diazepam has been researched along with Brain Injuries in 30 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we describe a lesion that destroys the perforant path in CA3 after status epilepticus (SE) induced by pilocarpine injection in 8-week-old rats." | 3.74 | Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. ( Avoli, M; Baldelli, E; Biagini, G; Contri, MB; Gelosa, P; Guerrini, U; Longo, D; Ragsdale, DS; Sironi, L; Zini, I, 2008) |
| " To determine if immediate post-traumatic events such as seizures may activate Rho, we examined RhoA activation in the brains of rats with kainic acid-induced seizures." | 3.73 | Activation of Rho after traumatic brain injury and seizure in rats. ( Deschamps, K; Dubreuil, CI; Marklund, N; McIntosh, TK; McKerracher, L, 2006) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| "Rats treated with isoflurane had the best cognitive recovery (p < 0." | 1.33 | Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats. ( Alexander, H; Clark, RS; Dixon, CE; Jenkins, L; Kochanek, PM; Statler, KD; Vagni, V, 2006) |
| "Rats treated with diazepam did not differ in mortality from injured rats treated with vehicle." | 1.31 | Positive and negative modulation of the GABA(A) receptor and outcome after traumatic brain injury in rats. ( DeFord, SM; Gibson, CJ; Hamm, RJ; O'Dell, DM; Wilson, MS, 2000) |
| "Diazepam pre-treatment did not restore the expression of amphetamine CPP." | 1.31 | Diazepam modifies the effect of pedunculopontine lesions on morphine but not on amphetamine conditioned place preference. ( Franklin, KB; Leri, F, 2000) |
| "Cerebral edema is responsible for intracranial hypertension and tentorial herniation, which in turn increase edema through venous compression, ischemia, and hypoxia." | 1.27 | [Post-traumatic cerebral edema. Physiopathology and treatment]. ( Jomin, M; Lesoin, F; Lozes, G; Verier, A, 1984) |
| "When diazepam was given 5 min after each convulsion it still had the same effect, although its effects on the ECS-induced changes was blocked by administration of the specific benzodiazepine antagonist Ro 15-1788 (10 mg/kg IP) at the same time as diazepam." | 1.27 | Diazepam administration to mice prevents some of the changes in monoamine-mediated behaviour produced by repeated electroconvulsive shock treatment. ( Green, AR; Mountford, JA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (46.67) | 18.7374 |
| 1990's | 2 (6.67) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 3 (10.00) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mrad, Y | 1 |
| El Jammal, R | 1 |
| Hajjar, H | 1 |
| Alturk, S | 1 |
| Salah, H | 1 |
| Chehade, HD | 1 |
| Dandash, F | 1 |
| Mallah, Z | 1 |
| Kobeissy, F | 1 |
| Habib, A | 1 |
| Hamade, E | 1 |
| Obeid, M | 1 |
| Rojas, A | 1 |
| Wang, J | 1 |
| Glover, A | 1 |
| Dingledine, R | 1 |
| Reddy, DS | 1 |
| Zaayman, M | 1 |
| Kuruba, R | 1 |
| Wu, X | 1 |
| Villasana, LE | 1 |
| Peters, A | 1 |
| McCallum, R | 1 |
| Liu, C | 1 |
| Schnell, E | 1 |
| Biagini, G | 1 |
| Baldelli, E | 1 |
| Longo, D | 1 |
| Contri, MB | 1 |
| Guerrini, U | 1 |
| Sironi, L | 1 |
| Gelosa, P | 1 |
| Zini, I | 1 |
| Ragsdale, DS | 1 |
| Avoli, M | 1 |
| Mtchedlishvili, Z | 1 |
| Lepsveridze, E | 1 |
| Xu, H | 1 |
| Kharlamov, EA | 1 |
| Lu, B | 1 |
| Kelly, KM | 1 |
| Gibson, CJ | 2 |
| Meyer, RC | 1 |
| Hamm, RJ | 2 |
| CANAL, N | 1 |
| Arciniegas, DB | 1 |
| Frey, KL | 1 |
| Anderson, CA | 1 |
| Brousseau, KM | 1 |
| Harris, SN | 1 |
| Nakamura, A | 1 |
| Naito, H | 1 |
| Inoue, M | 1 |
| Masaoka, T | 1 |
| Statler, KD | 1 |
| Alexander, H | 1 |
| Vagni, V | 1 |
| Dixon, CE | 1 |
| Clark, RS | 1 |
| Jenkins, L | 1 |
| Kochanek, PM | 1 |
| Dubreuil, CI | 1 |
| Marklund, N | 1 |
| Deschamps, K | 1 |
| McIntosh, TK | 1 |
| McKerracher, L | 1 |
| Verier, A | 1 |
| Jomin, M | 1 |
| Lozes, G | 1 |
| Lesoin, F | 1 |
| Melnic, L | 1 |
| Caradoc-Davies, TH | 1 |
| O'Dell, DM | 1 |
| Wilson, MS | 1 |
| DeFord, SM | 1 |
| Leri, F | 1 |
| Franklin, KB | 1 |
| Temkin, NR | 1 |
| Escuret, E | 1 |
| Roquefeuil, B | 1 |
| Frerebeau, P | 1 |
| Baldy-Moulinier, M | 1 |
| McDonald, JW | 1 |
| Trescher, WH | 1 |
| Johnston, MV | 1 |
| Iasnetsov, VS | 1 |
| Novikov, VE | 1 |
| Green, AR | 1 |
| Mountford, JA | 1 |
| Schallert, T | 1 |
| Hernandez, TD | 1 |
| Barth, TM | 1 |
| Dahlberg, PJ | 1 |
| Cogbill, TH | 1 |
| Annis, BL | 1 |
| Deering, WM | 1 |
| Ferngren, HG | 1 |
| Ouellette, EM | 1 |
| Soulairac, A | 1 |
| Baron, JB | 1 |
| Langevin, P | 1 |
| Weber, M | 1 |
| Masingue, M | 1 |
| Martin, JY | 1 |
| Tridon, P | 1 |
| Arnould, G | 1 |
| Frowein, RA | 1 |
| Karimi-Nejad, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Amantadine for Neuroenhancement in Acute Patients Study - A Prospective Pilot Proof of Concept Phase IIb Study in Intensive and Intermediate Care Unit Patients[NCT05479032] | Phase 2 | 50 participants (Anticipated) | Interventional | 2022-09-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for diazepam and Brain Injuries
| Article | Year |
|---|---|
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
The child who convulses with fever.
Topics: Age Factors; Analgesics; Brain Injuries; Central Nervous System Diseases; Child; Child Behavior; Chi | 1974 |
28 other studies available for diazepam and Brain Injuries
| Article | Year |
|---|---|
Lestaurtinib (CEP-701) reduces the duration of limbic status epilepticus in periadolescent rats.
Topics: Animals; Brain Injuries; Child; Diazepam; Furans; Hippocampus; Humans; Rats; Status Epilepticus | 2023 |
Urethane attenuates early neuropathology of diisopropylfluorophosphate-induced status epilepticus in rats.
Topics: Acetylcholinesterase; Animals; Brain Injuries; Diazepam; Disease Models, Animal; Electroencephalogra | 2020 |
Comparative profile of refractory status epilepticus models following exposure of cholinergic agents pilocarpine, DFP, and soman.
Topics: Animals; Anticonvulsants; Brain; Brain Injuries; Diazepam; Hippocampus; Isoflurophate; Male; Neurons | 2021 |
Diazepam Inhibits Post-Traumatic Neurogenesis and Blocks Aberrant Dendritic Development.
Topics: Animals; Brain Injuries; Cell Movement; Cell Proliferation; Cell Shape; Dendrites; Diazepam; Disease | 2019 |
Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Brain Injuries; Diazepam; Disease Models, A | 2008 |
Increase of GABAA receptor-mediated tonic inhibition in dentate granule cells after traumatic brain injury.
Topics: Animals; Brain Injuries; Dentate Gyrus; Diazepam; Furosemide; GABA Agonists; GABA Modulators; GABA-A | 2010 |
Traumatic brain injury and the effects of diazepam, diltiazem, and MK-801 on GABA-A receptor subunit expression in rat hippocampus.
Topics: Animals; Blotting, Western; Brain Injuries; Calcium Channel Blockers; Calcium Signaling; Chlorides; | 2010 |
[CLINICAL EXPERIENCES WITH A NEW DRUG OF THE BENZODIAZEPINE SERIES: METHYLDIAZEPINONE].
Topics: Anxiety; Anxiety Disorders; Benzodiazepines; Brain Injuries; Depression; Diazepam; Humans; Mental Di | 1963 |
Amantadine for neurobehavioural deficits following delayed post-hypoxic encephalopathy.
Topics: Adult; Amantadine; Brain; Brain Injuries; Cognition Disorders; Demyelinating Diseases; Diazepam; Dop | 2004 |
Neonatal cerebral cortical lesion abolishes the anxiolytic action of diazepam in adult rats: effects of location and extent of cortical lesion.
Topics: Air; Animals; Animals, Newborn; Anti-Anxiety Agents; Anxiety; Brain Injuries; Diazepam; Electroshock | 2005 |
Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats.
Topics: Anesthetics; Animals; Brain; Brain Injuries; Cell Survival; Cognition Disorders; Diazepam; Disease M | 2006 |
Activation of Rho after traumatic brain injury and seizure in rats.
Topics: Animals; Anticonvulsants; Brain Injuries; Cerebral Cortex; Diazepam; Disease Models, Animal; Drug In | 2006 |
[Post-traumatic cerebral edema. Physiopathology and treatment].
Topics: Alfaxalone Alfadolone Mixture; Barbiturates; Brain Edema; Brain Injuries; Cytidine Diphosphate Choli | 1984 |
[Use of sedatives in seriously ill patients with cerebral neurosurgical disorders].
Topics: Adolescent; Adult; Aged; Brain Diseases; Brain Injuries; Child; Child, Preschool; Diazepam; Female; | 1983 |
Traumatic mutism in severe head injury relieved by oral diazepam.
Topics: Adult; Brain Injuries; Diazepam; Female; Humans; Muscle Relaxants, Central; Mutism | 1996 |
Positive and negative modulation of the GABA(A) receptor and outcome after traumatic brain injury in rats.
Topics: Animals; Bicuculline; Brain Injuries; Cognition; Diazepam; GABA Antagonists; GABA Modulators; Male; | 2000 |
Diazepam modifies the effect of pedunculopontine lesions on morphine but not on amphetamine conditioned place preference.
Topics: Amphetamine; Analysis of Variance; Animals; Anti-Anxiety Agents; Anxiety; Brain Injuries; Central Ne | 2000 |
Effect of hyperventilation associated with administration of central nervous depressants in brain injuries.
Topics: Brain; Brain Injuries; Cerebrovascular Circulation; Diazepam; Humans; Hyperventilation; Phenobarbita | 1977 |
Susceptibility of brain to AMPA induced excitotoxicity transiently peaks during early postnatal development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Aci | 1992 |
[The GABA-ergic system and brain edema].
Topics: Animals; Anti-Anxiety Agents; Benactyzine; Benzodiazepines; Benzodiazepinones; Brain Edema; Brain In | 1985 |
Diazepam administration to mice prevents some of the changes in monoamine-mediated behaviour produced by repeated electroconvulsive shock treatment.
Topics: Animals; Brain; Brain Injuries; Diazepam; Electric Injuries; Mice; Mice, Inbred C57BL; Receptors, Ad | 1985 |
Recovery of function after brain damage: severe and chronic disruption by diazepam.
Topics: Animals; Brain Injuries; Diazepam; Functional Laterality; Male; Nerve Crush; Nerve Regeneration; Neu | 1986 |
Malignant posttraumatic hypermetabolic syndrome associated with brain injury.
Topics: Adolescent; Adult; Brain Injuries; Diazepam; Female; Humans; Male; Metabolic Diseases; Muscle Contra | 1985 |
Diazepam treatment for acute convulsions in children. A report of 41 patients, three with plasma levels.
Topics: Adolescent; Age Factors; Brain Damage, Chronic; Brain Injuries; Child; Child, Preschool; Diazepam; E | 1974 |
[Statokinesimetric study of postural regulation in man (normal and pathologic variations)].
Topics: Brain Injuries; Diazepam; Humans; Posture; Succinates | 1967 |
[Convulsions in children].
Topics: Adolescent; Adult; Anticonvulsants; Birth Injuries; Brain Diseases; Brain Injuries; Child; Child, Pr | 1973 |
[Diagnostic value of the reactivity of E.E.G. foci to diazepam injection. (Statistical study of 327 cases)].
Topics: Adolescent; Adult; Aged; Brain Abscess; Brain Damage, Chronic; Brain Diseases; Brain Edema; Brain In | 1973 |
[Intensive therapy in craniocerebral injuries].
Topics: Adolescent; Adult; Aged; Brain Injuries; Child; Child, Preschool; Craniocerebral Trauma; Diazepam; H | 1969 |