diazepam and Epilepsy, Complex Partial studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Epilepsy, Complex Partial: A disorder characterized by recurrent partial seizures marked by impairment of cognition. During the seizure the individual may experience a wide variety of psychic phenomenon including formed hallucinations, illusions, deja vu, intense emotional feelings, confusion, and spatial disorientation. Focal motor activity, sensory alterations and AUTOMATISM may also occur. Complex partial seizures often originate from foci in one or both temporal lobes. The etiology may be idiopathic (cryptogenic partial complex epilepsy) or occur as a secondary manifestation of a focal cortical lesion (symptomatic partial complex epilepsy). (From Adams et al., Principles of Neurology, 6th ed, pp317-8)

Research Excerpts

Excerpt	Relevance	Reference
" We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures."	9.09	Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. ( Besag, FM; Neville, BG; Scott, RC, 1999)
" We aimed to find out whether there are differences in efficacy and adverse events between buccal administration of liquid midazolam and rectal administration of liquid diazepam in the acute treatment of seizures."	5.09	Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. ( Besag, FM; Neville, BG; Scott, RC, 1999)
"Upon treatment with diazepam and haloperidol, the psychosis subsided within three days."	1.34	[Postictal paranoid-hallucinatory psychosis in cryptogenic epilepsy]. ( Baum, P; Hermann, W; Kopf, A; Wagner, A, 2007)
"Patients with epileptic and nonepileptic seizures are commonly encountered in clinical practice, and they can pose a difficult diagnostic problem."	1.30	Cerebral perfusion SPECT imaging in epileptic and nonepileptic seizures. ( Blend, MJ; de León, OA; Gaviria, M; Jobe, TH; Lin, Q; Sychra, JJ, 1997)

Research

Studies (8)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Length of Seizure After Study Medication Administration

Number of Patients Needed to be Seen or Treated in the Emergency Department for Their Seizure and Use of Study Medication.

Number of Patients That Were Admitted to the Hospital After Their Seizure and Use of Study Medication.

Number of Patients Who Had a Repeat Seizure Within 12 Hours After Their Seizure Who Used Study Medication

Number of Patients Who Needed Additional Medication to Treat the Seizure in the Emergency Department Within 24 Hours

Respiratory Depression Requiring Intubation

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	7 (87.50)	18.2507
2000's	1 (12.50)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Baum, P	1
Kopf, A	1
Hermann, W	1
Wagner, A	1
Cortina, J	1
Ancillo, P	1
Duarte, J	1
Sempere, AP	1
Coria, F	1
Clavería, LE	1
Wakai, S	1
Ito, N	1
Sueoka, H	1
Kawamoto, Y	1
Hayasaka, H	1
Tsutsumi, H	1
Chiba, S	1
Scholtes, FB	1
Renier, WO	1
Meinardi, H	1
Kaplan, PW	1
Blend, MJ	1
de León, OA	1
Jobe, TH	1
Lin, Q	1
Sychra, JJ	1
Gaviria, M	1
Doose, H	1
Scott, RC	1
Besag, FM	1
Neville, BG	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612]	Phase 2	358 participants (Actual)	Interventional	2006-06-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Minutes (Median)
Intranasal Midazolam	3.0
Rectal Diazepam	4.3

Intervention	participants (Number)
Intranasal Midazolam	21
Rectal Diazepam	17

Intervention	participants (Number)
Intranasal Midazolam	4
Rectal Diazepam	3

Intervention	participants (Number)
Intranasal Midazolam	1
Rectal Diazepam	1

Intervention	participants (Number)
Intranasal Midazolam	5
Rectal Diazepam	5

Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours

Respiratory Depression Requiring Oxygen at Discharge From the Emergency Department.

Intervention	participants (Number)
Intranasal Midazolam	1
Rectal Diazepam	0

Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours

Article	Year
[Postictal paranoid-hallucinatory psychosis in cryptogenic epilepsy]. Psychiatrische Praxis, 2007, Volume: 34, Issue:5 Topics: Acute Disease; Adult; Anticonvulsants; Cooperative Behavior; Delusions; Diazepam; Epilepsy; Epilepsy	2007
Intravenous midazolam suppression of complex partial status refractory to intravenous phenytoin and diazepam. Clinical neuropharmacology, 1993, Volume: 16, Issue:5 Topics: Diazepam; Epilepsy, Complex Partial; Female; Humans; Injections, Intravenous; Midazolam; Middle Aged	1993
Complex partial status epilepticus in childhood. Pediatric neurology, 1995, Volume: 13, Issue:2 Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Therapy, Combination; Electroencephalograph	1995
Non-convulsive status epilepticus: causes, treatment, and outcome in 65 patients. Journal of neurology, neurosurgery, and psychiatry, 1996, Volume: 61, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Diazepam; Electroencephalography; Epilepsy, Absence; Epilepsy, C	1996
Nonconvulsive status epilepticus in the emergency room. Epilepsia, 1996, Volume: 37, Issue:7 Topics: Adult; Aged; Anticonvulsants; Confusion; Diagnosis, Differential; Diazepam; Drug Therapy, Combinatio	1996
Cerebral perfusion SPECT imaging in epileptic and nonepileptic seizures. Clinical nuclear medicine, 1997, Volume: 22, Issue:6 Topics: Adult; Anticonvulsants; Brain; Cerebrovascular Circulation; Delta Rhythm; Depression; Diagnosis, Dif	1997
Contradictory conclusions about the possible effects of prolonged febrile convulsions. Epilepsia, 1998, Volume: 39, Issue:1 Topics: Brain; Diazepam; Disease Progression; Electroencephalography; Epilepsies, Myoclonic; Epilepsy, Compl	1998

diazepam and Epilepsy, Complex Partial