxiety; Anxiety Disorders; Chlordiazepoxide; Compulsive Behavior; Diazepam; Humans; Neurotic Disord | 1964 |
[Experiences in policlinical treatment with librium analogue, Valium, with special reference to severe anxiety and compulsive neuroses].
Topics: Anxiety; Anxiety Disorders; Chlordiazepoxide; Compulsive Behavior; Diazepam; Humans; Neurotic Disord | 1962 |
Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Desipramine; Diazepam; Disease Model | 2005 |
A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Diazepa | 2006 |
Current issues in the treatment of anxiety states and disorders.
Topics: Anxiety; Anxiety Disorders; Diazepam; Humans; Obsessive-Compulsive Disorder | 1982 |
Psychotropic drugs and behaviour therapy.
Topics: Adult; Behavior Therapy; Clomipramine; Diazepam; Female; Humans; Male; Middle Aged; Obsessive-Compul | 1981 |
Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder.
Topics: Animals; Clomipramine; Conditioning, Operant; Desipramine; Diazepam; Disease Models, Animal; Drinkin | 1993 |
Excessive lever pressing following post-training signal attenuation in rats: a possible animal model of obsessive compulsive disorder?
Topics: Animals; Behavior, Animal; Conditioning, Operant; Cues; Diazepam; Disease Models, Animal; Fluoxetine | 2001 |
[Complex treatment of obsessive states of different etiology].
Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Benactyzine; Diazepam; Drug Therapy, Combination; | 1978 |
Physiological measurements in phobic and obsessional disorders.
Topics: Anxiety; Behavior Therapy; Blood Pressure; Cardiac Output; Chlordiazepoxide; Clomipramine; Diazepam; | 1975 |
Obsessive-compulsive disorder--a complication of benzodiazepine withdrawal.
Topics: Adult; Depression; Diazepam; Female; Humans; Obsessive-Compulsive Disorder; Substance Withdrawal Syn | 1987 |
Diazepam on demand. Drug-seeking behavior in psychiatric inpatients.
Topics: Anxiety; Attitude of Health Personnel; Black or African American; Circadian Rhythm; Diazepam; Drug P | 1974 |
The concentration of homovanillic and 5-hydroxyindoleacetic acids in ventricular and lumbar CSF. Studies in patients with extrapyramidal disorders, epilepsy, and other diseases.
Topics: Adolescent; Adult; Basal Ganglia Diseases; Cerebral Palsy; Cerebral Ventricles; Diazepam; Dihydroxyp | 1972 |
[On the use of Librium and Valium in general medicine, in adults].
Topics: Adolescent; Adult; Affective Symptoms; Aged; Anxiety; Anxiety Disorders; Chlordiazepoxide; Depressio | 1967 |
[On the treatment of phobias with a new anxiolytic drug].
Topics: Adjustment Disorders; Benzazepines; Chlordiazepoxide; Diazepam; Humans; Hypnotics and Sedatives; Neu | 1968 |