diazepam has been researched along with Chemical Dependence in 470 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketotifen was compared to diazepam to inhibit aversive responding of the mouse in a black and white test box and in the rat social interaction test." | 5.28 | The effect of ketotifen in rodent models of anxiety and on the behavioural consequences of withdrawing from treatment with drugs of abuse. ( Costall, B; Kelly, ME; Naylor, RJ; Onaivi, ES, 1990) |
| "Diazepam has well-known amnestic properties." | 5.27 | Diazepam-induced amnesia: a neuropharmacological model of an "organic amnestic syndrome". ( Hommer, DW; Paul, SM; Pickar, D; Thompson, K; Weingartner, H; Wolkowitz, OM, 1987) |
| "The relationship between family history of alcoholism and risk for benzodiazepine abuse was examined by assessing the reinforcing and subjective effects of diazepam (DZ; 4-28 mg) in 14 normal (i." | 5.07 | Diazepam preference in males with and without an alcoholic first-degree relative. ( de Wit, H, 1991) |
| " Diazepam is the most effective drug for cocaine-induced seizures." | 4.78 | Neurologic complications of cocaine abuse. ( Euerle, B; Spivey, WH, 1990) |
| "Diazepam and lorazepam were more euphoriant than placebo; alprazolam's euphoriant effect did not differ from these treatments." | 3.76 | Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo. ( Beake, B; Bird, M; Cole, JO; Dessain, E; Friedman, L; McEachern, J; Orzack, MH, 1988) |
| " In one approach, mice were chronically treated with either diazepam, clonazepam, clobazam or the novel anxiolytic and anticonvulsant beta-carboline derivative abecarnil for 4 weeks, at doses which were about equipotent to increase the threshold for myoclonic seizures induced by pentylenetetrazole." | 3.69 | Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil. ( Ebert, U; Hönack, D; Löscher, W; Rundfeldt, C, 1996) |
| " Mice withdrawn from chronic treatment with diazepam showed a time-related evolution of anxiety, muscle rigidity, and seizures between days 4 and 21 after treatment discontinuation." | 3.68 | Diazepam dependence prevented by glutamate antagonists. ( Steppuhn, KG; Turski, L, 1993) |
| " In BDZ-dependent animals the BDZ-receptor antagonist flumazenil (Ro 15-1788) reverses the increased anxiety and decreased seizure threshold seen when benzodiazepine treatment is withdrawn." | 3.68 | A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena. ( File, SE; Hitchcott, PK, 1990) |
| " Both of the mothers were on methadone maintenance for narcotic dependency prior to the diagnosis of pregnancy." | 3.68 | Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate. ( Hinderliter, SA; Sutton, LR, 1990) |
| "In a prospective study over 6 months involving 54 psychiatric outpatients with neurotic disorders, the habits of diazepam or placebo intake and the attitudes towards psychotherapy and the medication were studied." | 3.66 | Long-term treatment with diazepam. Investigation of consumption habits and the interaction between psychotherapy and psychopharmacotherapy: a prospective study. ( Balmer, R; Battegay, R; von Marschall, R, 1981) |
| "Drug addiction during pregnancy has been managed in two ways: the detoxification program and the methadone-maintenance treatment program." | 3.65 | Drug addiction in pregnancy and the neonate. ( Ackerman, BD; Blinick, G; Jerez, E; Wallach, RC, 1976) |
| " After the switch to diazepam, the dosage was gradually tapered according to a standardized protocol." | 3.11 | Discontinuation of chronic benzodiazepine use in primary care: a nonrandomized intervention. ( Aguiar, P; Alvim, A; Atalaia, P; Fernandes, M; Freitas, MC; Maria, V; Matos, F; Neves, I; Oliveira, J; Santos, O, 2022) |
| "8); a lower daily benzodiazepine dosage at the start of tapering off (HR 1." | 2.72 | Predictors of long-term benzodiazepine abstinence in participants of a randomized controlled benzodiazepine withdrawal program. ( Breteler, MH; Gorgels, WJ; Mol, AJ; Mulder, J; van Balkom, AJ; van de Lisdonk, EH; Voshaar, RC; Zitman, FG, 2006) |
| " Both groups showed a reduction in benzodiazepine dosage of 86% over the first 8 days which was maintained at 1 month post-discharge." | 2.71 | In-patient benzodiazepine withdrawal: comparison of fixed and symptom-triggered taper methods. ( Machin, A; McGregor, C; White, JM, 2003) |
| "The aim of this study is to determine whether long-term use (5-20 years) of therapeutic doses of diazepam (5-20 mg/day) in anxious patients (n = 28) is associated with tolerance to its psychomotor and cognitive effects." | 2.67 | Differential acute psychomotor and cognitive effects of diazepam on long-term benzodiazepine users. ( Bernik, MA; Gorenstein, C; Pompéia, S, 1994) |
| "Diazepam choice was also associated with more frequent recreational use of marijuana and stimulants." | 2.67 | Relationship between subjective effects and drug preferences: ethanol and diazepam. ( Chutuape, MA; de Wit, H, 1994) |
| " Pharmacodynamic measures included subjective (euphoria, subject liking, sedation, and symptoms) and behavioral (signs and observed liking) responses." | 2.67 | Single-dose pharmacodynamics of diazepam and pentobarbital in substance abusers. ( Jasinski, DR; Johnson, RE; Sullivan, JT, 1993) |
| " After four weeks the dosage was reduced in 25% quantities until no further benzodiazepines were taken." | 2.67 | A double-blind comparison of the effects of gradual withdrawal of lorazepam, diazepam and bromazepam in benzodiazepine dependence. ( Murphy, SM; Tyrer, P, 1991) |
| "When alprazolam and diazepam were tested using the altered equivalent ratio of 1:14, "liking" and "seeking potentials" revealed no significant differences." | 2.67 | Preference for alprazolam as opposed to diazepam in benzodiazepine-dependent psychiatric inpatients. ( Apelt, S; Emrich, HM; Schmauss, C, 1990) |
| " Mean daily diazepam dosage at entry was significantly higher in the buspirone group, but overall initial diazepam dosage was not related to outcome." | 2.67 | A double-blind placebo-controlled study of buspirone in diazepam withdrawal in chronic benzodiazepine users. ( Ashton, CH; Rawlins, MD; Tyrer, SP, 1990) |
| " Neither the maximal clinical dosage of tizanidine (3 mg) nor twice that dosage (6 mg) induced any marked somatic or psychic symptoms compared with the placebo." | 2.66 | Effects of tizanidine in healthy volunteers: double-blind study compared with diazepam and a placebo. ( Igarashi, S; Yamamura, H; Yanagita, T, 1988) |
| " Six subjects received 80 mg DZ every third day (3 subjects) or every sixth day (3 subjects) for a total of 3-6 dosing occasions and six subjects received TZ (2." | 2.66 | Repeated administration of diazepam and triazolam to subjects with histories of drug abuse. ( Griffiths, RR; Roache, JD, 1986) |
| "Diazepam was categorized as producing barbiturate-like subjective effects (38." | 2.65 | Relative abuse liability of diazepam and oxazepam: behavioral and subjective dose effects. ( Bigelow, GE; Griffiths, RR; Liebson, IA; McLeod, DR; Roache, JD, 1984) |
| " Thus, with long-term administration of diszepam, even in therapeutically accepted doses, withdrawal reactions can be encountered on abrupt termination." | 2.65 | Withdrawal reaction from long-term, low-dosage administration of diazepam. A double-blind, placebo-controlled case study. ( Greenblatt, DJ; Rickels, K; Schatz, NJ; Snyder, PJ; Winokur, A, 1980) |
| " Uncontrolled long-term administration is to be rejected in all circumstances, and supply should be strictly on prescription only in order to prevent uncontrolled acquisition." | 2.64 | The use of tranquilizers in the treatment of mixed drug abuse. ( Demel, I; Kryspin-Exner, K, 1975) |
| " Dose reduction does not change external appearance of the dosage form, and the patient could be treated until the placebo phase." | 2.61 | New approach for detoxification of patients dependent on benzodiazepines and Z-drugs for reduction of psychogenic complications. ( Franc, A; Kubová, K; Šaloun, J; Vetchý, D; Vysloužil, J, 2019) |
| "Many patients with alcohol or drug abuse also have anxiety disorders for whom effective pharmacotherapy may be needed." | 2.38 | Alprazolam and benzodiazepine dependence. ( Ciraulo, DA; DuPont, RL; Griffiths, RR; Kosten, TR; Romach, MK; Sellers, EM; Woody, GE, 1993) |
| "Alprazolam has a shorter half-life, which may lead to more withdrawal symptoms than diazepam." | 2.38 | Alprazolam and diazepam: addiction potential. ( Juergens, S, 1991) |
| "However, withdrawal symptoms may occur in patients receiving recommended doses and/or short-term therapy." | 2.36 | Benzodiazepine withdrawal syndrome: a literature review and evaluation. ( MacKinnon, GL; Parker, WA, 1982) |
| "Clonazepam is a new benzodiazepine anticonvulsant recently approved by the Food and Drug Administration for the treatment of typical absence, infantile myoclonic, atypical absence, myoclonic, and akinetic seizures." | 2.35 | Clonazepam. A review of a new anticonvulsant drug. ( Browne, TR, 1976) |
| " This case highlights the lack of adolescent-friendly facilities allowing safe tapering of rapid-acting benzodiazepines in North America." | 1.62 | Severe Benzodiazepine Use Disorder in a 16-Year-Old Adolescent: A Rapid and Safe Inpatient Taper. ( Chadi, A; Chadi, N; Fournier, C; Jamoulle, O, 2021) |
| "Hair specimen is necessary to complement blood and/or urine analyses as it permits differentiation of a single exposure from chronic use of a drug by segmentation of the hair for a stated growth period." | 1.42 | Contribution of in utero drug exposure when interpreting hair results in young children. ( Kintz, P, 2015) |
| "Propofol is an addictive drug, and the problem of its abuse and dependence has occurred." | 1.42 | Increased use in propofol and reported patterns of adverse events among anesthetics in Korea. ( Kim, MH; Park, BJ; Park, HJ; Shin, JY, 2015) |
| "The diagnosis of drug dependence was based on the three criteria: symptoms of pathological dependence of benzodiazepine, benzodiazepine withdrawal syndrome with severe somatic/autonomic symptoms and exacerbation of dependence, increase in tolerability to benzodiazepine anxiolytics and hypnotics; 64." | 1.42 | [Remote consequences of the long-term uncontrollable consumption of anxiolytics and hypnotics in elderly: a problem of drug dependence]. ( Avdeeva, TI; Ivanets, NN; Kinkulkina, MA; Tikhonova, YG, 2015) |
| "The results showed that drug abusers exhibited significantly shorter LTLs than controls (P = 1." | 1.39 | Drug addiction is associated with leukocyte telomere length. ( Cao, L; Cui, D; He, L; He, S; Li, C; Liu, Y; Qi, G; Shen, Q; Wang, T; Wu, J; Yang, Z; Ye, J; Zhou, D, 2013) |
| "Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together." | 1.39 | Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans. ( Augustin, I; Begemann, M; Brose, N; Ehrenreich, H; Gurvich, A; Ju, A; Man, KN; Müller-Ribbe, K; Papiol, S; Ronnenberg, A; Shin, Y; Stepniak, B; Tantra, M; Wojcik, SM, 2013) |
| " Hippocampal synaptic plasticity has been related to learning, memory, and adaptive processes developed during chronic administration of drug abuse." | 1.36 | Changes in hippocampal arc protein expression and synaptic plasticity by the presentation of contextual cues linked to drug experience. ( Almirón, RS; Bignante, EA; Monti, MC; Ramírez, OA, 2010) |
| "Diazepam dependence has distinctive characteristics that make it undetected by SCAN." | 1.34 | Chronic use of diazepam in primary healthcare centers: user profile and usage pattern. ( Azevedo, RC; Botega, NJ; Ribeiro, CS; Silva, VF, 2007) |
| "Diazepam is a benzodiazepine used in the treatment of anxiety, insomnia and seizures, but with the potential for abuse." | 1.33 | Acetylcholine in the accumbens is decreased by diazepam and increased by benzodiazepine withdrawal: a possible mechanism for dependency. ( Hoebel, BG; Rada, P, 2005) |
| "Prescription drug abuse was reported by 87%; alprazolam (57%), oxycodone (36%), hydrocodone (32%) and diazepam (30%) were cited most often." | 1.33 | Prescription drug abuse among ecstasy users in Miami. ( Cottler, L; Inciardi, JA; Kurtz, SP; Surratt, HL, 2005) |
| " Development of physical dependence during chronic dosing with 0." | 1.32 | Physical dependence in baboons chronically treated with low and high doses of diazepam. ( Griffiths, RR; Kaminski, BJ; Lamb, RJ; Sannerud, CA; Weerts, EM, 2003) |
| "Zolpidem is a nonbenzodiazepine medication approved for the short-term treatment of insomnia." | 1.32 | Detoxification from high-dose zolpidem using diazepam. ( Eraikhuemen, NE; Kearson, ML; Lanes, DM; Larose-Pierre, M; Payne, DR; Rappa, LR, 2004) |
| "This will make the substance abuse program more meaningful." | 1.32 | Self-reported drug use and urinalysis results. ( Jain, R, 2004) |
| "When PK 11195 was administered weekly (5 weeks), rather than daily, tolerance did not develop in either sex." | 1.31 | The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats. ( Holtman, JR; Jing, X; Sloan, JW; Wala, EP, 2000) |
| "Pretreatment with diazepam (0." | 1.31 | Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice. ( Cazala, P; David, V; Gold, LH; Koob, GF, 2001) |
| "These results suggest that, among alcohol abusers, cocaine is a complement to alcohol, but alcohol is a substitute for cocaine." | 1.31 | A behavioral economic analysis of polydrug abuse in alcoholics: asymmetrical substitution of alcohol and cocaine. ( Petry, NM, 2001) |
| "Zopiclone dependence has repeatedly been reported in patients with pre-existing substance-related addictions, and in patients with other psychiatric disorders." | 1.31 | [A case of primary zopiclone dependence]. ( Brüne, M; Kahlert, I, 2001) |
| "The induction of aneuploidy by DZ was also tested in humans." | 1.31 | Induction of aneuploidy in male mouse germ cells detected by the sperm-FISH assay: a review of the present data base. ( Adler, ID; Baumgartner, A; Schmid, TE, 2002) |
| "Nitrazepam was detected most frequently (61 urine samples), but had not been prescribed to any of the patients in this study." | 1.30 | Benzodiazepine misuse by drug addicts. ( Garretty, DJ; Hay, AW; Raistrick, D; Wolff, K, 1997) |
| "Pretreatment with bromocriptine (0." | 1.30 | Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats. ( Gan, Q; Knuepfer, MM, 1997) |
| " FLU evoked dose-related tonic-clonic and clonic convulsions (five out of six rats), whereas PK (10 mg/kg) induced convulsions in only one rat (out of five); tachypnea tended to increase with the dose of both FLU and PK; twitches and jerks, backing and writhing had a significant regression on the dose of FLU; rearing tended to decrease with the dose of PK whereas FLU-evoked head bobbing and PK-evoked twitches and jerks had inverse U-shaped dose-response curves." | 1.30 | Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats. ( Jing, X; Sloan, JW; Wala, EP, 1997) |
| "Alpidem is a new anxiolytic of imidazopyridine structure which has a high affinity for the omega 1 (BZ1) modulatory site of the GABAA receptor." | 1.29 | Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence. ( Morel, E; Perrault, G; Sanger, DJ; Zivkovic, B, 1993) |
| "Imidazenil has a longer half-life than an equipotent dose of diazepam and protects rats against bicuculline-induced convulsions for a significantly longer time than diazepam or bretazenil." | 1.29 | Imidazenil, a partial positive allosteric modulator of GABAA receptors, exhibits low tolerance and dependence liabilities in the rat. ( Auta, J; Costa, E; Giusti, P; Guidotti, A, 1994) |
| "Diazepam was used as a reference." | 1.29 | Long-term treatment with abecarnil does not induce diazepam-like dependence in mice. ( Schneider, HH; Stephens, DN; Steppuhn, KG; Turski, L, 1993) |
| "Physical dependence was produced in the rat by exposure to continuous release of diazepam from silastic capsule implants (recrystallized diazepam) or by dosing through a gastric fistula." | 1.29 | Precipitated abstinence in the diazepam-dependent rat. ( Martin, WR; Sloan, JW; Wala, EP, 1993) |
| " ND and parent OX have similar pharmacokinetic profiles." | 1.29 | Pharmacokinetics of nordiazepam in physical dependence and precipitated abstinence in dogs. ( Martin, WR; Sloan, JW; Wala, EP, 1993) |
| "After stopping the treatment, the body weight and food consumption in the diazepam 100 and 300 mg/kg groups tended to decrease or decreased to values lower than those in the control group, whereas these parameters in the S-(+)-DN-2327 30, 100 and 300 mg/kg groups were comparable to the control group values." | 1.29 | A nonbenzodiazepine partial agonist, S-(+)-DN-2327, has minimal physical dependence-producing liability, but shows cross-dependence on barbital in rats. ( Awasaki, Y; Inui, Y; Nishida, N; Yamamoto, M, 1996) |
| " Therefore, it seems that when chronic administration of diazepam is accompanied by chronic stress, tolerance does not occur to the anxiolytic effects, although it does develop to the sedative effects." | 1.29 | Noise stress and the development of benzodiazepine dependence in the rat. ( Fernandes, C; File, SE, 1994) |
| "Enciprazine was selected for clinical investigations." | 1.28 | Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds. ( Engel, J; Fleischhauer, I; Jakovlev, V; Johanson, CE; Kleemann, A; Kutscher, B; Nickel, B; Rauer, H; Szelenyi, I; Werner, U, 1990) |
| " We report five cases of high-dose triazolam abuse in which the daily dosage ranged from 5 to 15 mg (100-300 mg diazepam equivalent) and the duration of use ranged from 3 months to 5 years." | 1.28 | Detoxification for triazolam physical dependence. ( Sellers, EM; Sullivan, JT, 1992) |
| "This work was performed to compare withdrawal symptoms induced by the administration of the central vs." | 1.28 | Physical dependence on diazepam: precipitation of abstinence syndromes by peripheral and central benzodiazepine receptor antagonists. ( Bueno, L; Fargeas, MJ; Martinez, JA, 1992) |
| " Rats were chronically fed food containing diazepam on an escalating drug dosage schedule, from 1 and 2 to 12 mg/g of food, over a period of 30 days." | 1.28 | Genetic differences in the development of physical dependence upon diazepam in Lewis and Fischer 344 inbred rat strains. ( Lu, MS; Misawa, M; Motegi, H; Suzuki, T; Yoshii, T, 1992) |
| " Using a cumulative dosing procedure, PTZ substituted for PTZ, and MDZ, chlordiazepoxide and diazepam (DZP) substituted for MDZ, in a dose-dependent manner." | 1.28 | Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam. ( Boone, MS; Emmett-Oglesby, MW; Pugh, SL, 1992) |
| "Fundamental withdrawal symptoms (like hypersensitivity to sensory stimuli, abnormal perception of movement, depersonalisation or derealisation) were also less severe in the group treated with CBZ compared with the group not receiving that treatment." | 1.28 | Treatment of benzodiazepine withdrawal symptoms with carbamazepine. ( Apelt, S; Bronisch, T; Emrich, HM; Garcia-Borreguero, D; Yassouridis, A, 1991) |
| "Dogs dosed chronically (4-7 weeks) with oral flunitrazepam (7." | 1.28 | A comparison of the physical dependence inducing properties of flunitrazepam and diazepam. ( Martin, WR; Sloan, JW; Wala, EP, 1991) |
| " Flupirtine yielded a dose-response curve with an ED50 of 3." | 1.28 | Investigations with the novel non-opioid analgesic flupirtine in regard to possible benzodiazepine-like abuse inducing potential. ( Borbe, HO; Nickel, B; Szelenyi, I, 1990) |
| "treatment with alprazolam induced clear physical dependence in DBA/2J mice as assessed by precipitation of a withdrawal syndrome with an i." | 1.28 | Physical dependence induced in DBA/2J mice by benzodiazepine receptor full agonists, but not by the partial agonist Ro 16-6028. ( Haefely, WE; Jenck, F; Martin, JR; Moreau, JL; Pieri, L; Schoch, P, 1990) |
| "Ketotifen was compared to diazepam to inhibit aversive responding of the mouse in a black and white test box and in the rat social interaction test." | 1.28 | The effect of ketotifen in rodent models of anxiety and on the behavioural consequences of withdrawing from treatment with drugs of abuse. ( Costall, B; Kelly, ME; Naylor, RJ; Onaivi, ES, 1990) |
| "When diazepam was used as the dependence-producing drug, a 2." | 1.28 | Ethanol and diazepam withdrawal convulsions are extensively codetermined in WSP and WSR mice. ( Belknap, JK; Crabbe, JC; Laursen, SE, 1989) |
| " A tapering schedule was carried out during a 12-day stay in the hospital in which the diazepam dosage was reduced by a fixed quantity every day, corresponding to about ten percent of the initial dosage." | 1.28 | Panic attacks and major depression after discontinuation of long-term diazepam abuse. ( Magni, G; Schifano, F, 1989) |
| "Dogs, surgically implanted with a gastric fistula, were chronically dosed with diazepam or lorazepam." | 1.27 | Physical dependence on diazepam and lorazepam in the dog. ( Cherian, S; Martin, WR; McNicholas, LF, 1983) |
| " Pupil diameter and subjective responses were measured 15 min before dosing and 15, 30, 45, 60, 90, and 120 min after dosing." | 1.27 | Diazepam and methadone interactions in methadone maintenance. ( Bigelow, GE; Griffiths, RR; Liebson, IA; Preston, KL; Stitzer, ML, 1984) |
| " Antidepressant medications, both TCAs and MAOIs, often help relieve the symptoms of depression that emerge when chronic use of cocaine is discontinued." | 1.27 | Cocaine abuse and its treatment. ( Resnick, EB; Resnick, RB, 1984) |
| "Zopiclone was self-administered by rhesus monkeys relatively frequently by the intravenous route; the infrequent intragastric rate was similar to or slightly higher than with diazepam." | 1.27 | Dependence potential of zopiclone studied in monkeys. ( Yanagita, T, 1983) |
| "Diazepam was categorized as producing barbiturate-like subjective effects more frequently than was oxazepam (54 vs." | 1.27 | Comparison of diazepam and oxazepam: preference, liking and extent of abuse. ( Bigelow, GE; Griffiths, RR; Liebson, IA; McLeod, DR; Nowowieski, P; Roache, JD, 1984) |
| "Diazepam was administered to Swiss-Webster mice for 53 days as a mixture of drug in laboratory chow, leading to consumption as high as 1000 mg/kg/day." | 1.27 | Benzodiazepine dependence in mice after ingestion of drug-containing food pellets. ( Gallaher, EJ; Henauer, SA; Hollister, LE; Jacques, CJ, 1986) |
| "CGS-8216, a benzodiazepine antagonist, was administered to rats acutely dosed with diazepam, and to rats chronically dosed with diazepam or pentobarbital." | 1.27 | Benzodiazepine antagonist, CGS-8216, in diazepam- or pentobarbital-dependent and non-dependent rats. ( Martin, WR; McNicholas, LF, 1986) |
| " Flumazenil caused dose-related increases in the NPAS scores of both diazepam- and nordiazepam-dependent dogs; the slopes of the two dose-response lines were not different." | 1.27 | Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs. ( Martin, WR; McNicholas, LF; Sloan, JW; Wala, E, 1988) |
| "Physical dependence was rapidly induced in mice by administering diazepam intraperitoneally twice daily using an incremental dosing regimen (50 to 450 mg/kg) for nine consecutive days." | 1.27 | A simple and rapid method of inducing physical dependence with benzodiazepines in mice. ( Malick, JB; Patel, JB; Rinarelli, CA, 1988) |
| " In a separate experiment, Ro 15-1788 produced a PTZ-like stimulus when given at 2-day intervals during chronic administration of DZP." | 1.27 | Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol. ( Emmett-Oglesby, MW; Harris, CM; Idemudia, SO; Lal, H; Mathis, DA, 1988) |
| "7 mg/kg/day), on the gradedly increased dosage schedule with a dosage level of 0." | 1.27 | [Physical dependence liability test of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) in rats]. ( Imamaki, H; Ogawa, K; Suzuki, T; Yanaura, S; Yoshii, T, 1987) |
| "8 mg/kg/d was tested in experiments with chronic administration for 4 weeks." | 1.27 | Physical dependence capacity of brotizolam in rhesus monkeys. 1st communication: primary dependence studies. ( Bechtel, WD; Stockhaus, K, 1986) |
| " During chronic administration of brotizolam, triazolam and diazepam all animals gained body weight." | 1.27 | Physical dependence capacity of brotizolam in rhesus monkeys. 2nd communication: primary dependence and barbital substitution. ( Stockhaus, K, 1986) |
| "Diazepam has well-known amnestic properties." | 1.27 | Diazepam-induced amnesia: a neuropharmacological model of an "organic amnestic syndrome". ( Hommer, DW; Paul, SM; Pickar, D; Thompson, K; Weingartner, H; Wolkowitz, OM, 1987) |
| "Mequitazine is a new phenothiazine derivative with potent antihistaminic activity developed by Pharmuka, Co." | 1.26 | [Studies on the barbital-type physical dependence liability of mequitazine in mice and rats (author's transl)]. ( Kaneto, H, 1981) |
| "Diazepam was used for relief of pain or muscle spasm, or anxiety and sleeplessness associated with these two symptoms, and was considered to be beneficial by 83% of the patients, although use of other drugs confounded this evaluation." | 1.26 | Long-term use of diazepam. ( Britt, RH; Conley, FK; Hollister, LE; Shuer, L, 1981) |
| "Zopiclone was self-administered by rhesus monkeys relatively frequently by the intravenous route; the infrequent intragastric rate was similar to or slightly higher than with diazepam." | 1.26 | Dependence potential of zopiclone studied in monkeys. ( Yanagita, T, 1982) |
| "Experienced polydrug abusers (N = 190) were asked to indicate previous drugs used as well as drug preferences." | 1.26 | Indicated preference for drugs of abuse. ( Kliner, DJ; Pickens, R, 1982) |
| "Methadone maintenance patients who use benzodiazepine drugs were interviewed about the dosage levels, patterns, frequency and motives for their use of these drugs." | 1.26 | Diazepam use among methadone maintenance patients: patterns and dosages. ( Grabowski, J; Griffiths, RR; Hawthorne, JW; McLellan, AT; Stitzer, ML, 1981) |
| "Early detection and treatment of drug abuse should minimize some of the difficulties involved in management of treatment-resistive patients with chronic pain." | 1.26 | Drug abuse and dependency in patients with chronic pain. ( Finlayson, RE; Maruta, T; Swanson, DW, 1979) |
| "Thrombocytosis was not related to withdrawal symptoms or treatment (phenobarbital or paregoric)." | 1.26 | Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users. ( Burstein, Y; Giardina, PJ; Kandall, SR; Peterson, CM; Rausen, AR; Siljestrom, K, 1979) |
| "Diazepam was present in elevated concentrations, and its depressant effect may have been a factor in some narcotic addiction deaths." | 1.26 | Some observations concerning blood morphine concentrations in narcotic addicts. ( Monforte, JR, 1977) |
| "Severe withdrawal symptoms such as tremulousness, irritability, increased psychomotor activity, generalized muscle cramps, photophobia, retro-orbital pains and insomnia are described." | 1.26 | Diazepam addiction: a case report. ( Agrawal, P, 1978) |
| "Generalized motor seizures and myoclonic jerks were the predominant convulsive manifestations." | 1.26 | Neonatal seizures associated with narcotic withdrawal. ( Herzlinger, RA; Kandall, SR; Vaughan, HG, 1977) |
| " The rats (drug dependence-experimented rats) who survived the first stage of this experiment were continuously subjected to re-administration by the same dosage schedule as in Exp." | 1.25 | [Comparison of development of drug dependence in naive and drug dependence-experienced rats]. ( Tagashira, E; Yanaura, S, 1975) |
| " Physical dependence on phenobarbital and diazepam was produced using the same dosage schedules as with morphine." | 1.25 | Physical dependence on morphine, phenobarbital and diazepam in rats by drug-admixed food ingestion. ( Suzuki, T; Tagashira, E; Yanaura, S, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 295 (62.77) | 18.7374 |
| 1990's | 97 (20.64) | 18.2507 |
| 2000's | 44 (9.36) | 29.6817 |
| 2010's | 27 (5.74) | 24.3611 |
| 2020's | 7 (1.49) | 2.80 |
| Authors | Studies |
|---|---|
| Engel, J | 1 |
| Fleischhauer, I | 1 |
| Jakovlev, V | 1 |
| Kleemann, A | 1 |
| Kutscher, B | 1 |
| Nickel, B | 2 |
| Rauer, H | 1 |
| Werner, U | 1 |
| Szelenyi, I | 2 |
| Johanson, CE | 9 |
| Jacobsen, EJ | 1 |
| Stelzer, LS | 1 |
| Belonga, KL | 1 |
| Carter, DB | 1 |
| Im, WB | 1 |
| Sethy, VH | 1 |
| Tang, AH | 1 |
| VonVoigtlander, PF | 1 |
| Petke, JD | 1 |
| Basińska-Szafrańska, A | 2 |
| Fernandes, M | 1 |
| Neves, I | 1 |
| Oliveira, J | 1 |
| Santos, O | 1 |
| Aguiar, P | 1 |
| Atalaia, P | 1 |
| Matos, F | 1 |
| Freitas, MC | 1 |
| Alvim, A | 1 |
| Maria, V | 1 |
| Wilson, CD | 1 |
| Zheng, F | 1 |
| Fantegrossi, WE | 1 |
| Walde, J | 1 |
| Andersson, L | 1 |
| Johnson, B | 1 |
| Håkansson, A | 1 |
| Kubová, K | 1 |
| Franc, A | 1 |
| Vysloužil, J | 1 |
| Šaloun, J | 1 |
| Vetchý, D | 1 |
| Chan, WL | 1 |
| Dargan, PI | 2 |
| Haynes, CM | 1 |
| Green, JL | 1 |
| Black, JC | 1 |
| Dart, RC | 1 |
| Wood, DM | 2 |
| Fournier, C | 1 |
| Jamoulle, O | 1 |
| Chadi, A | 1 |
| Chadi, N | 1 |
| Soyka, M | 1 |
| Tvete, IF | 2 |
| Bjørner, T | 2 |
| Skomedal, T | 2 |
| Abouchedid, R | 1 |
| Gilks, T | 1 |
| Archer, JRH | 1 |
| Azanza Balmori, A | 1 |
| García Álvarez, G | 1 |
| Rodríguez Turiel, C | 1 |
| Povedano Suárez, EA | 1 |
| Muquebil Ali Al Shaban Rodríguez, OW | 1 |
| Lauhan, R | 1 |
| Hsu, A | 1 |
| Alam, A | 1 |
| Beizai, K | 1 |
| Haider, S | 1 |
| Nawaz, A | 1 |
| Batool, Z | 1 |
| Tabassum, S | 1 |
| Perveen, T | 1 |
| Yang, Z | 1 |
| Ye, J | 1 |
| Li, C | 1 |
| Zhou, D | 1 |
| Shen, Q | 1 |
| Wu, J | 1 |
| Cao, L | 1 |
| Wang, T | 1 |
| Cui, D | 1 |
| He, S | 1 |
| Qi, G | 1 |
| He, L | 1 |
| Liu, Y | 1 |
| Burch, HJ | 1 |
| Clarke, EJ | 1 |
| Hubbard, AM | 1 |
| Scott-Ham, M | 1 |
| Wojcik, SM | 1 |
| Tantra, M | 1 |
| Stepniak, B | 1 |
| Man, KN | 1 |
| Müller-Ribbe, K | 1 |
| Begemann, M | 1 |
| Ju, A | 1 |
| Papiol, S | 1 |
| Ronnenberg, A | 1 |
| Gurvich, A | 1 |
| Shin, Y | 1 |
| Augustin, I | 1 |
| Brose, N | 1 |
| Ehrenreich, H | 1 |
| Papp, M | 1 |
| Gruca, P | 1 |
| Lason-Tyburkiewicz, M | 1 |
| Litwa, E | 1 |
| Willner, P | 1 |
| Bertol, E | 1 |
| Mari, F | 1 |
| Boscolo Berto, R | 1 |
| Mannaioni, G | 1 |
| Vaiano, F | 1 |
| Favretto, D | 1 |
| Kintz, P | 1 |
| Nordal, K | 1 |
| Øiestad, EL | 1 |
| Enger, A | 1 |
| Christophersen, AS | 1 |
| Vindenes, V | 1 |
| Shin, JY | 2 |
| Lee, SH | 1 |
| Shin, SM | 1 |
| Kim, MH | 2 |
| Park, SG | 1 |
| Park, BJ | 2 |
| Park, HJ | 1 |
| Lakehayli, S | 1 |
| Said, N | 1 |
| Battas, O | 1 |
| Hakkou, F | 1 |
| Tazi, A | 1 |
| O'Connell, CW | 1 |
| Sadler, CA | 1 |
| Tolia, VM | 1 |
| Ly, BT | 1 |
| Saitman, AM | 1 |
| Fitzgerald, RL | 1 |
| Ivanets, NN | 1 |
| Kinkulkina, MA | 1 |
| Avdeeva, TI | 1 |
| Tikhonova, YG | 1 |
| Liebrenz, M | 1 |
| Schneider, M | 1 |
| Buadze, A | 1 |
| Gehring, MT | 1 |
| Dube, A | 1 |
| Caflisch, C | 1 |
| Winther, RB | 1 |
| Bramness, JG | 1 |
| Ramirez, OA | 2 |
| Perez, MF | 1 |
| Laqueille, X | 1 |
| Launay, C | 1 |
| Dervaux, A | 1 |
| Kanit, M | 1 |
| Monti, MC | 1 |
| Almirón, RS | 1 |
| Bignante, EA | 1 |
| Ennaceur, A | 1 |
| Michalikova, S | 1 |
| van Rensburg, R | 1 |
| Chazot, PL | 1 |
| Bell, J | 2 |
| Collins, R | 1 |
| Volkova, AV | 1 |
| Kalinina, TC | 1 |
| Voronina, TA | 2 |
| Pauly, V | 1 |
| Frauger, E | 1 |
| Pradel, V | 1 |
| Nordmann, S | 1 |
| Pourcel, L | 1 |
| Natali, F | 1 |
| Sciortino, V | 1 |
| Lapeyre-Mestre, M | 1 |
| Micallef, J | 1 |
| Thirion, X | 1 |
| Jones, AW | 2 |
| Holmgren, A | 2 |
| Flynn, S | 1 |
| Rossiter, A | 1 |
| Wiley, JL | 2 |
| Bale, AS | 1 |
| Balster, RL | 2 |
| Kaminski, BJ | 1 |
| Sannerud, CA | 2 |
| Weerts, EM | 1 |
| Lamb, RJ | 5 |
| Griffiths, RR | 24 |
| McGregor, C | 1 |
| Machin, A | 1 |
| White, JM | 1 |
| BURDINE, WE | 1 |
| RICKELS, K | 3 |
| SATTES, H | 1 |
| Man, LH | 1 |
| Best, D | 1 |
| Gossop, M | 1 |
| Stillwell, G | 1 |
| Strang, J | 2 |
| Rappa, LR | 1 |
| Larose-Pierre, M | 1 |
| Payne, DR | 1 |
| Eraikhuemen, NE | 1 |
| Lanes, DM | 1 |
| Kearson, ML | 1 |
| Seidberg, BH | 1 |
| Sullivan, TH | 1 |
| Jain, R | 2 |
| Mintzer, MZ | 1 |
| Holmgren, P | 1 |
| Wilding, P | 1 |
| Heath, DA | 1 |
| Rada, P | 1 |
| Hoebel, BG | 1 |
| Vorma, H | 1 |
| Naukkarinen, HH | 1 |
| Sarna, SJ | 1 |
| Kuoppasalmi, KI | 1 |
| Elliott, L | 1 |
| Glenday, J | 1 |
| Freeman, L | 1 |
| Ajeda, D | 1 |
| Johnston, B | 1 |
| Christie, M | 1 |
| Ogston, S | 1 |
| Kurtz, SP | 1 |
| Inciardi, JA | 1 |
| Surratt, HL | 1 |
| Cottler, L | 1 |
| Lintzeris, N | 1 |
| Mitchell, TB | 1 |
| Bond, A | 1 |
| Nestor, L | 1 |
| de Wit, H | 6 |
| Vicini, L | 1 |
| Haig, GM | 1 |
| Hunt, T | 1 |
| Feltner, D | 1 |
| Voshaar, RC | 1 |
| Gorgels, WJ | 1 |
| Mol, AJ | 1 |
| van Balkom, AJ | 1 |
| Mulder, J | 1 |
| van de Lisdonk, EH | 1 |
| Breteler, MH | 1 |
| Zitman, FG | 1 |
| Stemmelin, J | 1 |
| Cohen, C | 1 |
| Terranova, JP | 1 |
| Lopez-Grancha, M | 1 |
| Pichat, P | 1 |
| Bergis, O | 1 |
| Decobert, M | 1 |
| Santucci, V | 1 |
| Françon, D | 1 |
| Alonso, R | 1 |
| Stahl, SM | 1 |
| Keane, P | 1 |
| Avenet, P | 1 |
| Scatton, B | 1 |
| le Fur, G | 1 |
| Griebel, G | 1 |
| Ribeiro, CS | 1 |
| Azevedo, RC | 1 |
| Silva, VF | 1 |
| Botega, NJ | 1 |
| Listos, J | 1 |
| Talarek, S | 1 |
| Fidecka, S | 1 |
| Chang, RS | 1 |
| Tse, AC | 1 |
| Mak, W | 1 |
| Cheung, RT | 1 |
| Ho, SL | 1 |
| Glatt, MM | 2 |
| Laughren, TP | 1 |
| Cohen, ES | 1 |
| Holman, RC | 1 |
| Kaneto, H | 4 |
| Rosser, WW | 1 |
| Cole, JO | 4 |
| Orzack, MH | 4 |
| Beake, B | 2 |
| Bird, M | 2 |
| Bar-Tal, Y | 1 |
| González, ER | 1 |
| MacKinnon, GL | 1 |
| Parker, WA | 1 |
| Greenblatt, DJ | 6 |
| Shader, RI | 4 |
| Abernethy, DR | 1 |
| Acuda, SW | 2 |
| McNicholas, LF | 5 |
| Martin, WR | 10 |
| Cherian, S | 2 |
| Geller, I | 1 |
| Hartmann, RJ | 1 |
| Mendez, V | 1 |
| Gause, EM | 1 |
| Uhlenhuth, EH | 7 |
| Pinsker, H | 1 |
| Suljaga-Petchel, K | 1 |
| Ator, NA | 4 |
| Lukas, SE | 3 |
| Brady, JV | 3 |
| Woods, JH | 1 |
| Hienz, RD | 2 |
| Bigelow, GE | 11 |
| Emurian, HH | 1 |
| Nellis, MJ | 1 |
| Ray, RL | 1 |
| Pearlson, GD | 1 |
| Rizzo, F | 1 |
| Fuchs, V | 1 |
| Burbes, E | 1 |
| Coper, H | 1 |
| Stadler, R | 1 |
| Orfanos, CE | 1 |
| Immel, C | 1 |
| Foltz, RL | 1 |
| Fentiman, AF | 1 |
| Foltz, RB | 1 |
| Cimbura, G | 1 |
| Lucas, DM | 1 |
| Bennett, RC | 1 |
| Warren, RA | 1 |
| Simpson, HM | 1 |
| Yanagita, T | 6 |
| Kato, S | 2 |
| deWit, H | 1 |
| McCracken, S | 1 |
| Leifer, ED | 1 |
| Goldman, J | 1 |
| Finnegan, LP | 3 |
| Harrison, M | 1 |
| Busto, U | 6 |
| Naranjo, CA | 3 |
| Kaplan, HL | 3 |
| Sellers, EM | 7 |
| Emmett-Oglesby, MW | 3 |
| Spencer, DG | 1 |
| Lewis, MW | 1 |
| Lal, H | 2 |
| Tennant, FS | 3 |
| Rawson, RA | 1 |
| Cohen, A | 1 |
| Tarver, A | 1 |
| Clabough, D | 1 |
| Michael, H | 1 |
| Leifer, B | 1 |
| Desai, S | 1 |
| McLeod, DR | 3 |
| Liebson, IA | 5 |
| Roache, JD | 5 |
| Rhodes, PJ | 1 |
| Rhodes, RS | 1 |
| McCurdy, HH | 1 |
| Pumphrey, EA | 1 |
| Preston, KL | 1 |
| Stitzer, ML | 4 |
| Kaminer, Y | 1 |
| Modai, I | 1 |
| Resnick, RB | 1 |
| Resnick, EB | 1 |
| Yoshimura, K | 2 |
| Horiuchi, M | 1 |
| Inoue, Y | 1 |
| Yamamoto, K | 2 |
| Tammelleo, AD | 1 |
| Ryser, PE | 2 |
| Jaffe, JH | 1 |
| Ciraulo, DA | 3 |
| Nies, A | 1 |
| Dixon, RB | 1 |
| Monroe, LL | 1 |
| Kilwein, JH | 1 |
| Hargreaves, WA | 1 |
| Tyler, J | 1 |
| Weinberg, JA | 1 |
| Sorensen, JL | 1 |
| Benowitz, N | 1 |
| Nowowieski, P | 1 |
| Brooker, AE | 1 |
| Wiens, AN | 1 |
| Wiens, DA | 1 |
| Gay, GR | 1 |
| Svensson, E | 1 |
| Persson, LO | 1 |
| Sjöberg, L | 1 |
| Hollister, LE | 4 |
| Conley, FK | 1 |
| Britt, RH | 1 |
| Shuer, L | 1 |
| Cumin, R | 1 |
| Bonetti, EP | 1 |
| Scherschlicht, R | 1 |
| Haefely, WE | 2 |
| Ionescu-Pioggia, M | 1 |
| Beake, BJ | 1 |
| Bird, MP | 1 |
| Lobel, M | 1 |
| Jasinski, DR | 3 |
| Haertzen, CA | 1 |
| Henningfield, JE | 1 |
| Johnson, RE | 2 |
| Makhzoumi, HM | 1 |
| Miyasato, K | 2 |
| Healey, ML | 1 |
| Pickens, RW | 1 |
| Liebson, I | 7 |
| Ramesar, S | 1 |
| McCall, M | 1 |
| Valdman, AV | 1 |
| Zvartau, EE | 1 |
| Winokur, A | 1 |
| Snyder, PJ | 1 |
| Schatz, NJ | 1 |
| Petursson, H | 2 |
| Lader, MH | 2 |
| Cohen, MS | 1 |
| Jack, RA | 1 |
| Herrington, RE | 1 |
| Benzer, DG | 1 |
| Jacobson, GR | 1 |
| Hawkins, MK | 1 |
| Jensen, HH | 1 |
| Poulsen, JC | 1 |
| Kliner, DJ | 1 |
| Pickens, R | 1 |
| Lessenger, JE | 1 |
| Kulik, AV | 1 |
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| Dillman, CE | 1 |
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| McLellan, AT | 1 |
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| Balmer, R | 1 |
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| Jing, X | 6 |
| Wala, EP | 10 |
| Sloan, JW | 12 |
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| Jenck, F | 3 |
| Hershberg, PI | 1 |
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| Sanger, DJ | 1 |
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| Mizoguchi, H | 4 |
| Suzuki, T | 8 |
| Misawa, M | 6 |
| Kulkarni, SK | 1 |
| Sharma, K | 1 |
| Löscher, W | 3 |
| Auta, J | 2 |
| Giusti, P | 1 |
| Guidotti, A | 2 |
| Costa, E | 2 |
| Johnson, FY | 1 |
| Chutuape, MA | 1 |
| Sribanditmongkol, P | 1 |
| Sheu, MJ | 1 |
| Tejwani, GA | 1 |
| Steppuhn, KG | 2 |
| Schneider, HH | 1 |
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| Stephens, DN | 1 |
| Robertson, M | 1 |
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| Tsuda, M | 1 |
| Yoshiike, M | 2 |
| Zawertailo, L | 1 |
| Tata, PR | 1 |
| Rollings, J | 1 |
| Collins, M | 1 |
| Pickering, A | 1 |
| Jacobson, RR | 1 |
| DuPont, RL | 1 |
| Kosten, TR | 1 |
| Romach, MK | 1 |
| Woody, GE | 2 |
| Sullivan, JT | 2 |
| García Márquez, P | 1 |
| Baz Alonso, MJ | 1 |
| Motegi, H | 2 |
| Awano, H | 1 |
| Toki, S | 2 |
| Saito, T | 2 |
| Nabeshima, A | 1 |
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| Watanabe, M | 1 |
| Takahata, N | 2 |
| Hänselmann, H | 1 |
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| Rundfeldt, C | 1 |
| Hönack, D | 2 |
| Ebert, U | 1 |
| Inui, Y | 1 |
| Yamamoto, M | 1 |
| Awasaki, Y | 1 |
| Nishida, N | 1 |
| Künstler, U | 1 |
| Garretty, DJ | 1 |
| Wolff, K | 1 |
| Hay, AW | 1 |
| Raistrick, D | 1 |
| Barnhill, JG | 1 |
| Ciraulo, AM | 1 |
| Sarid-Segal, O | 1 |
| Knapp, C | 1 |
| Pérez de los Cobos, J | 1 |
| Trujols, J | 1 |
| Ribalta, E | 1 |
| Casas, M | 1 |
| File, SE | 2 |
| Fernandes, C | 1 |
| Nakamura-Palacios, EM | 1 |
| Roelke, CE | 1 |
| Jiang, Z | 1 |
| Guo, H | 1 |
| Zhu, Z | 1 |
| Li, Z | 1 |
| Wu, Y | 1 |
| Knuepfer, MM | 1 |
| Gan, Q | 1 |
| Pratt, JA | 1 |
| Brett, RR | 1 |
| Laurie, DJ | 1 |
| Pieri, L | 2 |
| Garibova, TL | 1 |
| Val'dman, EA | 1 |
| Kraĭneva, VA | 1 |
| Vieira Filho, AH | 1 |
| Kippin, TE | 1 |
| Kalynchuk, LE | 1 |
| St Denis, M | 1 |
| Pinel, JP | 1 |
| Bowen, SE | 1 |
| Jones, HE | 1 |
| Kuribara, H | 1 |
| Stavinoha, WB | 1 |
| Maruyama, Y | 1 |
| Wooddell, WJ | 1 |
| Petry, NM | 2 |
| Bickel, WK | 1 |
| Korkmaz, S | 1 |
| Wahlström, G | 1 |
| Matheson, C | 1 |
| Bond, CM | 1 |
| Hickey, F | 1 |
| Holtman, JR | 2 |
| Easterling, KW | 1 |
| Plovnick, RM | 1 |
| Holtzman, SG | 1 |
| Charney, DA | 1 |
| Paraherakis, AM | 1 |
| Gill, KJ | 1 |
| Leri, F | 1 |
| Franklin, KB | 1 |
| Addolorato, G | 1 |
| Caputo, F | 1 |
| Capristo, E | 1 |
| Gasbarrini, G | 1 |
| David, V | 1 |
| Gold, LH | 1 |
| Koob, GF | 1 |
| Cazala, P | 1 |
| Izzo, E | 1 |
| Impagnatiello, F | 1 |
| Pesold, C | 1 |
| Smith-Kielland, A | 1 |
| Skuterud, B | 1 |
| Olsen, KM | 1 |
| Mørland, J | 2 |
| Smith, MA | 1 |
| Stoops, WW | 1 |
| Kahlert, I | 1 |
| Brüne, M | 1 |
| Singh, RK | 1 |
| Ray, R | 1 |
| Gupta, YK | 1 |
| Follesa, P | 1 |
| Cagetti, E | 1 |
| Mancuso, L | 1 |
| Biggio, F | 1 |
| Manca, A | 1 |
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| Bouton, ME | 1 |
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| Schmid, TE | 1 |
| Baumgartner, A | 1 |
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| Wahl, KC | 1 |
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| Kirkpatrick, B | 1 |
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| Moerck, HJ | 1 |
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| Kissin, B | 1 |
| Bissell, LC | 1 |
| Fink, M | 1 |
| Anderson, O | 1 |
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| Finlayson, RE | 1 |
| Pakes, GE | 2 |
| Burstein, Y | 1 |
| Giardina, PJ | 1 |
| Rausen, AR | 1 |
| Kandall, SR | 3 |
| Siljestrom, K | 1 |
| Peterson, CM | 1 |
| Bigelow, G | 2 |
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| Lippiett, P | 1 |
| Park, J | 1 |
| Barber, DN | 1 |
| Haddad, LM | 1 |
| Livni, N | 1 |
| Steigbuegel, D | 1 |
| Levu, IS | 1 |
| Kryspin-Exner, K | 5 |
| Demel, I | 1 |
| Raskind, M | 1 |
| Bradford, T | 1 |
| Vaag, UH | 2 |
| Sardemann, H | 1 |
| Friis-Hansen, B | 1 |
| Janssen, F | 1 |
| Takahashi, M | 1 |
| Koide, M | 1 |
| Yanaura, S | 4 |
| Tagashira, E | 2 |
| Tagashire, E | 1 |
| Kron, RE | 1 |
| Litt, M | 1 |
| Haskell, D | 1 |
| O'Brien, CP | 1 |
| Greenstein, R | 1 |
| Glauser, FL | 1 |
| Smith, WR | 1 |
| Bant, W | 1 |
| Griffiths, R | 1 |
| Denber, HC | 1 |
| Maletzky, BM | 1 |
| Klotter, J | 1 |
| Blinick, G | 1 |
| Wallach, RC | 1 |
| Jerez, E | 1 |
| Ackerman, BD | 1 |
| Martinez, JA | 1 |
| Fargeas, MJ | 1 |
| Bueno, L | 1 |
| Tattersall, ML | 1 |
| Hallstrom, C | 2 |
| Busto, UE | 1 |
| Lu, MS | 1 |
| Yoshii, T | 2 |
| Pugh, SL | 1 |
| Boone, MS | 1 |
| Holton, A | 2 |
| Riley, P | 1 |
| Tyrer, P | 4 |
| Phillips, TJ | 1 |
| Burkhart-Kasch, S | 1 |
| Gwiazdon, CC | 1 |
| Crabbe, JC | 2 |
| Allen, M | 1 |
| Cook, JM | 1 |
| Murphy, SM | 1 |
| Sheehan, MF | 1 |
| Sheehan, DV | 1 |
| Torres, A | 1 |
| Coppola, A | 1 |
| Francis, E | 1 |
| Wala, E | 2 |
| Dickey, KM | 1 |
| Garcia-Borreguero, D | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of N-acetylcysteine (NAC) on Treatment of Alcohol and Cocaine Use Disorders: A Double-Blind Randomized Controlled Trial.[NCT03018236] | Phase 4 | 100 participants (Anticipated) | Interventional | 2017-01-31 | Recruiting | ||
| Implementation Strategies Aimed at a Simple Patient-directed Intervention to Reduce Long-term Use of Benzodiazepines in Dutch Community Pharmacies[NCT00268775] | 20,000 participants | Interventional | 2005-11-30 | Completed | |||
| Continuing Care Following Drug Abuse Treatment: Linkage With Primary Care[NCT01621711] | 504 participants (Actual) | Interventional | 2011-03-31 | Active, not recruiting | |||
| Baclofen in Chronic Pelvic Pain, a Randomized, Double-Blind, Placebo Controlled Trial[NCT05968937] | Phase 2 | 44 participants (Anticipated) | Interventional | 2024-01-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
30 reviews available for diazepam and Chemical Dependence
| Article | Year |
|---|---|
New approach for detoxification of patients dependent on benzodiazepines and Z-drugs for reduction of psychogenic complications.
Topics: Benzodiazepines; Diazepam; Drug Administration Schedule; Humans; Inactivation, Metabolic; Substance | 2019 |
Treatment of Benzodiazepine Dependence.
Topics: Anti-Anxiety Agents; Benzodiazepines; Diagnosis, Differential; Diazepam; Humans; Hypnotics and Sedat | 2017 |
Tianeptine Abuse and Dependence: Case Report and Literature Review.
Topics: Adult; Aged; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Diazepam; Female; Gabapentin; Hu | 2018 |
The plastic phenomenon underlying the associative processes in the addictive properties of diazepam and other psychoactive drugs.
Topics: Animals; Behavior, Addictive; Brain; Diazepam; Drug Tolerance; Humans; Psychotropic Drugs; Substance | 2009 |
[Abuse of alcohol and benzodiazepine during substitution therapy in heroin addicts: a review of the literature].
Topics: Adolescent; Adult; Alcoholism; Benzodiazepines; Buprenorphine; Clonazepam; Clorazepate Dipotassium; | 2009 |
Benzodiazepine withdrawal syndrome: a literature review and evaluation.
Topics: Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Dose-Response Relationship, Drug; Humans; Lorazepam | 1982 |
Drug therapy. Current status of benzodiazepines.
Topics: Alcoholic Beverages; Alcoholism; Anesthetics; Anti-Anxiety Agents; Anxiety; Benzodiazepines; Bone Di | 1983 |
GC/MS assays for abused drugs in body fluids.
Topics: Amphetamines; Chromatography, Gas; Cocaine; Diazepam; Dronabinol; Humans; Mass Spectrometry; Mescali | 1980 |
Clinical management of acute and chronic cocaine poisoning.
Topics: Brain; California; Cardiovascular System; Chemical Phenomena; Chemistry; Cocaine; Diazepam; Humans; | 1982 |
Benzodiazepine dependence.
Topics: Animals; Benzodiazepines; Chlordiazepoxide; Diazepam; Disease Models, Animal; Dose-Response Relation | 1981 |
Drug abuse in pregnancy: fetal ad neonatal effects.
Topics: Alcoholism; Birth Weight; Chlorpromazine; Diazepam; Female; Fetus; Humans; Infant, Newborn; Infant, | 1982 |
Approach to the dizzy patient.
Topics: Anxiety Disorders; Brain Diseases; Diazepam; Dizziness; Heart Diseases; Humans; Meclizine; Meniere D | 1994 |
Abecarnil shows reduced tolerance development and dependence potential in comparison to diazepam: animal studies.
Topics: Animals; Anti-Anxiety Agents; Carbolines; Diazepam; Dogs; Drug Tolerance; Substance-Related Disorder | 1993 |
Alprazolam and benzodiazepine dependence.
Topics: Adult; Alcoholism; Alprazolam; Benzodiazepines; Comorbidity; Diazepam; Female; Humans; Incidence; Ma | 1993 |
Clonazepam. A review of a new anticonvulsant drug.
Topics: Adult; Benzodiazepinones; Brain; Chemical Phenomena; Chemistry; Child; Clonazepam; Diazepam; Drug To | 1976 |
Alprazolam and diazepam: addiction potential.
Topics: Alprazolam; Diazepam; Humans; Risk Factors; Substance Withdrawal Syndrome; Substance-Related Disorde | 1991 |
Neurologic complications of cocaine abuse.
Topics: Cocaine; Diazepam; Humans; Nervous System Diseases; Seizures; Substance-Related Disorders | 1990 |
Diazepam (Valium): its dependency liability.
Topics: Arousal; Diazepam; Drug Tolerance; Humans; Substance Withdrawal Syndrome; Substance-Related Disorder | 1990 |
Time course for development of benzodiazepine tolerance and physical dependence.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Drug Tolerance; Flumazenil; Flurazepam; H | 1985 |
Buspirone. A preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Buspirone; Depression; Diazepam; Drug Administration | 1986 |
Withdrawal and detoxification from benzodiazepine dependence: a potential role for clonazepam.
Topics: Adolescent; Adult; Aged; Alprazolam; Anti-Anxiety Agents; Clonazepam; Diazepam; Drug Tolerance; Huma | 1987 |
Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo.
Topics: Adolescent; Adult; Alprazolam; Arousal; Diazepam; Euphoria; Female; Humans; Lorazepam; Male; Methaqu | 1988 |
Factors affecting the drinking driver.
Topics: Accidents, Traffic; Alcoholic Intoxication; Automobile Driving; Diazepam; Ethanol; Humans; Marijuana | 1987 |
Benzodiazepines in general practice: time for a decision.
Topics: Benzodiazepines; Counseling; Diazepam; Family Practice; Humans; Mood Disorders; Substance-Related Di | 1985 |
Drug therapy. Benzodiazepines (second of two parts).
Topics: Affective Symptoms; Alcoholism; Analgesia; Anesthesia, General; Anesthesia, Obstetrical; Anti-Anxiet | 1974 |
Use of beta-adrenergic receptor blocking drugs in psychiatry.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Alcoholism; Anxiety; Chlordiazepoxide; Di | 1974 |
Sedatives and tranquilizers.
Topics: Anxiety; Barbiturates; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; Humans; Hypnotics and S | 1972 |
The benzodiazepines.
Topics: Alcoholism; Anesthesia; Animals; Antidepressive Agents; Benzazepines; Diazepam; Epilepsy; Heart Dise | 1973 |
[Misuse of benzodiazepine derivatives. A review, with special reference to Norwegian data].
Topics: Chlordiazepoxide; Diazepam; Humans; Norway; Oxazepam; Substance-Related Disorders; Tranquilizing Age | 1971 |
Pharmacology of benzodiazepines: laboratory and clinical correlations.
Topics: Aggression; Alcoholism; Animals; Anticonvulsants; Anxiety; Autonomic Nervous System; Avoidance Learn | 1967 |
51 trials available for diazepam and Chemical Dependence
| Article | Year |
|---|---|
Discontinuation of chronic benzodiazepine use in primary care: a nonrandomized intervention.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Female; | 2022 |
In-patient benzodiazepine withdrawal: comparison of fixed and symptom-triggered taper methods.
Topics: Adult; Benzodiazepines; Diazepam; Female; Follow-Up Studies; GABA Modulators; Humans; Male; Outcome | 2003 |
Flumazenil-precipitated withdrawal in healthy volunteers following repeated diazepam exposure.
Topics: Administration, Oral; Adult; Blood Pressure; Diazepam; Dose-Response Relationship, Drug; Drug Admini | 2005 |
Predictors of benzodiazepine discontinuation in subjects manifesting complicated dependence.
Topics: Adult; Alcoholism; Anticonvulsants; Benzodiazepines; Diagnostic and Statistical Manual of Mental Dis | 2005 |
Reducing diazepam prescribing for illicit drug users: a randomised control study.
Topics: Adult; Anticonvulsants; Anxiety; Depression; Diazepam; Drug Prescriptions; Follow-Up Studies; Humans | 2005 |
Interactions on mixing diazepam with methadone or buprenorphine in maintenance patients.
Topics: Adolescent; Adult; Buprenorphine; Diazepam; Double-Blind Method; Drug Interactions; Female; Heroin D | 2006 |
Evaluation of the abuse potential of pagoclone, a partial GABAA agonist.
Topics: Adolescent; Adult; Affect; Blood Pressure; Diazepam; Double-Blind Method; Euphoria; Female; GABA Ago | 2006 |
Predictors of long-term benzodiazepine abstinence in participants of a randomized controlled benzodiazepine withdrawal program.
Topics: Aged; Alcohol Drinking; Anti-Anxiety Agents; Benzodiazepines; Cognitive Behavioral Therapy; Combined | 2006 |
Assessment of the abuse liability of buspirone in recreational sedative users.
Topics: Anti-Anxiety Agents; Buspirone; Diazepam; Dose-Response Relationship, Drug; Emotions; Euphoria; Fema | 1982 |
Where are all the tranquilizer junkies?
Topics: Anti-Anxiety Agents; Clinical Trials as Topic; Diazepam; Double-Blind Method; Humans; Lorazepam; Sub | 1983 |
The dependence potential of benzodiazepines.
Topics: Adult; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Lorazepam; M | 1984 |
Relative abuse liability of diazepam and oxazepam: behavioral and subjective dose effects.
Topics: Adult; Behavior; Cognition; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Emotions; Hu | 1984 |
Mood effects of diazepam and caffeine.
Topics: Adult; Caffeine; Diazepam; Discrimination, Psychological; Emotions; Extraversion, Psychological; Fem | 1980 |
Drug preference and mood in humans: diazepam.
Topics: Choice Behavior; Dextroamphetamine; Diazepam; Emotions; Female; Humans; Male; Placebos; Substance-Re | 1980 |
A comparison of some subjective effects of prazepam, diazepam, and placebo.
Topics: Adolescent; Adult; Diazepam; Female; Humans; Male; Placebos; Prazepam; Risk; Substance-Related Disor | 1982 |
Differential effects of diazepam and pentobarbital on mood and behavior.
Topics: Adolescent; Adult; Diazepam; Dose-Response Relationship, Drug; Emotions; Hostility; Humans; Hypnotic | 1983 |
Withdrawal reaction from long-term, low-dosage administration of diazepam. A double-blind, placebo-controlled case study.
Topics: Adult; Anxiety; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Norda | 1980 |
Sedative-hypnotic tolerance testing and withdrawal comparing diazepam to barbiturates.
Topics: Adult; Barbiturates; Diazepam; Drug Tolerance; Female; Humans; Male; Middle Aged; Substance Withdraw | 1981 |
Differential acute psychomotor and cognitive effects of diazepam on long-term benzodiazepine users.
Topics: Adult; Anxiety Disorders; Cognition; Depressive Disorder; Diazepam; Dose-Response Relationship, Drug | 1994 |
Relationship between subjective effects and drug preferences: ethanol and diazepam.
Topics: Adult; Affect; Alcohol Drinking; Alcoholic Intoxication; Arousal; Choice Behavior; Diazepam; Dose-Re | 1994 |
Pharmacologic effects and abuse liability of bretazenil, diazepam, and alprazolam in humans.
Topics: Adult; Alprazolam; Analysis of Variance; Benzodiazepinones; Diazepam; Dose-Response Relationship, Dr | 1994 |
Single-dose pharmacodynamics of diazepam and pentobarbital in substance abusers.
Topics: Adult; Behavior; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Midd | 1993 |
Alterations in pharmacodynamics of anxiolytics in abstinent alcoholic men: subjective responses, abuse liability, and electroencephalographic effects of alprazolam, diazepam, and buspirone.
Topics: Adult; Affect; Alcoholism; Alprazolam; Anti-Anxiety Agents; Buspirone; Diazepam; Electrocardiography | 1997 |
Cocaine use immediately prior to entry in an inpatient heroin detoxification unit as a predictor of discharges against medical advice.
Topics: Analgesics, Opioid; Analysis of Variance; Antiemetics; Cocaine; Counseling; Dextropropoxyphene; Diaz | 1997 |
Stressful reactions and panic attacks induced by flumazenil in chronic benzodiazepine users.
Topics: Adult; Anti-Anxiety Agents; Arousal; Diazepam; Double-Blind Method; Female; Flumazenil; GABA Modulat | 1998 |
Urinary excretion of diazepam metabolites in healthy volunteers and drug users.
Topics: Adult; Anti-Anxiety Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Creatinine; D | 2001 |
Abuse liability of diazepam through different routes.
Topics: Adult; Diazepam; Humans; Male; Middle Aged; Pain Measurement; Substance-Related Disorders | 2001 |
Human drug self-administration: double-blind comparison of pentobarbital, diazepam, chlorpromazine and placebo.
Topics: Adult; Chlorpromazine; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Adminis | 1979 |
Reducing benzodiazepine self-administration with contingent reinforcement.
Topics: Adult; Diazepam; Humans; Methadone; Opioid-Related Disorders; Self Administration; Substance-Related | 1979 |
The use of tranquilizers in the treatment of mixed drug abuse.
Topics: Adult; Alcoholism; Analgesics; Barbiturates; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; F | 1975 |
Abuse liability of bretazenil and other partial agonists.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Double-Blind Method; Humans; Ma | 1992 |
A double-blind comparison of the effects of gradual withdrawal of lorazepam, diazepam and bromazepam in benzodiazepine dependence.
Topics: Adult; Anti-Anxiety Agents; Bromazepam; Diazepam; Dose-Response Relationship, Drug; Double-Blind Met | 1991 |
Diazepam preference in males with and without an alcoholic first-degree relative.
Topics: Adult; Affect; Alcoholism; Analysis of Variance; Diazepam; Humans; Male; Sleep; Substance-Related Di | 1991 |
Preference for alprazolam as opposed to diazepam in benzodiazepine-dependent psychiatric inpatients.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Diazepam; Double-Blind Method; Female; Humans; Male; Middle | 1990 |
Long-term therapeutic use of benzodiazepines. I. Effects of abrupt discontinuation.
Topics: Ambulatory Care; Anxiety Disorders; Benzodiazepines; Dependent Personality Disorder; Depressive Diso | 1990 |
A double-blind placebo-controlled study of buspirone in diazepam withdrawal in chronic benzodiazepine users.
Topics: Adult; Buspirone; Diazepam; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Stu | 1990 |
Diazepam and triazolam self-administration in sedative abusers: concordance of subject ratings, performance and drug self-administration.
Topics: Adult; Diazepam; Double-Blind Method; Humans; Hypnotics and Sedatives; Male; Middle Aged; Psychomoto | 1989 |
Cognitive-behavioural treatment for benzodiazepine dependence.
Topics: Cognition; Diazepam; Female; Follow-Up Studies; Humans; Lorazepam; Male; Substance-Related Disorders | 1986 |
Cognitive-behavioural treatment for benzodiazepine dependence: a comparison of gradual versus abrupt cessation of drug intake.
Topics: Adult; Anti-Anxiety Agents; Behavior Therapy; Cognition; Combined Modality Therapy; Diazepam; Female | 1987 |
Potential for abuse of alprazolam.
Topics: Alprazolam; Clinical Trials as Topic; Diazepam; Double-Blind Method; Humans; Lorazepam; Methaqualone | 1988 |
Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo.
Topics: Adolescent; Adult; Alprazolam; Arousal; Diazepam; Euphoria; Female; Humans; Lorazepam; Male; Methaqu | 1988 |
Drug deprivation and reinforcement by diazepam in a dependent population.
Topics: Adult; Diazepam; Female; Humans; Male; Middle Aged; Reinforcement, Psychology; Self Administration; | 1987 |
Relative abuse liability of lorazepam and diazepam: an evaluation in 'recreational' drug users.
Topics: Adult; Cognition Disorders; Diazepam; Double-Blind Method; Humans; Lorazepam; Male; Psychomotor Diso | 1988 |
Effects of tizanidine in healthy volunteers: double-blind study compared with diazepam and a placebo.
Topics: Adult; Blood Pressure; Clonidine; Diazepam; Double-Blind Method; Heart Rate; Humans; Male; Placebos; | 1988 |
Lack of preference for diazepam in anxious volunteers.
Topics: Adult; Amphetamine; Anxiety Disorders; Attitude to Health; Choice Behavior; Diazepam; Female; Humans | 1986 |
Repeated administration of diazepam and triazolam to subjects with histories of drug abuse.
Topics: Adult; Diazepam; Dose-Response Relationship, Drug; Drug Tolerance; Humans; Male; Psychomotor Perform | 1986 |
Investigation of the abuse liability of buspirone in alcohol-dependent patients.
Topics: Administration, Oral; Adult; Alcoholism; Appetite; Buspirone; Diazepam; Euphoria; Humans; Male; Midd | 1986 |
Sedatives and tranquilizers.
Topics: Anxiety; Barbiturates; Chlordiazepoxide; Clinical Trials as Topic; Diazepam; Humans; Hypnotics and S | 1972 |
Effects of different rates of absorption of two benzodiazepins on subjective and objective parameters. Significance for clinical use and risk of abuse.
Topics: Absorption; Anxiety; Diazepam; Female; Hand; Humans; Male; Oxazepam; Placebos; Pulse; Reaction Time; | 1974 |
Factors leading to dependence on hypnotic drugs.
Topics: Amobarbital; Benzazepines; Diazepam; Family Practice; Female; Glutethimide; Humans; Hypnotics and Se | 1972 |
Meprobamate: a study of irrational drug use.
Topics: Agranulocytosis; Anemia, Aplastic; Anxiety; Chlordiazepoxide; Diazepam; Humans; Meprobamate; Neuroti | 1971 |
391 other studies available for diazepam and Chemical Dependence
| Article | Year |
|---|---|
Chemistry and pharmacology of the non-benzodiazepine anxiolytic enciprazine and related compounds.
Topics: Aggression; Animals; Anti-Anxiety Agents; Behavior, Animal; Chemical Phenomena; Chemistry; Explorato | 1990 |
3-Phenyl-substituted imidazo[1,5-alpha]quinoxalin-4-ones and imidazo[1,5-alpha]quinoxaline ureas that have high affinity at the GABAA/benzodiazepine receptor complex.
Topics: Animals; Anticonvulsants; Benzodiazepines; Cell Membrane; Cerebral Cortex; Drug Synergism; Ethanol; | 1996 |
Delayed crises following benzodiazepine withdrawal: deficient adaptive mechanisms or simple pharmacokinetics? Detoxification assisted by serum-benzodiazepine elimination tracking.
Topics: Age Factors; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Sex | 2022 |
Convulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA, 5F-AB-PINACA, 5F-ADB-PINACA and JWH-018 do not elicit electroencephalographic (EEG) seizures in male mice.
Topics: Animals; Benzodiazepines; Cannabinoid Receptor Agonists; Cannabinoids; Convulsants; Diazepam; Electr | 2022 |
Use of a long-acting substitute in detoxification from benzodiazepines: safety (accumulation) problems and proposed mitigation procedure.
Topics: Anti-Anxiety Agents; Benzodiazepines; Diazepam; Humans; Hypnotics and Sedatives; Male; Substance-Rel | 2022 |
Drug prescriptions preceding opioid-related deaths-a register study in forensic autopsy patients.
Topics: Alprazolam; Analgesics, Opioid; Autopsy; Diazepam; Drug Overdose; Drug Prescriptions; Humans; Opioid | 2023 |
Misuse of prescription medicines is as prevalent as the use of recreational drugs and novel psychoactive substances in Singapore: an unrecognised public health issue?
Topics: Codeine; Diazepam; Humans; Illicit Drugs; Prescription Drugs; Prescriptions; Public Health; Singapor | 2022 |
Severe Benzodiazepine Use Disorder in a 16-Year-Old Adolescent: A Rapid and Safe Inpatient Taper.
Topics: Adolescent; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; GABA Modulators; Hospitaliz | 2021 |
New benzodiazepine and Z-hypnotic users and disability pension: an eight-year nationwide observational follow-up study.
Topics: Adult; Benzodiazepines; Clonazepam; Diazepam; Disabled Persons; Drug Prescriptions; Female; Follow-U | 2017 |
Assessment of the Availability, Cost, and Motivations for Use over Time of the New Psychoactive Substances-Benzodiazepines Diclazepam, Flubromazepam, and Pyrazolam-in the UK.
Topics: Anti-Anxiety Agents; Benzodiazepines; Central Nervous System Stimulants; Designer Drugs; Diazepam; D | 2018 |
Considerations for the use of a loading dose of diazepam for the treatment of benzodiazepine dependence.
Topics: Alcoholism; Benzodiazepines; Diazepam; Humans; Substance Withdrawal Syndrome; Substance-Related Diso | 2018 |
Alleviation of diazepam-induced conditioned place preference and its withdrawal-associated neurobehavioral deficits following pre-exposure to enriched environment in rats.
Topics: Animals; Conditioning, Operant; Diazepam; Environment; Locomotion; Male; Maze Learning; Rats; Rats, | 2019 |
Drug addiction is associated with leukocyte telomere length.
Topics: Adult; Analgesics, Opioid; Cohort Studies; Diazepam; Female; Heroin; Humans; Hypnotics and Sedatives | 2013 |
Concentrations of drugs determined in blood samples collected from suspected drugged drivers in England and Wales.
Topics: Adolescent; Adult; Amphetamine; Automobile Driving; Central Nervous System Depressants; Chromatograp | 2013 |
Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Behavior, Animal; Diazepam; Female; Humans; | 2013 |
Effects of chronic mild stress on the development of drug dependence in rats.
Topics: Animals; Chronic Disease; Citalopram; Depressive Disorder; Diazepam; Disease Models, Animal; Flumaze | 2014 |
A mixed MDPV and benzodiazepine intoxication in a chronic drug abuser: determination of MDPV metabolites by LC-HRMS and discussion of the case.
Topics: Adult; Alprazolam; Benzodiazepines; Benzodioxoles; Chlordiazepoxide; Chromatography, Liquid; Diazepa | 2014 |
Contribution of in utero drug exposure when interpreting hair results in young children.
Topics: Amitriptyline; Bromazepam; Cannabinoids; Diazepam; Diphenhydramine; Female; Forensic Toxicology; Hai | 2015 |
Detection Times of Diazepam, Clonazepam, and Alprazolam in Oral Fluid Collected From Patients Admitted to Detoxification, After High and Repeated Drug Intake.
Topics: Adult; Alprazolam; Chromatography, High Pressure Liquid; Clonazepam; Diazepam; Female; Humans; Male; | 2015 |
Prescribing patterns of the four most commonly used sedatives in endoscopic examination in Korea: propofol, midazolam, diazepam, and lorazepam.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diazepam; Drug Prescriptions; Drug Utilization Review; E | 2015 |
Increased use in propofol and reported patterns of adverse events among anesthetics in Korea.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Anesthetics, Intravenous; Child; C | 2015 |
Prenatal stress alters sensitivity to benzodiazepines in adult rats.
Topics: Animals; Anti-Anxiety Agents; Conditioning, Classical; Diazepam; Female; Male; Maternal Exposure; Ma | 2015 |
Overdose of etizolam: the abuse and rise of a benzodiazepine analog.
Topics: Adult; Diazepam; Drug Overdose; Emergency Service, Hospital; Humans; Male; Substance-Related Disorde | 2015 |
[Remote consequences of the long-term uncontrollable consumption of anxiolytics and hypnotics in elderly: a problem of drug dependence].
Topics: Aged; Aged, 80 and over; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Female; Humans; Hypnotics a | 2015 |
Attitudes towards a maintenance (-agonist) treatment approach in high-dose benzodiazepine-dependent patients: a qualitative study.
Topics: Adult; Aged; Attitude; Benzodiazepines; Crime; Delayed-Action Preparations; Diazepam; Female; Humans | 2016 |
A 5-year follow-up study of users of benzodiazepine: starting with diazepam versus oxazepam.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Depression; Diazepam; Dose-Response Relationship, Drug; Drug Pr | 2016 |
[Prescription shopping of addictive drugs in Norway].
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Carisoprodol; Codeine; Diazepam; Drug Prescriptions; Family | 2009 |
Changes in hippocampal arc protein expression and synaptic plasticity by the presentation of contextual cues linked to drug experience.
Topics: Animals; Cues; Cytoskeletal Proteins; Diazepam; Electrophysiology; Hippocampus; Immunohistochemistry | 2010 |
Tolerance, sensitization and dependence to diazepam in Balb/c mice exposed to a novel open space anxiety test.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Animal; Dose-Response Relationship, | 2010 |
Gamma-butyrolactone (GBL) dependence and withdrawal.
Topics: 4-Butyrolactone; Adult; Ambulatory Care; Baclofen; Delirium; Diazepam; Dose-Response Relationship, D | 2011 |
[Comparative study of the interoceptive effects of afobazole and diazepam].
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Benzimidazoles; Diazepam; Male; Morpholines; Rats; | 2010 |
Monitoring of benzodiazepine diversion using a multi-indicator approach.
Topics: Benzodiazepines; Clonazepam; Cross-Sectional Studies; Data Collection; Databases, Factual; Diazepam; | 2011 |
Concentrations of zolpidem and zopiclone in venous blood samples from impaired drivers compared with femoral blood from forensic autopsies.
Topics: Adult; Aged; Automobile Driving; Azabicyclo Compounds; Central Nervous System Depressants; Chromatog | 2012 |
Chemical addiction: Daniella's decisions.
Topics: Adult; Analgesics; Decision Making; Diazepam; Drug Tolerance; Female; Humans; Medical Staff, Hospita | 2003 |
Evaluation of toluene dependence and cross-sensitization to diazepam.
Topics: Animals; Convulsants; Diazepam; Excitatory Amino Acid Agonists; Inhalation Exposure; Male; Mice; Mot | 2003 |
Physical dependence in baboons chronically treated with low and high doses of diazepam.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Papio; Substance Withdrawal S | 2003 |
DIAZEPAM IN A GENERAL PSYCHIATRIC PRACTICE.
Topics: Alcoholism; Antisocial Personality Disorder; Convulsive Therapy; Diazepam; Drug Therapy; Electroconv | 1964 |
THE ROLE OF TRANQUILIZERS IN MEDICAL PRACTICE IN THE CONTROL OF ANXIETY. IMPORTANT AND RELEVANT ASPECTS OF TRANQUILIZER THERAPY.
Topics: Anxiety; Anxiety Disorders; Barbiturates; Biomedical Research; Chlordiazepoxide; Diazepam; Drug Ther | 1964 |
[TRANQUILIZERS AND PSYCHOTONICS].
Topics: Amphetamine; Amphetamines; Chlordiazepoxide; Diazepam; Drug Therapy; Humans; Meprobamate; Methamphet | 1965 |
Relationship between prescribing and risk of opiate overdose among drug users in and out of maintenance treatment.
Topics: Adult; Alcoholic Intoxication; Benzodiazepines; Causality; Cocaine-Related Disorders; Comorbidity; C | 2004 |
Detoxification from high-dose zolpidem using diazepam.
Topics: Administration, Oral; Adult; Diazepam; Drug Administration Schedule; Drug Tolerance; Humans; Hypnoti | 2004 |
Dentists' use, misuse, abuse or dependence on mood-altering substances.
Topics: Affect; Dentists; Diazepam; Humans; Male; Nitrous Oxide; Substance-Related Disorders; Suicide; Tobac | 2004 |
Self-reported drug use and urinalysis results.
Topics: Adult; Buprenorphine; Chromatography, Gas; Chromatography, Thin Layer; Dextropropoxyphene; Diazepam; | 2004 |
High concentrations of diazepam and nordiazepam in blood of impaired drivers: association with age, gender and spectrum of other drugs present.
Topics: Adolescent; Adult; Age Distribution; Amphetamine; Anti-Anxiety Agents; Automobile Driving; Central N | 2004 |
Effect of paracetamol on uric acid determination.
Topics: Acetaminophen; Adult; Anticonvulsants; Autoanalysis; Bromides; Diazepam; Dose-Response Relationship, | 1975 |
Acetylcholine in the accumbens is decreased by diazepam and increased by benzodiazepine withdrawal: a possible mechanism for dependency.
Topics: Acetylcholine; Animals; Behavior, Animal; Benzodiazepines; Diazepam; Dopamine; Dose-Response Relatio | 2005 |
Prescription drug abuse among ecstasy users in Miami.
Topics: Adolescent; Adult; Alprazolam; Catchment Area, Health; Diazepam; Drug Prescriptions; Ethnicity; Fema | 2005 |
Stimulation of the beta3-Adrenoceptor as a novel treatment strategy for anxiety and depressive disorders.
Topics: Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Aggression; Animals; Anti-Anxiety Age | 2008 |
Chronic use of diazepam in primary healthcare centers: user profile and usage pattern.
Topics: Anti-Anxiety Agents; Anxiety Disorders; Depressive Disorder; Diazepam; Drug Utilization; Female; Hum | 2007 |
Adenosine receptor agonists attenuate the development of diazepam withdrawal-induced sensitization in mice.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A2 Receptor Agonists; Adenosine-5'-(N-ethylcarb | 2008 |
From drugs to delirium.
Topics: Adult; Anticonvulsants; Diazepam; Humans; Male; Psychomotor Performance; Status Epilepticus; Substan | 2008 |
Benzodiazepines.
Topics: Diazepam; Humans; Substance-Related Disorders | 1967 |
Maintenance treatment with benzodiazepines.
Topics: Anti-Anxiety Agents; Anxiety; Diazepam; Humans; Substance Withdrawal Syndrome; Substance-Related Dis | 1980 |
An integrated approach to iatrogenic drug abuse in a closed delivery system.
Topics: Adult; Aged; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Doxepin; Drug and Narcotic Control; Dr | 1980 |
[Studies on the barbital-type physical dependence liability of mequitazine in mice and rats (author's transl)].
Topics: Animals; Barbital; Body Weight; Central Nervous System Depressants; Chlorpromazine; Diazepam; Histam | 1981 |
Benzodiazepine prescription to middle-aged women: it is done indiscriminately by family physicians?
Topics: Age Factors; Anti-Anxiety Agents; Canada; Diazepam; Female; Humans; Life Change Events; Marriage; Mi | 1982 |
Drug and alcohol problems in Kenya today: a review of research.
Topics: Adult; Alcoholism; Catha; Central Nervous System Stimulants; Diazepam; Female; Humans; Kenya; Male; | 1982 |
Physical dependence on diazepam and lorazepam in the dog.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Dogs; Female; Gait; Humans; Lorazepam; Pyrazole | 1983 |
Toluene inhalation and anxiolytic activity: possible synergism with diazepam.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Conflict, Psychological; Diazepam; Drug Synergism; H | 1983 |
Use of benzodiazepines in primary-care geriatric patients.
Topics: Aged; Ambulatory Care; Anti-Anxiety Agents; Anxiety; Attitude to Health; Diazepam; Female; Geriatric | 1984 |
Benzodiazepines: drug discrimination and physiological dependence.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Bromazepam; Diazepam; Discrimination Lear | 1984 |
Progress report on the stimulant-depressant abuse liability evaluation project.
Topics: Animals; Anti-Anxiety Agents; Arousal; Bromazepam; Diazepam; Discrimination Learning; Drug Evaluatio | 1984 |
Abuse liability and behavioral toxicity assessment: progress report from the behavioral biology laboratories of the Johns Hopkins University School of Medicine.
Topics: Animals; Anti-Anxiety Agents; Arousal; Behavior, Animal; Caffeine; Diazepam; Dose-Response Relations | 1984 |
[The need for psychopharmacologic therapy of drug addicts with acute hepatitis].
Topics: Acute Disease; Diazepam; Drug Therapy, Combination; Hepatitis; Heroin Dependence; Humans; Methadone; | 1984 |
The influence of haloperidol and aminooxyacetic acid on etonitazene, alcohol, diazepam and barbital consumption.
Topics: Acetates; Alcohol Drinking; Aminooxyacetic Acid; Animals; Barbital; Barbiturates; Benzimidazoles; Br | 1984 |
[Drug-induced pellagra].
Topics: Diazepam; Female; Humans; Middle Aged; Niacinamide; Pellagra; Phenacetin; Phenobarbital; Salicylamid | 1982 |
Incidence and toxicological aspects of drugs detected in 484 fatally injured drivers and pedestrians in Ontario.
Topics: Accidents, Traffic; Adolescent; Adult; Aged; Diazepam; Dronabinol; Ethanol; Female; Humans; Male; Mi | 1982 |
Dependence studies on zopiclone.
Topics: Animals; Azabicyclo Compounds; Barbiturates; Behavior, Animal; Diazepam; Humans; Hypnotics and Sedat | 1983 |
The effects of two nonpharmacological variables on drug preference in humans.
Topics: Adult; Amphetamine; Anxiety; Diazepam; Dose-Response Relationship, Drug; Emotions; Humans; Psycholog | 1983 |
Prevalence and implications of multi-drug abuse in a population of methadone-maintained women.
Topics: Amphetamine; Diazepam; Female; Heroin; Humans; Methadone; Narcotics; Opioid-Related Disorders; Pregn | 1983 |
Precipitated diazepam withdrawal in baboons: effects of dose and duration of diazepam exposure.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Flumazenil; | 1984 |
Diazepam tapering in detoxification for high-dose benzodiazepine abuse.
Topics: Adult; Benzodiazepines; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Fe | 1984 |
Bioassay of subjective effects associated with benzodiazepine withdrawal in animals: a novel direction in dependence research.
Topics: Animals; Benzodiazepinones; Biological Assay; Clonidine; Conditioning, Operant; Diazepam; Discrimina | 1984 |
Drug preference in humans: lorazepam.
Topics: Adult; Affect; Arousal; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Lorazepam; Male; | 1984 |
Methadone plasma levels and persistent drug abuse in high dose maintenance patients.
Topics: Alcohol Drinking; Diazepam; Dose-Response Relationship, Drug; Heroin Dependence; Humans; Methadone; | 1984 |
An evaluation of neonatal abstinence treatment modalities.
Topics: Central Nervous System Depressants; Diazepam; Drug Therapy, Combination; Humans; Infant, Newborn; In | 1984 |
Elimination kinetics and symptomatology of diazepam withdrawal in abusers.
Topics: Diazepam; Half-Life; Humans; Kinetics; Nordazepam; Substance Withdrawal Syndrome; Substance-Related | 1984 |
Benzodiazepine dependence of several years duration: clinical profile and therapeutic benefits.
Topics: Benzodiazepines; Diazepam; Female; Humans; Male; Psychotic Disorders; Substance Withdrawal Syndrome; | 1984 |
Diazepam and methadone interactions in methadone maintenance.
Topics: Administration, Oral; Adult; Blood Pressure; Diazepam; Double-Blind Method; Drug Synergism; Drug The | 1984 |
Parenteral abuse of diazepam: a case report.
Topics: Adult; Diazepam; Dystonia; Factitious Disorders; Humans; Injections, Intravenous; Male; Substance-Re | 1984 |
Cocaine abuse and its treatment.
Topics: Antidepressive Agents; Behavior Therapy; Cocaine; Cognition; Conditioning, Psychological; Diazepam; | 1984 |
[Pharmacological studies on drug dependence. (III): Intravenous self-administration of some CNS-affecting drugs and a new sleep-inducer, 1H-1, 2, 4-triazolyl benzophenone derivative (450191-S), in rats].
Topics: Animals; Central Nervous System Agents; Cocaine; Diazepam; Humans; Hypnotics and Sedatives; Injectio | 1984 |
Nurse self-injects valium: license revoked. Case in point: Stevens v. Blake (456 So. 2d 795 - AL).
Topics: Alabama; Diazepam; Humans; Licensure, Nursing; Male; Nursing Staff, Hospital; Substance-Related Diso | 1984 |
Students and drug abuse, 1974 and 1980.
Topics: Adolescent; Alcoholism; Aspirin; Child; Diazepam; Humans; Marijuana Abuse; Methaqualone; Students; S | 1983 |
Abuse potential of halazepam and of diazepam in patients recently treated for acute alcohol withdrawal.
Topics: Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Double-Blind Method; Ethan | 1983 |
Valium & values.
Topics: Diazepam; Drug Utilization; Humans; Substance-Related Disorders; United States | 1983 |
(--)-alpha-Acetylmethadol effects on alcohol and diazepam use, sexual function and cardiac function.
Topics: Adult; Alcohol Drinking; Blood Pressure; Diazepam; Electrocardiography; Heart; Heart Rate; Heroin De | 1983 |
Dependence potential of zopiclone studied in monkeys.
Topics: Administration, Oral; Animals; Azabicyclo Compounds; Barbital; Behavior, Animal; Diazepam; Female; H | 1983 |
Comparison of diazepam and oxazepam: preference, liking and extent of abuse.
Topics: Adult; Diazepam; Humans; Male; Middle Aged; Oxazepam; Reinforcement, Psychology; Substance-Related D | 1984 |
Impaired brain functions due to diazepam and meprobamate abuse in a 53-year-old-male.
Topics: Cognition Disorders; Diazepam; Humans; Male; Memory Disorders; Meprobamate; Middle Aged; MMPI; Motor | 1984 |
Psychophysical profiles differentiate drugs of abuse.
Topics: Amobarbital; Animals; Auditory Threshold; Barbiturates; Behavior, Animal; Chlordiazepoxide; Diazepam | 1981 |
Long-term use of diazepam.
Topics: Adult; Aged; Diazepam; Female; Humans; Kinetics; Male; Middle Aged; Muscle Cramp; Nordazepam; Pain; | 1981 |
Use of the specific benzodiazepine antagonist, Ro 15-1788, in studies of physiological dependence on benzodiazepines.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Cats; Diazepam; Female; Flumazenil; Humans; Lorazepam; | 1982 |
Progress report of the NIDA Addiction Research Center.
Topics: Analgesics; Buprenorphine; Chlordiazepoxide; Clonidine; Diazepam; Humans; Morphine; National Institu | 1982 |
The effect of a benzodiazepine antagonist, RO15-1788, in diazepam dependent rats.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Diazepam; Dose-Response Relationship, Drug; Female; Flu | 1982 |
Sex differences in substance abuse: 1976-1979.
Topics: Alcohol Drinking; Diazepam; Female; Heroin Dependence; Humans; Illicit Drugs; Male; Morphine Depende | 1983 |
Diazepam dose preference in humans.
Topics: Adult; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Fem | 1983 |
Coping with the negative therapeutic response in psychosocial problems in family medicine.
Topics: Adult; Dependency, Psychological; Depressive Disorder; Diazepam; Family Practice; Family Therapy; Fe | 1983 |
Diazepam and pentobarbital dependence in the rat.
Topics: Animals; Diazepam; Female; Humans; Pentobarbital; Rats; Rats, Inbred Strains; Substance Withdrawal S | 1982 |
Systems of reinforcement and drug dependence.
Topics: Amphetamines; Animals; Cats; Chlordiazepoxide; Cocaine; Diazepam; Drug Tolerance; Escape Reaction; E | 1982 |
Dependence potential of zopiclone studied in monkeys.
Topics: Administration, Oral; Animals; Azabicyclo Compounds; Barbital; Diazepam; Female; Humans; Hypnotics a | 1982 |
Unintentional haloperidol abuse.
Topics: Adult; Diazepam; Female; Haloperidol; Humans; Substance-Related Disorders | 1982 |
Drug preferences in humans.
Topics: Adult; Arousal; Dextroamphetamine; Diazepam; Emotions; Fenfluramine; Humans; Reinforcement, Psycholo | 1982 |
Treating substance-use disorders among physicians.
Topics: Adult; Alcoholics Anonymous; Alcoholism; Barbiturates; Diazepam; Female; Humans; Male; Middle Aged; | 1982 |
Amnesic effects of diazepam: "drug dependence" explained by state-dependent learning.
Topics: Adult; Amnesia; Diazepam; Female; Humans; Male; Memory; Substance-Related Disorders; Verbal Learning | 1982 |
Indicated preference for drugs of abuse.
Topics: Adolescent; Adult; Amphetamines; Cannabis; Cocaine; Codeine; Diazepam; Ethanol; Female; Heroin; Huma | 1982 |
Health care in jails: a unique challenge in medical practice.
Topics: Adult; Alcoholism; Cannabis; Diazepam; Ethics, Medical; Female; Health Services; Heroin; Humans; Mal | 1982 |
[Neuropharmacological studies on drug dependence (II). Changes in spontaneous motor activity, EEG and brain monoamines during the period of dependence development and of abrupt withdrawal in rats, with special reference to circadian rhythm (author's trans
Topics: Animals; Biogenic Amines; Brain; Circadian Rhythm; Cocaine; Diazepam; Electroencephalography; Humans | 1980 |
Delirium and stereotypy from anticholinergic antiparkinson drugs.
Topics: Adult; Aged; Benztropine; Delirium; Diazepam; Drug Therapy, Combination; Dyskinesia, Drug-Induced; E | 1982 |
Case report of unusual diazepam abstinence syndrome.
Topics: Diazepam; Female; Humans; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders | 1981 |
A neuroendocrine approach to benzodiazepine tolerance and dependence.
Topics: Adult; Benzodiazepines; Diazepam; Drug Tolerance; Growth Hormone; Humans; Male; Substance-Related Di | 1981 |
A clinical appraisal of diazepam.
Topics: Administration, Oral; Aged; Alcoholism; Anxiety; Child; Diazepam; Drug Administration Schedule; Huma | 1981 |
The use of valium as a form of social control.
Topics: Anxiety; Attitude; Diazepam; Humans; Social Problems; Substance-Related Disorders | 1981 |
Diazepam dependency and withdrawal.
Topics: Diazepam; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1981 |
Diazepam use among methadone maintenance patients: patterns and dosages.
Topics: Adult; Barbiturates; Benzodiazepines; Diazepam; Drug Synergism; Heroin Dependence; Humans; Male; Mar | 1981 |
The use of diazepam and of cocaine in combination with other drugs by Los Angeles County probationers.
Topics: Adult; Cocaine; Diazepam; Humans; Illicit Drugs; Male; Prisoners; Substance-Related Disorders | 1981 |
Long-term treatment with diazepam. Investigation of consumption habits and the interaction between psychotherapy and psychopharmacotherapy: a prospective study.
Topics: Adult; Diazepam; Double-Blind Method; Female; Humans; Intelligence Tests; Male; Neurotic Disorders; | 1981 |
A non-invasive method of qualitative and quantitative measurement of drugs.
Topics: Alcoholic Intoxication; Cocaine; Diazepam; Electronystagmography; Ethanol; Humans; Illicit Drugs; Ke | 1981 |
[The acute psychiatric emergency].
Topics: Acute Disease; Aged; Alcoholism; Amitriptyline; Brain Ischemia; Cognition Disorders; Consciousness D | 1981 |
The Drug Abuse Warning Network (DAWN) Program. Toxicologic verification of 1,008 emergency room 'mentions'.
Topics: Alcohol Drinking; Diazepam; Drug and Narcotic Control; Emergency Service, Hospital; Heroin; Humans; | 1980 |
Treatment of haloperidol abuse with diphenhydramine.
Topics: Adolescent; Adult; Alcohol Drinking; Diazepam; Diphenhydramine; Female; Haloperidol; Humans; Male; S | 1980 |
Withdrawal symptoms in the neonate from presumptive intrauterine exposure to diazepam: report of case.
Topics: Adolescent; Diazepam; Female; Fetal Growth Retardation; Fetus; Humans; Infant, Newborn; Male; Pregna | 1980 |
Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines.
Topics: Benzodiazepines; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Flurazepam; Humans; Lorazepam; | 1980 |
Premedication with habituating drugs.
Topics: Diazepam; Humans; Premedication; Substance-Related Disorders | 1980 |
Pharmacodymamics and pharmacokinetics of diazepam in an abuser.
Topics: Adult; Diazepam; Double-Blind Method; Humans; Kinetics; Male; Placebos; Substance-Related Disorders | 1980 |
Drug preference in humans: double-blind choice comparison of pentobarbital, diazepam and placebo.
Topics: Adult; Behavior; Diazepam; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Hu | 1980 |
Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat.
Topics: Animals; Anti-Anxiety Agents; Antidotes; Biological Availability; Delayed-Action Preparations; Diaze | 1995 |
Precipitated withdrawal in squirrel monkeys after repeated daily oral administration of alprazolam, diazepam, flunitrazepam or oxazepam.
Topics: Administration, Oral; Alprazolam; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, D | 1995 |
Promotes diazepam as safe, effective.
Topics: Diazepam; Humans; Substance-Related Disorders | 1995 |
Neuropharmacology of a new potential anxiolytic compound, F 2692, 1-(3'-trifluoromethyl phenyl) 1, 4-dihydro 3-amino 4-oxo 6-methyl pyridazine. 2. Evaluation of its tolerance and dependence producing potential and of its effects on benzodiazepine withdraw
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Drug Tol | 1993 |
Repeated treatment with alpidem, a new anxiolytic, does not induce tolerance or physical dependence.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bicuculline; Carbolines; Convulsants; Diazepam; Drug | 1993 |
Effects of serotonergic anxiolytics on physical dependence on diazepam in mice.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Carbolines; Diazepam; Drug Synergism; Epilepsy, Tonic-Cloni | 1993 |
Alprazolam modifies animal behaviour on elevated plus-maze.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Diazepam; Learning; Mice; Mice, | 1993 |
Imidazenil, a partial positive allosteric modulator of GABAA receptors, exhibits low tolerance and dependence liabilities in the rat.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Brain; Diazepam | 1994 |
Clinical observations on substance abuse related health problems at the Port Moresby General Hospital, National Capital District, Papua New Guinea.
Topics: Adolescent; Adult; Alcoholism; Cross-Sectional Studies; Diazepam; Female; Humans; Incidence; Male; M | 1994 |
Inhibition of morphine tolerance and dependence by diazepam and its relation to the CNS Met-enkephalin levels.
Topics: Animals; Central Nervous System; Diazepam; Drug Implants; Drug Tolerance; Enkephalin, Methionine; Ho | 1994 |
Long-term treatment with abecarnil does not induce diazepam-like dependence in mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Carbolines; Diazepam; Electromyography; Male; Mice; Receptors | 1993 |
Are rapid inpatient benzodiazepine detoxifications unsafe?
Topics: Adult; Anti-Anxiety Agents; Diazepam; Epilepsy, Tonic-Clonic; Female; Humans; Inpatients; Substance | 1993 |
Potentiation of physical dependence on diazepam by ondansetron in rats.
Topics: Animals; Body Weight; Diazepam; Drug Synergism; Male; Ondansetron; Rats; Rats, Inbred F344; Substanc | 1994 |
Lack of cognitive recovery following withdrawal from long-term benzodiazepine use.
Topics: Adult; Benzodiazepines; Cognition Disorders; Diazepam; Female; Humans; Male; Memory Disorders; Middl | 1994 |
Effects of Ca2+ channel blockers on physical dependence on diazepam in mice.
Topics: Animals; Brain; Calcium Channel Blockers; Carbolines; Diazepam; Diltiazem; Drug Interactions; Flunar | 1993 |
Precipitated abstinence in the diazepam-dependent rat.
Topics: Animals; Behavior, Animal; Brain; Diazepam; Drug Implants; Epilepsy, Tonic-Clonic; Female; Flumazeni | 1993 |
Diazepam dependence prevented by glutamate antagonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Diazepam; Drug Tolerance; Electroencephalography; Ele | 1993 |
[Benzodiazepine withdrawal syndrome in newborn infants. Clinical cases].
Topics: Benzodiazepines; Diazepam; Female; Gestational Age; Humans; Infant, Newborn; Male; Pregnancy; Pregna | 1993 |
Pharmacokinetics of nordiazepam in physical dependence and precipitated abstinence in dogs.
Topics: Administration, Oral; Animals; Blood Proteins; Diazepam; Dogs; Female; Flumazenil; Hydrolysis; Injec | 1993 |
Effects of nifedipine on physical dependence on barbital or diazepam in rats.
Topics: Analysis of Variance; Animals; Barbital; Body Weight; Calcium Channel Blockers; Calcium Channels; Di | 1995 |
Changes in GABAA receptor function and cross-tolerance to ethanol in diazepam-dependent rats.
Topics: Alcoholic Intoxication; Animals; Cerebral Cortex; Chloride Channels; Culture Techniques; Diazepam; D | 1996 |
Diazepam physical dependence and withdrawal in rats is associated with alteration in GABAA receptor function.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Chloride Channels; Chlorides; Diazepam; Flumazenil; Fluni | 1996 |
[Tuberculous meningitis].
Topics: Depressive Disorder; Diagnosis, Differential; Diazepam; Female; Humans; Middle Aged; Neurocognitive | 1996 |
Long-term studies on anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. I. Comparison of diazepam, clonazepam, clobazam and abecarnil.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Carbolines; Cloba | 1996 |
A nonbenzodiazepine partial agonist, S-(+)-DN-2327, has minimal physical dependence-producing liability, but shows cross-dependence on barbital in rats.
Topics: Animals; Anti-Anxiety Agents; Area Under Curve; Barbital; Behavior, Animal; Binding, Competitive; Bo | 1996 |
[Complications after benzodiazepine dependence].
Topics: Anti-Anxiety Agents; Combined Modality Therapy; Diazepam; Female; Humans; Middle Aged; Neuropsycholo | 1996 |
Benzodiazepine misuse by drug addicts.
Topics: Alcoholism; Benzodiazepines; Chromatography, High Pressure Liquid; Diazepam; Humans; Narcotics; Nitr | 1997 |
Noise stress and the development of benzodiazepine dependence in the rat.
Topics: Animals; Anti-Anxiety Agents; Arousal; Diazepam; Drug Tolerance; Exploratory Behavior; Injections, I | 1994 |
Effects of acute daily administration of diazepam on spatial learning and working memory.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedu | 1997 |
Dorsal raphe and substantia nigra response to flumazenil in diazepam-dependent rats.
Topics: Animals; Diazepam; Electroencephalography; Electrophysiology; Female; Flumazenil; GABA Modulators; M | 1997 |
An epidemiological survey on use and abuse of antianxiety drugs among Beijing residents.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Behavior, Addictive; Benzodiazepines; Child; China; Di | 1996 |
Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats.
Topics: Animals; Bromocriptine; Buprenorphine; Cocaine; Desipramine; Diazepam; Dizocilpine Maleate; Hemodyna | 1997 |
Comparison of abstinence syndromes precipitated by flumazenil and PK 11195 in female diazepam-dependent rats.
Topics: Animals; Anti-Anxiety Agents; Central Nervous System; Diazepam; Dose-Response Relationship, Drug; Dr | 1997 |
Benzodiazepine dependence: from neural circuits to gene expression.
Topics: Animals; Anti-Anxiety Agents; Antimetabolites; Autoradiography; Brain Chemistry; Deoxyglucose; Diaze | 1998 |
Sarmazenil-precipitated withdrawal: a reliable method for assessing dependence liability of benzodiazepine receptor ligands.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Convulsants; Diazepam; Drug Toleran | 1998 |
[Effect of calcium channel blocker nifedipine on anxiety and seizure manifestations of abstinence syndrome in rats after withdrawal of long-term diazepam administration].
Topics: Adaptation, Physiological; Animals; Anti-Anxiety Agents; Anxiety; Calcium Channel Blockers; Calcium | 1998 |
Contingent tolerance, compensatory responses, and physical dependence in diazepam-treated amygdala-kindled rats.
Topics: Amygdala; Animals; Anti-Anxiety Agents; Brain Mapping; Diazepam; Drug Tolerance; Electroencephalogra | 1998 |
Phencyclidine- and diazepam-like discriminative stimulus effects of inhalants in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Diazepam; Discrimination, Psychological; Dose-Respon | 1999 |
Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side-effects in mice.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Bicuculline; Biphenyl Compounds; Diazepam; Hexobarbi | 1999 |
The alcohol withdrawal syndrome.
Topics: Alcoholism; Chlordiazepoxide; Diazepam; Drug Tolerance; Ethanol; Hospitalization; Humans; Substance | 1979 |
Polydrug abuse in heroin addicts: a behavioral economic analysis.
Topics: Adult; Choice Behavior; Cocaine; Diazepam; Ethanol; Female; Heroin; Humans; Income; Male; Marijuana | 1998 |
Physical dependence after benzodiazepine treatments in rats: Comparison of short and long treatments with diazepam and lorazepam.
Topics: Animals; Anti-Anxiety Agents; Arousal; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Admin | 1999 |
Prescribing and dispensing for drug misusers in primary care: current practice in Scotland.
Topics: Analgesics, Opioid; Anti-Anxiety Agents; Codeine; Community Pharmacy Services; Diazepam; Drug Prescr | 1999 |
Substantia nigra: the involvement of central and peripheral benzodiazepine receptors in physical dependence on diazepam as evidenced by behavioral and EEG effects.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Behavior, Animal; Central Nervous System; Diaze | 1999 |
Precipitated withdrawal in the substantia nigra in diazepam-dependent female rats.
Topics: Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Electroencephalography; Female; Flumazenil; GAB | 1999 |
Leo Sternbach. Valium. The father of mother's little helpers.
Topics: Anti-Anxiety Agents; Diazepam; Drug Industry; Drug Utilization; Humans; Substance-Related Disorders; | 1999 |
Acute opioid but not benzodiazepine dependence in rats responding for intracranial self-stimulation.
Topics: Animals; Benzodiazepines; Brain; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Morph | 2000 |
The treatment of sedative-hypnotic dependence: evaluating clinical predictors of outcome.
Topics: Adult; Alcoholism; Benzodiazepines; Clonazepam; Combined Modality Therapy; Comorbidity; Diazepam; Dr | 2000 |
Diazepam in the ventral striatum dissociates dopamine-dependent and dopamine-independent place conditioning.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amphetamin | 2000 |
The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Body Weight; Brain; Diazepam; Female; Flumazeni | 2000 |
Diazepam in the treatment of GHB dependence.
Topics: Anti-Anxiety Agents; Diazepam; Humans; Sodium Oxybate; Substance Withdrawal Syndrome; Substance-Rela | 2001 |
Anxiogenic-like effects limit rewarding effects of cocaine in balb/cbyj mice.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Brain; Caudate Nucleus; Cocaine; Conditioning, Operant; Diaze | 2001 |
A behavioral economic analysis of polydrug abuse in alcoholics: asymmetrical substitution of alcohol and cocaine.
Topics: Adult; Alcoholic Beverages; Alcoholism; Analysis of Variance; Cocaine; Cocaine-Related Disorders; Di | 2001 |
Glutamic acid decarboxylase and glutamate receptor changes during tolerance and dependence to benzodiazepines.
Topics: Animals; Brain; Diazepam; Drug Tolerance; Frontal Lobe; GABA Modulators; Gene Expression Profiling; | 2001 |
Sensitivity to the effects of sedative-hypnotics on motor performance: influence of task difficulty and chronic phenobarbital administration.
Topics: Amobarbital; Animals; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Dru | 2001 |
[A case of primary zopiclone dependence].
Topics: Anti-Anxiety Agents; Attention; Azabicyclo Compounds; Depression; Diazepam; Female; Humans; Hypnotic | 2001 |
Increase in expression of the GABA(A) receptor alpha(4) subunit gene induced by withdrawal of, but not by long-term treatment with, benzodiazepine full or partial agonists.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cell Membrane; Cells, Cultured; Cerebellum; Chloride | 2001 |
Drug related deaths in the Strathclyde region of Scotland, 1995-1998.
Topics: Adolescent; Adult; Cause of Death; Diazepam; Female; Humans; Incidence; Male; Methadone; Middle Aged | 2001 |
WHO Expert Committee on Drug Dependence. Thirty-second report.
Topics: Amphetamines; Buprenorphine; Carisoprodol; Diazepam; Dibenzocycloheptenes; Diethylpropion; Dronabino | 2001 |
The other learning process in substance abuse: comment on Alessi, Roll, Reilly, and Johanson (2002).
Topics: Conditioning, Classical; Conditioning, Operant; Diazepam; Humans; Learning; Substance-Related Disord | 2002 |
Drugs as reinforcers--collaborative opportunities in epidemiology and behavioral pharmacology: comment on Alessi, Roll, Reilly, and Johanson (2002).
Topics: Anti-Anxiety Agents; Diazepam; Epidemiologic Methods; Humans; Longitudinal Studies; Reinforcement, P | 2002 |
Conditioning history and the reinforcing effects of drugs: comment on Alessi, Roll, Reilly, and Johanson (2002).
Topics: Anti-Anxiety Agents; Conditioning, Operant; Diazepam; Disease Progression; Humans; Psychomotor Perfo | 2002 |
Modulation of the subjective and physiological effects of drugs by contexts and expectations--the search for mechanisms: comment on Alessi, Roll, Reilly, and Johanson (2002).
Topics: Anti-Anxiety Agents; Conditioning, Operant; Diazepam; Humans; Reinforcement, Psychology; Research De | 2002 |
Induction of aneuploidy in male mouse germ cells detected by the sperm-FISH assay: a review of the present data base.
Topics: Acrylamide; Aneuploidy; Animals; Benzimidazoles; Carbamates; Colchicine; Diazepam; Griseofulvin; Hum | 2002 |
Diazepam abuse: incidence, rapid screening, and confirming methods.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Chromatography, Gas; Diazepam; Ethanol; Hum | 1976 |
Recent advances in alcohol withdrawal states.
Topics: Adrenergic beta-Antagonists; Adult; Alcoholism; Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Hum | 1977 |
The benzodiazepines.
Topics: Anti-Anxiety Agents; Chlordiazepoxide; Diazepam; Humans; Substance Withdrawal Syndrome; Substance-Re | 1978 |
High-dose benzodiazepines in the treatment of severe neurotic anxiety.
Topics: Adult; Aged; Anti-Anxiety Agents; Anxiety Disorders; Diazepam; Female; Flurazepam; Humans; Male; Oxa | 1978 |
Abuse of benzodiazepines.
Topics: Alcoholism; Anti-Anxiety Agents; Chlormethiazole; Diazepam; Drug Synergism; Humans; Lorazepam; Male; | 1978 |
Benzodiazepine abuse in alcoholics.
Topics: Alcoholism; Diazepam; Humans; Substance-Related Disorders | 1978 |
Gynaecomastia and diazepam abuse.
Topics: Diazepam; Gynecomastia; Humans; Male; Middle Aged; Prolactin; Substance-Related Disorders | 1979 |
Drug self-administration in humans.
Topics: Adult; Arousal; Dextroamphetamine; Diazepam; Diethylpropion; Emotions; Female; Humans; Male; Placebo | 1978 |
[Experimental study on development of physical dependence on alcohol and cross physical dependence liability of diazepam and barbital to alcohol in rhesus monkeys (author's transl)].
Topics: Alcoholism; Animals; Barbital; Barbiturates; Body Weight; Diazepam; Female; Haplorhini; Humans; Maca | 1978 |
Reinforcement of drug abstinence: a behavioral approach to drug abuse treatment.
Topics: Adult; Alcoholism; Behavior Therapy; Diazepam; Heroin Dependence; Humans; Methadone; Opioid-Related | 1979 |
The use of psychoactive drugs in the long-term treatment of chronic alcoholics.
Topics: Alcoholism; Anti-Anxiety Agents; Antipsychotic Agents; Anxiety; Chlordiazepoxide; Chlorpromazine; Ch | 1975 |
The treatment of alcoholism: what do we do about long-term sedatives?
Topics: Alcoholics Anonymous; Alcoholism; Anti-Anxiety Agents; Attitude of Health Personnel; Chlordiazepoxid | 1975 |
EEG and psychopharmacology.
Topics: Animals; Benzodiazepines; Biological Availability; Bromazepam; Cannabinoids; Cycloserine; Diazepam; | 1978 |
Specific conductivity of urine and sensitivity of enzyme immunoassay methods of analysis for drugs of abuse.
Topics: Amphetamine; Dextropropoxyphene; Diazepam; Electric Conductivity; Female; Humans; Immunoenzyme Techn | 1977 |
Diazepam-induced coma with bullae and eccrine sweat gland necrosis.
Topics: Adult; Coma; Diazepam; Humans; Male; Necrosis; Skin Diseases, Vesiculobullous; Substance-Related Dis | 1977 |
Single case study. Diazepam (Valium) detoxification.
Topics: Adult; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Metabolic Clearance Rate; Nordaze | 1979 |
Drug abuse and dependency in patients with chronic pain.
Topics: Age Factors; Chronic Disease; Codeine; Dextropropoxyphene; Diazepam; Female; Humans; Intelligence; M | 1979 |
Outpatient treatment and outcome of prescription drug abuse.
Topics: Adult; Ambulatory Care; Amphetamines; Anxiety; Barbiturates; Counseling; Depression; Diazepam; Drug | 1979 |
Countering diazepam abuse.
Topics: Diazepam; Emergency Service, Hospital; Humans; Substance-Related Disorders | 1979 |
Thrombocytosis and increased circulating platelet aggregates in newborn infants of polydrug users.
Topics: Amphetamine; Cocaine; Diazepam; Female; Heroin Dependence; Humans; Infant; Infant, Newborn; Infant, | 1979 |
A guide to the use of hypnotic drugs.
Topics: Benzodiazepines; Chlordiazepoxide; Clorazepate Dipotassium; Diazepam; Drug Interactions; Flurazepam; | 1979 |
Working through anxiety to combat diazepam abuse.
Topics: Diazepam; Humans; New York; Pharmacy Service, Hospital; Substance-Related Disorders | 1979 |
Diazepam-ethanol interaction in humans: addition or potentiation?
Topics: Adolescent; Adult; Alcohol Drinking; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Eth | 1979 |
University infirmary admissions for drug abuse, 1968--1970 and 1973--1975.
Topics: Adult; Aspirin; Cannabis; Diazepam; Female; Hallucinogens; Humans; Male; Patient Admission; Student | 1979 |
[Gynecomastia during benzodiazepine abuse].
Topics: Diazepam; gamma-Aminobutyric Acid; Gynecomastia; Humans; Male; Middle Aged; Pituitary Gland, Anterio | 1979 |
Diazepam addiction in Kenya.
Topics: Adult; Diazepam; Female; Humans; Kenya; Male; Middle Aged; Substance-Related Disorders | 1979 |
Frequency of use of diazepam in individuals on probation and in methadone maintenance programs.
Topics: Diazepam; Heroin Dependence; Humans; Illicit Drugs; Methadone; Prisoners; Substance-Related Disorder | 1979 |
Valium: a discussion of current issues.
Topics: Age Factors; Ambulatory Care; Anxiety; Automobile Driving; Diazepam; Drug Interactions; Drug Labelin | 1977 |
[Drug withdrawl symptoms in newborn infants of addicted mothers].
Topics: Adult; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Maternal-Fetal Exchange | 1977 |
Some observations concerning blood morphine concentrations in narcotic addicts.
Topics: Diazepam; Ethanol; Heroin; Homicide; Humans; Morphine; Poisoning; Quinine; Substance-Related Disorde | 1977 |
Diazepam addiction: a case report.
Topics: Adult; Akathisia, Drug-Induced; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Substanc | 1978 |
Problems pertaining to the care of newborn infants of drug-addicted women.
Topics: Apnea; Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Methadone; Narcotics; P | 1978 |
Thin-layer detection of diazepam and/or chilordiazepoxide alone or in combination with major drugs of abuse in drug abuse urine screening programs.
Topics: Chlordiazepoxide; Chromatography, Thin Layer; Clorazepate Dipotassium; Diazepam; Humans; Indicators | 1978 |
[Diazepam and alcohol].
Topics: Diazepam; Drug Synergism; Ethanol; Humans; Substance-Related Disorders | 1978 |
[Scientifically proven hazards for the child].
Topics: Abortion, Habitual; Adult; Chromosome Aberrations; Diazepam; Female; Fetal Diseases; Fetus; Humans; | 1977 |
Diazepam withdrawal psychosis: a case report.
Topics: Alcoholism; Diazepam; Dose-Response Relationship, Drug; Humans; Male; Middle Aged; Psychotic Disorde | 1977 |
Phencyclidine-a different hallucinogen.
Topics: Diazepam; Hallucinations; Humans; Phencyclidine; Phenytoin; Substance-Related Disorders | 1977 |
Neonatal seizures associated with narcotic withdrawal.
Topics: Diazepam; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Opium; Phenobarbital; Pregnanc | 1977 |
Clinical pharmacology of phencyclidine toxicity.
Topics: Cognition; Diazepam; Dose-Response Relationship, Drug; Humans; Personality; Phencyclidine; Psychoses | 1977 |
Human sedative self-administration: effects of interingestion interval and dose.
Topics: Adult; Behavior; Diazepam; Drug Administration Schedule; Ethanol; Humans; Hypnotics and Sedatives; M | 1976 |
Herbal cigarettes for kicks.
Topics: Adolescent; Adult; Datura stramonium; Diazepam; Female; Humans; Male; Plants, Medicinal; Plants, Tox | 1976 |
Effects of response requirement upon human sedative self-administration and drug-seeking behavior.
Topics: Adult; Behavior; Diazepam; Drug Tolerance; Humans; Hypnotics and Sedatives; Male; Pentobarbital; Rew | 1976 |
Editorial: Obsolescent drugs.
Topics: Barbiturates; Dentists; Diazepam; Drug Prescriptions; Humans; Substance-Related Disorders; United Ki | 1975 |
Nitrous oxide analgesia--possible addiction.
Topics: Diazepam; Humans; Nitrous Oxide; Substance-Related Disorders | 1975 |
Management of hallucinogen abuse.
Topics: Adolescent; Adult; Amphetamines; Basidiomycota; Cannabis; Child; Condiments; Diazepam; Fruit; Halluc | 1976 |
Viral hepatitis with intracytoplasmic cholestasis and cholesterol crystals in a drug addict.
Topics: Acute Disease; Adolescent; Cholestasis; Cholesterol; Crystallization; Cytoplasm; Diazepam; Female; H | 1975 |
Methylphenidate (ritalin) abuse and methadone maintenance.
Topics: Adult; Amphetamine; Atropa belladonna; Barbiturates; Diazepam; Female; Heroin Dependence; Humans; Ma | 1975 |
[Withdrawal psychosis developing in association with incarceration in a penal institution].
Topics: Adult; Alcoholism; Diazepam; Humans; Male; Prisons; Psychotic Disorders; Substance Withdrawal Syndro | 1975 |
[New born infants of drug addicted mothers].
Topics: Adolescent; Adult; Birth Weight; Chlorpromazine; Diazepam; Female; Humans; Infant, Newborn; Infant, | 1975 |
[Diseases caused by drug therapy in newborn babies].
Topics: Apgar Score; Diazepam; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Female; H | 1975 |
[Radioimmunoassay of drugs capable of inducing dependency].
Topics: Barbiturates; Carbodiimides; Diazepam; Dronabinol; Hemagglutination Inhibition Tests; Humans; Lyserg | 1975 |
[Comparison of development of drug dependence in naive and drug dependence-experienced rats].
Topics: Administration, Oral; Animals; Body Weight; Chlordiazepoxide; Diazepam; Eating; Female; Humans; Male | 1975 |
[Dependence on and preference for morphine (II). Comparison among morphine, phenobarbital and diazepam].
Topics: Animals; Body Weight; Choice Behavior; Decision Making; Diazepam; Female; Humans; Male; Methods; Mor | 1975 |
Narcotic addiction in the newborn: differences in behavior generated by methadone and heroin.
Topics: Adaptation, Physiological; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, New | 1975 |
Letter: Withdrawal of diazepam.
Topics: Diazepam; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1975 |
Misuse and abuse of diazepam: an increasingly common medical problem.
Topics: Adult; Diazepam; Drug Prescriptions; Heroin Dependence; Humans; Legislation, Drug; Male; Methadone; | 1975 |
Physiologic and biochemical abnormalities in self-induced drug overdosage.
Topics: Adolescent; Adult; Aged; Aspirin; Barbiturates; Body Temperature; Carbamates; Creatine Kinase; Diaze | 1975 |
Letter: Diazepam withdrawal symptoms.
Topics: Diazepam; Female; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1975 |
Experimental human drug self-administration: methodology and application to the study of sedative abuse.
Topics: Adult; Behavior; Diazepam; Environment; Humans; Male; Pentobarbital; Substance-Related Disorders; To | 1975 |
[New technic for rapid drug withdrawal for drug addicts: preliminary communication].
Topics: Adult; Amobarbital; Chlorpromazine; Diazepam; Humans; Male; Methods; Methotrimeprazine; Promethazine | 1975 |
Physical dependence on morphine, phenobarbital and diazepam in rats by drug-admixed food ingestion.
Topics: Animals; Body Weight; Diazepam; Diet; Feeding Behavior; Female; Humans; Levallorphan; Male; Morphine | 1975 |
Addiction to diazepam.
Topics: Administration, Oral; Adult; Age Factors; Anxiety; Diazepam; Drug Tolerance; Female; Humans; Male; M | 1976 |
How to get patients off barbiturates.
Topics: Barbiturates; Diazepam; Humans; Nitrazepam; Substance Withdrawal Syndrome; Substance-Related Disorde | 1976 |
Drug addiction in pregnancy and the neonate.
Topics: Alcoholic Intoxication; Birth Weight; Diazepam; Female; Heroin Dependence; Hospitalization; Humans; | 1976 |
Detoxification for triazolam physical dependence.
Topics: Adult; Alcoholism; Diazepam; Dose-Response Relationship, Drug; Female; Half-Life; Hospitalization; H | 1992 |
Physical dependence on diazepam: precipitation of abstinence syndromes by peripheral and central benzodiazepine receptor antagonists.
Topics: Animals; Diazepam; GABA-A Receptor Antagonists; Male; Rats; Rats, Inbred Strains; Receptors, GABA-A; | 1992 |
Self-help and benzodiazepine withdrawal.
Topics: Adult; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Female; Follow-Up Studies; H | 1992 |
Genetic differences in the development of physical dependence upon diazepam in Lewis and Fischer 344 inbred rat strains.
Topics: Animals; Body Weight; Diazepam; Eating; Growth; Male; Postural Balance; Psychomotor Performance; Rat | 1992 |
Tolerance, cross-tolerance and withdrawal in rats made dependent on diazepam.
Topics: Animals; Chlordiazepoxide; Diazepam; Discrimination Learning; Dose-Response Relationship, Drug; Drug | 1992 |
Oral self-administration of triazolam, diazepam and ethanol in the baboon: drug reinforcement and benzodiazepine physical dependence.
Topics: Animals; Conditioning, Operant; Diazepam; Drinking Behavior; Ethanol; Flumazenil; Food; Half-Life; M | 1992 |
Factors predicting long-term outcome after chronic benzodiazepine therapy.
Topics: Adult; Age Factors; Benzodiazepines; Diazepam; Employment; Female; Follow-Up Studies; Humans; Male; | 1992 |
Locomotor responses of FAST and SLOW mice to several alcohols and drugs of abuse.
Topics: Alcohols; Animals; Caffeine; Dextroamphetamine; Diazepam; Mice; Mice, Inbred Strains; Motor Activity | 1992 |
Behavioral effects of benzodiazepine ligands in non-dependent, diazepam-dependent and diazepam-withdrawn baboons.
Topics: Animals; Behavior, Animal; Benzodiazepines; Carbolines; Diazepam; Dose-Response Relationship, Drug; | 1991 |
Snorting benzodiazepines.
Topics: Administration, Intranasal; Adult; Alprazolam; Anti-Anxiety Agents; Arousal; Bipolar Disorder; Diaze | 1991 |
Chronic administration of and dependence on halazepam, diazepam, and nordiazepam in the dog.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Brain; Diaze | 1991 |
Treatment of benzodiazepine withdrawal symptoms with carbamazepine.
Topics: Adult; Anti-Anxiety Agents; Anxiety; Arousal; Carbamazepine; Crisis Intervention; Depression; Diazep | 1991 |
[Traffic chemistry--seen in the rear-view mirror].
Topics: Accidents, Traffic; Automobile Driving; Denmark; Diazepam; Drug-Related Side Effects and Adverse Rea | 1992 |
Effect of peripheral administration of cinnarizine and verapamil on the abstinence syndrome in diazepam-dependent rats.
Topics: Animals; Autonomic Nervous System; Behavior, Animal; Cinnarizine; Diazepam; Female; Male; Motor Acti | 1992 |
Distribution of diazepam, nordiazepam, and oxazepam between brain extraneuronal space, brain tissue, plasma, and cerebrospinal fluid in diazepam and nordiazepam dependent dogs.
Topics: Animals; Brain; Diazepam; Dogs; Extracellular Space; Female; Nordazepam; Oxazepam; Substance-Related | 1991 |
Treatment of panic disorder and benzodiazepine withdrawal with valproate.
Topics: Adult; Agoraphobia; Clonazepam; Diazepam; Dose-Response Relationship, Drug; Humans; Male; Panic Diso | 1991 |
A comparison of the physical dependence inducing properties of flunitrazepam and diazepam.
Topics: Animals; Biotransformation; Blood Proteins; Brain Chemistry; Diazepam; Dogs; Dose-Response Relations | 1991 |
[Incidence of drugs and euphoretic agents among motorists on the roads of Denmark. A possible relationship to traffic safety].
Topics: Accidents, Traffic; Adult; Aged; Alcohol Drinking; Automobile Driving; Denmark; Diazepam; Female; Hu | 1991 |
A theory of benzodiazepine dependence that can explain whether flumazenil will enhance or reverse the phenomena.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Flumazenil; Male; Rats; Substance Withdrawal Syndro | 1990 |
Investigations with the novel non-opioid analgesic flupirtine in regard to possible benzodiazepine-like abuse inducing potential.
Topics: Aminopyridines; Analgesics; Animals; Anti-Anxiety Agents; Binding, Competitive; Body Weight; Brain C | 1990 |
Physical dependence induced in DBA/2J mice by benzodiazepine receptor full agonists, but not by the partial agonist Ro 16-6028.
Topics: Administration, Oral; Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepinones; Diazepam; Drug Im | 1990 |
Carbamazepine for high-dose diazepam withdrawal in opiate users.
Topics: Adult; Carbamazepine; Diazepam; Female; Humans; Male; Methadone; Opioid-Related Disorders; Substance | 1991 |
Urinary retention as a possible complication of long-term diazepam abuse.
Topics: Diazepam; Humans; Male; Substance-Related Disorders; Urinary Retention | 1991 |
Differences in the medical and legal viewpoint illustrated by R v Hardie [1984].
Topics: Attitude to Health; Diazepam; England; Firesetting Behavior; History, 20th Century; Insanity Defense | 1991 |
Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam.
Topics: Adult; Diazepam; Drug Combinations; Female; Humans; Infant; Milk, Human; Nordazepam; Oxazepam; Subst | 1990 |
Five year outcome in patients withdrawn from long term treatment with diazepam.
Topics: Diazepam; Female; Follow-Up Studies; Humans; Long-Term Care; Male; Mental Disorders; Outcome and Pro | 1990 |
Substitution of psychoactive drugs in pentobarbital-dependent rats.
Topics: Animals; Antidepressive Agents; Arousal; Body Weight; Brain; Bromazepam; Bupropion; Diazepam; Dose-R | 1990 |
Cyclopyrrolones, unlike some benzodiazepines, do not induce physical dependence in mice.
Topics: Animals; Azabicyclo Compounds; Carbolines; Convulsants; Diazepam; Disease Models, Animal; Flunitraze | 1990 |
Subjective feelings of anxiety in young men after ethanol and diazepam infusions.
Topics: Adult; Affect; Alcohol Drinking; Alcoholic Beverages; Alcoholism; Anxiety; Diazepam; Dose-Response R | 1990 |
Diazepam abuse in pregnant women on methadone maintenance. Implications for the neonate.
Topics: Adult; Diazepam; Drug Therapy, Combination; Female; Humans; Infant, Newborn; Infant, Newborn, Diseas | 1990 |
The effect of ketotifen in rodent models of anxiety and on the behavioural consequences of withdrawing from treatment with drugs of abuse.
Topics: Animals; Anxiety; Behavior, Animal; Cocaine; Conditioning, Operant; Diazepam; Ethanol; Ketotifen; Ma | 1990 |
Ethanol and diazepam withdrawal convulsions are extensively codetermined in WSP and WSR mice.
Topics: Animals; Diazepam; Ethanol; Flumazenil; Mice; Mice, Inbred Strains; Seizures; Substance Withdrawal S | 1989 |
Prescribing of benzodiazepines by casualty officers.
Topics: Adolescent; Adult; Aged; Anti-Anxiety Agents; Child; Diazepam; Drug Utilization; Emergency Medicine; | 1989 |
Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Carbolines; Diazepam; Dogs; Female; Flumazenil; Nord | 1989 |
Panic attacks and major depression after discontinuation of long-term diazepam abuse.
Topics: Adult; Anxiety; Clomipramine; Depressive Disorder; Diazepam; Fear; Female; Humans; Panic; Substance | 1989 |
The effect of ethanol on 35S-TBPS binding to mouse brain membranes in the presence of chloride.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 1989 |
Effects of repeated RO 15-1788 administration in benzodiazepine-dependent baboons.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepinones; Convulsants; Diazepam; Drug Tolerance; Flumazenil; | 1985 |
Triazolam addiction.
Topics: Adult; Anti-Anxiety Agents; Diazepam; Humans; Male; Substance Withdrawal Syndrome; Substance-Related | 1985 |
The risk of pharmacological dependence with buspirone.
Topics: Anti-Anxiety Agents; Buspirone; Diazepam; Humans; Pyrimidines; Risk; Substance Withdrawal Syndrome; | 1985 |
[Problem of transient dementias of old age (clinico-diagnostic aspect)].
Topics: Aged; Amphetamine; Anxiety; Central Nervous System Stimulants; Dementia; Depressive Disorder; Diagno | 1985 |
Patterns of benzodiazepine abuse and dependence.
Topics: Adult; Anti-Anxiety Agents; Diazepam; Female; Humans; Male; Middle Aged; Referral and Consultation; | 1986 |
Benzodiazepine dependence in mice after ingestion of drug-containing food pellets.
Topics: Aggression; Animals; Anti-Anxiety Agents; Body Weight; Diazepam; Eating; Male; Mice; Substance Withd | 1986 |
Alprazolam dependence in mice.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Diazepam; Male; Mice; Models, Psychological; Substance Wit | 1987 |
Benzodiazepine dependent patients and their psychological treatment.
Topics: Adaptation, Psychological; Adult; Anti-Anxiety Agents; Behavior Therapy; Combined Modality Therapy; | 1988 |
[Abuse of licit drugs in heroin addicts].
Topics: Adolescent; Adult; Anti-Anxiety Agents; Diazepam; Female; Flunitrazepam; Heroin Dependence; Humans; | 1987 |
The natural history of tolerance to the benzodiazepines.
Topics: Adult; Affect; Anti-Anxiety Agents; Arousal; Attention; Diazepam; Dose-Response Relationship, Drug; | 1988 |
Managing cocaine crisis.
Topics: Arrhythmias, Cardiac; Cocaine; Diazepam; Humans; Hypertension; Labetalol; Seizures; Substance-Relate | 1989 |
Preference for alprazolam over diazepam.
Topics: Alprazolam; Attitude; Diazepam; Humans; Risk Factors; Substance-Related Disorders | 1989 |
A retrospective study of drugged driving in Norway.
Topics: Adolescent; Adult; Age Factors; Amphetamine; Automobile Driving; Diazepam; Dronabinol; Ethanol; Fema | 1987 |
Major patterns of polydrug abuse among heroin addicts.
Topics: Alcoholism; Amphetamines; Barbiturates; Cannabis; Cocaine; Diazepam; Heroin Dependence; Humans; Male | 1986 |
Metabolic mapping of the cerebral effects of abused drugs.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Deoxy Sugars; Deoxyglucose; Diazepam; Humans; | 1986 |
Benzodiazepine antagonist, CGS-8216, in diazepam- or pentobarbital-dependent and non-dependent rats.
Topics: Animals; Arousal; Diazepam; Dose-Response Relationship, Drug; Female; Flumazenil; Pentobarbital; Pyr | 1986 |
Effects of Ro 15-1788 and CGS 8216 in diazepam-dependent baboons.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Flumazenil; Male; Papio; Pyrazoles; Substance W | 1987 |
Apparent lesser physical dependence potential of nor-diazepam compared to diazepam in the rat.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Male; Nordazepam; Rats; Rats, Inbred Strains; S | 1987 |
Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs.
Topics: Analysis of Variance; Animals; Diazepam; Dogs; Flumazenil; Nordazepam; Oxazepam; Pyrazoles; Seizures | 1988 |
A simple and rapid method of inducing physical dependence with benzodiazepines in mice.
Topics: Animals; Benzodiazepines; Diazepam; Flumazenil; Injections, Intraperitoneal; Male; Mice; Mice, Inbre | 1988 |
Withdrawal from diazepam substitutes for the discriminative stimulus properties of pentylenetetrazol.
Topics: Animals; Diazepam; Discrimination Learning; Disease Models, Animal; Flumazenil; Male; Pentylenetetra | 1988 |
A personal story.
Topics: Alcoholism; Diazepam; Female; Humans; Nurses; Professional Impairment; Substance-Related Disorders | 1988 |
The seeking and liking potentials of alprazolam.
Topics: Adult; Alprazolam; Diazepam; Female; Humans; Male; Substance Withdrawal Syndrome; Substance-Related | 1988 |
Cross-physical dependence of several drugs in methaqualone-dependent rats.
Topics: Animals; Barbital; Diazepam; Ethanol; Male; Methaqualone; Pentobarbital; Postural Balance; Psychomot | 1988 |
[A case of dihydrocodeine and oxazolam abuse in which physical dependence on both drugs].
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Codeine; Diazepam; Humans; Male; Middle Age | 1988 |
Valium use and abuse by methadone maintenance clients.
Topics: Adult; Diazepam; Drug Synergism; Humans; Male; Methadone; Opioid-Related Disorders; Self Medication; | 1987 |
Relative abuse of diazepam and oxazepam: prescription forgeries and theft/loss reports in Sweden.
Topics: Cross-Sectional Studies; Depressive Disorder; Diazepam; Drug and Narcotic Control; Drug Prescription | 1986 |
Analysis of drug involvement in traffic fatalities in Alabama.
Topics: Accidents, Traffic; Alabama; Cannabinoids; Dextropropoxyphene; Diazepam; Ethanol; Humans; Methaqualo | 1986 |
Ginger: inhibition of thromboxane synthetase and stimulation of prostacyclin: relevance for medicine and psychiatry.
Topics: Condiments; Diazepam; Epoprostenol; Humans; Substance-Related Disorders; Thromboxane-A Synthase; Thr | 1986 |
[Physical dependence liability test of 4-(o-benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016) in rats].
Topics: Animals; Antidepressive Agents; Barbiturates; Benzhydryl Compounds; Body Weight; Codeine; Diazepam; | 1987 |
My little yellow wonder pill.
Topics: Anxiety; Diazepam; Female; Humans; Substance-Related Disorders | 1987 |
Physical dependence capacity of brotizolam in rhesus monkeys. 1st communication: primary dependence studies.
Topics: Animals; Azepines; Diazepam; Hypnotics and Sedatives; Macaca mulatta; Motor Activity; Psychomotor Pe | 1986 |
Physical dependence capacity of brotizolam in rhesus monkeys. 2nd communication: primary dependence and barbital substitution.
Topics: Animals; Azepines; Barbital; Barbiturates; Body Weight; Diazepam; Female; Hypnotics and Sedatives; M | 1986 |
The syndrome of anticholinergic intoxication.
Topics: Aged; Child; Diazepam; Humans; Medical History Taking; Parasympatholytics; Patient Education as Topi | 1986 |
Diazepam-induced amnesia: a neuropharmacological model of an "organic amnestic syndrome".
Topics: Adult; Amnesia; Attention; Diazepam; Dose-Response Relationship, Drug; Female; Humans; Male; Memory; | 1987 |
The effects of food deprivation on the self-administration of psychoactive drugs.
Topics: Animals; Cocaine; Dextroamphetamine; Diazepam; Food Deprivation; Macaca mulatta; Male; Nicotine; Per | 1987 |
Abuse liability of triazolam: experimental measurements in animals and humans.
Topics: Animals; Diazepam; Drug Tolerance; Humans; Male; Papio; Pentobarbital; Psychomotor Performance; Self | 1987 |
Dependence potential of the benzodiazepines: use of animal models for assessment.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Diazepam; Disease Models, Animal; | 1985 |
Blood pressure response to Ro15-1788, a benzodiazepine antagonist.
Topics: Animals; Benzodiazepinones; Blood Pressure; Cats; Convulsants; Diazepam; Drug Tolerance; Flumazenil; | 1985 |
Responsibilities of prescribing.
Topics: Adult; Amitriptyline; Diazepam; Humans; Male; Malpractice; Substance-Related Disorders; Tennessee | 1985 |
Drug addiction and the newborn.
Topics: Amphetamine; Antipsychotic Agents; Barbiturates; Cannabis; Child Welfare; Chlorpromazine; Diazepam; | 1973 |
[Surreptitious acquisition of medical prescriptions. Criminologic studies on drugs and deliquency].
Topics: Adolescent; Adult; Central Nervous System Stimulants; Criminology; Deception; Diazepam; Drug and Nar | 1974 |
Editorial: Drugs for anxiety.
Topics: Adolescent; Adult; Aged; Anxiety; Diazepam; Drug Prescriptions; Female; Hospitals, Psychiatric; Huma | 1974 |
Relative safety of self inflicted overdose with relatively newer medications.
Topics: Adult; Depression; Diazepam; Female; Humans; Lethal Dose 50; Metronidazole; Penicillin V; Substance- | 1973 |
[A case of valium withdrawal with grand mal attacks. A case report on valium abuse and valium addiction].
Topics: Adult; Diazepam; Epilepsy, Tonic-Clonic; Humans; Male; Substance Withdrawal Syndrome; Substance-Rela | 1974 |
[Voluntary detoxification therapy of young drug addicts in a medical clinic (author's transl)].
Topics: Adult; Alcoholism; Barbiturates; Cannabis; Diazepam; Drug Combinations; Drug Therapy, Combination; F | 1974 |
Infant of the addicted mother.
Topics: Chlorpromazine; Diazepam; Female; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Disea | 1973 |
Letter: Drugs for anxiety.
Topics: Anxiety; Diazepam; Humans; Substance-Related Disorders | 1974 |
The concentrations of diazepam and its metabolites in the plasma after an acute and chronic administration.
Topics: Anxiety Disorders; Chromatography, Gas; Diazepam; Humans; Methylation; Microsomes, Liver; Oxazepam; | 1974 |
Sedative-hypnotic dependence.
Topics: Attitude of Health Personnel; Attitude to Health; Diazepam; Dose-Response Relationship, Drug; Drug P | 1974 |
[Intense pentazocine abstinence syndrome. Treatment of a clinical case].
Topics: Administration, Oral; Adult; Butyrophenones; Diazepam; Drug Evaluation; Female; Haloperidol; Humans; | 1974 |
Temporal lobe epilepsy due to drug withdrawal.
Topics: Barbiturates; Diazepam; Electroencephalography; Epilepsy, Temporal Lobe; Female; Humans; Middle Aged | 1972 |
Newborn infants of mothers on methadone maintenance.
Topics: Body Weight; Camphor; Diazepam; Female; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, D | 1974 |
[Treatment of acute incidents in drug addiction].
Topics: Apnea; Ascorbic Acid; Coma; Diazepam; Drug Combinations; Humans; Psychomotor Disorders; Psychoses, S | 1972 |
Dependence liability of several sedative-hypnotic agents evaluated in monkeys.
Topics: Animals; Anthracenes; Barbiturates; Benzazepines; Catheterization; Chlordiazepoxide; Chloroform; Chl | 1973 |
[Primary valium dependence in a juvenile].
Topics: Adolescent; Age Factors; Diazepam; Female; Humans; Phenothiazines; Substance Withdrawal Syndrome; Su | 1972 |
[Tolerance and physical dependence producing liability of doxepin].
Topics: Amitriptyline; Animals; Body Weight; Diazepam; Dibenzoxepins; Drug Resistance; Humans; Imipramine; M | 1972 |
Prescription of psychotropic drugs by general practitioners. 1. General.
Topics: Adjustment Disorders; Adolescent; Adult; Aged; Alcoholism; Antidepressive Agents; Anxiety Disorders; | 1973 |
Psychotropic drugs in use today. The role of diazepam in medical practice.
Topics: Anxiety Disorders; Chlordiazepoxide; Depression; Diazepam; Drug Interactions; Drug Utilization; Fami | 1973 |
Acute drug poisoning in the adult.
Topics: Adult; Amphetamine; Antidepressive Agents; Cocaine; Diazepam; Diphenhydramine; Diuresis; Emergency S | 1973 |
Dermographism, erythema, and flare: clinical signs of drug overdose in the comatose patient.
Topics: Adult; Alcoholic Intoxication; Barbiturates; Bromides; Coma; Diagnosis, Differential; Diazepam; Eryt | 1973 |
Letter: Prescribing hypnotic and anti-anxiety drugs.
Topics: Chlordiazepoxide; Diazepam; Drug Prescriptions; Humans; Hypnotics and Sedatives; Meprobamate; Pentob | 1973 |
Narcotic poisoning: an epidemic disease.
Topics: Diazepam; Glucose; Hospitalization; Humans; Hyperglycemia; Methadone; Myelitis, Transverse; Myoglobi | 1973 |
[Fatal intoxication of a young drug addict with diazepam (author's transl)].
Topics: Adolescent; Alcoholic Intoxication; Autopsy; Diazepam; Humans; Hypothermia; Lethal Dose 50; Male; Su | 1973 |
[Screening procedure for barbital type physical dependence liability of psychotropic drugs in mice].
Topics: Amitriptyline; Animals; Barbiturates; Behavior, Animal; Benzazepines; Benzodiazepinones; Body Weight | 1973 |
Late presentation of drug withdrawal symptoms in newborns.
Topics: Birth Weight; Camphor; Diazepam; Female; Gestational Age; Heroin Dependence; Humans; Infant; Infant, | 1974 |
Seizures in newborn infants.
Topics: Birth Injuries; Brain; Calcium; Diazepam; Gluconates; Glucose; Humans; Hypocalcemia; Hypoxia; Infant | 1974 |
Letter: The dangers of diazepam, a street drug.
Topics: Diazepam; Humans; Substance-Related Disorders | 1974 |
Narcotic withdrawal in the newborn infant.
Topics: Diazepam; Female; Fetus; Heroin Dependence; Humans; Infant, Newborn; Infant, Newborn, Diseases; Mate | 1974 |
Born with a habit. Infants of drug-addicted mothers.
Topics: Abnormalities, Drug-Induced; Adult; Age Factors; Barbiturates; Camphor; Chlorpromazine; Codeine; Dia | 1974 |
Letter: Psychotropic drugs in addiction.
Topics: Biogenic Amines; Diazepam; Humans; Hypothalamus; Substance-Related Disorders | 1974 |
[Acute psychiatric complications due to drug abuse and their therapy].
Topics: Adolescent; Diazepam; Humans; Injections, Intravenous; Levallorphan; Morphine Dependence; Nalorphine | 1972 |
Chloroformism--a new case of a bad old habit.
Topics: Adult; Chloroform; Diazepam; Humans; Male; Substance-Related Disorders | 1972 |
[Drug dependence and current status of drug abuse].
Topics: Chlordiazepoxide; Diazepam; Humans; Japan; Meprobamate; Quinazolines; Substance-Related Disorders | 1972 |
Diazepam (Valium) for neonatal narcotic withdrawal: a question of safety.
Topics: Bilirubin; Binding Sites; Diazepam; Drug Interactions; Female; Humans; Infant, Newborn; Infant, Newb | 1972 |
Tranquilizer control.
Topics: Age Factors; Attitude of Health Personnel; Diazepam; Drug and Narcotic Control; Drug Utilization; Hu | 1972 |
[Emergency treatment and technic of detoxification in juvenile drug addicts].
Topics: Amphetamine; Barbiturates; Cannabis; Chlormethiazole; Cocaine; Diazepam; Emergencies; Humans; Lyserg | 1972 |
ECT in LSD psychosis. a report of three cases.
Topics: Chlordiazepoxide; Chlorpromazine; Diazepam; Electroconvulsive Therapy; Humans; Lysergic Acid Diethyl | 1971 |
A clinical view of the amphetamines.
Topics: Amphetamine; Appetite Depressants; Central Nervous System Diseases; Depression; Diazepam; Hospitaliz | 1971 |
Diazepam, alcohol, and barbiturate abuse.
Topics: Adult; Alcoholism; Barbiturates; Diazepam; Female; Humans; Substance-Related Disorders | 1971 |
[Use and abuse of benzodiazepines].
Topics: Anxiety Disorders; Diazepam; Humans; Substance-Related Disorders | 1971 |
[Medical facts must be brought up, nationally and internationally].
Topics: Chlordiazepoxide; Diazepam; Dronabinol; Drug and Narcotic Control; Hallucinogens; Heroin; Humans; Le | 1971 |
[Misuse of bezodiazepin derivatives in alcoholics].
Topics: Alcoholism; Chlordiazepoxide; Diazepam; Humans; Substance-Related Disorders | 1966 |
Stramonium psychodelia.
Topics: Adolescent; Adult; Datura stramonium; Diazepam; Hallucinogens; Humans; Male; Phenytoin; Pilocarpine; | 1969 |
Diazepam, nitrazepam and the N.H.S.
Topics: Chlordiazepoxide; Diazepam; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders | 1970 |
A new method for treatment of barbiturate dependence.
Topics: Barbiturates; Chlordiazepoxide; Diazepam; Heroin; Humans; Meprobamate; Pentobarbital; Phenobarbital; | 1970 |
[Slight abstinence symptoms].
Topics: Adult; Analgesics; Diazepam; Female; Humans; Phenobarbital; Substance Withdrawal Syndrome; Substance | 1970 |
[Drug dependence and addiction among patients of the Vienna Psychiatric-Neurological University Hospital with special reference to psychotropic drugs].
Topics: Analgesics; Antidepressive Agents; Antitussive Agents; Austria; Barbiturates; Cannabis; Chlordiazepo | 1970 |
[Drug abuse and addiction to diazepam].
Topics: Anxiety; Delirium; Depression; Diazepam; Humans; Substance Withdrawal Syndrome; Substance-Related Di | 1970 |
Drug interactions with anticoagulants.
Topics: Acetaminophen; Animals; Anti-Bacterial Agents; Anticoagulants; Ascorbic Acid; Barbiturates; Blood Co | 1970 |
Basic considerations in the psychotherapy of the depressed suicidal patient.
Topics: Adaptation, Psychological; Chlordiazepoxide; Countertransference; Crisis Intervention; Depression; D | 1971 |
[Abuse of hypnotics and sedatives by young addicts].
Topics: Adolescent; Adult; Barbiturates; Diazepam; Female; Humans; Hypnotics and Sedatives; Morphine; Necros | 1971 |
[Drug dependence--a clinical and theoretical evaluation].
Topics: Adolescent; Adult; Barbiturates; Cannabis; Diazepam; Dibenzazepines; Humans; Meprobamate; Personalit | 1971 |
[Use and misuse of benzodiazepine derivatives].
Topics: Animals; Antidepressive Agents; Anxiety Disorders; Chlordiazepoxide; Diazepam; Humans; Substance-Rel | 1971 |
[Use of valium in clinical psychiatry].
Topics: Alcoholism; Diazepam; Humans; Intellectual Disability; Psychotic Disorders; Substance-Related Disord | 1967 |
Use of diazepam in hallucinogenic drug crises.
Topics: Adolescent; Adult; Amphetamine; Diazepam; Female; Hallucinogens; Humans; Lysergic Acid Diethylamide; | 1968 |
The effect of antidepressants and "tranquilizers" on the response of mice to ethanol.
Topics: Accidents, Traffic; Amitriptyline; Animals; Antidepressive Agents; Chlorpromazine; Coma; Desipramine | 1968 |
[Therapy of anxiety, mental anguish and sleeplessness. 4. Drug abuse and accidents].
Topics: Accidents, Traffic; Barbiturates; Chlordiazepoxide; Chlormethiazole; Diazepam; Drug Synergism; Ethan | 1969 |
[Therapy of anxiety, mental anguish and sleeplessness. 5. Abuse of diazepam?].
Topics: Chlordiazepoxide; Diazepam; Humans; Meprobamate; Substance Withdrawal Syndrome; Substance-Related Di | 1969 |
[Addiction to and abuse of tranquilizers].
Topics: Chlordiazepoxide; Diazepam; Humans; Meprobamate; Substance-Related Disorders; Tranquilizing Agents | 1965 |
[A case of Valium withdrawal delirium].
Topics: Adult; Delusions; Diazepam; Hallucinations; Humans; Male; Substance Withdrawal Syndrome; Substance-R | 1965 |