Page last updated: 2024-10-25

diazepam and Melanoma

diazepam has been researched along with Melanoma in 8 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test."3.76Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010)
"1) activity and melanin synthesis, are induced by diazepam in B16/C3 mouse melanoma cells."3.66Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells. ( Engelhardt, DL; Hsu, KC; Laskin, JD; Matthew, E; Weinstein, IB; Zimmerman, EA, 1981)
"This report is an example of tumor metastasis to the temporomandibular joint and its effect on pain, restriction of jaw movement, and the subsequent inability of the patient to function normally."1.25Myofascial pain dysfunction syndrome involving tumor metastasis. Case report. ( Butler, JH, 1975)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's3 (37.50)18.2507
2000's0 (0.00)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Raza, ML1
Zeeshan, M1
Ahmad, M1
Shaheen, F1
Simjee, SU1
Adam, S1
Vessey, M1
Matthew, E1
Laskin, JD1
Zimmerman, EA1
Weinstein, IB1
Hsu, KC1
Engelhardt, DL1
Sporny, S1
Ortega, F1
Carreras, JL1
Maldonado, A1
Pérez-Castejón, MJ1
Montz, R1
Gorospe, E1
Ruiz, JA1
Nieto, C1
Niles, LP1
Wang, J1
Butler, JH1
Solowey, WE1
Pestka, S1
Spector, S1
Fryer, RI1
Fisher, PB1

Reviews

1 review available for diazepam and Melanoma

ArticleYear
[Diazepam and neoplasms].
    Przeglad lekarski, 1984, Volume: 41, Issue:10

    Topics: Animals; Breast Neoplasms; Cocarcinogenesis; Diazepam; Female; Humans; Leukemia L1210; Liver Neoplas

1984

Other Studies

7 other studies available for diazepam and Melanoma

ArticleYear
Anticonvulsant activity of DNS II fraction in the acute seizure models.
    Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3

    Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre

2010
Diazepam and malignant melanoma.
    Lancet (London, England), 1981, Dec-12, Volume: 2, Issue:8259

    Topics: Adolescent; Adult; Diazepam; Female; Humans; Melanoma; Middle Aged; Skin Neoplasms

1981
Benzodiazepines have high-affinity binding sites and induce melanogenesis in B16/C3 melanoma cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:6

    Topics: Benzodiazepines; Cells, Cultured; Diazepam; Fluorescent Antibody Technique; Kinetics; Melanins; Mela

1981
[Muscle uptake of 18FDG in positron emission tomography].
    Revista espanola de medicina nuclear, 1998, Volume: 17, Issue:2

    Topics: Antineoplastic Agents; Anxiety; Breast Neoplasms; Diazepam; Female; Fluorine Radioisotopes; Fluorode

1998
Diazepam inhibits forskolin-stimulated adenylyl cyclase activity in human tumour cells.
    Pharmacology & toxicology, 1999, Volume: 85, Issue:4

    Topics: Adenylyl Cyclase Inhibitors; Anti-Anxiety Agents; Breast Neoplasms; Cell Membrane; Colforsin; Diazep

1999
Myofascial pain dysfunction syndrome involving tumor metastasis. Case report.
    Journal of periodontology, 1975, Volume: 46, Issue:5

    Topics: Breast Neoplasms; Diagnosis, Differential; Diazepam; Facial Muscles; Female; Humans; Mandibular Neop

1975
Peripheral-acting benzodiazepines inhibit the growth of human melanoma cells and potentiate the antiproliferative activity of recombinant human interferons.
    Journal of interferon research, 1990, Volume: 10, Issue:3

    Topics: Antineoplastic Agents; Benzodiazepines; Cell Division; Diazepam; Drug Synergism; Humans; Interferon

1990