diazepam has been researched along with Congenital Stiff-Man Syndrome in 46 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a patient with severe nodulocystic acne who developed disabling muscle stiffness and painful superimposed spasms of the neck, back and upper limbs 10 days after the onset of oral isotretinoin treatment." | 9.10 | Stiff-person syndrome associated with oral isotretinoin treatment. ( Chroni, E; Georgiou, S; Monastirli, A; Paschalis, C; Pasmatzi, E; Sakkis, T; Tsambaos, D, 2002) |
| "We describe a patient with severe nodulocystic acne who developed disabling muscle stiffness and painful superimposed spasms of the neck, back and upper limbs 10 days after the onset of oral isotretinoin treatment." | 5.10 | Stiff-person syndrome associated with oral isotretinoin treatment. ( Chroni, E; Georgiou, S; Monastirli, A; Paschalis, C; Pasmatzi, E; Sakkis, T; Tsambaos, D, 2002) |
| "A 49-year-old male with type 1 diabetes presented with a 6-month history of muscle rigidity and spasms of his upper and lower extremities." | 2.46 | Stiff-person syndrome: a case report and review of the literature. ( Chedebeau, F; Egwuonwu, S, 2010) |
| "This is the youngest case of sporadic Stiffman syndrome reported in literature." | 2.40 | Sporadic Stiffman syndrome in a young girl. ( Dharnidharka, VR; Gajendragadkar, AR; Udani, SV; Udani, VP, 1997) |
| "Onset at age 76, association with insomnia and a rapid course leading to death within 2 years were the characteristic features." | 2.38 | [Stiff-Man syndrome with late onset]. ( Catanzariti, JF; Hurtevent, JF; Pasquier, F; Petit, H; Vermersch, P, 1992) |
| " Benzodiazepines are the first line drugs, but long-term use is not well characterized." | 1.42 | A Case of Stiff Person Syndrome: Immunomodulatory Effect of Benzodiazepines: Successful Rituximab and Tizanidine Therapy. ( Zdziarski, P, 2015) |
| "It is characterized by muscle spasms triggered by startle, voluntary movement, or tactile or emotional stimuli, occurring predominantly in the axial musculature." | 1.37 | Stiff person syndrome and pregnancy. ( Blaskiewicz, R; Goldkamp, J; Myles, T, 2011) |
| "Treatment with diazepam led to resolution of spasticity, whereas repeated courses of intravenous immunoglobulin improved cerebellar function, including appendicular ataxia and downbeating nystagmus." | 1.33 | Downbeating nystagmus and muscle spasms in a patient with glutamic-acid decarboxylase antibodies. ( Ances, BM; Dalmau, JO; Galetta, SL; Hasbani, MJ; Tsai, J, 2005) |
| "Diazepam is the treatment of reference." | 1.31 | Atypical low back pain: stiff-person syndrome. ( Brissot, R; Durufle, A; Gallien, P; Petrilli, S; Robineau, S; Verin, M, 2002) |
| " There was a spectacular response to treatment with diazepam, with progressive improvement although ever increasing dosage was required." | 1.30 | [Stiff-man syndrome. Presentation of a new case]. ( Fernández-Barreiro, A; Martínez-García, FA; Meca, JE; Morales, A; Salmerón, P; Tortosa, D; Villaverde, R, 1997) |
| " For treatment, the dosage and way of administration of diazepam should be judged according to the severeness of the disease; nitrazepam and clonazepam are effective, too." | 1.28 | [Clinical analysis of 30 cases of stiff-man syndrome]. ( Chen, BJ, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (28.26) | 18.2507 |
| 2000's | 24 (52.17) | 29.6817 |
| 2010's | 9 (19.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Servais, T | 1 |
| London, F | 1 |
| Donckier, JE | 1 |
| Tomczykiewicz, K | 1 |
| Pastuszak, Z | 1 |
| Staszewski, J | 1 |
| Stepień, A | 1 |
| Ajili, F | 1 |
| McKeon, A | 1 |
| Najeh, B | 1 |
| Leila, M | 1 |
| Imen, G | 1 |
| Bassem, L | 1 |
| Salah, O | 1 |
| Zdziarski, P | 1 |
| Tohid, H | 1 |
| Misra, UK | 1 |
| Maurya, PK | 1 |
| Kalita, J | 1 |
| Gupta, RK | 1 |
| Liu, YL | 1 |
| Lo, WC | 1 |
| Tseng, CH | 1 |
| Tsai, CH | 1 |
| Yang, YW | 1 |
| Egwuonwu, S | 1 |
| Chedebeau, F | 1 |
| Goldkamp, J | 1 |
| Blaskiewicz, R | 1 |
| Myles, T | 1 |
| Amyradakis, G | 1 |
| Carlan, SJ | 1 |
| Bhullar, A | 1 |
| Eastwood, J | 1 |
| Sakai, K | 3 |
| Chroni, E | 1 |
| Sakkis, T | 1 |
| Georgiou, S | 1 |
| Monastirli, A | 1 |
| Pasmatzi, E | 1 |
| Paschalis, C | 1 |
| Tsambaos, D | 1 |
| Piovano, C | 1 |
| Piattelli, M | 1 |
| Spina, T | 1 |
| Iervese, G | 1 |
| Bosco, G | 1 |
| Vogels, RL | 1 |
| van Orshoven, NP | 1 |
| de Koning-Tijssen, MA | 1 |
| Wouda, EJ | 1 |
| Weatherby, SJM | 1 |
| Woolner, P | 1 |
| Clarke, CE | 1 |
| Ergün, I | 1 |
| Akbostanci, MC | 1 |
| Canbakan, B | 1 |
| Koçer, B | 1 |
| Ensari, A | 1 |
| Nergizoglu, G | 1 |
| Keven, K | 1 |
| Ances, BM | 1 |
| Dalmau, JO | 1 |
| Tsai, J | 1 |
| Hasbani, MJ | 1 |
| Galetta, SL | 1 |
| Ferrandis, R | 1 |
| Belda, J | 1 |
| Llau, JV | 1 |
| Belda, C | 1 |
| Bahamonde, JA | 1 |
| Rakocevic, G | 1 |
| Raju, R | 1 |
| Semino-Mora, C | 1 |
| Dalakas, MC | 2 |
| Guardado Santervás, PL | 1 |
| Arjona Padillo, A | 1 |
| Serrano Castro, P | 1 |
| Olivares Romero, J | 1 |
| Rubí Callejón, J | 1 |
| Alonso Verdegay, G | 1 |
| Huete Hurtado, A | 1 |
| Holmøy, T | 1 |
| Horn, MA | 1 |
| Vandvik, B | 1 |
| Ohara, K | 1 |
| Osawa, M | 1 |
| Takeuchi, M | 1 |
| Suzuki, M | 1 |
| Uchiyama, S | 1 |
| Iwata, M | 1 |
| Mihajlovic-Madzarevic, V | 1 |
| Pappas, P | 1 |
| Hattan, E | 1 |
| Angle, MR | 1 |
| Chalk, C | 1 |
| Vernino, S | 1 |
| McEvoy, K | 1 |
| Kuhn, WF | 1 |
| Light, PJ | 1 |
| Kuhn, SC | 1 |
| Chang, YJ | 1 |
| Wu, CL | 1 |
| Lu, CS | 1 |
| Fernández-Barreiro, A | 1 |
| Villaverde, R | 1 |
| Salmerón, P | 1 |
| Morales, A | 1 |
| Martínez-García, FA | 1 |
| Meca, JE | 1 |
| Tortosa, D | 1 |
| Udani, VP | 1 |
| Dharnidharka, VR | 1 |
| Gajendragadkar, AR | 1 |
| Udani, SV | 1 |
| Sevrin, C | 1 |
| Moulin, T | 1 |
| Tatu, L | 1 |
| Monnier, G | 1 |
| Rumbach, L | 1 |
| Sevrin, P | 1 |
| Pagarkar, W | 1 |
| Khopkar, S | 1 |
| Agrawal, M | 1 |
| Levy, LM | 1 |
| Floeter, MK | 1 |
| Harada, H | 1 |
| Hayashi, A | 1 |
| Watanabe, M | 1 |
| Tamaoka, A | 1 |
| Shoji, S | 1 |
| Nikhilesh, J | 1 |
| Sayeed, ZA | 2 |
| Saravanan, PK | 2 |
| Paul, J | 2 |
| Markandeyulu, V | 1 |
| Joseph, TP | 1 |
| Solomon, T | 1 |
| Jacob, J | 1 |
| Kumar, S | 1 |
| Gnanamuthu, C | 1 |
| Gallien, P | 1 |
| Durufle, A | 1 |
| Petrilli, S | 1 |
| Verin, M | 1 |
| Brissot, R | 1 |
| Robineau, S | 1 |
| Gouider-Khouja, N | 1 |
| Mekaouar, A | 1 |
| Larnaout, A | 1 |
| Miladi, N | 1 |
| Ben Khelifa, F | 1 |
| Hentati, F | 1 |
| Calvet, D | 1 |
| Touzé, E | 1 |
| Delegue, P | 1 |
| Bertherat, J | 1 |
| Zuber, M | 1 |
| Chen, BJ | 1 |
| Vermersch, P | 1 |
| Hurtevent, JF | 1 |
| Pasquier, F | 1 |
| Catanzariti, JF | 1 |
| Petit, H | 1 |
| Bhutani, MS | 2 |
| Mathews, T | 1 |
| Akuthota, P | 1 |
| Clifton, ER | 1 |
| Subramony, SH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Rituximab in Patients With Stiff Person Syndrome With Anti-GAD Antibodies: A Randomized Placebo-Controlled Trial[NCT00091897] | Phase 2 | 24 participants (Actual) | Interventional | 2004-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for diazepam and Congenital Stiff-Man Syndrome
| Article | Year |
|---|---|
Anti-glutamic acid decarboxylase antibody positive neurological syndromes.
Topics: Autoantibodies; Baclofen; Cerebellar Ataxia; Diazepam; Epilepsy; GABA Modulators; GABA-B Receptor Ag | 2016 |
Stiff-person syndrome: a case report and review of the literature.
Topics: Anemia, Pernicious; Anti-Anxiety Agents; Baclofen; Diabetes Mellitus, Type 1; Diagnosis, Differentia | 2010 |
[Stiff-person syndrome].
Topics: Animals; Autoantibodies; Autoimmunity; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; | 2002 |
[Stiff-Man syndrome].
Topics: Animals; Autoantibodies; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; GABA Modulato | 2006 |
Sporadic Stiffman syndrome in a young girl.
Topics: Baclofen; Diagnosis, Differential; Diazepam; Drug Therapy, Combination; Female; GABA Agonists; GABA | 1997 |
The stiff-person syndrome: an autoimmune disorder affecting neurotransmission of gamma-aminobutyric acid.
Topics: Adjuvants, Immunologic; Autoantibodies; Brain; Diazepam; Electromyography; GABA Modulators; gamma-Am | 1999 |
[Stiff-man syndrome].
Topics: Autoantibodies; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; GABA Agents; gamma-Ami | 2000 |
[Stiff-Man syndrome with late onset].
Topics: Aged; Diazepam; Electromyography; Female; GABA Antagonists; Humans; Polysomnography; Sleep Initiatio | 1992 |
1 trial available for diazepam and Congenital Stiff-Man Syndrome
| Article | Year |
|---|---|
Stiff-person syndrome associated with oral isotretinoin treatment.
Topics: Acne Vulgaris; Adolescent; Dermatologic Agents; Diazepam; Electromyography; Follow-Up Studies; GABA | 2002 |
37 other studies available for diazepam and Congenital Stiff-Man Syndrome
| Article | Year |
|---|---|
Graves' disease as a first autoimmune manifestation of a stiff person syndrome.
Topics: Diabetes Mellitus, Type 1; Diazepam; Female; Graves Disease; Humans; Immunoglobulins, Intravenous; M | 2019 |
[Stiff person syndrome--case report].
Topics: Autoantibodies; Diabetes Mellitus, Type 1; Diazepam; Glutamate Decarboxylase; Humans; Male; Middle A | 2014 |
[A low back pain revealing a stiff-man syndrome].
Topics: Azathioprine; Diagnosis, Differential; Diazepam; Humans; Low Back Pain; Male; Middle Aged; Stiff-Per | 2013 |
A Case of Stiff Person Syndrome: Immunomodulatory Effect of Benzodiazepines: Successful Rituximab and Tizanidine Therapy.
Topics: Adult; Antibodies, Monoclonal, Murine-Derived; Benzodiazepines; Clonidine; Diazepam; Drug Therapy, C | 2015 |
Stiff limb syndrome: end of spectrum or a separate entity?
Topics: Adult; Diazepam; Hiccup; Humans; Lower Extremity; Male; Muscle Relaxants, Central; Seasons; Stiff-Pe | 2009 |
Reversible stiff person syndrome presenting as an initial symptom in a patient with colon adenocarcinoma.
Topics: Adenocarcinoma; Aged, 80 and over; Colonic Neoplasms; Diazepam; Female; Humans; Muscle Relaxants, Ce | 2010 |
Stiff person syndrome and pregnancy.
Topics: Adult; Amines; Baclofen; Cesarean Section; Cyclohexanecarboxylic Acids; Diazepam; Female; Gabapentin | 2011 |
Pregnancy and stiff person syndrome.
Topics: Adult; Cesarean Section; Diazepam; Female; Humans; Muscle Relaxants, Central; Pregnancy; Pregnancy C | 2012 |
The stiff-person syndrome. Case report.
Topics: Aged; Aged, 80 and over; Diazepam; Female; Glutamate Decarboxylase; Humans; Muscle Relaxants, Centra | 2002 |
['Stiff-person'-syndrome].
Topics: Adrenal Cortex Hormones; Autoantibodies; Baclofen; Diazepam; Electromyography; Female; Glutamate Dec | 2003 |
Pregnancy in stiff-limb syndrome.
Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Baclofen; Diazepam; Drug Therapy, Combination; Ext | 2004 |
Minimal change nephrotic syndrome with stiff-person syndrome: is there a link?
Topics: Adult; Cyclophosphamide; Diazepam; Drug Therapy, Combination; Electromyography; Humans; Immunity, Ce | 2005 |
Downbeating nystagmus and muscle spasms in a patient with glutamic-acid decarboxylase antibodies.
Topics: Autoantibodies; Diazepam; Diplopia; Drug Therapy, Combination; Female; Glutamate Decarboxylase; Huma | 2005 |
Anesthesia for cardiac surgery on a patient with stiff person syndrome.
Topics: Adult; Analgesics, Opioid; Anesthesia; Anesthetics, Intravenous; Anticonvulsants; Cardiopulmonary By | 2005 |
Stiff person syndrome with cerebellar disease and high-titer anti-GAD antibodies.
Topics: Adult; Aged; Anticonvulsants; Autoantibodies; Cerebellar Diseases; Diazepam; Female; Glutamate Decar | 2006 |
Stiff person syndrome (SPS), a basal ganglia disease? Striatal MRI lesions in a patient with SPS.
Topics: Aged; Basal Ganglia Diseases; Diazepam; Female; Humans; Immunoglobulins, Intravenous; Immunologic Fa | 2007 |
[A stiff-legged man with a bizarre gait].
Topics: Adult; Diazepam; Gait; Humans; Male; Muscle Relaxants, Central; Stiff-Person Syndrome | 2007 |
[Stiff-person syndrome with elevated anti-Epstein-Barr virus antibody].
Topics: Antibodies, Viral; Anticonvulsants; Diazepam; Electromyography; Epstein-Barr Virus Infections; Herpe | 2007 |
Treatment of refractory seizures due to a benign mass present in the corpus callosum with an ion magnetic inductor: case report.
Topics: Adult; Agenesis of Corpus Callosum; Anticonvulsants; Colchicine; Combined Modality Therapy; Corpus C | 2005 |
Unexpected benefit of propofol in stiff-person syndrome.
Topics: Aged; Autoantibodies; Baclofen; Diazepam; Drug Resistance; Female; GABA Agonists; GABA-A Receptor Ag | 2008 |
Propofol for stiff-person syndrome: learning new tricks from an old dog.
Topics: Aged; Autoantibodies; Baclofen; Diazepam; Drug Resistance; Female; GABA Agonists; GABA-A Receptor Ag | 2008 |
Stiff-man syndrome: case report.
Topics: Adult; Diagnosis, Differential; Diazepam; Female; GABA Modulators; Humans; Low Back Pain; Muscle Rel | 1995 |
Stiff-man syndrome: report of a case.
Topics: Adult; Diazepam; Electromyography; Humans; Male; Muscle Relaxants, Central; Stiff-Person Syndrome | 1995 |
[Stiff-man syndrome. Presentation of a new case].
Topics: Anticonvulsants; Autoimmunity; Brain; Contracture; Diabetes Mellitus, Type 1; Diazepam; Dose-Respons | 1997 |
["Stiff-man" syndrome treated with intravenous immunoglobulins].
Topics: Diazepam; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Muscle Contraction; Stiff-Person | 1998 |
Stiffman syndrome.
Topics: Child; Diagnosis, Differential; Diazepam; Electromyography; Humans; Male; Muscle Relaxants, Central; | 1998 |
[A case of stiff-man syndrome with head retraction like reflex myoclonus and jerky myoclonus of bilateral lower extremities which responded well to removal of mediastinal carcinoma].
Topics: Autoimmunity; Carcinoma; Diazepam; Head; Humans; Male; Mediastinal Neoplasms; Middle Aged; Myoclonus | 1999 |
Stiff person syndrome.
Topics: Adult; Autoantibodies; Diazepam; Electromyography; Electrophysiology; Female; Glutamate Decarboxylas | 2001 |
Stiff-man syndrome in childhood.
Topics: Child; Diazepam; Electromyography; Humans; Male; Muscle Relaxants, Central; Stiff-Person Syndrome | 2001 |
Stiff person syndrome and myasthenia gravis.
Topics: Adult; Diazepam; Electrophysiology; Female; Humans; Muscle Relaxants, Central; Myasthenia Gravis; Ne | 2002 |
Atypical low back pain: stiff-person syndrome.
Topics: Administration, Oral; Adult; Diazepam; Electromyography; Exercise Therapy; Female; Humans; Lordosis; | 2002 |
Progressive encephalomyelitis with rigidity presenting as a stiff-person syndrome.
Topics: Anti-Inflammatory Agents; Baclofen; Diagnosis, Differential; Diazepam; Drug Therapy, Combination; El | 2002 |
[Stiff limb syndrome associated with Hashimoto's encephalopathy: improvement after corticotherapy].
Topics: Aged; Antibody Specificity; Anticonvulsants; Antithyroid Agents; Autoantibodies; Autoimmune Diseases | 2002 |
[Clinical analysis of 30 cases of stiff-man syndrome].
Topics: Adolescent; Adult; Clonazepam; Diazepam; Female; Humans; Male; Middle Aged; Nitrazepam; Reference St | 1992 |
Muscle spasms and stiffness that progressed for four years.
Topics: Administration, Oral; Adult; Autoantibodies; Diagnosis, Differential; Diazepam; Electroencephalograp | 1992 |
Stiff-man syndrome.
Topics: Adult; Baclofen; Diazepam; Female; Humans; Male; Middle Aged; Stiff-Person Syndrome | 1992 |
Dysphagia in stiff-man syndrome.
Topics: Adult; Deglutition Disorders; Diazepam; Humans; Male; Stiff-Person Syndrome | 1991 |