diazepam and Morphine Dependence
diazepam has been researched along with Morphine Dependence in 24 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Naloxone was injected (5 mg/kg, s." | 5.31 | Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice. ( Hosseinzadeh, H; Mojtahedi, K; Ramezani, M, 2001) |
"In this study, we investigated whether morphine dependence was inhibited by phosphodiesterase (PDE) 4 inhibitors rolipram and diazepam, since a role for the cyclic AMP systems in the development of morphine dependence was reported." | 3.74 | Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heart. ( González-Cuello, A; Hernández, J; Laorden, ML; Sánchez, L; Teresa Castells, M; Victoria Milanés, M, 2007) |
"Naloxone was injected (5 mg/kg, s." | 1.31 | Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice. ( Hosseinzadeh, H; Mojtahedi, K; Ramezani, M, 2001) |
"Diazepam (0." | 1.29 | Inhibition of morphine tolerance and dependence by diazepam and its relation to cyclic AMP levels in discrete rat brain regions and spinal cord. ( Santosa, DN; Sheu, MJ; Sribanditmongkol, P; Tejwani, GA, 1995) |
"7 mg/kg/day), on the gradedly increased dosage schedule with a dosage level of 0." | 1.27 | [Physical dependence liability test of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) in rats]. ( Imamaki, H; Ogawa, K; Suzuki, T; Yanaura, S; Yoshii, T, 1987) |
"Diazepam was ineffective in the analgesic test and it did not alter morphine analgesia, except when administered in a high dose which decreased and analgesic response." | 1.26 | Effects of glycine, beta-alanine and diazepam upon morphine-tolerant-dependent mice. ( Contreras, E; Tamayo, L, 1980) |
"Thrombocytosis was not related to withdrawal symptoms or treatment (phenobarbital or paregoric)." | 1.26 | Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users. ( Burstein, Y; Giardina, PJ; Kandall, SR; Peterson, CM; Rausen, AR; Siljestrom, K, 1979) |
" Physical dependence on phenobarbital and diazepam was produced using the same dosage schedules as with morphine." | 1.25 | Physical dependence on morphine, phenobarbital and diazepam in rats by drug-admixed food ingestion. ( Suzuki, T; Tagashira, E; Yanaura, S, 1975) |
Research
Studies (24)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 19 (79.17) | 18.7374 |
1990's | 2 (8.33) | 18.2507 |
2000's | 2 (8.33) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (4.17) | 2.80 |
Authors
Authors | Studies |
---|---|
Konstantinopolsky, MA | 1 |
Chernyakova, IV | 1 |
Kolik, LG | 1 |
González-Cuello, A | 1 |
Sánchez, L | 1 |
Hernández, J | 1 |
Teresa Castells, M | 1 |
Victoria Milanés, M | 1 |
Laorden, ML | 1 |
Contreras, E | 1 |
Tamayo, L | 1 |
Yoshimura, K | 2 |
Horiuchi, M | 1 |
Inoue, Y | 1 |
Yamamoto, K | 2 |
Ryser, PE | 1 |
Eisenberg, RM | 2 |
Wiechman, BE | 1 |
Spratto, GR | 1 |
Sheu, MJ | 1 |
Sribanditmongkol, P | 1 |
Santosa, DN | 1 |
Tejwani, GA | 1 |
Suzuki, T | 3 |
Tsuda, M | 1 |
Narita, M | 1 |
Funada, M | 1 |
Mizoguchi, H | 1 |
Misawa, M | 1 |
Ramezani, M | 1 |
Hosseinzadeh, H | 1 |
Mojtahedi, K | 1 |
Baldino, F | 1 |
Cowan, A | 1 |
Geller, EB | 1 |
Adler, MW | 1 |
Burstein, Y | 1 |
Giardina, PJ | 1 |
Rausen, AR | 1 |
Kandall, SR | 1 |
Siljestrom, K | 1 |
Peterson, CM | 1 |
Killam, KF | 1 |
Brocco, MJ | 1 |
Robinson, CA | 1 |
Yanaura, S | 3 |
Tagashire, E | 1 |
Tagashira, E | 1 |
Gibert-Rahola, J | 1 |
Maldonado, R | 1 |
Micó, JA | 1 |
Leonsegui, I | 1 |
Saavedra, MC | 1 |
Imamaki, H | 1 |
Yoshii, T | 1 |
Ogawa, K | 1 |
Antonelli, T | 1 |
Beani, L | 1 |
Bianchi, C | 1 |
Rando, S | 1 |
Simonato, M | 1 |
Tanganelli, S | 1 |
Kreuzer, A | 1 |
Kamei, C | 1 |
Shimomura, K | 1 |
Ueki, S | 1 |
Leuner, H | 1 |
Nathenson, G | 1 |
Cohen, MI | 1 |
Litt, IF | 1 |
McNamara, H | 1 |
Other Studies
24 other studies available for diazepam and Morphine Dependence
Article | Year |
---|---|
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
Topics: Animals; Diazepam; Morphine; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome; Tuf | 2022 |
Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heart.
Topics: Animals; Cyclic AMP; Cyclic GMP; Diazepam; Male; Morphine Dependence; Myocardium; Norepinephrine; No | 2007 |
Effects of glycine, beta-alanine and diazepam upon morphine-tolerant-dependent mice.
Topics: Alanine; Analgesia; Animals; beta-Alanine; Diazepam; Drug Interactions; Drug Tolerance; Female; Glyc | 1980 |
[Pharmacological studies on drug dependence. (III): Intravenous self-administration of some CNS-affecting drugs and a new sleep-inducer, 1H-1, 2, 4-triazolyl benzophenone derivative (450191-S), in rats].
Topics: Animals; Central Nervous System Agents; Cocaine; Diazepam; Humans; Hypnotics and Sedatives; Injectio | 1984 |
Sex differences in substance abuse: 1976-1979.
Topics: Alcohol Drinking; Diazepam; Female; Heroin Dependence; Humans; Illicit Drugs; Male; Morphine Depende | 1983 |
Further studies on the acute dependence produced by morphine in opiate naive rats.
Topics: Amphetamine; Animals; Corticosterone; Diazepam; Drug Tolerance; Humans; Male; Morphine; Morphine Dep | 1982 |
Body temperature response to cocaine and diazepam in morphine-treated rats.
Topics: Animals; Body Temperature; Cocaine; Diazepam; Drug Interactions; Humans; Male; Morphine; Morphine De | 1982 |
[Neuropharmacological studies on drug dependence (II). Changes in spontaneous motor activity, EEG and brain monoamines during the period of dependence development and of abrupt withdrawal in rats, with special reference to circadian rhythm (author's trans
Topics: Animals; Biogenic Amines; Brain; Circadian Rhythm; Cocaine; Diazepam; Electroencephalography; Humans | 1980 |
Inhibition of morphine tolerance and dependence by diazepam and its relation to cyclic AMP levels in discrete rat brain regions and spinal cord.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Cyclic AMP; Diazepam; Drug Implants; Dr | 1995 |
Diazepam pretreatment suppresses morphine withdrawal signs in the mouse.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anticonvulsants; Cerebr | 1996 |
Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice.
Topics: Administration, Cutaneous; Animals; Diazepam; Ferula; Hypnotics and Sedatives; Iran; Male; Medicine, | 2001 |
Effects of antipsychotic and antianxiety drugs on the morphine abstinence syndrome in rats.
Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Body Weight; Chlordiazepoxide; | 1979 |
Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users.
Topics: Amphetamine; Cocaine; Diazepam; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Infant, | 1979 |
Evaluation of narcotic and narcotic antagonist interactions in primates.
Topics: Animals; Cyclazocine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Haplorhini; H | 1976 |
[Dependence on and preference for morphine (II). Comparison among morphine, phenobarbital and diazepam].
Topics: Animals; Body Weight; Choice Behavior; Decision Making; Diazepam; Female; Humans; Male; Methods; Mor | 1975 |
Physical dependence on morphine, phenobarbital and diazepam in rats by drug-admixed food ingestion.
Topics: Animals; Body Weight; Diazepam; Diet; Feeding Behavior; Female; Humans; Levallorphan; Male; Morphine | 1975 |
Comparative study in mice of flunitrazepam vs. diazepam on morphine withdrawal syndrome.
Topics: Animals; Behavior, Animal; Diazepam; Flunitrazepam; Male; Mice; Mice, Inbred Strains; Morphine; Morp | 1988 |
[Physical dependence liability test of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) in rats].
Topics: Animals; Antidepressive Agents; Barbiturates; Benzhydryl Compounds; Body Weight; Codeine; Diazepam; | 1987 |
Cortical acetylcholine release is increased and gamma-aminobutyric acid outflow is reduced during morphine withdrawal.
Topics: Acetylcholine; Animals; Atropine; Cerebral Cortex; Diazepam; Female; gamma-Aminobutyric Acid; Guinea | 1986 |
Effects of chronic treatment with diazepam, phenobarbital, or amphetamine on naloxone-precipitated morphine withdrawal.
Topics: Amphetamine; Animals; Corticosterone; Diazepam; Male; Mice; Morphine Dependence; Motor Activity; Nal | 1985 |
[Surreptitious acquisition of medical prescriptions. Criminologic studies on drugs and deliquency].
Topics: Adolescent; Adult; Central Nervous System Stimulants; Criminology; Deception; Diazepam; Drug and Nar | 1974 |
Significance of withdrawal jumping response in predicting physical dependence in mice.
Topics: Amitriptyline; Animals; Atropine; Cannabis; Chlordiazepoxide; Chlorpromazine; Diazepam; Humans; Imip | 1973 |
[Acute psychiatric complications due to drug abuse and their therapy].
Topics: Adolescent; Diazepam; Humans; Injections, Intravenous; Levallorphan; Morphine Dependence; Nalorphine | 1972 |
The effect of maternal heroin addiction on neonatal jaundice.
Topics: Animals; Bilirubin; Diazepam; Endoplasmic Reticulum; Female; Glucuronates; Heroin; Hexosyltransferas | 1972 |