diazepam has been researched along with Glioma in 20 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells." | 7.71 | Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line. ( Lavicka, J; Mirossay, A; Mirossay, L; Mojzis, J; Sarisský, M; Sulla, I, 2001) |
| "The C6-2B glioma cell line, rich in mitochondrial receptors that bind with high affinity to benzodiazepines, imidazopyridines, and isoquinolinecarboxamides (previously called peripheral-type benzodiazepine receptors), was investigated as a model to study the significance of the polypeptide diazepam binding inhibitor (DBI) and the putative DBI processing products on mitochondrial receptor-regulated steroidogenesis." | 7.68 | Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. ( Costa, E; Guarneri, P; Guidotti, A; Kreuger, KE; Papadopoulos, V, 1992) |
| "Five milligrams of intravenous diazepam given prior to contrast media injection statistically significantly reduced the incidence of contrast media-associated seizures from 16% to 2% in a prospective, randomized series of glioma patients." | 7.67 | Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography. ( Bigelow, RH; Hayman, LA; Lepke, RA; Libshitz, HI; Pagani, JJ, 1984) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 7.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| " In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells." | 3.71 | Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line. ( Lavicka, J; Mirossay, A; Mirossay, L; Mojzis, J; Sarisský, M; Sulla, I, 2001) |
| "The C6-2B glioma cell line, rich in mitochondrial receptors that bind with high affinity to benzodiazepines, imidazopyridines, and isoquinolinecarboxamides (previously called peripheral-type benzodiazepine receptors), was investigated as a model to study the significance of the polypeptide diazepam binding inhibitor (DBI) and the putative DBI processing products on mitochondrial receptor-regulated steroidogenesis." | 3.68 | Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. ( Costa, E; Guarneri, P; Guidotti, A; Kreuger, KE; Papadopoulos, V, 1992) |
| "We have demonstrated high affinity diazepam binding sites of the Ro5-4864 benzodiazepine receptor subtype on 108CC15 neuroblastoma X glioma hybrid cells." | 3.67 | Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells. ( Snell, CR; Snell, PH, 1984) |
| "Five milligrams of intravenous diazepam given prior to contrast media injection statistically significantly reduced the incidence of contrast media-associated seizures from 16% to 2% in a prospective, randomized series of glioma patients." | 3.67 | Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography. ( Bigelow, RH; Hayman, LA; Lepke, RA; Libshitz, HI; Pagani, JJ, 1984) |
| "The benzodiazepines, Ro 5-4864, diazepam, clonazepam, and also PK-11195, inhibited, at micromolar concentrations, the proliferation of rat C6 glioma and mouse neuro-2A neuroblastoma cells in culture." | 3.67 | Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor. ( Gorman, AM; O'Beirne, GB; Regan, CM; Williams, DC, 1989) |
| "The effects of several benzodiazepines (diazepam, clonazepam, Ro 15-1788 and Ro 5-4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay." | 3.67 | Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro. ( Kunert-Radek, J; Pawlikowski, M; Radek, A; Stepien, H, 1988) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 3.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| " dosing was followed by rapid elimination of the drug and was ineffective." | 1.35 | Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand. ( Beaudry, F; Berger, F; Falardeau, P; Farnet, CM; Gourdeau, H; McAlpine, JB; Ranger, M; Simard, B, 2008) |
| "Reported are three patients with ictal monoparesis of an arm." | 1.33 | Ictal monoparesis associated with lesions in the primary somatosensory area. ( Aoki, T; Hanakawa, T; Hitomi, T; Ikeda, A; Matsumoto, R; Miki, Y; Shibasaki, H; Shimohama, S; Tomimoto, H, 2005) |
| "Brief limbic seizures were evoked by intraamygdala kainic acid to elicit unilateral death of target hippocampal CA3 neurons in the rat." | 1.31 | Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures. ( Araki, T; Bonislawski, DP; Henshall, DC; Lan, JQ; Meller, R; Minami, M; Schindler, CK; Simon, RP; Skradski, SL, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (65.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Henshall, DC | 1 |
| Skradski, SL | 1 |
| Meller, R | 1 |
| Araki, T | 1 |
| Minami, M | 1 |
| Schindler, CK | 1 |
| Lan, JQ | 1 |
| Bonislawski, DP | 1 |
| Simon, RP | 1 |
| Matsumoto, R | 1 |
| Ikeda, A | 1 |
| Hitomi, T | 1 |
| Aoki, T | 1 |
| Hanakawa, T | 1 |
| Miki, Y | 1 |
| Tomimoto, H | 1 |
| Shimohama, S | 1 |
| Shibasaki, H | 1 |
| Gourdeau, H | 1 |
| McAlpine, JB | 1 |
| Ranger, M | 1 |
| Simard, B | 1 |
| Berger, F | 1 |
| Beaudry, F | 1 |
| Farnet, CM | 1 |
| Falardeau, P | 1 |
| Snell, CR | 1 |
| Snell, PH | 1 |
| Gallager, DW | 1 |
| Mallorga, P | 1 |
| Oertel, W | 1 |
| Henneberry, R | 1 |
| Tallman, J | 1 |
| Thomas, JW | 1 |
| Tallman, JF | 1 |
| Zlobina, GP | 2 |
| Kondakova, LI | 2 |
| Mukhin, AG | 1 |
| Pagani, JJ | 1 |
| Hayman, LA | 1 |
| Bigelow, RH | 1 |
| Libshitz, HI | 1 |
| Lepke, RA | 1 |
| Khalansky, AS | 1 |
| Ishizawa, Y | 1 |
| Furuya, K | 1 |
| Yamagishi, S | 1 |
| Dohi, S | 1 |
| Oudard, S | 1 |
| Miccoli, L | 1 |
| Dutrillaux, B | 1 |
| Poupon, MF | 1 |
| Lavicka, J | 1 |
| Sarisský, M | 1 |
| Mirossay, A | 1 |
| Sulla, I | 1 |
| Mojzis, J | 1 |
| Mirossay, L | 1 |
| Propst, F | 1 |
| Moroder, L | 1 |
| Wünsch, E | 1 |
| Hamprecht, B | 1 |
| Syapin, PJ | 1 |
| Skolnick, P | 1 |
| Papadopoulos, V | 1 |
| Guarneri, P | 1 |
| Kreuger, KE | 1 |
| Guidotti, A | 1 |
| Costa, E | 1 |
| Gorman, AM | 1 |
| O'Beirne, GB | 1 |
| Regan, CM | 1 |
| Williams, DC | 1 |
| Majewska, MD | 1 |
| Chuang, DM | 1 |
| Pawlikowski, M | 1 |
| Kunert-Radek, J | 1 |
| Radek, A | 1 |
| Stepien, H | 1 |
| Klein, DS | 1 |
| Klein, PW | 1 |
| Mahaley, MS | 1 |
| Tenser, RB | 1 |
| Corbett, JJ | 1 |
1 review available for diazepam and Glioma
| Article | Year |
|---|---|
[Targeting the gene of glucose metabolism for the treatment of advanced gliomas].
Topics: Antineoplastic Agents; Brain; Brain Neoplasms; Chromosome Deletion; Diazepam; Glioma; Glucose; Glyco | 1998 |
19 other studies available for diazepam and Glioma
| Article | Year |
|---|---|
Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
Topics: Amygdala; Animals; Apoptosis; Caspase 6; Caspase 7; Caspases; Convulsants; Diazepam; Electroencephal | 2002 |
Ictal monoparesis associated with lesions in the primary somatosensory area.
Topics: Adult; Arm; Brain Damage, Chronic; Brain Neoplasms; Cerebral Angiography; Cerebral Veins; Diazepam; | 2005 |
Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Benzodiazepines; Brain Neoplasms; Cell Line, Tumor | 2008 |
Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Cells, Cultured; Clonazepam; Cy | 1984 |
[3H]Diazepam binding in mammalian central nervous system: a pharmacological characterization.
Topics: Animals; Binding, Competitive; Cell Line; Cells, Cultured; Cerebral Cortex; Diazepam; Fetus; Fibrobl | 1981 |
Characterization of photoaffinity labeling of benzodiazepine binding sites.
Topics: Affinity Labels; Animals; Benzodiazepines; Brain; Cell Line; Cell Membrane; Cerebral Cortex; Corpus | 1981 |
[Benzodiazepine receptors of the mouse glioblastoma cell line: the anomalous effect of gamma-aminobutyric acid on diazepam binding].
Topics: Animals; Benzodiazepines; Brain Neoplasms; Cell Line; Cells, Cultured; Diazepam; gamma-Aminobutyric | 1982 |
Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography.
Topics: Adolescent; Adult; Brain Neoplasms; Contrast Media; Diazepam; Drug Evaluation; Female; Glioma; Human | 1984 |
Specific binding of [3H]diazepam in mouse glioblastoma: the influence of clonazepam and Ro 5-4864 on [3H]diazepam binding.
Topics: Animals; Benzodiazepinones; Binding Sites; Cell Line; Clonazepam; Diazepam; Glioma; Mice; Neuroglia | 1984 |
Non-GABAergic effects of midazolam, diazepam and flumazenil on voltage-dependent ion currents in NG108-15 cells.
Topics: Animals; Calcium Channels; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyri | 1997 |
Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line.
Topics: Anticonvulsants; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; | 2001 |
The influence of secretin, glucagon and other peptides, of amino acids, prostaglandin endoperoxide analogues and diazepam on the level of adenosine 3',5'-cyclic monophosphate in neuroblastoma x glioma hybrid cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acids; Cyclic AMP | 1979 |
Characterization of benzodiazepine binding sites in cultured cells of neural origin.
Topics: Animals; Astrocytoma; Cell Line; Cell Membrane; Cerebral Cortex; Diazepam; Glioma; Humans; Kinetics; | 1979 |
Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor.
Topics: Animals; Cholesterol Side-Chain Cleavage Enzyme; Diazepam; Diazepam Binding Inhibitor; Glioma; In Vi | 1992 |
Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Blood; Cell Division; Clonazepam; Diazepam; DNA; Glioma | 1989 |
Benzodiazepines enhance the muscimol-dependent activation of phospholipase A2 in glioma C6 cells.
Topics: Animals; Anti-Anxiety Agents; Arachidonic Acid; Arachidonic Acids; Cell Line; Chromatography, High P | 1985 |
Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.
Topics: Astrocytoma; Benzodiazepines; Benzodiazepinones; Cell Division; Clonazepam; Diazepam; Female; Flumaz | 1988 |
Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion.
Topics: Adult; Aged; Brain Neoplasms; Carmustine; Carotid Arteries; Diazepam; Droperidol; Drug Therapy, Comb | 1986 |
Myokymia and facial contraction in brain stem glioma. An electromyographic study.
Topics: Action Potentials; Adult; Brain Neoplasms; Carbamazepine; Diazepam; Edrophonium; Electromyography; F | 1974 |