diazepam has been researched along with Cognition Disorders in 37 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study investigated the possible relation between muscimol-induced long-term depression and barbiturates/benzodiazepine-induced amnesia and attempts to determine the possible effect of pregnenolone sulfate on muscimol-induced long-term depression." | 7.70 | Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate. ( Akhondzadeh, S; Stone, TW, 1998) |
| "Diazepam-resistant SE was induced in adult mice fed with standard or ketogenic diet or in cannabinoid receptor type 1 (CB1) receptor knock-out mice." | 5.48 | Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. ( Butler, CR; Guilmette, E; Pauletti, A; Piro, JR; Porcu, L; Rizzi, M; Salamone, A; Samad, TA; Sheehan, MJ; Terrone, G; Vezzani, A; Villa, BR, 2018) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 5.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| " The present study investigated the possible relation between muscimol-induced long-term depression and barbiturates/benzodiazepine-induced amnesia and attempts to determine the possible effect of pregnenolone sulfate on muscimol-induced long-term depression." | 3.70 | Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate. ( Akhondzadeh, S; Stone, TW, 1998) |
| "Diazepam-resistant SE was induced in adult mice fed with standard or ketogenic diet or in cannabinoid receptor type 1 (CB1) receptor knock-out mice." | 1.48 | Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. ( Butler, CR; Guilmette, E; Pauletti, A; Piro, JR; Porcu, L; Rizzi, M; Salamone, A; Samad, TA; Sheehan, MJ; Terrone, G; Vezzani, A; Villa, BR, 2018) |
| " Moreover, chronic administration of EA at dose 30 mg/kg ameliorated the memory deficit induced by diazepam (1 mg/kg, i." | 1.43 | Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments. ( Farbood, Y; Mansouri, MT; Mirshekar, MA; Naghizadeh, B; Sarkaki, A; Shabani, S, 2016) |
| "The pilocarpine model of TLE has been widely used to study characteristics of human TLE, including behavioral comorbidities." | 1.42 | Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice. ( Fighera, MR; Funck, VR; Furian, AF; Grigoletto, J; Oliveira, CV; Oliveira, MS; Ribeiro, LR; Royes, LF, 2015) |
| "Epilepsy affects 0." | 1.37 | Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. ( Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G, 2011) |
| "Rats treated with isoflurane had the best cognitive recovery (p < 0." | 1.33 | Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. ( Alexander, H; Clark, RS; Dixon, CE; Jenkins, L; Kochanek, PM; Statler, KD; Vagni, V, 2006) |
| "Non-convulsive status epilepticus is characterized by confusion and impaired consciousness, lasting at least half an hour." | 1.31 | [Non-convulsive status epilepticus--confusion and cognitive failure during seizures]. ( Engelsen, B; Karlsen, B; Lillebø, A, 2000) |
| " The results have implications for evaluating the safety of the long-term use of BZ medications." | 1.27 | Chronic use of benzodiazepines and psychomotor and cognitive test performance. ( Geller, AM; Lucki, I; Rickels, K, 1986) |
| "A 55 year old man developed an acute confusional state with grossly impaired short-term memory accompanied by a Status Petit Mal epilepsy pattern on EEG, one to two weeks after abruptly discontinuing a large amount of oxazepam and a smaller amount of alcohol." | 1.27 | Acute confusional state with status petit mal as a withdrawal syndrome--and five year follow-up. ( Billings, RF; Hersch, EL, 1988) |
| "The ictal confusion in later life seems to be an entity, actually frequently reported in literature, which needs better description." | 1.27 | [A critical confusion state of frontal origin in elderly subjects: difficult diagnosis]. ( Papy, JJ; Rey, M, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (48.65) | 18.7374 |
| 1990's | 5 (13.51) | 18.2507 |
| 2000's | 7 (18.92) | 29.6817 |
| 2010's | 7 (18.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Terrone, G | 1 |
| Pauletti, A | 1 |
| Salamone, A | 1 |
| Rizzi, M | 1 |
| Villa, BR | 1 |
| Porcu, L | 1 |
| Sheehan, MJ | 1 |
| Guilmette, E | 1 |
| Butler, CR | 1 |
| Piro, JR | 1 |
| Samad, TA | 1 |
| Vezzani, A | 1 |
| Gogol, M | 1 |
| Hartmann, H | 1 |
| Wustmann, S | 1 |
| Simm, A | 1 |
| Deshpande, LS | 1 |
| Phillips, K | 1 |
| Huang, B | 1 |
| DeLorenzo, RJ | 1 |
| Oliveira, CV | 1 |
| Grigoletto, J | 1 |
| Funck, VR | 1 |
| Ribeiro, LR | 1 |
| Royes, LF | 1 |
| Fighera, MR | 1 |
| Furian, AF | 1 |
| Oliveira, MS | 1 |
| Mansouri, MT | 1 |
| Farbood, Y | 1 |
| Naghizadeh, B | 1 |
| Shabani, S | 1 |
| Mirshekar, MA | 1 |
| Sarkaki, A | 1 |
| Venturin, GT | 1 |
| Greggio, S | 1 |
| Marinowic, DR | 1 |
| Zanirati, G | 1 |
| Cammarota, M | 1 |
| Machado, DC | 1 |
| DaCosta, JC | 1 |
| Wilhelm, EA | 1 |
| Souza, AC | 1 |
| Gai, BM | 1 |
| Chagas, PM | 1 |
| Roehrs, JA | 1 |
| Nogueira, CW | 1 |
| Arciniegas, DB | 1 |
| Frey, KL | 1 |
| Anderson, CA | 1 |
| Brousseau, KM | 1 |
| Harris, SN | 1 |
| Nakazono, K | 1 |
| Watanabe, Y | 1 |
| Nakaya, S | 1 |
| Asami, Y | 1 |
| Masuhara, K | 1 |
| Itoh, F | 1 |
| Ogata, H | 1 |
| Statler, KD | 1 |
| Alexander, H | 1 |
| Vagni, V | 1 |
| Dixon, CE | 1 |
| Clark, RS | 1 |
| Jenkins, L | 1 |
| Kochanek, PM | 1 |
| Eizadi-Mood, N | 1 |
| Somerville, ER | 1 |
| Bruni, J | 1 |
| Brooker, AE | 1 |
| Wiens, AN | 1 |
| Wiens, DA | 1 |
| Elsass, P | 1 |
| Stibolt, O | 1 |
| Klauber, PV | 1 |
| Christensen, SE | 1 |
| Lunding, M | 1 |
| Busch, KT | 1 |
| Schulz, H | 1 |
| Brioni, JD | 1 |
| O'Neill, AB | 1 |
| Kim, DJ | 1 |
| Buckley, MJ | 1 |
| Decker, MW | 1 |
| Arneric, SP | 1 |
| Tata, PR | 1 |
| Rollings, J | 1 |
| Collins, M | 1 |
| Pickering, A | 1 |
| Jacobson, RR | 1 |
| Longone, P | 1 |
| Impagnatiello, F | 1 |
| Guidotti, A | 1 |
| Costa, E | 1 |
| Akhondzadeh, S | 1 |
| Stone, TW | 1 |
| Rasmussen, LS | 1 |
| Steentoft, A | 1 |
| Rasmussen, H | 1 |
| Kristensen, PA | 1 |
| Moller, JT | 1 |
| Karlsen, B | 1 |
| Engelsen, B | 1 |
| Lillebø, A | 1 |
| Baglietto, MG | 1 |
| Battaglia, FM | 1 |
| Nobili, L | 1 |
| Tortorelli, S | 1 |
| De Negri, E | 1 |
| Calevo, MG | 1 |
| Veneselli, E | 1 |
| De Negri, M | 1 |
| Calvet, D | 1 |
| Touzé, E | 1 |
| Delegue, P | 1 |
| Bertherat, J | 1 |
| Zuber, M | 1 |
| Lucki, I | 1 |
| Rickels, K | 1 |
| Geller, AM | 1 |
| Weingartner, H | 1 |
| Funderburk, FR | 1 |
| Griffiths, RR | 1 |
| McLeod, DR | 1 |
| Bigelow, GE | 1 |
| Mackenzie, A | 1 |
| Liebson, IA | 1 |
| Nemeth-Coslett, R | 1 |
| Hersch, EL | 1 |
| Billings, RF | 1 |
| Rey, M | 1 |
| Papy, JJ | 1 |
| Prior, PF | 1 |
| Maclaine, GN | 1 |
| Scott, DF | 2 |
| Lawrance, BM | 1 |
| Schwartz, MS | 1 |
| Groh, CH | 1 |
| Rosenmayr, FW | 1 |
| Borenstein, P | 1 |
| Champion, C | 1 |
| Cujo, P | 1 |
| Gekière, F | 1 |
| Olivenstein, C | 1 |
| Kramarz, P | 1 |
| Feffer, HL | 1 |
| Mahomedy, YH | 1 |
| Downing, JW | 1 |
| Coleman, AJ | 1 |
| Mahomedy, MC | 1 |
| Raskin, A | 1 |
| Tudor, I | 1 |
| Cramond, WA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Amantadine for Neuroenhancement in Acute Patients Study - A Prospective Pilot Proof of Concept Phase IIb Study in Intensive and Intermediate Care Unit Patients[NCT05479032] | Phase 2 | 50 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for diazepam and Cognition Disorders
| Article | Year |
|---|---|
A clinical neuropsychological study of the postoperative course after three types of anaesthesia.
Topics: Adult; Aged; Alfaxalone Alfadolone Mixture; Anesthetics; Clinical Trials as Topic; Cognition Disorde | 1982 |
Benzodiazepines and postoperative cognitive dysfunction in the elderly. ISPOCD Group. International Study of Postoperative Cognitive Dysfunction.
Topics: Abdomen; Age Factors; Aged; Aged, 80 and over; Anesthesia, General; Anti-Anxiety Agents; Cognition D | 1999 |
Relative abuse liability of lorazepam and diazepam: an evaluation in 'recreational' drug users.
Topics: Adult; Cognition Disorders; Diazepam; Double-Blind Method; Humans; Lorazepam; Male; Psychomotor Diso | 1988 |
[An original psychotropic drug: sulpiride].
Topics: Adult; Animals; Anxiety; Behavior; Clinical Trials as Topic; Cognition Disorders; Delirium; Depressi | 1969 |
Double-blind evaluation of diazepam, sodium pentobarbital, and placebo as adjunctive premedicants prior to discography.
Topics: Adjuvants, Anesthesia; Adult; Aged; Anxiety; Blood Pressure; Clinical Trials as Topic; Cognition Dis | 1974 |
Ketamine and the obstetric patient.
Topics: Anesthesia, General; Anesthesia, Intravenous; Anesthesia, Obstetrical; Cesarean Section; Cognition; | 1974 |
31 other studies available for diazepam and Cognition Disorders
| Article | Year |
|---|---|
Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.
Topics: Animals; Brain; Brain Waves; Carbamates; Cognition Disorders; Diazepam; Disease Models, Animal; Dose | 2018 |
Influence of central nervous system-acting drugs on results of cognitive testing in geriatric inpatients.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Antidepressive Agents; Benzodiazepines; Central Nervous | 2014 |
Chronic behavioral and cognitive deficits in a rat survival model of paraoxon toxicity.
Topics: Anhedonia; Animals; Anxiety; Atropine; Behavior, Animal; Cognition Disorders; Depression; Diazepam; | 2014 |
Evaluation of potential gender-related differences in behavioral and cognitive alterations following pilocarpine-induced status epilepticus in C57BL/6 mice.
Topics: Age Factors; Analysis of Variance; Animals; Anticonvulsants; Cognition Disorders; Diazepam; Disease | 2015 |
Beneficial effects of ellagic acid against animal models of scopolamine- and diazepam-induced cognitive impairments.
Topics: Amnesia; Animals; Avoidance Learning; Behavior, Animal; Cognition; Cognition Disorders; Diazepam; Di | 2016 |
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Di | 2011 |
Hyperthermic seizures enhance responsiveness to pentylenetetrazole and induce cognitive dysfunction: protective effect of 3-alkynyl selenophene.
Topics: Animals; Anticonvulsants; Cognition Disorders; Convulsants; Diazepam; Hyperthermia, Induced; Male; M | 2012 |
Amantadine for neurobehavioural deficits following delayed post-hypoxic encephalopathy.
Topics: Adult; Amantadine; Brain; Brain Injuries; Cognition Disorders; Demyelinating Diseases; Diazepam; Dop | 2004 |
Impairment state of cognitive performance and the affecting factors in outpatients following gastrointestinal endoscopy after single-dose diazepam.
Topics: Adult; Aged; Alleles; Anti-Anxiety Agents; Aryl Hydrocarbon Hydroxylases; Cognition Disorders; Cytoc | 2005 |
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
Topics: Anesthetics; Animals; Brain; Brain Injuries; Cell Survival; Cognition Disorders; Diazepam; Disease M | 2006 |
Nalidixic acid overdose and metabolic acidosis.
Topics: Acidosis; Adolescent; Anti-Infective Agents; Anticonvulsants; Cognition Disorders; Diazepam; Drug Ov | 2006 |
Tonic status epilepticus presenting as confusional state.
Topics: Adolescent; Cognition Disorders; Confusion; Diazepam; Electroencephalography; Humans; Male; Methylph | 1983 |
Impaired brain functions due to diazepam and meprobamate abuse in a 53-year-old-male.
Topics: Cognition Disorders; Diazepam; Humans; Male; Memory Disorders; Meprobamate; Middle Aged; MMPI; Motor | 1984 |
[The acute psychiatric emergency].
Topics: Acute Disease; Aged; Alcoholism; Amitriptyline; Brain Ischemia; Cognition Disorders; Consciousness D | 1981 |
Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Cognition Disorders; Diazepam; Isoxazoles; Male; | 1994 |
Lack of cognitive recovery following withdrawal from long-term benzodiazepine use.
Topics: Adult; Benzodiazepines; Cognition Disorders; Diazepam; Female; Humans; Male; Memory Disorders; Middl | 1994 |
Reversible modification of GABAA receptor subunit mRNA expression during tolerance to diazepam-induced cognition dysfunction.
Topics: Animals; Anticonvulsants; Benzodiazepines; Cognition Disorders; Diazepam; Drug Tolerance; GABA Modul | 1996 |
Potentiation of muscimol-induced long-term depression by benzodiazepines and prevention or reversal by pregnenolone sulfate.
Topics: Amnesia; Animals; Barbiturates; Benzodiazepines; Cognition Disorders; Depression; Diazepam; Drug Syn | 1998 |
[Non-convulsive status epilepticus--confusion and cognitive failure during seizures].
Topics: Adult; Aged; Anticonvulsants; Cognition Disorders; Confusion; Diazepam; Electroencephalography; Fema | 2000 |
Neuropsychological disorders related to interictal epileptic discharges during sleep in benign epilepsy of childhood with centrotemporal or Rolandic spikes.
Topics: Anticonvulsants; Attention; Case-Control Studies; Child; Cognition Disorders; Diazepam; Electroencep | 2001 |
[Stiff limb syndrome associated with Hashimoto's encephalopathy: improvement after corticotherapy].
Topics: Aged; Antibody Specificity; Anticonvulsants; Antithyroid Agents; Autoantibodies; Autoimmune Diseases | 2002 |
Chronic use of benzodiazepines and psychomotor and cognitive test performance.
Topics: Adult; Affect; Aged; Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Clorazepate Dipotassium; Cogn | 1986 |
Models of memory dysfunctions.
Topics: Adult; Aged; Alcohol Amnestic Disorder; Alzheimer Disease; Amnesia; Attention; Attention Deficit Dis | 1985 |
Acute confusional state with status petit mal as a withdrawal syndrome--and five year follow-up.
Topics: Acute Disease; Cognition Disorders; Confusion; Diazepam; Follow-Up Studies; Humans; Injections, Intr | 1988 |
[A critical confusion state of frontal origin in elderly subjects: difficult diagnosis].
Topics: Acute Disease; Aged; Aged, 80 and over; Cognition Disorders; Confusion; Diazepam; Electroencephalogr | 1987 |
Intravenous diazepam.
Topics: Child; Cognition Disorders; Diazepam; Electroencephalography; Female; Humans; Injections, Intravenou | 1971 |
Isolated petit-mal status presenting de novo in middle age.
Topics: Adult; Age Factors; Cognition Disorders; Diazepam; Electroencephalography; Epilepsy, Absence; Female | 1971 |
[Isolated petit mal status epilepticus. A new epilepsy syndrome characterised by paroxysmal behavioural disturbances (author's transl)].
Topics: Benzodiazepinones; Child; Child Behavior Disorders; Cognition Disorders; Diagnosis, Differential; Di | 1974 |
Age-sex differences in response to antidepressant drugs.
Topics: Adjustment Disorders; Adolescent; Adult; Age Factors; Aged; Antidepressive Agents; Anxiety; Chlorpro | 1974 |
Electroclinical aspects of remission of status epilepticus.
Topics: Adult; Alpha Rhythm; Automatism; Barbiturates; Cognition Disorders; Diazepam; Electroencephalography | 1970 |
Organic psychosis.
Topics: Acute Disease; Affective Symptoms; Bender-Gestalt Test; Chlordiazepoxide; Chlorpromazine; Chronic Di | 1968 |