diazepam has been researched along with Encephalopathy, Toxic in 9 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we determined the efficacy of two novel neurosteroids, pregnanolone glutamate (PAG) and pregnanolone pyroglutamate (PPG), and tested these drugs in doses of 1-10 mg/kg (ip) against the TMDT syndrome and in our rodent model of infantile spasms." | 8.31 | Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms. ( Chern, CJ; Chern, CR; Chodounská, H; Kudová, E; Lauková, M; Schonwald, A; Shakarjian, MP; Velíšek, L; Velíšková, J, 2023) |
| "In this study, we determined the efficacy of two novel neurosteroids, pregnanolone glutamate (PAG) and pregnanolone pyroglutamate (PPG), and tested these drugs in doses of 1-10 mg/kg (ip) against the TMDT syndrome and in our rodent model of infantile spasms." | 4.31 | Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms. ( Chern, CJ; Chern, CR; Chodounská, H; Kudová, E; Lauková, M; Schonwald, A; Shakarjian, MP; Velíšek, L; Velíšková, J, 2023) |
| " Differentiated human neuroblastoma SH-SY5Y cells were exposed to acrylamide, lindane, parathion, paraoxon, phenytoin, diazepam or caffeine for 72 hours." | 3.74 | Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity. ( Blaauboer, B; Forsby, A, 2007) |
| "Treatment with diazepam ameliorated the spasms, while treatment with the sodium channel antagonist MS-222 ameliorated both spasms and body curvature, suggesting that pyrethroid-induced neurotoxicity is similar in zebrafish and mammals." | 1.36 | Developmental neurotoxicity of pyrethroid insecticides in zebrafish embryos. ( Cooper, KR; DeMicco, A; Richardson, JR; White, LA, 2010) |
| "Diazepam prevents lidocaine-induced seizures, but not neuronal damage in brain structures." | 1.34 | Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats. ( Blas-Valdivia, V; Cano-Europa, E; Hernández-García, A; Ortiz-Butrón, R, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Chern, CR | 3 |
| Lauková, M | 3 |
| Schonwald, A | 3 |
| Kudová, E | 3 |
| Chodounská, H | 3 |
| Chern, CJ | 3 |
| Shakarjian, MP | 3 |
| Velíšková, J | 3 |
| Velíšek, L | 3 |
| Supasai, S | 1 |
| González, EA | 1 |
| Rowland, DJ | 1 |
| Hobson, B | 1 |
| Bruun, DA | 1 |
| Guignet, MA | 1 |
| Soares, S | 1 |
| Singh, V | 1 |
| Wulff, H | 1 |
| Saito, N | 1 |
| Harvey, DJ | 1 |
| Lein, PJ | 1 |
| Kuruba, R | 1 |
| Wu, X | 1 |
| Reddy, DS | 1 |
| DeMicco, A | 1 |
| Cooper, KR | 1 |
| Richardson, JR | 1 |
| White, LA | 1 |
| Golder, FJ | 1 |
| Wilson, J | 1 |
| Larenza, MP | 1 |
| Fink, OT | 1 |
| Taysse, L | 1 |
| Daulon, S | 1 |
| Delamanche, S | 1 |
| Bellier, B | 1 |
| Breton, P | 1 |
| Forsby, A | 1 |
| Blaauboer, B | 1 |
| Blas-Valdivia, V | 1 |
| Cano-Europa, E | 1 |
| Hernández-García, A | 1 |
| Ortiz-Butrón, R | 1 |
| Primavera, A | 1 |
| Audenino, D | 1 |
| Cocito, L | 1 |
9 other studies available for diazepam and Encephalopathy, Toxic
| Article | Year |
|---|---|
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Novel neurosteroid pregnanolone pyroglutamate suppresses neurotoxicity syndrome induced by tetramethylenedisulfotetramine but is ineffective in a rodent model of infantile spasms.
Topics: Animals; Diazepam; Glutamic Acid; N-Methylaspartate; Neurosteroids; Neurotoxicity Syndromes; Pregnan | 2023 |
Acute administration of diazepam or midazolam minimally alters long-term neuropathological effects in the rat brain following acute intoxication with diisopropylfluorophosphate.
Topics: Animals; Brain Diseases; Cholinesterase Inhibitors; Diazepam; GABA Modulators; Gliosis; Isoflurophat | 2020 |
Benzodiazepine-refractory status epilepticus, neuroinflammation, and interneuron neurodegeneration after acute organophosphate intoxication.
Topics: Animals; Antidotes; Brain; Diazepam; Disease Models, Animal; Humans; Interneurons; Male; Nerve Agent | 2018 |
Developmental neurotoxicity of pyrethroid insecticides in zebrafish embryos.
Topics: Abnormalities, Drug-Induced; Aminobenzoates; Animals; Biological Assay; Craniofacial Abnormalities; | 2010 |
Suspected acute meperidine toxicity in a dog.
Topics: Adjuvants, Anesthesia; Anesthesia, General; Animals; Anticonvulsants; Central Nervous System; Diazep | 2010 |
Protection against soman-induced neuropathology and respiratory failure: a comparison of the efficacy of diazepam and avizafone in guinea pig.
Topics: Animals; Anticonvulsants; Atropine; Brain; Cholinesterase Inhibitors; Diazepam; Dipeptides; Electroe | 2006 |
Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity.
Topics: Acrylamide; Animals; Anticonvulsants; Brain Neoplasms; Caffeine; Calcium Channels; Central Nervous S | 2007 |
Hippocampus and amygdala neurotoxicity produced by systemic lidocaine in adult rats.
Topics: Amygdala; Animals; Anti-Arrhythmia Agents; Anticonvulsants; Calcium; Cell Count; Cell Size; Diazepam | 2007 |
Ifosfamide encephalopathy and nonconvulsive status epilepticus.
Topics: Adult; Anticonvulsants; Antineoplastic Agents, Alkylating; Diazepam; Electroencephalography; Epileps | 2002 |