diazepam has been researched along with Brain Neoplasms in 41 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells." | 7.71 | Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line. ( Lavicka, J; Mirossay, A; Mirossay, L; Mojzis, J; Sarisský, M; Sulla, I, 2001) |
| "The combination of lonidamine and diazepam--drugs that target two distinct mitochondrial sites involved in cellular energy metabolism--potentiates the effects of the individual drugs and may prove useful in the treatment of human glioblastomas." | 7.70 | Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment. ( Bourgeois, Y; Bras Gonçalves, R; Dutrillaux, B; Miccoli, L; Oudard, S; Poirson-Bichat, F; Poupon, MF; Sureau, F, 1998) |
| "Five milligrams of intravenous diazepam given prior to contrast media injection statistically significantly reduced the incidence of contrast media-associated seizures from 16% to 2% in a prospective, randomized series of glioma patients." | 7.67 | Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography. ( Bigelow, RH; Hayman, LA; Lepke, RA; Libshitz, HI; Pagani, JJ, 1984) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 7.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| " The LND-diazepam at the used dosing schedule did not show a complete or partial response." | 6.71 | Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme. ( Andrieu, JM; Banu, E; Carpentier, A; Celerier, D; Delattre, JY; Dutrillaux, B; Fauchon, F; Oudard, S; Poupon, MF, 2003) |
| "Diazepam has potential to be a lead for new drugs in GBM therapy because of its antitumor activity." | 5.39 | Diazepam inhibits proliferation of human glioblastoma cells through triggering a G0/G1 cell cycle arrest. ( Cao, L; Chen, J; Hu, J; Lin, J; Lin, S; Mao, L; Ouyang, Y; Yan, G; Yang, X; Zhang, H; Zhou, Y; Zhu, W, 2013) |
| "When hypericin was combined with diazepam, photocytotoxicity was increased in U-87 MG cells and primary cultures unlike U373 MG cells." | 5.33 | Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells. ( Gajdos, M; Kocanová, S; Lavicka, J; Mirossay, A; Mirossay, L; Miskovsky, P; Mojzis, J; Sarissky, M; Sulla, I, 2005) |
| " Differentiated human neuroblastoma SH-SY5Y cells were exposed to acrylamide, lindane, parathion, paraoxon, phenytoin, diazepam or caffeine for 72 hours." | 3.74 | Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity. ( Blaauboer, B; Forsby, A, 2007) |
| " In this work, we sought to enhance cytotoxic effect of etoposide (VP-16) by a PBR ligand, diazepam (DZ) in U-87 MG human glioma cells." | 3.71 | Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line. ( Lavicka, J; Mirossay, A; Mirossay, L; Mojzis, J; Sarisský, M; Sulla, I, 2001) |
| "The combination of lonidamine and diazepam--drugs that target two distinct mitochondrial sites involved in cellular energy metabolism--potentiates the effects of the individual drugs and may prove useful in the treatment of human glioblastomas." | 3.70 | Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment. ( Bourgeois, Y; Bras Gonçalves, R; Dutrillaux, B; Miccoli, L; Oudard, S; Poirson-Bichat, F; Poupon, MF; Sureau, F, 1998) |
| "Five milligrams of intravenous diazepam given prior to contrast media injection statistically significantly reduced the incidence of contrast media-associated seizures from 16% to 2% in a prospective, randomized series of glioma patients." | 3.67 | Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography. ( Bigelow, RH; Hayman, LA; Lepke, RA; Libshitz, HI; Pagani, JJ, 1984) |
| "A therapeutic regimen is described for sedative, analgesic, and anti-emetic effect in patients receiving intra-arterial carmustine (BCNU) for malignant gliomas." | 3.67 | Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion. ( Klein, DS; Klein, PW; Mahaley, MS, 1986) |
| " The LND-diazepam at the used dosing schedule did not show a complete or partial response." | 2.71 | Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme. ( Andrieu, JM; Banu, E; Carpentier, A; Celerier, D; Delattre, JY; Dutrillaux, B; Fauchon, F; Oudard, S; Poupon, MF, 2003) |
| " Furthermore, total drug dosage requirements were measured and compared." | 2.67 | [Infusion or repetitive bolus injection? A clinical study of midazolam/fentanyl and diazepam/fentanyl combination anesthesia in neurosurgical operations]. ( Luger, TJ; Mair, P; Morawetz, R; Mutz, N; Stroschneider, E, 1990) |
| "Diazepam has potential to be a lead for new drugs in GBM therapy because of its antitumor activity." | 1.39 | Diazepam inhibits proliferation of human glioblastoma cells through triggering a G0/G1 cell cycle arrest. ( Cao, L; Chen, J; Hu, J; Lin, J; Lin, S; Mao, L; Ouyang, Y; Yan, G; Yang, X; Zhang, H; Zhou, Y; Zhu, W, 2013) |
| " dosing was followed by rapid elimination of the drug and was ineffective." | 1.35 | Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand. ( Beaudry, F; Berger, F; Falardeau, P; Farnet, CM; Gourdeau, H; McAlpine, JB; Ranger, M; Simard, B, 2008) |
| "When hypericin was combined with diazepam, photocytotoxicity was increased in U-87 MG cells and primary cultures unlike U373 MG cells." | 1.33 | Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells. ( Gajdos, M; Kocanová, S; Lavicka, J; Mirossay, A; Mirossay, L; Miskovsky, P; Mojzis, J; Sarissky, M; Sulla, I, 2005) |
| "Reported are three patients with ictal monoparesis of an arm." | 1.33 | Ictal monoparesis associated with lesions in the primary somatosensory area. ( Aoki, T; Hanakawa, T; Hitomi, T; Ikeda, A; Matsumoto, R; Miki, Y; Shibasaki, H; Shimohama, S; Tomimoto, H, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (65.85) | 18.7374 |
| 1990's | 4 (9.76) | 18.2507 |
| 2000's | 7 (17.07) | 29.6817 |
| 2010's | 2 (4.88) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Drljača, J | 1 |
| Popović, A | 1 |
| Bulajić, D | 1 |
| Stilinović, N | 1 |
| Vidičević Novaković, S | 1 |
| Sekulić, S | 1 |
| Milenković, I | 1 |
| Ninković, S | 1 |
| Ljubković, M | 1 |
| Čapo, I | 1 |
| Yan, N | 1 |
| Zheng, Y | 1 |
| Yang, C | 1 |
| Chen, J | 1 |
| Ouyang, Y | 1 |
| Cao, L | 1 |
| Zhu, W | 1 |
| Zhou, Y | 2 |
| Zhang, H | 1 |
| Yang, X | 1 |
| Mao, L | 1 |
| Lin, S | 1 |
| Lin, J | 1 |
| Hu, J | 1 |
| Yan, G | 1 |
| Alajbegović, A | 1 |
| Loga, N | 1 |
| Alajbegović, S | 1 |
| Suljić, E | 1 |
| Oudard, S | 3 |
| Carpentier, A | 1 |
| Banu, E | 1 |
| Fauchon, F | 1 |
| Celerier, D | 1 |
| Poupon, MF | 3 |
| Dutrillaux, B | 3 |
| Andrieu, JM | 1 |
| Delattre, JY | 1 |
| FOWLKS, EW | 1 |
| STRICKLAND, DA | 1 |
| PEIRSON, GA | 1 |
| Sarissky, M | 2 |
| Lavicka, J | 2 |
| Kocanová, S | 1 |
| Sulla, I | 2 |
| Mirossay, A | 2 |
| Miskovsky, P | 1 |
| Gajdos, M | 1 |
| Mojzis, J | 2 |
| Mirossay, L | 2 |
| Matsumoto, R | 1 |
| Ikeda, A | 1 |
| Hitomi, T | 1 |
| Aoki, T | 1 |
| Hanakawa, T | 1 |
| Miki, Y | 1 |
| Tomimoto, H | 1 |
| Shimohama, S | 1 |
| Shibasaki, H | 1 |
| Forsby, A | 1 |
| Blaauboer, B | 1 |
| Gourdeau, H | 1 |
| McAlpine, JB | 1 |
| Ranger, M | 1 |
| Simard, B | 1 |
| Berger, F | 1 |
| Beaudry, F | 1 |
| Farnet, CM | 1 |
| Falardeau, P | 1 |
| Zlobina, GP | 1 |
| Kondakova, LI | 1 |
| Mukhin, AG | 1 |
| Pagani, JJ | 2 |
| Hayman, LA | 2 |
| Bigelow, RH | 2 |
| Libshitz, HI | 2 |
| Lepke, RA | 2 |
| Wallace, S | 1 |
| Scherber, A | 1 |
| Richter, K | 1 |
| Partanen, VS | 1 |
| Soininen, H | 1 |
| Saksa, M | 1 |
| Riekkinen, P | 1 |
| Miccoli, L | 2 |
| Poirson-Bichat, F | 1 |
| Sureau, F | 1 |
| Bras Gonçalves, R | 1 |
| Bourgeois, Y | 1 |
| Zacchetti, O | 1 |
| Di Giovanni, T | 1 |
| Gemignani, F | 1 |
| Mancia, D | 1 |
| Terzano, MG | 1 |
| Hougaard, K | 1 |
| Oikawa, T | 1 |
| Sveinsdottir, E | 1 |
| Skinoj, E | 1 |
| Ingvar, DH | 1 |
| Lassen, NA | 1 |
| Endler, S | 1 |
| Müller, E | 1 |
| Faber, J | 2 |
| Tosovský, J | 2 |
| Hynek, K | 2 |
| Dusek, J | 1 |
| Oki, J | 1 |
| Itoh, J | 1 |
| Kusunoki, Y | 1 |
| Cho, K | 1 |
| Mair, P | 1 |
| Mutz, N | 1 |
| Stroschneider, E | 1 |
| Luger, TJ | 1 |
| Morawetz, R | 1 |
| Klein, DS | 1 |
| Klein, PW | 1 |
| Mahaley, MS | 1 |
| Weber, M | 2 |
| Tridon, P | 2 |
| Laxenaire, M | 1 |
| Arnould, G | 2 |
| Friedlander, WJ | 1 |
| Jain, KK | 1 |
| Parkin, JL | 1 |
| Tharp, BR | 1 |
| Wilkinson, HA | 1 |
| Masingue, M | 1 |
| Martin, JY | 1 |
| Tenser, RB | 1 |
| Corbett, JJ | 1 |
| Tyler, HR | 1 |
| Nicol, CF | 1 |
| Tutton, JC | 1 |
| Smith, BH | 1 |
| Hagimori, M | 1 |
| Loche, D | 1 |
| Repolt, J | 1 |
| Binnert, D | 1 |
| Mallecourt, J | 1 |
| Schmidt, D | 1 |
| Kommerell, G | 1 |
| Candia, O | 1 |
| Di Lupo, G | 1 |
| Fadeuilhe, A | 1 |
| Darcourt, G | 1 |
| Lavagna, J | 1 |
| Capdeville, C | 1 |
| Cossa, P | 1 |
4 reviews available for diazepam and Brain Neoplasms
| Article | Year |
|---|---|
[Targeting the gene of glucose metabolism for the treatment of advanced gliomas].
Topics: Antineoplastic Agents; Brain; Brain Neoplasms; Chromosome Deletion; Diazepam; Glioma; Glucose; Glyco | 1998 |
Epilepsy.
Topics: Adolescent; Animals; Barbiturates; Brain Neoplasms; Cell Membrane Permeability; Central Nervous Syst | 1968 |
Recent progress in epilepsy. Diagnostic procedures and treatment.
Topics: Anticonvulsants; Brain Neoplasms; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Temporal Lob | 1973 |
Advances in neurology.
Topics: Analgesics; Anticoagulants; Brain; Brain Neoplasms; Carbamazepine; Cerebrovascular Disorders; Contra | 1968 |
3 trials available for diazepam and Brain Neoplasms
| Article | Year |
|---|---|
Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Diazepam; Female; Glioblasto | 2003 |
Diazepam prophylaxis of contrast media-induced seizures during computed tomography of patients with brain metastases.
Topics: Aged; Brain Neoplasms; Clinical Trials as Topic; Contrast Media; Diazepam; Humans; Radiotherapy Dosa | 1983 |
[Infusion or repetitive bolus injection? A clinical study of midazolam/fentanyl and diazepam/fentanyl combination anesthesia in neurosurgical operations].
Topics: Adult; Anesthesia, Intravenous; Brain Neoplasms; Craniotomy; Diazepam; Fentanyl; Hemodynamics; Human | 1990 |
34 other studies available for diazepam and Brain Neoplasms
| Article | Year |
|---|---|
Diazepam diminishes temozolomide efficacy in the treatment of U87 glioblastoma cell line.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; | 2022 |
Functional and morphological effects of diazepam and midazolam on tumor vasculature in the 9L gliosarcoma brain tumor model using dynamic susceptibility contrast MRI: a comparative study.
Topics: Angiogenesis Inhibitors; Animals; Brain; Brain Neoplasms; Cerebrovascular Circulation; Contrast Medi | 2017 |
Diazepam inhibits proliferation of human glioblastoma cells through triggering a G0/G1 cell cycle arrest.
Topics: Antimetabolites; Benzimidazoles; Blotting, Western; Brain Neoplasms; Bromodeoxyuridine; Cell Cycle; | 2013 |
Characteristics of symptomatic epilepsy in patients with brain tumours.
Topics: Anticonvulsants; Brain Neoplasms; Carbamazepine; Diazepam; Epilepsy, Generalized; Female; Frontal Lo | 2009 |
CONTROL OF SPASTIC STATES IN NEUROLOGICAL PATIENTS WITH DIAZEPAM.
Topics: Biomedical Research; Brain Diseases; Brain Neoplasms; Central Nervous System Diseases; Diazepam; Dru | 1965 |
Diazepam enhances hypericin-induced photocytotoxicity and apoptosis in human glioblastoma cells.
Topics: Adult; Aged; Anthracenes; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Diazepam; Drug Interact | 2005 |
Ictal monoparesis associated with lesions in the primary somatosensory area.
Topics: Adult; Arm; Brain Damage, Chronic; Brain Neoplasms; Cerebral Angiography; Cerebral Veins; Diazepam; | 2005 |
Integration of in vitro neurotoxicity data with biokinetic modelling for the estimation of in vivo neurotoxicity.
Topics: Acrylamide; Animals; Anticonvulsants; Brain Neoplasms; Caffeine; Calcium Channels; Central Nervous S | 2007 |
Identification, characterization and potent antitumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Benzodiazepines; Brain Neoplasms; Cell Line, Tumor | 2008 |
[Benzodiazepine receptors of the mouse glioblastoma cell line: the anomalous effect of gamma-aminobutyric acid on diazepam binding].
Topics: Animals; Benzodiazepines; Brain Neoplasms; Cell Line; Cells, Cultured; Diazepam; gamma-Aminobutyric | 1982 |
Prophylactic diazepam in prevention of contrast media-associated seizures in glioma patients undergoing cerebral computed tomography.
Topics: Adolescent; Adult; Brain Neoplasms; Contrast Media; Diazepam; Drug Evaluation; Female; Glioma; Human | 1984 |
[The distribution of drugs between plasma, brain and cerebrospinal fluid in the human].
Topics: Blood-Brain Barrier; Brain; Brain Neoplasms; Carbamazepine; Diazepam; Humans; Lithium; Nordazepam; P | 1982 |
Electromyographic and nerve conduction findings in a patient with neuromyotonia, normocalcemic tetany and small-cell lung cancer.
Topics: Asbestosis; Blood Cell Count; Blood Circulation; Brain Neoplasms; Carbamazepine; Diazepam; Electromy | 1980 |
Potentiation of lonidamine and diazepam, two agents acting on mitochondria, in human glioblastoma treatment.
Topics: Animals; Anti-Anxiety Agents; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Diaz | 1998 |
Diazepam enhances etoposide-induced cytotoxicity in U-87 MG human glioma cell line.
Topics: Anticonvulsants; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; | 2001 |
[Use of EEG response following intravenous diazepam administration in the etiologic diagnosis of brain lesions].
Topics: Adult; Aged; Brain; Brain Neoplasms; Cerebrovascular Disorders; Diazepam; Electroencephalography; Fe | 1977 |
Regional cerebral blood flow in focal cortical epilepsy.
Topics: Adult; Aged; Brain Neoplasms; Cerebral Cortex; Cerebrovascular Circulation; Diazepam; Electroencepha | 1976 |
[Effect of intravenous diazepam (Faustan) on EEG focal disturbances].
Topics: Adolescent; Adult; Aged; Beta Rhythm; Brain Neoplasms; Cerebrovascular Disorders; Diazepam; Electroe | 1976 |
Factor analysis of EEG in healthy and diseased subjects.
Topics: Adolescent; Adult; Brain; Brain Neoplasms; Child; Diazepam; Electroencephalography; Female; Humans; | 1975 |
[Exacerbation of partial seizures in a case with heterotopic gray matter using antiepileptic drugs].
Topics: Brain; Brain Neoplasms; Carbamazepine; Child, Preschool; Choristoma; Diazepam; Electroencephalograph | 1991 |
Nalbuphine and droperidol in combination for sedation and prevention of nausea and vomiting during intra-carotid BCNU infusion.
Topics: Adult; Aged; Brain Neoplasms; Carmustine; Carotid Arteries; Diazepam; Droperidol; Drug Therapy, Comb | 1986 |
The action of diazepam on focal EEG abnormalities.
Topics: Brain; Brain Neoplasms; Cerebrovascular Disorders; Diagnosis, Differential; Diazepam; Electroencepha | 1971 |
Use of diazepam in carotid angiography.
Topics: Anesthesia, Intravenous; Brain; Brain Neoplasms; Carotid Arteries; Cerebral Angiography; Cerebrovasc | 1974 |
Proceedings: Discrimination analysis of the electroencephalogram of healthy volunteers given drugs and of patients with brain tumours.
Topics: Brain; Brain Neoplasms; Diazepam; Electroencephalography; Humans; Methylphenidate | 1974 |
Tinnitus evaluation.
Topics: Bone Conduction; Brain Neoplasms; Cerebellopontine Angle; Craniocerebral Trauma; Diazepam; Ear Neopl | 1973 |
Epileptic pain. An uncommon manifestation with localizing value.
Topics: Adenocarcinoma; Adult; Brain Neoplasms; Cerebral Angiography; Diazepam; Epilepsy; Female; Humans; Ma | 1973 |
[Diagnostic value of the reactivity of E.E.G. foci to diazepam injection. (Statistical study of 327 cases)].
Topics: Adolescent; Adult; Aged; Brain Abscess; Brain Damage, Chronic; Brain Diseases; Brain Edema; Brain In | 1973 |
Myokymia and facial contraction in brain stem glioma. An electromyographic study.
Topics: Action Potentials; Adult; Brain Neoplasms; Carbamazepine; Diazepam; Edrophonium; Electromyography; F | 1974 |
Parenteral diazepam in status epilepticus.
Topics: Adolescent; Adult; Aged; Alcoholism; Brain Neoplasms; Child; Child, Preschool; Diazepam; Electroence | 1969 |
[Cerebrospinal fluid pressure during anesthesia. 2. Effects of intravenous anesthetics].
Topics: Adult; Anesthesia, Intravenous; Anesthetics; Brain Neoplasms; Cerebrospinal Fluid; Cyclohexanes; Dep | 1971 |
[Action of Valium on the EEG slow foci].
Topics: Brain Neoplasms; Cerebrovascular Disorders; Diagnosis, Differential; Diazepam; Electroencephalograph | 1971 |
[Seesaw nystagmus with bitemporal hemianopia following head traumas].
Topics: Adult; Brain Diseases; Brain Neoplasms; Congenital Abnormalities; Craniocerebral Trauma; Craniophary | 1969 |
[Electroencephalographic response to intravenous diazepam in patients with cerebral lesions].
Topics: Brain Diseases; Brain Neoplasms; Carotid Artery Thrombosis; Cerebral Arterial Diseases; Diazepam; El | 1970 |
[Utilization of EEG reactivity to intravenous diazepam for the etiologic diagnosos of cerebral lesions].
Topics: Brain Neoplasms; Cerebral Cortex; Cerebrovascular Disorders; Diagnosis, Differential; Diazepam; Echo | 1968 |