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diazepam and Epilepsy, Temporal Lobe

diazepam has been researched along with Epilepsy, Temporal Lobe in 67 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Epilepsy, Temporal Lobe: A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321).

Research Excerpts

ExcerptRelevanceReference
"Injection of the seaweed toxin kainic acid (KA) in rats induces a severe status epilepticus initiating complex neuropathological changes in limbic brain areas and subsequently spontaneous recurrent seizures."7.78Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex. ( Drexel, M; Preidt, AP; Sperk, G, 2012)
"Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs."5.40Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014)
"QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)."5.27Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986)
" Clonazepam, chlorazepate, nitrazepam and clobazam are also prescribed as chronic treatment of various forms of epilepsy."4.76[Benzodiazepines in the treatment of epilepsy]. ( Loiseau, P, 1983)
" Results from 2413 mice were evaluated for effects of sex, age, body weight, and latency between administration of atropine methyl bromide and pilocarpine."3.78Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Haney, MM, 2012)
"Injection of the seaweed toxin kainic acid (KA) in rats induces a severe status epilepticus initiating complex neuropathological changes in limbic brain areas and subsequently spontaneous recurrent seizures."3.78Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex. ( Drexel, M; Preidt, AP; Sperk, G, 2012)
"Lithium-pilocarpine induces status epilepticus (SE), leading to extensive damage and spontaneous recurrent seizures (SRS)."3.73The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy. ( Ferrandon, A; François, J; Koning, E; Nehlig, A, 2006)
"When flumazenil (3 mg) was administered immediately after intravenous diazepam (10 mg), the reduction in interictal epileptic activity was not significantly different from that produced by diazepam alone."2.67The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study. ( Hart, YM; Meinardi, H; Nutt, DJ; Sander, JW; Shorvon, SD, 1991)
"Drug treatment of status epilepticus is reviewed."2.36Drug therapy reviews: drug therapy of status epilepticus. ( Browne, TR, 1978)
"Clonazepam is a new benzodiazepine anticonvulsant recently approved by the Food and Drug Administration for the treatment of typical absence, infantile myoclonic, atypical absence, myoclonic, and akinetic seizures."2.35Clonazepam. A review of a new anticonvulsant drug. ( Browne, TR, 1976)
"Only diazepam significantly increased seizure freedom."1.72Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs. ( Billingsley, P; Metcalf, CS; Pruess, T; Rueda, C; Saunders, GW; Smith, MD; Thomson, K; West, PJ; Wilcox, KS, 2022)
"In a first step, we examined anti-seizure effects of 6 AEDs on spontaneous recurrent focal electrographic seizures and secondarily generalized convulsive seizures in epileptic mice, showing that the focal nonconvulsive seizures were resistant to carbamazepine and phenytoin, whereas valproate and levetiracetam exerted moderate and phenobarbital and diazepam marked anti-seizure effects."1.42Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice. ( Bankstahl, M; Klein, S; Löscher, W, 2015)
"Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs."1.40Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014)
" We used male NMRI mice (28-32 g) and first established the dose-response relationship for pilocarpine (250-400 mg/kg; ip) to induce status epilepticus (SE)."1.38Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization. ( Kaminski, RM; Kumar, G; Mazzuferi, M; Rospo, C, 2012)
"Temporal lobe epilepsy is prevalent and can be difficult to treat effectively."1.37Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Lew, FH, 2011)
"The presence of multiple seizures prior to medical treatment has been suggested as a potential predictor of poor outcome."1.36High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy. ( Brandt, C; Löscher, W, 2010)
"QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)."1.27Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986)

Research

Studies (67)

TimeframeStudies, this research(%)All Research%
pre-199043 (64.18)18.7374
1990's2 (2.99)18.2507
2000's8 (11.94)29.6817
2010's12 (17.91)24.3611
2020's2 (2.99)2.80

Authors

AuthorsStudies
West, PJ1
Thomson, K1
Billingsley, P1
Pruess, T1
Rueda, C1
Saunders, GW1
Smith, MD1
Metcalf, CS1
Wilcox, KS1
Gurrell, R1
Iredale, P1
Evrard, A1
Duveau, V1
Ruggiero, C1
Roucard, C1
Xiao, Z1
Peng, J1
Gan, N1
Arafat, A1
Yin, F1
Mante, PK1
Adongo, DW1
Woode, E1
Sherdil, A1
Chabardès, S1
Guillemain, I1
Michallat, S1
Prabhu, S1
Pernet-Gallay, K1
David, O1
Piallat, B1
Wang, S1
Lévesque, M1
Avoli, M1
Klein, S2
Bankstahl, M2
Gramer, M1
Hausknecht, M1
Löscher, W3
Brandt, C1
Buckmaster, PS2
Lew, FH1
Perez-Mendes, P1
Blanco, MM1
Calcagnotto, ME1
Cinini, SM1
Bachiega, J1
Papoti, D1
Covolan, L1
Tannus, A1
Mello, LE1
Haney, MM1
Drexel, M1
Preidt, AP1
Sperk, G1
Mazzuferi, M1
Kumar, G1
Rospo, C1
Kaminski, RM1
Wellmer, J1
Su, H1
Beck, H1
Yaari, Y1
GALAMBOS, M1
Vielhaber, S1
Kudin, AP1
Kudina, TA1
Stiller, D1
Scheich, H1
Schoenfeld, A1
Feistner, H1
Heinze, HJ1
Elger, CE1
Kunz, WS1
Leroy, C1
Poisbeau, P1
Keller, AF1
Nehlig, A2
Waruiru, C1
Appleton, R1
Ricci, GB1
De Carli, D1
Colonnese, C1
Di Gennaro, G1
Quarato, PP1
Cantore, G1
Esposito, V1
Garreffa, G1
Maraviglia, B1
François, J1
Koning, E1
Ferrandon, A1
Robertson, HA1
Loiseau, P1
Graham, B1
Freemon, FR1
Murasaki, M1
Inami, M1
Okamoto, K1
Muraoka, H1
Takahashi, A1
Sumiyoshi, A1
Yamazumi, S1
Dodman, NH1
Bronson, R1
Gliatto, J1
Kapur, J2
Mtchedlishvili, Z1
Bertram, EH1
Browne, TR3
Adebimpe, VR1
Kullander, S1
Brazier, MA1
Crandall, PH1
Walsh, GO1
Hart, YM1
Meinardi, H1
Sander, JW1
Nutt, DJ1
Shorvon, SD1
Bromfield, EB1
Dambrosia, J1
Devinsky, O1
Nice, FJ1
Theodore, WH1
Rennert, H1
Vezzani, A1
Wu, HQ1
Tullii, M1
Samanin, R1
Parish, RA1
Brownstein, D1
Namer, IJ1
Tan, E1
Ciğer, A1
Zileli, T1
Hofmann, WE1
Przuntek, H1
Falconer, MA1
Parsonage, M2
Pomina, AC1
Tarlau, M1
Berman, AJ1
Hershon, HI1
Penry, JK1
Hooshmand, H1
Suter, CG1
Friedlander, WJ1
Wilson, J1
Ritter, G1
Lieb, J1
Sclabassi, R1
Crandall, P1
Buchness, R1
Malcolm, MT1
Tharp, BR1
Fromm, GH1
Amores, CY1
Thies, W1
Pürgyi, P1
Hegedic, Z1
Brett, EM1
Trolle, E1
Prensky, AL1
Raff, MC1
Moore, MJ1
Schwab, RS1
Müller, HR1
Klingler, M1
Kaeser, HE1
Wurmser, P1
Hirt, HR1
Henriksen, PB1
Nicol, CF1
Tutton, JC1
Smith, BH1
Elian, M1
Niedermeyer, E1
Dowzenko, A1
Huber, Z1
Zieliński, JJ1
Borkowska, Z1
Mazurkowa, K1
Wojakowski, A1
Hernándex-Peón, R1
Chávez-Ibarra, G1
Rincón-Trujillo, JA1
Rallo Piqué, E1
Henking, R1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A 57-Week, Multicenter, Active-treatment, Open-label Extension Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures[NCT04686786]Phase 2120 participants (Anticipated)Interventional2020-12-08Enrolling by invitation
A Randomized, Double-blind, Placebo-controlled, Parallel Group, Multicenter Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures (REALIZE Trial)[NCT04244175]Phase 2150 participants (Anticipated)Interventional2020-01-27Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for diazepam and Epilepsy, Temporal Lobe

ArticleYear
Febrile seizures: an update.
    Archives of disease in childhood, 2004, Volume: 89, Issue:8

    Topics: Anticonvulsants; Central Nervous System Diseases; Child; Diazepam; Epilepsy, Temporal Lobe; Humans;

2004
[Benzodiazepines in the treatment of epilepsy].
    L'Encephale, 1983, Volume: 9, Issue:4 Suppl 2

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobazam

1983
Drug therapy reviews: drug therapy of status epilepticus.
    American journal of hospital pharmacy, 1978, Volume: 35, Issue:8

    Topics: Anesthesia, General; Diazepam; Epilepsies, Partial; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epil

1978
Clonazepam. A review of a new anticonvulsant drug.
    Archives of neurology, 1976, Volume: 33, Issue:5

    Topics: Adult; Benzodiazepinones; Brain; Chemical Phenomena; Chemistry; Child; Clonazepam; Diazepam; Drug To

1976
Benzodiazepines in the treatment of epilepsy. A review.
    Epilepsia, 1973, Volume: 14, Issue:3

    Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec

1973
Epilepsy.
    Progress in neurology and psychiatry, 1968, Volume: 23

    Topics: Adolescent; Animals; Barbiturates; Brain Neoplasms; Cell Membrane Permeability; Central Nervous Syst

1968
Recent progress in epilepsy. Diagnostic procedures and treatment.
    California medicine, 1973, Volume: 119, Issue:1

    Topics: Anticonvulsants; Brain Neoplasms; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Temporal Lob

1973

Trials

3 trials available for diazepam and Epilepsy, Temporal Lobe

ArticleYear
The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study.
    Journal of neurology, neurosurgery, and psychiatry, 1991, Volume: 54, Issue:4

    Topics: Adult; Anticonvulsants; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination

1991
Comparative trial of diazepam and pheneturide in treatment of epilepsy.
    Lancet (London, England), 1969, Oct-25, Volume: 2, Issue:7626

    Topics: Age Factors; Diazepam; Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Male; Stress, Psychologica

1969
Acute treatment of epileptic seizures with diazepamum (Valium).
    Acta neurologica Scandinavica, 1967, Volume: 43, Issue:S31

    Topics: Acute Disease; Adolescent; Adult; Aged; Aphasia; Clinical Trials as Topic; Diazepam; Epilepsy; Epile

1967

Other Studies

57 other studies available for diazepam and Epilepsy, Temporal Lobe

ArticleYear
Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs.
    Experimental neurology, 2022, Volume: 349

    Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Diazepam; Disease Models, Animal;

2022
Pronounced antiseizure activity of the subtype-selective GABA
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:11

    Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal

2022
Pronounced antiseizure activity of the subtype-selective GABA
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:11

    Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal

2022
Pronounced antiseizure activity of the subtype-selective GABA
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:11

    Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal

2022
Pronounced antiseizure activity of the subtype-selective GABA
    CNS neuroscience & therapeutics, 2022, Volume: 28, Issue:11

    Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal

2022
Interleukin-1β Plays a Pivotal Role via the PI3K/Akt/mTOR Signaling Pathway in the Chronicity of Mesial Temporal Lobe Epilepsy.
    Neuroimmunomodulation, 2016, Volume: 23, Issue:5-6

    Topics: Animals; Anticonvulsants; Cells, Cultured; Child; Diazepam; Disease Models, Animal; Enzyme Inhibitor

2016
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
    BMC research notes, 2017, Apr-26, Volume: 10, Issue:1

    Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administra

2017
An on demand macaque model of mesial temporal lobe seizures induced by unilateral intra hippocampal injection of penicillin.
    Epilepsy research, 2018, Volume: 142

    Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rel

2018
Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy.
    Epilepsy research, 2019, Volume: 152

    Topics: Animals; Anticonvulsants; Brain Waves; Diazepam; Disease Models, Animal; Drug Combinations; Electroe

2019
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
    Epilepsy research, 2014, Volume: 108, Issue:10

    Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism;

2014
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
    Neuropharmacology, 2015, Volume: 90

    Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrod

2015
High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.
    Epilepsia, 2010, Volume: 51, Issue:1

    Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Respons

2010
Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Feb-09, Volume: 31, Issue:6

    Topics: Analysis of Variance; Animals; Anticonvulsants; Cation Transport Proteins; Diazepam; Disease Models,

2011
Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate.
    Epilepsy research, 2011, Volume: 96, Issue:1-2

    Topics: Analysis of Variance; Animals; Anticonvulsants; Benzoxazines; Callithrix; Diazepam; Disease Models,

2011
Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy.
    Epilepsy research, 2012, Volume: 102, Issue:3

    Topics: Age Factors; Animals; Anticonvulsants; Atropine; Body Weight; Diazepam; Disease Models, Animal; Epil

2012
Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex.
    Neuropharmacology, 2012, Volume: 63, Issue:5

    Topics: Animals; Anticonvulsants; Astrocytes; Diazepam; Disease Models, Animal; Drug Resistance; Entorhinal

2012
Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization.
    Experimental neurology, 2012, Volume: 238, Issue:2

    Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela

2012
Long-lasting modification of intrinsic discharge properties in subicular neurons following status epilepticus.
    The European journal of neuroscience, 2002, Volume: 16, Issue:2

    Topics: Action Potentials; Animals; Anticonvulsants; Calcium Channels; Calcium Signaling; Cell Membrane; Dia

2002
LONG TERM CLINICAL TRIAL WITH DIAZEPAM ON ADULT MENTALLY RETARDED PERSONS.
    Diseases of the nervous system, 1965, Volume: 26

    Topics: Adult; Brain; Brain Damage, Chronic; Diazepam; Drug Therapy; Epilepsy; Epilepsy, Absence; Epilepsy,

1965
Hippocampal N-acetyl aspartate levels do not mirror neuronal cell densities in creatine-supplemented epileptic rats.
    The European journal of neuroscience, 2003, Volume: 18, Issue:8

    Topics: Animals; Anticonvulsants; Aspartic Acid; Cell Count; Creatine; Diazepam; Disease Models, Animal; Epi

2003
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
    The Journal of physiology, 2004, Jun-01, Volume: 557, Issue:Pt 2

    Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep

2004
Hemodynamic response (BOLD/fMRI) in focal epilepsy with reference to benzodiazepine effect.
    Magnetic resonance imaging, 2004, Volume: 22, Issue:10

    Topics: Adult; Anticonvulsants; Brain; Diazepam; Echo-Planar Imaging; Electroencephalography; Epilepsies, Pa

2004
The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
    Epilepsy research, 2006, Volume: 72, Issue:2-3

    Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Therapy, Combination; Electroenceph

2006
Evidence for distinct benzodiazepine receptors for anticonvulsant and sedative actions: implications for the treatment of temporal lobe epilepsy.
    Progress in neuro-psychopharmacology & biological psychiatry, 1983, Volume: 7, Issue:4-6

    Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Epilepsy, Temporal Lobe; Flumazenil

1983
Continuous psychomotor seizures presenting as longstanding mental illness.
    Southern medical journal, 1982, Volume: 75, Issue:4

    Topics: Confusion; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy, Temporal Lobe; Human

1982
Psychomotor status induced by temporal lobe encephalitis.
    Folia psychiatrica et neurologica japonica, 1981, Volume: 35, Issue:2

    Topics: Automatism; Carbamazepine; Clonazepam; Diazepam; Electroencephalography; Encephalitis; Epilepsy, Tem

1981
Tail chasing in a bull terrier.
    Journal of the American Veterinary Medical Association, 1993, Mar-01, Volume: 202, Issue:5

    Topics: Aggression; Animals; Behavior, Animal; Diazepam; Dog Diseases; Dogs; Electroencephalography; Epileps

1993
Hippocampal neurons express GABA A receptor insensitive to diazepam in hyperexcitable conditions.
    Epilepsia, 2000, Volume: 41 Suppl 6

    Topics: Animals; Dentate Gyrus; Diazepam; Epilepsy, Temporal Lobe; Hippocampus; Neurons; Patch-Clamp Techniq

2000
Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.
    The Journal of physiology, 2001, Dec-01, Volume: 537, Issue:Pt 2

    Topics: Animals; Anticonvulsants; Chronic Disease; Diazepam; Electric Conductivity; Epilepsy, Temporal Lobe;

2001
Complex partial seizures simulating schizophrenia .
    JAMA, 1977, Mar-28, Volume: 237, Issue:13

    Topics: Adult; Chlorpromazine; Diagnosis, Differential; Diagnostic Errors; Diazepam; Electroencephalography;

1977
Effect of 2 br-alpha-ergocryptin (CB 154) on serum prolactin and the clinical picture in a case of progressive gigantomastia in pregnancy.
    Annales chirurgiae et gynaecologiae, 1976, Volume: 65, Issue:4

    Topics: Adult; Breast Diseases; Bromocriptine; Carbamazepine; Diazepam; Epilepsy, Temporal Lobe; Ergolines;

1976
Enhancement of EEG lateralizing signs in temporal lobe epilepsy: a trial of diazepam.
    Experimental neurology, 1976, Volume: 51, Issue:1

    Topics: Adolescent; Adult; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy, Temporal Lob

1976
Phenytoin withdrawal and seizure frequency.
    Neurology, 1989, Volume: 39, Issue:7

    Topics: Adult; Carbamazepine; Diazepam; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal Lobe; Female

1989
[Some suggestions on epileptic psychoses, their differential diagnosis and therapy].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1986, Volume: 38, Issue:2

    Topics: Anticonvulsants; Antipsychotic Agents; Clonazepam; Dementia; Diagnosis, Differential; Diazepam; Drug

1986
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 239, Issue:1

    Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models,

1986
Emergency department management of children with acute isoniazid poisoning.
    Pediatric emergency care, 1986, Volume: 2, Issue:2

    Topics: Adolescent; Child; Diazepam; Emergencies; Epilepsies, Partial; Epilepsy, Temporal Lobe; Epilepsy, To

1986
[Complex partial epileptic seizures as the initial symptom of subacute sclerosing panencephalitis].
    Revue neurologique, 1986, Volume: 142, Issue:12

    Topics: Adolescent; Diazepam; Electroencephalography; Epilepsy, Temporal Lobe; Humans; Male; Subacute Sclero

1986
[Partial seizure status with complex symptomatology. Case report on the problem of diagnostic difficulties].
    Der Nervenarzt, 1986, Volume: 57, Issue:1

    Topics: Adult; Carbamazepine; Diagnosis, Differential; Diazepam; Drug Therapy, Combination; Electroencephalo

1986
Mesial temporal (Ammon's horn) sclerosis as a common cause of epilepsy. Aetiology, treatment, and prevention.
    Lancet (London, England), 1974, Sep-28, Volume: 2, Issue:7883

    Topics: Administration, Oral; Adolescent; Animals; Brain Diseases; Child; Child, Preschool; Diazepam; Epilep

1974
Epilepsy.
    The Practitioner, 1974, Volume: 213, Issue:1276 SPEC

    Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec

1974
Comparative anticonvulsant effect of several Librium analogs.
    Electroencephalography and clinical neurophysiology, 1967, Volume: 23, Issue:1

    Topics: Chlordiazepoxide; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal

1967
Classification and treatment of seizure disorders in children.
    Virginia medical monthly, 1970, Volume: 97, Issue:2

    Topics: Acetazolamide; Adolescent; Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child,

1970
Drug treatment of epilepsy in childhood.
    British medical journal, 1969, Nov-22, Volume: 4, Issue:5681

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Absence; Epil

1969
[Therapy of epilepsy. The causes and consequences of inadequate treatment].
    Deutsche medizinische Wochenschrift (1946), 1972, Oct-13, Volume: 97, Issue:41

    Topics: Acridines; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Barbiturates; Carbamazepine; Child

1972
Comparison of the action of diazepam and phenobarbital using EEG-derived power spectra obtained from temporal lobe epileptics.
    Neuropharmacology, 1974, Volume: 13, Issue:8

    Topics: Adult; Amygdala; Cerebral Cortex; Diazepam; Electrodes, Implanted; Electroencephalography; Epilepsy,

1974
Temporal lobe epilepsy due to drug withdrawal.
    The British journal of addiction to alcohol and other drugs, 1972, Volume: 67, Issue:4

    Topics: Barbiturates; Diazepam; Electroencephalography; Epilepsy, Temporal Lobe; Female; Humans; Middle Aged

1972
Imipramine in epilepsy.
    Archives of neurology, 1972, Volume: 27, Issue:3

    Topics: Adolescent; Animals; Anticonvulsants; Cats; Child; Child, Preschool; Diazepam; Electroencephalograph

1972
[Three acute diphenylhydantoin-intoxications (author's transl)].
    Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie, 1974, Volume: 114, Issue:1

    Topics: Adolescent; Adult; Alcoholic Intoxication; Diazepam; Drug Combinations; Electroencephalography; Epil

1974
Treatment of febrile convulsions.
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:5

    Topics: Anticonvulsants; Aspirin; Child; Child, Preschool; Diazepam; Epilepsy, Temporal Lobe; Fever; Humans;

1974
Diazepam (valium) in the treatment of epilepsy. A report of fifty cases.
    Acta neurologica Scandinavica. Supplementum, 1965, Volume: 13 Pt 2

    Topics: Adolescent; Adult; Anticonvulsants; Child; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal

1965
Intravenous diazepam in the treatment of prolonged seizure activity.
    The New England journal of medicine, 1967, Apr-06, Volume: 276, Issue:14

    Topics: Adolescent; Adult; Aged; Barbiturates; Child; Diazepam; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clo

1967
[On the treatment of the status epilepticus with diazepam (Valium). Experiences in 12 cases].
    Schweizerische medizinische Wochenschrift, 1966, Jan-29, Volume: 96, Issue:4

    Topics: Adolescent; Adult; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Humans; Male; Mid

1966
Parenteral diazepam in status epilepticus.
    Neurology, 1969, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Aged; Alcoholism; Brain Neoplasms; Child; Child, Preschool; Diazepam; Electroence

1969
The long-term oral use of valium (diazepam) in epilepsy.
    Epilepsia, 1969, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsies, Partial; E

1969
Electroencephalographic studies on the anticonvulsive action of intravenous diazepam.
    European neurology, 1970, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epile

1970
[Problems of treatment of epilepsy].
    Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3

    Topics: Anemia, Macrocytic; Anticonvulsants; Bromides; Diazepam; Drug Synergism; Epilepsy; Epilepsy, Tempora

1971
[Results of treatment of epilepsy in children up to 14 years of age].
    Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3

    Topics: Adolescent; Age Factors; Barbiturates; Child; Child, Preschool; Diazepam; Drug Synergism; Electroenc

1971
Temporal lobe seizures with psychomotor status.
    Journal of the Tennessee Medical Association, 1969, Volume: 62, Issue:11

    Topics: Amphetamine; Child; Diazepam; Epilepsy, Temporal Lobe; Humans; Male

1969
Localizing action of Valium on temporal lobe epileptogenic foci with depth electrodes.
    Pharmacology, 1968, Volume: 1, Issue:5

    Topics: Adolescent; Diazepam; Electroencephalography; Epilepsy, Temporal Lobe; Humans; Male; Sleep

1968
[Clinical and electroencephalographic experimentation with intravenous diazepam in epileptic diseases].
    Psychiatria et neurologia, 1965, Volume: 150, Issue:4

    Topics: Adult; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy, Temporal Lobe; Female; H

1965