diazepam has been researched along with Cirrhosis, Liver in 20 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of 5 mg of diazepam intravenously were assessed in 23 patients with liver disease, 10 of whom had clinical evidence either in the past or at the time of study of hepatic encephalopathy." | 3.65 | Clinical and electroencephalographic assessment of diazepam in liver disease. ( Knill-Jones, RP; Murray-Lyon, IM; Parkes, JD; Williams, R; Young, J, 1971) |
| " Using this dosage regime, midazolam caused significantly greater impairment in psychomotor function in both cirrhotic and non cirrhotic subjects, and the time taken for recovery of normal function was also significantly prolonged." | 2.66 | Sedation for gastroscopy: a comparative study of midazolam and Diazemuls in patients with and without cirrhosis. ( Hamdy, NA; Kennedy, HJ; Nicholl, J; Triger, DR, 1986) |
| " The accumulation of DD after multiple dosage could be explained by the fact that it is formed faster from D than it is eliminated." | 2.64 | Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease. ( Antonin, KH; Bieck, PR; Brügel, H; Klotz, U, 1977) |
| "We present a case of delirium tremens lasting for five weeks in an alcohol-dependent individual." | 1.39 | A case of prolonged delirium tremens. ( Jacob, R; Kinson, R; Nicholas, J, 2013) |
| " Plasma concentrations of DZ and its major metabolite desmethyldiazepam (DMDZ) were measured daily during the period of dosing and in the 7-day washout period that followed." | 1.27 | Repeated diazepam dosing in cirrhotic patients: cumulation and sedation. ( Eckardt, B; Greenblatt, DJ; Harmatz, JS; Ochs, HR; Shader, RI, 1983) |
| " The mean biological half-life (T/2) of diazepam was increased five-fold in patients with cirrhosis compared to the controls (164 hours vs." | 1.26 | Pharmacokinetics of diazepam in disordered liver function. ( Andreasen, PB; Greisen, G; Hendel, J; Hvidberg, EF, 1976) |
| " Despite the profound prolongation of t 1/2 (theta) with age, the constancy of diazepam clearance indicates that drug plasma concentrations will not accumulate any more in the old than the young, and chronic dosage more in the old than the young, and chronic dosage modifications based on pharmacokinetic considerations are unnecessary." | 1.25 | The effects of age and liver disease on the disposition and elimination of diazepam in adult man. ( Avant, GR; Hoyumpa, A; Klotz, U; Schenker, S; Wilkinson, GR, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (80.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nicholas, J | 1 |
| Jacob, R | 1 |
| Kinson, R | 1 |
| Nagumo, K | 1 |
| Tanaka, M | 2 |
| Chuang, VT | 1 |
| Setoyama, H | 1 |
| Watanabe, H | 1 |
| Yamada, N | 1 |
| Kubota, K | 1 |
| Matsushita, K | 1 |
| Yoshida, A | 1 |
| Jinnouchi, H | 1 |
| Anraku, M | 1 |
| Kadowaki, D | 1 |
| Ishima, Y | 1 |
| Sasaki, Y | 1 |
| Otagiri, M | 1 |
| Maruyama, T | 1 |
| Ochs, HR | 1 |
| Greenblatt, DJ | 1 |
| Eckardt, B | 1 |
| Harmatz, JS | 1 |
| Shader, RI | 1 |
| García-Morillas, M | 1 |
| Gil-Extremera, B | 1 |
| Caracuel-Ruiz, MD | 1 |
| McConnell, JB | 1 |
| Curry, SH | 1 |
| Davis, M | 1 |
| Williams, R | 2 |
| Degos, JD | 1 |
| Meyrignac, C | 1 |
| Kammerer, J | 1 |
| Houin, G | 1 |
| Jarry, GG | 1 |
| Van Roey, G | 1 |
| Lijnen, P | 1 |
| Verbesselt, R | 1 |
| Verbruggen, A | 1 |
| Fevery, J | 1 |
| Perney, P | 1 |
| Butterworth, RF | 1 |
| Mousseau, DD | 1 |
| Lavoie, J | 1 |
| Fabbro-Peray, P | 1 |
| Blanc, F | 1 |
| Layrargues, GP | 1 |
| Hoyumpa, AM | 2 |
| Schenker, S | 3 |
| Wilkinson, GR | 2 |
| Klotz, U | 2 |
| Antonin, KH | 1 |
| Brügel, H | 1 |
| Bieck, PR | 1 |
| Kober, A | 1 |
| Jenner, A | 1 |
| Sjöholm, I | 1 |
| Andreasen, PB | 1 |
| Hendel, J | 1 |
| Greisen, G | 1 |
| Hvidberg, EF | 1 |
| Avant, GR | 1 |
| Hoyumpa, A | 1 |
| Pacifici, GM | 1 |
| Viani, A | 1 |
| Rizzo, G | 1 |
| Carrai, M | 1 |
| Hamdy, NA | 1 |
| Kennedy, HJ | 1 |
| Nicholl, J | 1 |
| Triger, DR | 1 |
| Trennery, PN | 1 |
| Waring, RH | 1 |
| Hamm, DD | 1 |
| Papp, JP | 1 |
| Murray-Lyon, IM | 1 |
| Young, J | 1 |
| Parkes, JD | 1 |
| Knill-Jones, RP | 1 |
1 review available for diazepam and Cirrhosis, Liver
| Article | Year |
|---|---|
The effect of parenchymal liver disease on the disposition and elimination of sedatives and analgesics.
Topics: Analgesics; Anti-Anxiety Agents; Barbiturates; Diazepam; Half-Life; Hepatitis; Humans; Hypnotics and | 1975 |
2 trials available for diazepam and Cirrhosis, Liver
| Article | Year |
|---|---|
Disposition of diazepam and its major metabolite desmethyldiazepam in patients with liver disease.
Topics: Adult; Biological Availability; Biotransformation; Clinical Trials as Topic; Diazepam; Half-Life; He | 1977 |
Sedation for gastroscopy: a comparative study of midazolam and Diazemuls in patients with and without cirrhosis.
Topics: Adult; Aged; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; Gastroscopy; Humans; L | 1986 |
17 other studies available for diazepam and Cirrhosis, Liver
| Article | Year |
|---|---|
A case of prolonged delirium tremens.
Topics: Adult; Alcohol Withdrawal Delirium; Anti-Anxiety Agents; Diagnosis, Differential; Diazepam; Humans; | 2013 |
Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases.
Topics: Aged; Amino Acids, Branched-Chain; Bilirubin; Biomarkers; Chronic Disease; Cysteine; Diabetes Mellit | 2014 |
Repeated diazepam dosing in cirrhotic patients: cumulation and sedation.
Topics: Adult; Diazepam; Half-Life; Humans; Hypnotics and Sedatives; Kinetics; Liver Cirrhosis; Male; Middle | 1983 |
Differential effects of hepatic cirrhosis on the plasma protein binding of drugs.
Topics: Blood Proteins; Diazepam; Digitoxin; Female; Humans; Liver Cirrhosis; Male; Pharmaceutical Preparati | 1984 |
Clinical effects and metabolism of diazepam in patients with chronic liver disease.
Topics: Adult; Behavior; Chronic Disease; Diazepam; Humans; Liver Cirrhosis; Liver Diseases; Middle Aged; Ps | 1982 |
[Effect of diazepam on the EEG in cirrhotic patients. Detection of the risk of hepatic encephalopathy].
Topics: Diazepam; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Risk | 1980 |
Effect of narcotic agents and of bleeding on systemic and renal haemodynamics in healthy and CCl4-treated cirrhotic rats.
Topics: Animals; Blood Pressure; Butyrophenones; Carbon Tetrachloride; Diazepam; Disease Models, Animal; Dru | 1997 |
Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake.
Topics: Animals; Benzodiazepines; Binding, Competitive; Cell Fractionation; Cerebellum; Chronic Disease; Clo | 1998 |
Disposition and elimination of minor tranquilizers in the aged and in patients with liver disease.
Topics: Aged; Aging; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hepatitis; Humans; Liver Cirrhosis; Li | 1978 |
Effects of liver disease and of aging on the disposition and elimination of sedatives.
Topics: Aging; Anti-Anxiety Agents; Chlordiazepoxide; Chlorpromazine; Diazepam; Half-Life; Hepatitis, Viral, | 1978 |
Differentiated effects of liver cirrhosis on the albumin binding sites for diazepam, salicylic acid and warfarin.
Topics: Adult; Aged; Binding Sites; Circular Dichroism; Dialysis; Diazepam; Female; Humans; In Vitro Techniq | 1978 |
Pharmacokinetics of diazepam in disordered liver function.
Topics: Adult; Aged; Chromatography, Gas; Diazepam; Female; Half-Life; Humans; Injections, Intravenous; Kine | 1976 |
The effects of age and liver disease on the disposition and elimination of diazepam in adult man.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Aging; Alcoholism; Animals; Diazepam; Fe | 1975 |
Plasma protein binding of ethinyloestradiol: effect of disease and interaction with drugs.
Topics: Adult; Aged; Blood Proteins; Diazepam; Digitoxin; Drug Interactions; Ethinyl Estradiol; Female; Huma | 1989 |
The influence of an experimental liver cirrhosis upon the metabolism of diazepam and imipramine hydrochloride in the rat.
Topics: Animals; Bile; Carbon Radioisotopes; Diazepam; Glucuronates; Glucuronidase; Imipramine; Liver Cirrho | 1985 |
Rupture of esophagus during use of Mengstaken-Blakemore tube.
Topics: Alcoholism; Diazepam; Duodenum; Enteritis; Esophageal and Gastric Varices; Esophageal Diseases; Esop | 1974 |
Clinical and electroencephalographic assessment of diazepam in liver disease.
Topics: Alcoholism; Budd-Chiari Syndrome; Cholestasis; Chronic Disease; Consciousness; Diazepam; Electroence | 1971 |