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diazepam and Chronic Kidney Failure

diazepam has been researched along with Chronic Kidney Failure in 13 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Research Excerpts

ExcerptRelevanceReference
"A 56-year-old man developed allergic interstitial nephritis and deterioration of preexisting chronic renal failure after receiving diazepam."7.67Allergic interstitial nephritis due to diazepam. ( McLaughlin, K; Sadjadi, SA; Shah, RM, 1987)
"The effect of chronic renal disease on the serum free fraction of phenytoin, diazepam and propranolol was examined in vitro among 60 conservatively treated patients with renal insufficiency of varying degree and different etiology, and in 10 patients with a nephrotic syndrome."3.67Serum protein binding of phenytoin, diazepam and propranolol in chronic renal diseases. ( Neuvonen, PJ; Tallgren, LG; Tiula, E, 1987)
"A 56-year-old man developed allergic interstitial nephritis and deterioration of preexisting chronic renal failure after receiving diazepam."3.67Allergic interstitial nephritis due to diazepam. ( McLaughlin, K; Sadjadi, SA; Shah, RM, 1987)
"The plasma protein binding of diazepam and lidocaine was measured in patients with renal disease (those with uremia, nephrotic syndrome, or who had received a transplant) and in age- and sex- matched control subjects."3.66Diazepam and lidocaine plasma protein binding in renal disease. ( Davis, D; Grossman, SH; Kitchell, BB; Routledge, PA; Shand, DG, 1982)
" Uremic toxins were also incubated with purified human albumin, and dose-response experiments with the two most toxic agents in terms of protein damage (guanidine and guanidinopropionic acid) were carried out."1.32Plasma protein aspartyl damage is increased in hemodialysis patients: studies on causes and consequences. ( D'Aniello, A; De Santo, NG; Galletti, P; Ingrosso, D; Lombardi, C; Perna, AF; Satta, E, 2004)
" Pharmacokinetic variable values in elderly subjects did not differ in a clinically significant manner from those in younger subjects."1.28Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam. ( Karim, A; Nicholson, PA; Smith, M, 1990)
"5 patients with chronic renal failure on maintenance hemodialysis and 5 healthy matched controls received single 20-mg intravenous doses of clorazepate dipotassium."1.27Clorazepate dipotassium and diazepam in renal insufficiency: serum concentrations and protein binding of diazepam and desmethyldiazepam. ( Greenblatt, DJ; Kaschell, HJ; Ochs, HR; Rauh, HW, 1984)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19909 (69.23)18.7374
1990's2 (15.38)18.2507
2000's2 (15.38)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Perna, AF1
Ingrosso, D1
Satta, E1
Lombardi, C1
Galletti, P1
D'Aniello, A1
De Santo, NG1
Nishio, T1
Takamura, N1
Nishii, R1
Tokunaga, J1
Yoshimoto, M1
Kawai, K1
Ochs, HR1
Rauh, HW1
Greenblatt, DJ2
Kaschell, HJ1
Gulyassy, PF1
Depner, TA1
Grossman, SH1
Davis, D1
Kitchell, BB1
Shand, DG1
Routledge, PA1
Both, R1
Mühlau, G1
Neumann, J1
Sperschneider, H1
Stein, G1
Taclob, L1
Needle, M1
Harmatz, JS1
Shader, RI1
Owada, S1
Toyama, K1
Maeba, T1
Ishida, M1
Nicholson, PA1
Karim, A1
Smith, M1
Pacifici, GM1
Viani, A1
Rizzo, G1
Carrai, M1
Tiula, E1
Tallgren, LG1
Neuvonen, PJ1
Sadjadi, SA1
McLaughlin, K1
Shah, RM1

Reviews

1 review available for diazepam and Chronic Kidney Failure

ArticleYear
Impaired binding of drugs and endogenous ligands in renal diseases.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1983, Volume: 2, Issue:6

    Topics: Apazone; Bilirubin; Binding Sites; Carrier Proteins; Diazepam; Digitoxin; Fatty Acids, Nonesterified

1983

Trials

1 trial available for diazepam and Chronic Kidney Failure

ArticleYear
Influences of haemodialysis on the binding sites of human serum albumin: possibility of an efficacious administration plan using binding inhibition.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2008, Volume: 23, Issue:7

    Topics: Adult; Aged; Barbiturates; Binding Sites; Carbon Radioisotopes; Diazepam; Diuretics; Fatty Acids, No

2008

Other Studies

11 other studies available for diazepam and Chronic Kidney Failure

ArticleYear
Plasma protein aspartyl damage is increased in hemodialysis patients: studies on causes and consequences.
    Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:10

    Topics: Asparagine; Aspartic Acid; Biomarkers; Blood Chemical Analysis; Blood Proteins; Diazepam; Female; Hu

2004
Clorazepate dipotassium and diazepam in renal insufficiency: serum concentrations and protein binding of diazepam and desmethyldiazepam.
    Nephron, 1984, Volume: 37, Issue:2

    Topics: Adult; Aged; Anti-Anxiety Agents; Clorazepate Dipotassium; Diazepam; Dose-Response Relationship, Dru

1984
Diazepam and lidocaine plasma protein binding in renal disease.
    Clinical pharmacology and therapeutics, 1982, Volume: 31, Issue:3

    Topics: Adult; Aged; Blood Proteins; Diazepam; Fatty Acids, Nonesterified; Female; Humans; Kidney Diseases;

1982
[The problem of the so-called dialysis encephalopathy].
    Sammlung zwangloser Abhandlungen aus dem Gebiete der Psychiatrie und Neurologie, 1982, Volume: 50

    Topics: Adolescent; Adult; Brain Damage, Chronic; Dementia; Diazepam; Electroencephalography; Evoked Potenti

1982
Drug-induced encephalopathy in patients on maintenance haemodialysis.
    Lancet (London, England), 1976, Oct-02, Volume: 2, Issue:7988

    Topics: Aged; Anti-Anxiety Agents; Arthritis; Coronary Disease; Dementia; Diazepam; Flurazepam; Fractures, B

1976
Sex differences in diazepam protein binding in patients with renal insufficiency.
    Pharmacology, 1978, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Age Factors; Aged; Creatinine; Diazepam; Female; Humans; Kidney Failure, Chronic;

1978
[Uremic pruritus in chronic kidney failure with hemodialysis].
    Nihon rinsho. Japanese journal of clinical medicine, 1992, Volume: 50 Suppl

    Topics: Diazepam; Histamine; Histamine Antagonists; Humans; Kidney Failure, Chronic; Lidocaine; Parathyroide

1992
Pharmacokinetics of misoprostol in the elderly, in patients with renal failure and when coadministered with NSAID or antipyrine, propranolol or diazepam.
    The Journal of rheumatology. Supplement, 1990, Volume: 20

    Topics: Adult; Aged; Aging; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Diazepam; Drug

1990
Plasma protein binding of ethinyloestradiol: effect of disease and interaction with drugs.
    International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:7

    Topics: Adult; Aged; Blood Proteins; Diazepam; Digitoxin; Drug Interactions; Ethinyl Estradiol; Female; Huma

1989
Serum protein binding of phenytoin, diazepam and propranolol in chronic renal diseases.
    International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:10

    Topics: Creatinine; Diazepam; Humans; Kidney Failure, Chronic; Nephrotic Syndrome; Orosomucoid; Phenytoin; P

1987
Allergic interstitial nephritis due to diazepam.
    Archives of internal medicine, 1987, Volume: 147, Issue:3

    Topics: Diazepam; Drug Hypersensitivity; Eosinophilia; Eosinophils; Humans; Kidney Failure, Chronic; Male; M

1987
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