diazepam has been researched along with Neural Tube Defects in 3 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Neural Tube Defects: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy generally occurring between days 18-29 of gestation. Ectodermal and mesodermal malformations (mainly involving the skull and vertebrae) may occur as a result of defects of neural tube closure. (From Joynt, Clinical Neurology, 1992, Ch55, pp31-41)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The biomechanical basis of diazepam (Valium/Roche)-induced neural tube defects in the chick was investigated using a combination of electron microscopy and morphometry." | 7.67 | Biomechanical basis of diazepam-induced neural tube defects in early chick embryos: a morphometric study. ( Bush, KT; Hunter, ET; Kosciuk, MC; Lee, H; Nagele, RG, 1989) |
| "The biomechanical basis of diazepam (Valium/Roche)-induced neural tube defects in the chick was investigated using a combination of electron microscopy and morphometry." | 3.67 | Biomechanical basis of diazepam-induced neural tube defects in early chick embryos: a morphometric study. ( Bush, KT; Hunter, ET; Kosciuk, MC; Lee, H; Nagele, RG, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, HY | 1 |
| Keresztury, MF | 1 |
| Kosciuk, MC | 2 |
| Nagele, RG | 3 |
| Roisen, FJ | 1 |
| Pietrolungo, JF | 1 |
| Lee, H | 2 |
| Roisen, F | 1 |
| Bush, KT | 1 |
| Hunter, ET | 1 |
3 other studies available for diazepam and Neural Tube Defects
| Article | Year |
|---|---|
Diazepam inhibits neurulation through its action on myosin-containing microfilaments in early chick embryos.
Topics: Animals; Chick Embryo; Cytoskeleton; Diazepam; In Vitro Techniques; Myosins; Nervous System; Neural | 1984 |
Diazepam-induced neural tube closure defects in explanted early chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Chick Embryo; Diazepam; Dose-Response Relationship, Dru | 1981 |
Biomechanical basis of diazepam-induced neural tube defects in early chick embryos: a morphometric study.
Topics: Animals; Brain; Chick Embryo; Diazepam; Mesencephalon; Microscopy, Electron; Neural Tube Defects; Ph | 1989 |