diazepam has been researched along with Obesity in 27 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The hyperphagia characteristic of some types of obesity may result from a deficiency in one or more components of the systems controlling satiety which in rats may include the gastrointestinal hormone cholecystokinin (CCK)." | 3.66 | Cholecystokinin, amphetamine and diazepam and feeding in lean and obese Zucker rats. ( Baile, CA; McLaughlin, CL, 1979) |
| " By measuring the brain function using computer period analysis of cerebral biopotentials, dose-efficacy relations were found (in the range of 25-75 mcg) which suggest the bioavailability of LHM at the CNS level." | 2.64 | Prediction of psychotropic properties of lisuride hydrogen maleate by quantitative pharmaco-electroencephalogram. ( Akpinar, S; Herrmann, WM; Itil, TM, 1975) |
| "Diazepam binding was slightly decreased in the obese as a result of lower serum albumin concentrations and elevated free fatty acids." | 1.27 | Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects. ( Benedek, IH; Blouin, RA; McNamara, PJ, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (66.67) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 2 (7.41) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Díaz, M | 1 |
| Blasco-Roset, A | 1 |
| Villarroya, J | 1 |
| López-Bermejo, A | 1 |
| de Zegher, F | 1 |
| Villarroya, F | 1 |
| Ibáñez, L | 1 |
| Reyes-Garcia, JG | 1 |
| Rodríguez-Flores, M | 1 |
| Kaufer-Horwitz, M | 1 |
| García-García, E | 1 |
| Rodriguiz, RM | 1 |
| Wilkins, JJ | 1 |
| Creson, TK | 1 |
| Biswas, R | 1 |
| Berezniuk, I | 1 |
| Fricker, AD | 1 |
| Fricker, LD | 1 |
| Wetsel, WC | 1 |
| CROMWELL, HA | 1 |
| Compton, R | 1 |
| Spiller, HA | 1 |
| Bosse, GM | 1 |
| Lima, SG | 1 |
| Nascimento, LS | 1 |
| Santos Filho, CN | 1 |
| Albuquerque, Mde F | 1 |
| Victor, EG | 1 |
| Benedek, IH | 2 |
| Blouin, RA | 2 |
| McNamara, PJ | 2 |
| Fiske, WD | 1 |
| Griffen, WO | 1 |
| Bell, RM | 1 |
| Borovskikh, NA | 1 |
| Sedletskiĭ, IuI | 1 |
| Abernethy, DR | 2 |
| Greenblatt, DJ | 2 |
| Divoll, M | 2 |
| Shader, RI | 2 |
| Harmatz, JS | 1 |
| Block, R | 1 |
| Jankowski, J | 1 |
| Johnston, D | 1 |
| Colvin, JR | 1 |
| Wormsley, KG | 1 |
| Smith, MR | 1 |
| Bell, GD | 1 |
| Baumann, P | 1 |
| Hedenstierna, G | 1 |
| Santesson, J | 1 |
| McLaughlin, CL | 1 |
| Baile, CA | 1 |
| Bandisode, MS | 1 |
| Boshell, BR | 1 |
| Itil, TM | 1 |
| Herrmann, WM | 1 |
| Akpinar, S | 1 |
| Lindahl, SG | 1 |
| Armstrong, PJ | 1 |
| Bersten, A | 1 |
| Peterson, DI | 1 |
| Zweig, RW | 1 |
| Borenstein, P | 1 |
| Champion, C | 1 |
| Cujo, P | 1 |
| Gekière, F | 1 |
| Olivenstein, C | 1 |
| Kramarz, P | 1 |
| Loscos Loscos, J | 1 |
| Cannella, M | 1 |
| Scarpelli, PT | 1 |
| Vailati, G | 1 |
| Plauchu, M | 1 |
| Malluret, J | 1 |
| Lachieze-Rey, E | 1 |
| Piquet, G | 1 |
| Eyraud, MT | 1 |
| Orgiazzi, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase I, Open-Label Study to Evaluate Potential Pharmacokinetic of Orally Administered Oseltamivir in Healthy Obese Thai Adult Subjects[NCT01049763] | Phase 1 | 24 participants (Actual) | Interventional | 2010-01-31 | Completed | ||
| Effects of Clonidine and Midazolam Premedication on Bispectral Index and Recovery After Elective Surgery[NCT00638729] | 60 participants (Actual) | Interventional | 2005-08-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diazepam and Obesity
| Article | Year |
|---|---|
[ECT: The apple of discord in modern psychiatry (author's transl)].
Topics: Aggression; Anxiety; Atropine; Biogenic Amines; Confusion; Cyclic AMP; Depression; Diazepam; Electro | 1979 |
The use of midazolam in premedication.
Topics: Anxiety; Diazepam; Half-Life; Humans; Midazolam; Obesity; Postoperative Period; Preanesthetic Medica | 1990 |
6 trials available for diazepam and Obesity
| Article | Year |
|---|---|
[Systemic hypertension at emergency units. The use of symptomatic drugs as choice for management].
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Determination; Captopril; Di | 2005 |
The administration of supplementary oxygen to prevent hypoxia during upper alimentary endoscopy.
Topics: Costs and Cost Analysis; Diazepam; Endoscopy, Gastrointestinal; Female; Humans; Hypoxia; Male; Midaz | 1993 |
Double-blind clinical evaluation of mazindol (42-548) in obese diabetics.
Topics: Body Weight; Clinical Trials as Topic; Diabetes Mellitus; Diazepam; Drug Evaluation; Female; Glucose | 1975 |
Prediction of psychotropic properties of lisuride hydrogen maleate by quantitative pharmaco-electroencephalogram.
Topics: Adolescent; Adult; Aged; Biological Availability; Child; Child, Preschool; Clinical Trials as Topic; | 1975 |
[An original psychotropic drug: sulpiride].
Topics: Adult; Animals; Anxiety; Behavior; Clinical Trials as Topic; Cognition Disorders; Delirium; Depressi | 1969 |
[The role of anorexic drugs in the treatment of obesity. Clinical data on the use of a new anorexic drug (Ro 6-1343)].
Topics: Adolescent; Adult; Appetite Depressants; Diazepam; Female; Humans; Male; Middle Aged; Morpholines; O | 1968 |
19 other studies available for diazepam and Obesity
| Article | Year |
|---|---|
Circulating diazepam-binding inhibitor in infancy: Relation to markers of adiposity and metabolic health.
Topics: Adiposity; Child, Preschool; Diabetes Mellitus, Type 2; Diazepam; Diazepam Binding Inhibitor; Humans | 2021 |
Safety of drug combinations based on psychoactive agents in the treatment of obesity (A reply by the authors).
Topics: Atropine; Diazepam; Drug Combinations; Emodin; Humans; Obesity; Phenylpropanolamine; Psychotropic Dr | 2019 |
Safety of drug combinations based on psychoactive agents in the treatment of obesity.
Topics: Atropine; Diazepam; Drug Combinations; Emodin; Humans; Obesity; Phenylpropanolamine; Psychotropic Dr | 2019 |
Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) mice.
Topics: Age Factors; Analysis of Variance; Animals; Antidepressive Agents; Anxiety; Carboxypeptidase H; Depr | 2013 |
CONTROLLED EVALUATION OF PSYCHOTHERAPEUTIC DRUG IN INTERNAL MEDICINE.
Topics: Alcoholism; Diazepam; Female; Geriatrics; Humans; Internal Medicine; Menopause; Neurotic Disorders; | 1963 |
Fatal fluoxetine ingestion with postmortem blood concentrations.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Second-Generation; Bradycardia; Child, Preschool; Dia | 2005 |
Serum protein binding and the role of increased alpha 1-acid glycoprotein in moderately obese male subjects.
Topics: Adolescent; Adult; Blood Proteins; Diazepam; Humans; Lipids; Lipoproteins; Male; Obesity; Orosomucoi | 1984 |
Serum alpha 1-acid glycoprotein and the binding of drugs in obesity.
Topics: Adult; Blood Proteins; Diazepam; Female; Humans; Obesity; Orosomucoid; Propranolol; Protein Binding | 1983 |
[Effect of combined anesthesia with ketalar on cardiohemodynamics in obese patients].
Topics: Adult; Anesthesia, Intravenous; Diazepam; Droperidol; Female; Hemodynamics; Humans; Ileum; Jejunum; | 1984 |
Prolongation of drug half-life due to obesity: studies of desmethyldiazepam (clorazepate).
Topics: Adult; Aged; Body Weight; Clorazepate Dipotassium; Diazepam; Female; Half-Life; Humans; Male; Middle | 1982 |
Alterations in drug distribution and clearance due to obesity.
Topics: Adult; Antipyrine; Diazepam; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; | 1981 |
Routine oxygen during endoscopy? An editorial review.
Topics: Costs and Cost Analysis; Diazepam; Endoscopy, Gastrointestinal; Humans; Hypoxia; Midazolam; Obesity; | 1993 |
Studies on intra-pulmonary gas distribution in the extremely obese. Influence of anaesthesia and artificial ventilation with and without positive end-expiratory pressure.
Topics: Adult; Anesthesia, Inhalation; Diazepam; Female; Forced Expiratory Flow Rates; Humans; Lung Volume M | 1977 |
Cholecystokinin, amphetamine and diazepam and feeding in lean and obese Zucker rats.
Topics: Animals; Body Weight; Cholecystokinin; Dextroamphetamine; Diazepam; Drug Interactions; Feeding Behav | 1979 |
Normeperidine toxicity.
Topics: Adult; Biotransformation; Colonic Neoplasms; Diazepam; Female; Humans; Injections, Intramuscular; Me | 1986 |
Absorption of anticonvulsants after jejunoileal bypass.
Topics: Adult; Anticonvulsants; Diazepam; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Ethosuximide; Female; H | 1974 |
The lazy respiratory center--or how to recognize a tired horse. Clinical conference in pulmonary disease from Northwestern University-McGaw Medical Center, Chicago.
Topics: Brain Diseases; Chemoreceptor Cells; Chronic Disease; Diagnosis, Differential; Diazepam; Digoxin; Fu | 1974 |
[Treatment of obesity using a new anorexigenic agent].
Topics: Adult; Appetite Depressants; Diazepam; Drug Synergism; Female; Humans; Male; Obesity; Phenethylamine | 1970 |
[On the use of diazepam in a general medicine department].
Topics: Adolescent; Adult; Aged; Alcoholic Intoxication; Anorexia Nervosa; Anxiety; Diazepam; Female; Humans | 1968 |