Page last updated: 2024-10-25

diazepam and Aura

diazepam has been researched along with Aura in 530 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Research Excerpts

ExcerptRelevanceReference
"Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration."9.41Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. ( Biton, V; Carrazana, E; Cascino, GD; Cook, DF; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021)
" Diazepam nasal spray (Valtoco®) is a proprietary intranasal formulation approved for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) in patients with epilepsy aged ≥6 years."9.41Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study. ( Carrazana, E; Cascino, GD; Davis, C; Desai, J; Hogan, RE; Liow, K; Rabinowicz, AL; Sperling, MR; Tarquinio, D; Wheless, JW, 2021)
"A Phase 3 open-label safety study (NCT02721069) evaluated long-term safety of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters."9.41Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. ( Biton, V; Carrazana, E; Cascino, GD; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Mauney, W; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021)
"To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states."9.34Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study. ( Carrazana, E; Hogan, RE; Klein, P; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D, 2020)
"In this phase III, randomized, double‐blind, parallel‐group, placebo‐controlled, multicenter study, subjects with epilepsy on a stable antiepileptic drug regimen who required intermittent medical intervention to control ARS were randomized 1:1 to the placebo AI or the diazepam AI group."9.17A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures. ( Abou-Khalil, B; Goli, V; Pixton, GC; Rogin, J; Roland, CL; Sherman, NA; Shukla, RB; Sommerville, K; Wheless, J; Wolter, KD, 2013)
"To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy."9.14Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy. ( Adelgais, K; Dudley, N; Filloux, F; Firth, S; Greenberg, R; Healy, A; Holsti, M; Olsen, C; Schunk, J, 2010)
"The purpose of these investigations was to determine from combined data the response to rectal diazepam (DZP) gel (Diastat [Athena Neurosciences, South San Francisco, CA]) in home treatment of children with episodes of acute repetitive seizures (ARS)."9.09Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group. ( Cereghino, JJ; Cloyd, JC; Kriel, RL; Mitchell, WG; Pellock, JM; Rosman, NP, 1999)
"Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial."9.08Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995)
"Lamotrigine, a novel anticonvulsant, has been evaluated in patients with epilepsy using the method of interictal EEG spike counting."9.06The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy. ( Jawad, S; Oxley, J; Richens, A; Yuen, WC, 1986)
"To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats."8.31Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023)
" We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus."8.31Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023)
"We gained insights into NfL levels during the various phases of the intrahippocampal kainic acid mouse model of temporal lobe epilepsy-namely, the status epilepticus (SE) and the chronic phase with spontaneous seizures."8.31Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy? ( Barbé, K; Bjerke, M; Custers, ML; Kaltenböck, L; Smolders, I; Van Eeckhaut, A; Vande Vyver, M, 2023)
"Patients prescribed sublingual lorazepam solution at the Johns Hopkins Epilepsy Center for acute seizure treatment during a 5-year period (2012-2017) were screened."8.31Sublingual lorazepam as rescue therapy for seizure emergencies in adults. ( Krauss, GL; Lelis, IR, 2023)
" In vivo, C57BL/6 mice that received intrahippocampal WNK463 experienced delayed onset of kainic acid-induced status epilepticus, less epileptiform EEG activity, and did not develop pharmaco-resistance to diazepam."8.12Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus. ( Abiraman, K; Brandon, NJ; Deeb, TZ; Lee, KL; Lucaj, C; Maguire, J; Moss, SJ; Ollerhead, TA, 2022)
" The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ."7.83Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016)
"Rectal diazepam solution, administered by capable caregivers, is as effective and safe as rectal administration of IVD for children with intractable epilepsy."7.77Rectal diazepam solution is as good as rectal administration of intravenous diazepam in the first-aid cessation of seizures in children with intractable epilepsy. ( Chen, YI; Chiang, LM; Chou, ML; Deng, ST; Hung, PC; Lin, KL; Shen, HH; Tseng, CH; Wang, HS, 2011)
" The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats."7.75Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009)
"To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model."7.73Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006)
"The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs."7.70Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998)
"The rectal administration of diazepam (DZP) has provided a safer existence to many epilepsy patients and their carers, when prolonged or serial seizures are present."7.70Rectal diazepam: pitfalls of excessive use in refractory epilepsy. ( Aamo, T; Brodtkorb, E; Henriksen, O; Lossius, R, 1999)
"Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors."7.70Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000)
"We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy."7.69BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997)
"Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline."7.68Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993)
"Diazepam-induced EEG changes were analyzed both visually and by computer in epilepsy for localization of epileptogenic lesion."7.68[Visual and computer evaluation of diazepam-induced EEG changes in epilepsy for localization of epileptogenic lesion]. ( Huang, Z, 1992)
"Rapid diazepam (DZP) introduction was investigated in 24 children with different types of cryptogenic or symptomatic generalized epilepsy and EEG epileptic "status" with EEG and pharmacologic monitoring."7.68Rapid diazepam introduction (venous or rectal) in childhood epilepsy: taxonomic and therapeutic considerations. ( Baglietto, MG; De Negri, M; Gaggero, R; Pallecchi, A; Pessagno, A; Veneselli, E, 1991)
"The mechanisms underlying tolerance to benzodiazepines were investigated by injecting diazepam (5 mg/kg) twice daily for 23 days in WAG/Rij rats (an animal model for non-convulsive absence epilepsy)."7.68Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam. ( Coenen, AM; Nutt, DJ; Peeters, BW; Titulaer, MN; Van Rijn, CM; Vossen, JM, 1990)
"Thirty cases of intractable epilepsy in children were investigated to observe the correlation between the suppression of seizure discharges to intravenous diazepam and the type of seizure or effects of subsequent therapy."7.66Diagnostic and prognostic significance of electroencephalography with intravenous diazepam in epilepsy. ( Goya, N; Kurokawa, T; Mitsudome, A; Shibata, R; Takashima, S; Yokota, K, 1979)
" Safety assessments included treatment-emergent adverse events (TEAEs)."7.11Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study. ( Carrazana, E; Desai, J; Dlugos, D; Rabinowicz, AL; Tarquinio, D; Wheless, JW, 2022)
" Adverse events (AEs) and usability assessments were recorded after the first dose, then every 3 months."6.94Safety and tolerability associated with chronic intermittent use of diazepam buccal film in adult, adolescent, and pediatric patients with epilepsy. ( Buan, C; Gelfand, MA; Heller, AH; Seinfeld, S; Slatko, G, 2020)
"Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population."6.82Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016)
"No patient in the VPA group developed respiratory depression, hypotension, or hepatic dysfunction, whereas in the DZP group, 5."6.76Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. ( Chen, WB; Fan, CQ; Gao, R; Ren, Y; Su, YY; Wang, L; Zhang, YZ; Zhao, JW, 2011)
" Currently, Diazepam rectal gel is the only approved therapy for the outpatient management of seizures, but there is a growing need for alternative medications for terminating seizures that may be not only safe and effective but also socially acceptable."6.52Safety and efficacy of diazepam autoinjector for the management of epilepsy. ( Milioni, M; Verrotti, A; Zaccara, G, 2015)
"Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy."5.43Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016)
" Diazepam rectal gel, intranasal midazolam, and diazepam nasal spray are US Food and Drug Administration (FDA)-approved seizure-cluster rescue medications, and intravenous diazepam and lorazepam are approved for status epilepticus."5.41Acute Abortive Therapies for Seizure Clusters in Long-Term Care. ( Becker, DA; Birnbaum, AK; Carrazana, E; Misra, SN; Rabinowicz, AL; Ramsay, RE; Vazquez, B, 2023)
"Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration."5.41Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. ( Biton, V; Carrazana, E; Cascino, GD; Cook, DF; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021)
" Diazepam nasal spray (Valtoco®) is a proprietary intranasal formulation approved for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) in patients with epilepsy aged ≥6 years."5.41Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study. ( Carrazana, E; Cascino, GD; Davis, C; Desai, J; Hogan, RE; Liow, K; Rabinowicz, AL; Sperling, MR; Tarquinio, D; Wheless, JW, 2021)
" Diazepam nasal spray is approved to treat seizure clusters in patients with epilepsy ≥6 years of age."5.41Consistent safety and tolerability of Valtoco ( Biton, V; Carrazana, E; Cascino, GD; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Mauney, W; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021)
"A Phase 3 open-label safety study (NCT02721069) evaluated long-term safety of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters."5.41Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. ( Biton, V; Carrazana, E; Cascino, GD; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Mauney, W; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021)
"Further, in both cases, auditory agnosia was associated with sleep-activated electroencephalographic (EEG) epileptiform activity, consistent with Landau-Kleffner syndrome."5.40Episodic epileptic verbal auditory agnosia in Landau Kleffner syndrome treated with combination diazepam and corticosteroids. ( Bojko, A; Devinsky, O; Goldberg, R; Miles, D; Riviello, J, 2014)
"Lacosamide (Vimpat) is a newly licensed novel antiepileptic drug."5.36Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. ( Eggers, C; Hofer, T; Resch, R; Tilz, C, 2010)
"To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states."5.34Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study. ( Carrazana, E; Hogan, RE; Klein, P; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D, 2020)
"In PTZ-induced epileptic seizures, the i."5.33Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005)
"In this phase III, randomized, double‐blind, parallel‐group, placebo‐controlled, multicenter study, subjects with epilepsy on a stable antiepileptic drug regimen who required intermittent medical intervention to control ARS were randomized 1:1 to the placebo AI or the diazepam AI group."5.17A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures. ( Abou-Khalil, B; Goli, V; Pixton, GC; Rogin, J; Roland, CL; Sherman, NA; Shukla, RB; Sommerville, K; Wheless, J; Wolter, KD, 2013)
"To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy."5.14Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy. ( Adelgais, K; Dudley, N; Filloux, F; Firth, S; Greenberg, R; Healy, A; Holsti, M; Olsen, C; Schunk, J, 2010)
"The purpose of these investigations was to determine from combined data the response to rectal diazepam (DZP) gel (Diastat [Athena Neurosciences, South San Francisco, CA]) in home treatment of children with episodes of acute repetitive seizures (ARS)."5.09Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group. ( Cereghino, JJ; Cloyd, JC; Kriel, RL; Mitchell, WG; Pellock, JM; Rosman, NP, 1999)
"To assess safety of diazepam rectal gel (DZPRG) for control of acute seizures in epilepsy patients and to evaluate tolerance with repeated use of DZPRG at intervals of > or =5 days."5.09An open-label study of repeated use of diazepam rectal gel (Diastat) for episodes of acute breakthrough seizures and clusters: safety, efficacy, and tolerance. North American Diastat Group. ( Cereghino, JJ; Conry, JA; Crumrine, PK; Groves, L; Kriel, RL; Mitchell, WG; Rosenfeld, WE, 1999)
"Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial."5.08Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995)
"Lamotrigine, a novel anticonvulsant, has been evaluated in patients with epilepsy using the method of interictal EEG spike counting."5.06The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy. ( Jawad, S; Oxley, J; Richens, A; Yuen, WC, 1986)
"Rectal administration of several different preparations of diazepam to a group of adult volunteer patients with epilepsy produced variable rates of absorption."5.05Absorption of diazepam from the rectum and its effect on interictal spikes in the EEG. ( Dhillon, S; Milligan, N; Oxley, J; Richens, A, 1982)
"Diazepam rectal gel (Diastat) is the only medication approved by the US FDA for the management of selected, refractory patients with epilepsy, on stable regimens of antiepilepsy drugs, who require intermittent use of diazepam to control bouts of increased seizure activity."4.82Safety of Diastat, a rectal gel formulation of diazepam for acute seizure treatment. ( Pellock, JM, 2004)
" Intermittent diazepam prophylaxis at times of fever may or may not reduce the recurrence rate significantly, but there is no data to suggest that it improves the long-term outcome, as compared with short-term seizure control, in terms of IQ, cognition, academic progress, motor control, and subsequent epilepsy."4.81[Febrile convulsions, Treatment and prognosis]. ( Knudsen, FU, 2001)
" Clonazepam, chlorazepate, nitrazepam and clobazam are also prescribed as chronic treatment of various forms of epilepsy."4.76[Benzodiazepines in the treatment of epilepsy]. ( Loiseau, P, 1983)
"To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats."4.31Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023)
" We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus."4.31Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023)
"We gained insights into NfL levels during the various phases of the intrahippocampal kainic acid mouse model of temporal lobe epilepsy-namely, the status epilepticus (SE) and the chronic phase with spontaneous seizures."4.31Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy? ( Barbé, K; Bjerke, M; Custers, ML; Kaltenböck, L; Smolders, I; Van Eeckhaut, A; Vande Vyver, M, 2023)
"Patients prescribed sublingual lorazepam solution at the Johns Hopkins Epilepsy Center for acute seizure treatment during a 5-year period (2012-2017) were screened."4.31Sublingual lorazepam as rescue therapy for seizure emergencies in adults. ( Krauss, GL; Lelis, IR, 2023)
" In vivo, C57BL/6 mice that received intrahippocampal WNK463 experienced delayed onset of kainic acid-induced status epilepticus, less epileptiform EEG activity, and did not develop pharmaco-resistance to diazepam."4.12Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus. ( Abiraman, K; Brandon, NJ; Deeb, TZ; Lee, KL; Lucaj, C; Maguire, J; Moss, SJ; Ollerhead, TA, 2022)
"The aim of this study was to review out-of-hospital use of intranasal diazepam and midazolam for treatment of acute repetitive seizures (ARS) at a typical adult epilepsy center."4.12Use of new intranasal benzodiazepines at a typical adult epilepsy center. ( Benbadis, SR; Li, C, 2022)
" The present study was designed to investigate the effect of acute and chronic administration of thiamine alone and in combination with sub-effective dose of diazepam on pentylenetetrazole (PTZ)-induced tonic-clonic seizures in mice."3.91Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice. ( Abed, A; Alinejad, M; Banafshe, HR; Heydari, A; Mesdaghinia, A, 2019)
" The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ."3.83Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016)
" This new method documented that seizures in the zebrafish EAST model were ameliorated by pentobarbitone, but not diazepam, validating its usefulness."3.79Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings. ( Bockenhauer, D; Kleta, R; Mahmood, F; Russell, C; Stanescu, HC; Zdebik, AA, 2013)
" Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P < 0."3.79Hypoxia markers are expressed in interneurons exposed to recurrent seizures. ( Biagini, G; Gualtieri, F; Longo, D; Marinelli, C; Meletti, S; Nichelli, PF; Pugnaghi, M, 2013)
"Catamenial epilepsy is caused by fluctuations in progesterone-derived GABA(A) receptor-modulating anticonvulsant neurosteroids, such as allopregnanolone, that play a significant role in the pathophysiology of epilepsy."3.78A mouse kindling model of perimenstrual catamenial epilepsy. ( Gangisetty, O; Gould, J; Reddy, DS, 2012)
"  The endocannabinoid system is known to modulate seizure activity in several in vivo and in vitro models, and CB(1) -receptor activation is anticonvulsant in the rat pilocarpine model of acquired epilepsy (AE)."3.78Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain. ( Blair, RE; DeLorenzo, RJ; Nguyen, PT; Sayers, KW; Sim-Selley, LJ, 2012)
"Rectal diazepam solution, administered by capable caregivers, is as effective and safe as rectal administration of IVD for children with intractable epilepsy."3.77Rectal diazepam solution is as good as rectal administration of intravenous diazepam in the first-aid cessation of seizures in children with intractable epilepsy. ( Chen, YI; Chiang, LM; Chou, ML; Deng, ST; Hung, PC; Lin, KL; Shen, HH; Tseng, CH; Wang, HS, 2011)
"Acute application of human ASCs-E before SE led to earlier attenuation of seizure spike activities after treatment with diazepam, reduction of BBB leakage, and inhibition of the development of epilepsy."3.77A cell-free extract from human adipose stem cells protects mice against epilepsy. ( Ban, JJ; Chu, K; Jeon, D; Jung, KH; Kang, KM; Kim, M; Kim, S; Lee, SK; Lee, ST; Roh, JK; Seo, JS; Won, CH, 2011)
"Rectal diazepam is established as a standard rescue or emergency treatment for seizure or status epilepticus; however, the rectal route of administration has not been universally accepted."3.76A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations. ( Bertram, E; de Haan, GJ; Doelman, G; Edelbroek, P; van der Geest, P, 2010)
"The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test."3.76Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010)
" The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats."3.75Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009)
"This study was conducted to identify how often parents of children with epilepsy encounter barriers to the use of diazepam rectal gel in day care or school settings and how these barriers affect the child and family."3.74Acceptance of the use of diazepam rectal gel in school and day care settings. ( Karn, M; Paolicchi, J; Terry, D, 2007)
"During her first pregnancy, a 37-year-old woman with idiopathic generalised epilepsy that was adequately controlled with lamotrigine experienced a series of epileptic seizures following an elective caesarean section."3.73[Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy]. ( Bloem, BR; Renier, WO; Voermans, NC; Zwarts, MJ, 2005)
"To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model."3.73Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006)
" Although epilepsy-like symptoms occurred at the first course of VIP therapy, these symptoms immediately improved by diazepam administration."3.72[A case of advanced rhabdomyosarcoma of the spermatic cord who occurred epilepsy-like symptoms, but was completely responded to chemotherapy]. ( Kobayashi, M; Suzuki, K; Tokue, A, 2004)
"Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone-derived neurosteroid allopregnanolone that potentiates gamma-aminobutyric acidA (GABA(A)) receptor-mediated inhibition."3.71Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2001)
"A pilot study involved two primary school children with unstable epilepsy, whose medical treatment included intermittent rectal Diazepam."3.70Who cares for students with epilepsy in mainstream education? ( Lanfear, JH; Rashid, C, 1998)
"The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs."3.70Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998)
"The rectal administration of diazepam (DZP) has provided a safer existence to many epilepsy patients and their carers, when prolonged or serial seizures are present."3.70Rectal diazepam: pitfalls of excessive use in refractory epilepsy. ( Aamo, T; Brodtkorb, E; Henriksen, O; Lossius, R, 1999)
"Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors."3.70Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000)
"The development of tolerance to the anticonvulsant effects of clonazepam, clobazam, and diazepam were studied in genetically epilepsy-prone rats following intraperitoneal (IP) or oral administration."3.69Tolerance to anticonvulsant effects of some benzodiazepines in genetically epilepsy prone rats. ( Aguglia, U; de Sarro, A; De Sarro, G; Di Paola, ED, 1996)
"Following pilocarpine-induced status epilepticus, rats become chronically epileptic showing 2-3 spontaneous recurrent seizures per week."3.69Blockade of spreading depression in chronic epileptic rats: reversion by diazepam. ( Cavalheiro, EA; Guedes, RC, 1997)
"We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy."3.69BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997)
"Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline."3.68Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993)
"Diazepam-induced EEG changes were analyzed both visually and by computer in epilepsy for localization of epileptogenic lesion."3.68[Visual and computer evaluation of diazepam-induced EEG changes in epilepsy for localization of epileptogenic lesion]. ( Huang, Z, 1992)
"Rapid diazepam (DZP) introduction was investigated in 24 children with different types of cryptogenic or symptomatic generalized epilepsy and EEG epileptic "status" with EEG and pharmacologic monitoring."3.68Rapid diazepam introduction (venous or rectal) in childhood epilepsy: taxonomic and therapeutic considerations. ( Baglietto, MG; De Negri, M; Gaggero, R; Pallecchi, A; Pessagno, A; Veneselli, E, 1991)
"The mechanisms underlying tolerance to benzodiazepines were investigated by injecting diazepam (5 mg/kg) twice daily for 23 days in WAG/Rij rats (an animal model for non-convulsive absence epilepsy)."3.68Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam. ( Coenen, AM; Nutt, DJ; Peeters, BW; Titulaer, MN; Van Rijn, CM; Vossen, JM, 1990)
"We have investigated the influence of central noradrenergic and dopaminergic systems on the susceptibility of rats to seizures in the kainic acid (KA)-model of epilepsy."3.67Kainic acid-induced seizures: potentiation by alpha-methyl-p-tyrosine. ( Baran, H; Hornykiewicz, O; Hörtnagl, H, 1989)
"Three drugs which increase GABA-mediated inhibitory neurotransmission in the brain, namely the GABA degradation inhibitors aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG), and the GABA receptor agonist THIP (gaboxadol), were administered to epilepsy-prone gerbils via subcutaneously implanted osmotic minipumps for 2 weeks."3.67Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. ( Löscher, W, 1986)
"We evaluated the EEG reaction to an intravenous injection of diazepam as an additional tool in difficult localization problems in epilepsy."3.66Correlations between EEG changes induced by diazepam and the localization of epileptic spikes and seizures. ( Gloor, P; Gotman, J; Olivier, A; Quesney, LF, 1982)
"Repeated seizures, whether induced by kindling or electroshock, caused a long-lasting (at least 24 hr) increase of [3H]diazepam binding in hippocampal membranes of Sprague-Dawley rats."3.66Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors. ( McNamara, JO; Patrone, V; Peper, AM, 1980)
"The absorption of diazepam after rectal administration was studied in children with epilepsy."3.66Rectal absorption of diazepam in epileptic children. ( Dhillon, S; Ngwane, E; Richens, A, 1982)
"Thirty cases of intractable epilepsy in children were investigated to observe the correlation between the suppression of seizure discharges to intravenous diazepam and the type of seizure or effects of subsequent therapy."3.66Diagnostic and prognostic significance of electroencephalography with intravenous diazepam in epilepsy. ( Goya, N; Kurokawa, T; Mitsudome, A; Shibata, R; Takashima, S; Yokota, K, 1979)
" The treatment of status epilepticus with intravenous phenytoin is effective."3.66Epilepsy and pregnancy. ( Bruni, J; Willmore, LJ, 1979)
"In a prospective study 44 children, aged 6 months to 5 years, admitted to hospital with febrile convulsions or epilepsy, were treated with diazepam in solution administered rectally during 59 generalised attacks."3.66Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children. ( Knudsen, FU, 1979)
"The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed."3.65[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977)
" In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida."3.65A teratological evaluation of anticonvulsant drugs. ( Czeizel, E; Lakos, P, 1977)
" Concomitant CBD use was recorded, and treatment-emergent adverse events (TEAEs) were collected."3.30Concomitant cannabidiol does not impact safety and effectiveness of diazepam nasal spray for seizure clusters: Post hoc analysis of a phase 3 safety study. ( Carrazana, E; Misra, SN; Peters, JM; Puri, V; Rabinowicz, AL; Segal, E, 2023)
" Across groups, treatment-emergent adverse event rates ranged from 66."3.30Safety of Diazepam Nasal Spray in Pediatric Patients With Developmental Epileptic Encephalopathies: Results From a Long-term Phase 3 Safety Study. ( Carrazana, E; Misra, SN; Rabinowicz, AL; Segal, EB; Tarquinio, D; Wheless, JW, 2023)
" Safety assessments included treatment-emergent adverse events (TEAEs)."3.11Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study. ( Carrazana, E; Desai, J; Dlugos, D; Rabinowicz, AL; Tarquinio, D; Wheless, JW, 2022)
"Epilepsy is a chronic disease of the central nervous system characterized by recurrent epileptic seizures."3.01Second Generation of Antiepileptic Drugs and Oxidative Stress. ( Czuczwar, SJ; Kamieniak, M; Kośmider, K; Miziak, B, 2023)
"Patients with epilepsy can experience seizure clusters (acute repetitive seizures), defined as intermittent, stereotypic episodes of frequent seizure activity that are distinct from typical seizure patterns."3.01Overcoming barriers to the management of seizure clusters: ease of use and time to administration of rescue medications. ( Bougher, G; Dean, P; Desai, J; Dewar, S; Misra, SN; O'Hara, K, 2023)
" Adverse events (AEs) and usability assessments were recorded after the first dose, then every 3 months."2.94Safety and tolerability associated with chronic intermittent use of diazepam buccal film in adult, adolescent, and pediatric patients with epilepsy. ( Buan, C; Gelfand, MA; Heller, AH; Seinfeld, S; Slatko, G, 2020)
"Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population."2.82Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016)
"No patient in the VPA group developed respiratory depression, hypotension, or hepatic dysfunction, whereas in the DZP group, 5."2.76Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. ( Chen, WB; Fan, CQ; Gao, R; Ren, Y; Su, YY; Wang, L; Zhang, YZ; Zhao, JW, 2011)
"Diazepam treatment was superior to placebo with regard to the outcome variables related to efficacy: reduced seizure frequency (P<0."2.69A comparison of rectal diazepam gel and placebo for acute repetitive seizures. ( Bell, WE; Bergen, DC; Cloyd, JC; Conry, JA; Dreifuss, FE; Kuzniecky, RI; Lo, WD; Matsuo, F; Pellock, JM; Rosman, NP; Sharp, GB, 1998)
"A cohort of 289 children with febrile convulsions who had been randomised in early childhood to either intermittent prophylaxis (diazepam at fever) or no prophylaxis (diazepam at seizures) was followed up 12 years later."2.68Long term outcome of prophylaxis for febrile convulsions. ( Andersen, R; Andresen, J; Knudsen, FU; Paerregaard, A, 1996)
"When flumazenil (3 mg) was administered immediately after intravenous diazepam (10 mg), the reduction in interictal epileptic activity was not significantly different from that produced by diazepam alone."2.67The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study. ( Hart, YM; Meinardi, H; Nutt, DJ; Sander, JW; Shorvon, SD, 1991)
"Diazepam was administered rectally as a new experimental suppository formulation immediately after a seizure and was highly effective in preventing recurrent fits within a 24 h observation period (p less than 0."2.65A clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients. ( Dhillon, S; Griffiths, A; Milligan, NM; Oxley, J; Richens, A, 1984)
" Currently, Diazepam rectal gel is the only approved therapy for the outpatient management of seizures, but there is a growing need for alternative medications for terminating seizures that may be not only safe and effective but also socially acceptable."2.52Safety and efficacy of diazepam autoinjector for the management of epilepsy. ( Milioni, M; Verrotti, A; Zaccara, G, 2015)
"Febrile seizures are most common seizures in childhood (2-4%)."2.42[Febrile seizures--an update]. ( Püst, B, 2004)
"However, there is no evidence that treatment of simple febrile seizures can prevent the rare cases of later epilepsy, and many children with complex febrile seizures have a benign long-term outcome, even without treatment."2.41Febrile seizures: treatment and prognosis. ( Knudsen, FU, 2000)
"Epilepsy affects 1."2.41New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000)
"Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism."2.41Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001)
"Fosphenytoin has recently been approved as a substitute for parenteral phenytoin."2.40New drug therapy for acute seizure management. ( Morton, LD; Pellock, JM; Rizkallah, E, 1997)
"Successful treatment of seizure disorders in small animals requires proper patient assessment, understanding the principles of antiepileptic drug (AED) therapy, designing a strategy for pharmacotherapy, and plans for emergency treatment."2.40Antiepileptic drug therapy. ( Podell, M, 1998)
"Sequelae and risk for recurrence of SE are primarily related to the underlying cause."2.39Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996)
" However, their chronic use may be associated with serious sedative-hypnotic effects that interfere with cognitive function and behavior."2.37Use of barbiturates and benzodiazepines in treatment of epilepsy. ( Vining, EP, 1986)
"Epilepsy is a common neurological disorder which affects 50 million people worldwide."1.72Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio). ( Aguiar, GPS; Lima-Rezende, CA; Müller, LG; Oliveira, JV; Pedroso, J; Piato, A; Schneider, SE; Siebel, AM, 2022)
"Beyond effectiveness for aborting seizure clusters, no data exist on how intermittent rescue therapy may impact the long-term natural course of seizure clusters."1.72Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters. ( Carrazana, E; Davis, C; Misra, SN; Peters, JM; Rabinowicz, AL; Rao, VR; Sperling, MR, 2022)
" Using an animal model of chemically-induced epileptic seizures, we tested exercise alone as non-pharmacological therapy, and exercise combined with an anti-inflammatory drug."1.72Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures. ( Barbosa, BB; Coitinho, AS; de Lima Rosa, G; Domingues, AM; Guzzo, EFM; Nunes, SEB; Padilha, RB; Siqueira, IR, 2022)
"camptopus in acute models of epileptic seizures in Wistar rats."1.62Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats. ( Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD, 2021)
"Status epilepticus is defined as a state of unrelenting seizure activity."1.51Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus. ( Akerman, CJ; Burman, RJ; Calin, A; Codadu, NK; Katz, AA; Lee, JH; Newey, SE; Parrish, RR; Raimondo, JV; Selfe, JS; Trevelyan, AJ; van den Berg, M; Wilmshurst, JM; Wright, R, 2019)
", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule."1.43Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016)
"Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy."1.43Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016)
"To determine the prognostic factors for encephalopathy with bright tree appearance (BTA) in the acute phase through retrospective case evaluation."1.42Prognostic factors for acute encephalopathy with bright tree appearance. ( Azuma, J; Iwatani, Y; Kagitani-Shimono, K; Kitai, Y; Nabatame, S; Nagai, T; Nakano, S; Okinaga, T; Ozono, K; Tominaga, K; Yamamoto, T, 2015)
"We report one Chinese patient with neurosyphilis exhibiting periodic lateralized epileptiform discharges (PLEDs) in the electroencephalogram (EEG)."1.40A patient with progressive cognitive decline and periodic abnormal waves in EEG: PLEDs of neurosyphilis or PSDs of Creutzfeldt-Jakob disease? ( Chu, F; Cui, L; Lv, Y; Meng, H; Wang, Z, 2014)
"Further, in both cases, auditory agnosia was associated with sleep-activated electroencephalographic (EEG) epileptiform activity, consistent with Landau-Kleffner syndrome."1.40Episodic epileptic verbal auditory agnosia in Landau Kleffner syndrome treated with combination diazepam and corticosteroids. ( Bojko, A; Devinsky, O; Goldberg, R; Miles, D; Riviello, J, 2014)
"A device capable of detecting seizures and alerting caregivers would be a major advance for epilepsy management, and could be used to guide early intervention and prevent seizure-related injuries."1.39Feasibility study of a caregiver seizure alert system in canine epilepsy. ( Cloyd, JC; Coles, LD; Higgins, J; Leyde, K; Litt, B; Mavoori, J; Michael, B; Patterson, EE; Sheffield, WD; Vite, C; Worrell, GA, 2013)
"Pretreatment with diazepam (DZP) significantly attenuated seizure severity."1.39Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization. ( Baggio, S; Battastini, AM; Calcagnotto, ME; Campos, MM; de Oliveira, DL; Dias, RD; Leite, CE; Moro, L; Mussulini, BH; Rico, EP; Rosemberg, DB; Souza, TM; Zenki, KC, 2013)
"Valproic acid was less effective in OHSCs than in the kindled seizure tests, and diazepam was more (generalized seizures) or less (focal seizures and afterdischarge durations) effective in this animal model than in OHSCs."1.38Primary afterdischarge in organotypic hippocampal slice cultures: effects of standard antiepileptic drugs. ( Albus, K; Heinemann, U; Wahab, A, 2012)
"The EEGs performed during migraine-free period, on the contrary, showed very rare and mild subclinical ictal discharges."1.37Migraine triggered by epileptic discharges in a Rasmussen's encephalitis patient after surgery. ( Ciofetta, G; Fusco, L; Longo, D; Specchio, N; Trivisano, M; Vigevano, F, 2011)
"Epilepsy affects 0."1.37Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. ( Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G, 2011)
"Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear."1.37Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. ( Hu, XL; Liu, YY; Mei, L; Tan, GH; Xiong, ZQ; Yin, DM, 2011)
"Lacosamide (Vimpat) is a newly licensed novel antiepileptic drug."1.36Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. ( Eggers, C; Hofer, T; Resch, R; Tilz, C, 2010)
"PPhenytoin was 10-fold less (1."1.34Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs. ( Cucullo, L; Hossain, M; Janigro, D; Manders, T; Marchi, N; Rapp, E, 2007)
"Upon treatment with diazepam and haloperidol, the psychosis subsided within three days."1.34[Postictal paranoid-hallucinatory psychosis in cryptogenic epilepsy]. ( Baum, P; Hermann, W; Kopf, A; Wagner, A, 2007)
"In PTZ-induced epileptic seizures, the i."1.33Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005)
"The authors reviewed respiratory adverse events and deaths spontaneously reported to Xcel Pharmaceuticals associated with diazepam rectal gel."1.33Respiratory adverse events associated with diazepam rectal gel. ( Pellock, JM; Shinnar, S, 2005)
"Reported are three patients with ictal monoparesis of an arm."1.33Ictal monoparesis associated with lesions in the primary somatosensory area. ( Aoki, T; Hanakawa, T; Hitomi, T; Ikeda, A; Matsumoto, R; Miki, Y; Shibasaki, H; Shimohama, S; Tomimoto, H, 2005)
"Phenytoin is a known inducer of drugs metabolized by CYP2C, CYP2D, and CYP3A, but its own metabolism may be altered by drugs influencing CYP2C9 or CYP2C19, such as diazepam."1.32Phenytoin-diazepam interaction. ( Murphy, A; Wilbur, K, 2003)
" Marked differences in drug sensitivity were observed between models based on single and chronic administration of PTZ showing that the two sets of models are fundamentally different."1.32Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice. ( Hansen, SL; Sánchez, C; Sperling, BB, 2004)
"A partial but significant inhibition of convulsions was found in these animals."1.31Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam. ( Jayakumar, AR; Vanaja, P, 2001)
"Diazepam (DZP) was intraperitoneally injected (0."1.30Diazepam--its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss. ( Becker, A; Grecksch, GA; Tiedge, A, 1997)
"Patients with epileptic and nonepileptic seizures are commonly encountered in clinical practice, and they can pose a difficult diagnostic problem."1.30Cerebral perfusion SPECT imaging in epileptic and nonepileptic seizures. ( Blend, MJ; de León, OA; Gaviria, M; Jobe, TH; Lin, Q; Sychra, JJ, 1997)
"Two pharmacoeconomic studies on the treatment of acute seizures have been conducted."1.30Pharmacoeconomic considerations in treatment options for acute seizures. ( Graves, N, 1998)
" Similarly, there was a reduction in maximal plasma concentration, bioavailability (F), mean residence time, and time to target and peak concentrations in the postphenobarbital p."1.30Chronic phenobarbital therapy reduces plasma benzodiazepine concentrations after intravenous and rectal administration of diazepam in the dog. ( Podell, M; Sams, RA; Wagner, SO, 1998)
"Simple febrile seizures that occur in children ages 6 months to 5 years are common events with few adverse outcomes."1.30Technical report: treatment of the child with simple febrile seizures. ( Baumann, RJ, 1999)
"Seizures are a frequent problem confronting EMS personnel."1.30Prehospital management of the seizure patient. ( Nicholl, JS, 1999)
"In diazepam chronically treated mice, it attenuated diazepam tolerance (provoked by later acute administration of diazepam together with convulsant) and postponed physical dependence/withdrawal effects (provoked by later administration of isoniazid)."1.30The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam. ( Anic, T; Aralica, G; Dodig, G; Duplancie, B; Jelovac, N; Marovic, A; Mise, S; Perovic, D; Petek, M; Pigac, B; Prkacin, I; Rucman, R; Sebecic, B; Seiwerth, S; Sikiric, P; Slobodnjak, Z; Stancic-Rokotov, D; Turkovic, B; Ziger, T; Zoricic, I, 1999)
"We present the case of a patient that after chronic use of anticonvulsant drugs without proven epilepsy, developed Dupuytren's and Ledderhose's diseases."1.30[Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report]. ( Coral, P; Correa Neto, Y; Nóvak, EM; Teive, HA; Werneck, LC; Zanatta, A, 1999)
"Diazepam was the first line treatment in 98 episodes, chlormethiazole and phenytoin were used in 27 and 18 episodes, respectively."1.29Status epilepticus: management and outcome of 107 episodes. ( Martin, PJ; Millac, PA, 1994)
"The latter 2 cases had been treated as epilepsy."1.29[Five cases of paroxysmal sleep disturbances]. ( Ikeno, T; Nagai, H, 1993)
"The combination of West syndrome (WS) and Down syndrome appears not to be coincidental."1.29Early clinical and EEG features of infantile spasms in Down syndrome. ( Cieuta, C; Dulac, O; Guerrini, R; Livet, MO; Plouin, P; Silva, ML, 1996)
"Electroencephalographic (EEG) seizures, grouped and isolated spikes, and significant increases of multineuronal activity (MUA) were elicited by fentanyl, 50 micrograms/kg iv, in these brain structures."1.29Effects of diazepam on fentanyl-induced epileptoid EEG activity and increase of multineuronal firing in limbic and mesencephalic brain structures. ( Antonio-Ocampo, A; Cervantes, M; Chávez-Carrillo, I; Contreras-Gómez, A; Ruelas, R, 1996)
" Newborns and premature infants can metabolize and eliminate diazepam, although the parent drug has a longer half-life and decreased rate of biotransformation to its primary metabolites than in older children and adults."1.27Pharmacokinetics of benzodiazepines and psychostimulants in children. ( Coffey, B; Greenblatt, DJ; Shader, RI, 1983)
"Diazepam was injected by rectal route as an anticonvulsant, using a dose of 0."1.27Rectal diazepam: a clinical and EEG study after a single dose in children. ( Carboni, C; Franzoni, E; Lambertini, A, 1983)
"Carbamazepine, in contrast, has rather a stimulatory action."1.27[Modification of psychophysical performance of the human by anticonvulsants]. ( Meyer, FP; Walther, H, 1987)
"Midazolam is a water soluble 1,4 benzodiazepine which is suitable for intramuscular administration."1.27A pharmacodynamic evaluation of midazolam as an antiepileptic compound. ( Jawad, S; Oxley, J; Richens, A; Wilson, J, 1986)
" The elimination half-life was significantly shorter and the plasma clearance significantly higher in the patients than in the normal volunteers."1.26Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration. ( Dhillon, S; Richens, A, 1981)
"A Consensus Development Conference on Febrile Seizures was held at the National Institutes of Health in USA in May 1980."1.26["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis]. ( Helwig, H; Staudt, F, 1982)
" The pathogenesis points to a multifactorial occurrence caused by the coincidence of an increased dosage of the contrast media, too bed rest time, rising of the contrast media in the spinal cord zone and disturbed liquor fluid circulation and contrast media resorption."1.26[Side reaction after lumbar myelography with dimer-x (author's transl)]. ( Egli, M; Walker, N; Wellauer, J, 1976)
"Recurrent acute respiratory failure in an epileptic subject is described."1.25Respiratory failure as a seizure phenomenon. A case report. ( Malatinský, J; Procházka, M; Sámel, M, 1975)

Research

Studies (530)

TimeframeStudies, this research(%)All Research%
pre-1990305 (57.55)18.7374
1990's82 (15.47)18.2507
2000's58 (10.94)29.6817
2010's53 (10.00)24.3611
2020's32 (6.04)2.80

Authors

AuthorsStudies
Meinke, PT1
Shoop, WL1
Michael, BF1
Blizzard, TA1
Dawson, GR1
Fisher, MH1
Mrozik, H1
Waszkielewicz, AM1
Gunia-Krzyżak, A1
Powroźnik, B1
Słoczyńska, K1
Pękala, E1
Walczak, M1
Bednarski, M1
Żesławska, E1
Nitek, W1
Marona, H1
Lee, KL1
Abiraman, K1
Lucaj, C1
Ollerhead, TA1
Brandon, NJ1
Deeb, TZ1
Maguire, J1
Moss, SJ1
Sharma, S1
Detyniecki, K1
Tarquinio, D7
Dlugos, D4
Wheless, JW6
Desai, J6
Carrazana, E10
Rabinowicz, AL10
Pedroso, J1
Schneider, SE1
Lima-Rezende, CA1
Aguiar, GPS1
Müller, LG1
Oliveira, JV1
Piato, A1
Siebel, AM1
Li, C1
Benbadis, SR1
Misra, SN5
Sperling, MR6
Rao, VR1
Peters, JM3
Davis, C2
de Lima Rosa, G1
Guzzo, EFM1
Nunes, SEB1
Padilha, RB1
Domingues, AM1
Barbosa, BB1
Siqueira, IR1
Coitinho, AS2
Danis, A1
Baranoglu Kilinc, Y1
Torun, IE1
Hanci, F1
Kilinc, E1
Ankarali, H1
de Labra, C1
Cudeiro, J1
Rivadulla, C1
Salahinejad, A1
Meuthen, D1
Attaran, A1
Chivers, DP1
Ferrari, MCO1
Li, J2
Cui, Y1
Li, H1
Hou, X1
Zhao, F1
Zhao, Q1
Zhao, J1
Lin, P1
Meyer, S1
Langer, J1
Poryo, M1
Bay, JG1
Wagenpfeil, S1
Heinrich, B1
Nunold, H1
Strzelczyk, A1
Ebrahimi-Fakhari, D1
Kośmider, K1
Kamieniak, M1
Czuczwar, SJ1
Miziak, B1
Shi, J1
Xin, H1
Shao, Y1
Dai, S1
Tan, N1
Li, Z1
Fei, F1
Wu, D1
Wang, Y1
Ping, Y1
Chen, Z1
O'Hara, K3
Dewar, S1
Bougher, G1
Dean, P1
Puri, V1
Segal, E1
Ramsay, RE1
Becker, DA1
Vazquez, B4
Birnbaum, AK1
Custers, ML1
Vande Vyver, M1
Kaltenböck, L1
Barbé, K1
Bjerke, M1
Van Eeckhaut, A1
Smolders, I1
Lelis, IR1
Krauss, GL1
Lawal, OD1
Meador, KJ1
Hume, AL1
Wen, X1
Segal, EB5
Burman, RJ1
Selfe, JS1
Lee, JH1
van den Berg, M1
Calin, A1
Codadu, NK1
Wright, R1
Newey, SE1
Parrish, RR1
Katz, AA1
Wilmshurst, JM1
Akerman, CJ1
Trevelyan, AJ1
Raimondo, JV1
Bai, YF1
Chiu, M1
Chan, ES1
Axerio-Cilies, P1
Lu, J1
Huh, L1
Connolly, MB1
Guella, I1
Farrer, MJ1
Xu, ZD1
Liu, L1
Demos, M1
Wang, YT1
Le Coz, J1
Chéron, G1
Nabbout, R1
Patteau, G1
Heilbronner, C1
Hubert, P1
Renolleau, S1
Oualha, M1
Steudle, F1
Rehman, S1
Bampali, K1
Simeone, X1
Rona, Z1
Hauser, E1
Schmidt, WM1
Scholze, P1
Ernst, M1
Hogan, RE5
Klein, P1
Miller, I4
Seinfeld, S1
Gelfand, MA1
Heller, AH1
Buan, C1
Slatko, G1
Fedak Romanowski, EM1
McNamara, NA1
Neil, EE1
Gottlieb-Smith, R1
Dang, LT1
Fokoua, AR1
Ndjenda, MK1
Kaptué Wuyt, A1
Tatsinkou Bomba, FD1
Dongmo, AK1
Chouna, R1
Nkeng-Efouet, PA1
Nguelefack, TB1
Biton, V3
Cascino, GD4
Liow, K4
Cook, DF1
Mauney, W2
Erfanparast, A2
Tamaddonfard, E3
Henareh-Chareh, F1
Mesdaghinia, A1
Alinejad, M1
Abed, A1
Heydari, A1
Banafshe, HR1
Nunley, S1
Glynn, P1
Rust, S1
Vidaurre, J1
Albert, DVF1
Patel, AD1
Vigevano, F2
Kirkham, FJ1
Wilken, B1
Raspall-Chaure, M1
Grebla, R1
Lee, D2
Werner-Kiechle, T1
Lagae, L1
Vengerovich, NG1
Drachkova, IM1
Yudin, MA1
Bykov, VN1
Sarana, AM1
Awa, HD1
Chelo, D1
Kinkela, MN1
Ndombo, PO1
Gladwell, D1
Batty, AJ1
Brereton, N1
Tate, E1
Lee, CY1
Liou, HH1
Sánchez Fernández, I1
An, S1
Bergin, AM1
Takeoka, M1
Rotenberg, A1
Kothare, SV1
Riviello, JJ1
Loddenkemper, T1
Coles, LD1
Patterson, EE1
Sheffield, WD1
Mavoori, J1
Higgins, J1
Michael, B1
Leyde, K1
Cloyd, JC3
Litt, B1
Vite, C1
Worrell, GA1
Abou-Khalil, B1
Wheless, J1
Rogin, J1
Wolter, KD1
Pixton, GC1
Shukla, RB1
Sherman, NA1
Sommerville, K1
Goli, V1
Roland, CL1
Lv, Y1
Chu, F1
Meng, H1
Wang, Z1
Cui, L1
Zdebik, AA1
Mahmood, F1
Stanescu, HC1
Kleta, R1
Bockenhauer, D1
Russell, C1
Devinsky, O2
Goldberg, R1
Miles, D1
Bojko, A1
Riviello, J1
Azuma, J1
Nabatame, S1
Nakano, S1
Iwatani, Y1
Kitai, Y1
Tominaga, K1
Kagitani-Shimono, K1
Okinaga, T1
Yamamoto, T1
Nagai, T1
Ozono, K1
Kobayashi, K2
Toda, Y2
Verrotti, A1
Milioni, M1
Zaccara, G1
Luo, Y1
Hu, Q1
Zhang, Q1
Hong, S1
Tang, X1
Cheng, L1
Jiang, L1
Töllner, K1
Twele, F1
Löscher, W5
Tohid, H1
Vieira, V1
Glassmann, D1
Marafon, P1
Pereira, P1
Gomez, R1
Su, Y1
Liu, G1
Tian, F1
Ren, G1
Jiang, M1
Chun, B1
Zhang, Y2
Ye, H1
Gao, D1
Chen, W1
Ikumi, ML1
Muchohi, SN1
Ohuma, EO1
Kokwaro, GO1
Newton, CR1
Kanemoto, K1
Tadokoro, Y1
Oshima, T1
Qashu, F1
Figueiredo, TH1
Aroniadou-Anderjaska, V1
Apland, JP1
Braga, MF1
Bum, EN2
Taiwe, GS1
Nkainsa, LA1
Moto, FC1
Seke Etet, PF1
Hiana, IR1
Bailabar, T1
Seyni, P1
Rakotonirina, A1
Rakotonirina, SV1
Luongo, R1
Oliveira, DA1
Lebrun, I1
Sandoval, MR1
Singh, D1
Goel, RK1
Micale, V1
Cristino, L1
Tamburella, A1
Petrosino, S1
Leggio, GM1
Drago, F1
Di Marzo, V1
Tilz, C1
Resch, R1
Hofer, T1
Eggers, C1
Tyzio, R1
Khalilov, I1
Represa, A2
Crepel, V1
Zilberter, Y1
Rheims, S1
Aniksztejn, L1
Cossart, R1
Nardou, R1
Mukhtarov, M1
Minlebaev, M1
Epsztein, J1
Milh, M1
Becq, H1
Jorquera, I1
Bulteau, C1
Fohlen, M1
Oliver, V1
Dulac, O2
Dorfmüller, G1
Delalande, O1
Ben-Ari, Y2
Khazipov, R1
de Haan, GJ1
van der Geest, P1
Doelman, G1
Bertram, E1
Edelbroek, P1
Cysneiros, RM1
Ferrari, D1
Arida, RM1
Terra, VC1
de Almeida, AC1
Cavalheiro, EA6
Scorza, FA2
Raza, ML1
Zeeshan, M1
Ahmad, M1
Shaheen, F1
Simjee, SU1
Wolf, P1
Holsti, M1
Dudley, N1
Schunk, J1
Adelgais, K1
Greenberg, R1
Olsen, C1
Healy, A1
Firth, S1
Filloux, F1
Fusco, L1
Specchio, N1
Ciofetta, G1
Longo, D2
Trivisano, M1
Ratsimbazafy, V1
Andrianabelina, R1
Randrianarisona, S1
Preux, PM1
Odermatt, P1
Chiang, LM1
Wang, HS1
Shen, HH1
Deng, ST1
Tseng, CH1
Chen, YI1
Chou, ML1
Hung, PC1
Lin, KL1
Chen, WB1
Gao, R1
Su, YY1
Zhao, JW1
Zhang, YZ1
Wang, L1
Ren, Y1
Fan, CQ1
Venturin, GT1
Greggio, S1
Marinowic, DR1
Zanirati, G1
Cammarota, M1
Machado, DC1
DaCosta, JC1
Jeon, D1
Chu, K1
Lee, ST1
Jung, KH1
Kang, KM1
Ban, JJ1
Kim, S1
Seo, JS1
Won, CH1
Kim, M1
Lee, SK1
Roh, JK1
Zhu, G1
Yoshida, S1
Migita, K1
Yamada, J1
Mori, F1
Tomiyama, M1
Wakabayashi, K1
Kanematsu, T1
Hirata, M1
Kaneko, S1
Ueno, S1
Okada, M2
Tan, GH1
Liu, YY1
Hu, XL1
Yin, DM1
Mei, L1
Xiong, ZQ1
Reddy, DS3
Gould, J1
Gangisetty, O1
Sayers, KW1
Nguyen, PT1
Blair, RE1
Sim-Selley, LJ1
DeLorenzo, RJ1
Hamzeh Gooshchi, N1
Seiednejad-Yamchi, S1
Okomolo, FC1
Mbafor, JT1
Kouemou, N1
Kandeda, AK1
Talla, E1
Dimo, T1
Rakotonirira, A1
Rakotonirira, SV1
Albus, K1
Wahab, A1
Heinemann, U1
Senthilraja, M1
Alagarsamy, V1
Kazmi, I1
Afzal, M1
Gupta, G1
Anwar, F1
Funnell, M1
Ranta, A1
Hayashi, Y1
Inoue, T1
Oka, M1
Ohtsuka, Y1
Gualtieri, F1
Marinelli, C1
Pugnaghi, M1
Nichelli, PF1
Meletti, S1
Biagini, G1
da Cruz, GM1
Felipe, CF1
da Costa, MA1
Tavares, AF1
Menezes, ML1
de Andrade, GM1
Leal, LK1
Brito, GA1
da Graça Naffah-Mazzacoratti, M1
de Barros Viana, GS1
Mussulini, BH1
Leite, CE1
Zenki, KC1
Moro, L1
Baggio, S1
Rico, EP1
Rosemberg, DB1
Dias, RD1
Souza, TM1
Calcagnotto, ME1
Campos, MM1
Battastini, AM1
de Oliveira, DL1
Araki, T1
Simon, RP1
Taki, W1
Lan, JQ1
Henshall, DC1
Bowser, DN1
Wagner, DA1
Czajkowski, C1
Cromer, BA1
Parker, MW1
Wallace, RH1
Harkin, LA1
Mulley, JC1
Marini, C1
Berkovic, SF1
Williams, DA1
Jones, MV1
Petrou, S1
Delmont, E1
Bourg, V1
Thomas, P1
Murphy, A1
Wilbur, K1
Sterrick, M1
Foley, J1
Bråthen, G1
ROSA, JJ1
MIRVILLANUE, VA1
KALINA, RK1
ARRIGO, A2
SAVOLDI, F1
TARTARA, A2
BARSA, JA1
SAUNDERS, JC1
BARRERAPEREZ, S1
HARDER, A1
WEINBERG, WA1
HARWELL, JL1
GALAMBOS, M2
BARTEN, HH1
GASTAUT, H8
NAQUET, R3
POIRE, R2
TASSINARI, CA3
Hansen, SL1
Sperling, BB1
Sánchez, C1
Okumura, A1
Ishiguro, Y1
Sofue, A1
Suzuki, Y1
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Kubota, T1
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Pellock, JM5
Yamashita, H1
Ohno, K1
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Sakamoto, S1
Yamaguchi, T1
Suzuki, K1
Kobayashi, M1
Tokue, A1
Püst, B1
Buznego, MT1
Pérez-Saad, H1
Hosseinzadeh, H1
Parvardeh, S1
Nassiri-Asl, M1
Mansouri, MT1
Shinnar, S2
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Friedman, L1
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Lander, ES1
Nadeau, J1
Cucullo, L1
Hossain, M1
Rapp, E1
Manders, T1
Marchi, N1
Janigro, D1
Engelhorn, T1
Weise, J1
Hammen, T1
Bluemcke, I1
Hufnagel, A1
Doerfler, A1
Marqués-Marí, AI1
Nacher, J1
Crespo, C1
Gutièrrez-Mecinas, M1
Martínez-Guijarro, FJ1
Blasco-Ibáñez, JM1
Kiel, S1
McCullough, K1
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Ali, N1
Youssef, FF1
Stone, TW1
Terry, D1
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Kryzhanovskiĭ, GN3
Asano, T1
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Dhillon, S6
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Richens, A10
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Julius, DA1
Kaminer, Y1
Munitz, H1
Addy, DP1
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de Campos, CJ1
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Zanatta, A1
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Werneck, LC1
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Wichmann, J1
Dautzenberg, FM1
Moreau, JL1
Ouagazzal, AM1
Martin, JR1
Lundstrom, K1
Cesura, AM1
Poli, SM1
Roever, S1
Kolczewski, S1
Adam, G1
Kilpatrick, G1
Stein, AG1
Blum, DE1
Drachev, A1
Dunworth, SJ1
Mead, AN1
Stephens, DN1
Khanna, N1
Bhalla, S1
Rogawski, MA2
Yoon, Y1
Jagoda, A1
Bazyan, AS1
Zhulin, VV1
Karpova, MN1
Klishina, NY1
Glebov, RN1
Lin, J1
Ritchie, GD1
Stenger, DA1
Nordholm, AF1
Pancrazio, JJ1
Rossi, J1
Temkin, NR1
Vanaja, P1
Jayakumar, AR1
Tiffin, PA1
Perini, AF1
Bianchi, MT1
Song, L1
Zhang, H1
Macdonald, RL1
Bohlen, N1
Hertl, M1
Kristof, M1
Servít, Z1
Hopkins, A1
Scambler, G1
Gromov, SA1
Rowan, AJ1
Pippenger, CE2
McGregor, PA1
French, JH1
Speciali, GG1
Lison, MP2
Kurokawa, T1
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Mitsudome, A1
Shibata, R1
Takashima, S1
Goya, N1
Azcarate, CL1
Lechner, H1
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Laidlaw, J1
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Kutt, H3
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Buti Cossi, D1
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Bardini, MR1
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Bruni, J1
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Wilkinson, HA2
Lumholtz, IB1
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Passarge, C1
Faugier-Grimaud, S1
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Fishman, RA1
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Gustaut, H1
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Eadie, MJ2
Wakayama, S1
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Maida, C1
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Trimble, M1
Nicol, CF2
Malatinský, J1
Procházka, M3
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Huang, Z1
De Sarro, GB1
Rotiroti, D1
Gratteri, S1
Sinopoli, S1
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Sander, JW2
Nutt, DJ3
Shorvon, SD2
Dudkin, AO1
Shanmugasundaram, ER1
Akbar, GK1
Shanmugasundaram, KR1
Anai, T1
Hirota, Y1
Oga, M1
Yoshimatsu, J1
Miyakawa, I1
De Negri, M1
Gaggero, R1
Veneselli, E1
Pessagno, A1
Baglietto, MG1
Pallecchi, A1
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Titulaer, MN1
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Klosterkötter, J1
Penin, H1
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de Vries, L1
Dubowitz, LM1
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van Luijtelaar, EL1
Bromfield, EB1
Dambrosia, J1
Nice, FJ1
Theodore, WH1
Baran, H1
Hörtnagl, H1
Hornykiewicz, O1
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Oberholzer, DJ1
Rennert, H1
McGeer, E1
McGeer, PL1
Jonesco-Benaiche, N1
Jasmin, JR1
Davis, LG1
Bordiukov, MM1
Nikushkin, EV1
Bogdanova, ED1
Prilipko, LL1
Ogata, N1
Matsuo, T1
Inoue, M1
Nolting, B1
Janicki, PK1
Gumulka, SW1
Rewekant, M1
Pisarski, W1
Jedrzejowska, H1
De Domenico, P1
Gallitto, G1
Musolino, R1
Bonanzinga, M1
Troilo, G1
Di Perri, R1
Sacchi, C1
Meyer, FP1
Walther, H1
Pedder, SC1
Wilcox, R1
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Marescaux, C1
Vergnes, M1
Klebs, K1
Klein, M1
Martin, P1
Portet, C1
Maitre, L1
Schmutz, M1
Jawad, S2
Yuen, WC1
De Riu, PL1
Mameli, O1
Tolu, E1
Lutz, EG1
Lutz, MB1
Lutz, GE1
Razdan, S1
Koul, RL1
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Martyniuk, VIu1
Drake, ME1
Farrell, K1
Wilson, J2
Crichlow, EC1
Mishra, PR1
Frey, HH1
Godbout, R1
Montplaisir, J1
Rouleau, I1
Sobotka, P1
Navrátil, L1
Herranz Fernández, JL1
Tudor, I2
Falconer, MA1
Davidson, S1
Penry, JK2
Kraft, D1
Schaefer, K1
Bochentin, W1
von Herrath, D1
Opitz, A1
Koeppe, P1
Tyrer, JH1
Laitinen, L1
Toivakka, E1
Aleksandrovskiĭ, IuA2
But, PG1
Kaplunskiĭ, GD1
poltorakov, AP1
Chibrikin, VM1
Parsonage, M2
Pomina, AC1
Tarlau, M1
Berman, AJ1
Jaffe, R1
Christoff, NJ1
Ravenna, C1
Lion, P1
Ebe, M2
Meier-Ewert, K1
Broughton, R2
Dalby, MA1
Kurtz, D2
Tempe, JD2
Weber, M2
Feuerstein, J2
Reeb, M2
Mantz, JM2
Otto, JL1
Schlagenhauf, G1
Killam, KF1
Killam, EK1
Catier, J2
Lavy, S1
Assael, M1
Hershon, HI1
Meier-Ewert, KH1
Niedermeyer, E4
Baird, HW1
van Duijn, H2
Leonidas, JC1
Brill, PW1
Waldman, N1
Browne, TR1
Livingston, S1
Ferngren, HG1
Forman, PM1
Saper, JR1
Lossing, JH1
Greene, CA1
Rao, VS1
Papeschi, R1
Molina-Negro, P1
Sourkes, TL1
Erba, G1
Schreiber, KA1
Gibbs, FA1
Anderson, EM1
Canger, R1
Borenstein, P1
Champion, C1
Cujo, P1
Gekière, F1
Olivenstein, C1
Kramarz, P1
Fukuyama, Y1
Millichap, JG1
Freeman, JM1
Lietman, PS1
Hooshmand, H1
Lehmann, HE1
Ban, TA1
Friedlander, WJ1
Gardner-Thorpe, C1
Parsonage, MJ1
Toothill, C1
Hertrich, O1
Leibovitz, U1
Ritter, G1
Louis, S1
Josephson, DA1
Abraham, U1
Cavazzuti, GB1
Noble, IM1
Jansen, F1
Martinius, J1
Matthes, A1
Siris, JH1
Werner, WL1
Masland, RL1
Saletu, B1
Saletu, M1
Itil, T1
Scamoni, C1
Presazzi, A1
Tharp, BR1
Uphold, JD1
Prokudin, VN1
Martin, D2
Hirt, HR2
Lombroso, CT3
Stark, LG1
Edmonds, HL1
Keesling, P1
Burnett, LL1
Struve, FA1
Chien, C1
Keegan, D1
Visser, SL1
Prior, PF1
Maclaine, GN1
Scott, DF1
Laurance, BM1
Hohenauer, L1
Zsadányi, O1
Molnár, C1
Novotný, P1
Langevin, P1
Panther, W1
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Lowis, GR1
West, JR1
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Garibay, E1
Padilla, J1
Booker, HE1
Celesia, GG1
Chemburkar, JA1
Ravindranath, S1
Desai, AD1
Mace, JW1
Conomy, JP1
Holmquest, DL1
Launey, WS1
Barksdale, CR1
Hill, RM1
Verniaud, WM1
Horning, MG1
McCulley, LB1
Morgan, NF1
Wilson, JT1
Carter, S2
Gold, A2
Angst, J1
Ristić, J1
Trolle, E1
Müller, HR1
Klingler, M1
Kaeser, HE2
Wurmser, P1
Henriksen, PB1
Scharfetter, C1
Schmoigl, S1
Bell, DS3
Declerck, A1
Tutton, JC2
Smith, BH1
Elian, M1
Degen, R1
Moe, PG1
Geller, M1
Christoff, N1
Dowzenko, A1
Huber, Z1
Zieliński, JJ1
Borkowska, Z1
Mazurkowa, K1
Wojakowski, A1
Weinmann, HM1
Máttyus, A1
Halász, A1
Kovács, J1
Garofalo, P1
Bonenti, G1
De Petris, MP1
Whitty, CW1
Oxbury, JM1
Bower, BD1
Finavera, L1
Mascetti, A1
Zamberletti, P1
Rosenmayr, F1
Groh, C1
Cendrowski, W1
Majkowski, J1
Vajnorský, J1
Healy, TE1
Edmondson, HD1
Hall, N1
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Vitols, A1
Kamianov, IM1
Ledić, P1
Antonćić, N1
Sepcić, J1
Ekstedt, J1
Speciali, JG1
Utz, W1
Spehlmann, R1
Daniels, JC1
Chang, CM1
Gordon, NS1
McMorris, S1
McWilliam, PK1
Royer, J1
Hess, R1
Nathan, PW1
Averill, DR1
Sourek, K2
Trávnícek, V1
Brett, EM1
Goddard, P1
Lokare, VG1
Gumpert, J1
Hansotia, P1
Upton, A1
Hajnsek, F1
Gubarev, N1
Bogolepov, NK1
Burd, GS1
Fedin, AI1
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Tresise, PC1
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Magyar, I1
Schwartz, JF1
Howard, FM1
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Eisenmann, M1
Friedel, B1
Reimer, F1
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Shibuki, K1
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Hollis, DA1
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Gerin, P1
Fischer, G1
Soulayrol, R1
Oller-Daurella, L1
Ferrari, G1
Tajoli, E1
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Clinical Trials (10)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
An Open-Label, Repeat-Dose Pharmacokinetics Study of NRL-1 in Epilepsy Subjects Under Seizure and Normal Conditions[NCT02724423]Phase 157 participants (Actual)Interventional2016-06-30Completed
A 12-Month Open-Label, Repeat-Dose Safety Study of NRL-1 in Epilepsy Subjects (DIAZ.001.05)[NCT02721069]Phase 3175 participants (Actual)Interventional2016-04-11Completed
Non-inferiority Prospective Randomized Trial of Acetazolamide Versus Diazepam in Patients With Continuous Spike and Wave in Sleep (CSWS)/Landau Kleffner Syndrome (LKS)[NCT02904265]Phase 2/Phase 33 participants (Actual)Interventional2016-09-30Terminated (stopped due to Lack of enrollment)
Big Data Construction and Biological Etiological Epidemiology Study of Children Epilepsy in China[NCT02969213]10,000 participants (Anticipated)Observational2016-11-30Not yet recruiting
A Phase 3, Randomized, Double-blind, Parallel, Placebo-controlled, Multicenter Study, With Optional Open-label Continuation, Of The Efficacy And Safety Of Vanquix(tm) Auto-injector (Diazepam Injection) For The Management Of Selected, Refractory, Patients [NCT00319501]Phase 3234 participants (Actual)Interventional2006-01-31Completed
The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822]550 participants (Anticipated)Observational2022-02-18Recruiting
Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612]Phase 2358 participants (Actual)Interventional2006-06-30Completed
Trial of Intracerebral Infusion in Patients With Medically Intractable Epilepsy[NCT00005925]Phase 13 participants (Actual)Interventional2000-06-23Terminated
Rapid Oral Treatment of Cluster Epileptic Seizures. Efficacy Assessment of Levetiracetam in Cluster Seizures.[NCT00376766]Phase 3112 participants (Anticipated)Interventional2007-02-28Terminated (stopped due to recruitment recruitment recruitment recruitment difficulties)
NEED: Neuromed Epilepsy EEG Database. A Large Database of Electroencephalographic (EEG) Signals of Epilepsy Patients for Research Community.[NCT04647825]200 participants (Anticipated)Observational2021-04-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cmax of Diazepam After Single Intranasal Doses of NRL-1 (Diazepam Nasal Spray) Administered to Epilepsy Subjects During the Ictal or Peri-ictal Period

Evaluate the pharmacokinetics (PK), in terms of Cmax, of diazepam following a single intranasal dose of NRL-1 (diazepam nasal spray) administered to epilepsy subjects in the ictal or peri-ictal state (defined as either during or immediately following a seizure), where the seizure involved motor activity or alteration of awareness compared with the normal (non-seizing) state. The epileptic condition (ictal/peri-ictal, interictal) had minimal impact on diazepam nasal spray pharmacokinetics. (NCT02724423)
Timeframe: Blood samples were obtained at 0, 15, 30, and 45 minutes, and 1, 1.25, 1.5, 1.75, 2, 3, 4, 5, and 6 hours after dosing. If feasible, samples were drawn at 8 and 12 hours post-dose but were excluded from PK analysis.

Interventionng/mL (Geometric Mean)
NRL-1 ICTAL/PERI-ICTAL135
NRL-1 INTER-ICTAL153

The AUC of Diazepam After Single Intranasal Doses of NRL-1 (Diazepam Nasal Spray) Administered to Epilepsy Subjects During the Ictal or Peri-ictal Period

Evaluate the pharmacokinetics (PK), in terms of AUC, of diazepam following a single intranasal dose of NRL-1 (diazepam nasal spray) administered to epilepsy subjects in the ictal or peri-ictal state (defined as either during or immediately following a seizure), where the seizure involved motor activity or alteration of awareness compared with the normal (non-seizing) state. The epileptic condition (ictal/peri-ictal, interictal) had minimal impact on diazepam nasal spray pharmacokinetics. (NCT02724423)
Timeframe: Blood samples were obtained at 0, 15, 30, and 45 minutes, and 1, 1.25, 1.5, 1.75, 2, 3, 4, 5, and 6 hours after dosing. If feasible, samples were drawn at 8 and 12 hours post-dose but were excluded from PK analysis.

Interventionng*hr/mL (Geometric Mean)
NRL-1 ICTAL/PERI-ICTAL435
NRL-1 INTER-ICTAL502

Number of Participants Who Received NRL-1 (Valtoco)

Assess the number of participants who received at least one dose of NRL-1 (Valtoco) during the study and comprised the safety population. (NCT02721069)
Timeframe: 12 months

InterventionParticipants (Count of Participants)
NRL-1 5mg9
NRL-1 10mg54
NRL-1 15 mg46
NRL-1 20mg54

Short-term Tolerability of Acetazolamide vs Diazepam

Expect improved side effect profile of acetazolamide compared to diazepam at short-term follow up (NCT02904265)
Timeframe: 4-8 weeks of start of medications

InterventionParticipants (Count of Participants)
Diazepam1
Acetazolamide2

Mean Score on Caregiver Global Treatment Assessment During the Double-blind Period

Caregiver global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes and is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) is defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: Assessments completed at the end of each treated episode of ARS in the Double-blind Period

InterventionUnits on a scale (Mean)
Diazepam6.2
Placebo5.5

Mean Score on Caregiver Global Treatment Assessment During the Open-label Period

Caregiver global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes and is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) is defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: Assessments completed at the end of each treated episode of ARS in the Open-label Period

InterventionUnits on a scale (Mean)
Diazepam6.78

Mean Score on Physician Global Treatment Assessment During the Double-blind Period

Physician global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes. The physician global evaluation is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: At Visit 2 and subsequent visits in the Double-blind Period

InterventionUnits on a scale (Mean)
Diazepam6.3
Placebo5.5

Mean Score on Physician Global Treatment Assessment During the Open-label Period

Physician global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes and is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) is defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From Visit 2 and subsequent visits in the Open-label Period to discharge or study termination

InterventionUnits on a scale (Mean)
Diazepam6.87

Number of Participants Requiring Emergency Department Visits During the Double-blind Period

Any use of emergency treatment (such as an emergency room visit) was recorded in the patient's diary, along with the date, time, and reason for the emergency treatment. Emergency department visits required some type of rescue action taken, other than the visit itself. An episode of acute repetitive seizures (ARS) was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From 15 minutes to 12 hours following study drug administration for onset of an episode of ARS during the Double-blind Period

InterventionParticipants (Number)
Diazepam2
Placebo4

Number of Participants Requiring Emergency Department Visits During the Open-label Period

Any use of emergency treatment (such as an emergency room visit) was recorded in the patient's diary, along with the date, time, and reason for the emergency treatment. Emergency department visits required some type of rescue action taken, other than the visit itself. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for onset of an episode of ARS during the Open-label Period

InterventionParticipants (Number)
Diazepam13

Number of Participants Requiring Rescue Medical Care Other Than Medication or Emergency Department Visits During the Open-label Period

Other rescue medical care consisted of care other than rescue medication or emergency department visits. Each patient's specific criteria for seizure and an episode of acute repetitive seizure (ARS) were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for onset of an episode of ARS during the Open-label Period

InterventionParticipants (Number)
Diazepam5

Number of Participants Requiring Rescue Medical Care Other Than Rescue Medication or Emergency Department Visits During the Double-blind Period

Other rescue medical care consisted of care other than rescue medication or emergency department visits. Each patient's specific criteria for seizure and an episode of acute repetitive seizure (ARS) were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. An episode of ARS was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From 15 minutes to 12 hours following study drug administration for an episode of ARS during the Double-blind Period

InterventionParticipants (Number)
Diazepam0
Placebo2

Number of Participants Requiring Rescue Medication During the Double-blind Period

If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the acute repetitive seizure (ARS) episode. Each patient's specific criteria for seizure and an episode of ARS were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. An episode of ARS was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From 15 minutes to 12 hours following study drug administration for an episode of ARS during the Double-blind Period

InterventionParticipants (Number)
Diazepam14
Placebo24

Number of Participants Requiring Rescue Medication During the Open-label Period

Each patient's specific criteria for seizure and an episode of acute repetitive seizure (ARS) were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the ARS episode. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration during the Open-label Period

InterventionParticipants (Number)
Diazepam39

Percentage of Participants With an Event (Next Seizure or Rescue Medication) During the Open-label Period

An event was defined as an episode of or required rescue medication for an episode of acute repetitive seizures (ARS) within 15 minutes to 12 hours following study drug administration. Patients without an ARS event were censored at 12 hours. Diaries were provided; if no diary was returned, or the diary did not provide answers to questions about seizures and rescue during the 12-hour follow-up period, the patient was considered censored as of 15 minutes past the treatment time, unless another contact was documented. If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the ARS episode. Patients and their caregivers were trained to recognize the onset of an episode of ARS and when and how to administer study drug. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for an episode of ARS during the Double-blind Period

InterventionPercentage of participants (Number)
Diazepam22.4

Time to Next Seizure or Rescue Medication During the Double-blind Period (Kaplan-Meier 50th Percentile)

An event was defined as an episode of or required rescue medication for an episode of acute repetitive seizures (ARS) within 15 minutes to 12 hours following study drug administration. Patients without an ARS event were censored at 12 hours. Diaries were provided; if no diary was returned, or the diary did not provide answers to questions about seizures and rescue during the 12-hour follow-up period, the patient was considered censored as of 15 minutes past the treatment time, unless another contact was documented. If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the ARS episode. Patients and their caregivers were trained to recognize the onset of an episode of ARS and when and how to administer study drug. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for an episode of ARS during the Double-blind Period

InterventionHours (Median)
Diazepam5.92
PlaceboNA

Length of Seizure After Study Medication Administration

Length of seizure. (NCT00326612)
Timeframe: 24 hours

InterventionMinutes (Median)
Intranasal Midazolam3.0
Rectal Diazepam4.3

Number of Patients Needed to be Seen or Treated in the Emergency Department for Their Seizure and Use of Study Medication.

(NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam21
Rectal Diazepam17

Number of Patients That Were Admitted to the Hospital After Their Seizure and Use of Study Medication.

(NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam4
Rectal Diazepam3

Number of Patients Who Had a Repeat Seizure Within 12 Hours After Their Seizure Who Used Study Medication

(NCT00326612)
Timeframe: 12 hours

Interventionparticipants (Number)
Intranasal Midazolam1
Rectal Diazepam1

Number of Patients Who Needed Additional Medication to Treat the Seizure in the Emergency Department Within 24 Hours

(NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam5
Rectal Diazepam5

Respiratory Depression Requiring Intubation

Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam1
Rectal Diazepam0

Respiratory Depression Requiring Oxygen at Discharge From the Emergency Department.

Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours

Interventionparticipants (Number)
Intranasal Midazolam3
Rectal Diazepam1

Reviews

56 reviews available for diazepam and Aura

ArticleYear
Rescue therapies in epilepsy.
    Current opinion in neurology, 2022, 04-01, Volume: 35, Issue:2

    Topics: Administration, Intranasal; Adult; Anticonvulsants; Diazepam; Epilepsy; Humans; Seizures

2022
Effects of common antiepileptic drugs on teleost fishes.
    The Science of the total environment, 2023, Mar-25, Volume: 866

    Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Ecosystem; Epilepsy; Fishes; Humans

2023
Effects of tranquilization therapy in elderly patients suffering from chronic non-communicable diseases: A meta-analysis.
    Acta pharmaceutica (Zagreb, Croatia), 2023, Mar-01, Volume: 73, Issue:1

    Topics: Aged; Diazepam; Epilepsy; Humans; Noncommunicable Diseases; Prospective Studies; Randomized Controll

2023
Second Generation of Antiepileptic Drugs and Oxidative Stress.
    International journal of molecular sciences, 2023, Feb-15, Volume: 24, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Diazepam; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; Hum

2023
Overcoming barriers to the management of seizure clusters: ease of use and time to administration of rescue medications.
    Expert review of neurotherapeutics, 2023, Volume: 23, Issue:5

    Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Epilepsy; Epilepsy, Generalized; Humans; Nasa

2023
Acute Abortive Therapies for Seizure Clusters in Long-Term Care.
    Journal of the American Medical Directors Association, 2023, Volume: 24, Issue:8

    Topics: Aged; Anticonvulsants; Diazepam; Epilepsy; Humans; Long-Term Care; Status Epilepticus; United States

2023
Seizure Rescue Medications for Out-Of-Hospital Use in Children.
    The Journal of pediatrics, 2021, Volume: 229

    Topics: Administration, Intranasal; Administration, Rectal; Anticonvulsants; Benzodiazepines; Child; Diazepa

2021
Safety and efficacy of diazepam autoinjector for the management of epilepsy.
    Expert review of neurotherapeutics, 2015, Volume: 15, Issue:2

    Topics: Acute Disease; Administration, Buccal; Animals; Anticonvulsants; Diazepam; Epilepsy; Humans

2015
Anti-glutamic acid decarboxylase antibody positive neurological syndromes.
    Neurosciences (Riyadh, Saudi Arabia), 2016, Volume: 21, Issue:3

    Topics: Autoantibodies; Baclofen; Cerebellar Ataxia; Diazepam; Epilepsy; GABA Modulators; GABA-B Receptor Ag

2016
[Diagnosis and treatment of epilepsy in the field of psychiatry].
    Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica, 2008, Volume: 110, Issue:7

    Topics: Adult; Anticonvulsants; Carbamazepine; Diazepam; Electroencephalography; Epilepsy; Female; Humans; M

2008
[Alcohol and epilepsy].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2003, May-29, Volume: 123, Issue:11

    Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy;

2003
Safety of Diastat, a rectal gel formulation of diazepam for acute seizure treatment.
    Drug safety, 2004, Volume: 27, Issue:6

    Topics: Acute Disease; Administration, Rectal; Anticonvulsants; Diazepam; Epilepsy; Gels; Humans

2004
[Febrile seizures--an update].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 2004, Volume: 23, Issue:8

    Topics: Administration, Oral; Administration, Rectal; Age Factors; Analgesics, Non-Narcotic; Anticonvulsants

2004
Emergency management of seizures in the school setting.
    The Journal of school nursing : the official publication of the National Association of School Nurses, 2007, Volume: 23, Issue:3

    Topics: Administration, Rectal; Anticonvulsants; Child; Diazepam; Emergencies; Epilepsy; Humans; Nursing Rec

2007
[Benzodiazepines in the treatment of epilepsy].
    L'Encephale, 1983, Volume: 9, Issue:4 Suppl 2

    Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobazam

1983
[Use of phenobarbital in febrile convulsive crisis].
    Anales espanoles de pediatria, 1983, Volume: 18, Issue:2

    Topics: Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Nervous System Diseases; Phenobarbital; Recurr

1983
Pharmacological principles in the long-term treatment of epilepsy.
    European neurology, 1981, Volume: 20, Issue:4

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Kinetics; Long

1981
Seizure disorders.
    The Veterinary clinics of North America. Small animal practice, 1980, Volume: 10, Issue:1

    Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephob

1980
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
    Epilepsia, 1996, Volume: 37 Suppl 1

    Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea

1996
Seizures in dogs.
    The Veterinary clinics of North America. Small animal practice, 1996, Volume: 26, Issue:4

    Topics: Animals; Anticonvulsants; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Phenobarb

1996
New drug therapy for acute seizure management.
    Seminars in pediatric neurology, 1997, Volume: 4, Issue:1

    Topics: Acute Disease; Anticonvulsants; Child; Diazepam; Epilepsy; Humans; Phenytoin; Prodrugs; Seizures; Va

1997
Management and treatment of febrile seizures.
    Current problems in pediatrics, 1997, Volume: 27, Issue:1

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Blood Chemical Analysis; Child, Preschool; Diagnosis, Dif

1997
Advances in the medical treatment of epilepsy.
    Annual review of medicine, 1998, Volume: 49

    Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approv

1998
[Rectal diazepam for treatment and prevention of seizures in children].
    Harefuah, 1998, Jan-15, Volume: 134, Issue:2

    Topics: Administration, Rectal; Anticonvulsants; Child; Diagnosis, Differential; Diazepam; Epilepsy; Humans;

1998
Antiepileptic drug therapy.
    Clinical techniques in small animal practice, 1998, Volume: 13, Issue:3

    Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Cyclohexanecarboxylic Acid

1998
Seizure management in pediatric patients for the nineties.
    Pediatric annals, 1998, Volume: 27, Issue:10

    Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; F

1998
Febrile seizures: treatment and prognosis.
    Epilepsia, 2000, Volume: 41, Issue:1

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Cognition; Diazepam; Epilepsy; Humans; Intelligence; Prog

2000
New antiepileptic drugs and preparations.
    Emergency medicine clinics of North America, 2000, Volume: 18, Issue:4

    Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids;

2000
[Febrile convulsions, Treatment and prognosis].
    Ugeskrift for laeger, 2001, Feb-19, Volume: 163, Issue:8

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe

2001
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
    Epilepsia, 2001, Volume: 42, Issue:4

    Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic;

2001
Minor tranquilizers in the treatment of aggression.
    The Journal of nervous and mental disease, 1975, Volume: 160, Issue:2-1

    Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Depression; Diazepam; Epilepsy;

1975
[Prevention of recurrences and of epilepsy in febrile convulsions. Protocol of the Pediatric Clinic of the Florence and preliminary results].
    Minerva pediatrica, 1979, Nov-30, Volume: 31, Issue:22

    Topics: Age Factors; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence;

1979
Pharmacological prophylaxis in the kindling model of epilepsy.
    Archives of neurology, 1977, Volume: 34, Issue:7

    Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba

1977
Management of seizure disorders: selected aspects. Part I.
    The Journal of pediatrics, 1976, Volume: 89, Issue:4

    Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Child; Chromatography, Gas; Chromatography,

1976
Neurologic disorders in renal failure (first of two parts).
    The New England journal of medicine, 1976, Jan-15, Volume: 294, Issue:3

    Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc

1976
[Epileptic psychoses and their drug treatment].
    Fortschritte der Neurologie-Psychiatrie, 1989, Volume: 57, Issue:2

    Topics: Anticonvulsants; Antipsychotic Agents; Clonazepam; Diazepam; Epilepsy; Humans; Neurocognitive Disord

1989
A sound basis for the use of benzodiazepines.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1985, Oct-26, Volume: Suppl

    Topics: Anesthesia; Anti-Anxiety Agents; Anxiety Disorders; Diazepam; Drug Utilization; Epilepsy; Humans; In

1985
Febrile seizures.
    Emergency medicine clinics of North America, 1987, Volume: 5, Issue:4

    Topics: Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Female

1987
Use of barbiturates and benzodiazepines in treatment of epilepsy.
    Neurologic clinics, 1986, Volume: 4, Issue:3

    Topics: Adult; Barbiturates; Benzodiazepines; Child; Clonazepam; Clorazepate Dipotassium; Diazepam; Epilepsy

1986
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
    Journal of veterinary pharmacology and therapeutics, 1985, Volume: 8, Issue:3

    Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E

1985
Usefulness of blood levels of antiepileptic drugs.
    Archives of neurology, 1974, Volume: 31, Issue:5

    Topics: Anticonvulsants; Carbamazepine; Chloramphenicol; Chlordiazepoxide; Chlorpromazine; Chromatography, G

1974
[Psychopharmacological agents in children].
    Monatsschrift fur Kinderheilkunde, 1973, Volume: 121, Issue:3

    Topics: Acetylcholine; Aminobutyrates; Antipsychotic Agents; Cerebral Palsy; Child; Chlordiazepoxide; Diazep

1973
Plasma levels of anticonvulsants.
    Australian and New Zealand journal of medicine, 1973, Volume: 3, Issue:3

    Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Barbiturates; Blood Proteins; Carbamazepine;

1973
Benzodiazepines in the treatment of epilepsy. A review.
    Epilepsia, 1973, Volume: 14, Issue:3

    Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec

1973
[Diagnosis and treatment of epilepsy].
    Nihon Shonika Gakkai zasshi. Acta paediatrica Japonica, 1968, Oct-01, Volume: 72, Issue:10

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Anticoag

1968
A basic approach to the understanding of seizures and the mechanism of action and metabolism of anticonvulsants.
    Advances in pediatrics, 1973, Volume: 20, Issue:0

    Topics: Acetylcholine; Aminobutyrates; Anticonvulsants; Calcium; Cell Membrane Permeability; Depression, Che

1973
Toxic effects of anticonvulsants: general principles.
    Pediatrics, 1974, Volume: 53, Issue:4

    Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weig

1974
Epilepsy.
    Progress in neurology and psychiatry, 1968, Volume: 23

    Topics: Adolescent; Animals; Barbiturates; Brain Neoplasms; Cell Membrane Permeability; Central Nervous Syst

1968
Recent progress in epilepsy. Diagnostic procedures and treatment.
    California medicine, 1973, Volume: 119, Issue:1

    Topics: Anticonvulsants; Brain Neoplasms; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Temporal Lob

1973
The benzodiazepines.
    Texas medicine, 1973, Volume: 69, Issue:6

    Topics: Alcoholism; Anesthesia; Animals; Antidepressive Agents; Benzazepines; Diazepam; Epilepsy; Heart Dise

1973
[Features of the clinical effect of benzodiazepine derivatives (according to the findings of comparative studies). Review of the literature].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1973, Volume: 73, Issue:2

    Topics: Adjustment Disorders; Aggression; Animals; Antisocial Personality Disorder; Barbiturates; Benzazepin

1973
The treatment of status epilepticus.
    Pediatrics, 1974, Volume: 53, Issue:4

    Topics: Anti-Bacterial Agents; Anticonvulsants; Barbiturates; Brain Edema; Central Nervous System Diseases;

1974
The value of EEG study in minimal brain dysfunction.
    Journal of clinical psychology, 1974, Volume: 30, Issue:4

    Topics: Attention Deficit Disorder with Hyperactivity; Child Behavior Disorders; Chlordiazepoxide; Diagnosis

1974
Convulsions in children.
    The New England journal of medicine, 1968, Feb-08, Volume: 278, Issue:6

    Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Ethosuximide; Humans; Infant; M

1968
[Recent developments in psychopharmacology].
    Praxis, 1968, Feb-06, Volume: 57, Issue:5

    Topics: Antidepressive Agents; Barbiturates; Bipolar Disorder; Chlormethiazole; Depression; Diazepam; Electr

1968
[General review of the present therapy of epilepsy].
    Neuropsihijatrija, 1971, Volume: 19, Issue:1

    Topics: Anticonvulsants; Barbiturates; Chlordiazepoxide; Diazepam; Epilepsy; Humans; Hydantoins; Phenobarbit

1971

Trials

40 trials available for diazepam and Aura

ArticleYear
Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study.
    Pediatric neurology, 2022, Volume: 132

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Anticonvulsants; Child; Diazepam; Double-Blind

2022
Concomitant cannabidiol does not impact safety and effectiveness of diazepam nasal spray for seizure clusters: Post hoc analysis of a phase 3 safety study.
    Epilepsy & behavior : E&B, 2023, Volume: 144

    Topics: Anticonvulsants; Cannabidiol; Diazepam; Epilepsy; Humans; Nasal Sprays; Seizures; Treatment Outcome

2023
Safety of Diazepam Nasal Spray in Pediatric Patients With Developmental Epileptic Encephalopathies: Results From a Long-term Phase 3 Safety Study.
    Journal of child neurology, 2023, Volume: 38, Issue:6-7

    Topics: Anticonvulsants; Brain Diseases; Child; Diazepam; Epilepsy; Epilepsy, Generalized; Humans; Lennox Ga

2023
Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study.
    Epilepsia, 2020, Volume: 61, Issue:5

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Child; Diazepam; Epilepsy; Female; Humans; Male

2020
Safety and tolerability associated with chronic intermittent use of diazepam buccal film in adult, adolescent, and pediatric patients with epilepsy.
    Epilepsia, 2020, Volume: 61, Issue:11

    Topics: Administration, Buccal; Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Diazepam;

2020
Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study.
    Epilepsia, 2021, Volume: 62, Issue:6

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Diazepam; Dru

2021
Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study.
    Epilepsy & behavior : E&B, 2021, Volume: 120

    Topics: Administration, Intranasal; Diazepam; Epilepsy; Humans; Nasal Sprays; Seizures; Treatment Outcome

2021
Consistent safety and tolerability of Valtoco
    Epilepsia open, 2021, Volume: 6, Issue:3

    Topics: Administration, Intranasal; Diazepam; Epilepsy; Humans; Nasal Sprays; Seizures

2021
Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy.
    Epilepsia, 2021, Volume: 62, Issue:10

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Anticonvulsants; Brain Damage, Chronic; Child;

2021
A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures.
    Epilepsia, 2013, Volume: 54, Issue:11

    Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Caregivers; Child; Child, Preschool; Diazepam; Do

2013
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China.
    CNS drugs, 2016, Volume: 30, Issue:12

    Topics: Administration, Intravenous; Adult; Anticonvulsants; China; Diazepam; Epilepsy; Female; Humans; Male

2016
Acute administration of benzodiazepines as part of treatment strategies for epilepsy.
    CNS neuroscience & therapeutics, 2011, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Benzodiazepines; Clobazam; Diazepam; Dr

2011
Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy.
    Archives of pediatrics & adolescent medicine, 2010, Volume: 164, Issue:8

    Topics: Acute Disease; Administration, Intranasal; Administration, Rectal; Anticonvulsants; Child; Child, Pr

2010
Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study.
    European journal of neurology, 2011, Volume: 18, Issue:12

    Topics: Adult; Aged; Anticonvulsants; Cerebrovascular Disorders; Diazepam; Drug Resistance; Electroencephalo

2011
Intranasal midazolam vs rectal diazepam in acute childhood seizures.
    Pediatric neurology, 2006, Volume: 34, Issue:5

    Topics: Acute Disease; Administration, Intranasal; Anticonvulsants; Child; Child, Preschool; Diazepam; Epile

2006
A clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients.
    Journal of neurology, neurosurgery, and psychiatry, 1984, Volume: 47, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Clinical Trials as Topic; Diazepam

1984
Absorption of diazepam from the rectum and its effect on interictal spikes in the EEG.
    Epilepsia, 1982, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Diazepam; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Intestinal

1982
[Administration of a single oral high-dose of diazepam at bedtime as therapy for intractable seizures].
    No to hattatsu = Brain and development, 1995, Volume: 27, Issue:5

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Foll

1995
Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus.
    Developmental medicine and child neurology, 1995, Volume: 37, Issue:8

    Topics: Administration, Rectal; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Injections, Intravenou

1995
Bioavailability of benzodiazepines following rectal administration of diazepam in dogs.
    Journal of veterinary pharmacology and therapeutics, 1995, Volume: 18, Issue:1

    Topics: Administration, Rectal; Animals; Biological Availability; Cross-Over Studies; Diazepam; Dog Diseases

1995
Long term outcome of prophylaxis for febrile convulsions.
    Archives of disease in childhood, 1996, Volume: 74, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child Development; Cognition; Diazepam; Epilepsy; Follow-Up Stud

1996
Is ACTH a key to understanding anticonvulsant action?
    Developmental medicine and child neurology, 1998, Volume: 40, Issue:2

    Topics: Adenosine; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Binding Sites; Child; Chil

1998
A comparison of rectal diazepam gel and placebo for acute repetitive seizures.
    The New England journal of medicine, 1998, Jun-25, Volume: 338, Issue:26

    Topics: Acute Disease; Administration, Rectal; Adolescent; Adult; Child; Child, Preschool; Diazepam; Disease

1998
[Treatment for generalized seizures: the best of four methods].
    Presse medicale (Paris, France : 1983), 1999, Jan-23, Volume: 28, Issue:3

    Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Lorazepam; Phenobarbital; Phenytoin

1999
Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group.
    Pediatric neurology, 1999, Volume: 20, Issue:4

    Topics: Acute Disease; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepa

1999
An open-label study of repeated use of diazepam rectal gel (Diastat) for episodes of acute breakthrough seizures and clusters: safety, efficacy, and tolerance. North American Diastat Group.
    Epilepsia, 1999, Volume: 40, Issue:11

    Topics: Administration, Rectal; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Child, Prescho

1999
The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study.
    Journal of neurology, neurosurgery, and psychiatry, 1991, Volume: 54, Issue:4

    Topics: Adult; Anticonvulsants; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination

1991
Intermittent diazepam prophylaxis in febrile convulsions. Pros and cons.
    Acta neurologica Scandinavica. Supplementum, 1991, Volume: 135

    Topics: Behavior; Child, Preschool; Diazepam; Drug Administration Schedule; Epilepsy; Humans; Infant; Patien

1991
The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy.
    British journal of clinical pharmacology, 1986, Volume: 22, Issue:2

    Topics: Adult; Anticonvulsants; Clinical Trials as Topic; Diazepam; Double-Blind Method; Electroencephalogra

1986
Effective short-term diazepam prophylaxis in febrile convulsions.
    The Journal of pediatrics, 1985, Volume: 106, Issue:3

    Topics: Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Male; Patient Compliance; Random Alloc

1985
The use of diazepam in the control of status epilepticus.
    Electroencephalography and clinical neurophysiology, 1968, Volume: 24, Issue:4

    Topics: Clinical Trials as Topic; Diazepam; Electroencephalography; Epilepsy; Humans

1968
Comparative trial of diazepam and pheneturide in treatment of epilepsy.
    Lancet (London, England), 1969, Oct-25, Volume: 2, Issue:7626

    Topics: Age Factors; Diazepam; Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Male; Stress, Psychologica

1969
Treatment of hypsarrhythmia and infantile spasms with a librium analogue.
    Neurology, 1965, Volume: 15, Issue:12

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Child, Preschool; Chlordiazepoxide; Clinical Tr

1965
[An original psychotropic drug: sulpiride].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1969, Apr-20, Volume: 45, Issue:19

    Topics: Adult; Animals; Anxiety; Behavior; Clinical Trials as Topic; Cognition Disorders; Delirium; Depressi

1969
Studies with new drugs in the treatment of convulsive disorders.
    Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology, 1968, Volume: 1, Issue:3

    Topics: Adult; Aggression; Anticonvulsants; Anxiety; Carbamazepine; Clinical Trials as Topic; Diazepam; Dibe

1968
Effect of minor and major tranquilizers on somatosensory evoked potentials.
    Psychopharmacologia, 1972, Volume: 24, Issue:3

    Topics: Administration, Oral; Adult; Benzazepines; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topi

1972
[Clinico-experimental studies in the treatment of epilepsy with GABOB-diazepam].
    Minerva medica, 1973, May-23, Volume: 64, Issue:36

    Topics: Adolescent; Adult; Aminobutyrates; Child; Clinical Trials as Topic; Diazepam; Drug Combinations; Ele

1973
Clinical experience with clonazepam (Rivotril) in the treatment of epilepsies in infancy and childhood.
    Neuropadiatrie, 1973, Volume: 4, Issue:3

    Topics: Administration, Oral; Adolescent; Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlor

1973
Acute treatment of epileptic seizures with diazepamum (Valium).
    Acta neurologica Scandinavica, 1967, Volume: 43, Issue:S31

    Topics: Acute Disease; Adolescent; Adult; Aged; Aphasia; Clinical Trials as Topic; Diazepam; Epilepsy; Epile

1967
Treatment of status epilepticus with diazepam.
    Developmental medicine and child neurology, 1966, Volume: 8, Issue:6

    Topics: Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Electroencephalography; Epilepsy; Femal

1966

Other Studies

434 other studies available for diazepam and Aura

ArticleYear
Synthesis of gem-difluoro-avermectin derivatives: potent anthelmintic and anticonvulsant agents.
    Bioorganic & medicinal chemistry letters, 1998, Dec-15, Volume: 8, Issue:24

    Topics: Animals; Anthelmintics; Anticonvulsants; Epilepsy; Ivermectin; Mice; Molecular Structure

1998
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
    Bioorganic & medicinal chemistry, 2016, Apr-15, Volume: 24, Issue:8

    Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru

2016
Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus.
    Brain : a journal of neurology, 2022, 04-29, Volume: 145, Issue:3

    Topics: Animals; Diazepam; Epilepsy; Hippocampus; Humans; Lysine; Mice; Mice, Inbred C57BL; Rats; Status Epi

2022
Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio).
    Neurochemical research, 2022, Volume: 47, Issue:11

    Topics: Animals; Anticonvulsants; Caspase 3; Diazepam; Epilepsy; Interleukin-1beta; Neuroprotective Agents;

2022
Use of new intranasal benzodiazepines at a typical adult epilepsy center.
    Epilepsy & behavior : E&B, 2022, Volume: 134

    Topics: Administration, Intranasal; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Epilepsy, G

2022
Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters.
    Epilepsia, 2022, Volume: 63, Issue:10

    Topics: Administration, Intranasal; Adult; Anticonvulsants; Brain Damage, Chronic; Diazepam; Epilepsy; Epile

2022
Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures.
    Epilepsy research, 2022, Volume: 186

    Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diazepam; Disease Models, Animal; Epilepsy; Exercise;

2022
Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.
    Life sciences, 2023, Jan-15, Volume: 313

    Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Cytokines; Diazepam; Disease Models, Animal; Epilep

2023
Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model.
    Scientific reports, 2023, 01-05, Volume: 13, Issue:1

    Topics: Animals; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Magnetic Fields; Piloca

2023
Epileptic Status in a PEDiatric cohort (ESPED) requiring intensive care treatment: A multicenter, national, two-year prospective surveillance study.
    Epilepsia open, 2023, Volume: 8, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Critical Care; Diazepam; Epilepsy; Female; Humans; Male; Midazol

2023
CRISPR-Based KCC2 Upregulation Attenuates Drug-Resistant Seizure in Mouse Models of Epilepsy.
    Annals of neurology, 2023, Volume: 94, Issue:1

    Topics: Animals; Calcium; Diazepam; Epilepsy; Hippocampus; Kainic Acid; Mice; Pharmaceutical Preparations; S

2023
Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy?
    Epilepsia, 2023, Volume: 64, Issue:8

    Topics: Animals; Biomarkers; Diazepam; Epilepsy; Intermediate Filaments; Kainic Acid; Ketamine; Mice; Neurof

2023
Sublingual lorazepam as rescue therapy for seizure emergencies in adults.
    Epilepsy & behavior : E&B, 2023, Volume: 145

    Topics: Adult; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Lorazepam; Retrospective Studies; S

2023
Utilization of Antiseizure Medications in Women of Childbearing Age With Epilepsy and Nonepilepsy Indications: A Retrospective Cohort Study.
    Neurology, 2023, 09-05, Volume: 101, Issue:10

    Topics: Anticonvulsants; Clonazepam; Diazepam; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Lorazepam;

2023
Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus.
    Brain : a journal of neurology, 2019, 11-01, Volume: 142, Issue:11

    Topics: Animals; Anticonvulsants; Benzodiazepines; Child, Preschool; Diazepam; Drug Resistance; Drug Resista

2019
Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy.
    Molecular brain, 2019, 11-10, Volume: 12, Issue:1

    Topics: Amino Acid Sequence; Child; Chloride Channels; Diazepam; Electroencephalography; Epilepsy; Female; G

2019
Diagnostic evaluation and management of seizures and status epilepticus in children with known epilepsy or new-onset seizures: A retrospective and comparative analysis.
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2020, Volume: 27, Issue:2

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clonazepam; Diazepam; Epilepsy; Female; Hospit

2020
A novel de novo variant of GABRA1 causes increased sensitivity for GABA in vitro.
    Scientific reports, 2020, 02-11, Volume: 10, Issue:1

    Topics: Child; Developmental Disabilities; Diazepam; Epilepsy; GABA Modulators; gamma-Aminobutyric Acid; HEK

2020
Intranasal diazepam (Valtoco) and midazolam (Nayzilam) for seizure clusters.
    The Medical letter on drugs and therapeutics, 2020, Apr-20, Volume: 62, Issue:1596

    Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Epilepsy; Humans; Midazolam; Seizures

2020
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
    Journal of ethnopharmacology, 2021, May-23, Volume: 272

    Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mi

2021
Intra-hippocampal microinjection of oxytocin produced antiepileptic effect on the pentylenetetrazol-induced epilepsy in rats.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:4

    Topics: Animals; Anticonvulsants; Diazepam; Epilepsy; Flumazenil; Hippocampus; Male; Microinjections; Oxytoc

2017
Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice.
    Nutritional neuroscience, 2019, Volume: 22, Issue:3

    Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilep

2019
Healthcare Utilization Characteristics for Intranasal Midazolam Versus Rectal Diazepam.
    Journal of child neurology, 2018, Volume: 33, Issue:2

    Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Adult; Ambulatory Care; Anticonvulsa

2018
Effect of rescue medication on seizure duration in non-institutionalized children with epilepsy.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2018, Volume: 22, Issue:1

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Male; Mida

2018
Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders.
    Bulletin of experimental biology and medicine, 2018, Volume: 165, Issue:2

    Topics: Administration, Inhalation; Albuterol; Animals; Atropine; Bronchodilator Agents; Convulsants; Diazep

2018
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
    The Pan African medical journal, 2013, Volume: 14

    Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Human

2013
The cost effectiveness of licensed oromucosal midazolam (Buccolam(®)) for the treatment of children experiencing acute epileptic seizures: an approach when trial evidence is limited.
    Paediatric drugs, 2013, Volume: 15, Issue:2

    Topics: Acute Disease; Administration, Buccal; Administration, Rectal; Child; Cost-Benefit Analysis; Decisio

2013
GABAergic tonic inhibition is regulated by developmental age and epilepsy in the dentate gyrus.
    Neuroreport, 2013, Jul-10, Volume: 24, Issue:10

    Topics: Aging; Animals; Anticonvulsants; Data Interpretation, Statistical; Dentate Gyrus; Diazepam; Electrop

2013
Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep.
    Pediatric neurology, 2013, Volume: 49, Issue:3

    Topics: Adolescent; Anticonvulsants; Brain Waves; Child; Child, Preschool; Diazepam; Dose-Response Relations

2013
Feasibility study of a caregiver seizure alert system in canine epilepsy.
    Epilepsy research, 2013, Volume: 106, Issue:3

    Topics: Algorithms; Animals; Anticonvulsants; Caregivers; Chromatography, High Pressure Liquid; Clinical Ala

2013
A patient with progressive cognitive decline and periodic abnormal waves in EEG: PLEDs of neurosyphilis or PSDs of Creutzfeldt-Jakob disease?
    Clinical EEG and neuroscience, 2014, Volume: 45, Issue:3

    Topics: Atrophy; China; Coma; Creutzfeldt-Jakob Syndrome; Dementia; Diagnosis, Differential; Diazepam; Diffu

2014
Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Electroencephalograp

2013
Episodic epileptic verbal auditory agnosia in Landau Kleffner syndrome treated with combination diazepam and corticosteroids.
    Journal of child neurology, 2014, Volume: 29, Issue:10

    Topics: Adrenal Cortex Hormones; Agnosia; Anticonvulsants; Brain; Child; Child, Preschool; Diazepam; Electro

2014
Prognostic factors for acute encephalopathy with bright tree appearance.
    Brain & development, 2015, Volume: 37, Issue:2

    Topics: Acute Disease; Anti-Anxiety Agents; Brain; Brain Diseases; Child; Child, Preschool; Creatinine; Diaz

2015
[Electrophysiology of intractable childhood epilepsy].
    No to hattatsu = Brain and development, 2014, Volume: 46, Issue:3

    Topics: Brain; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid;

2014
Effects of intracortical microinjection of vitamin B12 on penicillin-induced epileptiform activity in rats.
    Acta neurobiologiae experimentalis, 2015, Volume: 75, Issue:2

    Topics: Animals; Anticonvulsants; Benzodiazepines; Diazepam; Electroencephalography; Epilepsy; Male; Microin

2015
Alterations in hippocampal myelin and oligodendrocyte precursor cells during epileptogenesis.
    Brain research, 2015, Nov-19, Volume: 1627

    Topics: Animals; Cell Differentiation; Diazepam; Disease Models, Animal; Epilepsy; Hippocampus; Muscarinic A

2015
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
    Epilepsy & behavior : E&B, 2016, Volume: 57, Issue:Pt A

    Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni

2016
Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model.
    Epilepsy research, 2016, Volume: 127

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cerebral Cortex; Diazepam; Diclof

2016
Response to diazepam in children with malaria-induced seizures.
    Epilepsy research, 2008, Volume: 82, Issue:2-3

    Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Female; Histidine; Humans; Infant; Inj

2008
Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis.
    Amino acids, 2010, Volume: 38, Issue:1

    Topics: Amygdala; Animals; Diazepam; Epilepsy; Hippocampus; Male; Nerve Degeneration; Random Allocation; Rat

2010
Validation of anticonvulsant and sedative activity of six medicinal plants.
    Epilepsy & behavior : E&B, 2009, Volume: 14, Issue:3

    Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electroshock; Epi

2009
Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy.
    Brain research bulletin, 2009, Jun-30, Volume: 79, Issue:5

    Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Cell Death; Diazepam; Electroencephalogr

2009
Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways.
    Journal of ethnopharmacology, 2009, Jun-22, Volume: 123, Issue:2

    Topics: Animals; Anticonvulsants; Cyproheptadine; Diazepam; Disease Models, Animal; Dose-Response Relationsh

2009
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.
    Neurobiology of disease, 2009, Volume: 36, Issue:1

    Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety

2009
Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide.
    Epilepsia, 2010, Volume: 51, Issue:2

    Topics: Acetamides; Adult; Anticonvulsants; Diazepam; Drug Resistance; Drug Therapy, Combination; Epilepsy;

2010
Guidelines for diagnosis and management of childhood epilepsy.
    Indian pediatrics, 2009, Volume: 46, Issue:8

    Topics: Algorithms; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Hu

2009
Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome.
    Annals of neurology, 2009, Volume: 66, Issue:2

    Topics: Action Potentials; Bumetanide; Cerebral Cortex; Diazepam; Epilepsy; Excitatory Amino Acid Antagonist

2009
A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations.
    Epilepsia, 2010, Volume: 51, Issue:3

    Topics: Acute Disease; Administration, Intranasal; Administration, Rectal; Benzodiazepines; Diazepam; Drug A

2010
Qualitative analysis of hippocampal plastic changes in rats with epilepsy supplemented with oral omega-3 fatty acids.
    Epilepsy & behavior : E&B, 2010, Volume: 17, Issue:1

    Topics: Administration, Oral; Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine

2010
Anticonvulsant activity of DNS II fraction in the acute seizure models.
    Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3

    Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre

2010
Migraine triggered by epileptic discharges in a Rasmussen's encephalitis patient after surgery.
    Brain & development, 2011, Volume: 33, Issue:7

    Topics: Adolescent; Anticonvulsants; Child; Diazepam; Electroencephalography; Encephalitis; Epilepsy; Humans

2011
Treatment gap for people living with epilepsy in Madagascar.
    Tropical doctor, 2011, Volume: 41, Issue:1

    Topics: Anticonvulsants; Barbiturates; Delivery of Health Care; Developing Countries; Diazepam; Drug Therapy

2011
Rectal diazepam solution is as good as rectal administration of intravenous diazepam in the first-aid cessation of seizures in children with intractable epilepsy.
    Pediatrics and neonatology, 2011, Volume: 52, Issue:1

    Topics: Administration, Rectal; Adolescent; Anticonvulsants; Chi-Square Distribution; Child; Child, Preschoo

2011
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
    Life sciences, 2011, Aug-15, Volume: 89, Issue:7-8

    Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Di

2011
A cell-free extract from human adipose stem cells protects mice against epilepsy.
    Epilepsia, 2011, Volume: 52, Issue:9

    Topics: Adipose Tissue; Animals; Animals, Newborn; Anticonvulsants; Blood-Brain Barrier; Cell Extracts; Cell

2011
Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 340, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Animals; Biocatalysis; Diazepam; Electroencephalography; Epile

2012
Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons.
    Nature neuroscience, 2011, Dec-11, Volume: 15, Issue:2

    Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium-Calmodulin-Dependent Protein Kinase Type 2;

2011
A mouse kindling model of perimenstrual catamenial epilepsy.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 341, Issue:3

    Topics: 5-alpha Reductase Inhibitors; Animals; Diazepam; Disease Models, Animal; Epilepsy; Female; Finasteri

2012
Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.
    Epilepsia, 2012, Volume: 53, Issue:5

    Topics: Animals; Anticonvulsants; Benzoxazines; Brain; Brain Mapping; Diazepam; Disease Models, Animal; Epil

2012
Central effect of crocin on penicillin-induced epileptiform activity in rats.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:1

    Topics: Animals; Anticonvulsants; Brain; Carotenoids; Diazepam; Disease Models, Animal; Dose-Response Relati

2012
Evaluation of the sedative and anticonvulsant properties of three Cameroonian plants.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2011, Volume: 8, Issue:5 Suppl

    Topics: Administration, Oral; Analysis of Variance; Animals; Anticonvulsants; Cameroon; Diazepam; Dose-Respo

2011
Primary afterdischarge in organotypic hippocampal slice cultures: effects of standard antiepileptic drugs.
    Epilepsia, 2012, Volume: 53, Issue:11

    Topics: Action Potentials; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Epilepsy; H

2012
Synthesis and pharmacological investigation of 2-(4-dimethylaminophenyl)-3,5-disubstituted thiazolidin-4-ones as anticonvulsants.
    Archiv der Pharmazie, 2012, Volume: 345, Issue:10

    Topics: Acetamides; Animals; Anticonvulsants; Benzamides; Diazepam; Disease Models, Animal; Epilepsy; Male;

2012
Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:9

    Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship,

2012
Vagal nerve stimulation in New Zealand: improvement of seizure control following the implantation of a vagal nerve stimulator.
    The New Zealand medical journal, 2012, Sep-07, Volume: 125, Issue:1361

    Topics: Adult; Anticonvulsants; Diazepam; Epilepsy; Humans; Male; New Zealand; Vagus Nerve Stimulation

2012
Effects of intravenous diazepam on high-frequency oscillations in EEGs with CSWS.
    Brain & development, 2013, Volume: 35, Issue:6

    Topics: Administration, Intravenous; Anticonvulsants; Brain Waves; Child; Child, Preschool; Diazepam; Electr

2013
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
    Neuromolecular medicine, 2013, Volume: 15, Issue:1

    Topics: Animals; Anticonvulsants; Biomarkers; Cell Hypoxia; Cerebral Cortex; Convulsants; Diazepam; Disease

2013
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
    Pharmacology, biochemistry, and behavior, 2013, Volume: 104

    Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo

2013
Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Animals; Behavior, Animal; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relat

2013
Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse.
    Journal of neuroscience research, 2002, Sep-01, Volume: 69, Issue:5

    Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Death; Diazepam; Disease Models, Animal; Electr

2002
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Nov-12, Volume: 99, Issue:23

    Topics: Amino Acid Substitution; Animals; Anti-Anxiety Agents; Cell Line; Diazepam; Epilepsy; Flunitrazepam;

2002
[Epileptic Münchausen syndrome by idiosyncratic of effect antiepileptic drugs].
    Revue neurologique, 2003, Volume: 159, Issue:3

    Topics: Adult; Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Female; Headache; Humans; Muncha

2003
Phenytoin-diazepam interaction.
    The Annals of pharmacotherapy, 2003, Volume: 37, Issue:5

    Topics: Adult; Anticonvulsants; Diazepam; Drug Interactions; Epilepsy; Humans; Male; Phenytoin

2003
Educating lay carers of people with learning disability in epilepsy awareness and in the use of rectal diazepam: a suggested teaching protocol for use by healthcare personnel.
    Health bulletin, 1999, Volume: 57, Issue:3

    Topics: Administration, Rectal; Anticonvulsants; Caregivers; Diazepam; Epilepsy; Home Health Aides; Humans;

1999
[CLINICAL EVALUATION OF BENZODIAZEPINONE].
    El Dia medico, 1963, Dec-23, Volume: 35

    Topics: Alcoholism; Diazepam; Epilepsy; Humans; Mental Disorders; Tranquilizing Agents

1963
DIAZEPAM: ITS ROLE IN A PRISON SETTING.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Adolescent; Diazepam; Epilepsy; Geriatrics; Humans; Mental Disorders; Prisons; Psychotic Disorders;

1964
[CHANGES IN EPILEPTIC ACTIVITY INDUCED BY LOCAL APPLICATION OF STRYCHNINE IN ANIMALS TREATED WITH DERIVATIVES OF BENZODIAZEPINE].
    Bollettino della Societa italiana di biologia sperimentale, 1963, Dec-31, Volume: 39

    Topics: Benzodiazepines; Chlordiazepoxide; Diazepam; Epilepsy; Pharmacology; Rabbits; Research; Strychnine;

1963
COMPARATIVE STUDY OF CHLORDIAZEPOXIDE AND DIAZEPAM.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Cerebral Palsy; Chlordiazepoxide; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Int

1964
[CLINICAL STUDY OF VALIUM IN 50 "EPILEPTIC" PATIENTS].
    Medicina, 1964, Mar-25, Volume: 44

    Topics: Adolescent; Biomedical Research; Child; Diazepam; Electroencephalography; Epilepsy; Mexico; Pharmaco

1964
[CLINICAL EXPERIENCES WITH VALIUM ROCHE, A NEW BENZODIAZEPINE DERIVATIVE].
    Schweizerische medizinische Wochenschrift, 1964, Mar-21, Volume: 94

    Topics: Antisocial Personality Disorder; Anxiety; Anxiety Disorders; Autonomic Nervous System Diseases; Benz

1964
DIAZEPAM (VALIUM) IN MYOCLONIC SEIZURES. FAVORABLE RESPONSE DURING INFANCY AND CHILDHOOD.
    American journal of diseases of children (1960), 1965, Volume: 109

    Topics: Anticonvulsants; Child; Diazepam; Drug Therapy; Electroencephalography; Epilepsies, Myoclonic; Epile

1965
THE LONG-TERM USE OF VALIUM.
    The American journal of psychiatry, 1965, Volume: 121

    Topics: Depression; Depressive Disorder; Diazepam; Drug Therapy; Epilepsy; Intellectual Disability

1965
TOXIC PSYCHOSIS WITH TRANSIENT DYSMNESTIC SYNDROME FOLLOWING WITHDRAWAL FROM VALIUM.
    The American journal of psychiatry, 1965, Volume: 121

    Topics: Chlorpromazine; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; Hallucinations; Humans; Memory; Psychose

1965
LONG TERM CLINICAL TRIAL WITH DIAZEPAM ON ADULT MENTALLY RETARDED PERSONS.
    Diseases of the nervous system, 1965, Volume: 26

    Topics: Adult; Brain; Brain Damage, Chronic; Diazepam; Drug Therapy; Epilepsy; Epilepsy, Absence; Epilepsy,

1965
TREATMENT OF STATUS EPILEPTICUS WITH DIAZEPAM (VALIUM).
    Epilepsia, 1965, Volume: 6

    Topics: Adolescent; Barbiturates; Child; Diazepam; Drug Therapy; Electrocardiography; Electroencephalography

1965
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
    Progress in neuro-psychopharmacology & biological psychiatry, 2004, Volume: 28, Issue:1

    Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-R

2004
Treatment and outcome in patients with febrile convulsion associated with epileptiform discharges on electroencephalography.
    Brain & development, 2004, Volume: 26, Issue:4

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Drug Administration Schedule; Electroencephalography; E

2004
Suppression of fully kindled seizure and retardation of kindling acquisition by YM928 in the rat kindling model of epilepsy.
    European journal of pharmacology, 2004, Jun-28, Volume: 494, Issue:2-3

    Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Electrodes, Implanted; Electro

2004
[A case of advanced rhabdomyosarcoma of the spermatic cord who occurred epilepsy-like symptoms, but was completely responded to chemotherapy].
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 2004, Volume: 95, Issue:5

    Topics: Adult; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Diazepam; Epileps

2004
Acute effect of an extract of Ambrosia paniculata (Willd.) O. E. Schultz (mugwort) in several models of experimental epilepsy.
    Epilepsy & behavior : E&B, 2004, Volume: 5, Issue:6

    Topics: Ambrosia; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Diazepa

2004
Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
    Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:4

    Topics: Animals; Anticonvulsants; Benzoquinones; Convulsants; Diazepam; Epilepsy; Flumazenil; Injections, In

2005
Respiratory adverse events associated with diazepam rectal gel.
    Neurology, 2005, May-24, Volume: 64, Issue:10

    Topics: Administration, Rectal; Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Interactions

2005
[Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy].
    Nederlands tijdschrift voor geneeskunde, 2005, Jun-18, Volume: 149, Issue:25

    Topics: Adult; Anticonvulsants; Cesarean Section; Clonazepam; Diazepam; Epilepsy; Epilepsy, Generalized; Epi

2005
Rectal diazepam gel in the home management of seizures in children.
    Pediatric neurology, 2005, Volume: 33, Issue:3

    Topics: Administration, Rectal; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Service, Hospi

2005
Ictal monoparesis associated with lesions in the primary somatosensory area.
    Neurology, 2005, Nov-08, Volume: 65, Issue:9

    Topics: Adult; Arm; Brain Damage, Chronic; Brain Neoplasms; Cerebral Angiography; Cerebral Veins; Diazepam;

2005
Spike-wave stupor in a patient with metabolic encephalopathy.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2007, Volume: 14, Issue:2

    Topics: Ammonia; Anticonvulsants; Brain Diseases, Metabolic; Coma; Diagnosis, Differential; Diazepam; Electr

2007
Anticonvulsant properties of hypothermia in experimental status epilepticus.
    Neurobiology of disease, 2006, Volume: 23, Issue:3

    Topics: Animals; Anticonvulsants; Body Temperature; Brain; Cold Temperature; Dentate Gyrus; Diazepam; Diseas

2006
Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse.
    Annals of nuclear medicine, 2006, Volume: 20, Issue:8

    Topics: Animals; Anticonvulsants; Autoradiography; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumaz

2006
[Epilepsy: which therapy in acute care?].
    Deutsche medizinische Wochenschrift (1946), 2006, Dec-08, Volume: 131, Issue:49

    Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Clobazam; Clonazepam; Diazepam; Epilepsy; Humans; L

2006
Audit of the use of buccal diazepam at a residential centre for children with epilepsy.
    Developmental medicine and child neurology, 2007, Volume: 49, Issue:2

    Topics: Administration, Buccal; Adolescent; Adult; Anticonvulsants; Diazepam; Epilepsy; Female; Hospitals, C

2007
Sleep-related epilepsy in the A/J mouse.
    Sleep, 2007, Volume: 30, Issue:2

    Topics: Alleles; Animals; Anticonvulsants; Chromosomes, Mammalian; Diazepam; Disease Models, Animal; Electro

2007
Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs.
    Epilepsia, 2007, Volume: 48, Issue:3

    Topics: Anticonvulsants; Astrocytes; Blood-Brain Barrier; Brain; Cells, Cultured; Coculture Techniques; Diaz

2007
Early diffusion-weighted MRI predicts regional neuronal damage in generalized status epilepticus in rats treated with diazepam.
    Neuroscience letters, 2007, May-07, Volume: 417, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Brain Damage, Chronic; Convulsants; Diazepam; Diffusion; Diffusion

2007
Loss of input from the mossy cells blocks maturation of newly generated granule cells.
    Hippocampus, 2007, Volume: 17, Issue:7

    Topics: Animals; Anticonvulsants; Biomarkers; Bromodeoxyuridine; Calbindin 2; Cell Differentiation; Cell Pro

2007
School nurses' experience with administration of rectal diazepam gel for seizures.
    The Journal of school nursing : the official publication of the National Association of School Nurses, 2007, Volume: 23, Issue:3

    Topics: Administration, Rectal; Anticonvulsants; Child; Diazepam; Emergencies; Epilepsy; Gels; Health Care S

2007
AMPA receptor activation reduces epileptiform activity in the rat neocortex.
    Brain research, 2007, Jul-16, Volume: 1158

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim

2007
Acceptance of the use of diazepam rectal gel in school and day care settings.
    Journal of child neurology, 2007, Volume: 22, Issue:9

    Topics: Administration, Rectal; Adolescent; Anticonvulsants; Child; Child Day Care Centers; Child, Preschool

2007
Treatment of refractory seizures due to a benign mass present in the corpus callosum with an ion magnetic inductor: case report.
    Brain tumor pathology, 2005, Volume: 22, Issue:2

    Topics: Adult; Agenesis of Corpus Callosum; Anticonvulsants; Colchicine; Combined Modality Therapy; Corpus C

2005
Funny turns in an elderly man.
    The West Indian medical journal, 2007, Volume: 56, Issue:4

    Topics: Age Factors; Aged; Anticonvulsants; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Male; Recur

2007
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
    Journal of neural transmission (Vienna, Austria : 1996), 2008, Volume: 115, Issue:6

    Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Re

2008
[Postictal paranoid-hallucinatory psychosis in cryptogenic epilepsy].
    Psychiatrische Praxis, 2007, Volume: 34, Issue:5

    Topics: Acute Disease; Adult; Anticonvulsants; Cooperative Behavior; Delusions; Diazepam; Epilepsy; Epilepsy

2007
[Progressive myoclonus epilepsy with Lafora bodies. Clinical and polygraphic study. Anatomical ultrastructural verification].
    Revue neurologique, 1967, Volume: 116, Issue:3

    Topics: Adolescent; Brain; Cytoplasmic Granules; Diazepam; Electrocardiography; Electroencephalography; Elec

1967
Pharmacokinetics of benzodiazepines and psychostimulants in children.
    Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:4

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Attention Deficit Disorder with Hyperactivity; Biotransforma

1983
Pharmacology of methyl- and propyl-beta-carbolines in a hereditary model of epilepsy.
    Neuropharmacology, 1984, Volume: 23, Issue:9

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Chickens; Convulsants; Diazepam; Epilepsy

1984
Antiepileptic effect and serum levels of clorazepate on children with refractory seizures.
    Brain & development, 1984, Volume: 6, Issue:6

    Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Clorazepate Dipota

1984
Correlations between EEG changes induced by diazepam and the localization of epileptic spikes and seizures.
    Electroencephalography and clinical neurophysiology, 1982, Volume: 54, Issue:6

    Topics: Adult; Brain; Diazepam; Electroencephalography; Epilepsy; Evoked Potentials; Humans

1982
[Antiepileptic effects of synthetic pharmacologic agents and vitamin preparations used in combination].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1984, Volume: 84, Issue:6

    Topics: Animals; Anticonvulsants; Crosses, Genetic; Diazepam; Drug Therapy, Combination; Epilepsy; Mice; Mic

1984
Brain benzodiazepine receptors and their rapid changes after seizures in the Mongolian gerbil.
    Japanese journal of pharmacology, 1980, Volume: 30, Issue:6

    Topics: Animals; Binding Sites; Brain; Diazepam; Disease Models, Animal; Epilepsy; Gerbillinae; Receptors, D

1980
Rectal diazepam: a clinical and EEG study after a single dose in children.
    Epilepsia, 1983, Volume: 24, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsies, Myoclonic; Epilep

1983
Active metabolites in antiepileptic therapy. Reflections on a pharmacological joker.
    Acta neurologica Scandinavica. Supplementum, 1983, Volume: 94

    Topics: Anticonvulsants; Biotransformation; Carbamazepine; Diazepam; Epilepsy; Humans; Kinetics; Primidone;

1983
Maprotiline hydrochloride associated with a clinical state of catatonic stupor and epileptic encephalogram.
    Journal of clinical psychopharmacology, 1984, Volume: 4, Issue:4

    Topics: Anthracenes; Catatonia; Depressive Disorder; Diazepam; Drug Therapy, Combination; Electroencephalogr

1984
Case report: psychomotor status-like episodes under haloperidol treatment.
    The British journal of psychiatry : the journal of mental science, 1984, Volume: 145

    Topics: Adult; Diazepam; Epilepsy; Haloperidol; Humans; Male; Schizophrenia

1984
Prophylaxis and febrile convulsions.
    Archives of disease in childhood, 1981, Volume: 56, Issue:2

    Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Se

1981
Serum protein binding of diazepam and its displacement by valproic acid in vitro.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:4

    Topics: Binding, Competitive; Diazepam; Epilepsy; Humans; In Vitro Techniques; Serum Albumin; Valproic Acid

1981
Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration.
    British journal of clinical pharmacology, 1981, Volume: 12, Issue:6

    Topics: Adult; Diazepam; Epilepsy; Half-Life; Humans; Injections, Intravenous; Male; Nordazepam

1981
["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis].
    Fortschritte der Medizin, 1982, Jun-24, Volume: 100, Issue:24

    Topics: Child, Preschool; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Parents; Phenobarbita

1982
A study of the action of anticonvulsant drugs on an experimental model of epilepsy.
    Acta physiologica latino americana, 1980, Volume: 30, Issue:4

    Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Electric Stimulation; Epi

1980
Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 1980, Volume: 77, Issue:5

    Topics: Amygdala; Animals; Benzodiazepines; Cerebral Cortex; Diazepam; Disease Models, Animal; Electroshock;

1980
Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients.
    British journal of clinical pharmacology, 1982, Volume: 13, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Diazepam; Epilepsy; Female; Humans

1982
Rectal absorption of diazepam in epileptic children.
    Archives of disease in childhood, 1982, Volume: 57, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Intestinal Absorption; Rect

1982
Some practical hints and management of convulsions occurring in infancy and children.
    Tropical doctor, 1981, Volume: 11, Issue:1

    Topics: Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Fever; Humans; Infant; Infant, Newborn; Seizu

1981
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled cortical seizures.
    Neuropharmacology, 1981, Volume: 20, Issue:11

    Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Disease Models, Animal; Epilepsy; Mal

1981
[Systems relations in neuropathology and psychiatry (various problems in treatment)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1981, Volume: 81, Issue:8

    Topics: Central Nervous System; Chorea; Diazepam; Epilepsy; Humans; Mental Disorders; Nervous System Disease

1981
Wall-coated open tubular column coupled with nitrogen-selective detector for routine GLC determination of diazepam, meprobamate, phenylbutazone, and thioridazine in serum.
    Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:7

    Topics: Adolescent; Adult; Child; Chromatography, Gas; Diazepam; Epilepsy; Female; Humans; Male; Meprobamate

1980
[Paroxysmal dyskinesia during treatment with diphenylhydantoin].
    Revue neurologique, 1980, Volume: 136, Issue:1

    Topics: Adult; Brain Diseases; Child; Child, Preschool; Diazepam; Dyskinesia, Drug-Induced; Epilepsy; Female

1980
Febrile seizures: long-term management of children with fever-associated seizures. Summary of an NIH consensus statement.
    British medical journal, 1980, Jul-26, Volume: 281, Issue:6235

    Topics: Child, Preschool; Diazepam; Epilepsy; Fever; Humans; Infant; Phenobarbital; Risk; Seizures; Seizures

1980
Dynamic study of the acoustico-facial reflex by impedance measurement.
    Archives of oto-rhino-laryngology, 1980, Volume: 228, Issue:2

    Topics: Acoustic Impedance Tests; Aging; Auditory Fatigue; Diazepam; Epilepsy; Humans; Hyperacusis; Loudness

1980
Extending the indications of registered drugs: rectal diazepam in epilepsy.
    The Medical journal of Australia, 1995, Oct-16, Volume: 163, Issue:8

    Topics: Administration, Rectal; Anticonvulsants; Australia; Diazepam; Drug Approval; Epilepsy; Humans

1995
Airline policy relating to passengers with epilepsy.
    Archives of neurology, 1995, Volume: 52, Issue:12

    Topics: Aerospace Medicine; Diazepam; Epilepsy; Humans; Organizational Policy; Surveys and Questionnaires

1995
Position statement on the use of rectal diazepam in epilepsy. Epilepsy Society of Australia, the Child Neurology Study Group, the Australian Association of Neurologists, and the National Epilepsy Association of Australia.
    The Medical journal of Australia, 1995, Sep-04, Volume: 163, Issue:5

    Topics: Administration, Rectal; Anticonvulsants; Australia; Child; Diazepam; Emergencies; Epilepsy; Home Nur

1995
Oral flumazenil in the treatment of epilepsy.
    The Annals of pharmacotherapy, 1995, Volume: 29, Issue:5

    Topics: Administration, Oral; Clinical Trials as Topic; Diazepam; Drug Therapy, Combination; Epilepsy; Epile

1995
Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats.
    Experimental brain research, 1995, Volume: 102, Issue:3

    Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy; Hippocampus; Histocytochemistr

1995
Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4

    Topics: Animals; Anti-Anxiety Agents; Diazepam; Electroencephalography; Epilepsy; Eye Movements; Heart Rate;

1994
Kainate-induced apoptotic cell death in hippocampal neurons.
    Neuroscience, 1994, Volume: 63, Issue:1

    Topics: Animals; Apoptosis; Cell Nucleus; Diazepam; DNA; Electrophoresis, Polyacrylamide Gel; Epilepsy; Hipp

1994
Rectal administration of diazepam.
    Journal of child neurology, 1994, Volume: 9, Issue:3

    Topics: Administration, Rectal; Cardiopulmonary Resuscitation; Diazepam; Epilepsy; Humans; Respiratory Insuf

1994
Epilepsy treatment in The Netherlands. Comparison of matched groups of two medical centres.
    Acta neurologica Scandinavica, 1994, Volume: 89, Issue:6

    Topics: Adolescent; Adult; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Female; gamma-Aminobutyric Acid;

1994
[Diazepam-induced EEG changes as a predictor of the outcome of epilepsy].
    Zhonghua nei ke za zhi, 1993, Volume: 32, Issue:12

    Topics: Clonazepam; Diazepam; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Male; Pro

1993
Status epilepticus: management and outcome of 107 episodes.
    Seizure, 1994, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Aged; Chlormethiazole; Clinical Protocols; Diazepam; Epilepsy; Female; Humans; In

1994
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
    Epilepsy research, 1993, Volume: 15, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Var

1993
The need for guidelines on the use of rectal diazepam.
    Seizure, 1993, Volume: 2, Issue:1

    Topics: Administration, Rectal; Adult; Child; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; First Aid; Humans;

1993
Diazepam to prevent febrile seizures.
    The New England journal of medicine, 1993, Dec-30, Volume: 329, Issue:27

    Topics: Child; Diazepam; Electroencephalography; Epilepsy; Humans; Seizures, Febrile

1993
Neurophysiologic and clinical correlations of epileptic nystagmus.
    Neurology, 1993, Volume: 43, Issue:12

    Topics: Adult; Aged; Child; Consciousness; Diazepam; Electroencephalography; Epilepsy; Eye Movements; Female

1993
[Drug therapy and its problems in epilepsy].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 1993, Volume: 12, Issue:11

    Topics: Clonazepam; Diazepam; Emergencies; Epilepsy; Humans

1993
The prognostic significance of diazepam-induced EEG changes in epilepsy: a follow-up study.
    Clinical EEG (electroencephalography), 1993, Volume: 24, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Beta Rhythm; Child; Clonazepam; Diazepam; Drug Therapy, Co

1993
[Five cases of paroxysmal sleep disturbances].
    No to hattatsu = Brain and development, 1993, Volume: 25, Issue:3

    Topics: Carbamazepine; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalography; E

1993
Modifications of diazepam binding inhibitor and peripheral benzodiazepine receptors in the lymphocytes of epileptic patients.
    Italian journal of neurological sciences, 1996, Volume: 17, Issue:2

    Topics: Adolescent; Carbamazepine; Child; Diazepam; Epilepsy; Female; Humans; Lymphocytes; Male; Receptors,

1996
Early clinical and EEG features of infantile spasms in Down syndrome.
    Epilepsia, 1996, Volume: 37, Issue:10

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Comorbidity; Diazepam; Down Syndrome; Elect

1996
Tolerance to anticonvulsant effects of some benzodiazepines in genetically epilepsy prone rats.
    Pharmacology, biochemistry, and behavior, 1996, Volume: 55, Issue:1

    Topics: Acoustic Stimulation; Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiaz

1996
Effects of diazepam on fentanyl-induced epileptoid EEG activity and increase of multineuronal firing in limbic and mesencephalic brain structures.
    Archives of medical research, 1996,Winter, Volume: 27, Issue:4

    Topics: Animals; Cats; Diazepam; Electroencephalography; Epilepsy; Fentanyl; Limbic System; Male; Mesencepha

1996
Diazepam--its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss.
    Pharmacological research, 1997, Volume: 35, Issue:1

    Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cell Count; Convulsants; Diazepam;

1997
Blockade of spreading depression in chronic epileptic rats: reversion by diazepam.
    Epilepsy research, 1997, Volume: 27, Issue:1

    Topics: Animals; Anticonvulsants; Chronic Disease; Cortical Spreading Depression; Diazepam; Electroencephalo

1997
[Epileptic seizures in children: acupressure instead of diazepam!. Interview by Elisabeth Moosmann M.A..].
    Fortschritte der Medizin, 1997, Feb-28, Volume: 115, Issue:6

    Topics: Acupressure; Anticonvulsants; Child; Diazepam; Epilepsy; Humans

1997
Local perfusion of diazepam attenuates interictal and ictal events in the bicuculline model of epilepsy in rats.
    Epilepsia, 1997, Volume: 38, Issue:5

    Topics: Administration, Topical; Animals; Bicuculline; Cerebral Cortex; Diazepam; Disease Models, Animal; Do

1997
Cerebral perfusion SPECT imaging in epileptic and nonepileptic seizures.
    Clinical nuclear medicine, 1997, Volume: 22, Issue:6

    Topics: Adult; Anticonvulsants; Brain; Cerebrovascular Circulation; Delta Rhythm; Depression; Diagnosis, Dif

1997
[Functional MRI employing diazepam; a proposal of neuropharmacological fMRI].
    Nihon rinsho. Japanese journal of clinical medicine, 1997, Volume: 55, Issue:7

    Topics: Anti-Anxiety Agents; Brain; Cerebrovascular Circulation; Diazepam; Epilepsy; gamma-Aminobutyric Acid

1997
Studies on quantitative beta activity in EEG background changes produced by intravenous diazepam in epilepsy.
    Clinical EEG (electroencephalography), 1997, Volume: 28, Issue:3

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Beta Rhythm; Cerebral Cortex; Child; Diazepam; Electroence

1997
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
    Epilepsy research. Supplement, 1996, Volume: 12

    Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy

1996
Interictal and ictal activity in the rat cobalt/pilocarpine model of epilepsy decreased by local perfusion of diazepam.
    Epilepsy research, 1997, Volume: 29, Issue:1

    Topics: Animals; Anticonvulsants; Cobalt; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy

1997
BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy.
    European journal of pharmacology, 1997, Nov-19, Volume: 339, Issue:1

    Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R

1997
Gaining a perspective on childhood seizures.
    The New England journal of medicine, 1998, Jun-25, Volume: 338, Issue:26

    Topics: Administration, Rectal; Adult; Child; Diazepam; Epilepsy; Humans; Recurrence; Seizures, Febrile

1998
[Potentiation of the efficacy of anticonvulsant diazepam by electrostimulation of the cerebellar cortex].
    Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 125, Issue:5

    Topics: Action Potentials; Animals; Anticonvulsants; Cats; Cerebellar Cortex; Convulsants; Diazepam; Electri

1998
Dynamic regulation of the activated, autophosphorylated state of Ca2+/calmodulin-dependent protein kinase II by acute neuronal excitation in vivo.
    Journal of neurochemistry, 1998, Volume: 71, Issue:1

    Topics: Animals; Antibody Specificity; Anticonvulsants; Calcium-Calmodulin-Dependent Protein Kinase Type 2;

1998
Who cares for students with epilepsy in mainstream education?
    Seizure, 1998, Volume: 7, Issue:3

    Topics: Administration, Rectal; Caregivers; Child; Child, Preschool; Diazepam; England; Epilepsy; Humans; Pi

1998
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
    European journal of pharmacology, 1998, Jul-24, Volume: 353, Issue:2-3

    Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod

1998
Pharmacoeconomic considerations in treatment options for acute seizures.
    Journal of child neurology, 1998, Volume: 13 Suppl 1

    Topics: Anticonvulsants; Child; Child, Preschool; Cost-Benefit Analysis; Diazepam; Economics, Pharmaceutical

1998
Chronic phenobarbital therapy reduces plasma benzodiazepine concentrations after intravenous and rectal administration of diazepam in the dog.
    Journal of veterinary pharmacology and therapeutics, 1998, Volume: 21, Issue:5

    Topics: Administration, Oral; Administration, Rectal; Animals; Anticonvulsants; Benzodiazepines; Diazepam; D

1998
PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat.
    European journal of pharmacology, 1998, Oct-16, Volume: 359, Issue:1

    Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Diazepam; Epilepsy; Hippocampus; Kainic Acid; Lamot

1998
Treatment of acute repetitive seizures.
    The New England journal of medicine, 1998, Dec-17, Volume: 339, Issue:25

    Topics: Administration, Rectal; Adult; Child; Clinical Trials as Topic; Diazepam; Epilepsy; Ethics, Medical;

1998
Buccal midazolam and rectal diazepam for epilepsy.
    Lancet (London, England), 1999, May-22, Volume: 353, Issue:9166

    Topics: Administration, Buccal; Administration, Rectal; Adolescent; Anti-Anxiety Agents; Anticonvulsants; Ch

1999
Buccal midazolam and rectal diazepam for epilepsy.
    Lancet (London, England), 1999, May-22, Volume: 353, Issue:9166

    Topics: Administration, Buccal; Administration, Intranasal; Administration, Rectal; Anti-Anxiety Agents; Ant

1999
Buccal midazolam and rectal diazepam for epilepsy.
    Lancet (London, England), 1999, May-22, Volume: 353, Issue:9166

    Topics: Administration, Buccal; Administration, Rectal; Adolescent; Anti-Anxiety Agents; Anticonvulsants; Ch

1999
Technical report: treatment of the child with simple febrile seizures.
    Pediatrics, 1999, Volume: 103, Issue:6

    Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe

1999
Rectal diazepam: pitfalls of excessive use in refractory epilepsy.
    Epilepsy research, 1999, Volume: 35, Issue:2

    Topics: Administration, Rectal; Adolescent; Adult; Diazepam; Epilepsy; Female; Humans; Male; Risk Factors

1999
Prehospital management of the seizure patient.
    Emergency medical services, 1999, Volume: 28, Issue:5

    Topics: Adolescent; Adult; Airway Obstruction; Anticonvulsants; Child; Diazepam; Emergency Medical Technicia

1999
Home and hospital treatment of acute seizures in children with nasal midazolam.
    European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 1999, Volume: 3, Issue:2

    Topics: Acute Disease; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepa

1999
The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam.
    The Chinese journal of physiology, 1999, Sep-30, Volume: 42, Issue:3

    Topics: Amino Acid Sequence; Animals; Anti-Ulcer Agents; Anticonvulsants; Antitubercular Agents; Brain Chemi

1999
[Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report].
    Arquivos de neuro-psiquiatria, 1999, Volume: 57, Issue:3B

    Topics: Adult; Anticonvulsants; Diazepam; Dupuytren Contracture; Epilepsy; Foot Diseases; Humans; Male; Phen

1999
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Apr-25, Volume: 97, Issue:9

    Topics: Acoustic Stimulation; Alprazolam; Animals; Anti-Anxiety Agents; Cognition; Conflict, Psychological;

2000
An automated drug delivery system for focal epilepsy.
    Epilepsy research, 2000, Volume: 39, Issue:2

    Topics: Animals; Anticonvulsants; Automation; Behavior, Animal; Diagnosis, Computer-Assisted; Diazepam; Drug

2000
Previous experience of withdrawal from chronic diazepam ameliorates the aversiveness of precipitated withdrawal and reduces withdrawal-induced c-fos expression in nucleus accumbens.
    The European journal of neuroscience, 2000, Volume: 12, Issue:4

    Topics: Amygdala; Animals; Avoidance Learning; Conditioning, Psychological; Corpus Striatum; Diazepam; Epile

2000
Role of ketamine in convulsions.
    Indian journal of medical sciences, 1999, Volume: 53, Issue:11

    Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therap

1999
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 294, Issue:3

    Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy

2000
Long-term reduction of benzodiazepine receptor density in the rat cerebellum by acute seizures and kindling and its recovery 6 months later by a pentylenetetrazole challenge.
    Brain research, 2001, Jan-12, Volume: 888, Issue:2

    Topics: Acute Disease; Aging; Animals; Cerebellum; Convulsants; Diazepam; Drug Administration Schedule; Epil

2001
Trimethylolpropane phosphate induces epileptiform discharges in the CA1 region of the rat hippocampus.
    Toxicology and applied pharmacology, 2001, Mar-01, Volume: 171, Issue:2

    Topics: Action Potentials; Animals; Baclofen; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam

2001
[Treatment with antiepileptic agents in patients with mental retardation and multiple handicaps].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2001, Mar-10, Volume: 121, Issue:7

    Topics: Anticonvulsants; Antipsychotic Agents; Diazepam; Disabled Persons; Epilepsy; Humans; Intellectual Di

2001
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
    Epilepsia, 2001, Volume: 42, Issue:3

    Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam;

2001
Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam.
    Neurological research, 2001, Volume: 23, Issue:6

    Topics: Ammonia; Animals; Arginine; Brain; Diazepam; Drug Interactions; Epilepsy; GABA Antagonists; GABA Mod

2001
The use of antiepileptic drugs in learning disabled people with epilepsy: an audit of adult in-patients in a treatment and continuing care service.
    Seizure, 2001, Volume: 10, Issue:7

    Topics: Adult; Anticonvulsants; Brain; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Learning

2001
Two different mechanisms of disinhibition produced by GABAA receptor mutations linked to epilepsy in humans.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Jul-01, Volume: 22, Issue:13

    Topics: Cells, Cultured; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Epilepsy; GABA M

2002
[Adverse effects of anti-epileptic drugs].
    Deutsche medizinische Wochenschrift (1946), 1975, Sep-19, Volume: 100, Issue:38

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos

1975
Proceedings: Aetiopathogenetic diagnosis of epilepsies. Influence of thiopental and diazepam on EEG epileptic phenomena.
    Electroencephalography and clinical neurophysiology, 1975, Volume: 39, Issue:5

    Topics: Diagnosis, Differential; Diazepam; Epilepsy; Humans; Thiopental

1975
How doctors deal with epilepsy.
    Lancet (London, England), 1977, Jan-22, Volume: 1, Issue:8004

    Topics: Adolescent; Adult; Aged; Automobile Driving; Diazepam; Drug Therapy, Combination; Electroencephalogr

1977
Intracranial pressure in childhood convulsions.
    Lancet (London, England), 1979, Jan-20, Volume: 1, Issue:8108

    Topics: Cerebrovascular Circulation; Child; Child, Preschool; Diazepam; Diuretics, Osmotic; Epilepsy; Humans

1979
[Clinical picture and basis for treating brain stem epilepsy].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1978, Volume: 78, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Brain Stem; Diazepam; Epilepsies, Myoclonic; Epilepsy; Female; H

1978
Seizure activity and anticonvulsant drug concentration.
    Archives of neurology, 1975, Volume: 32, Issue:5

    Topics: Anticonvulsants; Child; Circadian Rhythm; Diazepam; Dose-Response Relationship, Drug; Drug Administr

1975
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
    Arquivos de neuro-psiquiatria, 1977, Volume: 35, Issue:3

    Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia

1977
Diagnostic and prognostic significance of electroencephalography with intravenous diazepam in epilepsy.
    Folia psychiatrica et neurologica japonica, 1979, Volume: 33, Issue:1

    Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Fe

1979
[Drug therapy of epilepsy].
    Wiener medizinische Wochenschrift (1946), 1975, May-30, Volume: 125, Issue:22-24

    Topics: Anticonvulsants; Carbamazepine; Chlordiazepoxide; Clonazepam; Diazepam; Electroencephalography; Epil

1975
Involuntary movements caused by phenytoin intoxication in epileptic patients.
    Journal of neurology, neurosurgery, and psychiatry, 1975, Volume: 38, Issue:3

    Topics: Adult; Chlorpheniramine; Diazepam; Drug Interactions; Drug Therapy, Combination; Electroencephalogra

1975
Monitoring diazepam and desmethyldiazepam concentrations in plasma by gas-liquid chromatography, with use of a nitrogen-sensitive detector.
    Clinical chemistry, 1979, Volume: 25, Issue:1

    Topics: Chromatography, Gas; Diazepam; Epilepsy; Humans; Microchemistry; Nitrogen; Nordazepam

1979
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1979, Mar-23, Volume: 21, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital;

1979
Recent advances in drug therapy of some forms of childhood epilepsy.
    Paediatrician, 1979, Volume: 8 Suppl 1

    Topics: Anticonvulsants; Carbamazepine; Child; Clonazepam; Diazepam; Drug Therapy, Combination; Epilepsy; Hu

1979
Epilepsy and pregnancy.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1979, Volume: 6, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Chromosome Aberrations; C

1979
Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children.
    Archives of disease in childhood, 1979, Volume: 54, Issue:11

    Topics: Acute Disease; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Prospective Studies; Rectum; Se

1979
Epileptiform seizures with maprotiline hydrochloride.
    Postgraduate medical journal, 1979, Volume: 55, Issue:648

    Topics: Adult; Anthracenes; Diazepam; Epilepsy; Female; Humans; Male; Maprotiline; Middle Aged

1979
[Antiepileptic activity of clonazepam, a benzodiazepine antiepileptic (2). Antiepileptic effects of intravenous injection of clonazepam manifested in EEG].
    No to shinkei = Brain and nerve, 1977, Volume: 29, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepinones; Child; Clonazepam; Diazepam; Electroenc

1977
Re: "Troubles in medical academe": a clarification.
    JAMA, 1977, Jan-03, Volume: 237, Issue:1

    Topics: Amobarbital; Diazepam; Epilepsy; Heart Arrest; Humans

1977
[Drug information. Therapeutic main group: antiepileptica - anticonvulsants. Benzodiazepine derivatives].
    Sygeplejersken, 1977, Mar-09, Volume: 77, Issue:10

    Topics: Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Humans

1977
A teratological evaluation of anticonvulsant drugs.
    Acta paediatrica Academiae Scientiarum Hungaricae, 1977, Volume: 18, Issue:2

    Topics: Abnormalities, Drug-Induced; Anencephaly; Anticonvulsants; Cleft Lip; Cleft Palate; Diazepam; Epilep

1977
[Antiepileptic emergency therapy in the adult age].
    Deutsche medizinische Wochenschrift (1946), 1978, Oct-20, Volume: 103, Issue:42

    Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Phenobarbi

1978
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa).
    Neuropharmacology, 1978, Volume: 17, Issue:11

    Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitr

1978
Proposals on antiepileptic pharmacotherapy for use in developing countries.
    Epilepsia, 1976, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Developing Countries; Diazepam

1976
Diseases of the central nervous system: Epilepsy.
    British medical journal, 1975, Nov-01, Volume: 4, Issue:5991

    Topics: Age Factors; Diazepam; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Eth

1975
[Symptomatic treatment of epilepsy].
    Gaceta medica de Mexico, 1977, Volume: 113, Issue:1

    Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Phenobarbital; Phenytoin

1977
Epileptic seizures induced by psychotropic drugs.
    Psychological medicine, 1977, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Aged; Birth Order; Brain Damage, Chronic; Chlorpromazine; Diazepam; Dose-Response

1977
Letter: status epilepticus.
    JAMA, 1976, May-03, Volume: 235, Issue:18

    Topics: Diazepam; Epilepsy; Humans; Phenobarbital

1976
[Use of the Soviet preparation methindione for injections in convulsive conditions].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1976, Volume: 76, Issue:7

    Topics: Adult; Anticonvulsants; Diazepam; Drug Therapy, Combination; Epilepsy; Female; Hexobarbital; Humans;

1976
Diazepam: intravenous infusion in the treatment of status epilepticus.
    Acta neurologica Scandinavica, 1976, Volume: 54, Issue:3

    Topics: Benzoates; Chemical Precipitation; Diazepam; Drug Combinations; Drug Interactions; Epilepsy; Glucose

1976
[Side reaction after lumbar myelography with dimer-x (author's transl)].
    Zeitschrift fur Orthopadie und ihre Grenzgebiete, 1976, Volume: 114, Issue:5

    Topics: Adolescent; Adult; Diazepam; Epilepsy; Female; Humans; Iothalamic Acid; Lumbar Vertebrae; Male; Midd

1976
Letter: Sodium valproate in the treatment of intractable childhood epilepsy.
    Developmental medicine and child neurology, 1975, Volume: 17, Issue:4

    Topics: Diazepam; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Vale

1975
The influence of aldosterone and anticonvulsant drugs on electroencephalographic and clinical disturbances induced by the spirolactone derivative, potassium canrenoate.
    Journal of the neurological sciences, 1975, Volume: 24, Issue:1

    Topics: Aldosterone; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dogs; Electroencepha

1975
Ictal laughter: a case report with clinical, cinefilm, and EEG observations.
    Journal of neurology, neurosurgery, and psychiatry, 1975, Volume: 38, Issue:1

    Topics: Adolescent; Brain; Carbamazepine; Diazepam; Drug Therapy, Combination; Electroencephalography; Epile

1975
Letter: Comments on a startling article: "loss of limb following intravenous diazepam".
    Pediatrics, 1975, Volume: 55, Issue:6

    Topics: Amputation, Surgical; Arm; Benzodiazepines; Diazepam; Epilepsy; Humans; Injections, Intra-Arterial;

1975
Letter: Tranquillizers causing aggression.
    British medical journal, 1975, Apr-05, Volume: 2, Issue:5961

    Topics: Adult; Aggression; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Personality Disorders

1975
Chlormethiazole in status epilepticus--three cases.
    The Medical journal of Australia, 1975, Apr-26, Volume: 1, Issue:17

    Topics: Adult; Chlormethiazole; Diazepam; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin

1975
The management of epilepsy.
    The Medical journal of Australia, 1975, Jul-12, Volume: 2, Issue:2

    Topics: Amobarbital; Anticonvulsants; Diazepam; Drug Therapy, Combination; Emergencies; Epilepsy; Humans; Ph

1975
[Hypothermia treatment in intractable epilepsy].
    Masui. The Japanese journal of anesthesiology, 1975, Volume: 24, Issue:2

    Topics: Adolescent; Child; Diazepam; Epilepsy; Female; Humans; Hypothermia, Induced; Male

1975
Photically induced epilepsy in Papio papio as a model for drug studies.
    Advances in neurology, 1975, Volume: 10

    Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose-

1975
Status epilepticus.
    JAMA, 1975, Oct-27, Volume: 234, Issue:4

    Topics: Anesthesia, General; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Injections, Intramusc

1975
Respiratory failure as a seizure phenomenon. A case report.
    British journal of anaesthesia, 1975, Volume: 47, Issue:9

    Topics: Brain Edema; Diazepam; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Respiratory Insufficiency

1975
Drugs for epilepsy.
    The Medical letter on drugs and therapeutics, 1976, Mar-12, Volume: 18, Issue:6

    Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital;

1976
[Visual and computer evaluation of diazepam-induced EEG changes in epilepsy for localization of epileptogenic lesion].
    Zhonghua yi xue za zhi, 1992, Volume: 72, Issue:1

    Topics: Adolescent; Adult; Child; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Male; Middle A

1992
Tolerance to anticonvulsant effects of clobazam, diazepam, and clonazepam in genetically epilepsy prone rats.
    Advances in biochemical psychopharmacology, 1992, Volume: 47

    Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepino

1992
[Drug therapy in epilepsy].
    Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege, 1992, Volume: 11, Issue:3

    Topics: Anticonvulsants; Diazepam; Epilepsy; Humans

1992
Flumazenil as an anti-epileptic agent.
    Lancet (London, England), 1991, Mar-23, Volume: 337, Issue:8743

    Topics: Diazepam; Drug Evaluation; Epilepsy; Flumazenil; Humans; Time Factors

1991
Paroxysmal activity in the rabbit visual cortex induced by photostimulation.
    Biomedical science, 1991, Volume: 2, Issue:4

    Topics: Animals; Caffeine; Diazepam; Electroencephalography; Epilepsy; Pentylenetetrazole; Photic Stimulatio

1991
Brahmighritham, an Ayurvedic herbal formula for the control of epilepsy.
    Journal of ethnopharmacology, 1991, Volume: 33, Issue:3

    Topics: Administration, Oral; Animals; Diazepam; Electroencephalography; Epilepsy; Injections, Intraperitone

1991
PIVKA-II (protein induced by vitamin K absence-II) status in newborns exposed to anticonvulsant drugs in utero.
    Nihon Sanka Fujinka Gakkai zasshi, 1991, Volume: 43, Issue:3

    Topics: Adult; Anticonvulsants; Biomarkers; Diazepam; Epilepsy; Factor VII; Factor X; Female; Humans; Infant

1991
Rapid diazepam introduction (venous or rectal) in childhood epilepsy: taxonomic and therapeutic considerations.
    Brain & development, 1991, Volume: 13, Issue:1

    Topics: Administration, Rectal; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female;

1991
Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam.
    European journal of pharmacology, 1990, Mar-13, Volume: 178, Issue:1

    Topics: Animals; Diazepam; Electroencephalography; Epilepsy; Flumazenil; Hypnotics and Sedatives; Male; Rats

1990
[Therapeutic drug monitoring of clonazepam, nitrazepam and diazepam].
    Nihon rinsho. Japanese journal of clinical medicine, 1990, Volume: 48 Suppl

    Topics: Age Factors; Biological Availability; Chromatography, Gas; Chromatography, High Pressure Liquid; Chr

1990
Postnatal evolution of the gamma-aminobutyric acid/benzodiazepine receptor complex in a model of inherited epilepsy: the quaking mouse.
    Journal of neurochemistry, 1989, Volume: 52, Issue:2

    Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Diazepam; Diencephalon; Epilepsy; Flunitrazepam; gamm

1989
Clinical and EEG response to anticonvulsants in neonatal seizures.
    Archives of disease in childhood, 1989, Volume: 64, Issue:4 Spec No

    Topics: Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Paraldehyde; P

1989
Effects of diazepam and two beta-carbolines on epileptic activity and on EEG and behavior in rats with absence seizures.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1

    Topics: Animals; Anticonvulsants; Appetite Depressants; Behavior, Animal; Carbolines; Diazepam; Electroencep

1989
Phenytoin withdrawal and seizure frequency.
    Neurology, 1989, Volume: 39, Issue:7

    Topics: Adult; Carbamazepine; Diazepam; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal Lobe; Female

1989
Kainic acid-induced seizures: potentiation by alpha-methyl-p-tyrosine.
    Brain research, 1989, Aug-28, Volume: 495, Issue:2

    Topics: alpha-Methyltyrosine; Animals; Clonidine; Diazepam; Dopamine; Epilepsy; Kainic Acid; Male; Methyltyr

1989
The sz mutant hamster: a genetic model of epilepsy or of paroxysmal dystonia?
    Movement disorders : official journal of the Movement Disorder Society, 1989, Volume: 4, Issue:3

    Topics: Animals; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; Electroencephalography; Electromyog

1989
[Some suggestions on epileptic psychoses, their differential diagnosis and therapy].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1986, Volume: 38, Issue:2

    Topics: Anticonvulsants; Antipsychotic Agents; Clonazepam; Dementia; Diagnosis, Differential; Diazepam; Drug

1986
Possible destruction of cholinoceptive neurons by overstimulation of cholinergic tracts.
    Canadian journal of physiology and pharmacology, 1986, Volume: 64, Issue:3

    Topics: Animals; Brain; Choline O-Acetyltransferase; Cholinergic Fibers; Diazepam; Epilepsy; Flunitrazepam;

1986
Oral benzodiazepines as prophylaxis for epilepsy.
    Drug and therapeutics bulletin, 1986, Jun-16, Volume: 24, Issue:12

    Topics: Administration, Oral; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Clonazepam;

1986
[Convulsive attacks and the dentist].
    Actualites odonto-stomatologiques, 1988, Issue:161

    Topics: Adolescent; Child; Child, Preschool; Dental Care for Disabled; Diazepam; Emergencies; Epilepsy; Ging

1988
Benzodiazepine receptors and seizure susceptibility in epileptic fowl.
    Canadian journal of physiology and pharmacology, 1985, Volume: 63, Issue:2

    Topics: Animals; Animals, Newborn; Brain Chemistry; Chickens; Diazepam; Epilepsy; Flunitrazepam; GABA Antago

1985
[3H-diazepam binding to brain synaptic membranes during the development of generalized epileptic activity].
    Biulleten' eksperimental'noi biologii i meditsiny, 1985, Volume: 100, Issue:12

    Topics: Animals; Bemegride; Brain; Diazepam; Epilepsy; Male; Rats; Rats, Inbred Strains; Receptors, Neurotra

1985
Potent depressant action of baclofen on hippocampal epileptiform activity in vitro: possible use in the treatment of epilepsy.
    Brain research, 1986, Jul-09, Volume: 377, Issue:2

    Topics: Animals; Anticonvulsants; Baclofen; Carbamazepine; Diazepam; Epilepsy; gamma-Aminobutyric Acid; Guin

1986
Treatment of epilepsy in infancy with special emphasis on ACTH therapy.
    The Japanese journal of psychiatry and neurology, 1986, Volume: 40, Issue:3

    Topics: Administration, Rectal; Adrenocorticotropic Hormone; Diazepam; Dose-Response Relationship, Drug; Epi

1986
Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy. Comparison with other NMDA antagonists, and with diazepam and phenobarbital.
    European journal of pharmacology, 1988, Jul-26, Volume: 152, Issue:1-2

    Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Electroshock; Epilepsy; Female; Gerbill

1988
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:4

    Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; D

1986
Serum concentrations of diazepam and its metabolite desmethyldiazepam in epileptic patients after chronic diazepam treatment.
    Acta neurologica, 1986, Volume: 8, Issue:4

    Topics: Adult; Aged; Diazepam; Epilepsy; Humans; Middle Aged; Nordazepam

1986
[Epilepsy induced by penicillin in rabbits: comparative study of the anticonvulsant effects of diazepam and chlordesmethyldiazepam].
    Bollettino chimico farmaceutico, 1986, Volume: 125, Issue:6

    Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Male; Nordazepam

1986
[Modification of psychophysical performance of the human by anticonvulsants].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1987, Volume: 39, Issue:1

    Topics: Anticonvulsants; Arousal; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mental Processes;

1987
Benzodiazepine antagonist Ro 15-1788 (flumazepil) attenuates the anticonvulsant activity of diazepam in epileptic fowl.
    Brain research, 1987, Oct-20, Volume: 424, Issue:1

    Topics: Animals; Chickens; Diazepam; Epilepsy; Female; Flumazenil; Male; Poultry Diseases

1987
Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models.
    Journal of neural transmission, 1988, Volume: 71, Issue:1

    Topics: Animals; Anticonvulsants; Brain; Diazepam; Electric Stimulation; Epilepsy; gamma-Aminobutyric Acid;

1988
Comparison of the effect of althesin with diazepam and thiopental sodium on cortical and subcortical epileptic activity in the rat.
    Pharmacological research communications, 1987, Volume: 19, Issue:1

    Topics: Alfaxalone Alfadolone Mixture; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Electroencephalo

1987
Agoraphobia and paroxysmal cerebral dysrhythmia.
    The Journal of clinical psychiatry, 1987, Volume: 48, Issue:9

    Topics: Agoraphobia; Diazepam; Electroencephalography; Epilepsy; Humans; Phobic Disorders

1987
Epileptic aphasia.
    Neurology, 1987, Volume: 37, Issue:9

    Topics: Aphasia; Brain; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Humans; Male

1987
[Value of complamin and seduxen in the correction of hemodynamic disorders of epileptic children and adolescents].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1987, Volume: 87, Issue:6

    Topics: Adolescent; Anticonvulsants; Brain; Cerebrovascular Disorders; Child; Diazepam; Drug Therapy, Combin

1987
A case of parasomnia at REM sleep onset.
    The Journal of clinical psychiatry, 1987, Volume: 48, Issue:10

    Topics: Adult; Anticonvulsants; Diagnosis, Differential; Diazepam; Dreams; Epilepsy; Humans; Male; Sleep Sta

1987
Benzodiazepines in the treatment of children with epilepsy.
    Epilepsia, 1986, Volume: 27 Suppl 1

    Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Child; Child, Preschool; Clobazam; Clonazep

1986
A pharmacodynamic evaluation of midazolam as an antiepileptic compound.
    Journal of neurology, neurosurgery, and psychiatry, 1986, Volume: 49, Issue:9

    Topics: Adult; Anticonvulsants; Diazepam; Drug Therapy, Combination; Epilepsy; Female; Humans; Injections, I

1986
Anticonvulsant effects of ivermectin in genetically-epileptic chickens.
    Neuropharmacology, 1986, Volume: 25, Issue:10

    Topics: Animals; Anticonvulsants; Chickens; Diazepam; Epilepsy; Ivermectin; Mutation; Photic Stimulation; Po

1986
Hypnogenic paroxysmal dystonia: epilepsy or sleep disorder? A case report.
    Clinical EEG (electroencephalography), 1985, Volume: 16, Issue:3

    Topics: Adult; Carbamazepine; Diazepam; Dystonia; Epilepsy; Humans; Male; Sleep; Sleep Wake Disorders; Syndr

1985
Modification of strychnine epileptogenic focus in the brain cortex by diazepam.
    Activitas nervosa superior, 1985, Volume: 27, Issue:3

    Topics: Animals; Diazepam; Epilepsy; Male; Rats; Strychnine

1985
[Convulsive crises in childhood].
    Anales espanoles de pediatria, 1985, Volume: 23, Issue:8

    Topics: Clonazepam; Crying; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Mi

1985
Valium treatment in status epilepticus.
    Electroencephalography and clinical neurophysiology, 1971, Volume: 30, Issue:4

    Topics: Brain; Diazepam; Electroencephalography; Epilepsy; Humans

1971
Coarse features in epilepsy as a consequence of anticonvulsant therapy. Report of cases in two pairs of identical twins.
    Lancet (London, England), 1973, Nov-17, Volume: 2, Issue:7838

    Topics: Acromegaly; Adult; Anticonvulsants; Carbamazepine; Child; Diazepam; Diseases in Twins; Epilepsy; Epi

1973
[Calcium metabolism during antiepileptic therapy].
    Der Nervenarzt, 1973, Volume: 44, Issue:3

    Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Antipsychotic Agents; Calcium; Calcium Isotopes; Creat

1973
Clonazepam (Ro 5-4023) in the treatment of myoclonus epilepsy. Four case reports.
    Acta neurologica Scandinavica. Supplementum, 1973, Volume: 53

    Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Diazepam; Drug Therapy, Combination; Elec

1973
Phenytoin intoxication induced by sulthiame in epileptic patients.
    Journal of neurology, neurosurgery, and psychiatry, 1974, Volume: 37, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Chromatography, Gas; Diazepam; Epilepsy; Ethosuximide; Female; H

1974
[COMPLARATIVE CHARACTERISTICS OF THE CLINICAL EFFECTS OF TRANQUILIZERS].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1974, Volume: 74, Issue:9

    Topics: Anthracenes; Anti-Anxiety Agents; Benzoates; Benzodiazepinones; Chlordiazepoxide; Chlorobenzenes; Di

1974
Epilepsy.
    The Practitioner, 1974, Volume: 213, Issue:1276 SPEC

    Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec

1974
Comparative anticonvulsant effect of several Librium analogs.
    Electroencephalography and clinical neurophysiology, 1967, Volume: 23, Issue:1

    Topics: Chlordiazepoxide; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal

1967
Intravenous diazepam in seizure disorders.
    Electroencephalography and clinical neurophysiology, 1967, Volume: 23, Issue:1

    Topics: Diazepam; Electroencephalography; Epilepsy; Humans; Injections, Intravenous

1967
Observations on two kinds of post-traumatic status epilepticus.
    Electroencephalography and clinical neurophysiology, 1967, Volume: 23, Issue:2

    Topics: Accidents; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; H

1967
Further studies of i.v. diazepam (Valium) and evoked potentials of photosensitive epileptic subjects and normal controls.
    Electroencephalography and clinical neurophysiology, 1967, Volume: 23, Issue:5

    Topics: Cerebral Cortex; Diazepam; Electroretinography; Epilepsy; Evoked Potentials; Humans; Oculomotor Musc

1967
Epilepsia partialis continua (EPC) and petit mal attacks observed in the same patient.
    Electroencephalography and clinical neurophysiology, 1968, Volume: 24, Issue:1

    Topics: Adult; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Humans; Middle Aged

1968
Electro-clinical aspects of acute intoxication with chloralose.
    Electroencephalography and clinical neurophysiology, 1968, Volume: 24, Issue:5

    Topics: Acute Disease; Chloralose; Diazepam; Electroencephalography; Epilepsy; Humans; Myoclonus

1968
Evoked potential studies in response to light in the baboon (Papio papio).
    Electroencephalography and clinical neurophysiology, 1967

    Topics: Animals; Cerebral Cortex; Chlorpromazine; Diazepam; Epilepsy; Evoked Potentials; Haplorhini; Light;

1967
Demonstration by a screening method of the exceptional anti-convulsant properties of a new benzodiazepine.
    Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:1

    Topics: Benzazepines; Diazepam; Epilepsy; Humans; Hypnotics and Sedatives; Seizures

1969
Valium administration in status epilepticus and EEG follow-up.
    Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:2

    Topics: Adult; Diazepam; Electroencephalography; Epilepsy; Humans

1969
Effects of intravenous diazepam (valium) upon evoked potentials of photosensitive epileptic and normal subjects.
    Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:4

    Topics: Adult; Cerebral Cortex; Diazepam; Electrocardiography; Electroencephalography; Electromyography; Ele

1969
EEG changes after intravenous diazepam (Valium). A preliminary report.
    Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:5

    Topics: Diazepam; Electroencephalography; Epilepsy; Humans; Injections, Intravenous

1969
Intravenous diazepam (valium) as a deactivation test in epileptics.
    Electroencephalography and clinical neurophysiology, 1969, Volume: 27, Issue:7

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy;

1969
Management of convulsions.
    Lancet (London, England), 1970, Feb-21, Volume: 1, Issue:7643

    Topics: Child; Diazepam; Epilepsy; Humans; Phenobarbital; Seizures

1970
Valium and epilepsy.
    Lancet (London, England), 1970, Feb-21, Volume: 1, Issue:7643

    Topics: Animals; Child; Diazepam; Epilepsy; Haplorhini; Humans

1970
Superiority of clonazepam over diazepam in experimental epilepsy.
    Epilepsia, 1973, Volume: 14, Issue:2

    Topics: Animals; Anticonvulsants; Bemegride; Benzazepines; Cats; Cobalt; Diazepam; Disease Models, Animal; E

1973
Antiepileptic therapy and rickets in children.
    Radiology, 1973, Volume: 109, Issue:2

    Topics: Adolescent; Anticonvulsants; Barbiturates; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, To

1973
Diagnosis and treatment of childhood myoclonic seizures.
    Pediatrics, 1974, Volume: 53, Issue:4

    Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain Damage, Chronic; Bromides; Child; Child, Preschool;

1974
Diazepam treatment for acute convulsions in children. A report of 41 patients, three with plasma levels.
    Epilepsia, 1974, Volume: 15, Issue:1

    Topics: Adolescent; Age Factors; Brain Damage, Chronic; Brain Injuries; Child; Child, Preschool; Diazepam; E

1974
Therapy of seizures in children.
    American family physician, 1974, Volume: 10, Issue:3

    Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Injections, Intramuscular; Injec

1974
Prolonged trance-like stupor in epilepsy. Petit mal status-wave stupor, spaced-out status.
    Archives of internal medicine, 1974, Volume: 134, Issue:6

    Topics: Adult; Behavior; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Abse

1974
Minor motor epilepsy--a denouement.
    The Nebraska state medical journal, 1970, Volume: 55, Issue:12

    Topics: Age Factors; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant

1970
The concentration of homovanillic and 5-hydroxyindoleacetic acids in ventricular and lumbar CSF. Studies in patients with extrapyramidal disorders, epilepsy, and other diseases.
    Neurology, 1972, Volume: 22, Issue:11

    Topics: Adolescent; Adult; Basal Ganglia Diseases; Cerebral Palsy; Cerebral Ventricles; Diazepam; Dihydroxyp

1972
[Therapy of cerebral seizures in multiple-handicapped children].
    Fortschritte der Medizin, 1973, Dec-06, Volume: 91, Issue:34

    Topics: Anticonvulsants; Barbiturates; Cerebral Palsy; Child; Child, Preschool; Diazepam; Disabled Persons;

1973
[Diazepam in chronic epilepsy].
    La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1967, Feb-08, Volume: 43, Issue:7

    Topics: Chronic Disease; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Male; Middle Aged

1967
[Current criteria of medical therapy of epilepsy].
    Minerva medica, 1967, Dec-15, Volume: 58, Issue:100

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Child; Child, Preschool; Dexamethas

1967
Drug treatment of convulsive disorders.
    The New England journal of medicine, 1972, Mar-02, Volume: 286, Issue:9

    Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E

1972
Drug treatment of epilepsy in childhood.
    British medical journal, 1969, Nov-22, Volume: 4, Issue:5681

    Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Absence; Epil

1969
A comprehensive scheme for the evaluation of anticonvulsant concentrations in blood using thin-layer chromatography.
    Clinica chimica acta; international journal of clinical chemistry, 1971, Volume: 35, Issue:1

    Topics: Acetazolamide; Anticonvulsants; Benzazepines; Carbamazepine; Chlordiazepoxide; Chromatography, Thin

1971
[Neuroleptics, thymoleptics and tranquilizers in neurological therapy].
    Bibliotheca psychiatrica et neurologica, 1969, Volume: 139

    Topics: Basal Ganglia Diseases; Chlordiazepoxide; Chlorpromazine; Diazepam; Epilepsy; Extrapyramidal Tracts;

1969
[Medical treatment of epilepsy].
    Harefuah, 1971, Apr-01, Volume: 80, Issue:7

    Topics: Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Hydantoins;

1971
[Therapy of epilepsy. The causes and consequences of inadequate treatment].
    Deutsche medizinische Wochenschrift (1946), 1972, Oct-13, Volume: 97, Issue:41

    Topics: Acridines; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Barbiturates; Carbamazepine; Child

1972
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
    Drugs, 1972, Volume: 4, Issue:3

    Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog

1972
Status epilepticus.
    American family physician, 1974, Volume: 10, Issue:4

    Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb

1974
[Effect of Faustan (diazepam) on the EEG of epileptics].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1974, Volume: 26, Issue:7

    Topics: Adolescent; Adult; Child; Diazepam; Drug Evaluation; Electroencephalography; Epilepsy; Humans; Injec

1974
[Considerations and research on febrile convulsions].
    Minerva pediatrica, 1974, Apr-14, Volume: 26, Issue:13

    Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencepha

1974
Prescribing in pregnancy.
    The Practitioner, 1974, Volume: 212, Issue:1271

    Topics: Carbimazole; Chlorpromazine; Diabetes Mellitus; Diazepam; Drug Prescriptions; Epilepsy; Female; Fetu

1974
[Letter: Diazepam (Valium)].
    Anasthesiologische und intensivmedizinische Praxis, 1974, Volume: 9, Issue:1

    Topics: Child; Diazepam; Drug Tolerance; Epilepsy; Humans; Infant; Injections, Intravenous

1974
Editorial: Management of status epilepticus.
    The New Zealand medical journal, 1974, Feb-27, Volume: 79, Issue:509

    Topics: Barbiturates; Diazepam; Epilepsy; Humans; Paraldehyde; Phenytoin

1974
Anticonvulsant drug-serum levels in psychiatric patients with seizure disorders. Effects of certain psychotropic drugs.
    New York state journal of medicine, 1974, Volume: 74, Issue:9

    Topics: Chlorpromazine; Chromatography, Gas; Diazepam; Drug Interactions; Epilepsy; Humans; Mental Disorders

1974
Penicillin-induced epileptogenic foci. I. Time course and the anticonvulsant effects of diphenylhydantoin and diazepam.
    Neuropharmacology, 1974, Volume: 13, Issue:4

    Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Cerebral Ventricles; Diazepam; Dose-Response Relati

1974
Diazepam as an oral long-term anticonvulsant for epileptic mental patients.
    Diseases of the nervous system, 1972, Volume: 33, Issue:2

    Topics: Amobarbital; Anticonvulsants; Diazepam; Epilepsy; Evaluation Studies as Topic; Female; Humans; Long-

1972
The action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats.
    Epilepsia, 1972, Volume: 13, Issue:3

    Topics: Animals; Anticonvulsants; Bemegride; Carbamazepine; Cats; Cobalt; Diazepam; Electroencephalography;

1972
Tonic status epilepticus precipitated by intravenous diazepam in a child with petit mal status.
    Epilepsia, 1972, Volume: 13, Issue:3

    Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Female; Hemiplegia; Humans

1972
[Fever convulsions].
    Deutsche medizinische Wochenschrift (1946), 1972, Oct-20, Volume: 97, Issue:42

    Topics: Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Fever; Humans; Long-Term Care;

1972
Electroencephalographic analysis of atropine coma.
    Acta physiologica Academiae Scientiarum Hungaricae, 1972, Volume: 41, Issue:1

    Topics: Atropine; Barbiturates; Bipolar Disorder; Coma; Delirium; Diazepam; Electroencephalography; Epilepsy

1972
[Diazepam Spofa-an anxiolytic agent with anticonvulsive and myorelaxant effects].
    Casopis lekaru ceskych, 1973, Mar-30, Volume: 112, Issue:13

    Topics: Anticonvulsants; Anxiety; Diazepam; Epilepsy; Humans; Neuromuscular Depolarizing Agents; Neurotic Di

1973
[Convulsions in children].
    La Vie medicale au Canada francais, 1973, Volume: 2, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Birth Injuries; Brain Diseases; Brain Injuries; Child; Child, Pr

1973
[Ambulatory extended care for the child with seizures].
    Zeitschrift fur arztliche Fortbildung, 1973, Apr-01, Volume: 67, Issue:7

    Topics: Adolescent; Age Factors; Ambulatory Care; Child; Child, Preschool; Diazepam; Epilepsy; Ethosuximide;

1973
Diazepam suppositories in prolonged convulsions.
    British medical journal, 1973, Aug-25, Volume: 3, Issue:5877

    Topics: Child; Diazepam; Epilepsy; Female; Humans; Suppositories

1973
[Use of diazepam (Valium) as a supplementary diagnostic medium during electroencephalography for epilepsy].
    Ceskoslovenska neurologie, 1973, Volume: 36, Issue:5

    Topics: Adolescent; Adult; Child; Diazepam; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Mid

1973
Epileptic pain. An uncommon manifestation with localizing value.
    Neurology, 1973, Volume: 23, Issue:5

    Topics: Adenocarcinoma; Adult; Brain Neoplasms; Cerebral Angiography; Diazepam; Epilepsy; Female; Humans; Ma

1973
Intravenous diazepam in status epilepticus: a correction.
    Pediatrics, 1973, Volume: 51, Issue:5

    Topics: Child; Diazepam; Epilepsy; Humans; Injections, Intravenous

1973
[Differential diagnosis and emergency treatment of epileptic seizures].
    Wiener medizinische Wochenschrift (1946), 1973, Oct-06, Issue:40

    Topics: Anticonvulsants; Arrhythmias, Cardiac; Diagnosis, Differential; Diazepam; Emergencies; Epilepsy; Hum

1973
[Use of diazepam (Valium) as an auxillary diagnostic aid in electroencephalography of epilepsy].
    Ceskoslovenska neurologie a neurochirurgie, 1973, Volume: 36, Issue:5

    Topics: Adolescent; Adult; Child; Diazepam; Electroencephalography; Epilepsy; Humans; Methods; Middle Aged

1973
[Neuro-psychiatric evaluation of Clonazepam (Ro 5-4023) in epileptic patients].
    Gaceta medica de Mexico, 1973, Volume: 106, Issue:5

    Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Evaluation

1973
Serum concentrations of diazepam in subjects with epilepsy.
    Archives of neurology, 1973, Volume: 29, Issue:3

    Topics: Administration, Oral; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Electroencephalog

1973
Diazepam as an anticonvulsant.
    Neurology India, 1973, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Male; Middle Aged

1973
Loss of limb following intravenous diazepam.
    Pediatrics, 1974, Volume: 53, Issue:1

    Topics: Arm; Child, Preschool; Diazepam; Epilepsy; Hand; Humans; Injections, Intra-Arterial; Injections, Int

1974
Emergency management of the patient with seizures. 1. Generalized status epilepticus.
    Postgraduate medicine, 1974, Volume: 55, Issue:2

    Topics: Airway Obstruction; Anesthesia, General; Anticonvulsants; Blood Pressure Determination; Blood Specim

1974
Abnormal scintiangiographic findings associated with seizure activity.
    Radiology, 1974, Volume: 111, Issue:1

    Topics: Adult; Cerebrovascular Circulation; Child; Diazepam; Epilepsy; Female; Humans; Male; Paraldehyde; Ra

1974
Letter: Diazepam for management of seizures.
    Postgraduate medicine, 1974, Volume: 55, Issue:4

    Topics: Diazepam; Epilepsy; Glucose; Humans; Infusions, Parenteral; Phlebitis; Sodium Chloride

1974
Infants exposed in utero to antiepileptic drugs. A prospective study.
    American journal of diseases of children (1960), 1974, Volume: 127, Issue:5

    Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro

1974
Pharmacology for the pediatrician. Noncompliance contributing to apparent drug failure in status epilepticus.
    Pediatrics, 1974, Volume: 53, Issue:6

    Topics: Anticonvulsants; Benzodiazepinones; Child; Chlorobenzenes; Diazepam; Epilepsy; Ethosuximide; Female;

1974
Diazepam (valium) in the treatment of epilepsy. A report of fifty cases.
    Acta neurologica Scandinavica. Supplementum, 1965, Volume: 13 Pt 2

    Topics: Adolescent; Adult; Anticonvulsants; Child; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal

1965
Treatment of status epilepticus with diazepam.
    Neurology, 1966, Volume: 16, Issue:7

    Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Female; Huma

1966
[On the treatment of the status epilepticus with diazepam (Valium). Experiences in 12 cases].
    Schweizerische medizinische Wochenschrift, 1966, Jan-29, Volume: 96, Issue:4

    Topics: Adolescent; Adult; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Humans; Male; Mid

1966
[Status elepticus].
    Praxis, 1967, Jun-01, Volume: 56, Issue:22

    Topics: Barbiturates; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenytoin

1967
[On the syndrome of progessive myoclonus epilepsy according to Lundborg. (A clinical course observation for fifteen years)].
    Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie, 1968, Volume: 102, Issue:1

    Topics: Adult; Cachexia; Cerebellar Diseases; Dementia; Diazepam; Electroencephalography; Electromyography;

1968
Dangers of treatment of status epilepticus with diazepam.
    British medical journal, 1969, Jan-18, Volume: 1, Issue:5637

    Topics: Adolescent; Adult; Aged; Cheyne-Stokes Respiration; Child; Diazepam; Drug Antagonism; Epilepsies, Pa

1969
[Diagnosis and treatment of Unverricht-Lundborg type progressive myoclonic epilepsy].
    Acta neurologica et psychiatrica Belgica, 1968, Volume: 68, Issue:7

    Topics: Adult; Biopsy; Blood Chemical Analysis; Brain; Cerebrospinal Fluid; Diagnosis, Differential; Diazepa

1968
Parenteral diazepam in status epilepticus.
    Neurology, 1969, Volume: 19, Issue:4

    Topics: Adolescent; Adult; Aged; Alcoholism; Brain Neoplasms; Child; Child, Preschool; Diazepam; Electroence

1969
The long-term oral use of valium (diazepam) in epilepsy.
    Epilepsia, 1969, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsies, Partial; E

1969
Electroencephalographic studies on the anticonvulsive action of intravenous diazepam.
    European neurology, 1970, Volume: 3, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epile

1970
Intravenous diazepam and its anticonvulsive action.
    The Johns Hopkins medical journal, 1970, Volume: 127, Issue:2

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography;

1970
[Diazepam (Faustan) as a drug of choice for the treatment of status epilepticus and long-lasting attacks in childhood].
    Das Deutsche Gesundheitswesen, 1970, Apr-16, Volume: 25, Issue:15

    Topics: Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Infa

1970
Spike-wave stupor. Petit mal status.
    American journal of diseases of children (1960), 1971, Volume: 121, Issue:4

    Topics: Anticonvulsants; Child; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Ethosuximide;

1971
Diazepam in the treatment of childhood epilepsy.
    JAMA, 1971, Mar-29, Volume: 215, Issue:13

    Topics: Administration, Oral; Age Factors; Child; Child, Preschool; Diazepam; Drug Tolerance; Electroencepha

1971
[Problems of treatment of epilepsy].
    Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3

    Topics: Anemia, Macrocytic; Anticonvulsants; Bromides; Diazepam; Drug Synergism; Epilepsy; Epilepsy, Tempora

1971
[Results of treatment of epilepsy in children up to 14 years of age].
    Neurologia i neurochirurgia polska, 1971, Volume: 5, Issue:3

    Topics: Adolescent; Age Factors; Barbiturates; Child; Child, Preschool; Diazepam; Drug Synergism; Electroenc

1971
[Intravenous use of nitrazepam (Mogadan) in the treatment of epilepsy].
    Neuropadiatrie, 1970, Volume: 2, Issue:1

    Topics: Administration, Oral; Benzazepines; Child; Child, Preschool; Diazepam; Electroencephalography; Epile

1970
[Cerebral seizures (conclusion). 4. Therapy].
    Fortschritte der Medizin, 1971, Sep-09, Volume: 89, Issue:25

    Topics: Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Epileps

1971
[Injectable diazepam (Seduxen, Valium) in the treatment of recurrent epileptic seizures in childhood].
    Orvosi hetilap, 1972, Jan-16, Volume: 113, Issue:3

    Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Injections, Int

1972
[The problem of convulsions in children. Considerations on the use of diazepam by intravenous injection].
    Minerva pediatrica, 1972, Jan-14, Volume: 24, Issue:1

    Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Infant; Infant,

1972
Status epilepticus.
    British medical journal, 1972, Mar-04, Volume: 1, Issue:5800

    Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Paraldehyde

1972
Minor epileptic status.
    Developmental medicine and child neurology, 1972, Volume: 14, Issue:1

    Topics: Brain Diseases; Child; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Phenytoin; Primidone

1972
[Therapy of epilepsy].
    Minerva medica, 1972, May-26, Volume: 63, Issue:40

    Topics: Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Humans; Hydantoins; Primidone; Suc

1972
[Convulsive seizure, an urgent therapeutic problem].
    Wiener medizinische Wochenschrift (1946), 1972, May-06, Volume: 122, Issue:19

    Topics: Age Factors; Child, Hospitalized; Child, Preschool; Diazepam; Emergencies; Epilepsy; Humans; Infant

1972
Obstacle to pediatric therapy.
    Pediatrics, 1972, Volume: 50, Issue:3

    Topics: Age Factors; Child; Child, Preschool; Diazepam; Drug and Narcotic Control; Epilepsy; Humans; United

1972
Epilepsy in multiple sclerosis.
    Journal of the neurological sciences, 1972, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Barbiturates; Basal Ganglia; Carbamazepine; Cerebral Cortex; Demyelinating Diseas

1972
[Therapy of status epilepticus].
    Ceskoslovenska pediatrie, 1971, Volume: 26, Issue:6

    Topics: Adolescent; Anticonvulsants; Barbiturates; Child; Child, Preschool; Diazepam; Diuretics; Electroence

1971
Sedation for the mentally handicapped dental patient.
    Anaesthesia, 1971, Volume: 26, Issue:3

    Topics: Adolescent; Aggression; Anesthesia, Dental; Anesthesia, Local; Benperidol; Child; Child, Preschool;

1971
[Value of benzodiazepins injected by the intravenous route].
    Journal de medecine de Lyon, 1971, Jun-05, Volume: 52, Issue:210

    Topics: Benzazepines; Brain Diseases; Diazepam; Electroencephalography; Epilepsy; Humans; Injections, Intrav

1971
Diazepam for epilepsy.
    Drug and therapeutics bulletin, 1971, Oct-22, Volume: 9, Issue:22

    Topics: Administration, Oral; Child; Diazepam; Electroencephalography; Epilepsy; Humans; Hypotension; Inject

1971
[Experience in the use of seduxen in ampules in the treatment of epileptic status].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1971, Volume: 71, Issue:12

    Topics: Adolescent; Adult; Diazepam; Epilepsy; Humans; Injections, Intramuscular; Injections, Intravenous; M

1971
[Valium in the therapy of epileptic status].
    Neuropsihijatrija, 1971, Volume: 19, Issue:1

    Topics: Adult; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Injections, Intravenous; Male; Se

1971
[Anticonvulsants. 2. Pharmacodynamics].
    Lakartidningen, 1971, Oct-18, Volume: 68

    Topics: Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Humans; Hydantoins; Oxazoles; Prim

1971
[Parenteral diazepam in the treatment of severe epilepsy].
    Arquivos de neuro-psiquiatria, 1971, Volume: 29, Issue:3

    Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Huma

1971
[Therapeutic possibilities in the treatment of problem patients].
    Deutsche zahnarztliche Zeitschrift, 1968, Volume: 23, Issue:7

    Topics: Adult; Anesthesia, Endotracheal; Child; Diazepam; Epilepsy; Humans; Hypnotics and Sedatives; Mental

1968
New treatment for old neurologic disease. Status epilepticus treatment with diazepam.
    New York state journal of medicine, 1970, Oct-01, Volume: 70, Issue:19

    Topics: Adult; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans

1970
The effects of eserine and atropine on the epileptiform activity of chronically isolated cortex.
    Epilepsia, 1971, Volume: 12, Issue:2

    Topics: Acetylcholine; Animals; Atropine; Cats; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy;

1971
Status epilepticus in infants and young children treated with parenteral diazepam.
    Archives of disease in childhood, 1969, Volume: 44, Issue:237

    Topics: Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Infant, Newborn; Injections, In

1969
[Demonstration of the exceptional anti-epileptic properties of a new benzodiazepine using a screening technic].
    Revue neurologique, 1969, Volume: 120, Issue:6

    Topics: Administration, Oral; Anticonvulsants; Benzazepines; Diazepam; Electroencephalography; Epilepsy; Hum

1969
[Experimental electrographic study comparing the anti-epileptic properties of a new benzodiazepine derivative the Ro 5-4023].
    Revue neurologique, 1969, Volume: 120, Issue:6

    Topics: Anticonvulsants; Benzazepines; Brain; Chlordiazepoxide; Diazepam; Electroencephalography; Epilepsy;

1969
[Therapy of epilepsy].
    Bibliotheca psychiatrica et neurologica, 1969, Volume: 139

    Topics: Activities of Daily Living; Anticonvulsants; Barbiturates; Diazepam; Electroencephalography; Epileps

1969
The action of diazepam in neurological disorders with excessive motor activity.
    Journal of the neurological sciences, 1970, Volume: 10, Issue:1

    Topics: Brain Diseases; Decerebrate State; Diazepam; Diencephalon; Electromyography; Epilepsy; Hemiplegia; H

1970
Treatment of status epilepticus in dogs with diazepam sodium.
    Journal of the American Veterinary Medical Association, 1970, Feb-15, Volume: 156, Issue:4

    Topics: Animals; Barbiturates; Diazepam; Dog Diseases; Dogs; Epilepsy; Female; Injections, Intravenous; Male

1970
[Therapy of epileptic mal states].
    Bordeaux medical, 1970, Volume: 3, Issue:2

    Topics: Diazepam; Epilepsy; Humans; Seizures

1970
Valium in management of status epilepticus: a correction.
    Pediatrics, 1970, Volume: 45, Issue:3

    Topics: Diazepam; Epilepsy; Humans; Injections, Intravenous; Seizures

1970
The effect of diazepam on the EEG of status epilepticus.
    Journal of neurology, neurosurgery, and psychiatry, 1970, Volume: 33, Issue:2

    Topics: Adult; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Injections, Intravenous; Male; Mi

1970
[Influencing of refractory epilepsies by deep cerebral hypothermia].
    Ceskoslovenska neurologie, 1970, Volume: 33, Issue:4

    Topics: Adolescent; Adult; Child; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Hypothermia, I

1970
General and local hypothermia of the brain in the treatment of intractable epilepsy.
    Journal of neurosurgery, 1970, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Body Temperature; Child; Diazepam; Electroencephalography; Epilepsy; Female; Foll

1970
Diazepam--the new wonder drug?
    Developmental medicine and child neurology, 1970, Volume: 12, Issue:5

    Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant

1970
Diazepam in the management of epilepsy.
    The British journal of psychiatry : the journal of mental science, 1970, Volume: 117, Issue:537

    Topics: Adult; Age Factors; Aged; Diazepam; Epilepsy; Female; Follow-Up Studies; Humans; Male; Middle Aged;

1970
Gelastic epilepsy.
    Journal of neurology, neurosurgery, and psychiatry, 1970, Volume: 33, Issue:4

    Topics: Adolescent; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Hyp

1970
[The basic criteria for clinical evaluation of the effect of tranquilizers].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1970, Volume: 70, Issue:12

    Topics: Benactyzine; Bipolar Disorder; Central Nervous System Diseases; Chlordiazepoxide; Diazepam; Epilepsy

1970
[Status epilepticus].
    Neuropsihijatrija, 1970, Volume: 18, Issue:2

    Topics: Diazepam; Electroencephalography; Epilepsy; Humans; Phenytoin

1970
Electroclinical aspects of remission of status epilepticus.
    Revue roumaine de neurologie, 1970, Volume: 7, Issue:3

    Topics: Adult; Alpha Rhythm; Automatism; Barbiturates; Cognition Disorders; Diazepam; Electroencephalography

1970
[Seduxen treatment of status epilepticus].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1971, Volume: 71, Issue:3

    Topics: Adolescent; Adult; Aged; Alcoholism; Craniocerebral Trauma; Diazepam; Electroencephalography; Epilep

1971
[Electro-clinical aspects of acute poisoning by chloralose].
    Revue neurologique, 1967, Volume: 117, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aspirin; Cerebral Cortex; Chloralose; Diazepam; Electroencephalogr

1967
[Contribution of daizepam (valium) to the completion of cardiazolic activation in clinical electroencephalography].
    L'union medicale du Canada, 1967, Volume: 96, Issue:3

    Topics: Diazepam; Drug Synergism; Electroencephalography; Epilepsy; Humans; Pentylenetetrazole

1967
[Injection of barbiturates in status epilepticus].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1968, Feb-15, Volume: 88, Issue:4

    Topics: Barbiturates; Diazepam; Epilepsy; Humans; Injections, Intramuscular; Injections, Intravenous; Seizur

1968
Remarks on the EEG and movement disorder in SSPE.
    Neurology, 1968, Volume: 18, Issue:1 Pt 2

    Topics: Brain; Cerebral Cortex; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Diffuse Cerebral

1968
E.C.T. phases with and without anaesthesia: a preliminary statistical study.
    The British journal of psychiatry : the journal of mental science, 1968, Volume: 114, Issue:516

    Topics: Amobarbital; Anesthesia; Diazepam; Electroconvulsive Therapy; Epilepsy; Humans; Methohexital; Reacti

1968
Seduxen in neuropsychiatry.
    Therapia Hungarica (English edition), 1968, Volume: 16, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Diazepam; Epilepsy; Female; Hemiplegia; Humans; Male; Middle Aged; N

1968
Recent advances in treating epileptic children.
    Postgraduate medicine, 1968, Volume: 44, Issue:6

    Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Ethosuximide; Humans; Quinacrine

1968
The treatment of recurrent convulsions with intravenous injection of diazepam.
    The Medical clinics of North America, 1968, Volume: 52, Issue:4

    Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Diazepam; Epilepsy; Female; Humans; Injections, Int

1968
[Changing of the photosensible threshold in the electroencephalogram by drugs acting in the central nervous system].
    Arztliche Forschung, 1968, May-10, Volume: 22, Issue:5

    Topics: Adolescent; Adult; Aged; Barbiturates; Central Nervous System; Child; Diazepam; Electroencephalograp

1968
[Comparative studies on the action profile of some benzodiazepine derivatives].
    Arzneimittel-Forschung, 1968, Volume: 18, Issue:12

    Topics: Anticonvulsants; Anxiety Disorders; Benzazepines; Chlordiazepoxide; Diazepam; Epilepsy; Humans; Hypn

1968
[Treatment of infantile spasms with nitrazepam].
    No to shinkei = Brain and nerve, 1968, Volume: 20, Issue:12

    Topics: Adrenal Cortex Hormones; Anticonvulsants; Child, Preschool; Diazepam; Drug Synergism; Epilepsy; Huma

1968
Status epilepticus and diazepam.
    British medical journal, 1969, Mar-15, Volume: 1, Issue:5645

    Topics: Diazepam; Drug Synergism; Epilepsy; Humans; Hypotension

1969
The intravenous use of diazepam in focal status epilepticus.
    Southern medical journal, 1969, Volume: 62, Issue:4

    Topics: Adult; Aged; Alcoholism; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Injections, Int

1969
[Treatment of the condition of epilepsy in children by diazepam].
    Revue medicale de Liege, 1969, Mar-15, Volume: 24, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Male

1969
Medical therapy of epilepsy.
    Wisconsin medical journal, 1969, Volume: 68, Issue:4

    Topics: Anticonvulsants; Diazepam; Epilepsy; Ethosuximide; Humans; Succinimides

1969
"Half and half" seizures.
    Developmental medicine and child neurology, 1969, Volume: 11, Issue:1

    Topics: Adolescent; Diazepam; Electroencephalography; Epilepsy; Humans; Male; Reflex

1969
Effect of drugs on the somatosensory evoked potentials in myoclonic epilepsy.
    Archives of neurology, 1969, Volume: 20, Issue:4

    Topics: Adult; Benzazepines; Diazepam; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Male; Me

1969
[The convulsive child].
    Duodecim; laaketieteellinen aikakauskirja, 1969, Volume: 85, Issue:10

    Topics: Acute Disease; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Muscle

1969
Diazepam: its scope in anaesthetic practice.
    Proceedings of the Royal Society of Medicine, 1969, Volume: 62, Issue:8

    Topics: Adult; Amnesia; Anesthesia, Dental; Anesthesia, Obstetrical; Cardiac Catheterization; Cardiac Surgic

1969
[Use in electroencephalographic practice of a rapid-acting injectable anticonvulsant (Diazepam)].
    Revue neurologique, 1965, Volume: 113, Issue:3

    Topics: Diazepam; Electroencephalography; Epilepsy; Humans

1965
[The action of diazepam (Valium) in the treatment of nonconvulsive forms of generalized epilepsy (absences and absence states of various types)].
    Revue neurologique, 1965, Volume: 112, Issue:2

    Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Male; Middle Aged

1965
[Preliminary note on the effects of diazepam in epilepsy].
    Medicina clinica, 1965, Volume: 45, Issue:2

    Topics: Adolescent; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Male

1965
[Intravenous methyldiazepinone in an epileptic state appearing at the termination of anesthesia].
    Acta anaesthesiologica, 1965, Volume: 16

    Topics: Adult; Diazepam; Epilepsy; Female; Humans; Injections, Intravenous; Postoperative Complications; Sei

1965
[The treatment of status epilepticus with "diazepam". Clinical study and electroencephalographic documentation. Preliminary notes].
    Minerva medica, 1966, Feb-03, Volume: 57, Issue:10

    Topics: Adult; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Male

1966
Tap seizures. A form of sensory precipitation epilepsy.
    JAMA, 1966, Oct-31, Volume: 198, Issue:5

    Topics: Birth Injuries; Child, Preschool; De Lange Syndrome; Diazepam; Electroencephalography; Electromyogra

1966