diazepam has been researched along with Glial Cell Tumors in 20 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells." | 7.71 | Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line. ( Lavicka, J; Mirossay, A; Mirossay, L; Mojzis, J; Sarisský, M; Sulla, I, 2001) |
| "The C6-2B glioma cell line, rich in mitochondrial receptors that bind with high affinity to benzodiazepines, imidazopyridines, and isoquinolinecarboxamides (previously called peripheral-type benzodiazepine receptors), was investigated as a model to study the significance of the polypeptide diazepam binding inhibitor (DBI) and the putative DBI processing products on mitochondrial receptor-regulated steroidogenesis." | 7.68 | Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. ( Costa, E; Guarneri, P; Guidotti, A; Kreuger, KE; Papadopoulos, V, 1992) |
| "Five milligrams of intravenous diazepam given prior to contrast media injection statistically significantly reduced the incidence of contrast media-associated seizures from 16% to 2% in a prospective, randomized series of glioma patients." | 7.67 | Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography. ( Bigelow, RH; Hayman, LA; Lepke, RA; Libshitz, HI; Pagani, JJ, 1984) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 7.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| " In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells." | 3.71 | Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line. ( Lavicka, J; Mirossay, A; Mirossay, L; Mojzis, J; Sarisský, M; Sulla, I, 2001) |
| "The C6-2B glioma cell line, rich in mitochondrial receptors that bind with high affinity to benzodiazepines, imidazopyridines, and isoquinolinecarboxamides (previously called peripheral-type benzodiazepine receptors), was investigated as a model to study the significance of the polypeptide diazepam binding inhibitor (DBI) and the putative DBI processing products on mitochondrial receptor-regulated steroidogenesis." | 3.68 | Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor. ( Costa, E; Guarneri, P; Guidotti, A; Kreuger, KE; Papadopoulos, V, 1992) |
| "We have demonstrated high affinity diazepam binding sites of the Ro5-4864 benzodiazepine receptor subtype on 108CC15 neuroblastoma X glioma hybrid cells." | 3.67 | Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells. ( Snell, CR; Snell, PH, 1984) |
| "Five milligrams of intravenous diazepam given prior to contrast media injection statistically significantly reduced the incidence of contrast media-associated seizures from 16% to 2% in a prospective, randomized series of glioma patients." | 3.67 | Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography. ( Bigelow, RH; Hayman, LA; Lepke, RA; Libshitz, HI; Pagani, JJ, 1984) |
| "The benzodiazepines, Ro 5-4864, diazepam, clonazepam, and also PK-11195, inhibited, at micromolar concentrations, the proliferation of rat C6 glioma and mouse neuro-2A neuroblastoma cells in culture." | 3.67 | Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor. ( Gorman, AM; O'Beirne, GB; Regan, CM; Williams, DC, 1989) |
| "The effects of several benzodiazepines (diazepam, clonazepam, Ro 15-1788 and Ro 5-4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay." | 3.67 | Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro. ( Kunert-Radek, J; Pawlikowski, M; Radek, A; Stepien, H, 1988) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 3.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| " dosing was followed by rapid elimination of the drug and was ineffective." | 1.35 | Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand. ( Beaudry, F; Berger, F; Falardeau, P; Farnet, CM; Gourdeau, H; McAlpine, JB; Ranger, M; Simard, B, 2008) |
| "Reported are three patients with ictal monoparesis of an arm." | 1.33 | Ictal monoparesis associated with lesions in the primary somatosensory area. ( Aoki, T; Hanakawa, T; Hitomi, T; Ikeda, A; Matsumoto, R; Miki, Y; Shibasaki, H; Shimohama, S; Tomimoto, H, 2005) |
| "Brief limbic seizures were evoked by intraamygdala kainic acid to elicit unilateral death of target hippocampal CA3 neurons in the rat." | 1.31 | Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures. ( Araki, T; Bonislawski, DP; Henshall, DC; Lan, JQ; Meller, R; Minami, M; Schindler, CK; Simon, RP; Skradski, SL, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (65.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 4 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Henshall, DC | 1 |
| Skradski, SL | 1 |
| Meller, R | 1 |
| Araki, T | 1 |
| Minami, M | 1 |
| Schindler, CK | 1 |
| Lan, JQ | 1 |
| Bonislawski, DP | 1 |
| Simon, RP | 1 |
| Matsumoto, R | 1 |
| Ikeda, A | 1 |
| Hitomi, T | 1 |
| Aoki, T | 1 |
| Hanakawa, T | 1 |
| Miki, Y | 1 |
| Tomimoto, H | 1 |
| Shimohama, S | 1 |
| Shibasaki, H | 1 |
| Gourdeau, H | 1 |
| McAlpine, JB | 1 |
| Ranger, M | 1 |
| Simard, B | 1 |
| Berger, F | 1 |
| Beaudry, F | 1 |
| Farnet, CM | 1 |
| Falardeau, P | 1 |
| Snell, CR | 1 |
| Snell, PH | 1 |
| Gallager, DW | 1 |
| Mallorga, P | 1 |
| Oertel, W | 1 |
| Henneberry, R | 1 |
| Tallman, J | 1 |
| Thomas, JW | 1 |
| Tallman, JF | 1 |
| Zlobina, GP | 2 |
| Kondakova, LI | 2 |
| Mukhin, AG | 1 |
| Pagani, JJ | 1 |
| Hayman, LA | 1 |
| Bigelow, RH | 1 |
| Libshitz, HI | 1 |
| Lepke, RA | 1 |
| Khalansky, AS | 1 |
| Ishizawa, Y | 1 |
| Furuya, K | 1 |
| Yamagishi, S | 1 |
| Dohi, S | 1 |
| Oudard, S | 1 |
| Miccoli, L | 1 |
| Dutrillaux, B | 1 |
| Poupon, MF | 1 |
| Lavicka, J | 1 |
| Sarisský, M | 1 |
| Mirossay, A | 1 |
| Sulla, I | 1 |
| Mojzis, J | 1 |
| Mirossay, L | 1 |
| Propst, F | 1 |
| Moroder, L | 1 |
| Wünsch, E | 1 |
| Hamprecht, B | 1 |
| Syapin, PJ | 1 |
| Skolnick, P | 1 |
| Papadopoulos, V | 1 |
| Guarneri, P | 1 |
| Kreuger, KE | 1 |
| Guidotti, A | 1 |
| Costa, E | 1 |
| Gorman, AM | 1 |
| O'Beirne, GB | 1 |
| Regan, CM | 1 |
| Williams, DC | 1 |
| Majewska, MD | 1 |
| Chuang, DM | 1 |
| Pawlikowski, M | 1 |
| Kunert-Radek, J | 1 |
| Radek, A | 1 |
| Stepien, H | 1 |
| Klein, DS | 1 |
| Klein, PW | 1 |
| Mahaley, MS | 1 |
| Tenser, RB | 1 |
| Corbett, JJ | 1 |
1 review available for diazepam and Glial Cell Tumors
| Article | Year |
|---|---|
[Targeting the gene of glucose metabolism for the treatment of advanced gliomas].
Topics: Antineoplastic Agents; Brain; Brain Neoplasms; Chromosome Deletion; Diazepam; Glioma; Glucose; Glyco | 1998 |
19 other studies available for diazepam and Glial Cell Tumors
| Article | Year |
|---|---|
Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
Topics: Amygdala; Animals; Apoptosis; Caspase 6; Caspase 7; Caspases; Convulsants; Diazepam; Electroencephal | 2002 |
Ictal monoparesis associated with lesions in the primary somatosensory area.
Topics: Adult; Arm; Brain Damage, Chronic; Brain Neoplasms; Cerebral Angiography; Cerebral Veins; Diazepam; | 2005 |
Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Benzodiazepines; Brain Neoplasms; Cell Line, Tumor | 2008 |
Benzodiazepines modulate the A2 adenosine binding sites on 108CC15 neuroblastoma X glioma hybrid cells.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Binding, Competitive; Cells, Cultured; Clonazepam; Cy | 1984 |
[3H]Diazepam binding in mammalian central nervous system: a pharmacological characterization.
Topics: Animals; Binding, Competitive; Cell Line; Cells, Cultured; Cerebral Cortex; Diazepam; Fetus; Fibrobl | 1981 |
Characterization of photoaffinity labeling of benzodiazepine binding sites.
Topics: Affinity Labels; Animals; Benzodiazepines; Brain; Cell Line; Cell Membrane; Cerebral Cortex; Corpus | 1981 |
[Benzodiazepine receptors of the mouse glioblastoma cell line: the anomalous effect of gamma-aminobutyric acid on diazepam binding].
Topics: Animals; Benzodiazepines; Brain Neoplasms; Cell Line; Cells, Cultured; Diazepam; gamma-Aminobutyric | 1982 |
Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography.
Topics: Adolescent; Adult; Brain Neoplasms; Contrast Media; Diazepam; Drug Evaluation; Female; Glioma; Human | 1984 |
Specific binding of [3H]diazepam in mouse glioblastoma: the influence of clonazepam and Ro 5-4864 on [3H]diazepam binding.
Topics: Animals; Benzodiazepinones; Binding Sites; Cell Line; Clonazepam; Diazepam; Glioma; Mice; Neuroglia | 1984 |
Non-GABAergic effects of midazolam, diazepam and flumazenil on voltage-dependent ion currents in NG108-15 cells.
Topics: Animals; Calcium Channels; Diazepam; Dose-Response Relationship, Drug; Flumazenil; gamma-Aminobutyri | 1997 |
Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line.
Topics: Anticonvulsants; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; | 2001 |
The influence of secretin, glucagon and other peptides, of amino acids, prostaglandin endoperoxide analogues and diazepam on the level of adenosine 3',5'-cyclic monophosphate in neuroblastoma x glioma hybrid cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acids; Cyclic AMP | 1979 |
Characterization of benzodiazepine binding sites in cultured cells of neural origin.
Topics: Animals; Astrocytoma; Cell Line; Cell Membrane; Cerebral Cortex; Diazepam; Glioma; Humans; Kinetics; | 1979 |
Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor.
Topics: Animals; Cholesterol Side-Chain Cleavage Enzyme; Diazepam; Diazepam Binding Inhibitor; Glioma; In Vi | 1992 |
Antiproliferative action of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Blood; Cell Division; Clonazepam; Diazepam; DNA; Glioma | 1989 |
Benzodiazepines enhance the muscimol-dependent activation of phospholipase A2 in glioma C6 cells.
Topics: Animals; Anti-Anxiety Agents; Arachidonic Acid; Arachidonic Acids; Cell Line; Chromatography, High P | 1985 |
Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.
Topics: Astrocytoma; Benzodiazepines; Benzodiazepinones; Cell Division; Clonazepam; Diazepam; Female; Flumaz | 1988 |
Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion.
Topics: Adult; Aged; Brain Neoplasms; Carmustine; Carotid Arteries; Diazepam; Droperidol; Drug Therapy, Comb | 1986 |
Myokymia and facial contraction in brain stem glioma. An electromyographic study.
Topics: Action Potentials; Adult; Brain Neoplasms; Carbamazepine; Diazepam; Edrophonium; Electromyography; F | 1974 |