diazepam has been researched along with Harelip in 13 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Key words were diazepam or benzodiazepine(s) combined with cleft lip, cleft palate, oral malformations, prenatal exposure, GABA, gene expression and extracellular matrix." | 8.87 | Diazepam effects on non-syndromic cleft lip with or without palate: epidemiological studies, clinical findings, genes and extracellular matrix. ( Balloni, S; Bodo, M; Carinci, F; Locci, P; Marinucci, L; Pezzetti, F, 2011) |
| "The hypothesis that in utero exposure to diazepam increases the risk of oral-cleft anomalies was evaluated in a case-control study, in which 445 infants with cleft lip with or without cleft palate and 166 with cleft palate without cleft lip (cleft palate alone) were compared with 2498 control infants having other birth defects." | 7.66 | Lack of relation of oral clefts to diazepam use during pregnancy. ( Louik, C; Mitchell, AA; Parsells, JL; Pashayan, H; Rosenberg, L; Shapiro, S, 1983) |
| " The mother took clonidine during pregnancy." | 7.66 | Roberts's syndrome and clonidine. ( Beshara, D; Levy, JM; Stoll, C, 1979) |
| "From 278 interviews of women who had infants with selected major malformations, a history of diazepam ingestion in the first trimester of pregnancy was found to be four times more frequent among mothers of children with a cleft lip with or without a cleft palate than among mothers of children with other defects." | 7.65 | Association between cleft lip with or without cleft palate and prenatal exposure to diazepam. ( Oakley, GP; Safra, MJ, 1975) |
| " Key words were diazepam or benzodiazepine(s) combined with cleft lip, cleft palate, oral malformations, prenatal exposure, GABA, gene expression and extracellular matrix." | 4.87 | Diazepam effects on non-syndromic cleft lip with or without palate: epidemiological studies, clinical findings, genes and extracellular matrix. ( Balloni, S; Bodo, M; Carinci, F; Locci, P; Marinucci, L; Pezzetti, F, 2011) |
| "The hypothesis that in utero exposure to diazepam increases the risk of oral-cleft anomalies was evaluated in a case-control study, in which 445 infants with cleft lip with or without cleft palate and 166 with cleft palate without cleft lip (cleft palate alone) were compared with 2498 control infants having other birth defects." | 3.66 | Lack of relation of oral clefts to diazepam use during pregnancy. ( Louik, C; Mitchell, AA; Parsells, JL; Pashayan, H; Rosenberg, L; Shapiro, S, 1983) |
| " The mother took clonidine during pregnancy." | 3.66 | Roberts's syndrome and clonidine. ( Beshara, D; Levy, JM; Stoll, C, 1979) |
| "From 278 interviews of women who had infants with selected major malformations, a history of diazepam ingestion in the first trimester of pregnancy was found to be four times more frequent among mothers of children with a cleft lip with or without a cleft palate than among mothers of children with other defects." | 3.65 | Association between cleft lip with or without cleft palate and prenatal exposure to diazepam. ( Oakley, GP; Safra, MJ, 1975) |
| " In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida." | 3.65 | A teratological evaluation of anticonvulsant drugs. ( Czeizel, E; Lakos, P, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (84.62) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marinucci, L | 2 |
| Balloni, S | 2 |
| Bodo, M | 2 |
| Carinci, F | 2 |
| Pezzetti, F | 2 |
| Stabellini, G | 1 |
| Conte, C | 1 |
| Carmela, C | 1 |
| Lumare, E | 1 |
| Locci, P | 1 |
| Rosenberg, L | 1 |
| Mitchell, AA | 1 |
| Parsells, JL | 1 |
| Pashayan, H | 1 |
| Louik, C | 1 |
| Shapiro, S | 1 |
| Shader, RI | 1 |
| Greenblatt, DJ | 1 |
| Entman, SS | 1 |
| Vaughn, WK | 1 |
| Safra, MJ | 2 |
| Oakley, GP | 2 |
| Saxén, I | 2 |
| Saxén, L | 1 |
| Czeizel, A | 1 |
| Stoll, C | 1 |
| Levy, JM | 1 |
| Beshara, D | 1 |
| Lakos, P | 1 |
| Czeizel, E | 1 |
| Lunde, I | 1 |
| Brochgrevink, CF | 1 |
1 review available for diazepam and Harelip
| Article | Year |
|---|---|
Diazepam effects on non-syndromic cleft lip with or without palate: epidemiological studies, clinical findings, genes and extracellular matrix.
Topics: Animals; Anti-Anxiety Agents; Cleft Lip; Cleft Palate; Diazepam; Environment; Epidemiologic Studies; | 2011 |
12 other studies available for diazepam and Harelip
| Article | Year |
|---|---|
Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture.
Topics: Anti-Anxiety Agents; Case-Control Studies; Cell Proliferation; Cell Shape; Cells, Cultured; Child; C | 2009 |
Lack of relation of oral clefts to diazepam use during pregnancy.
Topics: Cleft Lip; Cleft Palate; Diazepam; Female; Fetus; Humans; Infant; Infant, Newborn; Interviews as Top | 1983 |
Benzodiazepines during early pregnancy.
Topics: Cleft Lip; Cleft Palate; Diazepam; Humans; Risk | 1984 |
Lack of relation of oral clefts to diazepam use in pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Pre | 1984 |
Association between cleft lip with or without cleft palate and prenatal exposure to diazepam.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Maternal-Fetal Excha | 1975 |
Letter: Association between maternal intake of diazepam and oral clefts.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant; Infant, Newb | 1975 |
Letter: Diazepam, phenytoin, and aetiology of cleft lip and/or cleft palate.
Topics: Anencephaly; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Phenytoin; Pregnanc | 1976 |
Roberts's syndrome and clonidine.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Cleft Lip; Cleft Palate; Clonidine; Diazepam; | 1979 |
A teratological evaluation of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anencephaly; Anticonvulsants; Cleft Lip; Cleft Palate; Diazepam; Epilep | 1977 |
Valium: an oral cleft teratogen?
Topics: Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Teratogens | 1976 |
[Use of diazepam in early pregnancy].
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Pre | 1976 |
Associations between oral clefts and drugs taken during pregnancy.
Topics: Abnormalities, Drug-Induced; Analgesics; Anticonvulsants; Chloramphenicol; Cleft Lip; Cleft Palate; | 1975 |