diazepam has been researched along with Lesch-Nyhan Syndrome in 2 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Robey, KL | 1 |
| Reck, JF | 1 |
| Giacomini, KD | 1 |
| Barabas, G | 1 |
| Eddey, GE | 1 |
| Larson, LO | 1 |
| Wilkins, RG | 1 |
2 other studies available for diazepam and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
Modes and patterns of self-mutilation in persons with Lesch-Nyhan disease.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Chromosomes, Human, X; D | 2003 |
Anesthesia and the Lesch-Nyhan syndrome.
Topics: Adult; Anesthesia, General; Atracurium; Diazepam; Humans; Intubation, Intratracheal; Isoflurane; Iso | 1985 |