diazepam has been researched along with Liver Dysfunction in 30 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report a case of prolonged coma (7 days) which arose as a complication of the treatment of alcohol withdrawal seizures and delirium with intravenous phenobarbital and diazepam." | 7.67 | Reduction of diazepam serum half life and reversal of coma by activated charcoal in a patient with severe liver disease. ( Haug, MT; Traeger, SM, 1986) |
| "A combined cholestatic-hepatocellular injury and noncaseating granulomas occurred in two patients 1 and 4 weeks after phenylbutazone therapy." | 7.65 | Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases. ( Dhar, JK; Ishak, KG; Kirchner, JP, 1977) |
| "We report a case of prolonged coma (7 days) which arose as a complication of the treatment of alcohol withdrawal seizures and delirium with intravenous phenobarbital and diazepam." | 3.67 | Reduction of diazepam serum half life and reversal of coma by activated charcoal in a patient with severe liver disease. ( Haug, MT; Traeger, SM, 1986) |
| "Published data on the effect of cirrhosis on diazepam pharmacokinetics were reanalyzed to determine how age, sex, and body weight might have influenced the conclusions." | 3.66 | Factors influencing diazepam pharmacokinetics: age, sex, and liver disease. ( Greenblatt, DJ; Harmatz, JS; Shader, RI, 1978) |
| "A combined cholestatic-hepatocellular injury and noncaseating granulomas occurred in two patients 1 and 4 weeks after phenylbutazone therapy." | 3.65 | Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases. ( Dhar, JK; Ishak, KG; Kirchner, JP, 1977) |
| "The effects of 5 mg of diazepam intravenously were assessed in 23 patients with liver disease, 10 of whom had clinical evidence either in the past or at the time of study of hepatic encephalopathy." | 3.65 | Clinical and electroencephalographic assessment of diazepam in liver disease. ( Knill-Jones, RP; Murray-Lyon, IM; Parkes, JD; Williams, R; Young, J, 1971) |
| " The accumulation of DD after multiple dosage could be explained by the fact that it is formed faster from D than it is eliminated." | 2.64 | Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease. ( Antonin, KH; Bieck, PR; Brügel, H; Klotz, U, 1977) |
| "Definitions of Delirium Tremens (DT) and related clinical states are discussed together with the concepts of aetiology and pathogenesis in relation to psychiatric disease." | 2.36 | Delirium tremens and related clinical states. Aetiology, pathophysiology and treatment. ( Hemmingsen, R; Kramp, P; Rafaelsen, OJ, 1979) |
| "Anticonvulsant therapy was among the first areas to benefit from clinical pharmacokinetic studies." | 2.35 | Clinical pharmacokinetics of anticonvulsants. ( Dam, M; Hvidberg, EF, 1976) |
| " Animals pretreated with this hepatotoxic agent showed a significant prolongation in the half-life of diazepam in plasma that is due more to an increase in volume of distribution rather than to a decrease in clearance." | 1.28 | Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury. ( Díaz-García, JM; Fos-Galve, D; Oliver-Botana, J, 1992) |
| " Despite the profound prolongation of t 1/2 (theta) with age, the constancy of diazepam clearance indicates that drug plasma concentrations will not accumulate any more in the old than the young, and chronic dosage more in the old than the young, and chronic dosage modifications based on pharmacokinetic considerations are unnecessary." | 1.25 | The effects of age and liver disease on the disposition and elimination of diazepam in adult man. ( Avant, GR; Hoyumpa, A; Klotz, U; Schenker, S; Wilkinson, GR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (83.33) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Siegers, CP | 1 |
| Klaassen, CD | 1 |
| Cebula, TA | 1 |
| El-Hage, AN | 1 |
| Ferrans, VJ | 1 |
| Kolenda, KD | 1 |
| McConnell, JB | 1 |
| Curry, SH | 1 |
| Davis, M | 1 |
| Williams, R | 3 |
| Horwitz, D | 1 |
| Bozkurt, P | 1 |
| Kaya, G | 1 |
| Süzer, O | 1 |
| Sentürk, H | 1 |
| Chatterjee, S | 1 |
| Chatterjee, J | 1 |
| Chaudhuri, K | 1 |
| Basu, S | 1 |
| Maiti, C | 1 |
| Hoyumpa, AM | 2 |
| Schenker, S | 4 |
| Wilkinson, GR | 4 |
| Hemmingsen, R | 1 |
| Kramp, P | 1 |
| Rafaelsen, OJ | 1 |
| Paumgartner, G | 1 |
| Klotz, U | 2 |
| Antonin, KH | 1 |
| Brügel, H | 1 |
| Bieck, PR | 1 |
| Greenblatt, DJ | 1 |
| Harmatz, JS | 1 |
| Shader, RI | 1 |
| Hvidberg, EF | 2 |
| Dam, M | 1 |
| Hendel, J | 1 |
| Elsass, P | 1 |
| Andreasen, PB | 1 |
| Gymoese, E | 1 |
| Ishak, KG | 1 |
| Kirchner, JP | 1 |
| Dhar, JK | 1 |
| Hepner, GW | 1 |
| Vesell, ES | 1 |
| Lipton, A | 1 |
| Harvey, HA | 1 |
| Branch, RA | 1 |
| Morgan, MH | 1 |
| James, J | 1 |
| Read, AE | 1 |
| Avant, GR | 1 |
| Hoyumpa, A | 1 |
| Díaz-García, JM | 1 |
| Oliver-Botana, J | 1 |
| Fos-Galve, D | 1 |
| Lin, TH | 1 |
| Lin, JH | 1 |
| Traeger, SM | 1 |
| Haug, MT | 1 |
| Akdamar, K | 1 |
| Lilly, JO | 1 |
| Mary, CC | 1 |
| Maumus, L | 1 |
| Murray-Lyon, IM | 1 |
| Young, J | 1 |
| Parkes, JD | 1 |
| Knill-Jones, RP | 1 |
| Cunningham, ML | 1 |
6 reviews available for diazepam and Liver Dysfunction
| Article | Year |
|---|---|
[The importance of the biliary excretion of drugs in the human].
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Bile; Biological Transport; Cardiac Glycosides; Contra | 1983 |
[Drug catabolism and its significance for pharmacotherapy].
Topics: Biotransformation; Cytochrome P-450 Enzyme System; Diazepam; Digitoxin; Digoxin; Drug Interactions; | 1980 |
Delirium tremens and related clinical states. Aetiology, pathophysiology and treatment.
Topics: Adrenal Insufficiency; Alcohol Withdrawal Delirium; Animals; Antipsychotic Agents; Avitaminosis; Bar | 1979 |
The effect of parenchymal liver disease on the disposition and elimination of sedatives and analgesics.
Topics: Analgesics; Anti-Anxiety Agents; Barbiturates; Diazepam; Half-Life; Hepatitis; Humans; Hypnotics and | 1975 |
Clinical pharmacokinetics of anticonvulsants.
Topics: Administration, Oral; Adult; Aged; Aging; Animals; Anticonvulsants; Carbamazepine; Child; Clonazepam | 1976 |
Problems of fulminant hepatic failure.
Topics: Acute Disease; Adrenal Cortex Hormones; Amylases; Brain Diseases; Brain Stem; Diazepam; Dihydroxyphe | 1972 |
2 trials available for diazepam and Liver Dysfunction
| Article | Year |
|---|---|
Diazepam serum concentration-sedative effect relationship in patients with liver disease.
Topics: Adjuvants, Anesthesia; Adult; Aged; Blood Pressure; Diazepam; Dose-Response Relationship, Drug; Fema | 1996 |
Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease.
Topics: Adult; Biological Availability; Biotransformation; Clinical Trials as Topic; Diazepam; Half-Life; He | 1977 |
22 other studies available for diazepam and Liver Dysfunction
| Article | Year |
|---|---|
Choice of benzodiazepines.
Topics: Aged; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Diazepam; Flurazepam; Half-Life; Humans; Liver | 1981 |
Toxic interactions of benzyl alcohol with bacterial endotoxin.
Topics: Animals; Benzyl Alcohol; Benzyl Alcohols; Benzyl Compounds; Blood Chemical Analysis; Chemical and Dr | 1984 |
Clinical effects and metabolism of diazepam in patients with chronic liver disease.
Topics: Adult; Behavior; Chronic Disease; Diazepam; Humans; Liver Cirrhosis; Liver Diseases; Middle Aged; Ps | 1982 |
Adverse reactions to diazepam.
Topics: Animals; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; Diazepam; Liver; Liver Diseases | 1994 |
Hepatotoxicity of diazepam. Structural and trace metal studies in rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Copper; Diazepam; Iron; Liver; Liver Diseases; Micr | 1997 |
Disposition and elimination of minor tranquilizers in the aged and in patients with liver disease.
Topics: Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hepatitis; Humans; Liver Cirrhosis; Li | 1978 |
Effects of liver disease and of aging on the disposition and elimination of sedatives.
Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral, | 1978 |
The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man.
Topics: Administration, Oral; Adult; Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Female; H | 1978 |
[Drug metabolism in liver diseases].
Topics: Antipyrine; Biological Availability; Biotransformation; Diazepam; Humans; Liver; Liver Diseases; Pha | 1979 |
Factors influencing diazepam pharmacokinetics: age, sex, and liver disease.
Topics: Adult; Aged; Aging; Body Weight; Diazepam; Female; Galactose; Humans; Kinetics; Liver Diseases; Male | 1978 |
Neuropsychologic effects of diazepam related to single dose kinetics and liver function.
Topics: Diazepam; Emotions; Evoked Potentials; Galvanic Skin Response; Heart Rate; Humans; Kinetics; Liver D | 1976 |
Sedation in liver disease.
Topics: Diazepam; Humans; Hypnotics and Sedatives; Liver Diseases | 1977 |
Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases.
Topics: Aged; Chemical and Drug Induced Liver Injury; Chlordiazepoxide; Cholestasis; Diazepam; Granuloma; Hu | 1977 |
Disposition of aminopyrine, antipyrine, diazepam, and indocyanine green in patients with liver disease or on anticonvulsant drug therapy: diazepam breath test and correlations in drug elimination.
Topics: Adult; Aged; Aminopyrine; Anticonvulsants; Antipyrine; Breath Tests; Diazepam; Half-Life; Humans; In | 1977 |
Intravenous administration of diazepam in patients with chronic liver disease.
Topics: Chronic Disease; Diazepam; Dose-Response Relationship, Drug; Electroencephalography; Humans; Injecti | 1976 |
The effects of age and liver disease on the disposition and elimination of diazepam in adult man.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Aging; Alcoholism; Animals; Diazepam; Fe | 1975 |
Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Proteins; Ca | 1992 |
Effects of protein binding and experimental disease states on brain uptake of benzodiazepines in rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Blood-Brain Barrier; Brain; Devaze | 1990 |
Reduction of diazepam serum half life and reversal of coma by activated charcoal in a patient with severe liver disease.
Topics: Administration, Oral; Charcoal; Coma; Diazepam; Female; Half-Life; Humans; Liver Diseases; Middle Ag | 1986 |
Peritoneoscopy facilitated by premedication with diazepam.
Topics: Adult; Aged; Diazepam; Female; Humans; Laparoscopy; Liver Diseases; Male; Middle Aged; Premedication | 1971 |
Clinical and electroencephalographic assessment of diazepam in liver disease.
Topics: Alcoholism; Budd-Chiari Syndrome; Cholestasis; Chronic Disease; Consciousness; Diazepam; Electroence | 1971 |
Acute hepatic necrosis following treatment with amitriptyline and diazepam.
Topics: Amitriptyline; Depression; Diazepam; Female; Humans; Liver Diseases; Middle Aged | 1965 |