diazepam has been researched along with Cleft Palate in 26 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Key words were diazepam or benzodiazepine(s) combined with cleft lip, cleft palate, oral malformations, prenatal exposure, GABA, gene expression and extracellular matrix." | 8.87 | Diazepam effects on non-syndromic cleft lip with or without palate: epidemiological studies, clinical findings, genes and extracellular matrix. ( Balloni, S; Bodo, M; Carinci, F; Locci, P; Marinucci, L; Pezzetti, F, 2011) |
| "To investigate the effect of Gama-OH-Diazepam combined anaesthesia for cleft palate repair in children below 3 years old." | 7.69 | [Gama hydroxybutyrate sodium (gama-OH)-diazepam combined anaesthesia for cleft palate repair in children below 3 years old]. ( Jiang, X; Meng, X, 1997) |
| "Cleft palate frequencies were studied in AJ and SW mice following either 1- or 2-day dosing schedules with the anxiolytic drug diazepam (DAZ)." | 7.67 | Diazepam-induced cleft palate in the mouse and lack of correlation with the H-2 locus. ( Renskers, K; Tocco, DR; Zimmerman, EF, 1987) |
| "The hypothesis that in utero exposure to diazepam increases the risk of oral-cleft anomalies was evaluated in a case-control study, in which 445 infants with cleft lip with or without cleft palate and 166 with cleft palate without cleft lip (cleft palate alone) were compared with 2498 control infants having other birth defects." | 7.66 | Lack of relation of oral clefts to diazepam use during pregnancy. ( Louik, C; Mitchell, AA; Parsells, JL; Pashayan, H; Rosenberg, L; Shapiro, S, 1983) |
| " The mother took clonidine during pregnancy." | 7.66 | Roberts's syndrome and clonidine. ( Beshara, D; Levy, JM; Stoll, C, 1979) |
| "From 278 interviews of women who had infants with selected major malformations, a history of diazepam ingestion in the first trimester of pregnancy was found to be four times more frequent among mothers of children with a cleft lip with or without a cleft palate than among mothers of children with other defects." | 7.65 | Association between cleft lip with or without cleft palate and prenatal exposure to diazepam. ( Oakley, GP; Safra, MJ, 1975) |
| " Key words were diazepam or benzodiazepine(s) combined with cleft lip, cleft palate, oral malformations, prenatal exposure, GABA, gene expression and extracellular matrix." | 4.87 | Diazepam effects on non-syndromic cleft lip with or without palate: epidemiological studies, clinical findings, genes and extracellular matrix. ( Balloni, S; Bodo, M; Carinci, F; Locci, P; Marinucci, L; Pezzetti, F, 2011) |
| "To investigate the effect of Gama-OH-Diazepam combined anaesthesia for cleft palate repair in children below 3 years old." | 3.69 | [Gama hydroxybutyrate sodium (gama-OH)-diazepam combined anaesthesia for cleft palate repair in children below 3 years old]. ( Jiang, X; Meng, X, 1997) |
| " Diazepam (Valium) could cause cleft palate by mimicking GABA." | 3.67 | Neuropharmacologic teratogenesis and neurotransmitter regulation of palate development. ( Zimmerman, EF, 1984) |
| " Diazepam may cause cleft palate by mimicking GABA." | 3.67 | Role of neurotransmitters and teratogens on palate development. ( Venkatasubramanian, K; Wee, EL; Zimmerman, EF, 1985) |
| "Cleft palate frequencies were studied in AJ and SW mice following either 1- or 2-day dosing schedules with the anxiolytic drug diazepam (DAZ)." | 3.67 | Diazepam-induced cleft palate in the mouse and lack of correlation with the H-2 locus. ( Renskers, K; Tocco, DR; Zimmerman, EF, 1987) |
| "The hypothesis that in utero exposure to diazepam increases the risk of oral-cleft anomalies was evaluated in a case-control study, in which 445 infants with cleft lip with or without cleft palate and 166 with cleft palate without cleft lip (cleft palate alone) were compared with 2498 control infants having other birth defects." | 3.66 | Lack of relation of oral clefts to diazepam use during pregnancy. ( Louik, C; Mitchell, AA; Parsells, JL; Pashayan, H; Rosenberg, L; Shapiro, S, 1983) |
| " The mother took clonidine during pregnancy." | 3.66 | Roberts's syndrome and clonidine. ( Beshara, D; Levy, JM; Stoll, C, 1979) |
| "From 278 interviews of women who had infants with selected major malformations, a history of diazepam ingestion in the first trimester of pregnancy was found to be four times more frequent among mothers of children with a cleft lip with or without a cleft palate than among mothers of children with other defects." | 3.65 | Association between cleft lip with or without cleft palate and prenatal exposure to diazepam. ( Oakley, GP; Safra, MJ, 1975) |
| " In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida." | 3.65 | A teratological evaluation of anticonvulsant drugs. ( Czeizel, E; Lakos, P, 1977) |
| " Dams in each dosage group were killed at 16." | 1.27 | Effect of diazepam on the embryonic development of the palate in the rat. ( Katz, RA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (88.46) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 1 (3.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marinucci, L | 2 |
| Balloni, S | 2 |
| Bodo, M | 2 |
| Carinci, F | 2 |
| Pezzetti, F | 2 |
| Stabellini, G | 1 |
| Conte, C | 1 |
| Carmela, C | 1 |
| Lumare, E | 1 |
| Locci, P | 1 |
| Zimmerman, EF | 5 |
| Wee, EL | 2 |
| Shiono, PH | 1 |
| Mills, JL | 1 |
| Rosenberg, L | 1 |
| Mitchell, AA | 1 |
| Parsells, JL | 1 |
| Pashayan, H | 1 |
| Louik, C | 1 |
| Shapiro, S | 1 |
| Shader, RI | 1 |
| Greenblatt, DJ | 1 |
| Entman, SS | 1 |
| Vaughn, WK | 1 |
| Barlow, SM | 1 |
| Knight, AF | 1 |
| Sullivan, FM | 1 |
| Jiang, X | 1 |
| Meng, X | 1 |
| Safra, MJ | 2 |
| Oakley, GP | 2 |
| Saxén, I | 2 |
| Saxén, L | 1 |
| Aarskog, D | 1 |
| Czeizel, A | 1 |
| Stoll, C | 1 |
| Levy, JM | 1 |
| Beshara, D | 1 |
| Lakos, P | 1 |
| Czeizel, E | 1 |
| Canfield, PR | 1 |
| Lunde, I | 1 |
| Brochgrevink, CF | 1 |
| Miller, RP | 1 |
| Becker, BA | 1 |
| Venkatasubramanian, K | 1 |
| Katz, RA | 1 |
| Tocco, DR | 1 |
| Renskers, K | 1 |
| Walker, BE | 1 |
| Patterson, A | 1 |
2 reviews available for diazepam and Cleft Palate
| Article | Year |
|---|---|
Diazepam effects on non-syndromic cleft lip with or without palate: epidemiological studies, clinical findings, genes and extracellular matrix.
Topics: Animals; Anti-Anxiety Agents; Cleft Lip; Cleft Palate; Diazepam; Environment; Epidemiologic Studies; | 2011 |
Role of neurotransmitters in palate development.
Topics: Animals; Catecholamines; Cleft Palate; Diazepam; gamma-Aminobutyric Acid; Mice; Morphogenesis; Neuro | 1984 |
24 other studies available for diazepam and Cleft Palate
| Article | Year |
|---|---|
Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture.
Topics: Anti-Anxiety Agents; Case-Control Studies; Cell Proliferation; Cell Shape; Cells, Cultured; Child; C | 2009 |
Neuropharmacologic teratogenesis and neurotransmitter regulation of palate development.
Topics: Abnormalities, Drug-Induced; Acetylcholine; Animals; Cell Movement; Cleft Palate; Diazepam; Dopamine | 1984 |
Oral clefts and diazepam use during pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Palate; Diazepam; Female; Fetus; Humans; Infant, Newborn; Pregnan | 1984 |
Lack of relation of oral clefts to diazepam use during pregnancy.
Topics: Cleft Lip; Cleft Palate; Diazepam; Female; Fetus; Humans; Infant; Infant, Newborn; Interviews as Top | 1983 |
Benzodiazepines during early pregnancy.
Topics: Cleft Lip; Cleft Palate; Diazepam; Humans; Risk | 1984 |
Lack of relation of oral clefts to diazepam use in pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Pre | 1984 |
Diazepam-induced cleft palate in the mouse: the role of endogenous maternal corticosterone.
Topics: Animals; Cleft Palate; Corticosterone; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; F | 1980 |
[Gama hydroxybutyrate sodium (gama-OH)-diazepam combined anaesthesia for cleft palate repair in children below 3 years old].
Topics: Anesthesia, Intravenous; Anesthetics, Intravenous; Child, Preschool; Cleft Palate; Diazepam; Female; | 1997 |
Association between cleft lip with or without cleft palate and prenatal exposure to diazepam.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Maternal-Fetal Excha | 1975 |
Letter: Association between maternal intake of diazepam and oral clefts.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant; Infant, Newb | 1975 |
Letter: Association between maternal intake of diazepam and oral clefts.
Topics: Cleft Palate; Diazepam; Female; Finland; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Trime | 1975 |
Letter: Diazepam, phenytoin, and aetiology of cleft lip and/or cleft palate.
Topics: Anencephaly; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Phenytoin; Pregnanc | 1976 |
Roberts's syndrome and clonidine.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Cleft Lip; Cleft Palate; Clonidine; Diazepam; | 1979 |
A teratological evaluation of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anencephaly; Anticonvulsants; Cleft Lip; Cleft Palate; Diazepam; Epilep | 1977 |
Teratogenic effects of drugs during pregnancy.
Topics: Abnormalities, Drug-Induced; Cleft Palate; Diazepam; Female; Genitalia, Male; Humans; Male; Pregnanc | 1978 |
Valium: an oral cleft teratogen?
Topics: Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Teratogens | 1976 |
[Use of diazepam in early pregnancy].
Topics: Abnormalities, Drug-Induced; Cleft Lip; Cleft Palate; Diazepam; Female; Humans; Infant, Newborn; Pre | 1976 |
Associations between oral clefts and drugs taken during pregnancy.
Topics: Abnormalities, Drug-Induced; Analgesics; Anticonvulsants; Chloramphenicol; Cleft Lip; Cleft Palate; | 1975 |
Teratogenicity of oral diazepam and diphenylhydantoin in mice.
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Cleft Palate; Diazepam; Female; Fetal Death; Fetu | 1975 |
Role of neurotransmitters in palate development and teratologic implications.
Topics: Abnormalities, Drug-Induced; Animals; Biological Transport, Active; Cleft Palate; Diazepam; Female; | 1985 |
Role of neurotransmitters and teratogens on palate development.
Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Cell Movement; Cleft Palate; Diazepam; g | 1985 |
Effect of diazepam on the embryonic development of the palate in the rat.
Topics: Animals; Cleft Palate; Diazepam; Dose-Response Relationship, Drug; Female; Maternal-Fetal Exchange; | 1988 |
Diazepam-induced cleft palate in the mouse and lack of correlation with the H-2 locus.
Topics: Animals; Cleft Palate; Diazepam; Female; H-2 Antigens; Haplotypes; Mice; Mice, Inbred A; Pregnancy; | 1987 |
Induction of cleft palate in mice by tranquilizers and barbiturates.
Topics: Animals; Barbiturates; Chlordiazepoxide; Chlorpromazine; Cleft Palate; Diazepam; Female; Hydroxyzine | 1974 |