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diazepam and Dystonia

diazepam has been researched along with Dystonia in 28 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Dystonia: An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)

Research Excerpts

ExcerptRelevanceReference
"We have observed two cases of chlorpromazine-induced neuroleptic malignant syndrome (NMS); both were transiently responsive to intravenous diazepam challenge, but not to blind placebo or amyobarbitol."9.05Chlorpromazine-induced neuroleptic malignant syndrome and its response to diazepam. ( Lew, TY; Tollefson, G, 1983)
"Fourteen patients with spasmodic torticollis and other segmental dystonic syndromes, who were refractory to previous forms of therapy, were selected for treatment with drugs intended to elevate brain gamma-aminobutyric acid (GABA) levels."5.26Effect of L-glutamine and isoniazid on torticollis and segmental dystonia. ( Korein, J; Kupersmith, M; Levidow, L; Lieberman, A, 1981)
"We have observed two cases of chlorpromazine-induced neuroleptic malignant syndrome (NMS); both were transiently responsive to intravenous diazepam challenge, but not to blind placebo or amyobarbitol."5.05Chlorpromazine-induced neuroleptic malignant syndrome and its response to diazepam. ( Lew, TY; Tollefson, G, 1983)
" Oral administration of high dosage of anticholinergic drugs is firstly recommended for the treatment of dystonia."2.41[Medical treatment of dystonia]. ( Kachi, T, 2001)
"Isolated dystonia or spasticity was infrequently seen, with a mixed picture of dystonia and spasticity ± choreoathetosis identified in 194/275 (70."1.51Pharmacological management of abnormal tone and movement in cerebral palsy. ( Amin, S; Basu, A; Cadwgan, J; Crowe, B; DeAlwis, Y; Devlin, A; Kumar, R; Lodh, R; Lumsden, DE; Lundy, CT; Mordekar, SR; Smith, M, 2019)
"Case note review of 278 children with dystonia referred to our service."1.43Medication use in childhood dystonia. ( Kaminska, M; Lin, JP; Lumsden, DE; Tomlin, S, 2016)
"One patient had hemifacial spasm."1.35Syndrome of fixed dystonia in adolescents--short term outcome in 4 cases. ( Colomer, J; Fernández-Alvarez, E; Galvan, M; Jardine, PE; Lingappa, L; López-Casas, J; Majumdar, A; Poo, P; Short, C, 2009)
"Primary generalized dystonia (PGD) associated with the early-onset generalized dystonia gene (DYT1) can cause severe disability, compromising an individual's ability to perform activities of daily living."1.32Bilateral globus pallidus internus deep brain stimulation therapy for primary generalized dystonia. ( Abramovitch, AI; Charles, PD; Covington, CD; Davis, TL; Gill, CE; Konrad, PE; Newman, WJ; Padaliya, BB, 2004)
"Attacks of sustained dystonia of the limbs and trunk can be initiated by handling or mild environmental stimuli (e."1.29Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters. ( Löscher, W; Richter, A, 1993)
"Diazepam treatment significantly reduced the frequency of dystonic movements in the mutant."1.27Alterations in cerebellar glutamic acid decarboxylase (GAD) activity in a genetic model of torsion dystonia (rat). ( Beales, M; Gordon, JH; Lorden, JF; Oltmans, GA, 1984)
"Fourteen patients with spasmodic torticollis and other segmental dystonic syndromes, who were refractory to previous forms of therapy, were selected for treatment with drugs intended to elevate brain gamma-aminobutyric acid (GABA) levels."1.26Effect of L-glutamine and isoniazid on torticollis and segmental dystonia. ( Korein, J; Kupersmith, M; Levidow, L; Lieberman, A, 1981)
"Thirteen patients with acute dystonia and extrapyramidal symptoms as a result of drug intoxication are reported."1.26Treatment with diazepam of children with drug-induced extrapyramidal symptoms. ( Rainier-Pope, CR, 1979)

Research

Studies (28)

TimeframeStudies, this research(%)All Research%
pre-199014 (50.00)18.7374
1990's8 (28.57)18.2507
2000's4 (14.29)29.6817
2010's2 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lumsden, DE2
Crowe, B1
Basu, A1
Amin, S1
Devlin, A1
DeAlwis, Y1
Kumar, R1
Lodh, R1
Lundy, CT1
Mordekar, SR1
Smith, M1
Cadwgan, J1
Kaminska, M1
Tomlin, S1
Lin, JP1
Majumdar, A1
López-Casas, J1
Poo, P1
Colomer, J1
Galvan, M1
Lingappa, L1
Short, C1
Jardine, PE1
Fernández-Alvarez, E1
Kachi, T1
Hamann, M1
Meisler, MH1
Richter, A3
Padaliya, BB1
Davis, TL1
Newman, WJ1
Konrad, PE1
Covington, CD1
Gill, CE1
Abramovitch, AI1
Charles, PD1
Dahiya, U1
Noronha, P1
Kaminer, Y1
Modai, I1
Lew, TY1
Tollefson, G1
Oltmans, GA1
Beales, M1
Lorden, JF1
Gordon, JH1
Korein, J1
Lieberman, A1
Kupersmith, M1
Levidow, L1
Bryant, SG1
Löscher, W4
Rosebush, PI1
Mazurek, MF1
Pina, MA1
Ara, JR1
Remírez, A1
Castiella, J1
Gruber Gikovate, C1
Zirretta, JC1
Ferreira Bezerra, JM1
Canedo de Magalhães, G1
Barkovich, AJ1
Chong, SA1
Remington, G1
Tan, CH1
Gagrat, D1
Hamilton, J1
Belmaker, RH1
Rainier-Pope, CR1
Di Monda, V1
Fazzari, G1
Callea, L1
Adlmici, G1
Ranganathan, G1
Nammalwar, BR1
Somu, N1
Satyamurthy, V1
Sivashanmugavel, S1
Balagopal Raju, V1
Fredow, G2
Mets, B1
Fisher, JE1
Schmidt, D1
Hönack, D1
Iturrian, WB1
Reddy, RV1
Siemers, ER1
Achumba, JI1
Ette, EI1
Thomas, WO1
Essien, EE1
Godbout, R1
Montplaisir, J1
Rouleau, I1

Reviews

1 review available for diazepam and Dystonia

ArticleYear
[Medical treatment of dystonia].
    Rinsho shinkeigaku = Clinical neurology, 2001, Volume: 41, Issue:12

    Topics: Cholinergic Antagonists; Clonazepam; Diazepam; Dopamine Antagonists; Dystonia; Humans; Levodopa; Tor

2001

Trials

1 trial available for diazepam and Dystonia

ArticleYear
Chlorpromazine-induced neuroleptic malignant syndrome and its response to diazepam.
    Biological psychiatry, 1983, Volume: 18, Issue:12

    Topics: Brain; Chlorpromazine; Diazepam; Dopamine; Dyskinesia, Drug-Induced; Dystonia; Female; Fever; gamma-

1983

Other Studies

26 other studies available for diazepam and Dystonia

ArticleYear
Pharmacological management of abnormal tone and movement in cerebral palsy.
    Archives of disease in childhood, 2019, Volume: 104, Issue:8

    Topics: Adolescent; Baclofen; Botulinum Toxins; Cerebral Palsy; Child; Child Health Services; Child, Prescho

2019
Medication use in childhood dystonia.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2016, Volume: 20, Issue:4

    Topics: Adolescent; Antiparkinson Agents; Baclofen; Child; Chloral Hydrate; Cohort Studies; Diazepam; Drug-R

2016
Syndrome of fixed dystonia in adolescents--short term outcome in 4 cases.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2009, Volume: 13, Issue:5

    Topics: Adolescent; Anxiety; Autonomic Nerve Block; Bites and Stings; Botulinum Toxins, Type A; Complex Regi

2009
Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia.
    Experimental neurology, 2003, Volume: 184, Issue:2

    Topics: Animals; Anti-Dyskinesia Agents; Anticonvulsants; Biperiden; Brain; Diazepam; Disease Models, Animal

2003
Bilateral globus pallidus internus deep brain stimulation therapy for primary generalized dystonia.
    Tennessee medicine : journal of the Tennessee Medical Association, 2004, Volume: 97, Issue:7

    Topics: Botulinum Toxins; Child; Deep Brain Stimulation; Diazepam; Dystonia; Globus Pallidus; Humans; Male;

2004
Drug-induced acute dystonic reactions in children. Alternatives to diphenhydramine therapy.
    Postgraduate medicine, 1984, Volume: 75, Issue:5

    Topics: Antipsychotic Agents; Basal Ganglia Diseases; Benztropine; Child; Child, Preschool; Creatine Kinase;

1984
Parenteral abuse of diazepam: a case report.
    Drug and alcohol dependence, 1984, Volume: 14, Issue:1

    Topics: Adult; Diazepam; Dystonia; Factitious Disorders; Humans; Injections, Intravenous; Male; Substance-Re

1984
Alterations in cerebellar glutamic acid decarboxylase (GAD) activity in a genetic model of torsion dystonia (rat).
    Experimental neurology, 1984, Volume: 85, Issue:1

    Topics: Animals; Brain; Cerebellum; Diazepam; Disease Models, Animal; Dystonia; Glutamate Decarboxylase; His

1984
Effect of L-glutamine and isoniazid on torticollis and segmental dystonia.
    Annals of neurology, 1981, Volume: 10, Issue:3

    Topics: Adult; Diazepam; Drug Therapy, Combination; Dystonia; Glutamine; Humans; Isoniazid; Middle Aged; Pyr

1981
Street drug misrepresentation.
    JAMA, 1980, Nov-14, Volume: 244, Issue:19

    Topics: Adult; Diazepam; Drug-Related Side Effects and Adverse Reactions; Dystonia; Haloperidol; Humans; Ill

1980
(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters.
    European journal of pharmacology, 1994, Nov-03, Volume: 264, Issue:3

    Topics: Analgesics; Animals; Benzoxazines; Cricetinae; Diazepam; Disease Models, Animal; Dose-Response Relat

1994
Do benzodiazepines modify the incidence of neuroleptic-induced dystonia?
    The American journal of psychiatry, 1993, Volume: 150, Issue:3

    Topics: Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Diazepam; Dystonia; Humans; Schizophrenia

1993
Alterations in pharmacological sensitivity of GABAergic but not dopaminergic and glutamatergic systems during ontogenesis in dystonic mutant hamsters.
    European journal of pharmacology, 1993, Jan-26, Volume: 231, Issue:1

    Topics: Aging; Aminooxyacetic Acid; Animals; Cricetinae; Diazepam; Dopamine Antagonists; Dystonia; Mesocrice

1993
Verapamil and acute dystonia.
    Journal of clinical pharmacy and therapeutics, 1998, Volume: 23, Issue:1

    Topics: Adult; Anti-Arrhythmia Agents; Diazepam; Dystonia; Female; Humans; Injections, Intravenous; Muscle R

1998
Transient globus pallidus T1 shortening associated with polycythaemia and dystonia.
    Neuroradiology, 1999, Volume: 41, Issue:4

    Topics: Basal Ganglia; Cerebellum; Child, Preschool; Diazepam; Dystonia; Female; Globus Pallidus; Humans; Im

1999
Risperidone treatment of tardive dyskinesia and dystonia.
    The Journal of clinical psychiatry, 1999, Volume: 60, Issue:5

    Topics: Antipsychotic Agents; Diazepam; Dopamine Antagonists; Drug Administration Schedule; Drug Therapy, Co

1999
Intravenous diazepam in the treatment of neuroleptic-induced acute dystonia and akathisia.
    The American journal of psychiatry, 1978, Volume: 135, Issue:10

    Topics: Acute Disease; Akathisia, Drug-Induced; Antipsychotic Agents; Diazepam; Dyskinesia, Drug-Induced; Dy

1978
Treatment with diazepam of children with drug-induced extrapyramidal symptoms.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1979, Mar-03, Volume: 55, Issue:9

    Topics: Acute Disease; Child, Preschool; Diazepam; Dystonia; Female; Humans; Infant; Male; Parkinson Disease

1979
[On a muscular dystony case from manganism. Therapeutic clinic considerations (author's transl)].
    L'Ateneo parmense. Acta bio-medica : organo della Societa di medicina e scienze naturali di Parma, 1979, Volume: 50, Issue:5-6

    Topics: Benserazide; Diazepam; Dystonia; Haloperidol; Humans; Hydrazines; Levodopa; Male; Manganese; Middle

1979
Preliminary study of diazepam in drug induced dystonia in children.
    Indian pediatrics, 1978, Volume: 15, Issue:9

    Topics: Child; Diazepam; Dystonia; Humans; Injections, Intravenous

1978
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
    European journal of pharmacology, 1991, Jan-10, Volume: 192, Issue:2

    Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin

1991
Acute dystonia after alfentanil in untreated Parkinson's disease.
    Anesthesia and analgesia, 1991, Volume: 72, Issue:4

    Topics: Aged; Alfentanil; Diazepam; Dystonia; Female; Humans; Parkinson Disease; Preanesthetic Medication

1991
The sz mutant hamster: a genetic model of epilepsy or of paroxysmal dystonia?
    Movement disorders : official journal of the Movement Disorder Society, 1989, Volume: 4, Issue:3

    Topics: Animals; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; Electroencephalography; Electromyog

1989
Dystonia: therapy with high dosage anticholinergic medication.
    Indiana medicine : the journal of the Indiana State Medical Association, 1987, Volume: 80, Issue:6

    Topics: Diazepam; Drug Therapy, Combination; Dystonia; Humans; Male; Middle Aged; Parasympatholytics; Phenot

1987
Chloroquine-induced acute dystonic reactions in the presence of metronidazole.
    Drug intelligence & clinical pharmacy, 1988, Volume: 22, Issue:4

    Topics: Adult; Basal Ganglia Diseases; Chloroquine; Diazepam; Drug Interactions; Dystonia; Female; Humans; M

1988
Hypnogenic paroxysmal dystonia: epilepsy or sleep disorder? A case report.
    Clinical EEG (electroencephalography), 1985, Volume: 16, Issue:3

    Topics: Adult; Carbamazepine; Diazepam; Dystonia; Epilepsy; Humans; Male; Sleep; Sleep Wake Disorders; Syndr

1985