diazepam has been researched along with Glioblastoma in 8 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Herein, we report new quinazoline-urea based compounds with potent cytotoxic activities against TMZ-resistant glioblastoma multiforme (GBM) cells." | 7.81 | Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). ( Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H, 2015) |
| "The combination of lonidamine and diazepam--drugs that target two distinct mitochondrial sites involved in cellular energy metabolism--potentiates the effects of the individual drugs and may prove useful in the treatment of human glioblastomas." | 7.70 | Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment. ( Bourgeois, Y; Bras Gonçalves, R; Dutrillaux, B; Miccoli, L; Oudard, S; Poirson-Bichat, F; Poupon, MF; Sureau, F, 1998) |
| " The LND-diazepam at the used dosing schedule did not show a complete or partial response." | 6.71 | Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme. ( Andrieu, JM; Banu, E; Carpentier, A; Celerier, D; Delattre, JY; Dutrillaux, B; Fauchon, F; Oudard, S; Poupon, MF, 2003) |
| "Diazepam has potential to be a lead for new drugs in GBM therapy because of its antitumor activity." | 5.39 | Diazepam inhibits proliferation of human glioblastoma cells through triggering a G0/G1 cell cycle arrest. ( Cao, L; Chen, J; Hu, J; Lin, J; Lin, S; Mao, L; Ouyang, Y; Yan, G; Yang, X; Zhang, H; Zhou, Y; Zhu, W, 2013) |
| "When hypericin was combined with diazepam, photocytotoxicity was increased in U-87 MG cells and primary cultures unlike U373 MG cells." | 5.33 | Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells. ( Gajdos, M; Kocanová, S; Lavicka, J; Mirossay, A; Mirossay, L; Miskovsky, P; Mojzis, J; Sarissky, M; Sulla, I, 2005) |
| "Herein, we report new quinazoline-urea based compounds with potent cytotoxic activities against TMZ-resistant glioblastoma multiforme (GBM) cells." | 3.81 | Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM). ( Cho, H; Elkamhawy, A; Heo, JC; Kim, HY; Kim, KH; Lee, CO; Nam, DH; Pae, AN; Park, WK; Roh, EJ; Seol, HJ; Viswanath, AN; Yang, H, 2015) |
| "The combination of lonidamine and diazepam--drugs that target two distinct mitochondrial sites involved in cellular energy metabolism--potentiates the effects of the individual drugs and may prove useful in the treatment of human glioblastomas." | 3.70 | Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment. ( Bourgeois, Y; Bras Gonçalves, R; Dutrillaux, B; Miccoli, L; Oudard, S; Poirson-Bichat, F; Poupon, MF; Sureau, F, 1998) |
| " The LND-diazepam at the used dosing schedule did not show a complete or partial response." | 2.71 | Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme. ( Andrieu, JM; Banu, E; Carpentier, A; Celerier, D; Delattre, JY; Dutrillaux, B; Fauchon, F; Oudard, S; Poupon, MF, 2003) |
| "Diazepam has potential to be a lead for new drugs in GBM therapy because of its antitumor activity." | 1.39 | Diazepam inhibits proliferation of human glioblastoma cells through triggering a G0/G1 cell cycle arrest. ( Cao, L; Chen, J; Hu, J; Lin, J; Lin, S; Mao, L; Ouyang, Y; Yan, G; Yang, X; Zhang, H; Zhou, Y; Zhu, W, 2013) |
| "When hypericin was combined with diazepam, photocytotoxicity was increased in U-87 MG cells and primary cultures unlike U373 MG cells." | 1.33 | Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells. ( Gajdos, M; Kocanová, S; Lavicka, J; Mirossay, A; Mirossay, L; Miskovsky, P; Mojzis, J; Sarissky, M; Sulla, I, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Elkamhawy, A | 1 |
| Viswanath, AN | 1 |
| Pae, AN | 1 |
| Kim, HY | 1 |
| Heo, JC | 1 |
| Park, WK | 1 |
| Lee, CO | 1 |
| Yang, H | 1 |
| Kim, KH | 1 |
| Nam, DH | 1 |
| Seol, HJ | 1 |
| Cho, H | 1 |
| Roh, EJ | 1 |
| Drljača, J | 1 |
| Popović, A | 1 |
| Bulajić, D | 1 |
| Stilinović, N | 1 |
| Vidičević Novaković, S | 1 |
| Sekulić, S | 1 |
| Milenković, I | 1 |
| Ninković, S | 1 |
| Ljubković, M | 1 |
| Čapo, I | 1 |
| Chen, J | 1 |
| Ouyang, Y | 1 |
| Cao, L | 1 |
| Zhu, W | 1 |
| Zhou, Y | 2 |
| Zhang, H | 1 |
| Yang, X | 1 |
| Mao, L | 1 |
| Lin, S | 1 |
| Lin, J | 1 |
| Hu, J | 1 |
| Yan, G | 1 |
| Babateen, O | 1 |
| Jin, Z | 1 |
| Bhandage, A | 1 |
| Korol, SV | 1 |
| Westermark, B | 1 |
| Forsberg Nilsson, K | 1 |
| Uhrbom, L | 1 |
| Smits, A | 1 |
| Birnir, B | 1 |
| Oudard, S | 2 |
| Carpentier, A | 1 |
| Banu, E | 1 |
| Fauchon, F | 1 |
| Celerier, D | 1 |
| Poupon, MF | 2 |
| Dutrillaux, B | 2 |
| Andrieu, JM | 1 |
| Delattre, JY | 1 |
| Sarissky, M | 1 |
| Lavicka, J | 1 |
| Kocanová, S | 1 |
| Sulla, I | 1 |
| Mirossay, A | 1 |
| Miskovsky, P | 1 |
| Gajdos, M | 1 |
| Mojzis, J | 1 |
| Mirossay, L | 1 |
| Miccoli, L | 1 |
| Poirson-Bichat, F | 1 |
| Sureau, F | 1 |
| Bras Gonçalves, R | 1 |
| Bourgeois, Y | 1 |
| Klepstad, P | 1 |
| Borchgrevink, P | 1 |
| Hval, B | 1 |
| Flaat, S | 1 |
| Kaasa, S | 1 |
1 trial available for diazepam and Glioblastoma
| Article | Year |
|---|---|
Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Diazepam; Female; Glioblasto | 2003 |
7 other studies available for diazepam and Glioblastoma
| Article | Year |
|---|---|
Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM).
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dacarbazine; Dose-Response Relationship | 2015 |
Diazepam diminishes temozolomide efficacy in the treatment of U87 glioblastoma cell line.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; | 2022 |
Diazepam inhibits proliferation of human glioblastoma cells through triggering a G0/G1 cell cycle arrest.
Topics: Antimetabolites; Benzimidazoles; Blotting, Western; Brain Neoplasms; Bromodeoxyuridine; Cell Cycle; | 2013 |
Etomidate, propofol and diazepam potentiate GABA-evoked GABAA currents in a cell line derived from human glioblastoma.
Topics: Anesthetics, General; Cell Line, Tumor; Diazepam; Drug Synergism; Electrophysiological Phenomena; Et | 2015 |
Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells.
Topics: Adult; Aged; Anthracenes; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Diazepam; Drug Interact | 2005 |
Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Diaz | 1998 |
Long-term treatment with ketamine in a 12-year-old girl with severe neuropathic pain caused by a cervical spinal tumor.
Topics: Analgesia, Patient-Controlled; Analgesics; Brain Stem; Cervical Vertebrae; Child; Diazepam; Drug Res | 2001 |