diazepam has been researched along with Disease Models, Animal in 488 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The main site of action of diazepam, as with other benzodiazepines, is at the GABA(A) receptor, although it has been suggested that some of the potentially beneficial actions of diazepam in nerve agent poisoning are mediated through other means." | 8.82 | The role of diazepam in the treatment of nerve agent poisoning in a civilian population. ( Marrs, TC, 2004) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 8.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 8.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| " The present study has been designed to evaluate the neuroprotective effect of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice." | 8.02 | Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations. ( Alfuraih, BS; Alsuhaibani, NA; Elsayed, AM; Mahmoud, RH; Nadwa, EH; Rashed, LA; Said, ES, 2021) |
| " Therefore, we propose a hypothesis that diazepam monotherapy or diazepam-ketamine dual therapy could terminate seizures and reduce mortality in the SE model at different time points during ongoing SE." | 8.02 | Diazepam Monotherapy or Diazepam-Ketamine Dual Therapy at Different Time Points Terminates Seizures and Reduces Mortality in a Status Epilepticus Animal Model. ( Cao, X; Li, Z; Wang, Y; Yu, J; Zhou, R, 2021) |
| " The seizures were induced with pentylenetetrazole (PTZ) intraperitoneally at 170 mg/kg, and diazepam (DZP) was used as the control anticonvulsant (2 mg/kg, oral); PA was tested at 10, 50, and 100 mg/kg orally." | 8.02 | Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures. ( Borges, RS; Carvalho, JCT; da Silva Hage-Melim, LI; de Melo, EL; Hu, X; Matias Pereira, AC; Sánchez-Ortíz, BL, 2021) |
| "diazepam attenuated pain induced by dentin hypersensitivity in rats exposed to stress." | 7.91 | Diazepam as attenuator of pain induced by dentin hypersensitivity in rats exposed to stress. ( Barbosa Suffredini, I; Bernardi, MM; Coury Saraceni, CH; Kabadayan, F; Tonetti Ciaramicoli, M, 2019) |
| "Diazepam could regulate immune system and inflammation, which might be a potential therapeutic agent for pulmonary fibrosis in clinic." | 7.91 | Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABA ( Bo, F; Deng, M; Li, Y; Song, D; Tang, X, 2019) |
| " Lobeline increased the latency to the first seizure and decreased the percentage of seizures in a similar way as diazepam, used as control." | 7.88 | DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism. ( Boaretto, FBM; da Costa E Silva, LD; da Silva, LL; Hoffmann, C; Morás, AM; Moura, DJ; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Steffens, LR, 2018) |
| "Part 1: Anxiety at 3 hours was significantly lower following minocycline (20 mg/kg i." | 7.88 | Minocycline in Alcohol Withdrawal Induced Anxiety and Alcohol Relapse in Rats. ( Gajbhiye, SV; Petare, A; Potey, AV; Shankar, A; Tripathi, RK, 2018) |
| "To evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE)." | 7.85 | Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. ( Klitgaard, H; Matagne, A; Niquet, J; Suchomelova, L; Thompson, K; Wasterlain, C, 2017) |
| "CD1 and CD2 characterized as bergenin, exhibited significant antianxiety activity at 80mg/kg, po which was statistically comparable to that of diazepam (2mg/kg, po)." | 7.85 | Antianxiety activity guided isolation and characterization of bergenin from Caesalpinia digyna Rottler roots. ( Kumar, A; Sharma, A; Singh, J, 2017) |
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 7.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 7.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 7.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| "Levetiracetam has been reported to be well tolerated and effective in status epilepticus (SE) refractory to benzodiazepine." | 7.79 | The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus. ( Choi, HC; Kang, TC; Kim, JE; Kim, YI; Lee, DS; Ryu, HJ; Song, HK, 2013) |
| "Experiments were conducted to evaluate the effects of transcranial focal electrical stimulation (TFS) applied via tripolar concentric ring electrodes, alone and associated with a sub-effective dose of diazepam (DZP) on the expression of status epilepticus (SE) induced by lithium-pilocarpine (LP) and subsequent neuronal damage in the hippocampus." | 7.79 | Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats. ( Besio, W; Cuellar-Herrera, M; Luna-Munguia, H; Orozco-Suárez, S; Rocha, L, 2013) |
| "The anxiolytic-like effects of topiramate were assessed during several estrous cycle phases in Wistar rats tested in two animal models of anxiety-like behavior." | 7.79 | Estrous cycle variation in anxiolytic-like effects of topiramate in Wistar rats in two animal models of anxiety-like behavior. ( Jaramillo, MT; Molina-Hernández, M; Olivera-López, JI; Téllez-Alcántara, NP, 2013) |
| "Here we examined the effects of Ro 64-6198 on unconditioned conflict anxiety using stimuli with different salience and on regulation of autonomic reactivity and compared these to the effects of benzodiazepine receptor agonists." | 7.78 | Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair. ( Goeldner, C; Prinssen, EP; Spooren, W; Wichmann, J, 2012) |
| "Injection of the seaweed toxin kainic acid (KA) in rats induces a severe status epilepticus initiating complex neuropathological changes in limbic brain areas and subsequently spontaneous recurrent seizures." | 7.78 | Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex. ( Drexel, M; Preidt, AP; Sperk, G, 2012) |
| ") and seizures terminated after 2 h with diazepam (10 mg/kg, i." | 7.78 | N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses. ( Beamer, E; Otahal, J; Sills, GJ; Thippeswamy, T, 2012) |
| "The aim of present research was to study, by means of descriptive and multivariate t-pattern analyses, the effects of the reference anxiolytic drug diazepam (DZP) on temporal structure of a rat's anxiety-related behavior in HB." | 7.77 | T-pattern analysis of diazepam-induced modifications on the temporal organization of rat behavioral response to anxiety in hole board. ( Casarrubea, M; Crescimanno, G; Magnusson, MS; Sorbera, F, 2011) |
| "In the present study, the effects of intraamygdalar administrations of melatonin (1 and 100μg/kg), saline and diazepam on the anxiety-like behavior and spatial memory performance in pinealectomized and sham-pinealectomized Wistar rats were investigated." | 7.77 | The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats. ( Coşkun, H; Gündüz, B; Karakaş, A; Kaya, A; Kücük, A, 2011) |
| "The aim of the present study was to investigate the role of GABAergic and nitriergic modulation in the antianxiety effect of thymoquinone, a major constituent of Nigella sativa, in mice under unstressed and stressed conditions." | 7.77 | Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels. ( Dhingra, D; Gilhotra, N, 2011) |
| "The anti-inflammatory activity of amitriptyline, diazepam and a new, Russian tranquilizer mebicar was studied in a wide range of therapeutic doses on carrageenan-induced paw edema in rats." | 7.77 | [Anti-inflammatory effects of amitriptyline, diazepam and mebicar using model of acute carrageenan-induced paw edema in rats]. ( Kaziakhmetova, VN; Valeeva, IKh; Ziganshina, LE, 2011) |
| "Benzodiazepines such as diazepam may fail to effectively treat status epilepticus because benzodiazepine-sensitive GABA(A) receptors are progressively internalized with continued seizure activity." | 7.76 | Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466. ( Fritsch, B; Joelle Donofrio, J; Rogawski, MA; Stott, JJ, 2010) |
| "In the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated." | 7.76 | The control of kainic acid-induced status epilepticus. ( Clinckers, R; Massie, A; Michotte, Y; Smolders, I; Vermoesen, K, 2010) |
| " We have shown recently that topiramate (TPM) dose-dependently protects hippocampal CA1 and CA3 neurons during initial status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibition of mitochondrial transition pore opening." | 7.74 | Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. ( Elger, CE; Frisch, C; Helmstaedter, C; Kudin, AP; Kunz, WS, 2007) |
| "By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200mg/kg), SIB1893 (from 25 to 100mg/kg), MPEP (from 25 to 100mg/kg) injected at 1 or 2h during PISE were ineffective in controlling status epilepticus (SE)." | 7.74 | Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus. ( Chen, PM; Lee, WL; Tang, FR; Tang, YC; Tsai, MC, 2007) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 7.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| "This study evaluated the effectiveness of fosphenytoin as a single or adjunctive anticonvulsant treatment for nerve agent-induced status epilepticus." | 7.72 | Effects of fosphenytoin on nerve agent-induced status epilepticus. ( Benjamin, A; McDonough, JH; McMonagle, JD; Rowland, T; Shih, TM, 2004) |
| "Previously, it was shown that subchronic application of the NMDA receptor antagonist ketamine (Ket) induces schizophrenia-related alterations, e." | 7.72 | Ketamine-induced changes in rat behaviour: a possible animal model of schizophrenia. Test of predictive validity. ( Becker, A; Grecksch, G, 2004) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 7.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety." | 7.71 | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. ( Kurasawa, M; Nakamura, K, 2001) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 7.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "To examine the putative seizure-protective properties of felbamate in an animal model of self-sustaining status epilepticus (SSSE)." | 7.70 | Felbamate in experimental model of status epilepticus. ( Baldwin, RA; Mazarati, AM; Sofia, RD; Wasterain, CG, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 7.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| "The effect of nimodipine alone and in combination with diazepam or phenytoin was tested in the electroshock-induced mouse model of status epilepticus." | 7.70 | Anticonvulsant effect of nimodipine alone and in combination with diazepam and phenytoin in a mouse model of status epilepticus. ( Khosla, P; Pandhi, P, 2000) |
| "The profile of action of ondansetron was assessed in a novel animal model of anxiety." | 7.69 | Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model. ( Kulkarni, SK; Roychoudhury, M, 1997) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 7.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 7.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 7.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "Harmine, a hallucinogen with potent monoamine oxidase inhibitory properties, induced abnormal behavior, including tremor, scratching, head twitch and cage biting, in the mouse." | 7.66 | Pharmacological characteristics of abnormal behavior induced by harmine with special reference to tremor in mice. ( Fujiwara, M; Hashimoto, Y; Kataoka, Y; Kawanishi, K; Ueki, S, 1981) |
| " Novel data indicated that neither FSL nor FRL rats exhibited alterations in swim test immobility following chronic administration of the psychomotor stimulant amphetamine (2 mg/kg) and the anticholinergic scopolamine (2 mg/kg), which typically reduce immobility after acute administration." | 6.39 | Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression. ( Janowsky, DS; Overstreet, DH; Pucilowski, O; Rezvani, AH, 1995) |
| "Quercetin treatment was found to significantly reduce anxiety-like behaviors in mTBI-induced mice." | 5.51 | Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury. ( Ghorbanihaghjo, A; Kosari-Nasab, M; Mesgari-Abbasi, M; Salari, AA; Shokouhi, G, 2019) |
| "Diazepam-resistant SE was induced in adult mice fed with standard or ketogenic diet or in cannabinoid receptor type 1 (CB1) receptor knock-out mice." | 5.48 | Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. ( Butler, CR; Guilmette, E; Pauletti, A; Piro, JR; Porcu, L; Rizzi, M; Salamone, A; Samad, TA; Sheehan, MJ; Terrone, G; Vezzani, A; Villa, BR, 2018) |
| "Riluzole is an antiglutamatergic agent and the only drug to offer some effect on the life expectancy of ALS patients." | 5.46 | Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of amyotrophic lateral sclerosis substantiated by riluzole and diazepam. ( Andreasen, SR; Christensen, TB; Holm, MM; Lundbye, CJ; Schmitt-John, T; Thielsen, KD, 2017) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Diazepam treated animals showed significant alterations in the neurobehavior and neuro-histoarchitecture, which were improved after X-irradiation." | 5.43 | Low dose X-irradiation mitigates diazepam induced depression in rat brain. ( Dhawan, DK; Kaur, A; Singla, N, 2016) |
| "Curcumin is a biologically active phytochemical presents in turmeric and has pharmacological actions that benefit patients with depression and anxiety." | 5.42 | The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. ( Li, J; Pan, J; Wang, R; Wu, S; Xie, X; Xu, Y; Yu, X; Yu, Y; Zheng, L, 2015) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 5.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 5.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| "Tetramethylenedisulfotetramine (TETS) is a potent convulsant GABAA receptor blocker." | 5.42 | Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. ( Austin, AT; Bruun, DA; Cao, Z; Hammock, BD; Hulsizer, S; Inceoglu, B; Lein, PJ; Pessah, IN; Rogawski, MA; Tancredi, DJ; Vito, ST, 2015) |
| "Trials of novel compounds for the treatment of schizophrenia are typically tested in patients following brief withdrawal of ongoing medication despite known long-term changes in the dopamine (DA) system following chronic antipsychotic drug therapy." | 5.40 | Prior antipsychotic drug treatment prevents response to novel antipsychotic agent in the methylazoxymethanol acetate model of schizophrenia. ( Cook, JM; Gill, KM; Grace, AA; Poe, MM, 2014) |
| "Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations." | 5.40 | Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Deshpande, LS; Phillips, KF, 2014) |
| "Tetramethylenedisulfotetramine (TETS) is a potent convulsant poison for which there is currently no approved antidote." | 5.40 | Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. ( Austin, AT; Banks, CN; Bruun, DA; Hammock, BD; Inceoglu, B; Lein, PJ; Rogawski, MA; Tancredi, DJ; Vito, ST; Zolkowska, D, 2014) |
| "Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs." | 5.40 | Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 5.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| " The doses of modulators were selected on the basis of dose-response studies." | 5.39 | Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam. ( Bhutada, P; Deshmukh, P; Dixit, P; Kaulaskar, S; Thakur, K, 2013) |
| "Gabapentin was used to provide an anxiolytic effect on drug-free days." | 5.38 | Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats. ( Açikmeşe, B; Enginar, N; Hatipoğlu, I; Haznedar, S, 2012) |
| "Diazepam (2mg/kg) was also tested at three times during the 24-h day in the elevated plus maze: at the beginning and end of the lights-on period (Zeitgeber times 23 and 11, respectively) and once in the dark just before the room lights came on (Zeitgeber time 20)." | 5.37 | The benzodiazepine diazepam demonstrates the usefulness of Syrian hamsters as a model for anxiety testing: evaluation of other classes of anxiolytics in comparison to diazepam. ( Batista, N; Delagrange, P; Gannon, RL; Hester, I; Huntley, C; Lungwitz, E; Millan, MJ; Peacock, A, 2011) |
| "The treatment with haloperidol worsened the adverse effects of chronic social stress having effects similar to stress on reward and motivation-related behaviours." | 5.35 | Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam. ( Abumaria, N; Flügge, G; Fuchs, E; Havemann-Reinecke, U; Hiemke, C; Rüther, E; Rygula, R; Zernig, G, 2008) |
| "In addition, convulsions induced by lithium-methomyl treatment were associated with widespread neurodegeneration of limbic structures." | 5.34 | Lithium-methomyl induced seizures in rats: a new model of status epilepticus? ( Blaszczak, P; Calderazzo, L; Cavalheiro, EA; Dekundy, A; Kaminski, RM; Parada-Turska, J; Turski, WA, 2007) |
| "Levetiracetam (LEV) is a structurally novel antiepileptic drug (AED) which has demonstrated a broad spectrum of anticonvulsant activities both in experimental and clinical studies." | 5.34 | Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats. ( Bethmann, K; Brandt, C; Fedrowitz, M; Gastens, AM; Glien, M; Löscher, W; Potschka, H; Volk, HA, 2007) |
| "If epilepsy developed, the seizures were less frequent in DZP-treated animals compared to the vehicle group (median 16." | 5.33 | Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat. ( Kharatishvili, I; Lukasiuk, K; Narkilahti, S; Nissinen, J; Pitkänen, A, 2005) |
| "Pre-treatment with diazepam, 10 and 20mg/kg, and chlormethiazole, 50 and 100mg/kg, attenuated the development of hyperthermia." | 5.32 | Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Takano, K; Yoshino, T, 2003) |
| "Numbers of ictal events (seizure) and latency to the first event were reduced by prophylactic DZP." | 5.32 | Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model. ( Anschel, DJ; Fisher, RS; Ortega, E, 2004) |
| "Using an amygdala-kindled seizure paradigm, we evaluated the acute and chronic anticonvulsant effects of lamotrigine (LTG)." | 5.31 | Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam. ( Heynen, T; Krupp, E; Li, XL; Post, RM; Weiss, SR, 2000) |
| "(-)-Baclofen was the only one of the three compounds tested that reversed in a dose-dependent manner the effects of tone exposure on both the amplitude of the click-evoked potentials recorded from the IC and on measures of the changes in temporal integration based on these potentials." | 5.29 | Effects of (-)-baclofen, clonazepam, and diazepam on tone exposure-induced hyperexcitability of the inferior colliculus in the rat: possible therapeutic implications for pharmacological management of tinnitus and hyperacusis. ( Møller, AR; Szczepaniak, WS, 1996) |
| "Evidence suggests that soman-induced convulsions may be associated with postexposure brain neuropathology." | 5.28 | Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. ( Capacio, BR; Koviak, TA; Shih, TM, 1991) |
| "Diazepam treatment alleviates in the first session aversion towards open space and hight in the elevated plus-maze only in the genetically hypertensive rats of both sexes and in the normotensive males." | 5.28 | Animal model of anxiety: effect of acute diazepam treatment in the older adult genetically hypertensive rats of Koletsky type and in the older adult rats of Wistar strain. ( Golda, V; Petr, R, 1989) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 5.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "The main site of action of diazepam, as with other benzodiazepines, is at the GABA(A) receptor, although it has been suggested that some of the potentially beneficial actions of diazepam in nerve agent poisoning are mediated through other means." | 4.82 | The role of diazepam in the treatment of nerve agent poisoning in a civilian population. ( Marrs, TC, 2004) |
| "Benzodiazepine withdrawal, spontaneous or precipitated by the receptor antagonist, flumazenil, produces anxiety that can be measured in animal models." | 4.78 | The benzodiazepines: anxiolytic and withdrawal effects. ( Little, HJ, 1991) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 4.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 4.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| " We validated this as anxiety-like behaviors with diazepam reducing, and caffeine increasing the time spent in the bottom of the novel environment." | 4.12 | The larval diving response (LDR): Validation of an automated, high-throughput, ecologically relevant measure of anxiety-related behavior in larval zebrafish (Danio rerio). ( Fontana, BD; Parker, MO, 2022) |
| " The present study has been designed to evaluate the neuroprotective effect of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice." | 4.02 | Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations. ( Alfuraih, BS; Alsuhaibani, NA; Elsayed, AM; Mahmoud, RH; Nadwa, EH; Rashed, LA; Said, ES, 2021) |
| " Therefore, we propose a hypothesis that diazepam monotherapy or diazepam-ketamine dual therapy could terminate seizures and reduce mortality in the SE model at different time points during ongoing SE." | 4.02 | Diazepam Monotherapy or Diazepam-Ketamine Dual Therapy at Different Time Points Terminates Seizures and Reduces Mortality in a Status Epilepticus Animal Model. ( Cao, X; Li, Z; Wang, Y; Yu, J; Zhou, R, 2021) |
| " The seizures were induced with pentylenetetrazole (PTZ) intraperitoneally at 170 mg/kg, and diazepam (DZP) was used as the control anticonvulsant (2 mg/kg, oral); PA was tested at 10, 50, and 100 mg/kg orally." | 4.02 | Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures. ( Borges, RS; Carvalho, JCT; da Silva Hage-Melim, LI; de Melo, EL; Hu, X; Matias Pereira, AC; Sánchez-Ortíz, BL, 2021) |
| " The present study was designed to investigate the effect of acute and chronic administration of thiamine alone and in combination with sub-effective dose of diazepam on pentylenetetrazole (PTZ)-induced tonic-clonic seizures in mice." | 3.91 | Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice. ( Abed, A; Alinejad, M; Banafshe, HR; Heydari, A; Mesdaghinia, A, 2019) |
| "diazepam attenuated pain induced by dentin hypersensitivity in rats exposed to stress." | 3.91 | Diazepam as attenuator of pain induced by dentin hypersensitivity in rats exposed to stress. ( Barbosa Suffredini, I; Bernardi, MM; Coury Saraceni, CH; Kabadayan, F; Tonetti Ciaramicoli, M, 2019) |
| "Diazepam could regulate immune system and inflammation, which might be a potential therapeutic agent for pulmonary fibrosis in clinic." | 3.91 | Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABA ( Bo, F; Deng, M; Li, Y; Song, D; Tang, X, 2019) |
| " Lobeline increased the latency to the first seizure and decreased the percentage of seizures in a similar way as diazepam, used as control." | 3.88 | DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism. ( Boaretto, FBM; da Costa E Silva, LD; da Silva, LL; Hoffmann, C; Morás, AM; Moura, DJ; Pereira, P; Pflüger, P; Picada, JN; Regner, GG; Steffens, LR, 2018) |
| "Part 1: Anxiety at 3 hours was significantly lower following minocycline (20 mg/kg i." | 3.88 | Minocycline in Alcohol Withdrawal Induced Anxiety and Alcohol Relapse in Rats. ( Gajbhiye, SV; Petare, A; Potey, AV; Shankar, A; Tripathi, RK, 2018) |
| " The aim of the present study was to explore the effect of a selective CB2 receptor agonist β-caryophyllene (BCP) in models of seizures and cognition in mice." | 3.88 | Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice. ( da Conceição Machado, K; de Carvalho Melo Cavalcante, AA; Gomes Júnior, AL; Momchilova, A; Tchekalarova, J; Tzoneva, R, 2018) |
| "We previously showed that nicotine evoked kinetic tremor by activating the inferior olive, which is implicated in the pathogenesis of essential tremor, via α7 nicotinic acetylcholine receptors." | 3.88 | Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents. ( Abe, K; Hashimura, M; Iha, HA; Iwai, C; Kato, M; Kawaji, S; Kawakita, K; Kunisawa, N; Ogawa, M; Ohno, Y; Shimizu, S, 2018) |
| "To evaluate acute and long-term effects of intravenous brivaracetam (BRV) and BRV + diazepam (DZP) combination treatment in a rat model of self-sustaining status epilepticus (SSSE)." | 3.85 | Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. ( Klitgaard, H; Matagne, A; Niquet, J; Suchomelova, L; Thompson, K; Wasterlain, C, 2017) |
| "CD1 and CD2 characterized as bergenin, exhibited significant antianxiety activity at 80mg/kg, po which was statistically comparable to that of diazepam (2mg/kg, po)." | 3.85 | Antianxiety activity guided isolation and characterization of bergenin from Caesalpinia digyna Rottler roots. ( Kumar, A; Sharma, A; Singh, J, 2017) |
| "Rutin is a bioflavonoid found in medicinal plants used to reduce anxiety." | 3.85 | The anxiolytic-like effect of rutin in rats involves GABAA receptors in the basolateral amygdala. ( Fernández-Guasti, A; González-Trujano, ME; Hernandez-Leon, A, 2017) |
| "Diazepam can reduce the excitability of lateral amygdala and eventually suppress the excitability of the auditory cortex in rats following salicylate treatment, indicating the regulating effect of lateral amygdala to the auditory cortex in the tinnitus procedure." | 3.83 | Diazepam reduces excitability of amygdala and further influences auditory cortex following sodium salicylate treatment in rats. ( Liu, J; Ma, F; Mao, L; Song, Y, 2016) |
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 3.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| "The pilocarpine rat model, in which status epilepticus (SE) leads to epilepsy with spontaneous recurrent seizures (SRS), is widely used to study the mechanisms of epileptogenesis and develop strategies for epilepsy prevention." | 3.81 | Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers. ( Brandt, C; Bröer, S; Klee, R; Löscher, W; Töllner, K, 2015) |
| " AP521 showed equal or more potent anxiolytic-like effects compared with diazepam, a benzodiazepine receptor agonist, or tandospirone, a partial 5-hydroxytryptamine (5-HT)1A receptor agonist, in three rat anxiety models; the Vogel-type conflict test, elevated plus maze test, and conditioned fear stress test." | 3.81 | The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. ( Hashimoto, S; Hattori, T; Kasahara, K; Kawakubo, H; Kawasaki, K; Nagatani, T; Nakazono, O; Takao, K; Tsujita, R, 2015) |
| " Diazepam produced a dose-dependent protection against 6-Hz seizures in control and pilocarpine mice, both at 2 weeks and 8 weeks after SE, but with a more pronounced increase in potency in post-SE animals at 2 weeks." | 3.81 | Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model. ( Kaminski, RM; Leclercq, K, 2015) |
| "The effects of mitragynine on anxiety-related behaviours in the open-field and elevated plus-maze tests were evaluated." | 3.80 | Anxiolytic-like effects of mitragynine in the open-field and elevated plus-maze tests in rats. ( Hazim, AI; Mansor, SM; Muzaimi, M; Parthasarathy, S; Ramanathan, S, 2014) |
| "Piperine produced significant antianxiety-like activity in unstressed and stressed mice." | 3.80 | Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice. ( Dhingra, D; Gilhotra, N, 2014) |
| "It was the aim of this study to determine the potential effect of walnut kernel extract (WKE) on experimentally induced seizures in rats and to evaluate the role of benzodiazepines and ethosuximide (ESM) within these pathways." | 3.80 | Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure. ( Asadi-Shekaari, M; Eslami, A; Joukar, S; Kalantaripour, T, 2014) |
| "Levetiracetam has been reported to be well tolerated and effective in status epilepticus (SE) refractory to benzodiazepine." | 3.79 | The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus. ( Choi, HC; Kang, TC; Kim, JE; Kim, YI; Lee, DS; Ryu, HJ; Song, HK, 2013) |
| "Experiments were conducted to evaluate the effects of transcranial focal electrical stimulation (TFS) applied via tripolar concentric ring electrodes, alone and associated with a sub-effective dose of diazepam (DZP) on the expression of status epilepticus (SE) induced by lithium-pilocarpine (LP) and subsequent neuronal damage in the hippocampus." | 3.79 | Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats. ( Besio, W; Cuellar-Herrera, M; Luna-Munguia, H; Orozco-Suárez, S; Rocha, L, 2013) |
| " This new method documented that seizures in the zebrafish EAST model were ameliorated by pentobarbitone, but not diazepam, validating its usefulness." | 3.79 | Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings. ( Bockenhauer, D; Kleta, R; Mahmood, F; Russell, C; Stanescu, HC; Zdebik, AA, 2013) |
| "The anxiolytic-like effects of topiramate were assessed during several estrous cycle phases in Wistar rats tested in two animal models of anxiety-like behavior." | 3.79 | Estrous cycle variation in anxiolytic-like effects of topiramate in Wistar rats in two animal models of anxiety-like behavior. ( Jaramillo, MT; Molina-Hernández, M; Olivera-López, JI; Téllez-Alcántara, NP, 2013) |
| "Here we examined the effects of Ro 64-6198 on unconditioned conflict anxiety using stimuli with different salience and on regulation of autonomic reactivity and compared these to the effects of benzodiazepine receptor agonists." | 3.78 | Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair. ( Goeldner, C; Prinssen, EP; Spooren, W; Wichmann, J, 2012) |
| "Catamenial epilepsy is caused by fluctuations in progesterone-derived GABA(A) receptor-modulating anticonvulsant neurosteroids, such as allopregnanolone, that play a significant role in the pathophysiology of epilepsy." | 3.78 | A mouse kindling model of perimenstrual catamenial epilepsy. ( Gangisetty, O; Gould, J; Reddy, DS, 2012) |
| " The endocannabinoid system is known to modulate seizure activity in several in vivo and in vitro models, and CB(1) -receptor activation is anticonvulsant in the rat pilocarpine model of acquired epilepsy (AE)." | 3.78 | Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain. ( Blair, RE; DeLorenzo, RJ; Nguyen, PT; Sayers, KW; Sim-Selley, LJ, 2012) |
| " Results from 2413 mice were evaluated for effects of sex, age, body weight, and latency between administration of atropine methyl bromide and pilocarpine." | 3.78 | Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Haney, MM, 2012) |
| "Injection of the seaweed toxin kainic acid (KA) in rats induces a severe status epilepticus initiating complex neuropathological changes in limbic brain areas and subsequently spontaneous recurrent seizures." | 3.78 | Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex. ( Drexel, M; Preidt, AP; Sperk, G, 2012) |
| "Melatonin (MLT) is a neurohormone known to be involved in the regulation of anxiety." | 3.78 | Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam. ( Bedini, A; Comai, S; Fraschini, F; Gobbi, G; Mor, M; Ochoa-Sanchez, R; Rainer, Q; Rivara, S; Spadoni, G; Tarzia, G, 2012) |
| ") and seizures terminated after 2 h with diazepam (10 mg/kg, i." | 3.78 | N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses. ( Beamer, E; Otahal, J; Sills, GJ; Thippeswamy, T, 2012) |
| " Systemic administration of the anxiolytic, diazepam, decreased the frequency of two behaviors associated with anxiety and defensiveness, upright and jump escape, as well as crawl under behavior." | 3.77 | A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice. ( Blanchard, DC; Blanchard, RJ; Bolivar, VJ; Defensor, EB; Pearson, BL; Pobbe, RL, 2011) |
| "The aim of present research was to study, by means of descriptive and multivariate t-pattern analyses, the effects of the reference anxiolytic drug diazepam (DZP) on temporal structure of a rat's anxiety-related behavior in HB." | 3.77 | T-pattern analysis of diazepam-induced modifications on the temporal organization of rat behavioral response to anxiety in hole board. ( Casarrubea, M; Crescimanno, G; Magnusson, MS; Sorbera, F, 2011) |
| "In the present study, the effects of intraamygdalar administrations of melatonin (1 and 100μg/kg), saline and diazepam on the anxiety-like behavior and spatial memory performance in pinealectomized and sham-pinealectomized Wistar rats were investigated." | 3.77 | The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats. ( Coşkun, H; Gündüz, B; Karakaş, A; Kaya, A; Kücük, A, 2011) |
| "We have shown previously that aberrant hippocampal (HPC) output underlies the dopamine (DA) dysfunction observed in the methylazoxymethanol acetate (MAM) developmental model of schizophrenia in the rodent." | 3.77 | A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia. ( Aras, S; Cook, JM; Gill, KM; Grace, AA; Lodge, DJ, 2011) |
| "Acute application of human ASCs-E before SE led to earlier attenuation of seizure spike activities after treatment with diazepam, reduction of BBB leakage, and inhibition of the development of epilepsy." | 3.77 | A cell-free extract from human adipose stem cells protects mice against epilepsy. ( Ban, JJ; Chu, K; Jeon, D; Jung, KH; Kang, KM; Kim, M; Kim, S; Lee, SK; Lee, ST; Roh, JK; Seo, JS; Won, CH, 2011) |
| "The aim of the present study was to investigate the role of GABAergic and nitriergic modulation in the antianxiety effect of thymoquinone, a major constituent of Nigella sativa, in mice under unstressed and stressed conditions." | 3.77 | Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels. ( Dhingra, D; Gilhotra, N, 2011) |
| "05) the onset and reduced the duration of the seizures induced by picrotoxin (5 mg/kg, i." | 3.77 | Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders. ( Adio, O; Fageyinbo, S; Sowemimo, AA, 2011) |
| "The anti-inflammatory activity of amitriptyline, diazepam and a new, Russian tranquilizer mebicar was studied in a wide range of therapeutic doses on carrageenan-induced paw edema in rats." | 3.77 | [Anti-inflammatory effects of amitriptyline, diazepam and mebicar using model of acute carrageenan-induced paw edema in rats]. ( Kaziakhmetova, VN; Valeeva, IKh; Ziganshina, LE, 2011) |
| "Benzodiazepines such as diazepam may fail to effectively treat status epilepticus because benzodiazepine-sensitive GABA(A) receptors are progressively internalized with continued seizure activity." | 3.76 | Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466. ( Fritsch, B; Joelle Donofrio, J; Rogawski, MA; Stott, JJ, 2010) |
| " Because early-life treatment with WAY-100,635 in Swiss-Webster mice reduced diazepam sensitivity and increased GABA(A)R alpha subunit levels in the prefrontal cortex and hippocampus, our data suggest a putative link between early-life disruption of the serotonergic system and the emergence of increased anxiety and decreased benzodiazepine responsivity at adult age." | 3.76 | Early-life blockade of 5-HT(1A) receptors alters adult anxiety behavior and benzodiazepine sensitivity. ( Groenink, L; Olivier, B; Oosting, RS; van Bogaert, MJ; Vinkers, CH, 2010) |
| "Using the four-plate test (FPT) model of anxiety in mice the potential anxiolytic-like effect of etifoxine was first to re-evaluate." | 3.76 | Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice. ( Bourin, M; Hascoët, M, 2010) |
| "Pre-treatment with GABA (40 mg/kg), diazepam, phenobarbital, AOAA and DABA abolished the appearance of seizures induced by 50 mg/kg (PhSe)₂ in rat pups." | 3.76 | Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system. ( Nogueira, CW; Prigol, M; Wilhelm, EA; Zeni, G, 2010) |
| "In the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated." | 3.76 | The control of kainic acid-induced status epilepticus. ( Clinckers, R; Massie, A; Michotte, Y; Smolders, I; Vermoesen, K, 2010) |
| "Diazepam-reduced experimental anxiety was paralleled by antinociceptive effects." | 3.76 | Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray. ( Fernández-Guasti, A; Jiménez-Velázquez, G; López-Muñoz, FJ, 2010) |
| "2 s, while chemical seizures were induced by intraperitoneal injection of pentylenetetrazole at its CD97 dose (97% convulsive dose for the clonic phase)." | 3.76 | Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice. ( Anitha, T; Gajera, K; Jayaraman, R; Joshi, VD; Ladani, K; Manisenthil, KT; Palei, NN, 2010) |
| " In acute study, seizures were induced by either pentylenetetrazole (PTZ) injection or maximal electroshock seizures, while in the chronic study, kindling was induced by injecting PTZ (30 mg/kg, s." | 3.76 | Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats. ( Arora, T; Banerjee, BD; Joshi, V; Mahajan, P; Mediratta, PK; Mehta, AK; Mehta, KD; Rathor, N; Sharma, AK; Sharma, KK, 2010) |
| "Diazepam decreased the number of LLC metastases in anxious losers, whereas in the winners and control mice, without anxiety state, diazepam was ineffective." | 3.75 | Limiting effect of diazepam on Lewis Lung carcinoma metastasis in anxious male mice. ( Kaledin, VI; Kudryavtseva, NN; Llnitskaya, SI; Nikolin, VP; Popova, NA; Smagin, DA, 2009) |
| "Flupirtine appears more effective than either of two commonly used antiepileptic drugs, phenobarbital and diazepam, in preventing and suppressing seizures in both the kainic acid and flurothyl models of symptomatic neonatal seizures." | 3.75 | A KCNQ channel opener for experimental neonatal seizures and status epilepticus. ( Brooks-Kayal, AR; Cooper, EC; Keating, JG; Lapides, DA; Raol, YH, 2009) |
| " Here, we describe a lesion that destroys the perforant path in CA3 after status epilepticus (SE) induced by pilocarpine injection in 8-week-old rats." | 3.74 | Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. ( Avoli, M; Baldelli, E; Biagini, G; Contri, MB; Gelosa, P; Guerrini, U; Longo, D; Ragsdale, DS; Sironi, L; Zini, I, 2008) |
| " We have shown recently that topiramate (TPM) dose-dependently protects hippocampal CA1 and CA3 neurons during initial status epilepticus in the rat pilocarpine model of temporal lobe epilepsy by inhibition of mitochondrial transition pore opening." | 3.74 | Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent. ( Elger, CE; Frisch, C; Helmstaedter, C; Kudin, AP; Kunz, WS, 2007) |
| " (PQS) was studied in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam." | 3.74 | Anxiolytic effect of saponins from Panax quinquefolium in mice. ( Wang, JH; Wei, XY; Wu, CF; Yang, JY, 2007) |
| "Continued usage of cocaine is determined by genetic, conditioned and homeostatic factors, while it is reinforced by drug-induced reward and the emotionally negative state of drug withdrawal, which includes anxiety." | 3.74 | Anxiogenic effects of cocaine withdrawal in zebrafish. ( Cabral, H; López-Patiño, MA; Yu, L; Zhdanova, IV, 2008) |
| "By intravenous administration of group I metabotropic glutamate receptor antagonists at 1 or 2h during pilocarpine induced status epilepticus (PISE), we showed that mGluR1 antagonists AIDA or LY367385 (at dosages ranging from 25 to 200mg/kg), mGluR5 antagonists SIB1757 (at dosages ranging from 25 to 200mg/kg), SIB1893 (from 25 to 100mg/kg), MPEP (from 25 to 100mg/kg) injected at 1 or 2h during PISE were ineffective in controlling status epilepticus (SE)." | 3.74 | Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus. ( Chen, PM; Lee, WL; Tang, FR; Tang, YC; Tsai, MC, 2007) |
| "Partial limbic seizures in rodents induced by pilocarpine progress from stages I-II (mouth and facial movements; head nodding) to stage III (forelimb clonus) and then progress rapidly to stages IV-V (generalized limbic seizures; rearing, and rearing with falling) followed by status epilepticus (SE)." | 3.74 | Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus. ( Feng, HJ; Kao, C; Macdonald, RL; Mathews, GC, 2008) |
| "We determined the efficacy of diazepam (DZP) and pentobarbital (PTB) in controlling prolonged status epilepticus (SE) in developing rats." | 3.74 | Effective treatments of prolonged status epilepticus in developing rats. ( Hasson, H; Kim, M; Moshé, SL, 2008) |
| " Single doses of 5-HT2 antagonists, mianserin (5mg/kg) and ritanserin (1mg/kg), effectively ameliorated withdrawal anxiety in the rat, returning behavioural function in the social interaction test and elevated plus maze to levels comparable to vehicle-treated animals." | 3.73 | Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists. ( Begg, DP; Hallam, KT; Norman, TR, 2005) |
| "This study analyzes the long-term effects of ovariectomy on the basal experimental anxiety of rats and the influence of this condition on the anxiolytic properties of diazepam and the 5-HT(1A) receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)." | 3.73 | Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents. ( Estrada-Camarena, E; Hernandez-Aragon, A; Picazo, O, 2006) |
| " To determine if immediate post-traumatic events such as seizures may activate Rho, we examined RhoA activation in the brains of rats with kainic acid-induced seizures." | 3.73 | Activation of Rho after traumatic brain injury and seizure in rats. ( Deschamps, K; Dubreuil, CI; Marklund, N; McIntosh, TK; McKerracher, L, 2006) |
| "Mice with point-mutated alpha2 GABAA receptor subunits (rendering them diazepam insensitive) are resistant to the anxiolytic-like effects of benzodiazepines (BZs) in unconditioned models of anxiety." | 3.73 | Both alpha2 and alpha3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm. ( Atack, JR; Dawson, GR; Morris, HV; Reynolds, DS; Stephens, DN, 2006) |
| "Lithium-pilocarpine induces status epilepticus (SE), leading to extensive damage and spontaneous recurrent seizures (SRS)." | 3.73 | The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy. ( Ferrandon, A; François, J; Koning, E; Nehlig, A, 2006) |
| "6 microg/microl) effectively prevented seizures induced by the unilateral GABAergic blockade of Area tempestas (bicuculline, 0." | 3.73 | Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae). ( Beleboni, Rde O; Coutinho-Netto, J; Cunha, AO; dos Santos, WF; Gelfuso, EA; Liberato, JL; Mortari, MR, 2006) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 3.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| "High doses of diazepam (10-20 mg/kg) were shown to reduce the volume of acute carrageenan-induced inflammatory paw edema in rats." | 3.72 | Reduction of inflammation in rats by diazepam: tolerance development. ( de Nucci, G; Lazzarini, R; Malucelli, BE; Muscará, MN; Palermo-Neto, J, 2003) |
| "This study evaluated the effectiveness of fosphenytoin as a single or adjunctive anticonvulsant treatment for nerve agent-induced status epilepticus." | 3.72 | Effects of fosphenytoin on nerve agent-induced status epilepticus. ( Benjamin, A; McDonough, JH; McMonagle, JD; Rowland, T; Shih, TM, 2004) |
| "In the present study we examined the effects of 1-aminoindan-1,5-dicarboxylic acid (AIDA), regarded as a selective and competitive mGluR1 antagonist, in animal models of anxiety." | 3.72 | The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist. ( Chojnacka-Wójcik, E; Kłodzińska, A; Stachowicz, K; Tatarczyńska, E, 2004) |
| "Previously, it was shown that subchronic application of the NMDA receptor antagonist ketamine (Ket) induces schizophrenia-related alterations, e." | 3.72 | Ketamine-induced changes in rat behaviour: a possible animal model of schizophrenia. Test of predictive validity. ( Becker, A; Grecksch, G, 2004) |
| "Status epilepticus is usually initially treated with a benzodiazepine such as diazepam." | 3.71 | Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus. ( Esmaeil, N; Jones, DM; Macdonald, RL; Maren, S, 2002) |
| "The 5-HT2B/2C receptor antagonist SB 206553 exerts anxiolytic effects in rat models of anxiety." | 3.71 | Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze. ( Berton, O; Chaouloff, F; Mormède, P; Takahashi, RN, 2001) |
| "The anxiolytic effects of aniracetam have not been proven in animals despite its clinical usefulness for post-stroke anxiety." | 3.71 | Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism. ( Kurasawa, M; Nakamura, K, 2001) |
| "Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone-derived neurosteroid allopregnanolone that potentiates gamma-aminobutyric acidA (GABA(A)) receptor-mediated inhibition." | 3.71 | Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2001) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 3.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| ") administration of (+/-) pentazocine (10, 30 & 50 mg/kg), a Sigma opioid agonist, resulted in a dose dependent anticonvulsant action against maximal electroshock seizures in mice." | 3.70 | Opioid receptor mediated anticonvulsant effect of pentazocine. ( Khanna, N; Khosla, R; Kohli, J, 1998) |
| "The present study extended the previous studies to determine the effects of acute and repeated administration of caffeine, a non-specific phosphodiesterase (PDE) inhibitor and pentoxyfylline, a specific type-4 phosphodiesterase (PDE4) inhibitor on (1) baseline anxiety-like behavior and (2) the response to an acute challenge with diazepam on anxiety-like behavior in the hole-board test." | 3.70 | Effects of acute and repeated dose administration of caffeine and pentoxifylline on diazepam-induced mouse behavior in the hole-board test. ( Campos, AR; Paula, WG; Rao, VS; Santos, FA; Silva, RM, 1999) |
| "To examine the putative seizure-protective properties of felbamate in an animal model of self-sustaining status epilepticus (SSSE)." | 3.70 | Felbamate in experimental model of status epilepticus. ( Baldwin, RA; Mazarati, AM; Sofia, RD; Wasterain, CG, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 3.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| "The effect of nimodipine alone and in combination with diazepam or phenytoin was tested in the electroshock-induced mouse model of status epilepticus." | 3.70 | Anticonvulsant effect of nimodipine alone and in combination with diazepam and phenytoin in a mouse model of status epilepticus. ( Khosla, P; Pandhi, P, 2000) |
| "The profile of action of ondansetron was assessed in a novel animal model of anxiety." | 3.69 | Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model. ( Kulkarni, SK; Roychoudhury, M, 1997) |
| "The repeated administration of nicotine at small doses, which do not produce whole body tremor or convulsion, causes tremor only in the tail (tail-tremor) of rats." | 3.69 | [Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model]. ( Gomita, Y; Kawasaki, H; Suemaru, K, 1997) |
| "The possibility that diazepam will influence spinal cord evoked potentials (SCEP), edema formation and cell changes following spinal cord injury (SCI) was examined in a rat model." | 3.69 | Benzodiazepine receptors influence spinal cord evoked potentials and edema following trauma to the rat spinal cord. ( Sharma, HS; Stålberg, E; Westman, J; Winkler, T, 1997) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 3.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| "Adult rats submitted to a protein deprivation schedule at perinatal age (from 14th day of fetal life until 50 days of age) and then recovered on balanced chow (D rats) were assayed in the elevated plus-maze test for anticonflict effects of diazepam and drugs with therapeutic efficacy in panic disorders as compared with controls (C rats)." | 3.68 | Perinatally protein-deprived rats and reactivity to anxiolytic drugs in the plus-maze test: an animal model for screening antipanic agents? ( Cordoba, NE; Laino, CH; Orsingher, OA, 1993) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 3.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "We describe a novel model of status epilepticus produced by the focal application of bicuculline methiodide into the deep prepiriform cortex of rats pretreated with lithium chloride." | 3.68 | A rodent model of focally evoked self-sustaining status epilepticus. ( Gale, K; Pazos, A; Peterson, CJ; Vinayak, S, 1992) |
| "Brain extracts from rats with hepatic encephalopathy due to thioacetamide-induced fulminant hepatic failure contained 4- to 6-fold higher concentrations of substances that inhibit radioligand binding to benzodiazepine receptors than corresponding control rat extracts." | 3.68 | Brain concentrations of benzodiazepines are elevated in an animal model of hepatic encephalopathy. ( Basile, AS; Fales, HM; Gammal, SH; Jaouni, T; Jones, EA; Pannell, L; Skolnick, P, 1990) |
| " The development of hepatic encephalopathy due to galactosamine-induced fulminant hepatic failure was consistently associated with a series of distinctive changes in the visual evoked potential waveform." | 3.67 | Visual evoked potentials in a rabbit model of hepatic encephalopathy. I. Sequential changes and comparisons with drug-induced comas. ( Brody, LE; Jacobs, R; Jones, EA; Pappas, SC; Schafer, DF, 1984) |
| "Thrombophlebitis is a common complication associated with infusion of intravenous sedatives, especially diazepam." | 3.67 | Development of an in vivo model for assessment of drug-induced vascular injury. ( Herrera, GQ; Jeske, AH; Johnson, JV; McDaniel, HK, 1989) |
| "In a proposed rat model for anxiety (electrical stimulation of the periaqueductal grey region), progabide (a GABA agonist) and diazepam both increased the latency to escape to a safe compartment and also the current needed to induce the escape response (escape threshold)." | 3.66 | Enhancing GABAergic transmission reverses the aversive state in rats induced by electrical stimulation of the periaqueductal grey region. ( Bovier, P; Broekkamp, CL; Lloyd, KG, 1982) |
| "Seven GABAmimetic drugs, namely cetyl gamma-aminobutyric acid (cetyl GABA), 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol, progabide, aminooxyacetic acid, alpha-acetylenic GABA, (-)-nipecotic acid ethyl ester and (+/-)-cis-4-hydroxynipecotic acid methyl ester, were tested for their potency to block "major" (generalized clonic-tonic) seizures in gerbils, induced by blowing at the animals with compressed air." | 3.66 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "Repeated seizures, whether induced by kindling or electroshock, caused a long-lasting (at least 24 hr) increase of [3H]diazepam binding in hippocampal membranes of Sprague-Dawley rats." | 3.66 | Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors. ( McNamara, JO; Patrone, V; Peper, AM, 1980) |
| "Harmine, a hallucinogen with potent monoamine oxidase inhibitory properties, induced abnormal behavior, including tremor, scratching, head twitch and cage biting, in the mouse." | 3.66 | Pharmacological characteristics of abnormal behavior induced by harmine with special reference to tremor in mice. ( Fujiwara, M; Hashimoto, Y; Kataoka, Y; Kawanishi, K; Ueki, S, 1981) |
| "Intra-amygdaloid unilateral application of low doses of kainic acid rapidly elicits, in both chronic and acute conditions, secondarily generalized convulsive seizures which often culminate in fatal true status epilepticus unless appropriate anti-epileptic drugs are provided." | 3.66 | [Epileptogenic action of intra-amygdaloid injection of kainic acid]. ( Ben-Ari, Y; Lagowska, J, 1978) |
| "Senegalese baboons (Papio papio), with a natural syndrome of photosensitive epilepsy, consistently show generalized myoclonic jerks if stimulated stroboscopically at hourly intervals, two to eight hours after the intravenous administration of allylglycine, 200 mg/kg." | 3.65 | A primate model for testing anticonvulsant drugs. ( Horton, RW; Meldrum, BS; Toseland, PA, 1975) |
| "Based on data from diverse seizure models, we hypothesized that cholinergic mechanisms are involved in the mechanisms underlying ASD resistance of SE." | 2.52 | Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models. ( Löscher, W, 2015) |
| " Novel data indicated that neither FSL nor FRL rats exhibited alterations in swim test immobility following chronic administration of the psychomotor stimulant amphetamine (2 mg/kg) and the anticholinergic scopolamine (2 mg/kg), which typically reduce immobility after acute administration." | 2.39 | Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression. ( Janowsky, DS; Overstreet, DH; Pucilowski, O; Rezvani, AH, 1995) |
| "5-Hydroxytryptophan has the opposite effect exacerbating the behavioural response to the aversive situation." | 2.38 | The pharmacology of the 5-HT4 receptor. ( Costall, B; Naylor, RJ, 1993) |
| "Acute colitis was induced with 5 days of dextran sodium sulfate (DSS, 3%) in the drinking water." | 1.72 | Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis. ( Gold, MS; Loeza-Alcocer, E, 2022) |
| "Only diazepam significantly increased seizure freedom." | 1.72 | Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs. ( Billingsley, P; Metcalf, CS; Pruess, T; Rueda, C; Saunders, GW; Smith, MD; Thomson, K; West, PJ; Wilcox, KS, 2022) |
| " Using an animal model of chemically-induced epileptic seizures, we tested exercise alone as non-pharmacological therapy, and exercise combined with an anti-inflammatory drug." | 1.72 | Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures. ( Barbosa, BB; Coitinho, AS; de Lima Rosa, G; Domingues, AM; Guzzo, EFM; Nunes, SEB; Padilha, RB; Siqueira, IR, 2022) |
| "The fact that inflammation triggers epileptic seizures brings to mind the antiepileptic properties of anti-inflammatory drugs." | 1.72 | The antiinflammatory and electrophysiological effects of fingolimod on penicillin-induced rats. ( Çelik, H; Çetinkaya, A; Torun, İE; Türel, CA; Türel, İ, 2022) |
| "camptopus in acute models of epileptic seizures in Wistar rats." | 1.62 | Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats. ( Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD, 2021) |
| "Amantadine treatment also reduces the production of NO and metabolism of GABA." | 1.56 | Amantadine exerts anxiolytic like effect in mice: Evidences for the involvement of nitrergic and GABAergic signaling pathways. ( Garg, C; Garg, M; Walia, V, 2020) |
| "Aged insomnia rat model was established with subcutaneous injection of D-galactose for 42 days and then intraperitoneal injection of para-chlorophenylalanine for 3 days." | 1.56 | Sedative and Hypnotic Effects and Transcriptome Analysis of Polygala tenuifolia in Aged Insomnia Rats. ( Peng, ZP; Ren, XJ; Wang, GY; Wang, QQ; Zhang, XP, 2020) |
| "Memantine pretreatment (18 mg/kg sc) produced in rats poisoned with soman significantly better protective ratios (PRs) than the two carbamates - 1." | 1.51 | Prophylactic potential of memantine against soman poisoning in rats. ( Bokonjić, D; Jokanović, M; Kilibarda, V; Škrbić, R; Stojiljković, MP; Vulović, M, 2019) |
| "Quercetin treatment was found to significantly reduce anxiety-like behaviors in mTBI-induced mice." | 1.51 | Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury. ( Ghorbanihaghjo, A; Kosari-Nasab, M; Mesgari-Abbasi, M; Salari, AA; Shokouhi, G, 2019) |
| "Diazepam-resistant SE was induced in adult mice fed with standard or ketogenic diet or in cannabinoid receptor type 1 (CB1) receptor knock-out mice." | 1.48 | Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. ( Butler, CR; Guilmette, E; Pauletti, A; Piro, JR; Porcu, L; Rizzi, M; Salamone, A; Samad, TA; Sheehan, MJ; Terrone, G; Vezzani, A; Villa, BR, 2018) |
| "Seizures affect about 50 million people around the world." | 1.48 | Clarified Açaí ( ( Arrifano, GPF; Carvalho, JCT; Crespo-López, ME; Farina, M; Lichtenstein, MP; Rogez, H; Souza-Monteiro, JR; Suñol, C, 2018) |
| "Cunaniol-induced seizures displayed a cyclic development of electrocorticographic seizures, presenting interictal-like spike and ictal period, which correlates to the behavioral observations and is in line with acute seizures induced by pentylenetetrazole." | 1.48 | Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses. ( Barbas, LAL; de Mello, VJ; do Nascimento, JLM; Dos Santos Batista, L; Dos Santos Batista, P; Farias, RAF; Gomes-Leal, W; Hamoy, M; Hutchison, WD; Marcondes, HC; Taylor, JG; Torres, MF, 2018) |
| " The dose-response curve for diazepam indicated that the 0." | 1.48 | Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats. ( Bernal-Morales, B; Contreras, CM; Cueto-Escobedo, J; Guillén-Ruiz, G; Rodríguez-Landa, JF, 2018) |
| "Riluzole is an antiglutamatergic agent and the only drug to offer some effect on the life expectancy of ALS patients." | 1.46 | Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of amyotrophic lateral sclerosis substantiated by riluzole and diazepam. ( Andreasen, SR; Christensen, TB; Holm, MM; Lundbye, CJ; Schmitt-John, T; Thielsen, KD, 2017) |
| "Diazepam, however, was more effective than escitalopram in suppressing MB." | 1.46 | Marble burying as compulsive behaviors in male and female mice. ( Chourbaji, S; Lerch, S; Taylor, GT, 2017) |
| "Diazepam (2mg/kg) was used as positive control." | 1.46 | Anxiolytic properties of N-acetylcysteine in mice. ( Benvenutti, R; Elisabetsky, E; Gama, CS; Giongo, F; Herrmann, AP; Noetzold, G; Piato, AL; Santos, P, 2017) |
| "Humanin (HN) is an endogenous 24-residue peptide." | 1.46 | Humanin ameliorates diazepam-induced memory deficit in mice. ( Maruyama, T; Murakami, M; Nagahama, M; Niikura, T, 2017) |
| "Febrile seizures are the most common type of convulsive events in children." | 1.43 | Forebrain-independent generation of hyperthermic convulsions in infant rats. ( Blumberg, MS; Kaila, K; Pospelov, AS; Puskarjov, M; Yukin, AY, 2016) |
| " Moreover, chronic administration of EA at dose 30 mg/kg ameliorated the memory deficit induced by diazepam (1 mg/kg, i." | 1.43 | Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments. ( Farbood, Y; Mansouri, MT; Mirshekar, MA; Naghizadeh, B; Sarkaki, A; Shabani, S, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "Diazepam treated animals showed significant alterations in the neurobehavior and neuro-histoarchitecture, which were improved after X-irradiation." | 1.43 | Low dose X-irradiation mitigates diazepam induced depression in rat brain. ( Dhawan, DK; Kaur, A; Singla, N, 2016) |
| "Hypothermia is proposed to be an index of nausea in rats." | 1.43 | Autonomic changes induced by provocative motion in rats bred for high (HAB) and low (LAB) anxiety-related behavior: Paradoxical responses in LAB animals. ( Andrews, PL; Carnevali, L; Nalivaiko, E; Neumann, ID; Sgoifo, A, 2016) |
| "Curcumin is a biologically active phytochemical presents in turmeric and has pharmacological actions that benefit patients with depression and anxiety." | 1.42 | The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. ( Li, J; Pan, J; Wang, R; Wu, S; Xie, X; Xu, Y; Yu, X; Yu, Y; Zheng, L, 2015) |
| "Diazepam was used as reference anticonvulsant drug." | 1.42 | Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed. ( FallahHuseini, H; Ghaznavi, H; Gholamine, B; Hosseinzadeh, A; Mehrzadi, S; Sadr, S; Shahbazi, A, 2015) |
| "Pilocarpine-induced SE was used to determine if COX-2 inhibition with NS-398, when administered alone or with diazepam, decreases the duration and/or intensity of SE and/or reduces neuronal injury in the rat hippocampus." | 1.42 | Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus. ( Dudek, FE; Ekstrand, JJ; Pouliot, WA; Trandafir, CC, 2015) |
| "In a first step, we examined anti-seizure effects of 6 AEDs on spontaneous recurrent focal electrographic seizures and secondarily generalized convulsive seizures in epileptic mice, showing that the focal nonconvulsive seizures were resistant to carbamazepine and phenytoin, whereas valproate and levetiracetam exerted moderate and phenobarbital and diazepam marked anti-seizure effects." | 1.42 | Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice. ( Bankstahl, M; Klein, S; Löscher, W, 2015) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 1.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| "Treatment-resistant seizures affect about a third of patients suffering from epilepsy." | 1.42 | Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish. ( Afrikanova, T; Buenafe, OE; Crawford, AD; De Prins, A; de Witte, PA; Esguerra, CV; Kaminski, RM; Langlois, M; Leclercq, K; Rospo, CC; Smolders, I; Van Eeckhaut, A, 2015) |
| "Tetramethylenedisulfotetramine (TETS) is a potent convulsant GABAA receptor blocker." | 1.42 | Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. ( Austin, AT; Bruun, DA; Cao, Z; Hammock, BD; Hulsizer, S; Inceoglu, B; Lein, PJ; Pessah, IN; Rogawski, MA; Tancredi, DJ; Vito, ST, 2015) |
| "In mice, influenza induced dynamic changes in immune cell GABAA subunit expression: α1 subunits decreased on alveolar macrophage, but increased on monocytes, CD4+ and CD8+ T cells." | 1.42 | Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection. ( Godlee, A; Goulding, J; Grover, V; Gurney, S; Hussell, T; Ma, D; Maze, M; Sanders, RD; Singh, S; Snelgrove, R, 2015) |
| "Pain is the most common reason a patient sees a physician." | 1.40 | Antinociceptive properties of physalins from Physalis angulata. ( Evangelista, AF; Lima, Mda S; Pereira Soares, MB; Ribeiro, IM; Santos, GG; Tomassini, TC; Villarreal, CF, 2014) |
| "Trials of novel compounds for the treatment of schizophrenia are typically tested in patients following brief withdrawal of ongoing medication despite known long-term changes in the dopamine (DA) system following chronic antipsychotic drug therapy." | 1.40 | Prior antipsychotic drug treatment prevents response to novel antipsychotic agent in the methylazoxymethanol acetate model of schizophrenia. ( Cook, JM; Gill, KM; Grace, AA; Poe, MM, 2014) |
| "Paraoxon (POX) is an active metabolite of organophosphate (OP) pesticide parathion that has been weaponized and used against civilian populations." | 1.40 | Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication. ( Blair, RE; Carter, DS; DeLorenzo, RJ; Deshpande, LS; Phillips, KF, 2014) |
| " Although monoamine oxidase activity remained unaltered by oleanolic acid, chronic administration of oleanolic acid augmented hippocampal BDNF level." | 1.40 | Plurality of anxiety and depression alteration mechanism by oleanolic acid. ( Costa, EA; Da Rocha, FF; Fajemiroye, JO; Florentino, IF; Galdino, PM; Ghedini, PC; Polepally, PR; Zjawiony, JK, 2014) |
| "Tetramethylenedisulfotetramine (TETS) is a potent convulsant poison for which there is currently no approved antidote." | 1.40 | Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication. ( Austin, AT; Banks, CN; Bruun, DA; Hammock, BD; Inceoglu, B; Lein, PJ; Rogawski, MA; Tancredi, DJ; Vito, ST; Zolkowska, D, 2014) |
| "Spontaneous epileptic seizures in this model are known to be resistant to major antiepileptic drugs." | 1.40 | Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures. ( Bankstahl, M; Gramer, M; Hausknecht, M; Klein, S; Löscher, W, 2014) |
| "Spontaneous seizures occurred in the 1, 2 and 4 h SE groups, and the seizure frequency increased with the prolongation of SE." | 1.39 | One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death. ( Chen, LL; Feng, HF; Mao, XX; Ye, Q; Zeng, LH, 2013) |
| " The doses of modulators were selected on the basis of dose-response studies." | 1.39 | Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam. ( Bhutada, P; Deshmukh, P; Dixit, P; Kaulaskar, S; Thakur, K, 2013) |
| "Diazepam-induced sleep was used for the evaluation of the sedative properties." | 1.39 | The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice. ( Moto, FC; Ngah, E; Ngo Bum, E; Ngoupaye, GT; Rakotonirina, A; Rakotonirina, SV; Taiwe, GS; Talla, E, 2013) |
| "CD-1 mice were dosed with Bacille Calmette-Guérin (BCG) and measures of body weight, locomotor activity, and immobility in the tail suspension test (TST) were made." | 1.39 | A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants. ( Clark, JA; Klee, N; Nizami, M; Platt, B; Schulenberg, J, 2013) |
| "Pretreatment with diazepam (DZP) significantly attenuated seizure severity." | 1.39 | Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization. ( Baggio, S; Battastini, AM; Calcagnotto, ME; Campos, MM; de Oliveira, DL; Dias, RD; Leite, CE; Moro, L; Mussulini, BH; Rico, EP; Rosemberg, DB; Souza, TM; Zenki, KC, 2013) |
| "Phenytoin has two important properties that are advantageous for assessing the validity of the theta suppression model: 1) it is a standard antiepileptic drug with no known anxiolytic effects, and 2) its primary mechanism of action is through suppression of the persistent sodium current, an effect that should also suppress hippocampal theta." | 1.38 | A critical test of the hippocampal theta model of anxiolytic drug action. ( Dickson, CT; Treit, D; Yeung, M, 2012) |
| "CFA-induced mechanical allodynia resulted in increased anxiety-like behaviors as evidenced by: (1) a significant decrease in percentage of time spent and number of entries in open arms of the elevated-plus maze (EPM), (2) a decrease in number of central squares visited in the open field (OF), and (3) a reduction in active social interactions in the social interaction test (SI)." | 1.38 | Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain. ( Beaudet, N; Beaudry, H; Bergeron, J; Bérubé, P; Drolet, G; Gendron, L; Parent, AJ; Sarret, P, 2012) |
| "Gabapentin was used to provide an anxiolytic effect on drug-free days." | 1.38 | Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats. ( Açikmeşe, B; Enginar, N; Hatipoğlu, I; Haznedar, S, 2012) |
| "Pretreatment with clonidine or yohimbine failed to affect basal plasma corticosterone and ACTH concentrations, but abolished diazepam-induced inhibition of the HPA axis activity." | 1.38 | The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats. ( Muck-Šeler, D; Pivac, N; Švob Štrac, D, 2012) |
| " We used male NMRI mice (28-32 g) and first established the dose-response relationship for pilocarpine (250-400 mg/kg; ip) to induce status epilepticus (SE)." | 1.38 | Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization. ( Kaminski, RM; Kumar, G; Mazzuferi, M; Rospo, C, 2012) |
| "Flumazenil treatment before BCAO reduced ischaemic neuronal damage exacerbated by benzodiazepine tolerance (P<0." | 1.38 | Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M, 2012) |
| "CSL also reversed successfully the memory deficits induced by scopolamine (0." | 1.37 | Reversal of memory deficits by Coriandrum sativum leaves in mice. ( Abdul Majeed, AB; Mani, V; Parle, M; Ramasamy, K, 2011) |
| "Diazepam (2mg/kg) was also tested at three times during the 24-h day in the elevated plus maze: at the beginning and end of the lights-on period (Zeitgeber times 23 and 11, respectively) and once in the dark just before the room lights came on (Zeitgeber time 20)." | 1.37 | The benzodiazepine diazepam demonstrates the usefulness of Syrian hamsters as a model for anxiety testing: evaluation of other classes of anxiolytics in comparison to diazepam. ( Batista, N; Delagrange, P; Gannon, RL; Hester, I; Huntley, C; Lungwitz, E; Millan, MJ; Peacock, A, 2011) |
| "Temporal lobe epilepsy is prevalent and can be difficult to treat effectively." | 1.37 | Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy. ( Buckmaster, PS; Lew, FH, 2011) |
| "Diazepam effects were blocked by flumazenil." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
| "Epilepsy affects 0." | 1.37 | Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. ( Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G, 2011) |
| "Imidazenil is an imidazo-benzodiazepine derivative with high intrinsic efficacy and selectivity for α2-, α3-, and α5- but low intrinsic efficacy for α1-containing GABA(A) receptors." | 1.37 | Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage. ( Auta, J; Davis, JM; Gocel, J; Guidotti, A; Kadriu, B; Larson, J; Nambiar, MP, 2011) |
| "pramipexole) known to produce compulsive behaviors in humans would increase marble burying." | 1.37 | Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety. ( Jimenez-Gomez, C; Osentoski, A; Woods, JH, 2011) |
| "Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear." | 1.37 | Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. ( Hu, XL; Liu, YY; Mei, L; Tan, GH; Xiong, ZQ; Yin, DM, 2011) |
| "The effects of GB-115 dipeptide, a retroanalog of endogenous CCK-4, on the behavioral indices in "elevated plus maze" (EPM) test and on the content of biogenic amines in the brain structures after discontinuation of a chronic administration of benzodiazepine (BZ) derivatives phenazepam (2." | 1.37 | [Effect of GB-115 dipeptide on anxiety in rats with model benzodiazepine withdrawal syndrome]. ( Gudasheva, TA; Kadnikov, IA; Kolik, LG; Seredenin, SB; Zhukov, VN, 2011) |
| "The presence of multiple seizures prior to medical treatment has been suggested as a potential predictor of poor outcome." | 1.36 | High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy. ( Brandt, C; Löscher, W, 2010) |
| "Diazepam and phenytoin were administered intraperitoneally at doses of 2 and 30 mg/kg, respectively, and brain and plasma concentrations were determined 60 min after administration using liquid chromatography-mass spectrometry." | 1.36 | Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy. ( Charman, SA; Davies, PJ; Nicolazzo, JA; Petrou, S; Steuten, JA; Taylor, N, 2010) |
| "The latency for development of convulsions and mortality rate was recorded in these models using mice." | 1.36 | Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice. ( Bansod, K; Bhutada, P; Dixit, P; Mundhada, D; Mundhada, Y; Umathe, S, 2010) |
| "Muscimol was effective in reducing AEP in both LA and HA rats." | 1.36 | GABAergic regulation of auditory sensory gating in low- and high-anxiety rats submitted to a fear conditioning procedure. ( Brandão, ML; Cabral, A; Nobre, MJ, 2010) |
| "Diazepam was used as a positive control." | 1.35 | Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice. ( Barron, S; Farook, JM; Krazem, A; Lewis, B; Littleton, JM; Morrell, DJ, 2008) |
| "To observe yin deficiency model mice anxiety action by means of the elevated plus-maze and light-dark transitions of mice." | 1.35 | [Effects of Semen Ziziphi Spinosae on the anxiety behavior of the yin deficiency mice]. ( Cui, Y; Dai, YX; Rong, CL, 2008) |
| "Diazepam significantly increase incidence of paradoxical sleep episodes with maximal duration till to 5 min." | 1.35 | Influence of diazepam on different behavioral states of sleep-waking cycle. ( Chkhartishvili, E; Dzadzamia, Sh; Mchedlidze, O; Nachkebia, N; Oniani, T, 2009) |
| "The anxiolytic activity and adverse benzodiazepine-like effects of a bovine alpha s1-casein tryptic hydrolysate (CH) were evaluated." | 1.35 | Anxiolytic-like effects and safety profile of a tryptic hydrolysate from bovine alpha s1-casein in rats. ( Desor, D; Lalonde, R; Messaoudi, M; Schroeder, H, 2009) |
| "Diazepam (DIZ) was used as anticonvulsant." | 1.35 | A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice. ( Mustafa, AA; Salih, MA, 2008) |
| " Data obtained showed an anxiolytic- and anxiogenic-like profile of the chronic intake of and withdrawal from diazepam regimen in the EPM test, 22-KHz USV and startle reflex." | 1.35 | Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats. ( Brandão, ML; Castilho, VM; De Ross, J; Nobre, MJ, 2008) |
| "The treatment with haloperidol worsened the adverse effects of chronic social stress having effects similar to stress on reward and motivation-related behaviours." | 1.35 | Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam. ( Abumaria, N; Flügge, G; Fuchs, E; Havemann-Reinecke, U; Hiemke, C; Rüther, E; Rygula, R; Zernig, G, 2008) |
| "A pharmacological model of migraine is described using ultrasound vocalization (USV) of rats following central inflammation-induced sensitization to tactile stimulation." | 1.35 | Tactile-induced ultrasonic vocalization in the rat: a novel assay to assess anti-migraine therapies in vivo. ( Martino, G; Perkins, MN, 2008) |
| "In addition, convulsions induced by lithium-methomyl treatment were associated with widespread neurodegeneration of limbic structures." | 1.34 | Lithium-methomyl induced seizures in rats: a new model of status epilepticus? ( Blaszczak, P; Calderazzo, L; Cavalheiro, EA; Dekundy, A; Kaminski, RM; Parada-Turska, J; Turski, WA, 2007) |
| "The current first line treatment of status epilepticus (SE) is based on the use of compounds that enhance GABAergic transmission or block sodium channels." | 1.34 | Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat. ( Mathiesen, C; Møller, A; Nissinen, J; Pitkänen, A; Rønn, LC, 2007) |
| "The aim of this study was to assess the efficacy of a structurally novel, potent, selective mGlu2/3 receptor agonist with improved bioavailability (LY404039) in animal models predictive of antipsychotic and anxiolytic efficacy." | 1.34 | In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders. ( Griffey, KI; Johnson, BG; Knitowski, KM; McKinzie, DL; Monn, JA; Perry, KW; Rorick-Kehn, LM; Salhoff, CR; Schoepp, DD; Tizzano, JP; Witkin, JM, 2007) |
| "Levetiracetam (LEV) is a structurally novel antiepileptic drug (AED) which has demonstrated a broad spectrum of anticonvulsant activities both in experimental and clinical studies." | 1.34 | Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats. ( Bethmann, K; Brandt, C; Fedrowitz, M; Gastens, AM; Glien, M; Löscher, W; Potschka, H; Volk, HA, 2007) |
| "A series of high-affinity GABA(A) agonists with good oral bioavailability in rat and dog and functional selectivity for the GABA(A)alpha2 and -alpha3 subtypes is reported." | 1.33 | Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders. ( Atack, JR; Blackaby, WP; Brown, N; Castro, JL; Cook, SM; Crawforth, JM; Ferris, P; Goodacre, SC; Hallett, DJ; Kelly, S; Lewis, RT; Marshall, G; Owens, AP; Pike, A; Smith, AJ; Sohal, B; Stanley, J; Street, LJ; Wafford, KA, 2006) |
| "Chronic focal epilepsy was induced by injecting 25-50 ng of tetanus toxin or vehicle alone (controls) into the motor neocortex of rats." | 1.33 | Characterization of the tetanus toxin model of refractory focal neocortical epilepsy in the rat. ( Cock, HR; Nilsen, KE; Walker, MC, 2005) |
| "If epilepsy developed, the seizures were less frequent in DZP-treated animals compared to the vehicle group (median 16." | 1.33 | Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat. ( Kharatishvili, I; Lukasiuk, K; Narkilahti, S; Nissinen, J; Pitkänen, A, 2005) |
| "Diazepam was used as a reference compound." | 1.33 | The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action. ( Chojnacka-Wójcik, E; Kłodzińska, A; Tatarczyńska, E, 2005) |
| "Rodent seizure models have significantly contributed to our basic understanding of epilepsy." | 1.33 | Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. ( Baier, H; Baraban, SC; Castro, PA; Taylor, MR, 2005) |
| "Increased seizure duration [3,522 +/- 660 sec (SEM) vs." | 1.33 | Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity. ( Allan, SM; Davies, RE; Heenan, LE; Patel, HC; Ross, FM; Rothwell, NJ, 2006) |
| "Rats treated with isoflurane had the best cognitive recovery (p < 0." | 1.33 | Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. ( Alexander, H; Clark, RS; Dixon, CE; Jenkins, L; Kochanek, PM; Statler, KD; Vagni, V, 2006) |
| "Onset, duration of clonic convulsions and percentage mortality/recovery were recorded." | 1.33 | Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action. ( Dhir, A; Kulkarni, SK; Naidu, PS, 2006) |
| "Pre-treatment with diazepam, 10 and 20mg/kg, and chlormethiazole, 50 and 100mg/kg, attenuated the development of hyperthermia." | 1.32 | Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome. ( Kato, S; Nisijima, K; Shioda, K; Takano, K; Yoshino, T, 2003) |
| "Numbers of ictal events (seizure) and latency to the first event were reduced by prophylactic DZP." | 1.32 | Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model. ( Anschel, DJ; Fisher, RS; Ortega, E, 2004) |
| "Treatment with imipramine (3 x 30 mg/kg i." | 1.32 | Does rat global transient cerebral ischemia serve as an appropriate model to study emotional disturbances? ( Allain, H; Amiot, N; Bantsiele, GB; Bentué-Ferrer, D; Bourin, M; Reymann, JM, 2004) |
| "Using an amygdala-kindled seizure paradigm, we evaluated the acute and chronic anticonvulsant effects of lamotrigine (LTG)." | 1.31 | Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam. ( Heynen, T; Krupp, E; Li, XL; Post, RM; Weiss, SR, 2000) |
| "Pretreatment with diazepam (0." | 1.31 | Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. ( Cazala, P; David, V; Gold, LH; Koob, GF, 2001) |
| "The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was inhibited by pretreatment with MK-801 ((+)-5-methyl-10,11-dihydro-5H-dibenzo(a,d)cycloheptan-5,10-imine maleate), 7-chlorokynurenic acid and ifenprodil." | 1.30 | Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. ( Misawa, M; Suzuki, T; Tsuda, M, 1997) |
| "Like devazepide, IQM-95,333 was a more potent antagonist of CCK-8S- than of CCK-4-induced contraction of the longitudinal muscle from guinea-pig ileum, suggesting selective antagonism at CCKA receptors." | 1.30 | Pharmacological evaluation of IQM-95,333, a highly selective CCKA receptor antagonist with anxiolytic-like activity in animal models. ( Ballaz, S; Barber, A; Del Río, J; Fortuño, A; García-López, MT; Gómez-Monterrey, I; González-Muñiz, R; Herranz, R; Martin-Martínez, M, 1997) |
| "Pretreatment with diazepam completely prevents both penicillin-induced hypothermia and SWDs." | 1.30 | The connection between absence-like seizures and hypothermia induced by penicillin: possible implication on other animal models of petit mal epilepsy. ( Car, M; Ostojić, ZS; Rakić, L; Ruzdijić, S; Veskov, R, 1997) |
| "Myoclonic, clonic and tonic seizures were induced by i." | 1.29 | Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil. ( Hönack, D; Löscher, W; Rundfeldt, C; Wlaź, P, 1995) |
| "After baseline recordings, seizures were induced with a pentylenetetrazol (PTZ) bolus and a 20 min infusion (5-6 mg/kg/min)." | 1.29 | Respiratory drive during status epilepticus and its treatment: comparison of diazepam and lorazepam. ( Fordyce, WE; Terndrup, TE, 1995) |
| "Pretreatment with diazepam (1." | 1.29 | Observations of novel behaviors as indices of ethanol withdrawal-induced anxiety. ( Knapp, DJ; Pohorecky, LA; Saiers, JA, 1993) |
| " Chronic administration of the selective serotonin re-uptake inhibitors fluoxetine and clomipramine (CMI) at 5 mg/kg per day and fluvoxamine at 10 mg/kg twice a day significantly decreased schedule-induced polydipsia (SIP) on day 15 and throughout the remainder of the study compared to control rats." | 1.29 | Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder. ( Corbett, R; Cornfeldt, M; Dunn, RW; Smith, C; Szewczak, M; Woods, A, 1993) |
| "Abecarnil is a beta-carboline agonist at benzodiazepine receptors with potent anxiolytic activity but no muscle relaxant side effects in rodents." | 1.29 | Effect of the beta-carboline abecarnil on spinal reflexes in mice and on muscle tone in genetically spastic rats: a comparison with diazepam. ( Stephens, DN; Turski, L, 1993) |
| "(-)-Baclofen was the only one of the three compounds tested that reversed in a dose-dependent manner the effects of tone exposure on both the amplitude of the click-evoked potentials recorded from the IC and on measures of the changes in temporal integration based on these potentials." | 1.29 | Effects of (-)-baclofen, clonazepam, and diazepam on tone exposure-induced hyperexcitability of the inferior colliculus in the rat: possible therapeutic implications for pharmacological management of tinnitus and hyperacusis. ( Møller, AR; Szczepaniak, WS, 1996) |
| " Animals pretreated with this hepatotoxic agent showed a significant prolongation in the half-life of diazepam in plasma that is due more to an increase in volume of distribution rather than to a decrease in clearance." | 1.28 | Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury. ( Díaz-García, JM; Fos-Galve, D; Oliver-Botana, J, 1992) |
| "Evidence suggests that soman-induced convulsions may be associated with postexposure brain neuropathology." | 1.28 | Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. ( Capacio, BR; Koviak, TA; Shih, TM, 1991) |
| " In addition, the rewarding efficacy of the cocaine dosing parameters was subsequently confirmed in the runway subjects by conditioned place preference." | 1.28 | Animal model for investigating the anxiogenic effects of self-administered cocaine. ( Ettenberg, A; Geist, TD, 1991) |
| "Caffeine treatment at the dose 10 mg/kg b." | 1.28 | Validation of aversion towards open space and height as a measure of anxiety in the genetically based animal model of depression. ( Golda, V; Petr, R, 1990) |
| "Diazepam treatment alleviates in the first session aversion towards open space and hight in the elevated plus-maze only in the genetically hypertensive rats of both sexes and in the normotensive males." | 1.28 | Animal model of anxiety: effect of acute diazepam treatment in the older adult genetically hypertensive rats of Koletsky type and in the older adult rats of Wistar strain. ( Golda, V; Petr, R, 1989) |
| "Diazepam treatment significantly reduced the frequency of dystonic movements in the mutant." | 1.27 | Alterations in cerebellar glutamic acid decarboxylase (GAD) activity in a genetic model of torsion dystonia (rat). ( Beales, M; Gordon, JH; Lorden, JF; Oltmans, GA, 1984) |
| " Improvement occurred after a single dose of the anxiolytic drugs but did not occur until 10-18 days after daily dosing with standard tricylic antidepressants and the MAO inhibitor isocarboxazid." | 1.27 | Effects of selected drugs on spontaneously occurring abnormal behavior in beagles. ( Barnett, A; Brody, PE; Eisenstein, N; Iorio, LC, 1983) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 1.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| " +/- Pindolol, an antagonist at 5-HT1 receptors, showed a biphasic dose-response curve with a fall in entry ratio at one high dose." | 1.27 | Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors. ( Critchley, MA; Handley, SL, 1987) |
| " These data suggest that antidepressants acquire anxiolytic properties following chronic administration and that this effect appears to be independent of the benzodiazepine receptor system." | 1.27 | The effects of chronic antidepressant treatment in an animal model of anxiety. ( Aitken, DH; Bodnoff, SR; Meaney, MJ; Quirion, R; Suranyi-Cadotte, B, 1988) |
| " In a separate experiment, Ro 15-1788 produced a PTZ-like stimulus when given at 2-day intervals during chronic administration of DZP." | 1.27 | Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol. ( Emmett-Oglesby, MW; Harris, CM; Idemudia, SO; Lal, H; Mathis, DA, 1988) |
| "Carbamazepine and phenytoin were ineffective or aggravated the seizures." | 1.27 | Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat. ( Depaulis, A; Marescaux, C; Micheletti, G; Reis, J; Rumbach, L; Vergnes, M; Warter, JM, 1985) |
| "The "spontaneous" myoclonus which followed vermisectomy (MV) was "massive", but involved firstly the trunk and secondarily the face and limbs; no ECoG paraoxysm accompanied this myoclonus, but we observed a parietal evoked potential of small amplitude, 10--15 msec after its onset." | 1.26 | Myoclonus developing after vermisectomy in photosensitive Papio papio. ( Brailowsky, S; Menini, C; Naquet, R, 1978) |
| "Phenytoin and diazepam were maximally effective at concentrations of 20 microgram/ml and 3-4 microgram/ml, respectively, in good agreement with their effective concentrations in clinical practice." | 1.26 | The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs. ( Hoffer, BJ; Oliver, AP; Wyatt, RJ, 1977) |
| "Of particular importance are the arrhythmias observed immediately after experimentally induced acute myocardial infarction (AMI)." | 1.25 | Pharmacological modification of arrhythmias after experimentally induced acute myocardial infarction. Drugs acting on the nervous system. ( Kniffen, FJ; Lucchesi, BR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 63 (12.91) | 18.7374 |
| 1990's | 61 (12.50) | 18.2507 |
| 2000's | 131 (26.84) | 29.6817 |
| 2010's | 204 (41.80) | 24.3611 |
| 2020's | 29 (5.94) | 2.80 |
| Authors | Studies |
|---|---|
| Goodacre, SC | 1 |
| Street, LJ | 1 |
| Hallett, DJ | 1 |
| Crawforth, JM | 1 |
| Kelly, S | 1 |
| Owens, AP | 1 |
| Blackaby, WP | 1 |
| Lewis, RT | 1 |
| Stanley, J | 1 |
| Smith, AJ | 1 |
| Ferris, P | 1 |
| Sohal, B | 1 |
| Cook, SM | 1 |
| Pike, A | 1 |
| Brown, N | 1 |
| Wafford, KA | 1 |
| Marshall, G | 1 |
| Castro, JL | 1 |
| Atack, JR | 2 |
| Herrera-Ruiz, M | 1 |
| González-Cortazar, M | 1 |
| Jiménez-Ferrer, E | 1 |
| Zamilpa, A | 1 |
| Alvarez, L | 1 |
| Ramírez, G | 1 |
| Tortoriello, J | 1 |
| Liu, H | 2 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Avdeef, A | 1 |
| Tam, KY | 1 |
| Lima, Mda S | 1 |
| Evangelista, AF | 1 |
| Santos, GG | 1 |
| Ribeiro, IM | 1 |
| Tomassini, TC | 1 |
| Pereira Soares, MB | 1 |
| Villarreal, CF | 1 |
| Nikalje, APG | 1 |
| Shaikh, AN | 1 |
| Shaikh, SI | 1 |
| Kalam Khan, FA | 1 |
| Sangshetti, JN | 1 |
| Shinde, DB | 1 |
| Zagórska, A | 1 |
| Kołaczkowski, M | 1 |
| Bucki, A | 1 |
| Siwek, A | 1 |
| Kazek, G | 1 |
| Satała, G | 1 |
| Bojarski, AJ | 1 |
| Partyka, A | 1 |
| Wesołowska, A | 3 |
| Pawłowski, M | 1 |
| Eltahawy, NA | 1 |
| Ibrahim, AK | 1 |
| Radwan, MM | 1 |
| Zaitone, SA | 1 |
| Gomaa, M | 1 |
| ElSohly, MA | 1 |
| Hassanean, HA | 1 |
| Ahmed, SA | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Said, ES | 1 |
| Elsayed, AM | 1 |
| Rashed, LA | 1 |
| Nadwa, EH | 1 |
| Alsuhaibani, NA | 1 |
| Alfuraih, BS | 1 |
| Mahmoud, RH | 1 |
| Loeza-Alcocer, E | 1 |
| Gold, MS | 1 |
| Zhou, R | 1 |
| Wang, Y | 3 |
| Cao, X | 1 |
| Li, Z | 1 |
| Yu, J | 2 |
| West, PJ | 1 |
| Thomson, K | 1 |
| Billingsley, P | 1 |
| Pruess, T | 1 |
| Rueda, C | 1 |
| Saunders, GW | 1 |
| Smith, MD | 1 |
| Metcalf, CS | 1 |
| Wilcox, KS | 1 |
| Gurrell, R | 1 |
| Iredale, P | 1 |
| Evrard, A | 1 |
| Duveau, V | 1 |
| Ruggiero, C | 1 |
| Roucard, C | 1 |
| Fontana, BD | 1 |
| Parker, MO | 2 |
| de Lima Rosa, G | 1 |
| Guzzo, EFM | 1 |
| Nunes, SEB | 1 |
| Padilha, RB | 1 |
| Domingues, AM | 1 |
| Barbosa, BB | 1 |
| Siqueira, IR | 1 |
| Coitinho, AS | 2 |
| Boudjafad, Z | 1 |
| Lguensat, A | 1 |
| Elmardadi, K | 1 |
| Dahi, A | 1 |
| Bennis, M | 1 |
| Ba-M'hamed, S | 1 |
| Garcia, R | 1 |
| Danis, A | 1 |
| Baranoglu Kilinc, Y | 1 |
| Torun, IE | 2 |
| Hanci, F | 1 |
| Kilinc, E | 1 |
| Ankarali, H | 1 |
| Türel, CA | 1 |
| Çelik, H | 1 |
| Çetinkaya, A | 1 |
| Türel, İ | 1 |
| de Labra, C | 1 |
| Cudeiro, J | 1 |
| Rivadulla, C | 1 |
| Tsutsumi, H | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy and Safety Study of a IMSS Developed Phytopharmaceutical for the Treatment of Anxiety. Double Blind and Randomized Clinical Trial Controlled With Alprazolam[NCT03702803] | Phase 2 | 122 participants (Anticipated) | Interventional | 2016-03-16 | Recruiting | ||
| A 57-Week, Multicenter, Active-treatment, Open-label Extension Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures[NCT04686786] | Phase 2 | 120 participants (Anticipated) | Interventional | 2020-12-08 | Enrolling by invitation | ||
| A Randomized, Double-blind, Placebo-controlled, Parallel Group, Multicenter Trial of CVL-865 as Adjunctive Therapy in Adults With Drug-Resistant Focal Onset Seizures (REALIZE Trial)[NCT04244175] | Phase 2 | 150 participants (Anticipated) | Interventional | 2020-01-27 | Recruiting | ||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| The Efficacy of Strategic Memory Training Coupled With Non-invasive Brain Stimulation Techniques in Healthy Aging Population and Subjective Cognitive Decline Patients: a Randomized-controlled Study[NCT05929872] | 56 participants (Anticipated) | Interventional | 2023-07-30 | Not yet recruiting | |||
| Thermoregulation Among Individuals With First-episode Psychosis[NCT04369677] | 20 participants (Anticipated) | Observational | 2023-11-01 | Not yet recruiting | |||
| Mood Disorder Cohort Research Consortium (MDCRC) in Korea[NCT03088657] | 500 participants (Anticipated) | Observational [Patient Registry] | 2015-09-30 | Recruiting | |||
| Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery[NCT01505465] | 50 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| A Randomized, Double-blind, Placebo- and Active Comparator-controlled, Crossover Trial to Examine the Effect of Multiple Doses of CVL-865 on Panic Symptoms Induced by Carbon Dioxide Inhalation in Healthy Subject[NCT04592536] | Phase 1 | 56 participants (Actual) | Interventional | 2020-10-06 | Completed | ||
| Efficacy of Combined Ketamine and Midazolam for Treatment of Generalized Convulsive Status Epilepticus in Children .[NCT05779657] | Phase 2/Phase 3 | 144 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| Trial of Intracerebral Infusion in Patients With Medically Intractable Epilepsy[NCT00005925] | Phase 1 | 3 participants (Actual) | Interventional | 2000-06-23 | Terminated | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Sleep time change from 96 hours before surgery to 72 hours after surgery (NCT01505465)
Timeframe: 96 hours before surgery to 72 hours after surgery
| Intervention | minutes (Mean) |
|---|---|
| Study: Melatonin | 20 |
| Control: Placebo | -55 |
14 reviews available for diazepam and Disease Models, Animal
| Article | Year |
|---|---|
Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug T | 2015 |
Predatory stress as an experimental strategy to measure fear and anxiety-related behaviors in non-human primates.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Behavior, Animal; Diazepam; Disease Models, Animal; | 2008 |
Why is the developing brain more susceptible to status epilepticus?
Topics: Animals; Animals, Newborn; Brain; Diazepam; Disease Models, Animal; Female; Humans; Male; Pentobarbi | 2009 |
[Treatment of status epilepticus].
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electric Stimulation Therapy; Humans; Ma | 2001 |
Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1).
Topics: Affect; Animals; Anxiety Disorders; Aprepitant; Autoreceptors; Behavior, Animal; Corticosterone; Dia | 2002 |
The role of diazepam in the treatment of nerve agent poisoning in a civilian population.
Topics: Adult; Animals; Antidotes; Chemical Warfare Agents; Civil Defense; Diazepam; Disease Models, Animal; | 2004 |
Benzodiazepine dependence.
Topics: Animals; Benzodiazepines; Chlordiazepoxide; Diazepam; Disease Models, Animal; Dose-Response Relation | 1981 |
The pharmacology of the 5-HT4 receptor.
Topics: 4-Aminobenzoic Acid; 5-Hydroxytryptophan; Animals; Anxiety; Arousal; Brain; Diazepam; Disease Models | 1993 |
Administration of antidepressants, diazepam and psychomotor stimulants further confirms the utility of Flinders Sensitive Line rats as an animal model of depression.
Topics: Animals; Antidepressive Agents; Depression; Diazepam; Disease Models, Animal; Motor Activity; Rats | 1995 |
Acute cellular alterations in the hippocampus after status epilepticus.
Topics: Animals; Barbiturates; Benzodiazepines; Cerebellar Nuclei; Diazepam; Disease Models, Animal; Drug To | 1999 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
The benzodiazepines: anxiolytic and withdrawal effects.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Disease Models, Animal; Ethanol; Flumaz | 1991 |
Hyperalgesia induced by emotional stress in the rat: an experimental animal model of human anxiogenic hyperalgesia.
Topics: Analgesia; Animals; Anxiety; Diazepam; Disease Models, Animal; Emotions; Humans; Hypophysectomy; Pai | 1986 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
474 other studies available for diazepam and Disease Models, Animal
| Article | Year |
|---|---|
Imidazo[1,2-a]pyrimidines as functionally selective and orally bioavailable GABA(A)alpha2/alpha3 binding site agonists for the treatment of anxiety disorders.
Topics: Administration, Oral; Animals; Anxiety Disorders; Binding Sites; Biological Availability; Cell Line; | 2006 |
Anxiolytic effect of natural galphimines from Galphimia glauca and their chemical derivatives.
Topics: Animals; Anti-Anxiety Agents; Disease Models, Animal; Galphimia; Mexico; Mice; Molecular Structure; | 2006 |
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological | 2010 |
Antinociceptive properties of physalins from Physalis angulata.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Freund's Adjuvant; Hyp | 2014 |
Microwave assisted synthesis and docking study of N-(2-oxo-2-(4-oxo-2-substituted thiazolidin-3ylamino)ethyl)benzamide derivatives as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Benzamides; Binding Sites; Disease Models, Animal; Half-Life; Liver; Mice; | 2014 |
Structure-activity relationships and molecular studies of novel arylpiperazinylalkyl purine-2,4-diones and purine-2,4,8-triones with antidepressant and anxiolytic-like activity.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Binding Sites; Disease Models, Animal; Models, | 2015 |
Mechanism of action of antiepileptic ceramide from Red Sea soft coral Sarcophyton auritum.
Topics: Allosteric Regulation; Animals; Anthozoa; Anticonvulsants; Binding Sites; Ceramides; Disease Models, | 2015 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations.
Topics: AMP-Activated Protein Kinases; Animals; Behavior, Animal; Caspase 3; Cell Death; Cognitive Dysfuncti | 2021 |
Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis.
Topics: Animals; Bicuculline; Colitis; Colon; Dextran Sulfate; Diazepam; Disease Models, Animal; Inflammator | 2022 |
Diazepam Monotherapy or Diazepam-Ketamine Dual Therapy at Different Time Points Terminates Seizures and Reduces Mortality in a Status Epilepticus Animal Model.
Topics: Analgesics; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Administration Schedule | 2021 |
Spontaneous recurrent seizures in an intra-amygdala kainate microinjection model of temporal lobe epilepsy are differentially sensitive to antiseizure drugs.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Diazepam; Disease Models, Animal; | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
Pronounced antiseizure activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Electroencephal | 2022 |
The larval diving response (LDR): Validation of an automated, high-throughput, ecologically relevant measure of anxiety-related behavior in larval zebrafish (Danio rerio).
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal; | 2022 |
Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diazepam; Disease Models, Animal; Epilepsy; Exercise; | 2022 |
The socially enriched environment test: a new approach to evaluate social behavior in a mouse model of social anxiety disorder.
Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Extinction, Psychological; Fear; Male; Mice; Pho | 2022 |
Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Cytokines; Diazepam; Disease Models, Animal; Epilep | 2023 |
The antiinflammatory and electrophysiological effects of fingolimod on penicillin-induced rats.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Contraindications, Drug; Diazepam; Disease Model | 2022 |
Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model.
Topics: Animals; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Magnetic Fields; Piloca | 2023 |
Cerebrospinal fluid neurotransmitter levels and central nervous system depression in a rat drug overdose model.
Topics: Administration, Oral; Animals; Biomarkers; Carboxymethylcellulose Sodium; Chromatography, Liquid; Di | 2020 |
Amantadine exerts anxiolytic like effect in mice: Evidences for the involvement of nitrergic and GABAergic signaling pathways.
Topics: Amantadine; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Diazepam; Disease Models | 2020 |
Anticonvulsant Activity of Essential Oil From Leaves of Zhumeria majdae (Rech.) in Mice: The Role of GABA
Topics: Animals; Anticonvulsants; Arginine; Diazepam; Disease Models, Animal; Dose-Response Relationship, Dr | 2020 |
New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome.
Topics: Animals; Anticonvulsants; Brain; Cell Proliferation; CRISPR-Cas Systems; Diazepam; Disease Models, A | 2020 |
Sedative and Hypnotic Effects and Transcriptome Analysis of Polygala tenuifolia in Aged Insomnia Rats.
Topics: Animals; China; Diazepam; Disease Models, Animal; Gene Expression Profiling; Hypnotics and Sedatives | 2020 |
Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Acetylcholinesterase; Animals; Brain Injuries; Diazepam; Disease Models, Animal; Electroencephalogra | 2020 |
Stress-mediated hyperactivity and anhedonia resistant to diazepam and fluoxetine in
Topics: Anhedonia; Animals; Diazepam; Disease Models, Animal; Drosophila; Fluoxetine; Stress, Psychological | 2021 |
Inverse Agonism of Cannabinoid Receptor Type 2 Confers Anti-inflammatory and Neuroprotective Effects Following Status Epileptics.
Topics: Animals; Anti-Inflammatory Agents; Benzophenones; Cytokines; Diazepam; Disease Models, Animal; Drug | 2020 |
Sevoflurane versus ketamine+diazepam anesthesia for assessing systemic and hepatic hemodynamics in rats with non-cirrhotic portal hypertension.
Topics: Anesthesia, Inhalation; Anesthesiology; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; | 2020 |
Beneficial effects of benzodiazepine on masticatory muscle dysfunction induced by chronic stress and occlusal instability in an experimental animal study.
Topics: Animals; Benzodiazepines; Case-Control Studies; Diazepam; Disease Models, Animal; Male; Masticatory | 2020 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; | 2020 |
Perillyl alcohol decreases the frequency and severity of convulsive-like behavior in the adult zebrafish model of acute seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relation | 2021 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mi | 2021 |
Atypical electrophysiological and behavioral responses to diazepam in a leading mouse model of Down syndrome.
Topics: Animals; Diazepam; Disease Models, Animal; Down Syndrome; Electrophysiological Phenomena; Female; Lo | 2021 |
Anxiolytic effect of chronic intake of supplemental magnesium chloride in rat.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Magnesium | 2021 |
Diazepam Impairs Innate and Adaptive Immune Responses and Ameliorates Experimental Autoimmune Encephalomyelitis.
Topics: Adaptive Immunity; Animals; Anti-Inflammatory Agents; Biomarkers; Diazepam; Disease Models, Animal; | 2021 |
Pharmacological evaluation of the anxiolytic-like effects of Lippia graveolens and bioactive compounds.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Resp | 2017 |
Interleukin-1β Plays a Pivotal Role via the PI3K/Akt/mTOR Signaling Pathway in the Chronicity of Mesial Temporal Lobe Epilepsy.
Topics: Animals; Anticonvulsants; Cells, Cultured; Child; Diazepam; Disease Models, Animal; Enzyme Inhibitor | 2016 |
Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice.
Topics: 5-alpha Reductase Inhibitors; Animals; Anxiety Disorders; Diazepam; Disease Models, Animal; Dose-Res | 2017 |
Anticonvulsant effects of antiaris toxicaria aqueous extract: investigation using animal models of temporal lobe epilepsy.
Topics: Animals; Antiaris; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Administra | 2017 |
Complex modulation by stress of the effect of seizures on long term potentiation in mouse hippocampal slices.
Topics: Animals; Anticonvulsants; Atropine; Corticosterone; Diazepam; Disease Models, Animal; Electric Stimu | 2017 |
Early deprivation increases high-leaning behavior, a novel anxiety-like behavior, in the open field test in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Animal; Exploratory Behavior; Femal | 2017 |
Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 2017 |
Maerua angolensis stem bark extract reverses anxiety and related behaviours in zebrafish-Involvement of GABAergic and 5-HT systems.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Capparaceae; Desipramine; Diazepam; Disease | 2017 |
Potential Involvement of Impaired BK
Topics: Animals; Anti-Anxiety Agents; Diazepam; Disease Models, Animal; Environment; Fragile X Mental Retard | 2018 |
Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer's disease: analysis of Osaka mutation-knockin mice.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Diazepam; Disease Models, Animal; | 2017 |
Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilep | 2019 |
Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of amyotrophic lateral sclerosis substantiated by riluzole and diazepam.
Topics: Amyotrophic Lateral Sclerosis; Animals; Diazepam; Disease Models, Animal; Hippocampus; Mice, Inbred | 2017 |
Progressive modulation of accumbal neurotransmission and anxiety-like behavior following protracted nicotine withdrawal.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Corpus Striatum; Dendritic Spines; Diazepam; Disease Models, | 2018 |
Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis.
Topics: Animals; Carrier Proteins; CD11b Antigen; Central Nervous System; Cytokines; Diazepam; Disease Model | 2017 |
DNA damage and oxidative stress induced by seizures are decreased by anticonvulsant and neuroprotective effects of lobeline, a candidate to treat alcoholism.
Topics: Alcoholism; Animals; Anticonvulsants; Antioxidants; Diazepam; Disease Models, Animal; DNA Damage; Hi | 2018 |
Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.
Topics: Animals; Brain; Brain Waves; Carbamates; Cognition Disorders; Diazepam; Disease Models, Animal; Dose | 2018 |
Anxiolytic- and antidepressant-like effects of Silymarin compared to diazepam and fluoxetine in a mouse model of mild traumatic brain injury.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Brain Injuries, Traumatic; Diazepam; Disease Mo | 2018 |
Marble burying as compulsive behaviors in male and female mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Citalopram; Compulsive Behavio | 2017 |
Hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam.
Topics: Animals; Antidepressive Agents; Astrocytes; Atrophy; Corticosterone; Depressive Disorder; Diazepam; | 2018 |
Comparing the Antiseizure and Neuroprotective Efficacy of LY293558, Diazepam, Caramiphen, and LY293558-Caramiphen Combination against Soman in a Rat Model Relevant to the Pediatric Population.
Topics: Animals; Anticonvulsants; Anxiety; Basolateral Nuclear Complex; Behavior, Animal; Child; Cyclopentan | 2018 |
Anxiolytic effects of ascorbic acid and ketamine in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Ascorbic Acid; Behavior, Animal; Diazepam; Disease Models, An | 2018 |
Minocycline in Alcohol Withdrawal Induced Anxiety and Alcohol Relapse in Rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Anti-Bacterial Agents; Anxiety; Diazepam; Disease Models, Ani | 2018 |
Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice.
Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Depression; Diazepam; Disease Models, | 2018 |
An on demand macaque model of mesial temporal lobe seizures induced by unilateral intra hippocampal injection of penicillin.
Topics: Animals; Anti-Bacterial Agents; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rel | 2018 |
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice.
Topics: Animals; Anticonvulsants; Cannabinoid Receptor Agonists; Diazepam; Disease Models, Animal; Dose-Resp | 2018 |
Paradoxical kinesia induced by appetitive 50-kHz ultrasonic vocalizations in rats depends on glutamatergic mechanisms in the inferior colliculus.
Topics: Animals; Appetitive Behavior; Catalepsy; Diazepam; Disease Models, Animal; GABA Modulators; Glutamic | 2018 |
Anxiolytic effect of anacardic acids from cashew (Anacardium occidentale) nut shell in mice.
Topics: Anacardic Acids; Anacardium; Animals; Anti-Anxiety Agents; Antioxidants; Anxiety; Catalase; Diazepam | 2018 |
FGIN-1-27, an agonist at translocator protein 18 kDa (TSPO), produces anti-anxiety and anti-panic effects in non-mammalian models.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Female; I | 2018 |
Repeated diazepam administration reversed working memory impairments and glucocorticoid alterations in the prefrontal cortex after short but not long alcohol-withdrawal periods.
Topics: Alcoholism; Animals; Anxiety; Central Nervous System Depressants; Cyclic AMP Response Element-Bindin | 2018 |
Clarified Açaí (
Topics: Animals; Anticonvulsants; Cells, Cultured; Complex Mixtures; Diazepam; Disease Models, Animal; Euter | 2018 |
Benzodiazepine-refractory status epilepticus, neuroinflammation, and interneuron neurodegeneration after acute organophosphate intoxication.
Topics: Animals; Antidotes; Brain; Diazepam; Disease Models, Animal; Humans; Interneurons; Male; Nerve Agent | 2018 |
Diazepam suppresses the stress-induced dopaminergic release in the amygdala of methamphetamine-sensitized rat.
Topics: Amygdala; Animals; Behavior, Animal; Conditioning, Operant; Diazepam; Disease Models, Animal; Dopami | 2018 |
Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Benzeneacetamides; Calcium Channel Blockers; Carbama | 2018 |
Cunaniol-elicited seizures: Behavior characterization and electroencephalographic analyses.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Electroencephalography; Pen | 2018 |
Diazepam as attenuator of pain induced by dentin hypersensitivity in rats exposed to stress.
Topics: Animals; Dentin; Dentin Sensitivity; Diazepam; Disease Models, Animal; Male; Microscopy, Electron, S | 2019 |
Prophylactic potential of memantine against soman poisoning in rats.
Topics: Acetylcholinesterase; Animals; Antidotes; Atropine; Behavior, Animal; Chemical Warfare Agents; Choli | 2019 |
Diazepam Inhibits Post-Traumatic Neurogenesis and Blocks Aberrant Dendritic Development.
Topics: Animals; Brain Injuries; Cell Movement; Cell Proliferation; Cell Shape; Dendrites; Diazepam; Disease | 2019 |
Molecular mechanism of tuberoinfundibular peptide of 39 on glucocorticoid receptor mediated glutamate/GABA imbalance and cerebral abnormalities against cognitive deficit model.
Topics: Animals; Cognitive Dysfunction; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; | 2019 |
Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury.
Topics: Adrenocorticotropic Hormone; Animals; Anxiety; Anxiety Disorders; Brain Concussion; Corticosterone; | 2019 |
Lateral septum inhibition reduces motivation for cocaine: Reversal by diazepam.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Diazepam; Disease Models, Animal; Dop | 2020 |
Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy.
Topics: Animals; Anticonvulsants; Brain Waves; Diazepam; Disease Models, Animal; Drug Combinations; Electroe | 2019 |
Increased sensitivity to psychostimulants and GABAergic drugs in Lsamp-deficient mice.
Topics: Alprazolam; Animals; Behavior, Animal; Cell Adhesion Molecules, Neuronal; Central Nervous System Dep | 2019 |
Sensitivity to diazepam after a single session of forced swim stress in weaning Wistar rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Resp | 2018 |
Diazepam inhibited lipopolysaccharide (LPS)-induced pyroptotic cell death and alleviated pulmonary fibrosis in mice by specifically activating GABA
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Diazepam; Disease Models, Animal; Humans; Inf | 2019 |
One hour of pilocarpine-induced status epilepticus is sufficient to develop chronic epilepsy in mice, and is associated with mossy fiber sprouting but not neuronal death.
Topics: Animals; Cell Death; Diazepam; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Mossy Fibers, H | 2013 |
The effect of levetiracetam on status epilepticus-induced neuronal death in the rat hippocampus.
Topics: Animals; Behavior, Animal; Cell Death; Diazepam; Disease Models, Animal; Drug Therapy, Combination; | 2013 |
A benzodiazepine impairs the neurogenic and behavioural effects of fluoxetine in a rodent model of chronic stress.
Topics: Animals; Antidepressive Agents; Benzodiazepines; Brain-Derived Neurotrophic Factor; Diazepam; Diseas | 2013 |
Effects of agomelatine in a murine model of obsessive-compulsive disorder: interaction with meta-chlorophenylpiperazine, bicuculline, and diazepam.
Topics: Acetamides; Animals; Antidepressive Agents; Behavior, Animal; Bicuculline; Diazepam; Disease Models, | 2013 |
Coumarin compounds of Biebersteinia multifida roots show potential anxiolytic effects in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Chromatography, Liquid; Coumaric Acids; Coumarins; Diazepam; | 2013 |
Effects of transcranial focal electrical stimulation alone and associated with a sub-effective dose of diazepam on pilocarpine-induced status epilepticus and subsequent neuronal damage in rats.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Deep Brain Stimulation; Diazepam; Diseas | 2013 |
The anticonvulsant and sedative effects of Gladiolus dalenii extracts in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dose-Respon | 2013 |
Anxiolytic-like effect of N-n-butyl-3-methoxyquinoxaline-2-carboxamide (60) in experimental mouse models of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Resp | 2013 |
GABA-A receptor modulators alter emotionality and hippocampal theta rhythm in an animal model of long-lasting anxiety.
Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Electroencephalography; Emotions; GABA Antagonis | 2013 |
Diazepam treatment blocks the elevation of hippocampal activity and the accelerated proliferation of hippocampal neural stem cells after focal cerebral ischemia in mice.
Topics: Animals; Brain Ischemia; Cell Proliferation; Diazepam; Disease Models, Animal; Electrophysiology; GA | 2013 |
Defensive burying test in postweaning rats: use of a small round chamber.
Topics: Aging; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Fe | 2013 |
Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Electroencephalograp | 2013 |
Anxiolytic-like effects of mitragynine in the open-field and elevated plus-maze tests in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Diazepam; Disease Models, Animal; Do | 2014 |
Prior antipsychotic drug treatment prevents response to novel antipsychotic agent in the methylazoxymethanol acetate model of schizophrenia.
Topics: Allosteric Regulation; Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Diazepam; Disea | 2014 |
The effect of GABAmimetics on the duration of immobility in the forced swim test in albino mice.
Topics: Alprazolam; Animals; Depression; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; | 2014 |
Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Blood-Brain Barrier; Brain; | 2014 |
Proconvulsant effects of estriol, the third estrogen, in the mouse PTZ-kindling model.
Topics: Animals; Anticonvulsants; Clomiphene; Convulsants; Diazepam; Disease Models, Animal; Estriol; Female | 2014 |
Development of status epilepticus, sustained calcium elevations and neuronal injury in a rat survival model of lethal paraoxon intoxication.
Topics: Animals; Anticonvulsants; Atropine; Brain; Calcium; Diazepam; Disease Models, Animal; Electroencepha | 2014 |
The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling.
Topics: Animals; Anxiety; Brain-Derived Neurotrophic Factor; Colon; Curcumin; Cyclic AMP Response Element-Bi | 2015 |
The blockade of transient receptor potential ankirin 1 (TRPA1) signalling mediates antidepressant- and anxiolytic-like actions in mice.
Topics: Acetanilides; Acrolein; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Anim | 2014 |
Plurality of anxiety and depression alteration mechanism by oleanolic acid.
Topics: alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Antidepressive Agents; Brain; Brain-Derived Neur | 2014 |
Effects of repetitive exposure to anesthetics and analgesics in the Tg2576 mouse Alzheimer's model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analgesics; Anesthetics; A | 2014 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumaze | 2014 |
Sensory integration in mouse insular cortex reflects GABA circuit maturation.
Topics: Animals; Autistic Disorder; Cerebral Cortex; Diazepam; Disease Models, Animal; GABAergic Neurons; Gl | 2014 |
Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anxiety; Benzodioxoles; Diazepam; Disease Models, Animal; D | 2014 |
Potential mechanisms involved in the anticonvulsant effect of walnut extract on pentylenetetrazole-induced seizure.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2014 |
Anxiolytic-like effects of alverine citrate in experimental mouse models of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Diazepam; Disease Models, Animal; Dose-Res | 2014 |
Mitochondrial instability during regional ischemia-reperfusion underlies arrhythmias in monolayers of cardiomyocytes.
Topics: Animals; Animals, Newborn; Arrhythmias, Cardiac; Cell Culture Techniques; Diazepam; Disease Models, | 2015 |
Anticonvulsant activity of the ethanolic extract of Punica granatum L. seed.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Lythra | 2015 |
Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Brain; Brain Waves; Bridged-Ring Compounds; Diaz | 2014 |
Co-administration of subtherapeutic diazepam enhances neuroprotective effect of COX-2 inhibitor, NS-398, after lithium pilocarpine-induced status epilepticus.
Topics: Animals; Anticonvulsants; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diazepam; Disease Models, A | 2015 |
Low doses of ethanol markedly potentiate the anti-seizure effect of diazepam in a mouse model of difficult-to-treat focal seizures.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Drug Compounding; Drug Synergism; | 2014 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrod | 2015 |
Effective termination of status epilepticus by rational polypharmacy in the lithium-pilocarpine model in rats: Window of opportunity to prevent epilepsy and prediction of epilepsy by biomarkers.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrodes, Implanted; Electroencephalog | 2015 |
The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Cells, Cultured; Citalopram; Diazepam; Disease Models, Animal | 2015 |
Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Age Factors; Analysis of Variance; Animals; Anticonvulsants; Cognition Disorders; Diazepam; Disease | 2015 |
Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish.
Topics: Allylglycine; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Fructose; Levetiracetam; M | 2015 |
Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.
Topics: Animals; Anticonvulsants; Bridged-Ring Compounds; Calcium; Cells, Cultured; Diazepam; Disease Models | 2015 |
Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection.
Topics: Animals; Body Weight; Diazepam; Disease Models, Animal; Female; GABA Modulators; Gene Expression Reg | 2015 |
Behavioral consequences of predator stress in the rat elevated T-maze.
Topics: Analysis of Variance; Animals; Antiemetics; Cats; Diazepam; Disease Models, Animal; Male; Maze Learn | 2015 |
Status epilepticus induction has prolonged effects on the efficacy of antiepileptic drugs in the 6-Hz seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Levetiracetam; Male; Mice | 2015 |
Immediate Epileptogenesis after Kainate-Induced Status Epilepticus in C57BL/6J Mice: Evidence from Long Term Continuous Video-EEG Telemetry.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 2015 |
Phosphatase inhibition prevents the activity-dependent trafficking of GABAA receptors during status epilepticus in the young animal.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cells, Cultured; Diazepam; Disease Models, Animal; Enzym | 2015 |
Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Anticonvulsants; Apoptosis; Brain; Cell Death; Di | 2015 |
Fluoxetine and diazepam acutely modulate stress induced-behavior.
Topics: Aggression; Animals; Behavior, Animal; Diazepam; Disease Models, Animal; Female; Fluoxetine; GABA Mo | 2016 |
Alterations in hippocampal myelin and oligodendrocyte precursor cells during epileptogenesis.
Topics: Animals; Cell Differentiation; Diazepam; Disease Models, Animal; Epilepsy; Hippocampus; Muscarinic A | 2015 |
Forebrain-independent generation of hyperthermic convulsions in infant rats.
Topics: Animals; Animals, Newborn; Anticonvulsants; Body Temperature; Denervation; Diazepam; Disease Models, | 2016 |
High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit.
Topics: Animals; Antidepressive Agents; Azepines; Benzamides; Brain-Derived Neurotrophic Factor; Central Ner | 2015 |
Modulation of brain glutamate dehydrogenase as a tool for controlling seizures.
Topics: Animals; Anticonvulsants; Brain; Deamination; Diazepam; Disease Models, Animal; Enzyme Inhibitors; G | 2015 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D | 2016 |
Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments.
Topics: Amnesia; Animals; Avoidance Learning; Behavior, Animal; Cognition; Cognition Disorders; Diazepam; Di | 2016 |
Sustained Effects of Developmental Exposure to Ethanol on Zebrafish Anxiety-Like Behaviour.
Topics: Animals; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Embryo, Nonmammalian; Environm | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Amygdala Hyperactivity in MAM Model of Schizophrenia is Normalized by Peripubertal Diazepam Administration.
Topics: Action Potentials; Administration, Oral; Amygdala; Animals; Animals, Newborn; Anti-Anxiety Agents; A | 2016 |
Interleukin-1 receptor is a target for adjunctive control of diazepam-refractory status epilepticus in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistant Epilepsy; Hippocampus; In | 2016 |
Selective corticotropin-releasing factor 1 receptor antagonist E2508 has potent antidepressant-like and anxiolytic-like properties in rodent models.
Topics: Acetylcholine; Administration, Oral; Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety Di | 2016 |
Low dose X-irradiation mitigates diazepam induced depression in rat brain.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Depression; Diazepam; Disease Models, Animal | 2016 |
Diazepam reduces excitability of amygdala and further influences auditory cortex following sodium salicylate treatment in rats.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Auditory Cortex; Diazepam; Disease Models, Animal; Drug Eval | 2016 |
Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Diazepam; Disease Models, Animal; Down-Regulation; | 2016 |
Anxiolytic activity of the neuroprotective peptide HLDF-6 and its effects on brain neurotransmitter systems in BALB/c and C57BL/6 mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Diazepam; Disease Models, Animal; Dose-Response Relati | 2016 |
Behavioral and genotoxic evaluation of rosmarinic and caffeic acid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Caffeic Acids; Cinnamates; Comet Assay; Depsides; | 2016 |
Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cerebral Cortex; Diazepam; Diclof | 2016 |
Autonomic changes induced by provocative motion in rats bred for high (HAB) and low (LAB) anxiety-related behavior: Paradoxical responses in LAB animals.
Topics: Animals; Anticonvulsants; Anxiety; Autonomic Nervous System; Body Temperature; Breeding; Diazepam; D | 2016 |
Anxiolytic properties of N-acetylcysteine in mice.
Topics: Acetylcysteine; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Body Temperature; Dark | 2017 |
Humanin ameliorates diazepam-induced memory deficit in mice.
Topics: Alzheimer Disease; Animals; Anticonvulsants; Cognition; Diazepam; Disease Models, Animal; Intracellu | 2017 |
Exogenous daytime melatonin modulates response of adolescent mice in a repeated unpredictable stress paradigm.
Topics: Age Factors; Animals; Anti-Anxiety Agents; Antioxidants; Behavior, Animal; Biomarkers; Brain; Chroni | 2017 |
Antianxiety activity guided isolation and characterization of bergenin from Caesalpinia digyna Rottler roots.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzopyrans; Caesalpinia; Chemical Fraction | 2017 |
The anxiolytic-like effect of rutin in rats involves GABAA receptors in the basolateral amygdala.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Basolateral Nuclear Complex; Diazepam; Disease Models, Animal | 2017 |
Propylparaben applied after pilocarpine-induced status epilepticus modifies hippocampal excitability and glutamate release in rats.
Topics: Action Potentials; Animals; Anticonvulsants; Cell Count; Diazepam; Disease Models, Animal; Electric | 2017 |
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Animal; Male; Motor Activity; Oligo | 2017 |
Topiramate reduces basal anxiety and relieves ethanol withdrawal-induced anxious behaviors in male rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Diazepam; Disease Models | 2017 |
Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Bicuculline; Diazepam; Differential Thr | 2008 |
Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice.
Topics: Acamprosate; Alcohol Deterrents; Alcohol Withdrawal Seizures; Alcohols; Analysis of Variance; Animal | 2008 |
Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain Injuries; Diazepam; Disease Models, A | 2008 |
Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus.
Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Caspase 3; Cell Death; Ceramides; Diazepam; Di | 2008 |
Evaluation of the repeated open-space swim model of depression in the mouse.
Topics: Adaptation, Psychological; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; | 2008 |
Resistance to antiepileptic drugs and expression of P-glycoprotein in two rat models of status epilepticus.
Topics: Amygdala; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B; Diazepam; Disease | 2008 |
Rebound insomnia induced by abrupt withdrawal of hypnotics in sleep-disturbed rats.
Topics: Animals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Sch | 2008 |
Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.
Topics: Analysis of Variance; Anesthetics; Animals; Arginine; Diazepam; Disease Models, Animal; Dose-Respons | 2009 |
A simple quantitative method for analyzing electrographic status epilepticus in rats.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; | 2009 |
[Effects of Semen Ziziphi Spinosae on the anxiety behavior of the yin deficiency mice].
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Diazepam; Disease Models, Animal; Dr | 2008 |
Limiting effect of diazepam on Lewis Lung carcinoma metastasis in anxious male mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carcinoma, Lewis Lung; Diazepam; Disease Models, Animal; Lung | 2009 |
A KCNQ channel opener for experimental neonatal seizures and status epilepticus.
Topics: Aminopyridines; Animals; Animals, Newborn; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-R | 2009 |
Influence of diazepam on different behavioral states of sleep-waking cycle.
Topics: Animals; Cats; Diazepam; Disease Models, Animal; Electroencephalography; Hypnotics and Sedatives; Sl | 2009 |
EEG stages predict treatment response in experimental status epilepticus.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Disease Progressio | 2009 |
Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways.
Topics: Animals; Anticonvulsants; Cyproheptadine; Diazepam; Disease Models, Animal; Dose-Response Relationsh | 2009 |
Central action of Araucaria angustifolia seed lectin in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2009 |
Anxiolytic-like effects and safety profile of a tryptic hydrolysate from bovine alpha s1-casein in rats.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; C | 2009 |
Microemulsion based intranasal delivery system for treatment of insomnia.
Topics: Administration, Intranasal; Alprazolam; Animals; Diazepam; Disease Models, Animal; Drug Compounding; | 2009 |
High seizure frequency prior to antiepileptic treatment is a predictor of pharmacoresistant epilepsy in a rat model of temporal lobe epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Respons | 2010 |
Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors.
Topics: Acetaminophen; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Behavior, Animal; Cannabino | 2009 |
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety | 2009 |
Buspirone, chlordiazepoxide and diazepam effects in a zebrafish model of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzodiazepines; Buspirone; Chlordiazepoxid | 2009 |
Treatment of early and late kainic acid-induced status epilepticus with the noncompetitive AMPA receptor antagonist GYKI 52466.
Topics: Animals; Anticonvulsants; Behavior, Animal; Benzodiazepines; Blood Pressure; Diazepam; Disease Model | 2010 |
Acute effect of Copaifera reticulata Ducke copaiba oil in rats tested in the elevated plus-maze: an ethological analysis.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Balsams; Diazepam; Disease Models, Animal; Dose-Response Rela | 2009 |
Early-life blockade of 5-HT(1A) receptors alters adult anxiety behavior and benzodiazepine sensitivity.
Topics: Age Factors; Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Diazepam; Dis | 2010 |
Qualitative analysis of hippocampal plastic changes in rats with epilepsy supplemented with oral omega-3 fatty acids.
Topics: Administration, Oral; Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine | 2010 |
Implication of 5-HT2 receptor subtypes in the mechanism of action of the GABAergic compound etifoxine in the four-plate test in Swiss mice.
Topics: Amphetamines; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepa | 2010 |
Modeling withdrawal syndrome in zebrafish.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal; Ethanol; Exploratory | 2010 |
Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Cerebrovascular Circulation; Chromatography, L | 2010 |
Tolerance, sensitization and dependence to diazepam in Balb/c mice exposed to a novel open space anxiety test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Animal; Dose-Response Relationship, | 2010 |
Anxiolytic-like effect of Aronia melanocarpa fruit juice in rats.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Beverages; Diazepam; Disease Models, Animal; Dose-Re | 2009 |
Enhanced expression of the neuronal K+/Cl- cotransporter, KCC2, in spontaneously depressed Flinders Sensitive Line rats.
Topics: Animals; Central Nervous System Agents; Cerebellum; Cerebral Cortex; Depressive Disorder; Diazepam; | 2010 |
Diphenyl diselenide-induced seizures in rat pups: possible interaction with GABAergic system.
Topics: Acetanilides; Animals; Animals, Newborn; Benzene Derivatives; Diazepam; Disease Models, Animal; Dose | 2010 |
The control of kainic acid-induced status epilepticus.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2010 |
Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus.
Topics: Animals; Blotting, Western; Brain Injuries; Calcium Channel Blockers; Calcium Signaling; Chlorides; | 2010 |
Examining face and construct validity of a noninvasive model of panic disorder in Lister-hooded rats.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Body Temperature; Diazepam; Disease Models, Animal; Escape R | 2010 |
Parallel anxiolytic-like and antinociceptive actions of diazepam in the anterior basolateral amygdala and dorsal periaqueductal gray.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Area Under Curve; Behavior, Animal; Diazepam; Disea | 2010 |
Microstructure of rat behavioral response to anxiety in hole-board.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Explorato | 2010 |
Influence of etoricoxib on anticonvulsant activity of phenytoin and diazepam in experimental seizure models in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug I | 2010 |
Benzodiazepine receptor agonists cause drug-specific and state-specific alterations in EEG power and acetylcholine release in rat pontine reticular formation.
Topics: Acetylcholine; Animals; Azabicyclo Compounds; Brain; Diazepam; Disease Models, Animal; Dose-Response | 2010 |
Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice.
Topics: Animals; Anticonvulsants; Berberine; Diazepam; Disease Models, Animal; Dose-Response Relationship, D | 2010 |
Isolation of anxiolytic principle from ethanolic root extract of Cardiospermum halicacabum.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Glucoside | 2011 |
Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats.
Topics: Acetylcholinesterase; Acute Disease; Animals; Antioxidants; Behavior, Animal; Brain; Chronic Disease | 2010 |
Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition.
Topics: Animals; Animals, Newborn; Biophysics; Brain-Derived Neurotrophic Factor; Carbazoles; Cocaine; Cocai | 2010 |
Reversal of memory deficits by Coriandrum sativum leaves in mice.
Topics: Aging; Animals; Anticholesteremic Agents; Avoidance Learning; Brain; Cholesterol; Cholinesterase Inh | 2011 |
GABAergic regulation of auditory sensory gating in low- and high-anxiety rats submitted to a fear conditioning procedure.
Topics: Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Benzodiazepines; Bicuculline; Clonixin; Co | 2010 |
Cellular correlates of anxiety in CA1 hippocampal pyramidal cells of 5-HT1A receptor knockout mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Disease Models, Animal; Excitatory Post | 2011 |
A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+ tf/J mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Autistic Disorder; Behavior, Animal; Di | 2011 |
The benzodiazepine diazepam demonstrates the usefulness of Syrian hamsters as a model for anxiety testing: evaluation of other classes of anxiolytics in comparison to diazepam.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Cricetinae; Diazepam; Disease Models, Anima | 2011 |
Further characterization of the predictive validity of the Brattleboro rat model for antipsychotic efficacy.
Topics: Animals; Antipsychotic Agents; Chlorpromazine; Diazepam; Disease Models, Animal; Female; Imipramine; | 2011 |
Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.
Topics: Amidohydrolases; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodioxoles; Cannabinoid Recepto | 2011 |
T-pattern analysis of diazepam-induced modifications on the temporal organization of rat behavioral response to anxiety in hole board.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Behavioral Research; Diazepam; Disease Mode | 2011 |
Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cation Transport Proteins; Diazepam; Disease Models, | 2011 |
The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats.
Topics: Amygdala; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Ani | 2011 |
Effects of alcohol on the acquisition and expression of fear-potentiated startle in mouse lines selectively bred for high and low alcohol preference.
Topics: Alcohol-Related Disorders; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Animal; | 2011 |
A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia.
Topics: Allosteric Regulation; Amphetamine; Animals; Benzodiazepines; Diazepam; Disease Models, Animal; Dopa | 2011 |
Modeling epileptogenesis and temporal lobe epilepsy in a non-human primate.
Topics: Analysis of Variance; Animals; Anticonvulsants; Benzoxazines; Callithrix; Diazepam; Disease Models, | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni | 2011 |
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Di | 2011 |
A critical test of the hippocampal theta model of anxiolytic drug action.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Biophysics; Diazepam; Disease Models, A | 2012 |
A cell-free extract from human adipose stem cells protects mice against epilepsy.
Topics: Adipose Tissue; Animals; Animals, Newborn; Anticonvulsants; Blood-Brain Barrier; Cell Extracts; Cell | 2011 |
Susceptibility to the long-term anxiogenic effects of an acute stressor is mediated by the activation of the glucocorticoid receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anti-Anxiety Agents; Cocaine; | 2011 |
Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Benzoquinones; Brain; Cyclic GMP; Diazepam; | 2011 |
Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage.
Topics: Animals; Anticonvulsants; Benzodiazepines; Cholinesterase Inhibitors; Diazepam; Disease Models, Anim | 2011 |
Psychological stress induces alterations in temporomandibular joint ultrastructure in a rat model of temporomandibular disorder.
Topics: Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Cartilage, Articular; Collagen; Diazepam; | 2011 |
Anxiolytic-like effects of human amniotic fluid and its fatty acids in Wistar rats.
Topics: Amniotic Fluid; Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Diestrus; Disease Models, | 2011 |
Pharmacological evaluation of the adequacy of marble burying as an animal model of compulsion and/or anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Anxiety Disorders; Behavior, Animal; Benzothiazoles; Carbolin | 2011 |
Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region.
Topics: Adrenergic beta-3 Receptor Antagonists; Analysis of Variance; Animals; Anti-Anxiety Agents; Body Tem | 2011 |
Anxiolytic-like activity of MGS0039, a selective group II mGlu receptor antagonist, is serotonin- and GABA-dependent.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Bridged Bicyclo Compounds; Diazepam; Dicarboxylic Acids; Dise | 2011 |
Anticonvulsant activity of the methanolic extract of Justicia extensa T. Anders.
Topics: Acanthaceae; Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Female; Male; | 2011 |
Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding.
Topics: Animals; Anticonvulsants; Autoradiography; Azides; Benzodiazepines; Carbolines; Convulsants; Diazepa | 2012 |
On the edge: pharmacological evidence for anxiety-related behavior in zebrafish larvae.
Topics: Animals; Anxiety; Caffeine; Cues; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug | 2012 |
Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 2011 |
Beneficial effects of benzodiazepine diazepam on chronic stress-induced impairment of hippocampal structural plasticity and depression-like behavior in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Brain-Derived Neurotrophic Factor; Corticosteron | 2012 |
Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain Ischemia; CA1 Region, Hippocampal; Diazepam; Di | 2012 |
Social fear conditioning: a novel and specific animal model to study social anxiety disorder.
Topics: Animals; Anti-Anxiety Agents; Conditioning, Psychological; Diazepam; Disease Models, Animal; Dose-Re | 2012 |
[Effect of GB-115 dipeptide on anxiety in rats with model benzodiazepine withdrawal syndrome].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Anxiety Diso | 2011 |
Increased anxiety-like behaviors in rats experiencing chronic inflammatory pain.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Chronic Disease; Dark Adaptation; Diaze | 2012 |
Further characterization of the prototypical nociceptin/orphanin FQ peptide receptor agonist Ro 64-6198 in rodent models of conflict anxiety and despair.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chlordiazepoxide; Conflict, Psychological; | 2012 |
Pharmacological treatment of fragile X syndrome with GABAergic drugs in a knockout mouse model.
Topics: Analysis of Variance; Anesthetics; Animals; Diazepam; Disease Models, Animal; Dose-Response Relation | 2012 |
Evaluation of anxiolytic effect and withdrawal anxiety in chronic intermittent diazepam treatment in rats.
Topics: Amines; Animals; Anti-Anxiety Agents; Anxiety; Cyclohexanecarboxylic Acids; Diazepam; Disease Models | 2012 |
[Anti-inflammatory effects of amitriptyline, diazepam and mebicar using model of acute carrageenan-induced paw edema in rats].
Topics: Amitriptyline; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biureas; Carrageenan; Diazepam; Dis | 2011 |
Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: evaluating its anticonvulsant and anxiolytic potential.
Topics: Alkaloids; Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Convulsants; Diazepam; Disease Mo | 2012 |
The elevated T-maze task as an animal model to simultaneously investigate the effects of drugs on long-term memory and anxiety in mice.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Biperiden; Diazepam; Disease Models, An | 2012 |
A mouse kindling model of perimenstrual catamenial epilepsy.
Topics: 5-alpha Reductase Inhibitors; Animals; Diazepam; Disease Models, Animal; Epilepsy; Female; Finasteri | 2012 |
Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.
Topics: Animals; Anticonvulsants; Benzoxazines; Brain; Brain Mapping; Diazepam; Disease Models, Animal; Epil | 2012 |
Central effect of crocin on penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Brain; Carotenoids; Diazepam; Disease Models, Animal; Dose-Response Relati | 2012 |
An affective disorder in zebrafish with mutation of the glucocorticoid receptor.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Anti-Anxiety Agents; Arginine; Brain; | 2013 |
The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Neurons; Adrenocorticotropic Hormone; alpha-Meth | 2012 |
Factors affecting outcomes of pilocarpine treatment in a mouse model of temporal lobe epilepsy.
Topics: Age Factors; Animals; Anticonvulsants; Atropine; Body Weight; Diazepam; Disease Models, Animal; Epil | 2012 |
Sequel of spontaneous seizures after kainic acid-induced status epilepticus and associated neuropathological changes in the subiculum and entorhinal cortex.
Topics: Animals; Anticonvulsants; Astrocytes; Diazepam; Disease Models, Animal; Drug Resistance; Entorhinal | 2012 |
Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam.
Topics: Acetamides; Aniline Compounds; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Anim | 2012 |
Synthesis and pharmacological investigation of 2-(4-dimethylaminophenyl)-3,5-disubstituted thiazolidin-4-ones as anticonvulsants.
Topics: Acetamides; Animals; Anticonvulsants; Benzamides; Diazepam; Disease Models, Animal; Epilepsy; Male; | 2012 |
Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Carbazoles; Diazepam; Disease Models, A | 2012 |
Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, | 2012 |
N (w) -propyl-L-arginine (L-NPA) reduces status epilepticus and early epileptogenic events in a mouse model of epilepsy: behavioural, EEG and immunohistochemical analyses.
Topics: Animals; Arginine; Brain Waves; Dentate Gyrus; Diazepam; Disease Models, Animal; Gliosis; Immunohist | 2012 |
Evaluation of anti convulsant activity of aerial parts of Phyllanthus longiflorus heyne ex hook.
Topics: Administration, Oral; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2012 |
Rapid epileptogenesis in the mouse pilocarpine model: video-EEG, pharmacokinetic and histopathological characterization.
Topics: Analysis of Variance; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Rela | 2012 |
Possible involvement of histone acetylation in the development of emotional resistance to stress stimuli in mice.
Topics: Acetylation; Analysis of Variance; Animals; Anti-Anxiety Agents; Diazepam; Disease Models, Animal; D | 2012 |
A higher inherent trait for fearfulness is associated with increased anxiety-like behaviours and diazepam sensitivity in Japanese quail.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Coturnix; Diazepam; D | 2013 |
Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.
Topics: Analysis of Variance; Animals; Benzodiazepines; Brain Ischemia; Diazepam; Disease Models, Animal; Dr | 2012 |
Estrous cycle variation in anxiolytic-like effects of topiramate in Wistar rats in two animal models of anxiety-like behavior.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Conditioning, Operant; Diazepam; Disease Models, Animal; Dose | 2013 |
A depressive phenotype induced by Bacille Calmette Guérin in 'susceptible' animals: sensitivity to antidepressants.
Topics: Animals; Antidepressive Agents; BCG Vaccine; Chronic Disease; Depression; Desipramine; Diazepam; Dis | 2013 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Ritualistic chewing behavior induced by mCPP in the rat is an animal model of obsessive compulsive disorder.
Topics: Animals; Behavior, Animal; Clomipramine; Diazepam; Disease Models, Animal; Dopamine Antagonists; Flu | 2013 |
Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relat | 2013 |
Characterization of pharmacoresistance to benzodiazepines in the rat Li-pilocarpine model of status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Chi-Square Distribution; Diazepam; Disease Models, Animal | 2002 |
Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Death; Diazepam; Disease Models, Animal; Electr | 2002 |
Antiepileptic drugs and apoptotic neurodegeneration in the developing brain.
Topics: Animals; Anticonvulsants; Apoptosis; Brain; Brain-Derived Neurotrophic Factor; Diazepam; Disease Mod | 2002 |
Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Brain; Chlormethiazole; Clorgyline; Diazepam; Diseas | 2003 |
Reduction of inflammation in rats by diazepam: tolerance development.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Corticosterone; Diazepam; Disease Models, Animal; Do | 2003 |
22-kHz ultrasonic vocalization in rats as an index of anxiety but not fear: behavioral and pharmacological modulation of affective state.
Topics: Animals; Anxiety; Behavior, Animal; Buspirone; Carbolines; Conditioning, Classical; Diagnosis, Diffe | 2003 |
Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice.
Topics: Animals; Animals, Outbred Strains; Anti-Anxiety Agents; Anxiety; Carbolines; Dextroamphetamine; Diaz | 2003 |
Posture and balance responses to a sensory challenge are related to anxiety in mice.
Topics: Animals; Anticonvulsants; Anxiety Disorders; Diazepam; Disease Models, Animal; Male; Mice; Mice, Inb | 2003 |
Tail-swing behavior: a novel animal model for anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Desipramine; Diazepam; Disease Models, Animal; Haloperidol; Immo | 2003 |
Neuronal activity-dependent increase of net matrix metalloproteinase activity is associated with MMP-9 neurotoxicity after kainate.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Avian Proteins; Basigin; Blood Protein | 2003 |
Hippocampal N-acetyl aspartate levels do not mirror neuronal cell densities in creatine-supplemented epileptic rats.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cell Count; Creatine; Diazepam; Disease Models, Animal; Epi | 2003 |
Diazepam prophylaxis for bicuculline-induced seizures: a rat dose-response model.
Topics: Action Potentials; Animals; Bicuculline; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 2004 |
Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia.
Topics: Animals; Anti-Dyskinesia Agents; Anticonvulsants; Biperiden; Brain; Diazepam; Disease Models, Animal | 2003 |
Effects of acute and chronic fluoxetine and diazepam on freezing behavior induced by electrical stimulation of dorsolateral and lateral columns of the periaqueductal gray matter.
Topics: Animals; Diazepam; Disease Models, Animal; Electric Stimulation; Escape Reaction; Fluoxetine; Immobi | 2004 |
Pharmacological plasticity of GABA(A) receptors at dentate gyrus synapses in a rat model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Electric Conductivity; Ep | 2004 |
Effects of fosphenytoin on nerve agent-induced status epilepticus.
Topics: Animals; Anticonvulsants; Atropine; Chemical Warfare Agents; Diazepam; Disease Models, Animal; Dose- | 2004 |
The anxiolytic-like activity of AIDA (1-aminoindan-1,5-dicarboxylic acid), an mGLu 1 receptor antagonist.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Conflict, Psychological | 2004 |
Abnormal benzodiazepine and zinc modulation of GABAA receptors in an acquired absence epilepsy model.
Topics: Androstenes; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Disease Models, Animal; Enzyme Inh | 2004 |
Does amygdaloid corticotropin-releasing hormone (CRH) mediate anxiety-like behaviors? Dissociation of anxiogenic effects and CRH release.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; Bombesin; Bra | 2004 |
Diazepam reduces brain lesion size in a photothrombotic model of focal ischemia in rats.
Topics: Animals; Anticonvulsants; Body Weight; Brain Ischemia; Cerebral Infarction; Diazepam; Disease Models | 2004 |
The effects of angelica essential oil in three murine tests of anxiety.
Topics: Angelica sinensis; Animals; Anti-Anxiety Agents; Anxiety; Darkness; Diazepam; Disease Models, Animal | 2004 |
Does rat global transient cerebral ischemia serve as an appropriate model to study emotional disturbances?
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Depression; Diazepam; Disea | 2004 |
Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol.
Topics: Alcoholism; Animals; Diazepam; Discrimination, Psychological; Disease Models, Animal; Drug Interacti | 2005 |
Acute effect of an extract of Ambrosia paniculata (Willd.) O. E. Schultz (mugwort) in several models of experimental epilepsy.
Topics: Ambrosia; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Diazepa | 2004 |
Ketamine-induced changes in rat behaviour: a possible animal model of schizophrenia. Test of predictive validity.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Behavior | 2004 |
Characterization of the tetanus toxin model of refractory focal neocortical epilepsy in the rat.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Diazepam; Disease Models, Animal; Electroencephal | 2005 |
Benzodiazepine effect of (125)I-iomazenil-benzodiazepine receptor binding and serum corticosterone level in a rat model.
Topics: Animals; Brain; Corticosterone; Diazepam; Disease Models, Animal; Flumazenil; Male; Radionuclide Ima | 2005 |
Administration of diazepam during status epilepticus reduces development and severity of epilepsy in rat.
Topics: Action Potentials; Amygdala; Animals; Anticonvulsants; Behavior, Animal; Chi-Square Distribution; Di | 2005 |
The anxiolytic-like effect of 5-HT1B receptor ligands in rats: a possible mechanism of action.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzamides; Conflict, Psychological; Diazepam; Disea | 2005 |
Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Dose-Response Relation | 2005 |
Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety Disorders; Avoidance L | 2005 |
Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Desipramine; Diazepam; Disease Model | 2005 |
Attenuation of benzodiazepine withdrawal anxiety in the rat by serotonin antagonists.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Interpers | 2005 |
A new assay of thermal-based avoidance test in freely moving mice.
Topics: Analgesics, Opioid; Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Biological A | 2005 |
Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Mod | 2005 |
Novel oral drug administration in an animal model of neuroleptic therapy.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Behavior, Animal; Body Weight; Brain; Clozapine | 2005 |
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
Topics: Amygdala; Analgesics, Opioid; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Benzamides; | 2006 |
A single session of emotional stress produces anxiety in Wistar rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Mod | 2006 |
A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Diazepam; Disease Models, Animal; Dopamine; Electrophysio | 2005 |
Influence of the post-ovariectomy time frame on the experimental anxiety and the behavioural actions of some anxiolytic agents.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; | 2006 |
Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Anticonvuls | 2006 |
Anxiolytic-like activity of agomelatine and melatonin in three animal models of anxiety.
Topics: Acetamides; Animals; Anti-Anxiety Agents; Arousal; Brain; Buspirone; Chronotherapy; Conditioning, Cl | 2006 |
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
Topics: Anesthetics; Animals; Brain; Brain Injuries; Cell Survival; Cognition Disorders; Diazepam; Disease M | 2006 |
Activation of Rho after traumatic brain injury and seizure in rats.
Topics: Animals; Anticonvulsants; Brain Injuries; Cerebral Cortex; Diazepam; Disease Models, Animal; Drug In | 2006 |
Mouse strain differences in autonomic responses to stress.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Autonomic Nervous System; Autonomic Nervous System | 2006 |
Pharmacological evaluation of the stress-induced social avoidance model of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Brain; Buspirone; Chlordiazepoxide; Diazepam; Disea | 2006 |
Both alpha2 and alpha3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Central Nervous System | 2006 |
Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Anxiety; Behav | 2006 |
Anticonvulsant properties of hypothermia in experimental status epilepticus.
Topics: Animals; Anticonvulsants; Body Temperature; Brain; Cold Temperature; Dentate Gyrus; Diazepam; Diseas | 2006 |
Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: Possible mechanism of action.
Topics: Animals; Anticonvulsants; Convulsants; Cyclooxygenase Inhibitors; Diazepam; Disease Models, Animal; | 2006 |
The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Therapy, Combination; Electroenceph | 2006 |
The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder.
Topics: Animals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Mi | 2006 |
Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Fructo | 2007 |
Lithium-methomyl induced seizures in rats: a new model of status epilepticus?
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Synergism; Electroencephalography; | 2007 |
Anticonvulsant and anxiolytic activity of FrPbAII, a novel GABA uptake inhibitor isolated from the venom of the social spider Parawixia bistriata (Araneidae: Araneae).
Topics: Analysis of Variance; Animals; Anticonvulsants; Anxiety; Behavior, Animal; Bicuculline; Choice Behav | 2006 |
Anti-anxiety effects of Apocynum venetum L. in the elevated plus maze test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Apocynum; Behavior, Animal; Buspirone; Diazepam; Disease Mode | 2007 |
Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumaz | 2006 |
Effect of novel AMPA antagonist, NS1209, on status epilepticus. An experimental study in rat.
Topics: Amygdala; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Dr | 2007 |
Anxiolytic effect of saponins from Panax quinquefolium in mice.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Darkness; Diazepam; Disease Mod | 2007 |
Sleep-related epilepsy in the A/J mouse.
Topics: Alleles; Animals; Anticonvulsants; Chromosomes, Mammalian; Diazepam; Disease Models, Animal; Electro | 2007 |
In vivo pharmacological characterization of the structurally novel, potent, selective mGlu2/3 receptor agonist LY404039 in animal models of psychiatric disorders.
Topics: Amino Acids; Amphetamine; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Cyclic | 2007 |
Anxiolytic-like effects of oleamide in group-housed and socially isolated mice.
Topics: Aggression; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Diazepam; Disease Models, Anim | 2007 |
Anxiety-like and exploratory behaviors of isolation-reared mice in the staircase test.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Central N | 2007 |
Ziprasidone, diazepam, or the combination for prevention of cocaine toxicity in a mouse model.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Confidence Intervals; Diazepam; Disease Models, Animal; | 2007 |
Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats.
Topics: Amygdala; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Brain Damage, Chronic; D | 2007 |
Decreased sensitivity to thermal pain in rats bred for high anxiety-related behaviour is attenuated by citalopram or diazepam treatment.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Anxiet | 2007 |
Contrasting effects of diazepam and repeated restraint stress on latent inhibition in mice.
Topics: Amphetamine; Animals; Anti-Anxiety Agents; Antipsychotic Agents; Behavior, Animal; Central Nervous S | 2007 |
Pharmacological modulation of anxiety-related behaviors in the murine Suok test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Circadian Rhythm; Diazepam; Disease Models, | 2007 |
Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors.
Topics: Animals; Anticonvulsants; Antidotes; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Re | 2007 |
The effects of prolonged rose odor inhalation in two animal models of anxiety.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Choice Behavior; Diaz | 2007 |
Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits.
Topics: Analgesics; Anesthetics, Combined; Anesthetics, Intravenous; Animals; Animals, Newborn; Anti-Anxiety | 2007 |
Anxiolytic-like and antidepressant-like effects produced by the selective 5-HT6 receptor antagonist SB-258585 after intrahippocampal administration to rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Depression; Diazepam; Disease Models, | 2007 |
Behavioral effects of 6-bromoflavanone and 5-methoxy-6,8-dibromoflavanone as anxiolytic compounds.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Mod | 2008 |
Anxiogenic effects of cocaine withdrawal in zebrafish.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Cocaine; Diazepam; Disease Models, Anim | 2008 |
Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Diazepam; Disease Models, Animal; D | 2007 |
A combination of ketamine and diazepam synergistically controls refractory status epilepticus induced by cholinergic stimulation.
Topics: Animals; Cerebral Cortex; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug S | 2008 |
A substance in broad beans (Vicia faba) is protective against experimentally induced convulsions in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Chromatography, Thin Layer; Diazepam; Disease Models | 2008 |
Treatment with haloperidol and diazepam alters GABA(A) receptor density in the rat brain.
Topics: Animals; Antipsychotic Agents; Autoradiography; Benzodiazepines; Binding Sites; Brain; Diazepam; Dis | 2008 |
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Topics: Analgesics; Animals; Brain; Capsaicin; Chronic Disease; Diazepam; Disease Models, Animal; Fluorobenz | 2008 |
Use of antipsychotics to treat cocaine toxicity?
Topics: Animals; Antipsychotic Agents; Cocaine; Cocaine-Related Disorders; Diazepam; Disease Models, Animal; | 2008 |
Alterations of GABA A-receptor function and allosteric modulation during development of status epilepticus.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepines; Diazepam; Disease Models, Animal; | 2008 |
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Re | 2008 |
Analysis of the chronic intake of and withdrawal from diazepam on emotional reactivity and sensory information processing in rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Behavior, Animal; D | 2008 |
Effective treatments of prolonged status epilepticus in developing rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, | 2008 |
Pharmacological validation of a chronic social stress model of depression in rats: effects of reboxetine, haloperidol and diazepam.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Behavior, Animal; Depress | 2008 |
Tactile-induced ultrasonic vocalization in the rat: a novel assay to assess anti-migraine therapies in vivo.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diazepam; Diseas | 2008 |
Comparison of anti-conflict drug effects in three experimental animal models of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Conflict, Psychological; Diazepam; Disease Models, Animal; Dr | 1981 |
Enhancing GABAergic transmission reverses the aversive state in rats induced by electrical stimulation of the periaqueductal grey region.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Animal; Drug Interactions; Electric | 1982 |
Alprazolam in a biochemical model of depression.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Depression; Diazepam; Disease Models, Ani | 1982 |
Animal psychopharmacological models: use of conflict behavior in predicting clinical effects of anxiolytics and their mechanism of action.
Topics: Animals; Anti-Anxiety Agents; Arousal; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Co | 1982 |
Brain benzodiazepine receptors and their rapid changes after seizures in the Mongolian gerbil.
Topics: Animals; Binding Sites; Brain; Diazepam; Disease Models, Animal; Epilepsy; Gerbillinae; Receptors, D | 1980 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, An | 1983 |
Stress ulcer accompanying subarachnoid hemorrhage--a new rat model.
Topics: Animals; Cimetidine; Diazepam; Disease Models, Animal; Gastric Mucosa; Male; Pentobarbital; Phenytoi | 1983 |
Comparison of effects of diazepam on barbiturate and on ethanol withdrawal.
Topics: Animals; Behavior, Animal; Cats; Diazepam; Disease Models, Animal; Ethanol; Female; Humans; Male; Pe | 1983 |
The pentylenetetrazol model of anxiety detects withdrawal from diazepam in rats.
Topics: Animals; Anxiety; Diazepam; Discrimination Learning; Disease Models, Animal; Humans; Male; Pentylene | 1983 |
Visual evoked potentials in a rabbit model of hepatic encephalopathy. I. Sequential changes and comparisons with drug-induced comas.
Topics: Animals; Diazepam; Disease Models, Animal; Electrodes; Electroencephalography; Evoked Potentials, Vi | 1984 |
Alterations in cerebellar glutamic acid decarboxylase (GAD) activity in a genetic model of torsion dystonia (rat).
Topics: Animals; Brain; Cerebellum; Diazepam; Disease Models, Animal; Dystonia; Glutamate Decarboxylase; His | 1984 |
Modification of the anticonvulsant efficacy of diazepam by Ro-15-1788 in the kindled amygdaloid seizure model.
Topics: Amygdala; Animals; Anticonvulsants; Benzodiazepinones; Diazepam; Disease Models, Animal; Dose-Respon | 1982 |
Effects of selected drugs on spontaneously occurring abnormal behavior in beagles.
Topics: Amobarbital; Animals; Antidepressive Agents; Arousal; Behavior, Animal; Chlordiazepoxide; Diazepam; | 1983 |
Experimental chronic epilepsy in rats: a screening method for antiepileptic drugs.
Topics: Animals; Anticonvulsants; Chlorides; Chronic Disease; Clonazepam; Diazepam; Disease Models, Animal; | 1983 |
Effect of hyperbilirubinemia on the pharmacokinetics of diazepam in the rat.
Topics: Animals; Diazepam; Disease Models, Animal; Half-Life; Humans; Hyperbilirubinemia; Hyperbilirubinemia | 1980 |
A study of the action of anticonvulsant drugs on an experimental model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Electric Stimulation; Epi | 1980 |
Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors.
Topics: Amygdala; Animals; Benzodiazepines; Cerebral Cortex; Diazepam; Disease Models, Animal; Electroshock; | 1980 |
Pharmacological characteristics of abnormal behavior induced by harmine with special reference to tremor in mice.
Topics: 5-Hydroxytryptophan; Alkaloids; Animals; Antidepressive Agents; Behavior, Animal; Diazepam; Disease | 1981 |
Effect of antiepileptic drugs and an anticonvulsant on epileptiform activity induced by antibodies to ganglioside.
Topics: Action Potentials; Aminooxyacetic Acid; Animals; Anticonvulsants; Cobalt; Diazepam; Disease Models, | 1982 |
Effect of diazepam (Valium) on chronic stress-induced hypertension in the rat.
Topics: Animals; Blood Pressure; Body Weight; Diazepam; Disease Models, Animal; Hypertension; Male; Rats; St | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled cortical seizures.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Disease Models, Animal; Epilepsy; Mal | 1981 |
Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of diazepam, bretazenil and abecarnil.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Carbolines; Diazepam; Disease Models, Animal; Drug Tole | 1995 |
(+)-WIN 55,212-2, a novel cannabinoid receptor agonist, exerts antidystonic effects in mutant dystonic hamsters.
Topics: Analgesics; Animals; Benzoxazines; Cricetinae; Diazepam; Disease Models, Animal; Dose-Response Relat | 1994 |
Respiratory drive during status epilepticus and its treatment: comparison of diazepam and lorazepam.
Topics: Animals; Diazepam; Disease Models, Animal; Epilepsy, Tonic-Clonic; Hydrogen-Ion Concentration; Loraz | 1995 |
Observations of novel behaviors as indices of ethanol withdrawal-induced anxiety.
Topics: Animals; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Ethanol; Exploratory Behavior; | 1993 |
Behavioural and pharmacological characterisation of the elevated "zero-maze" as an animal model of anxiety.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Chl | 1994 |
Selective serotonin re-uptake inhibitors decrease schedule-induced polydipsia in rats: a potential model for obsessive compulsive disorder.
Topics: Animals; Clomipramine; Conditioning, Operant; Desipramine; Diazepam; Disease Models, Animal; Drinkin | 1993 |
Gender differences in diazepam withdrawal syndrome in mice.
Topics: Animals; Body Weight; Castration; Diazepam; Disease Models, Animal; Estrogens; Female; Flumazenil; I | 1994 |
Perinatally protein-deprived rats and reactivity to anxiolytic drugs in the plus-maze test: an animal model for screening antipanic agents?
Topics: Animals; Anti-Anxiety Agents; Anxiety; Conflict, Psychological; Diazepam; Disease Models, Animal; Do | 1993 |
Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: a possible rat model of PMS anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Electrosh | 1993 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Var | 1993 |
Effect of diazepam on muscle weakness in a model of myasthenia gravis in rats.
Topics: Animals; Bungarotoxins; Diazepam; Disease Models, Animal; Female; Lip; Male; Muscle Contraction; Mus | 1993 |
The elevated T maze, a new experimental model of anxiety and memory: effect of diazepam.
Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Memory; Rats; | 1993 |
Effect of the beta-carboline abecarnil on spinal reflexes in mice and on muscle tone in genetically spastic rats: a comparison with diazepam.
Topics: Animals; Anticonvulsants; Carbolines; Diazepam; Disease Models, Animal; Electromyography; Female; Ma | 1993 |
Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two-compartment black and white text box.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; A | 1995 |
Long-duration self-sustained epileptiform activity in the hippocampal-parahippocampal slice: a model of status epilepticus.
Topics: Animals; Diazepam; Disease Models, Animal; Electric Stimulation; Entorhinal Cortex; Hippocampus; In | 1995 |
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, | 1996 |
Effects of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1 -H-1-benzazepin-8-yl)-1-propanone fumarate (TAK-147), a novel acetylcholinesterase inhibitor, on impaired learning and memory in animal models.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Benzazepines; Brain; Diazepam; Disease Models, | 1996 |
The neurochemical pathology of thiamine deficiency: GABAA and glutamateNMDA receptor binding sites in a goat model.
Topics: Alcoholism; Amprolium; Animals; Brain Chemistry; Diazepam; Disease Models, Animal; Dizocilpine Malea | 1996 |
Suppression of splenic natural killer cell activity in a mouse model for binge drinking. II. Role of the neuroendocrine system.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Animals; Azides; Benzodiazepi | 1996 |
Effects of (-)-baclofen, clonazepam, and diazepam on tone exposure-induced hyperexcitability of the inferior colliculus in the rat: possible therapeutic implications for pharmacological management of tinnitus and hyperacusis.
Topics: Acoustic Stimulation; Animals; Auditory Threshold; Baclofen; Clonazepam; Diazepam; Disease Models, A | 1996 |
Effect of chronic diazepam treatment on footshock-induced ultrasonic vocalization in adult male rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Animal; Dose- | 1995 |
Heterogeneity in the performance of outbred Sprague-Dawley rats in an elevated-plus maze test: a possible animal model for anxiety disorder.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Male; Rat | 1996 |
High-performance liquid chromatographic determination of midazolam in rat brain.
Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Chromatography, High Pressure Liquid; Diazepam; Disea | 1996 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dizocilpine Maleate; Drug I | 1997 |
Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Conflict, Psychological; Diazepam; Disease | 1997 |
Local perfusion of diazepam attenuates interictal and ictal events in the bicuculline model of epilepsy in rats.
Topics: Administration, Topical; Animals; Bicuculline; Cerebral Cortex; Diazepam; Disease Models, Animal; Do | 1997 |
Pharmacological evaluation of IQM-95,333, a highly selective CCKA receptor antagonist with anxiolytic-like activity in animal models.
Topics: Amylases; Animals; Anorexia; Anti-Anxiety Agents; Benzodiazepinones; Carbamates; Cholecystokinin; De | 1997 |
[Assessment of anti-tremorogenic drugs--nicotine-induced tail-tremor model].
Topics: Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Clonazepam; Diazepam; Disease Models, Ani | 1997 |
Effects of diazepam and buspirone on the behaviour of wild voles (Microtus socialis) in two models of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Arvicolinae; Behavior, Animal; Buspirone; Diazepam; Disease M | 1997 |
Benzodiazepine receptors influence spinal cord evoked potentials and edema following trauma to the rat spinal cord.
Topics: Animals; Diazepam; Disease Models, Animal; Edema; Evoked Potentials; GABA-A Receptor Agonists; Male; | 1997 |
Interictal and ictal activity in the rat cobalt/pilocarpine model of epilepsy decreased by local perfusion of diazepam.
Topics: Animals; Anticonvulsants; Cobalt; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy | 1997 |
The connection between absence-like seizures and hypothermia induced by penicillin: possible implication on other animal models of petit mal epilepsy.
Topics: Animals; Anticonvulsants; Body Temperature; Cerebral Cortex; Diazepam; Disease Models, Animal; Elect | 1997 |
BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 1997 |
Effect of narcotic agents and of bleeding on systemic and renal haemodynamics in healthy and CCl4-treated cirrhotic rats.
Topics: Animals; Blood Pressure; Butyrophenones; Carbon Tetrachloride; Diazepam; Disease Models, Animal; Dru | 1997 |
Diazepam suppresses sleep apneas in rats.
Topics: Analysis of Variance; Animals; Diazepam; Disease Models, Animal; Electroencephalography; Electromyog | 1998 |
Effect of 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole HCl (MKC-242), a novel 5-HT1A-receptor agonist, on aggressive behavior and marble burying behavior in mice.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Diazepam; Dioxanes; Dioxoles; Disease | 1998 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod | 1998 |
Opioid receptor mediated anticonvulsant effect of pentazocine.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relati | 1998 |
Effects of acute and repeated dose administration of caffeine and pentoxifylline on diazepam-induced mouse behavior in the hole-board test.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Caffeine; Diazepam; Disease Models, Animal | 1999 |
Alcohol responsiveness, hyperreactivity, and motor restlessness in an animal model for attention-deficit hyperactivity disorder.
Topics: Alcohol Drinking; Animals; Attention Deficit Disorder with Hyperactivity; Brain Chemistry; Diazepam; | 1999 |
A gene promotes anxiety in mice-and also in scientists.
Topics: Animals; Anxiety Disorders; Diazepam; Disease Models, Animal; Mice; Mice, Mutant Strains; Models, Ps | 1999 |
NMDA- but not kainate-mediated events reduce efficacy of some antiepileptic drugs against generalized tonic-clonic seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 1999 |
Felbamate in experimental model of status epilepticus.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Diazepam; Disease Models, Animal; Dose-Response Relationshi | 2000 |
Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 2000 |
Impact of diazepam on pineal-adrenal axis in an avian model.
Topics: Adrenal Glands; Animals; Columbidae; Corticosterone; Diazepam; Disease Models, Animal; Epinephrine; | 2000 |
The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety.
Topics: Aminopyridines; Animals; Anxiety; Cyclohexane Monoterpenes; Diazepam; Disease Models, Animal; Dose-R | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy | 2000 |
Self-sustaining status epilepticus: a condition maintained by potentiation of glutamate receptors and by plastic changes in substance P and other peptide neuromodulators.
Topics: Age Factors; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electroencephalography; Ele | 2000 |
Balance control and posture differences in the anxious BALB/cByJ mice compared to the non anxious C57BL/6J mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Carbolines; Diazepam; Disease Models, Anima | 2000 |
Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Caudate Nucleus; Cocaine; Conditioning, Operant; Diaze | 2001 |
Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Disease Models, Animal; Hypertens | 2001 |
Anticonvulsant effect of nimodipine alone and in combination with diazepam and phenytoin in a mouse model of status epilepticus.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diazepam; Disease Models, Animal; Drug Therapy, | 2000 |
Differential role of dopamine D1 and D2 receptors in isoniazid-induced vacuous chewing movements.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Anticonvulsants; Antipsychotic | 2000 |
Excessive lever pressing following post-training signal attenuation in rats: a possible animal model of obsessive compulsive disorder?
Topics: Animals; Behavior, Animal; Conditioning, Operant; Cues; Diazepam; Disease Models, Animal; Fluoxetine | 2001 |
Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Bro | 2001 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; | 2001 |
[An experimental study of the spectrum of individual psychotropic activity of clozapine (Leponex)].
Topics: Animals; Antipsychotic Agents; Cats; Clozapine; Diazepam; Dibenzazepines; Disease Models, Animal; Ha | 1975 |
Myoclonus developing after vermisectomy in photosensitive Papio papio.
Topics: Animals; Cerebellum; Diazepam; Disease Models, Animal; Electroencephalography; Haplorhini; Ketamine; | 1978 |
[Epileptogenic action of intra-amygdaloid injection of kainic acid].
Topics: Amygdala; Animals; Diazepam; Disease Models, Animal; Hippocampus; Injections; Kainic Acid; Male; Pyr | 1978 |
A primate model for testing anticonvulsant drugs.
Topics: Allyl Compounds; Animals; Anticonvulsants; Carbamazepine; Chromatography, Gas; Diazepam; Disease Mod | 1975 |
A comparison of the effects of chronically administered diazepam and phenobarbital and learning in the Papio papio model of epilepsy.
Topics: Animals; Diazepam; Disease Models, Animal; Haplorhini; Learning; Papio; Phenobarbital; Seizures; Sti | 1977 |
[Pathogenesis of stereotyped behavior].
Topics: Animals; Behavior; Caudate Nucleus; Diazepam; Disease Models, Animal; gamma-Aminobutyric Acid; Halop | 1979 |
The hippocampal slice: a system for studying the pharmacology of seizures and for screening anticonvulsant drugs.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electroenc | 1977 |
The influence of aldosterone and anticonvulsant drugs on electroencephalographic and clinical disturbances induced by the spirolactone derivative, potassium canrenoate.
Topics: Aldosterone; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dogs; Electroencepha | 1975 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Pharmacological modification of arrhythmias after experimentally induced acute myocardial infarction. Drugs acting on the nervous system.
Topics: Acute Disease; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Chlordiaz | 1975 |
Kindling and electrode effects on the benzodiazepine receptors density of olfactory bulb and hippocampus after olfactory bulb kindling.
Topics: Animals; Diazepam; Disease Models, Animal; Electric Stimulation; Epilepsy, Generalized; Hippocampus; | 1992 |
Neurochemical changes associated with the action of acute administration of diazepam in reversing the behavioral paradigm conditioned emotional response (CER).
Topics: Amino Acids; Animals; Anxiety; Aspartic Acid; Behavior, Animal; Biogenic Monoamines; Brain; Conditio | 1992 |
Pharmacokinetics of diazepam in the rat: influence of a carbon tetrachloride-induced hepatic injury.
Topics: Administration, Oral; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Proteins; Ca | 1992 |
A rodent model of focally evoked self-sustaining status epilepticus.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Electroencephalography; Lithium; Male; Piloc | 1992 |
Acoustic startle induced ultrasonic vocalization in the rat: a novel animal model of anxiety?
Topics: Animals; Anti-Anxiety Agents; Anxiety; Appetite Depressants; Arousal; Carbolines; Diazepam; Disease | 1991 |
Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms.
Topics: Acetylcholine; Animals; Anti-Anxiety Agents; Anticonvulsants; Antidotes; Atropine; Brain Chemistry; | 1991 |
Acute administration of diazepam and buspirone in rats trained on conflict schedules having different degrees of predictability.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Conditioning, Psychological; Conflict, Psychologic | 1991 |
Alterations of GABA-A and dopamine D-2 brain receptors in dogs with portal-systemic encephalopathy.
Topics: Animals; Brain; Diazepam; Dimethylnitrosamine; Disease Models, Animal; Dogs; Dopamine; Glutamate Dec | 1991 |
Effects of pharmacological manipulation of GABAergic neurotransmission in a new mutant hamster model of paroxysmal dystonia.
Topics: Animals; Baclofen; Carbamazepine; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; gamma-Amin | 1991 |
[Experimental study of the effects of fenibut and seduxen on fetal development in the last third of pregnancy].
Topics: Abortion, Threatened; Animals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; E | 1991 |
Brain concentrations of benzodiazepines are elevated in an animal model of hepatic encephalopathy.
Topics: Animals; Anti-Anxiety Agents; Brain; Chromatography, High Pressure Liquid; Diazepam; Disease Models, | 1990 |
Lack of anxiety in an animal model of depression with cholinergic supersensitivity.
Topics: Animals; Anxiety; Depression; Diazepam; Disease Models, Animal; Female; Male; Motor Activity; Parasy | 1991 |
Animal model for investigating the anxiogenic effects of self-administered cocaine.
Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Conditioning, Operant; Conflict, Psychological; Diazepa | 1991 |
Validation of aversion towards open space and height as a measure of anxiety in the genetically based animal model of depression.
Topics: Animals; Anxiety; Behavior, Animal; Caffeine; Depressive Disorder; Diazepam; Disease Models, Animal; | 1990 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze | 1990 |
Neuropharmacological and physiological validation of a computer-controlled two-compartment black and white box for the assessment of anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Body Temperature; Computers; Corticosterone | 1989 |
Animal model of anxiety: effect of acute diazepam treatment in the older adult genetically hypertensive rats of Koletsky type and in the older adult rats of Wistar strain.
Topics: Age Factors; Animals; Anxiety; Behavior, Animal; Body Temperature; Corticosterone; Diazepam; Disease | 1989 |
Animal model of anxiety: effect of diazepam in the rats with cholinergic supersensitivity and reduced turnover-rate of brain norepinephrine.
Topics: Animals; Anxiety; Brain; Cholinergic Fibers; Diazepam; Disease Models, Animal; Norepinephrine; Rats | 1989 |
Development of an in vivo model for assessment of drug-induced vascular injury.
Topics: Animals; Diazepam; Disease Models, Animal; Ear; Female; Infusions, Intravenous; Lidocaine; Male; Pre | 1989 |
The sz mutant hamster: a genetic model of epilepsy or of paroxysmal dystonia?
Topics: Animals; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; Electroencephalography; Electromyog | 1989 |
Animal models of chronic anxiety and "fearlessness".
Topics: Animals; Anxiety; Brain; Cats; Diazepam; Disease Models, Animal; Fear; Female; Flumazenil; Flunitraz | 1988 |
Behavioral and 5-HT antagonist effects of ritanserin: a pure and selective antagonist of LSD discrimination in rat.
Topics: 5-Hydroxytryptophan; Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Diazepam; Disease Mode | 1985 |
Withdrawal syndrome following subchronic treatment with anxiolytic agents.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Disease Models, Animal; Exploratory Behavior; Male; Rats; Su | 1987 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, | 1986 |
Benzodiazepine/gamma-aminobutyric acid receptor deficit in the midbrain of the seizure-susceptible gerbil.
Topics: Animals; Bicuculline; Diazepam; Disease Models, Animal; Flunitrazepam; Gerbillinae; Mesencephalon; M | 1985 |
Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptors.
Topics: Animals; Anxiety; Diazepam; Disease Models, Animal; Drug Combinations; Exploratory Behavior; Male; P | 1987 |
The effects of chronic antidepressant treatment in an animal model of anxiety.
Topics: Amitriptyline; Animals; Antidepressive Agents; Anxiety; Desipramine; Diazepam; Disease Models, Anima | 1988 |
Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol.
Topics: Animals; Diazepam; Discrimination Learning; Disease Models, Animal; Flumazenil; Male; Pentylenetetra | 1988 |
Protective cardiovascular effects of diazepam in experimental acute chloroquine poisoning.
Topics: Animals; Chloroquine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclinical; Electrocardiog | 1988 |
Dependence potential of the benzodiazepines: use of animal models for assessment.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Disease Models, Animal; | 1985 |
The effect of glucose upon restitution after transient cerebral ischemia: a summary.
Topics: Animals; Blood Glucose; Brain; Diazepam; Disease Models, Animal; Insulin; Ischemic Attack, Transient | 1985 |
Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Evaluation, Preclini | 1985 |
[Clinical prevention and therapy of Sudeck's syndrome. Bases of animal experiments].
Topics: Adult; Animals; Biopsy; Diazepam; Disease Models, Animal; Ergoloid Mesylates; Female; Histocytochemi | 1971 |
The effect of diazepam (Valium) and nitrazepam (Mogadon) on picrotoxin induced seizures in rabbits.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Electrocardiography; Electroencephalogra | 1970 |
Superiority of clonazepam over diazepam in experimental epilepsy.
Topics: Animals; Anticonvulsants; Bemegride; Benzazepines; Cats; Cobalt; Diazepam; Disease Models, Animal; E | 1973 |
[Reflex algodystrophy and fractures of the hand].
Topics: Animals; Arteries; Diazepam; Disease Models, Animal; Ergoloid Mesylates; Female; Fractures, Bone; Ha | 1973 |
Diazepam prevents and aborts lidocaine convulsions in monkeys.
Topics: Animals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Haplorhini; Injections, | 1974 |
The effects of diphenylhydantoin, phenobarbital, and diazepam on the penicillin-induced epileptogenic focus in the rat.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Diazepam; Disease Models, Animal; Electroence | 1974 |
Proceedings: Isolation-induced timidity in mice as a measure of anxiolytic activity of drugs.
Topics: Animals; Anxiety Disorders; Barbiturates; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Diaze | 1974 |
Quantitative study of alcohol withdrawal signs in mice.
Topics: Alcoholism; Animals; Barbiturates; Behavior, Animal; Chlorpromazine; Diazepam; Disease Models, Anima | 1973 |
Paroxysmal manifestations generated by a cobalt-induced focus localized within the mesencephalic reticular formation in cats with bilaterally destroyed habenular nuclei.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Cobalt; Diazepam; Disease Models, Animal; Electroen | 1974 |
The anticonvulsant effects of phenobarbital, diphenylhydantoin and two benzodiazepines in the baboon, Papio papio.
Topics: Animals; Anticonvulsants; Benzazepines; Diazepam; Disease Models, Animal; Electrodes; Electroencepha | 1970 |
Observations on models used for the evaluation of antiarrhythmic drugs.
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutte | 1971 |