diazepam has been researched along with Inflammation in 25 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazepam could regulate immune system and inflammation, which might be a potential therapeutic agent for pulmonary fibrosis in clinic." | 7.91 | Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABA ( Bo, F; Deng, M; Li, Y; Song, D; Tang, X, 2019) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 7.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "0 mg kg-1 day-1, for 21 days) diazepam treatment on carrageenin-induced paw edema were studied in rats." | 7.69 | Effects of high doses of diazepam on carrageenin-induced paw edema in rats. ( Lazzarini, R; Malucelli, BE; Palermo-Neto, J; Paulino, CA, 1996) |
| "Nerve inflammation is linked to the development of various neurological disorders." | 5.91 | Glycyrrhizae Radix suppresses lipopolysaccharide- and diazepam-induced nerve inflammation in the hippocampus, and contracts the duration of pentobarbital- induced loss of righting reflex in a mouse model. ( Ishida, T; Jobu, K; Kawada, K; Miyamura, M; Morisawa, S; Nishida, M; Tamura, N; Yoshioka, S, 2023) |
| "Neuroinflammation is associated with the development of hypoactive delirium, which results in poor clinical outcomes." | 5.72 | Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital. ( Ishida, T; Jobu, K; Kawada, K; Kawazoe, T; Miyamura, M; Morisawa, S; Nishida, M; Nishimura, S; Tamura, N; Yoshioka, S, 2022) |
| "Treatment with diazepam inhibited the previously described reduction in glutamate release in the frontal cortex synaptosomes from EAE animals." | 5.37 | Inhibitory role of diazepam on autoimmune inflammation in rats with experimental autoimmune encephalomyelitis. ( Báez, NS; Bibolini, MJ; Chanaday, NL; Degano, AL; Monferran, CG; Roth, GA, 2011) |
| "diazepam treatment reduced the magnitude of the increase in vascular permeability caused by carrageenin; 5." | 5.31 | Reduction of acute inflammation in rats by diazepam: role of peripheral benzodiazepine receptors and corticosterone. ( Lazzarini, R; Malucelli, BE; Palermo-Neto, J, 2001) |
| "Diazepam could regulate immune system and inflammation, which might be a potential therapeutic agent for pulmonary fibrosis in clinic." | 3.91 | Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABA ( Bo, F; Deng, M; Li, Y; Song, D; Tang, X, 2019) |
| "In the nociception test, the pain-induced functional impairment rat model, uric acid at 3." | 3.73 | Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats. ( Fernández-Guasti, A; López-Muñoz, FJ; Martínez-Mota, L; Reyes, R, 2005) |
| "Pulmonary inflammation induced in the rabbit lung by the intravenous injection of complete Freund's adjuvant (CFA) increases the lung uptake of 14C-diazepam from the pulmonary circulation." | 3.71 | Lung tissue mitochondrial benzodiazepine receptors increase in a model of pulmonary inflammation. ( Ahlf, SB; Audi, SH; Dawson, CA; Roerig, DL, 2002) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 3.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "0 mg kg-1 day-1, for 21 days) diazepam treatment on carrageenin-induced paw edema were studied in rats." | 3.69 | Effects of high doses of diazepam on carrageenin-induced paw edema in rats. ( Lazzarini, R; Malucelli, BE; Palermo-Neto, J; Paulino, CA, 1996) |
| "Further, large areas of mechanical hyperalgesia to pinprick adjacent to the erythema spots developed in all subjects." | 2.71 | The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers. ( Felouzis, E; Gustorff, B; Hoechtl, K; Kress, HG; Lehr, S; Sycha, T, 2004) |
| "Nerve inflammation is linked to the development of various neurological disorders." | 1.91 | Glycyrrhizae Radix suppresses lipopolysaccharide- and diazepam-induced nerve inflammation in the hippocampus, and contracts the duration of pentobarbital- induced loss of righting reflex in a mouse model. ( Ishida, T; Jobu, K; Kawada, K; Miyamura, M; Morisawa, S; Nishida, M; Tamura, N; Yoshioka, S, 2023) |
| "Neuroinflammation is associated with the development of hypoactive delirium, which results in poor clinical outcomes." | 1.72 | Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital. ( Ishida, T; Jobu, K; Kawada, K; Kawazoe, T; Miyamura, M; Morisawa, S; Nishida, M; Nishimura, S; Tamura, N; Yoshioka, S, 2022) |
| "CD-1 mice were dosed with Bacille Calmette-Guérin (BCG) and measures of body weight, locomotor activity, and immobility in the tail suspension test (TST) were made." | 1.39 | A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants. ( Clark, JA; Klee, N; Nizami, M; Platt, B; Schulenberg, J, 2013) |
| "CFA-induced mechanical allodynia resulted in increased anxiety-like behaviors as evidenced by: (1) a significant decrease in percentage of time spent and number of entries in open arms of the elevated-plus maze (EPM), (2) a decrease in number of central squares visited in the open field (OF), and (3) a reduction in active social interactions in the social interaction test (SI)." | 1.38 | Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain. ( Beaudet, N; Beaudry, H; Bergeron, J; Bérubé, P; Drolet, G; Gendron, L; Parent, AJ; Sarret, P, 2012) |
| "Treatment with diazepam inhibited the previously described reduction in glutamate release in the frontal cortex synaptosomes from EAE animals." | 1.37 | Inhibitory role of diazepam on autoimmune inflammation in rats with experimental autoimmune encephalomyelitis. ( Báez, NS; Bibolini, MJ; Chanaday, NL; Degano, AL; Monferran, CG; Roth, GA, 2011) |
| "diazepam treatment reduced the magnitude of the increase in vascular permeability caused by carrageenin; 5." | 1.31 | Reduction of acute inflammation in rats by diazepam: role of peripheral benzodiazepine receptors and corticosterone. ( Lazzarini, R; Malucelli, BE; Palermo-Neto, J, 2001) |
| " The relative oral/intramuscular bioavailability of amitriptyline was only 13%, and the steady-state concentrations of this drug on four consecutive days were acutely subtherapeutic (i." | 1.27 | Decreased drug absorption in a patient with Behçet's syndrome. ( Atiyeh, M; Chaleby, K; el-Yazigi, A, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 8 (32.00) | 29.6817 |
| 2010's | 7 (28.00) | 24.3611 |
| 2020's | 4 (16.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kawada, K | 2 |
| Ishida, T | 2 |
| Jobu, K | 2 |
| Morisawa, S | 2 |
| Kawazoe, T | 1 |
| Nishida, M | 2 |
| Nishimura, S | 1 |
| Tamura, N | 2 |
| Yoshioka, S | 2 |
| Miyamura, M | 2 |
| Regner, GG | 1 |
| Torres, ILS | 1 |
| de Oliveira, C | 1 |
| Pflüger, P | 1 |
| da Silva, LS | 1 |
| Scarabelot, VL | 1 |
| Ströher, R | 1 |
| de Souza, A | 1 |
| Fregni, F | 1 |
| Pereira, P | 1 |
| Matsumoto, D | 1 |
| Ushio, S | 1 |
| Wada, Y | 1 |
| Noda, Y | 1 |
| Esumi, S | 1 |
| Izushi, Y | 1 |
| Kitamura, Y | 1 |
| Sendo, T | 1 |
| Li, Y | 1 |
| Song, D | 1 |
| Bo, F | 1 |
| Deng, M | 1 |
| Tang, X | 1 |
| MacRae, M | 1 |
| Kenkel, WM | 1 |
| Kentner, AC | 1 |
| Gould, SA | 1 |
| Doods, H | 1 |
| Lamla, T | 1 |
| Pekcec, A | 1 |
| Munro, G | 1 |
| Lopez-Garcia, JA | 1 |
| Rivera-Arconada, I | 1 |
| Erichsen, HK | 1 |
| Nielsen, EØ | 1 |
| Larsen, JS | 1 |
| Ahring, PK | 1 |
| Mirza, NR | 1 |
| Lazzarini, R | 4 |
| Sakai, M | 1 |
| Costa-Pinto, FA | 1 |
| Palermo-Neto, J | 4 |
| Bibolini, MJ | 1 |
| Chanaday, NL | 1 |
| Báez, NS | 1 |
| Degano, AL | 1 |
| Monferran, CG | 1 |
| Roth, GA | 1 |
| Parent, AJ | 1 |
| Beaudet, N | 1 |
| Beaudry, H | 1 |
| Bergeron, J | 1 |
| Bérubé, P | 1 |
| Drolet, G | 1 |
| Sarret, P | 1 |
| Gendron, L | 1 |
| Platt, B | 1 |
| Schulenberg, J | 1 |
| Klee, N | 1 |
| Nizami, M | 1 |
| Clark, JA | 1 |
| Audi, SH | 1 |
| Dawson, CA | 1 |
| Ahlf, SB | 1 |
| Roerig, DL | 1 |
| Gustorff, B | 1 |
| Hoechtl, K | 1 |
| Sycha, T | 1 |
| Felouzis, E | 1 |
| Lehr, S | 1 |
| Kress, HG | 1 |
| Fernández-Guasti, A | 1 |
| Reyes, R | 1 |
| Martínez-Mota, L | 1 |
| López-Muñoz, FJ | 1 |
| Maiorka, PC | 1 |
| Liu, J | 1 |
| Papadopoulos, V | 1 |
| Knabl, J | 1 |
| Witschi, R | 1 |
| Hösl, K | 1 |
| Reinold, H | 1 |
| Zeilhofer, UB | 1 |
| Ahmadi, S | 1 |
| Brockhaus, J | 1 |
| Sergejeva, M | 1 |
| Hess, A | 1 |
| Brune, K | 1 |
| Fritschy, JM | 1 |
| Rudolph, U | 1 |
| Möhler, H | 1 |
| Zeilhofer, HU | 1 |
| Rahman, AF | 1 |
| Takahashi, M | 1 |
| Kaneto, H | 1 |
| Paulino, CA | 1 |
| Malucelli, BE | 2 |
| Mediratta, PK | 1 |
| Sharma, KK | 1 |
| Singh, S | 1 |
| Belpaire, FM | 1 |
| De Rick, A | 1 |
| Dello, C | 1 |
| Fraeyman, N | 1 |
| Bogaert, MG | 1 |
| Chaleby, K | 1 |
| el-Yazigi, A | 1 |
| Atiyeh, M | 1 |
| Paparella, MM | 1 |
| Jaques, R | 1 |
| Riesterer, L | 1 |
1 trial available for diazepam and Inflammation
| Article | Year |
|---|---|
The effects of remifentanil and gabapentin on hyperalgesia in a new extended inflammatory skin pain model in healthy volunteers.
Topics: Acetates; Adult; Amines; Analgesics, Opioid; Cross-Over Studies; Cyclohexanecarboxylic Acids; Diazep | 2004 |
24 other studies available for diazepam and Inflammation
| Article | Year |
|---|---|
Yokukansan suppresses neuroinflammation in the hippocampus of mice and decreases the duration of lipopolysaccharide- and diazepam-mediated loss of righting reflex induced by pentobarbital.
Topics: Animals; Delirium; Diazepam; Drugs, Chinese Herbal; Glycyrrhizic Acid; Hippocampus; Inflammation; In | 2022 |
Glycyrrhizae Radix suppresses lipopolysaccharide- and diazepam-induced nerve inflammation in the hippocampus, and contracts the duration of pentobarbital- induced loss of righting reflex in a mouse model.
Topics: Animals; Diazepam; Drugs, Chinese Herbal; Glycyrrhiza; Glycyrrhizic Acid; Hippocampus; Inflammation; | 2023 |
Transcranial direct current stimulation (tDCS) affects neuroinflammation parameters and behavioral seizure activity in pentylenetetrazole-induced kindling in rats.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Inflammation; Kindling, Neurologic; Male; Pe | 2020 |
Bumetanide prevents diazepam-modified anxiety-like behavior in lipopolysaccharide-treated mice.
Topics: Animals; Anti-Anxiety Agents; Anti-Bacterial Agents; Anxiety; Behavior, Animal; Bicuculline; Bumetan | 2021 |
Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABA
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Diazepam; Disease Models, Animal; Humans; Inf | 2019 |
Social rejection following neonatal inflammation is mediated by olfactory scent cues.
Topics: Administration, Intranasal; Animals; Animals, Newborn; Anti-Anxiety Agents; Behavior, Animal; Cues; | 2015 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D | 2016 |
Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory
Topics: Allosteric Regulation; Animals; Benzimidazoles; Benzodiazepinones; Diazepam; GABA Modulators; Humans | 2008 |
Diazepam decreases leukocyte-endothelium interactions in situ.
Topics: Animals; Arginine; Carrageenan; Diazepam; Endothelium, Vascular; Inflammation; Leukocyte Rolling; Le | 2010 |
Inhibitory role of diazepam on autoimmune inflammation in rats with experimental autoimmune encephalomyelitis.
Topics: Animals; Autoimmunity; Diazepam; Encephalomyelitis, Autoimmune, Experimental; GABA Agonists; Inflamm | 2011 |
Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Chronic Disease; Dark Adaptation; Diaze | 2012 |
A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants.
Topics: Animals; Antidepressive Agents; BCG Vaccine; Chronic Disease; Depression; Desipramine; Diazepam; Dis | 2013 |
Lung tissue mitochondrial benzodiazepine receptors increase in a model of pulmonary inflammation.
Topics: Animals; Carbon Radioisotopes; Caspase 3; Caspases; Diazepam; Enzyme Precursors; Female; Freund's Ad | 2002 |
Influence of inflammatory nociception on the anxiolytic-like effect of diazepam and buspirone in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Aspirin; Behavior, Animal; Buspirone; D | 2005 |
Diazepam effects on carrageenan-induced inflammatory paw edema in rats: role of nitric oxide.
Topics: Animals; Anti-Inflammatory Agents; Arginine; Carrageenan; Diazepam; Edema; Hypnotics and Sedatives; | 2006 |
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Topics: Analgesics; Animals; Brain; Capsaicin; Chronic Disease; Diazepam; Disease Models, Animal; Fluorobenz | 2008 |
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm | 1994 |
Effects of high doses of diazepam on carrageenin-induced paw edema in rats.
Topics: Animals; Carrageenan; Diazepam; Dose-Response Relationship, Drug; Edema; Extremities; GABA Modulator | 1996 |
Reduction of acute inflammation in rats by diazepam: role of peripheral benzodiazepine receptors and corticosterone.
Topics: Acute Disease; Adrenalectomy; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodiazepinones; C | 2001 |
Evaluation of immunomodulatory potential of Ocimum sanctum seed oil and its possible mechanism of action.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Diazepam; Erythrocytes; Flumazenil; Foot; GABA | 2002 |
Alpha 1-acid glycoprotein and serum binding of drugs in healthy and diseased dogs.
Topics: Animals; Blood Sedimentation; Diazepam; Digitoxin; Dog Diseases; Dogs; Female; Inflammation; Lidocai | 1987 |
Decreased drug absorption in a patient with Behçet's syndrome.
Topics: Acetaminophen; Adult; Amitriptyline; Behcet Syndrome; Biological Availability; Diazepam; Female; Hum | 1987 |
The dizzy patient.
Topics: Diazepam; Drainage; Ear; Ear Neoplasms; Ethacrynic Acid; Gentamicins; Hearing Disorders; Humans; Inf | 1972 |
The influence of psychopharmacologically active substances on various models of an inflammatory reaction.
Topics: Animals; Anthracenes; Arthritis; Carrageenan; Chlorpromazine; Diazepam; Edema; Foot; Hindlimb; Infla | 1971 |