diazepam has been researched along with Carbon Tetrachloride Poisoning in 4 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Carbon Tetrachloride Poisoning: Poisoning that results from ingestion, injection, inhalation, or skin absorption of CARBON TETRACHLORIDE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " When animals are pretreated with this hepatotoxic agent, a significant prolongation in plasma half-life of diazepam is observed, due more to an increase in volume of distribution rather than to a decrease in clearance." | 1.28 | Pharmacokinetics of diazepam in the rat: influence of an experimentally induced hepatic injury. ( Diaz-Garcia, JM; Fos Galve, D; Oliver-Botana, J, 1991) |
| " The bioavailability (F) values of I at dosage levels 0." | 1.27 | Nonlinear bioavailability of metoclopramide in the rat: evidence for saturable first-pass metabolism. ( Axelson, JE; Kapil, RP; Ongley, R; Price, JD, 1984) |
| " FCE 20700 (5 micrograms/ml, sc) did not change, by itself, either SGPT or diazepam pharmacokinetic parameters, but significantly antagonized the changes induced by CC14 (SGPT: 45." | 1.27 | Carbon tetrachloride-induced pharmacokinetic changes of diazepam in rats are reduced by a stable analogue of prostaglandin E2 : FCE 20700. ( Ceserani, R; Costa, G; Padovano, I; Puzzolo, D; Saija, A, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kapil, RP | 1 |
| Axelson, JE | 1 |
| Ongley, R | 1 |
| Price, JD | 1 |
| Mikhaĭlenko, AA | 1 |
| Beliakov, VA | 1 |
| Sinitsyn, LN | 1 |
| Kolpashchikova, IF | 1 |
| Shidlovskiĭ, AS | 1 |
| Diaz-Garcia, JM | 1 |
| Oliver-Botana, J | 1 |
| Fos Galve, D | 1 |
| Saija, A | 1 |
| Padovano, I | 1 |
| Puzzolo, D | 1 |
| Ceserani, R | 1 |
| Costa, G | 1 |
4 other studies available for diazepam and Carbon Tetrachloride Poisoning
| Article | Year |
|---|---|
Nonlinear bioavailability of metoclopramide in the rat: evidence for saturable first-pass metabolism.
Topics: Animals; Biological Availability; Carbon Tetrachloride Poisoning; Diazepam; Hepatectomy; Kidney; Kin | 1984 |
[Use of sodium oxybutyrate and diazepam for removing the psychomotor excitation in hepatic coma].
Topics: Animals; Carbon Tetrachloride Poisoning; Cats; Diazepam; Drug Evaluation; Drug Evaluation, Preclinic | 1980 |
Pharmacokinetics of diazepam in the rat: influence of an experimentally induced hepatic injury.
Topics: Administration, Oral; Animals; Blood Proteins; Carbon Tetrachloride Poisoning; Diazepam; Erythrocyte | 1991 |
Carbon tetrachloride-induced pharmacokinetic changes of diazepam in rats are reduced by a stable analogue of prostaglandin E2 : FCE 20700.
Topics: Alanine Transaminase; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1985 |