diazepam has been researched along with Delayed Effects, Prenatal Exposure in 99 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The long-term consequences of neonatal exposure to diazepam (DZP) on behavioral abilities and local cerebral glucose utilization (LCGU) in 12 brain regions involved in the control of memory and anxiety were studied in adult rats." | 7.69 | Long-term consequences of neonatal exposure to diazepam on cerebral glucose utilization, learning, memory and anxiety. ( Desor, D; Humbert, AC; Nehlig, A; Schroeder, H, 1997) |
| "Schizophrenia is believed to arise from an interaction of genetic predisposition and adverse environmental factors, with stress being a primary variable." | 5.39 | Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia. ( Du, Y; Grace, AA, 2013) |
| "Prenatal stress may induce intrauterine growth retardation, but it is not known whether a treatment with the anxiolytic benzodiazepine, diazepam may interfere with this phenomenon." | 5.30 | Prenatal stress induces body weight deficit and behavioural alterations in rats: the effect of diazepam. ( Di Leo, F; Drago, F; Giardina, L, 1999) |
| "The long-term consequences of neonatal exposure to diazepam (DZP) on behavioral abilities and local cerebral glucose utilization (LCGU) in 12 brain regions involved in the control of memory and anxiety were studied in adult rats." | 3.69 | Long-term consequences of neonatal exposure to diazepam on cerebral glucose utilization, learning, memory and anxiety. ( Desor, D; Humbert, AC; Nehlig, A; Schroeder, H, 1997) |
| "Long-term behavioral effects of a low dose of diazepam (1 mg/kg body weight) or chlorpromazine (2." | 3.68 | Impact of prenatal low-dose diazepam or chlorpromazine on reflex and motor development and inhibitory-learning. ( Hassmannová, J; Josífko, M; Myslivecek, J, 1991) |
| " Given the known anti-aggressive influence of acute doses of diazepam it was hypothesized that, when administered during pregnancy, this drug would change the adult social behaviour." | 3.67 | An ethological analysis of the influence of perinatally-administered diazepam on murine behaviour. ( Benton, D; Brain, PF; Grimm, VE; McAllister, KH, 1984) |
| "Exposure to ethanol during pregnancy results in the alteration of (3H)-diazepam binding to synaptosomal neocortical membranes from the rat offspring." | 3.67 | [Effects of prenatal exposure to alcohol on the binding of H3-diazepam to the synaptic membranes of the cerebral hemisphere cortex at various stages of ontogenesis in the rat offspring]. ( Zhulin, VV, 1988) |
| "The results of five experiments showed that exposure to diazepam, hypoxia and monosodium glutamate during the prenatal or early postnatal period of rapid brain development may result in different behavioral consequences depending on the timing of the exposure rather than the nature of the agent." | 3.67 | Differential vulnerability of male and female rats to the timing of various perinatal insults. ( Frieder, B; Grimm, VE, 1985) |
| "Schizophrenia is believed to arise from an interaction of genetic predisposition and adverse environmental factors, with stress being a primary variable." | 1.39 | Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia. ( Du, Y; Grace, AA, 2013) |
| " At lower dosage DZ seems to inhibit lipofuscinogenesis, at highest dosage DZ accumulates non-degradable residues." | 1.30 | Effects of perinatal diazepam exposure on the liver of rats. ( Haider, SG; Hartwig, HG; Mariam, T; Shahryar, S; Siddiqui, A; Tan, LH, 1998) |
| "Prenatal stress may induce intrauterine growth retardation, but it is not known whether a treatment with the anxiolytic benzodiazepine, diazepam may interfere with this phenomenon." | 1.30 | Prenatal stress induces body weight deficit and behavioural alterations in rats: the effect of diazepam. ( Di Leo, F; Drago, F; Giardina, L, 1999) |
| "Experiments examining seizure sensitivity were conducted on adult male offspring exposed to diazepam at 1." | 1.28 | Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex. ( Bitran, D; Kellogg, CK; Primus, RJ, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 33 (33.33) | 18.7374 |
| 1990's | 43 (43.43) | 18.2507 |
| 2000's | 17 (17.17) | 29.6817 |
| 2010's | 6 (6.06) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Haas, M | 1 |
| Qu, Z | 1 |
| Kim, TH | 1 |
| Vargas, E | 1 |
| Campbell, K | 1 |
| Petrou, S | 1 |
| Tan, SS | 1 |
| Reid, CA | 1 |
| Heng, J | 1 |
| Du, Y | 3 |
| Grace, AA | 3 |
| Lakehayli, S | 2 |
| Said, N | 2 |
| Battas, O | 1 |
| Hakkou, F | 2 |
| Tazi, A | 2 |
| El Khachibi, M | 1 |
| El Ouahli, M | 1 |
| Nadifi, S | 1 |
| Martire, M | 6 |
| Altobelli, D | 2 |
| Cannizzaro, C | 9 |
| Maurizi, S | 1 |
| Preziosi, P | 2 |
| Steardo, L | 2 |
| Cannizzaro, E | 7 |
| Gagliano, M | 7 |
| Mineo, A | 6 |
| Provenzano, G | 3 |
| Morgulis, MS | 1 |
| Palermo-Neto, J | 1 |
| D'Amico, M | 1 |
| Monastero, R | 1 |
| Nicosia, A | 1 |
| Giardina, L | 2 |
| Di Leo, F | 2 |
| Medico, M | 1 |
| Mazzola, C | 1 |
| Genazzani, AA | 1 |
| Drago, F | 2 |
| Tazumi, T | 1 |
| Hori, E | 1 |
| Uwano, T | 1 |
| Umeno, K | 1 |
| Tanebe, K | 1 |
| Tabuchi, E | 1 |
| Ono, T | 1 |
| Nishijo, H | 1 |
| Plescia, F | 1 |
| La Barbera, M | 1 |
| Mantia, G | 1 |
| Cannizzaro, G | 2 |
| Kellogg, CK | 15 |
| Kenjarski, TP | 1 |
| Pleger, GL | 4 |
| Frye, CA | 1 |
| Tonkiss, J | 1 |
| Galler, J | 1 |
| Picard, N | 2 |
| Guenin, S | 2 |
| Perrin, Y | 2 |
| Hilaire, G | 2 |
| Larnicol, N | 2 |
| Grimm, VE | 7 |
| McAllister, KH | 1 |
| Brain, PF | 1 |
| Benton, D | 1 |
| Weber, LW | 1 |
| Schmahl, WG | 1 |
| Watanabe, Y | 2 |
| Shibuya, T | 2 |
| Salafsky, B | 2 |
| Hill, HF | 2 |
| Kellogg, C | 2 |
| Ison, JR | 2 |
| Miller, RK | 4 |
| Frieder, B | 5 |
| Epstein, S | 1 |
| Simmons, RD | 3 |
| Rivas, F | 1 |
| Hernandez, A | 1 |
| Cantu, JM | 1 |
| Meshorer, A | 1 |
| Gai, N | 2 |
| Assael, M | 1 |
| Chisholm, J | 1 |
| Fujii, T | 1 |
| Yamamoto, N | 1 |
| Fuchino, K | 1 |
| Ikeda, H | 1 |
| Hrazdira, I | 1 |
| Sulcova, A | 1 |
| Kellnerova, R | 1 |
| Huskova, B | 1 |
| Sabatino, M | 1 |
| Nishikouri, Y | 1 |
| Márquez-Orozco, A | 7 |
| Hernandez-Alvarez, LA | 3 |
| Márquez-Orozco, MC | 7 |
| Schlumpf, M | 7 |
| Lichtensteiger, W | 7 |
| Ramseier, H | 1 |
| Pérez-Laso, C | 2 |
| Valencia, A | 1 |
| Rodríguez-Zafra, M | 3 |
| Calés, JM | 2 |
| Guillamón, A | 2 |
| Segovia, S | 2 |
| Schreiber, AA | 2 |
| Frei, K | 2 |
| Jaiswal, AK | 3 |
| Bhattacharya, SK | 3 |
| García Márquez, P | 1 |
| Baz Alonso, MJ | 1 |
| Mata-Santibánez, MV | 1 |
| Parmar, R | 2 |
| Taylor, MK | 1 |
| Inglefield, JR | 1 |
| Bitran, D | 3 |
| Olschowka, JA | 1 |
| Fisher, CE | 1 |
| Hughes, RN | 1 |
| Driscoll, P | 1 |
| Ferré, P | 1 |
| Fernández-Teruel, A | 1 |
| Levi de Stein, M | 1 |
| Wolfman, C | 1 |
| Medina, J | 1 |
| Tobeña, A | 1 |
| Escorihuela, RM | 1 |
| Mangiapane, N | 1 |
| Inderbitzin, S | 1 |
| Lauber, ME | 1 |
| Singh, Y | 2 |
| Singh, M | 2 |
| Schroeder, H | 1 |
| Humbert, AC | 1 |
| Desor, D | 1 |
| Nehlig, A | 1 |
| Tan, LH | 1 |
| Mariam, T | 1 |
| Shahryar, S | 1 |
| Siddiqui, A | 1 |
| Haider, SG | 1 |
| Hartwig, HG | 1 |
| Bürgi, B | 1 |
| Yao, J | 1 |
| Nishio, H | 1 |
| Kasuga, S | 1 |
| Ushijima, M | 1 |
| Harada, Y | 1 |
| Carollo, A | 1 |
| Roberts, AA | 1 |
| Laegreid, L | 1 |
| Hagberg, G | 1 |
| Lundberg, A | 1 |
| Alcántara-Ortigoza, MA | 1 |
| Primus, RJ | 2 |
| Bouchot-Gamas, E | 1 |
| Fernández-Gabarrón, F | 1 |
| Barbier, P | 1 |
| Breteaudeau, J | 1 |
| Autret, E | 1 |
| Bertrand, P | 1 |
| Foussard-Blampin, O | 1 |
| Breteau, M | 1 |
| Myslivecek, J | 2 |
| Hassmannová, J | 2 |
| Josífko, M | 1 |
| Roth, Z | 1 |
| Ramseier, HR | 1 |
| Lall, SB | 1 |
| Sahoo, RN | 1 |
| Stika, L | 1 |
| Elisová, K | 1 |
| Honzáková, L | 1 |
| Hrochová, H | 1 |
| Plechatová, H | 1 |
| Strnadová, J | 1 |
| Skop, B | 1 |
| Svihovec, J | 1 |
| Váchova, M | 1 |
| Vinar, O | 1 |
| Miranda, R | 1 |
| Ceckler, T | 1 |
| Guillet, R | 1 |
| Gruen, RJ | 3 |
| Elsworth, JD | 1 |
| Roth, RH | 3 |
| Caminero, A | 1 |
| Izquierdo, MA | 1 |
| Cagiano, R | 1 |
| De Salvia, MA | 1 |
| Perischella, M | 1 |
| Renna, G | 1 |
| Tattoli, M | 1 |
| Cuomo, V | 1 |
| Deutch, AY | 2 |
| Rothe, T | 3 |
| Bigl, V | 2 |
| Miranda, RC | 1 |
| Wagner, JP | 1 |
| Zhulin, VV | 1 |
| Middleton-Price, H | 1 |
| Langer, M | 1 |
| Marczynski, TJ | 3 |
| Urbancic, M | 1 |
| Brioni, JD | 1 |
| Orsingher, OA | 1 |
| Boiadzhieva, N | 2 |
| Ovcharov, R | 1 |
| Livezey, GT | 2 |
| Radulovacki, M | 1 |
| Isaac, L | 2 |
| Retell, TM | 1 |
| Escobar, A | 1 |
2 reviews available for diazepam and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Benzodiazepines: influence on the developing brain.
Topics: Animals; Benzodiazepines; Brain; Diazepam; Female; Fetus; Motor Activity; Pregnancy; Prenatal Exposu | 1988 |
Drugs and chemicals that act on the central nervous system: interpretation of experimental evidence.
Topics: Abnormalities, Drug-Induced; Animals; Binding Sites; Brain; Central Nervous System Agents; Diazepam; | 1985 |
97 other studies available for diazepam and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Perturbations in cortical development and neuronal network excitability arising from prenatal exposure to benzodiazepines in mice.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Female; GABA Modulators; Interneurons; Mice; Mi | 2013 |
Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia.
Topics: Amphetamine; Animals; Anxiety; Central Nervous System Sensitization; Diazepam; Dopaminergic Neurons; | 2013 |
Prenatal stress alters sensitivity to benzodiazepines in adult rats.
Topics: Animals; Anti-Anxiety Agents; Conditioning, Classical; Diazepam; Female; Male; Maternal Exposure; Ma | 2015 |
Amygdala Hyperactivity in MAM Model of Schizophrenia is Normalized by Peripubertal Diazepam Administration.
Topics: Action Potentials; Administration, Oral; Amygdala; Animals; Animals, Newborn; Anti-Anxiety Agents; A | 2016 |
Prenatal stress alters diazepam withdrawal syndrome and 5HT1A receptor expression in the raphe nuclei of adult rats.
Topics: Animals; Diazepam; Electroshock; Female; GABA Modulators; Male; Pregnancy; Prenatal Exposure Delayed | 2016 |
Loss of Parvalbumin in the Hippocampus of MAM Schizophrenia Model Rats Is Attenuated by Peripubertal Diazepam.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Diazepam; Disease Models, Animal; Down-Regulation; | 2016 |
Prenatal diazepam exposure functionally alters the GABA(A) receptor that modulates [3H]noradrenaline release from rat hippocampal synaptosomes.
Topics: Allosteric Regulation; Animals; Baclofen; Bicuculline; Diazepam; Female; Fetal Proteins; GABA Agonis | 2002 |
Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated adult male rat progeny.
Topics: Age Factors; Alprazolam; Animals; Anti-Anxiety Agents; Behavior, Animal; Convulsants; Diazepam; Expl | 2002 |
Effects of in ovo and acute diazepam treatments on peripheral benzodiazepine receptors and cutaneous basophil hypersensitivity in chickens.
Topics: Animals; Anti-Anxiety Agents; Basophils; Chick Embryo; Chickens; Diazepam; Female; Hypersensitivity; | 2002 |
Neurosteroid modulation of the presynaptic NMDA receptors regulating hippocampal noradrenaline release in normal rats and those exposed prenatally to diazepam.
Topics: Animals; Diazepam; Female; Glycine; Hippocampus; Male; Norepinephrine; Pregnancy; Pregnenolone; Pren | 2003 |
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to reveal 5-HT1A receptor function.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Anti-Anxiety Agents; Behavior, Animal; Diaze | 2003 |
Long-lasting behavioral changes induced by pre- or neonatal exposure to diazepam in rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Diazepam; Female; Male; Pregnancy; Prenatal Exposure De | 2003 |
Effects of prenatal maternal stress by repeated cold environment on behavioral and emotional development in the rat offspring.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anti-Anxiety Agents; Behavior, Animal; Cold Tempera | 2005 |
Reversal of prenatal diazepam-induced deficit in a spatial-object learning task by brief, periodic maternal separation in adult rats.
Topics: Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal | 2005 |
Region-, age-, and sex-specific effects of fetal diazepam exposure on the postnatal development of neurosteroids.
Topics: Animals; Brain; Chlorides; Diazepam; Female; gamma-Aminobutyric Acid; Pregnancy; Prenatal Exposure D | 2006 |
Prenatal malnutrition alters diazepam-mediated suppression of ultrasonic vocalizations in an age dependent manner.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Temperature; Body Wei | 2007 |
Consequences of prenatal exposure to diazepam on the respiratory parameters, respiratory network activity and gene expression of alpha1 and alpha2 subunits of GABA(A) receptor in newborn rat.
Topics: Animals; Animals, Newborn; Body Temperature; Diazepam; Female; Gene Expression Regulation; Pregnancy | 2008 |
Prenatal diazepam exposure alters respiratory control system and GABAA and adenosine receptor gene expression in newborn rats.
Topics: Animals; Animals, Newborn; Diazepam; Female; GABA Modulators; Gene Expression Regulation, Developmen | 2008 |
An ethological analysis of the influence of perinatally-administered diazepam on murine behaviour.
Topics: Aggression; Animals; Behavior, Animal; Diazepam; Female; Humans; Mice; Pregnancy; Prenatal Exposure | 1984 |
The influence of prenatal diazepam treatment on the postnatal pattern of mouse brain Na, K-ATPase activity.
Topics: Animals; Brain; Diazepam; Female; Male; Mice; Pregnancy; Prenatal Exposure Delayed Effects; Sodium-P | 1983 |
Prenatal and postnatal exposure to diazepam: effects on opioid receptor binding in rat brain cortex.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Cyclazocine; Diazepam; Ethylketocyclazocine; Female; Male | 1983 |
Prenatal diazepam exposure: effects on auditory temporal resolution in rats.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Female; Growth; Hearing; Pregnancy; Prenatal Ex | 1983 |
The effects of exposure to diazepam during various stages of gestation or during lactation on the development and behavior of rat pups.
Topics: Animals; Behavior, Animal; Body Weight; Diazepam; Discrimination Learning; Female; Gestational Age; | 1984 |
Prenatal exposure to diazepam alters central and peripheral responses to stress in adult rat offspring.
Topics: Animals; Brain; Corticosterone; Diazepam; Female; Hypothalamus; Male; Nervous System; Norepinephrine | 1984 |
Acentric craniofacial cleft in a newborn female prenatally exposed to a high dose of diazepam.
Topics: Abnormalities, Drug-Induced; Diazepam; Face; Female; Humans; Infant, Newborn; Pregnancy; Prenatal Ex | 1984 |
The effect of exposure to diazepam through the placenta or through the mother's milk. Histological findings in slices of rat brain.
Topics: Animals; Brain; Diazepam; Female; Gestational Age; Maternal-Fetal Exchange; Milk; Placenta; Pregnanc | 1984 |
[Behavioral and histological effects of prenatal exposure to diazepam in rats].
Topics: Animals; Behavior, Animal; Brain; Diazepam; Female; Pregnancy; Prenatal Exposure Delayed Effects; Ra | 1983 |
Neural and behavioral consequences of prenatal exposure to diazepam.
Topics: Animals; Auditory Perceptual Disorders; Behavior, Animal; Benzodiazepines; Brain; Catecholamines; Di | 1983 |
Prenatal diazepam exposure in rats: long-lasting, receptor-mediated effects on hypothalamic norepinephrine-containing neurons.
Topics: Animals; Brain; Cerebral Cortex; Diazepam; Dopamine; Dose-Response Relationship, Drug; Female; Hippo | 1984 |
The effect of prenatal exposure to diazepam on aspects of postnatal development and behavior in rats.
Topics: Animals; Behavior, Animal; Body Weight; Diazepam; Discrimination Learning; Dose-Response Relationshi | 1982 |
Functional alterations in the hypothalamic-pituitary-thyroid axis in rats exposed prenatally to diazepam.
Topics: Animals; Body Weight; Diazepam; Female; Hypothalamo-Hypophyseal System; Male; Pregnancy; Prenatal Ex | 1983 |
[Pharmacological studies on the functional development of the central nervous system in first generation rats born to phenytoin-treated mothers (author's transl)].
Topics: Animals; Animals, Newborn; Ataxia; Birth Rate; Brain; Catalepsy; Diazepam; Eye; Feeding Behavior; Fe | 1982 |
Prenatal application of diagnostic ultrasound in mice.
Topics: Agonistic Behavior; Animals; Behavior, Animal; Birth Weight; Diazepam; Female; Male; Mice; Mice, Inb | 1995 |
Effects of desipramine and alprazolam on forced swimming behaviour of adult rats exposed to prenatal diazepam.
Topics: Alprazolam; Animals; Behavior, Animal; Depression; Desipramine; Diazepam; Electroencephalography; El | 1995 |
[Effect of prenatal administration of diazepam and buspirone on brain monoamines and avoidance learning behavior in offspring rats in relation to the influence of maternal stress caused by subcutaneous injection].
Topics: Animals; Animals, Newborn; Avoidance Learning; Biogenic Monoamines; Brain; Buspirone; Diazepam; Fema | 1995 |
Sexual activity in male mice treated prenatally with diazepam.
Topics: Animals; Copulation; Diazepam; Ejaculation; Female; Male; Mice; Pregnancy; Prenatal Exposure Delayed | 1994 |
Mating behavior of female mice treated prenatally with diazepam.
Topics: Animals; Copulation; Diazepam; Female; Litter Size; Mice; Posture; Pregnancy; Prenatal Exposure Dela | 1994 |
Diazepam treatment of pregnant rats differentially affects interleukin-1 and interleukin-2 secretion in their offspring during different phases of postnatal development.
Topics: Animals; Animals, Newborn; Diazepam; Female; Interleukin-1; Interleukin-2; Male; Pregnancy; Pregnanc | 1993 |
Perinatal administration of diazepam alters sexual dimorphism in the rat accessory olfactory bulb.
Topics: Animals; Animals, Newborn; Diazepam; Female; Male; Olfactory Bulb; Pregnancy; Prenatal Exposure Dela | 1994 |
The effect of prenatal diazepam exposure on TNF-alpha production by rat splenocytes.
Topics: Animals; Cell Division; Cells, Cultured; Concanavalin A; Cytophotometry; Diazepam; Female; Fluoresce | 1993 |
Alterations in interleukin-6 production by LPS- and Con A-stimulated mixed splenocytes, spleen macrophages and lymphocytes in prenatally diazepam-exposed rats.
Topics: Animals; Antibodies, Monoclonal; Concanavalin A; Diazepam; Female; Fluorescent Antibody Technique; I | 1993 |
Effects of gestational undernutrition, stress and diazepam treatment on spatial discrimination learning and retention in young rats.
Topics: Animals; Animals, Newborn; Diazepam; Discrimination Learning; Female; Memory; Nutrition Disorders; P | 1993 |
[Benzodiazepine withdrawal syndrome in newborn infants. Clinical cases].
Topics: Benzodiazepines; Diazepam; Female; Gestational Age; Humans; Infant, Newborn; Male; Pregnancy; Pregna | 1993 |
Testicular histological changes in mice after prenatal administration of diazepam.
Topics: Animals; Diazepam; Female; Male; Mice; Mice, Inbred Strains; Pregnancy; Prenatal Exposure Delayed Ef | 1993 |
Prenatal diazepam induced persisting downregulation of peripheral (omega 3) benzodiazepine receptors on rat splenic macrophages.
Topics: Animals; B-Lymphocytes; Binding Sites; Cell Membrane; Diazepam; Down-Regulation; Female; Isoquinolin | 1993 |
Altered stressor-induced changes in GABAA receptor function in the cerebral cortex of adult rats exposed in utero to diazepam.
Topics: Aging; Animals; Cerebral Cortex; Chlorides; Diazepam; Female; Male; Pregnancy; Prenatal Exposure Del | 1993 |
Selective effects on CRF neurons and catecholamine terminals in two stress-responsive regions of adult rat brain after prenatal exposure to diazepam.
Topics: Animals; Brain Chemistry; Catecholamines; Corticotropin-Releasing Hormone; Diazepam; Dopamine beta-H | 1993 |
Effects of diazepam and cyclohexyladenosine on open-field behavior in rats perinatally exposed to caffeine.
Topics: Adenosine; Animals; Caffeine; Diazepam; Eliminative Behavior, Animal; Emotions; Female; Grooming; Lo | 1996 |
Effects of prenatal diazepam on two-way avoidance behavior, swimming navigation and brain levels of benzodiazepine-like molecules in male Roman high- and low-avoidance rats.
Topics: Animals; Avoidance Learning; Brain Chemistry; Diazepam; Female; Genetics, Behavioral; Locomotion; Ma | 1995 |
Behavioural responsiveness to picrotoxin and desipramine in adult rats prenatally exposed to different benzodiazepine receptor agonists.
Topics: Adrenergic Uptake Inhibitors; Alprazolam; Animals; Behavior, Animal; Desipramine; Diazepam; Female; | 1995 |
Amphetamine-induced preprodynorphin mRNA expression and kappa-opioid receptor binding in basal ganglia of adult rats after prenatal exposure to diazepam.
Topics: Age Factors; Amphetamine; Analgesics; Animals; Basal Ganglia; Benzeneacetamides; Binding, Competitiv | 1997 |
Behavioural effects of prenatal diazepam administration on anxiety patterns in rats.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Female; Gestational Age; Male; Pr | 1996 |
Long-term consequences of neonatal exposure to diazepam on cerebral glucose utilization, learning, memory and anxiety.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Brain; Carbon Radioisotopes; Deoxyglucose; | 1997 |
Locomotor and antidepressant-like effects of 5-HT(1A) agonist LY 228729 in prenatally benzodiazepine-exposed rats.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Antidepressive Agents; Depressive Disorder; Diazepam; Ergo | 1998 |
Effects of perinatal diazepam exposure on the liver of rats.
Topics: Animals; Animals, Newborn; Coloring Agents; Diazepam; Female; Kupffer Cells; Lipofuscin; Liver; Male | 1998 |
Prenatal stress induces body weight deficit and behavioural alterations in rats: the effect of diazepam.
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Birth Weight; | 1999 |
Effect of prenatal diazepam, phenobarbital, haloperidol and fluoxetine exposure on foot shock induced aggression in rats.
Topics: Aggression; Animals; Diazepam; Drug Evaluation, Preclinical; Electroshock; Female; Fluoxetine; Halop | 1998 |
Sex differences in long-term consequences of prenatal diazepam exposure: possible underlying mechanisms.
Topics: Animals; Brain; Diazepam; Dose-Response Relationship, Drug; Female; GABA Modulators; Male; Neurons; | 1999 |
Diazepam-binding inhibitor/acyl-CoA-binding protein mRNA and peripheral benzodiazepine receptor mRNA in endocrine and immune tissues after prenatal diazepam exposure of male and female rats.
Topics: Adrenal Glands; Animals; Animals, Newborn; Blotting, Northern; Carrier Proteins; Diazepam; Diazepam | 2000 |
Sex-specific effects of in utero manipulation of GABA(A) receptors on pre- and postnatal expression of BDNF in rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Diazepam; Female; Flumazenil; GABA Modu | 2000 |
Prenatal stress and postnatal development of neonatal rats--sex-dependent effects on emotional behavior and learning ability of neonatal rats.
Topics: Acoustic Stimulation; Age Factors; Animals; Animals, Newborn; Anti-Anxiety Agents; Behavior, Animal; | 2001 |
Long-lasting handling affects behavioural reactivity in adult rats of both sexes prenatally exposed to diazepam.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Exploratory Behavior; Female; Handling, Psychological; Male; | 2001 |
Effect of prenatal exposure to diazepam on brain GABA(A) receptor mRNA levels in rats examined at late fetal or adult ages.
Topics: Age Factors; Animals; Brain; Brain Chemistry; Cyclophilins; Diazepam; Female; GABA Modulators; Gene | 2001 |
Neurodevelopment in late infancy after prenatal exposure to benzodiazepines--a prospective study.
Topics: Abnormalities, Drug-Induced; Anti-Anxiety Agents; Arousal; Body Height; Body Weight; Cephalometry; D | 1992 |
Effects of prenatal administration of diazepam on the cerebral cortex of adult mice.
Topics: Animals; Cerebral Cortex; Diazepam; Female; Mice; Motor Cortex; Pregnancy; Prenatal Exposure Delayed | 1992 |
Gestational exposure to diazepam increases sensitivity to convulsants that act at the GABA/benzodiazepine receptor complex.
Topics: Animals; Bicuculline; Caffeine; Carbolines; Cerebral Cortex; Chlorides; Convulsants; Diazepam; Femal | 1991 |
Effects of prenatal administration of diazepam on the ovary of mice.
Topics: Abnormalities, Drug-Induced; Animals; Diazepam; Female; Mice; Ovary; Pregnancy; Prenatal Exposure De | 1991 |
Increase of bone calcium by prenatal exposure to diazepam in mice.
Topics: Animals; Bone and Bones; Calcium; Diazepam; Female; Fetus; Mice; Pregnancy; Prenatal Exposure Delaye | 1991 |
Effects of prenatal exposure to diazepam on exploration behavior and learning retention in mice.
Topics: Administration, Oral; Animals; Diazepam; Female; Learning; Male; Mice; Motor Activity; Pregnancy; Pr | 1991 |
Impact of prenatal low-dose diazepam or chlorpromazine on reflex and motor development and inhibitory-learning.
Topics: Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Body Weight; Chlorpromazine; Condit | 1991 |
EEG characteristics after prenatal application of diazepam in rats.
Topics: Animals; Avoidance Learning; Diazepam; Electroencephalography; Female; Learning; Memory; Pregnancy; | 1991 |
Sexually dimorphic influence of prenatal exposure to diazepam on behavioral responses to environmental challenge and on gamma-aminobutyric acid (GABA)-stimulated chloride uptake in the brain.
Topics: Animals; Behavior, Animal; Benzodiazepines; Brain; Cerebral Cortex; Chloride Channels; Chlorides; Di | 1991 |
Prenatal benzodiazepine immunosuppression: possible involvement of peripheral benzodiazepine site.
Topics: Animals; Autoradiography; Benzodiazepinones; Binding Sites; Cell Division; Clonazepam; Convulsants; | 1990 |
Physical and behavioral development in rats after late prenatal exposure to diazepam.
Topics: Amphetamine; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Body Temperature; Body | 1990 |
Effects of drug administration in pregnancy on children's school behaviour.
Topics: Antipsychotic Agents; Child; Child Behavior; Czechoslovakia; Diazepam; Drug Prescriptions; Female; H | 1990 |
Early developmental exposure to benzodiazepine ligands alters brain 31P-NMR spectra in young adult rats.
Topics: Animals; Brain; Diazepam; Female; Flumazenil; Hydrogen-Ion Concentration; Magnetic Resonance Spectro | 1990 |
Regionally specific alterations in the low-affinity GABAA receptor following perinatal exposure to diazepam.
Topics: Animals; Bicuculline; Binding, Competitive; Brain; Diazepam; Female; gamma-Aminobutyric Acid; Pregna | 1990 |
Effects of perinatal diazepam administration on two sexually dimorphic nonreproductive behaviors.
Topics: Animals; Behavior, Animal; Diazepam; Discrimination Learning; Female; Fetus; Male; Pregnancy; Prenat | 1990 |
Behavioural changes in the offspring of rats exposed to diazepam during gestation.
Topics: Animals; Animals, Newborn; Behavior, Animal; Diazepam; Ejaculation; Female; Male; Motor Activity; Pr | 1990 |
Perinatal diazepam exposure: alterations in exploratory behavior and mesolimbic dopamine turnover.
Topics: Aging; Animals; Brain; Diazepam; Dopamine; Exploratory Behavior; Female; Male; Pregnancy; Prenatal E | 1990 |
The ontogeny of benzodiazepine receptors in selected regions of the rat brain: effect of perinatal exposure to diazepam.
Topics: Animals; Brain; Brain Chemistry; Diazepam; Female; Flunitrazepam; Nerve Tissue Proteins; Pregnancy; | 1989 |
Early developmental exposure to benzodiazepine ligands alters brain levels of thiobarbituric acid-reactive products in young adult rats.
Topics: Animals; Benzodiazepines; Brain; Clonazepam; Diazepam; Female; Flumazenil; Gestational Age; Pregnanc | 1989 |
The effects of perinatal diazepam exposure on stress-induced activation of the mesotelencephalic dopamine system.
Topics: Animals; Diazepam; Dopamine; Electroshock; Female; Male; Pregnancy; Prenatal Exposure Delayed Effect | 1989 |
[Effects of prenatal exposure to alcohol on the binding of H3-diazepam to the synaptic membranes of the cerebral hemisphere cortex at various stages of ontogenesis in the rat offspring].
Topics: Age Factors; Animals; Cerebral Cortex; Diazepam; Ethanol; Female; Fetal Alcohol Spectrum Disorders; | 1988 |
The ontogeny of GABA receptors and glutamic acid decarboxylase in regions of the rat brain. Effect of prenatal exposure to diazepam.
Topics: Animals; Brain; Diazepam; Female; Glutamate Decarboxylase; Muscimol; Pregnancy; Prenatal Exposure De | 1988 |
Prenatal diazepam exposure affects beta-adrenergic receptors in brain regions of adult rat offspring.
Topics: Animals; Brain; Cerebellum; Corpus Striatum; Diazepam; Dihydroalprenolol; Female; Frontal Lobe; Hypo | 1988 |
Animal models of chronic anxiety and "fearlessness".
Topics: Animals; Anxiety; Brain; Cats; Diazepam; Disease Models, Animal; Fear; Female; Flumazenil; Flunitraz | 1988 |
Operant behavior and reactivity to the anticonflict effect of diazepam in perinatally undernourished rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Conflict, Psychological; Diazepam; Female; gamma-A | 1988 |
Some long-lasting neurochemical effects of prenatal or early postnatal exposure to diazepam.
Topics: Aging; Animals; Brain; Choline; Diazepam; Female; Frontal Lobe; gamma-Aminobutyric Acid; Hippocampus | 1985 |
[Effect of the combined prenatal use of benzodiazepine preparations and alcohol on the functions of the hypophyseal-thyroid system in newborn rat pups].
Topics: Animals; Animals, Newborn; Anti-Anxiety Agents; Diazepam; Ethanol; Female; Male; Medazepam; Pituitar | 1988 |
[Changes in the reproductive potentials of rat progeny treated during pregnancy with alcohol, diazepam, medazepam and their combinations].
Topics: Alcoholism; Animals; Anti-Anxiety Agents; Diazepam; Drug Interactions; Ethanol; Female; Male; Medaze | 1988 |
Prenatal exposure to diazepam results in enduring reductions in brain receptors and deep slow wave sleep.
Topics: Animals; Brain Chemistry; Cerebellum; Cortical Synchronization; Diazepam; Electroencephalography; Fe | 1985 |
Developmental alterations in maturing rats caused by chronic prenatal and postnatal diazepam treatments.
Topics: Acoustic Stimulation; Aging; Animals; Behavior, Animal; Cerebral Cortex; Diazepam; Female; Male; Pre | 1986 |
Release of [3H]norepinephrine: alteration by early developmental exposure to diazepam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Female; Hypothalamus; Norepinephrine; Phentolam | 1986 |
Enduring effects of prenatal diazepam on the behavior, EEG, and brain receptors of the adult cat progeny.
Topics: Agonistic Behavior; Animals; Behavior, Animal; Brain Chemistry; Cats; Conditioning, Operant; Diazepa | 1986 |
Diazepam induced long term delay in the migration of external granular layer of the cerebellum: an experimental study in the mouse.
Topics: Animals; Cell Movement; Cerebellum; Diazepam; Female; Maternal-Fetal Exchange; Mice; Mice, Inbred St | 1988 |
Differential vulnerability of male and female rats to the timing of various perinatal insults.
Topics: Animals; Behavior, Animal; Brain; Diazepam; Discrimination Learning; Female; Hypoxia; Male; Pregnanc | 1985 |