diazepam has been researched along with Cerebral Ischemia in 26 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The protective effect and mechanism of diazepam on ischemia neurons during cerebral ischemia and reperfusion were studied." | 7.71 | Effect of diazepam on the contents of amino acids and free radical during ischemia/reperfusion injury. ( Hu, B; Mei, Y; Qiu, X; Sun, S; Tong, E; Wei, G, 2001) |
| " The present study was undertaken to determine whether diazepam, a potent, centrally penetrating GABAmimetic, alone or in combination with insulin, could mitigate postischemic seizures or regional selective neuronal necrosis and infarction." | 7.68 | Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin. ( Auer, RN; Voll, CL, 1991) |
| "5 mmol/kg), either alone or in combination with diazepam (DZ), on ischemia-induced hippocampal cell death." | 5.30 | Magnesium chloride alone or in combination with diazepam fails to prevent hippocampal damage following transient forebrain ischemia. ( Favero-Filho, LA; Giordani, F; Lepri, ER; Milani, H, 1999) |
| "Although diazepam provides limited long term neuroprotection, it may be useful for expanding the therapeutic time window after stroke by delaying neuronal death." | 3.74 | Diazepam delays the death of hippocampal CA1 neurons following global ischemia. ( Corbett, D; Langdon, KD; Larsen, J, 2008) |
| "The protective effect and mechanism of diazepam on ischemia neurons during cerebral ischemia and reperfusion were studied." | 3.71 | Effect of diazepam on the contents of amino acids and free radical during ischemia/reperfusion injury. ( Hu, B; Mei, Y; Qiu, X; Sun, S; Tong, E; Wei, G, 2001) |
| " Mongolian gerbils were subjected to transient forebrain ischemia for 5 min by occlusion of the carotid arteries and then administered diazepam (10 mg/kg i." | 3.69 | Postischemic diazepam is neuroprotective in the gerbil hippocampus. ( Bishop, M; Carter, ML; Huff, RA; Schwartz, RD; Yu, X, 1994) |
| " The present study was undertaken to determine whether diazepam, a potent, centrally penetrating GABAmimetic, alone or in combination with insulin, could mitigate postischemic seizures or regional selective neuronal necrosis and infarction." | 3.68 | Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin. ( Auer, RN; Voll, CL, 1991) |
| "Flumazenil treatment before BCAO reduced ischaemic neuronal damage exacerbated by benzodiazepine tolerance (P<0." | 1.38 | Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance. ( Furuya, H; Inoue, S; Iwata, M; Kawaguchi, M, 2012) |
| "The dog was presented with seizures and neurological deficits consistent with a left brainstem and multifocal/diffuse forebrain lesion after an asymptomatic interval of 72 hours following the ischaemic event." | 1.35 | Sequential magnetic resonance imaging changes after suspected global brain ischaemia in a dog. ( Flegel, T; Oechtering, G; Timm, K, 2008) |
| "We used an in vitro model of cerebral ischemia (oxygen-glucose deprivation) to examine changes in [Cl-]i and GABA(A) receptor-mediated responses in hippocampal slices from adult rats." | 1.32 | Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam. ( Galeffi, F; George, A; Pond, BB; Sah, R; Schwartz-Bloom, RD, 2004) |
| "When diazepam was included in the reoxygenation buffer, ATP levels recovered completely by 3 h after OGD." | 1.31 | Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia. ( Galeffi, F; Schwartz-Bloom, RD; Sinnar, S, 2000) |
| "Diazepam (10 mg/kg) was administered to two groups of gerbils at 30 and 90 min following a 5-min ischemic insult." | 1.30 | Diazepam-induced neuroprotection: dissociating the effects of hypothermia following global ischemia. ( Corbett, D; Dooley, P; Dowden, J; Reid, C, 1999) |
| "5 mmol/kg), either alone or in combination with diazepam (DZ), on ischemia-induced hippocampal cell death." | 1.30 | Magnesium chloride alone or in combination with diazepam fails to prevent hippocampal damage following transient forebrain ischemia. ( Favero-Filho, LA; Giordani, F; Lepri, ER; Milani, H, 1999) |
| "Diazepam was microinjected into the CA1 hippocampus 1 and 2 hr following ischemia, and rats remained normothermic." | 1.29 | Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum. ( Hayden-Hixson, DM; Katzman, MR; Perry, JM; Schwartz, RD; Yu, X, 1995) |
| " The effective dosage of the drugs were 20-40 mg/kg in pentobarbital, 10-20 mg/kg in diazepam, and 12." | 1.27 | [Treatable ischemic neuronal damage in the gerbil hippocampus]. ( Kirino, T; Sano, K; Tamura, A; Tomukai, N, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (23.08) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 10 (38.46) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nochi, R | 1 |
| Kaneko, J | 1 |
| Okada, N | 1 |
| Terazono, Y | 1 |
| Matani, A | 1 |
| Hisatsune, T | 1 |
| Corbett, D | 2 |
| Larsen, J | 1 |
| Langdon, KD | 1 |
| Fukuhara, A | 1 |
| Nakajima, H | 1 |
| Miyamoto, Y | 1 |
| Inoue, K | 1 |
| Kume, S | 1 |
| Lee, YH | 1 |
| Noda, M | 1 |
| Uchiyama, S | 1 |
| Shimamoto, S | 1 |
| Nishimura, S | 1 |
| Ohkubo, T | 1 |
| Goto, Y | 1 |
| Takeuchi, T | 1 |
| Inui, T | 1 |
| Iwata, M | 1 |
| Inoue, S | 1 |
| Kawaguchi, M | 1 |
| Furuya, H | 1 |
| Kuhmonen, J | 1 |
| Lukkarinen, J | 1 |
| Gröhn, O | 1 |
| Jolkkonen, J | 1 |
| Sivenius, J | 1 |
| Machado, C | 1 |
| Galeffi, F | 2 |
| Sah, R | 1 |
| Pond, BB | 1 |
| George, A | 1 |
| Schwartz-Bloom, RD | 2 |
| Davies, LM | 1 |
| MacLellan, CL | 1 |
| Corbett, DR | 1 |
| Colbourne, F | 1 |
| Aerden, LA | 1 |
| Kessels, FA | 1 |
| Rutten, BP | 1 |
| Lodder, J | 1 |
| Steinbusch, HW | 1 |
| Ricci, L | 1 |
| Valoti, M | 1 |
| Sgaragli, G | 1 |
| Frosini, M | 1 |
| Timm, K | 1 |
| Flegel, T | 1 |
| Oechtering, G | 1 |
| Kawajiri, S | 1 |
| Kojima, H | 1 |
| Akashi, A | 1 |
| Busch, KT | 1 |
| Schulz, H | 1 |
| Schwartz, RD | 2 |
| Yu, X | 2 |
| Katzman, MR | 1 |
| Hayden-Hixson, DM | 1 |
| Perry, JM | 1 |
| Huff, RA | 1 |
| Carter, ML | 1 |
| Bishop, M | 1 |
| Hall, ED | 1 |
| Fleck, TJ | 1 |
| Oostveen, JA | 1 |
| Dowden, J | 1 |
| Reid, C | 1 |
| Dooley, P | 1 |
| Milani, H | 1 |
| Lepri, ER | 1 |
| Giordani, F | 1 |
| Favero-Filho, LA | 1 |
| Sinnar, S | 1 |
| Hu, B | 1 |
| Mei, Y | 1 |
| Wei, G | 1 |
| Qiu, X | 1 |
| Sun, S | 1 |
| Tong, E | 1 |
| Bakhur, VT | 1 |
| Zaikin, VS | 1 |
| Voronin, TS | 1 |
| Johansen, FF | 1 |
| Diemer, NH | 1 |
| Voll, CL | 1 |
| Auer, RN | 1 |
| Ahlemeyer, B | 1 |
| Krieglstein, J | 1 |
| Roquefeuil, B | 1 |
| Kirino, T | 1 |
| Tamura, A | 1 |
| Tomukai, N | 1 |
| Sano, K | 1 |
26 other studies available for diazepam and Cerebral Ischemia
| Article | Year |
|---|---|
Diazepam treatment blocks the elevation of hippocampal activity and the accelerated proliferation of hippocampal neural stem cells after focal cerebral ischemia in mice.
Topics: Animals; Brain Ischemia; Cell Proliferation; Diazepam; Disease Models, Animal; Electrophysiology; GA | 2013 |
Diazepam delays the death of hippocampal CA1 neurons following global ischemia.
Topics: Animals; Anticonvulsants; Body Temperature; Brain Ischemia; Cell Count; Diazepam; Excitatory Postsyn | 2008 |
Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Brain Ischemia; CA1 Region, Hippocampal; Diazepam; Di | 2012 |
Effects of diazepam and flumazenil on forebrain ischaemia in a rat model of benzodiazepine tolerance.
Topics: Analysis of Variance; Animals; Benzodiazepines; Brain Ischemia; Diazepam; Disease Models, Animal; Dr | 2012 |
Diazepam does not reduce infarct size in rats subjected to transient occlusion of the middle cerebral artery when normothermia is maintained.
Topics: Animals; Arterial Occlusive Diseases; Body Temperature; Brain Infarction; Brain Ischemia; Cerebral A | 2002 |
Randomized clinical trial of magnesium, diazepam, or both after out-of-hospital cardiac arrest.
Topics: Animals; Brain Ischemia; Diazepam; Dogs; Drug Therapy, Combination; Heart Arrest; Humans; Hypothermi | 2003 |
Changes in intracellular chloride after oxygen-glucose deprivation of the adult hippocampal slice: effect of diazepam.
Topics: Action Potentials; Animals; Brain Ischemia; Calcium; Cell Hypoxia; Chlorides; Diazepam; GABA Antagon | 2004 |
Post-ischemic diazepam does not reduce hippocampal CA1 injury and does not improve hypothermic neuroprotection after forebrain ischemia in gerbils.
Topics: Animals; Anticonvulsants; Body Temperature; Brain Ischemia; Combined Modality Therapy; Diazepam; Fem | 2004 |
Diazepam reduces brain lesion size in a photothrombotic model of focal ischemia in rats.
Topics: Animals; Anticonvulsants; Body Weight; Brain Ischemia; Cerebral Infarction; Diazepam; Disease Models | 2004 |
Neuroprotection afforded by diazepam against oxygen/glucose deprivation-induced injury in rat cortical brain slices.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Flumazenil; GA | 2007 |
Sequential magnetic resonance imaging changes after suspected global brain ischaemia in a dog.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents; Anticonvulsants; Apnea; Bradycardia; Brain; Brain Isc | 2008 |
[A comparison of the effects of baclofen and some other muscle relaxants on alpha-rigidity in rats].
Topics: Animals; Baclofen; Brain Ischemia; Chlordiazepoxide; Dantrolene; Decerebrate State; Diazepam; Male; | 1984 |
[The acute psychiatric emergency].
Topics: Acute Disease; Aged; Alcoholism; Amitriptyline; Brain Ischemia; Cognition Disorders; Consciousness D | 1981 |
Diazepam, given postischemia, protects selectively vulnerable neurons in the rat hippocampus and striatum.
Topics: Animals; Brain Ischemia; Corpus Striatum; Diazepam; Hippocampus; Male; Neurons; Neuroprotective Agen | 1995 |
Postischemic diazepam is neuroprotective in the gerbil hippocampus.
Topics: Animals; Body Temperature; Brain Ischemia; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Het | 1994 |
Comparative neuroprotective properties of the benzodiazepine receptor full agonist diazepam and the partial agonist PNU-101017 in the gerbil forebrain ischemia model.
Topics: Animals; Brain Ischemia; Diazepam; GABA Agonists; GABA-A Receptor Agonists; Gerbillinae; Hippocampus | 1998 |
Diazepam-induced neuroprotection: dissociating the effects of hypothermia following global ischemia.
Topics: Animals; Anti-Anxiety Agents; Body Temperature Regulation; Brain Ischemia; Diazepam; Drug Evaluation | 1999 |
Magnesium chloride alone or in combination with diazepam fails to prevent hippocampal damage following transient forebrain ischemia.
Topics: Animals; Brain Ischemia; Diazepam; Dose-Response Relationship, Drug; Drug Administration Schedule; D | 1999 |
Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Cytochrome c Group; Cytosol; Diazepam; Glucose; Hip | 2000 |
Effect of diazepam on the contents of amino acids and free radical during ischemia/reperfusion injury.
Topics: Amino Acids; Animals; Brain Ischemia; Diazepam; Free Radicals; GABA Modulators; Male; Rats; Rats, Wi | 2001 |
[Use of seduxen to arrest acute cochleovestibular syndromes in transient cerebral disorders].
Topics: Acute Disease; Adult; Aged; Basilar Artery; Brain Ischemia; Cerebrovascular Disorders; Cochlear Nerv | 1978 |
Enhancement of GABA neurotransmission after cerebral ischemia in the rat reduces loss of hippocampal CA1 pyramidal cells.
Topics: Animals; Arousal; Brain Ischemia; Cell Count; Cell Survival; Diazepam; Dose-Response Relationship, D | 1991 |
Postischemic seizures and necrotizing ischemic brain damage: neuroprotective effect of postischemic diazepam and insulin.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Diazepam; Insulin; Male; Necrosis; Nervous System; R | 1991 |
Testing drug effects against hypoxic damage of cultured neurons during long-term recovery.
Topics: Adenosine Triphosphate; Animals; Anticonvulsants; Brain Ischemia; Cell Count; Cell Survival; Cells, | 1989 |
[Cerebral ischemia, anesthetic agents and cerebral metabolic protection].
Topics: Alfaxalone Alfadolone Mixture; Anesthetics; Barbiturates; Brain; Brain Ischemia; Diazepam; Etomidate | 1987 |
[Treatable ischemic neuronal damage in the gerbil hippocampus].
Topics: Animals; Brain Ischemia; Diazepam; Gerbillinae; Hippocampus; Humans; Imidazoles; Pentobarbital | 1986 |