diazepam has been researched along with Cognitive Decline in 9 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 8.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " The present study has been designed to evaluate the neuroprotective effect of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice." | 8.02 | Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations. ( Alfuraih, BS; Alsuhaibani, NA; Elsayed, AM; Mahmoud, RH; Nadwa, EH; Rashed, LA; Said, ES, 2021) |
| "In the present study, we examined the effects of nicotine on cognitive impairment, anxiety-like behavior, and hippocampal cell proliferation in rats treated with a combination of doxorubicin and cyclophosphamide." | 7.85 | Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats. ( Asanuma, M; Kanemoto, E; Kanzaki, H; Kitamura, Y; Machida, A; Miyazaki, I; Naito, N; Nakamura, Y; Sendo, T; Sugimoto, M, 2017) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 4.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " The present study has been designed to evaluate the neuroprotective effect of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice." | 4.02 | Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations. ( Alfuraih, BS; Alsuhaibani, NA; Elsayed, AM; Mahmoud, RH; Nadwa, EH; Rashed, LA; Said, ES, 2021) |
| "In the present study, we examined the effects of nicotine on cognitive impairment, anxiety-like behavior, and hippocampal cell proliferation in rats treated with a combination of doxorubicin and cyclophosphamide." | 3.85 | Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats. ( Asanuma, M; Kanemoto, E; Kanzaki, H; Kitamura, Y; Machida, A; Miyazaki, I; Naito, N; Nakamura, Y; Sendo, T; Sugimoto, M, 2017) |
| "Several observational studies have found a link between the long-term use of benzodiazepines and dementia, which remains controversial." | 1.62 | Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach. ( Bordet, R; Carton, L; Deguil, J; Kyheng, M; Laloux, C; Lenski, M; Niot, C; Petrault, M; Potey, C, 2021) |
| "A 69-year-old man with alcohol dependence and mild cognitive impairment (MCI) suffered from repeated tonic-clonic seizures." | 1.39 | Repeated seizures in an elderly patient with alcohol dependence and mild cognitive impairment. ( Araki, Y; Hatano, K; Ishii, N; Terao, T, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 4 (44.44) | 2.80 |
| Authors | Studies |
|---|---|
| Xu, YX | 1 |
| Wang, H | 1 |
| Li, XK | 1 |
| Dong, SN | 1 |
| Liu, WW | 1 |
| Gong, Q | 1 |
| Wang, TD | 1 |
| Tang, Y | 2 |
| Zhu, J | 1 |
| Li, J | 1 |
| Zhang, HY | 1 |
| Mao, F | 1 |
| Said, ES | 1 |
| Elsayed, AM | 1 |
| Rashed, LA | 1 |
| Nadwa, EH | 1 |
| Alsuhaibani, NA | 1 |
| Alfuraih, BS | 1 |
| Mahmoud, RH | 1 |
| Carton, L | 1 |
| Niot, C | 1 |
| Kyheng, M | 1 |
| Petrault, M | 1 |
| Laloux, C | 1 |
| Potey, C | 1 |
| Lenski, M | 1 |
| Bordet, R | 1 |
| Deguil, J | 1 |
| Danis, A | 1 |
| Baranoglu Kilinc, Y | 1 |
| Torun, IE | 1 |
| Hanci, F | 1 |
| Kilinc, E | 1 |
| Ankarali, H | 1 |
| Yang, Y | 1 |
| Zhang, S | 1 |
| Duan, J | 1 |
| Zhang, X | 1 |
| Tan, T | 1 |
| Wang, W | 1 |
| Williams, J | 1 |
| Ma, K | 1 |
| Cao, Q | 1 |
| Yan, Z | 1 |
| Venkatesh, G | 1 |
| Sankar, V | 1 |
| Ramanathan, M | 1 |
| Ishii, N | 1 |
| Terao, T | 1 |
| Araki, Y | 1 |
| Hatano, K | 1 |
| Kitamura, Y | 1 |
| Kanemoto, E | 1 |
| Sugimoto, M | 1 |
| Machida, A | 1 |
| Nakamura, Y | 1 |
| Naito, N | 1 |
| Kanzaki, H | 1 |
| Miyazaki, I | 1 |
| Asanuma, M | 1 |
| Sendo, T | 1 |
9 other studies available for diazepam and Cognitive Decline
| Article | Year |
|---|---|
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; | 2018 |
Evaluation of nootropic activity of telmisartan and metformin on diazepam-induced cognitive dysfunction in mice through AMPK pathway and amelioration of hippocampal morphological alterations.
Topics: AMP-Activated Protein Kinases; Animals; Behavior, Animal; Caspase 3; Cell Death; Cognitive Dysfuncti | 2021 |
Lack of direct involvement of a diazepam long-term treatment in the occurrence of irreversible cognitive impairment: a pre-clinical approach.
Topics: Animals; Cognition; Cognitive Dysfunction; Diazepam; Humans; Male; Maze Learning; Memory, Short-Term | 2021 |
Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Cytokines; Diazepam; Disease Models, Animal; Epilep | 2023 |
Acute visual impairment as a main presenting symptom of non-convulsive status epilepticus: a case report.
Topics: Anticonvulsants; Cognitive Dysfunction; Dementia, Vascular; Diazepam; Diffusion Magnetic Resonance I | 2020 |
Stress Exposure in Dopamine D4 Receptor Knockout Mice Induces Schizophrenia-Like Behaviors via Disruption of GABAergic Transmission.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Diazepam; Exploratory Behavior; Female; GABA Modul | 2019 |
Molecular mechanism of tuberoinfundibular peptide of 39 on glucocorticoid receptor mediated glutamate/GABA imbalance and cerebral abnormalities against cognitive deficit model.
Topics: Animals; Cognitive Dysfunction; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; | 2019 |
Repeated seizures in an elderly patient with alcohol dependence and mild cognitive impairment.
Topics: Aged; Alcohol Withdrawal Seizures; Alcoholism; Cognitive Dysfunction; Diazepam; Humans; Male; Valpro | 2013 |
Influence of nicotine on doxorubicin and cyclophosphamide combination treatment-induced spatial cognitive impairment and anxiety-like behavior in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Antineoplastic Agents; Anxiety; Behavior, Animal; | 2017 |