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diazepam and Morphine Dependence

diazepam has been researched along with Morphine Dependence in 24 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.

Research Excerpts

ExcerptRelevanceReference
"Naloxone was injected (5 mg/kg, s."5.31Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice. ( Hosseinzadeh, H; Mojtahedi, K; Ramezani, M, 2001)
"In this study, we investigated whether morphine dependence was inhibited by phosphodiesterase (PDE) 4 inhibitors rolipram and diazepam, since a role for the cyclic AMP systems in the development of morphine dependence was reported."3.74Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heart. ( González-Cuello, A; Hernández, J; Laorden, ML; Sánchez, L; Teresa Castells, M; Victoria Milanés, M, 2007)
"Naloxone was injected (5 mg/kg, s."1.31Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice. ( Hosseinzadeh, H; Mojtahedi, K; Ramezani, M, 2001)
"Diazepam (0."1.29Inhibition of morphine tolerance and dependence by diazepam and its relation to cyclic AMP levels in discrete rat brain regions and spinal cord. ( Santosa, DN; Sheu, MJ; Sribanditmongkol, P; Tejwani, GA, 1995)
"7 mg/kg/day), on the gradedly increased dosage schedule with a dosage level of 0."1.27[Physical dependence liability test of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) in rats]. ( Imamaki, H; Ogawa, K; Suzuki, T; Yanaura, S; Yoshii, T, 1987)
"Diazepam was ineffective in the analgesic test and it did not alter morphine analgesia, except when administered in a high dose which decreased and analgesic response."1.26Effects of glycine, beta-alanine and diazepam upon morphine-tolerant-dependent mice. ( Contreras, E; Tamayo, L, 1980)
"Thrombocytosis was not related to withdrawal symptoms or treatment (phenobarbital or paregoric)."1.26Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users. ( Burstein, Y; Giardina, PJ; Kandall, SR; Peterson, CM; Rausen, AR; Siljestrom, K, 1979)
" Physical dependence on phenobarbital and diazepam was produced using the same dosage schedules as with morphine."1.25Physical dependence on morphine, phenobarbital and diazepam in rats by drug-admixed food ingestion. ( Suzuki, T; Tagashira, E; Yanaura, S, 1975)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-199019 (79.17)18.7374
1990's2 (8.33)18.2507
2000's2 (8.33)29.6817
2010's0 (0.00)24.3611
2020's1 (4.17)2.80

Authors

AuthorsStudies
Konstantinopolsky, MA1
Chernyakova, IV1
Kolik, LG1
González-Cuello, A1
Sánchez, L1
Hernández, J1
Teresa Castells, M1
Victoria Milanés, M1
Laorden, ML1
Contreras, E1
Tamayo, L1
Yoshimura, K2
Horiuchi, M1
Inoue, Y1
Yamamoto, K2
Ryser, PE1
Eisenberg, RM2
Wiechman, BE1
Spratto, GR1
Sheu, MJ1
Sribanditmongkol, P1
Santosa, DN1
Tejwani, GA1
Suzuki, T3
Tsuda, M1
Narita, M1
Funada, M1
Mizoguchi, H1
Misawa, M1
Ramezani, M1
Hosseinzadeh, H1
Mojtahedi, K1
Baldino, F1
Cowan, A1
Geller, EB1
Adler, MW1
Burstein, Y1
Giardina, PJ1
Rausen, AR1
Kandall, SR1
Siljestrom, K1
Peterson, CM1
Killam, KF1
Brocco, MJ1
Robinson, CA1
Yanaura, S3
Tagashire, E1
Tagashira, E1
Gibert-Rahola, J1
Maldonado, R1
Micó, JA1
Leonsegui, I1
Saavedra, MC1
Imamaki, H1
Yoshii, T1
Ogawa, K1
Antonelli, T1
Beani, L1
Bianchi, C1
Rando, S1
Simonato, M1
Tanganelli, S1
Kreuzer, A1
Kamei, C1
Shimomura, K1
Ueki, S1
Leuner, H1
Nathenson, G1
Cohen, MI1
Litt, IF1
McNamara, H1

Other Studies

24 other studies available for diazepam and Morphine Dependence

ArticleYear
Selank, a Peptide Analog of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats.
    Bulletin of experimental biology and medicine, 2022, Volume: 173, Issue:6

    Topics: Animals; Diazepam; Morphine; Morphine Dependence; Naloxone; Rats; Substance Withdrawal Syndrome; Tuf

2022
Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heart.
    European journal of pharmacology, 2007, Sep-10, Volume: 570, Issue:1-3

    Topics: Animals; Cyclic AMP; Cyclic GMP; Diazepam; Male; Morphine Dependence; Myocardium; Norepinephrine; No

2007
Effects of glycine, beta-alanine and diazepam upon morphine-tolerant-dependent mice.
    The Journal of pharmacy and pharmacology, 1980, Volume: 32, Issue:5

    Topics: Alanine; Analgesia; Animals; beta-Alanine; Diazepam; Drug Interactions; Drug Tolerance; Female; Glyc

1980
[Pharmacological studies on drug dependence. (III): Intravenous self-administration of some CNS-affecting drugs and a new sleep-inducer, 1H-1, 2, 4-triazolyl benzophenone derivative (450191-S), in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1984, Volume: 83, Issue:1

    Topics: Animals; Central Nervous System Agents; Cocaine; Diazepam; Humans; Hypnotics and Sedatives; Injectio

1984
Sex differences in substance abuse: 1976-1979.
    The International journal of the addictions, 1983, Volume: 18, Issue:1

    Topics: Alcohol Drinking; Diazepam; Female; Heroin Dependence; Humans; Illicit Drugs; Male; Morphine Depende

1983
Further studies on the acute dependence produced by morphine in opiate naive rats.
    Life sciences, 1982, Oct-11, Volume: 31, Issue:15

    Topics: Amphetamine; Animals; Corticosterone; Diazepam; Drug Tolerance; Humans; Male; Morphine; Morphine Dep

1982
Body temperature response to cocaine and diazepam in morphine-treated rats.
    Pharmacology, 1982, Volume: 25, Issue:6

    Topics: Animals; Body Temperature; Cocaine; Diazepam; Drug Interactions; Humans; Male; Morphine; Morphine De

1982
[Neuropharmacological studies on drug dependence (II). Changes in spontaneous motor activity, EEG and brain monoamines during the period of dependence development and of abrupt withdrawal in rats, with special reference to circadian rhythm (author's trans
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1980, Volume: 76, Issue:5

    Topics: Animals; Biogenic Amines; Brain; Circadian Rhythm; Cocaine; Diazepam; Electroencephalography; Humans

1980
Inhibition of morphine tolerance and dependence by diazepam and its relation to cyclic AMP levels in discrete rat brain regions and spinal cord.
    Brain research, 1995, Mar-27, Volume: 675, Issue:1-2

    Topics: Animals; Behavior, Animal; Brain Chemistry; Cerebral Cortex; Cyclic AMP; Diazepam; Drug Implants; Dr

1995
Diazepam pretreatment suppresses morphine withdrawal signs in the mouse.
    Life sciences, 1996, Volume: 58, Issue:4

    Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Anti-Anxiety Agents; Anticonvulsants; Cerebr

1996
Effects of Ferula gummosa Boiss. fractions on morphine dependence in mice.
    Journal of ethnopharmacology, 2001, Volume: 77, Issue:1

    Topics: Administration, Cutaneous; Animals; Diazepam; Ferula; Hypnotics and Sedatives; Iran; Male; Medicine,

2001
Effects of antipsychotic and antianxiety drugs on the morphine abstinence syndrome in rats.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 208, Issue:1

    Topics: Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Body Weight; Chlordiazepoxide;

1979
Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users.
    The Journal of pediatrics, 1979, Volume: 94, Issue:6

    Topics: Amphetamine; Cocaine; Diazepam; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Infant,

1979
Evaluation of narcotic and narcotic antagonist interactions in primates.
    Annals of the New York Academy of Sciences, 1976, Volume: 281

    Topics: Animals; Cyclazocine; Dextroamphetamine; Diazepam; Drug Interactions; Ethanol; Female; Haplorhini; H

1976
[Dependence on and preference for morphine (II). Comparison among morphine, phenobarbital and diazepam].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1975, Volume: 71, Issue:3

    Topics: Animals; Body Weight; Choice Behavior; Decision Making; Diazepam; Female; Humans; Male; Methods; Mor

1975
Physical dependence on morphine, phenobarbital and diazepam in rats by drug-admixed food ingestion.
    Japanese journal of pharmacology, 1975, Volume: 25, Issue:4

    Topics: Animals; Body Weight; Diazepam; Diet; Feeding Behavior; Female; Humans; Levallorphan; Male; Morphine

1975
Comparative study in mice of flunitrazepam vs. diazepam on morphine withdrawal syndrome.
    Progress in neuro-psychopharmacology & biological psychiatry, 1988, Volume: 12, Issue:6

    Topics: Animals; Behavior, Animal; Diazepam; Flunitrazepam; Male; Mice; Mice, Inbred Strains; Morphine; Morp

1988
[Physical dependence liability test of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) in rats].
    The Journal of toxicological sciences, 1987, Volume: 12, Issue:2

    Topics: Animals; Antidepressive Agents; Barbiturates; Benzhydryl Compounds; Body Weight; Codeine; Diazepam;

1987
Cortical acetylcholine release is increased and gamma-aminobutyric acid outflow is reduced during morphine withdrawal.
    British journal of pharmacology, 1986, Volume: 89, Issue:4

    Topics: Acetylcholine; Animals; Atropine; Cerebral Cortex; Diazepam; Female; gamma-Aminobutyric Acid; Guinea

1986
Effects of chronic treatment with diazepam, phenobarbital, or amphetamine on naloxone-precipitated morphine withdrawal.
    Drug and alcohol dependence, 1985, Volume: 15, Issue:4

    Topics: Amphetamine; Animals; Corticosterone; Diazepam; Male; Mice; Morphine Dependence; Motor Activity; Nal

1985
[Surreptitious acquisition of medical prescriptions. Criminologic studies on drugs and deliquency].
    Medizinische Klinik, 1974, Feb-08, Volume: 69, Issue:6

    Topics: Adolescent; Adult; Central Nervous System Stimulants; Criminology; Deception; Diazepam; Drug and Nar

1974
Significance of withdrawal jumping response in predicting physical dependence in mice.
    Japanese journal of pharmacology, 1973, Volume: 23, Issue:3

    Topics: Amitriptyline; Animals; Atropine; Cannabis; Chlordiazepoxide; Chlorpromazine; Diazepam; Humans; Imip

1973
[Acute psychiatric complications due to drug abuse and their therapy].
    Der Nervenarzt, 1972, Volume: 43, Issue:3

    Topics: Adolescent; Diazepam; Humans; Injections, Intravenous; Levallorphan; Morphine Dependence; Nalorphine

1972
The effect of maternal heroin addiction on neonatal jaundice.
    The Journal of pediatrics, 1972, Volume: 81, Issue:5

    Topics: Animals; Bilirubin; Diazepam; Endoplasmic Reticulum; Female; Glucuronates; Heroin; Hexosyltransferas

1972
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