diazepam has been researched along with Nerve Degeneration in 23 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats." | 7.80 | The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014) |
| "Injection of the seaweed toxin kainic acid (KA) in rats induces a severe status epilepticus initiating complex neuropathological changes in limbic brain areas and subsequently spontaneous recurrent seizures." | 7.78 | Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex. ( Drexel, M; Preidt, AP; Sperk, G, 2012) |
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 7.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| "Morphological analysis of brains from rats receiving a convulsant dose of the muscarinic cholinergic agonist, pilocarpine hydrochloride (380 mg/kg), revealed a widespread damage to the forebrain as assessed by light microscopy 5-7 days after seizures." | 7.67 | Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain. ( Cavalheiro, EA; Czuczwar, SJ; Ikonomidou-Turski, C; Sieklucka-Dziuba, M; Turski, L; Turski, WA, 1986) |
| " Here, we compared the efficacy of DZP with that of UBP302 [(S)-3-(2-carboxybenzyl)willardiine; an antagonist of the kainate receptors that contain the GluK1 subunit] against seizures, neuropathology, and behavioral deficits induced by soman in rats." | 3.80 | The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302. ( Apland, JP; Aroniadou-Anderjaska, V; Braga, MF; Figueiredo, TH; Miller, SL; Rossetti, F, 2014) |
| "Injection of the seaweed toxin kainic acid (KA) in rats induces a severe status epilepticus initiating complex neuropathological changes in limbic brain areas and subsequently spontaneous recurrent seizures." | 3.78 | Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex. ( Drexel, M; Preidt, AP; Sperk, G, 2012) |
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 3.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| "Morphological analysis of brains from rats receiving a convulsant dose of the muscarinic cholinergic agonist, pilocarpine hydrochloride (380 mg/kg), revealed a widespread damage to the forebrain as assessed by light microscopy 5-7 days after seizures." | 3.67 | Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain. ( Cavalheiro, EA; Czuczwar, SJ; Ikonomidou-Turski, C; Sieklucka-Dziuba, M; Turski, L; Turski, WA, 1986) |
| "Increased seizure duration [3,522 +/- 660 sec (SEM) vs." | 1.33 | Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity. ( Allan, SM; Davies, RE; Heenan, LE; Patel, HC; Ross, FM; Rothwell, NJ, 2006) |
| "Treatment with diazepam completely protected CA1b hippocampal pyramidal neurons in 94% of the animals and partially protected pyramidal neurons in 6% of the animals, as assessed with a standard Nissl stain three and four days after ischemia." | 1.31 | Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study. ( Crain, BJ; Evenson, DA; Miller, KA; Nadler, JV; Schwartz-Bloom, RD, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (13.04) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 9 (39.13) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Apland, JP | 2 |
| Aroniadou-Anderjaska, V | 2 |
| Figueiredo, TH | 2 |
| Rossetti, F | 1 |
| Miller, SL | 1 |
| Braga, MF | 2 |
| Suchomelova, L | 1 |
| Lopez-Meraz, ML | 1 |
| Niquet, J | 1 |
| Kubova, H | 1 |
| Wasterlain, CG | 1 |
| Kanungo, AK | 1 |
| Liadis, N | 1 |
| Robertson, J | 1 |
| Woo, M | 1 |
| Henderson, JT | 1 |
| Qashu, F | 1 |
| Luongo, R | 1 |
| Oliveira, DA | 1 |
| Lebrun, I | 1 |
| Sandoval, MR | 1 |
| Drexel, M | 1 |
| Preidt, AP | 1 |
| Sperk, G | 1 |
| Bittigau, P | 1 |
| Sifringer, M | 1 |
| Genz, K | 1 |
| Reith, E | 1 |
| Pospischil, D | 1 |
| Govindarajalu, S | 1 |
| Dzietko, M | 1 |
| Pesditschek, S | 1 |
| Mai, I | 1 |
| Dikranian, K | 1 |
| Olney, JW | 2 |
| Ikonomidou, C | 1 |
| Jevtovic-Todorovic, V | 1 |
| Beals, J | 1 |
| Benshoff, N | 1 |
| Fredriksson, A | 1 |
| Archer, T | 1 |
| Patel, HC | 1 |
| Ross, FM | 1 |
| Heenan, LE | 1 |
| Davies, RE | 1 |
| Rothwell, NJ | 1 |
| Allan, SM | 1 |
| Engelhorn, T | 1 |
| Weise, J | 1 |
| Hammen, T | 1 |
| Bluemcke, I | 1 |
| Hufnagel, A | 1 |
| Doerfler, A | 1 |
| Marqués-Marí, AI | 1 |
| Nacher, J | 1 |
| Crespo, C | 1 |
| Gutièrrez-Mecinas, M | 1 |
| Martínez-Guijarro, FJ | 1 |
| Blasco-Ibáñez, JM | 1 |
| Lemos, T | 1 |
| Cavalheiro, EA | 2 |
| Karle, J | 1 |
| Witt, MR | 1 |
| Nielsen, M | 1 |
| Hall, ED | 1 |
| Fleck, TJ | 1 |
| Oostveen, JA | 1 |
| Lokensgard, JR | 1 |
| Chao, CC | 1 |
| Gekker, G | 1 |
| Hu, S | 1 |
| Peterson, PK | 1 |
| Schwartz-Bloom, RD | 1 |
| Miller, KA | 1 |
| Evenson, DA | 1 |
| Crain, BJ | 1 |
| Nadler, JV | 1 |
| Skolnick, P | 1 |
| Syapin, PJ | 1 |
| Paugh, BA | 1 |
| Paul, SM | 1 |
| Ben-Ari, Y | 1 |
| Tremblay, E | 1 |
| Ottersen, OP | 1 |
| Naquet, R | 1 |
| Bowery, NG | 1 |
| Bagetta, G | 1 |
| Nisticó, G | 1 |
| Britton, P | 1 |
| Whitton, P | 1 |
| Johansen, FF | 1 |
| Diemer, NH | 1 |
| Bakker, MH | 1 |
| Foster, AC | 1 |
| Turski, L | 1 |
| Sieklucka-Dziuba, M | 1 |
| Ikonomidou-Turski, C | 1 |
| Czuczwar, SJ | 1 |
| Turski, WA | 1 |
1 review available for diazepam and Nerve Degeneration
| Article | Year |
|---|---|
Benzodiazepines, glia, and HIV-1 neuropathogenesis.
Topics: AIDS Dementia Complex; Anti-HIV Agents; Benzodiazepines; Clonazepam; Diazepam; Drug Design; Gene Exp | 1998 |
22 other studies available for diazepam and Nerve Degeneration
| Article | Year |
|---|---|
The limitations of diazepam as a treatment for nerve agent-induced seizures and neuropathology in rats: comparison with UBP302.
Topics: Alanine; Amygdala; Animals; Anticonvulsants; Anxiety; Diazepam; Hippocampus; Male; Nerve Degeneratio | 2014 |
Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Cell Death; Di | 2015 |
Excitatory tonus is required for the survival of granule cell precursors during postnatal development within the cerebellum.
Topics: Analysis of Variance; Animals; Animals, Newborn; Bromodeoxyuridine; Caspase 3; Cell Death; Cerebellu | 2009 |
Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis.
Topics: Amygdala; Animals; Diazepam; Epilepsy; Hippocampus; Male; Nerve Degeneration; Random Allocation; Rat | 2010 |
Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Cell Death; Diazepam; Electroencephalogr | 2009 |
Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex.
Topics: Animals; Anticonvulsants; Astrocytes; Diazepam; Disease Models, Animal; Drug Resistance; Entorhinal | 2012 |
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain.
Topics: Animals; Anticonvulsants; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Diazepam; Disease Mod | 2002 |
Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain.
Topics: Analysis of Variance; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Brain; Cell Death; Diaze | 2003 |
Neurobehavioural deficits associated with apoptotic neurodegeneration and vulnerability for ADHD.
Topics: Animals; Animals, Newborn; Apoptosis; Attention Deficit Disorder with Hyperactivity; Central Nervous | 2004 |
Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Anticonvuls | 2006 |
Early diffusion-weighted MRI predicts regional neuronal damage in generalized status epilepticus in rats treated with diazepam.
Topics: Animals; Anticonvulsants; Brain; Brain Damage, Chronic; Convulsants; Diazepam; Diffusion; Diffusion | 2007 |
Loss of input from the mossy cells blocks maturation of newly generated granule cells.
Topics: Animals; Anticonvulsants; Biomarkers; Bromodeoxyuridine; Calbindin 2; Cell Differentiation; Cell Pro | 2007 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Diazepam protects against rat hippocampal neuronal cell death induced by antisense oligodeoxynucleotide to GABA(A) receptor gamma2 subunit.
Topics: Animals; Cell Death; Diazepam; Flunitrazepam; GABA Modulators; Hippocampus; Male; Muscarinic Antagon | 1997 |
Comparative neuroprotective properties of the benzodiazepine receptor full agonist diazepam and the partial agonist PNU-101017 in the gerbil forebrain ischemia model.
Topics: Animals; Brain Ischemia; Diazepam; GABA Agonists; GABA-A Receptor Agonists; Gerbillinae; Hippocampus | 1998 |
Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study.
Topics: Animals; Apoptosis; Benzodiazepines; Diazepam; DNA Fragmentation; GABA Modulators; Gerbillinae; Imid | 2000 |
Reduction in benzodiazepine receptors associated with Purkinje cell degeneration in 'nervous' mutant mice.
Topics: Animals; Benzodiazepines; Diazepam; Mice; Mice, Neurologic Mutants; Nerve Degeneration; Purkinje Cel | 1979 |
Evidence suggesting secondary epileptogenic lesion after kainic acid: pre treatment with diazepam reduces distant but not local brain damage.
Topics: Amygdala; Animals; Diazepam; Hippocampus; Kainic Acid; Nerve Degeneration; Neural Pathways; Premedic | 1979 |
Intrahippocampal tetanus toxin produces generalized convulsions and neurodegeneration in rats: antagonism by NMDA receptor blockers.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dizocilpine Maleate; | 1992 |
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells.
Topics: Animals; Arousal; Brain Ischemia; Cell Count; Cell Survival; Diazepam; Dose-Response Relationship, D | 1991 |
An investigation of the mechanisms of delayed neurodegeneration caused by direct injection of quinolinate into the rat striatum in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Convulsants; Corpus Striatum; Dialysis; Diaz | 1991 |
Seizures produced by pilocarpine: neuropathological sequelae and activity of glutamate decarboxylase in the rat forebrain.
Topics: Animals; Behavior, Animal; Brain; Diazepam; Electroencephalography; Glutamate Decarboxylase; Male; N | 1986 |