diazepam has been researched along with Neuroleptic Malignant Syndrome in 28 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of malignant catatonia initially diagnosed as neuroleptic malignant syndrome (NMS) that responded successfully to diazepam administration." | 7.77 | [Diazepam-responsive malignant catatonia in a patient with an initial clinical diagnosis of neuroleptic malignant syndrome: a case report]. ( Higuchi, MA; Mishima, T; Obata, T; Tsuboi, Y; Tsugawa, J; Yamada, T, 2011) |
| "We present the case of a 14-year-old female who had many characteristics of neuroleptic malignant syndrome (NMS) without pyrexia following a single depot injection of 200 mg of zuclopenthixol." | 7.74 | Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl. ( Bildik, T; Ercan, ES; Erermis, S; Gockay, A; Karasoy, H; Tamar, M, 2007) |
| "A 59-year-old man, who was diagnosed as having Parkinson's disease and depression seven years ago and was on oral antiparkinsonian agents, antianxiety agents, and antidepressants, developed a high fever, disturbed consciousness, and marked muscle rigidity after discontinuation of etizolam and amitriptyline." | 7.71 | [A patient with Parkinson's disease complicated by hypothyroidism who developed malignant syndrome after discontinuation of etizolam]. ( Araki, T; Esaki, S; Furuya, H; Inoue, N; Kawajiri, M; Kira, J; Ohyagi, Y; Yamada, T, 2002) |
| "A 1-year-old female presented with neuroleptic malignant syndrome probably caused by methylphenidate." | 7.70 | Neuroleptic malignant syndrome and methylphenidate. ( Ehara, H; Maegaki, Y; Takeshita, K, 1998) |
| "A mild form of neuroleptic malignant syndrome (NMS) in a schizophrenic patient who was receiving a depot neuroleptic is described and beneficial response to oral diazepam 50 mg daily is reported." | 7.67 | Treatment of a mild form of neuroleptic malignant syndrome with oral diazepam. ( Christodoulou, GN; Havaki-Kontaxaki, BJ; Kontaxakis, VP; Markidis, MP, 1988) |
| "We describe a case of neuroleptic malignant syndrome (NMS) associated with the use of ziprasidone." | 5.34 | Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment. ( Cansel, N; Herken, H; Ozen, ME; Savas, HA; Yumru, M, 2007) |
| "Cocaine-related rhabdomyolysis has a high mortality." | 5.29 | Rhabdomyolysis and hyperthermia after cocaine abuse: a variant of the neuroleptic malignant syndrome? ( Daras, M; Kakkouras, L; Koppel, BS; Tuchman, AJ, 1995) |
| "This article describes a patient with lethal catatonia: treatment by ECT alone was ineffective, whereas continued treatment with ECT in combination with dantrolene sodium led to improvement." | 5.28 | Treatment of lethal catatonia with electroconvulsive therapy and dantrolene sodium: a case report. ( Nolen, WA; Zwaan, WA, 1990) |
| "We present the case of a 14-year-old female who had many characteristics of neuroleptic malignant syndrome (NMS) without pyrexia following a single depot injection of 200 mg of zuclopenthixol." | 3.74 | Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl. ( Bildik, T; Ercan, ES; Erermis, S; Gockay, A; Karasoy, H; Tamar, M, 2007) |
| "A 59-year-old man, who was diagnosed as having Parkinson's disease and depression seven years ago and was on oral antiparkinsonian agents, antianxiety agents, and antidepressants, developed a high fever, disturbed consciousness, and marked muscle rigidity after discontinuation of etizolam and amitriptyline." | 3.71 | [A patient with Parkinson's disease complicated by hypothyroidism who developed malignant syndrome after discontinuation of etizolam]. ( Araki, T; Esaki, S; Furuya, H; Inoue, N; Kawajiri, M; Kira, J; Ohyagi, Y; Yamada, T, 2002) |
| "A 1-year-old female presented with neuroleptic malignant syndrome probably caused by methylphenidate." | 3.70 | Neuroleptic malignant syndrome and methylphenidate. ( Ehara, H; Maegaki, Y; Takeshita, K, 1998) |
| " He developed neuroleptic malignant syndrome (NMS) which was treated successfully with intravenous diazepam." | 3.69 | Catatonic syndrome following recovery from neuroleptic malignant syndrome. ( Dent, J, 1995) |
| "A mild form of neuroleptic malignant syndrome (NMS) in a schizophrenic patient who was receiving a depot neuroleptic is described and beneficial response to oral diazepam 50 mg daily is reported." | 3.67 | Treatment of a mild form of neuroleptic malignant syndrome with oral diazepam. ( Christodoulou, GN; Havaki-Kontaxaki, BJ; Kontaxakis, VP; Markidis, MP, 1988) |
| "Dantrolene was administered in a dose of 60 mg per day and he recovered consciousness and his CK level began to decrease." | 1.39 | [Neuroleptic malignant syndrome after cardiac surgery]. ( Fuzii, A; Higami, T; Inaoka, M; Miyaki, Y; Nakashima, S; Uehara, M, 2013) |
| "Thus, physician should consider catatonia when treating neuroleptic malignant like syndrome." | 1.36 | [Case with difficulty in differentiating between transient neuroleptic malignant syndrome and catatonia after neuroleptic analgesia]. ( Miyazaki, M; Yanagawa, Y, 2010) |
| "We describe a case of neuroleptic malignant syndrome (NMS) associated with the use of ziprasidone." | 1.34 | Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment. ( Cansel, N; Herken, H; Ozen, ME; Savas, HA; Yumru, M, 2007) |
| "Cocaine-related rhabdomyolysis has a high mortality." | 1.29 | Rhabdomyolysis and hyperthermia after cocaine abuse: a variant of the neuroleptic malignant syndrome? ( Daras, M; Kakkouras, L; Koppel, BS; Tuchman, AJ, 1995) |
| "Separate episodes of both catatonia and the so-called 'neuroleptic malignant syndrome' (NMS) occurred within the same patient." | 1.28 | Catatonia and the neuroleptic malignant syndrome--a single entity? ( White, DA, 1992) |
| "This article describes a patient with lethal catatonia: treatment by ECT alone was ineffective, whereas continued treatment with ECT in combination with dantrolene sodium led to improvement." | 1.28 | Treatment of lethal catatonia with electroconvulsive therapy and dantrolene sodium: a case report. ( Nolen, WA; Zwaan, WA, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (14.29) | 18.7374 |
| 1990's | 12 (42.86) | 18.2507 |
| 2000's | 8 (28.57) | 29.6817 |
| 2010's | 4 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kishimoto, S | 1 |
| Nakamura, K | 1 |
| Arai, T | 1 |
| Yukimasa, O | 1 |
| Fukami, N | 1 |
| Uehara, M | 1 |
| Inaoka, M | 1 |
| Miyaki, Y | 1 |
| Nakashima, S | 1 |
| Fuzii, A | 1 |
| Higami, T | 1 |
| Yanagawa, Y | 1 |
| Miyazaki, M | 1 |
| Mishima, T | 1 |
| Tsuboi, Y | 1 |
| Higuchi, MA | 1 |
| Tsugawa, J | 1 |
| Obata, T | 1 |
| Yamada, T | 2 |
| Kawajiri, M | 1 |
| Ohyagi, Y | 1 |
| Furuya, H | 1 |
| Araki, T | 1 |
| Inoue, N | 1 |
| Esaki, S | 1 |
| Kira, J | 1 |
| Nishijima, K | 1 |
| Brieger, P | 1 |
| Reinelt, Y | 1 |
| Meagher, LJ | 1 |
| McKay, D | 1 |
| Herkes, GK | 1 |
| Needham, M | 1 |
| Ozen, ME | 1 |
| Yumru, M | 1 |
| Savas, HA | 1 |
| Cansel, N | 1 |
| Herken, H | 1 |
| Erermis, S | 1 |
| Bildik, T | 1 |
| Tamar, M | 1 |
| Gockay, A | 1 |
| Karasoy, H | 1 |
| Ercan, ES | 1 |
| Daras, M | 1 |
| Kakkouras, L | 1 |
| Tuchman, AJ | 1 |
| Koppel, BS | 1 |
| Maier, U | 1 |
| Aigner, JM | 1 |
| Klein, HE | 1 |
| Dent, J | 1 |
| Real Rodríguez, B | 1 |
| Ruibal, JL | 1 |
| Grande Rodríguez, S | 1 |
| Sueiro Pita, B | 1 |
| Miyaoka, H | 1 |
| Shishikura, K | 1 |
| Otsubo, T | 1 |
| Muramatsu, D | 1 |
| Kamijima, K | 1 |
| Ehara, H | 1 |
| Maegaki, Y | 1 |
| Takeshita, K | 1 |
| Yoshino, A | 1 |
| Yoshimasu, H | 1 |
| Roffe, C | 1 |
| White, DA | 1 |
| Velamoor, VR | 1 |
| Sczesni, B | 1 |
| Becker, H | 1 |
| Schröder, J | 1 |
| Bittkau, S | 1 |
| von Baumgarten, F | 1 |
| Truong, DD | 1 |
| Przuntek, H | 1 |
| Usandizaga, I | 1 |
| Pérez de Mendiola, MM | 1 |
| Buades, J | 1 |
| Martínez, J | 1 |
| Frankenburg, FR | 1 |
| Nolen, WA | 1 |
| Zwaan, WA | 1 |
| O'Brien, P | 1 |
| Kontaxakis, VP | 1 |
| Christodoulou, GN | 1 |
| Markidis, MP | 1 |
| Havaki-Kontaxaki, BJ | 1 |
| Kumar, V | 1 |
| Lazarus, A | 1 |
3 reviews available for diazepam and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
[Neuroleptic malignant syndrome].
Topics: Antipsychotic Agents; Bromocriptine; Dantrolene; Diagnosis, Differential; Diazepam; Dopamine D2 Rece | 2003 |
[Hypothermia caused by neuroleptics. 2 case reports and review of the literature].
Topics: Administration, Oral; Adult; Antipsychotic Agents; Benperidol; Body Temperature; Diazepam; Dose-Resp | 1994 |
[The neuroleptic malignant syndrome in an adolescent. Its treatment with dantrolene, bromocryptin and diazepam].
Topics: Adolescent; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antiparkinson Agents; Antipsychot | 1996 |
25 other studies available for diazepam and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
Postoperative neuroleptic malignant syndrome-like symptoms improved with intravenous diazepam: a case report.
Topics: Administration, Intravenous; Aged; Benzodiazepines; Diazepam; Humans; Male; Neuroleptic Malignant Sy | 2013 |
[Neuroleptic malignant syndrome after cardiac surgery].
Topics: Aortic Valve; Buprenorphine; Dantrolene; Diazepam; Endocarditis; Flunitrazepam; Humans; Male; Middle | 2013 |
[Case with difficulty in differentiating between transient neuroleptic malignant syndrome and catatonia after neuroleptic analgesia].
Topics: Adolescent; Analgesia; Anesthesia, General; Catatonia; Diagnosis, Differential; Diazepam; Droperidol | 2010 |
[Diazepam-responsive malignant catatonia in a patient with an initial clinical diagnosis of neuroleptic malignant syndrome: a case report].
Topics: Adult; Biomarkers; Catatonia; Creatine Kinase; Diagnosis, Differential; Diazepam; Humans; Male; Musc | 2011 |
[A patient with Parkinson's disease complicated by hypothyroidism who developed malignant syndrome after discontinuation of etizolam].
Topics: Antidepressive Agents; Depression; Diazepam; Humans; Hypothyroidism; Male; Middle Aged; Neuroleptic | 2002 |
No recurrence of a neuroleptic malignant syndrome under quetiapine.
Topics: Anticonvulsants; Antipsychotic Agents; Diazepam; Dibenzothiazepines; Drug Therapy, Combination; Halo | 2003 |
Parkinsonism-hyperpyrexia syndrome: the role of electroconvulsive therapy.
Topics: Acetaminophen; Acyclovir; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Anxiety Agents; Anti-Ba | 2006 |
Neuroleptic malignant syndrome induced by ziprasidone on the second day of treatment.
Topics: Adult; Antipsychotic Agents; Biperiden; Diagnosis, Differential; Diazepam; Drug Therapy, Combination | 2007 |
Zuclopenthixol-induced neuroleptic malignant syndrome in an adolescent girl.
Topics: Adolescent; Anti-Anxiety Agents; Antidotes; Antipsychotic Agents; Bromocriptine; Clopenthixol; Delay | 2007 |
Rhabdomyolysis and hyperthermia after cocaine abuse: a variant of the neuroleptic malignant syndrome?
Topics: Adult; Antipsychotic Agents; Brain; Cell Death; Cocaine; Diagnosis, Differential; Diazepam; Female; | 1995 |
Catatonic syndrome following recovery from neuroleptic malignant syndrome.
Topics: Anti-Anxiety Agents; Antipsychotic Agents; Catatonia; Chlorpromazine; Diazepam; Dose-Response Relati | 1995 |
Diazepam-responsive neuroleptic malignant syndrome: a diagnostic subtype?
Topics: Antipsychotic Agents; Catatonia; Diazepam; Female; Humans; Infusions, Intravenous; Middle Aged; Neur | 1997 |
Neuroleptic malignant syndrome and methylphenidate.
Topics: Brain; Diazepam; Female; GABA Modulators; Humans; Infant; Infant, Newborn; Methylphenidate; Neurolep | 1998 |
Nonconvulsive status epilepticus complicating neuroleptic malignant syndrome improved by intravenous diazepam.
Topics: Anticonvulsants; Diazepam; Electroencephalography; Humans; Injections, Intravenous; Male; Middle Age | 2000 |
Nonconvulsive status epilepticus causing acute confusion.
Topics: Aged; Anti-Anxiety Agents; Diazepam; Female; Humans; Neuroleptic Malignant Syndrome; Status Epilepti | 2001 |
Catatonia and the neuroleptic malignant syndrome--a single entity?
Topics: Adult; Catatonia; Chlorpromazine; Diazepam; Female; Follow-Up Studies; Humans; Neuroleptic Malignant | 1992 |
NMS complicated by diazepam.
Topics: Aged; Coma; Diazepam; Haloperidol; Humans; Male; Neuroleptic Malignant Syndrome; Risk Factors; Schiz | 1992 |
[Diagnostic and therapeutic aspects of neuroleptic malignant syndrome based on 12 cases].
Topics: Adult; Amantadine; Antipsychotic Agents; Bromocriptine; Dantrolene; Depressive Disorder; Diazepam; D | 1991 |
[Neuroleptic malignant syndrome].
Topics: Adult; Biperiden; Chlormethiazole; Chlorpromazine; Dantrolene; Diazepam; Female; Haloperidol; Humans | 1990 |
Neuroleptic malignant syndrome.
Topics: Adult; Diazepam; Drug Therapy, Combination; Humans; Lithium; Male; Neuroleptic Malignant Syndrome; R | 1990 |
Treatment of lethal catatonia with electroconvulsive therapy and dantrolene sodium: a case report.
Topics: Adolescent; Catatonia; Combined Modality Therapy; Dantrolene; Diazepam; Electroconvulsive Therapy; H | 1990 |
Neuroleptic malignant syndrome treated with Diazepam.
Topics: Brain; Diazepam; Humans; Infusions, Intravenous; Neuroleptic Malignant Syndrome; Receptors, GABA-A | 1988 |
Treatment of a mild form of neuroleptic malignant syndrome with oral diazepam.
Topics: Administration, Oral; Adult; Diazepam; Drug Therapy, Combination; Fluphenazine; Humans; Injections, | 1988 |
A case of neuroleptic malignant syndrome treated with diazepam.
Topics: Aged; Amantadine; Diazepam; Humans; Male; Neuroleptic Malignant Syndrome; Substance Withdrawal Syndr | 1987 |
Therapy of neuroleptic malignant syndrome.
Topics: Amantadine; Bromocriptine; Carbidopa; Combined Modality Therapy; Dantrolene; Diazepam; Dose-Response | 1986 |