diazepam has been researched along with Aura in 530 studies
Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration." | 9.41 | Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. ( Biton, V; Carrazana, E; Cascino, GD; Cook, DF; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021) |
| " Diazepam nasal spray (Valtoco®) is a proprietary intranasal formulation approved for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) in patients with epilepsy aged ≥6 years." | 9.41 | Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study. ( Carrazana, E; Cascino, GD; Davis, C; Desai, J; Hogan, RE; Liow, K; Rabinowicz, AL; Sperling, MR; Tarquinio, D; Wheless, JW, 2021) |
| "A Phase 3 open-label safety study (NCT02721069) evaluated long-term safety of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters." | 9.41 | Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. ( Biton, V; Carrazana, E; Cascino, GD; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Mauney, W; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021) |
| "To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states." | 9.34 | Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study. ( Carrazana, E; Hogan, RE; Klein, P; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D, 2020) |
| "In this phase III, randomized, double‐blind, parallel‐group, placebo‐controlled, multicenter study, subjects with epilepsy on a stable antiepileptic drug regimen who required intermittent medical intervention to control ARS were randomized 1:1 to the placebo AI or the diazepam AI group." | 9.17 | A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures. ( Abou-Khalil, B; Goli, V; Pixton, GC; Rogin, J; Roland, CL; Sherman, NA; Shukla, RB; Sommerville, K; Wheless, J; Wolter, KD, 2013) |
| "To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy." | 9.14 | Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy. ( Adelgais, K; Dudley, N; Filloux, F; Firth, S; Greenberg, R; Healy, A; Holsti, M; Olsen, C; Schunk, J, 2010) |
| "The purpose of these investigations was to determine from combined data the response to rectal diazepam (DZP) gel (Diastat [Athena Neurosciences, South San Francisco, CA]) in home treatment of children with episodes of acute repetitive seizures (ARS)." | 9.09 | Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group. ( Cereghino, JJ; Cloyd, JC; Kriel, RL; Mitchell, WG; Pellock, JM; Rosman, NP, 1999) |
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 9.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "Lamotrigine, a novel anticonvulsant, has been evaluated in patients with epilepsy using the method of interictal EEG spike counting." | 9.06 | The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy. ( Jawad, S; Oxley, J; Richens, A; Yuen, WC, 1986) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 8.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 8.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| "We gained insights into NfL levels during the various phases of the intrahippocampal kainic acid mouse model of temporal lobe epilepsy-namely, the status epilepticus (SE) and the chronic phase with spontaneous seizures." | 8.31 | Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy? ( Barbé, K; Bjerke, M; Custers, ML; Kaltenböck, L; Smolders, I; Van Eeckhaut, A; Vande Vyver, M, 2023) |
| "Patients prescribed sublingual lorazepam solution at the Johns Hopkins Epilepsy Center for acute seizure treatment during a 5-year period (2012-2017) were screened." | 8.31 | Sublingual lorazepam as rescue therapy for seizure emergencies in adults. ( Krauss, GL; Lelis, IR, 2023) |
| " In vivo, C57BL/6 mice that received intrahippocampal WNK463 experienced delayed onset of kainic acid-induced status epilepticus, less epileptiform EEG activity, and did not develop pharmaco-resistance to diazepam." | 8.12 | Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus. ( Abiraman, K; Brandon, NJ; Deeb, TZ; Lee, KL; Lucaj, C; Maguire, J; Moss, SJ; Ollerhead, TA, 2022) |
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 7.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| "Rectal diazepam solution, administered by capable caregivers, is as effective and safe as rectal administration of IVD for children with intractable epilepsy." | 7.77 | Rectal diazepam solution is as good as rectal administration of intravenous diazepam in the first-aid cessation of seizures in children with intractable epilepsy. ( Chen, YI; Chiang, LM; Chou, ML; Deng, ST; Hung, PC; Lin, KL; Shen, HH; Tseng, CH; Wang, HS, 2011) |
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 7.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 7.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 7.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "The rectal administration of diazepam (DZP) has provided a safer existence to many epilepsy patients and their carers, when prolonged or serial seizures are present." | 7.70 | Rectal diazepam: pitfalls of excessive use in refractory epilepsy. ( Aamo, T; Brodtkorb, E; Henriksen, O; Lossius, R, 1999) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 7.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 7.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 7.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "Diazepam-induced EEG changes were analyzed both visually and by computer in epilepsy for localization of epileptogenic lesion." | 7.68 | [Visual and computer evaluation of diazepam-induced EEG changes in epilepsy for localization of epileptogenic lesion]. ( Huang, Z, 1992) |
| "Rapid diazepam (DZP) introduction was investigated in 24 children with different types of cryptogenic or symptomatic generalized epilepsy and EEG epileptic "status" with EEG and pharmacologic monitoring." | 7.68 | Rapid diazepam introduction (venous or rectal) in childhood epilepsy: taxonomic and therapeutic considerations. ( Baglietto, MG; De Negri, M; Gaggero, R; Pallecchi, A; Pessagno, A; Veneselli, E, 1991) |
| "The mechanisms underlying tolerance to benzodiazepines were investigated by injecting diazepam (5 mg/kg) twice daily for 23 days in WAG/Rij rats (an animal model for non-convulsive absence epilepsy)." | 7.68 | Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam. ( Coenen, AM; Nutt, DJ; Peeters, BW; Titulaer, MN; Van Rijn, CM; Vossen, JM, 1990) |
| "Thirty cases of intractable epilepsy in children were investigated to observe the correlation between the suppression of seizure discharges to intravenous diazepam and the type of seizure or effects of subsequent therapy." | 7.66 | Diagnostic and prognostic significance of electroencephalography with intravenous diazepam in epilepsy. ( Goya, N; Kurokawa, T; Mitsudome, A; Shibata, R; Takashima, S; Yokota, K, 1979) |
| " Safety assessments included treatment-emergent adverse events (TEAEs)." | 7.11 | Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study. ( Carrazana, E; Desai, J; Dlugos, D; Rabinowicz, AL; Tarquinio, D; Wheless, JW, 2022) |
| " Adverse events (AEs) and usability assessments were recorded after the first dose, then every 3 months." | 6.94 | Safety and tolerability associated with chronic intermittent use of diazepam buccal film in adult, adolescent, and pediatric patients with epilepsy. ( Buan, C; Gelfand, MA; Heller, AH; Seinfeld, S; Slatko, G, 2020) |
| "Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population." | 6.82 | Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016) |
| "No patient in the VPA group developed respiratory depression, hypotension, or hepatic dysfunction, whereas in the DZP group, 5." | 6.76 | Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. ( Chen, WB; Fan, CQ; Gao, R; Ren, Y; Su, YY; Wang, L; Zhang, YZ; Zhao, JW, 2011) |
| " Currently, Diazepam rectal gel is the only approved therapy for the outpatient management of seizures, but there is a growing need for alternative medications for terminating seizures that may be not only safe and effective but also socially acceptable." | 6.52 | Safety and efficacy of diazepam autoinjector for the management of epilepsy. ( Milioni, M; Verrotti, A; Zaccara, G, 2015) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| " Diazepam rectal gel, intranasal midazolam, and diazepam nasal spray are US Food and Drug Administration (FDA)-approved seizure-cluster rescue medications, and intravenous diazepam and lorazepam are approved for status epilepticus." | 5.41 | Acute Abortive Therapies for Seizure Clusters in Long-Term Care. ( Becker, DA; Birnbaum, AK; Carrazana, E; Misra, SN; Rabinowicz, AL; Ramsay, RE; Vazquez, B, 2023) |
| "Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration." | 5.41 | Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study. ( Biton, V; Carrazana, E; Cascino, GD; Cook, DF; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021) |
| " Diazepam nasal spray (Valtoco®) is a proprietary intranasal formulation approved for the acute treatment of intermittent, stereotypic episodes of frequent seizure activity (ie, seizure clusters, acute repetitive seizures) in patients with epilepsy aged ≥6 years." | 5.41 | Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study. ( Carrazana, E; Cascino, GD; Davis, C; Desai, J; Hogan, RE; Liow, K; Rabinowicz, AL; Sperling, MR; Tarquinio, D; Wheless, JW, 2021) |
| " Diazepam nasal spray is approved to treat seizure clusters in patients with epilepsy ≥6 years of age." | 5.41 | Consistent safety and tolerability of Valtoco ( Biton, V; Carrazana, E; Cascino, GD; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Mauney, W; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021) |
| "A Phase 3 open-label safety study (NCT02721069) evaluated long-term safety of diazepam nasal spray (Valtoco) in patients with epilepsy and frequent seizure clusters." | 5.41 | Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy. ( Biton, V; Carrazana, E; Cascino, GD; Desai, J; Dlugos, D; Hogan, RE; Liow, K; Mauney, W; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D; Vazquez, B; Wheless, JW, 2021) |
| "Further, in both cases, auditory agnosia was associated with sleep-activated electroencephalographic (EEG) epileptiform activity, consistent with Landau-Kleffner syndrome." | 5.40 | Episodic epileptic verbal auditory agnosia in Landau Kleffner syndrome treated with combination diazepam and corticosteroids. ( Bojko, A; Devinsky, O; Goldberg, R; Miles, D; Riviello, J, 2014) |
| "Lacosamide (Vimpat) is a newly licensed novel antiepileptic drug." | 5.36 | Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. ( Eggers, C; Hofer, T; Resch, R; Tilz, C, 2010) |
| "To assess pharmacokinetics and safety of diazepam nasal spray (NRL-1; VALTOCO®) in pediatric and adult patients with epilepsy in seizure and nonseizure states." | 5.34 | Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study. ( Carrazana, E; Hogan, RE; Klein, P; Miller, I; Rabinowicz, AL; Segal, EB; Sperling, MR; Tarquinio, D, 2020) |
| "In PTZ-induced epileptic seizures, the i." | 5.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "In this phase III, randomized, double‐blind, parallel‐group, placebo‐controlled, multicenter study, subjects with epilepsy on a stable antiepileptic drug regimen who required intermittent medical intervention to control ARS were randomized 1:1 to the placebo AI or the diazepam AI group." | 5.17 | A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures. ( Abou-Khalil, B; Goli, V; Pixton, GC; Rogin, J; Roland, CL; Sherman, NA; Shukla, RB; Sommerville, K; Wheless, J; Wolter, KD, 2013) |
| "To compare intranasal midazolam, using a Mucosal Atomization Device (IN-MMAD), with rectal diazepam (RD) for the home treatment of seizures in children with epilepsy." | 5.14 | Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy. ( Adelgais, K; Dudley, N; Filloux, F; Firth, S; Greenberg, R; Healy, A; Holsti, M; Olsen, C; Schunk, J, 2010) |
| "The purpose of these investigations was to determine from combined data the response to rectal diazepam (DZP) gel (Diastat [Athena Neurosciences, South San Francisco, CA]) in home treatment of children with episodes of acute repetitive seizures (ARS)." | 5.09 | Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group. ( Cereghino, JJ; Cloyd, JC; Kriel, RL; Mitchell, WG; Pellock, JM; Rosman, NP, 1999) |
| "To assess safety of diazepam rectal gel (DZPRG) for control of acute seizures in epilepsy patients and to evaluate tolerance with repeated use of DZPRG at intervals of > or =5 days." | 5.09 | An open-label study of repeated use of diazepam rectal gel (Diastat) for episodes of acute breakthrough seizures and clusters: safety, efficacy, and tolerance. North American Diastat Group. ( Cereghino, JJ; Conry, JA; Crumrine, PK; Groves, L; Kriel, RL; Mitchell, WG; Rosenfeld, WE, 1999) |
| "Lorazepam was compared with diazepam for the treatment of acute convulsions and status epilepticus in 102 children in a prospective, open, 'odd and even dates' trial." | 5.08 | Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. ( Appleton, R; Choonara, I; Molyneux, E; Robson, J; Sweeney, A, 1995) |
| "Lamotrigine, a novel anticonvulsant, has been evaluated in patients with epilepsy using the method of interictal EEG spike counting." | 5.06 | The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy. ( Jawad, S; Oxley, J; Richens, A; Yuen, WC, 1986) |
| "Rectal administration of several different preparations of diazepam to a group of adult volunteer patients with epilepsy produced variable rates of absorption." | 5.05 | Absorption of diazepam from the rectum and its effect on interictal spikes in the EEG. ( Dhillon, S; Milligan, N; Oxley, J; Richens, A, 1982) |
| "Diazepam rectal gel (Diastat) is the only medication approved by the US FDA for the management of selected, refractory patients with epilepsy, on stable regimens of antiepilepsy drugs, who require intermittent use of diazepam to control bouts of increased seizure activity." | 4.82 | Safety of Diastat, a rectal gel formulation of diazepam for acute seizure treatment. ( Pellock, JM, 2004) |
| " Intermittent diazepam prophylaxis at times of fever may or may not reduce the recurrence rate significantly, but there is no data to suggest that it improves the long-term outcome, as compared with short-term seizure control, in terms of IQ, cognition, academic progress, motor control, and subsequent epilepsy." | 4.81 | [Febrile convulsions, Treatment and prognosis]. ( Knudsen, FU, 2001) |
| " Clonazepam, chlorazepate, nitrazepam and clobazam are also prescribed as chronic treatment of various forms of epilepsy." | 4.76 | [Benzodiazepines in the treatment of epilepsy]. ( Loiseau, P, 1983) |
| "To investigate the effects of different doses of esculetin on epileptiform activity, behavioral seizures, memory impairment, and cortical and hippocampal NF-κB, as a mediator of pro-inflammatory gene induction, and pro-inflammatory cytokines in penicillin- and pentylenetetrazole(PTZ)-induced seizure models in rats." | 4.31 | Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats. ( Ankarali, H; Baranoglu Kilinc, Y; Danis, A; Hanci, F; Kilinc, E; Torun, IE, 2023) |
| " We aim to test the effect of combining the therapeutic action of tSMS and diazepam, a drug used to treat status epilepticus." | 4.31 | Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model. ( Cudeiro, J; de Labra, C; Rivadulla, C, 2023) |
| "We gained insights into NfL levels during the various phases of the intrahippocampal kainic acid mouse model of temporal lobe epilepsy-namely, the status epilepticus (SE) and the chronic phase with spontaneous seizures." | 4.31 | Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy? ( Barbé, K; Bjerke, M; Custers, ML; Kaltenböck, L; Smolders, I; Van Eeckhaut, A; Vande Vyver, M, 2023) |
| "Patients prescribed sublingual lorazepam solution at the Johns Hopkins Epilepsy Center for acute seizure treatment during a 5-year period (2012-2017) were screened." | 4.31 | Sublingual lorazepam as rescue therapy for seizure emergencies in adults. ( Krauss, GL; Lelis, IR, 2023) |
| " In vivo, C57BL/6 mice that received intrahippocampal WNK463 experienced delayed onset of kainic acid-induced status epilepticus, less epileptiform EEG activity, and did not develop pharmaco-resistance to diazepam." | 4.12 | Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus. ( Abiraman, K; Brandon, NJ; Deeb, TZ; Lee, KL; Lucaj, C; Maguire, J; Moss, SJ; Ollerhead, TA, 2022) |
| "The aim of this study was to review out-of-hospital use of intranasal diazepam and midazolam for treatment of acute repetitive seizures (ARS) at a typical adult epilepsy center." | 4.12 | Use of new intranasal benzodiazepines at a typical adult epilepsy center. ( Benbadis, SR; Li, C, 2022) |
| " The present study was designed to investigate the effect of acute and chronic administration of thiamine alone and in combination with sub-effective dose of diazepam on pentylenetetrazole (PTZ)-induced tonic-clonic seizures in mice." | 3.91 | Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice. ( Abed, A; Alinejad, M; Banafshe, HR; Heydari, A; Mesdaghinia, A, 2019) |
| " The objective of this study was to evaluate the effect of non-steroidal anti-inflammatory diclofenac sodium on the severity of seizures and levels of pro-inflammatory interleukins in animals with kindling model induced by PTZ." | 3.83 | Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model. ( Coitinho, AS; Glassmann, D; Gomez, R; Marafon, P; Pereira, P; Vieira, V, 2016) |
| " This new method documented that seizures in the zebrafish EAST model were ameliorated by pentobarbitone, but not diazepam, validating its usefulness." | 3.79 | Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings. ( Bockenhauer, D; Kleta, R; Mahmood, F; Russell, C; Stanescu, HC; Zdebik, AA, 2013) |
| " Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P < 0." | 3.79 | Hypoxia markers are expressed in interneurons exposed to recurrent seizures. ( Biagini, G; Gualtieri, F; Longo, D; Marinelli, C; Meletti, S; Nichelli, PF; Pugnaghi, M, 2013) |
| "Catamenial epilepsy is caused by fluctuations in progesterone-derived GABA(A) receptor-modulating anticonvulsant neurosteroids, such as allopregnanolone, that play a significant role in the pathophysiology of epilepsy." | 3.78 | A mouse kindling model of perimenstrual catamenial epilepsy. ( Gangisetty, O; Gould, J; Reddy, DS, 2012) |
| " The endocannabinoid system is known to modulate seizure activity in several in vivo and in vitro models, and CB(1) -receptor activation is anticonvulsant in the rat pilocarpine model of acquired epilepsy (AE)." | 3.78 | Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain. ( Blair, RE; DeLorenzo, RJ; Nguyen, PT; Sayers, KW; Sim-Selley, LJ, 2012) |
| "Rectal diazepam solution, administered by capable caregivers, is as effective and safe as rectal administration of IVD for children with intractable epilepsy." | 3.77 | Rectal diazepam solution is as good as rectal administration of intravenous diazepam in the first-aid cessation of seizures in children with intractable epilepsy. ( Chen, YI; Chiang, LM; Chou, ML; Deng, ST; Hung, PC; Lin, KL; Shen, HH; Tseng, CH; Wang, HS, 2011) |
| "Acute application of human ASCs-E before SE led to earlier attenuation of seizure spike activities after treatment with diazepam, reduction of BBB leakage, and inhibition of the development of epilepsy." | 3.77 | A cell-free extract from human adipose stem cells protects mice against epilepsy. ( Ban, JJ; Chu, K; Jeon, D; Jung, KH; Kang, KM; Kim, M; Kim, S; Lee, SK; Lee, ST; Roh, JK; Seo, JS; Won, CH, 2011) |
| "Rectal diazepam is established as a standard rescue or emergency treatment for seizure or status epilepticus; however, the rectal route of administration has not been universally accepted." | 3.76 | A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations. ( Bertram, E; de Haan, GJ; Doelman, G; Edelbroek, P; van der Geest, P, 2010) |
| "The DNS II acetone fraction of Delphinium nordhagenii has exhibited the anticonvulsant actions by preventing the seizures against PTZ- and picrotoxin-induced seizure as well as 100% seizure protection in MES test." | 3.76 | Anticonvulsant activity of DNS II fraction in the acute seizure models. ( Ahmad, M; Raza, ML; Shaheen, F; Simjee, SU; Zeeshan, M, 2010) |
| " The present study was designed to investigate the outcomes of diazepam plus pentobarbital administered at 30 min, 1, 2 or 6h after the beginning of TsTx-induced SE, on the development of spontaneous recurrent motor seizures (SRMSs), mossy fibre sprouting and hippocampal neurodegeneration in rats." | 3.75 | Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy. ( Lebrun, I; Luongo, R; Oliveira, DA; Sandoval, MR, 2009) |
| "This study was conducted to identify how often parents of children with epilepsy encounter barriers to the use of diazepam rectal gel in day care or school settings and how these barriers affect the child and family." | 3.74 | Acceptance of the use of diazepam rectal gel in school and day care settings. ( Karn, M; Paolicchi, J; Terry, D, 2007) |
| "During her first pregnancy, a 37-year-old woman with idiopathic generalised epilepsy that was adequately controlled with lamotrigine experienced a series of epileptic seizures following an elective caesarean section." | 3.73 | [Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy]. ( Bloem, BR; Renier, WO; Voermans, NC; Zwarts, MJ, 2005) |
| "To investigate changes in free benzodiazepine receptor density in response to repeated, long-term administration of diazepam in epilepsy, we assessed 125I-iomazenil (125I-IMZ) binding in a mouse model." | 3.73 | Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse. ( Fukumitsu, N; Mori, Y; Ogi, S; Uchiyama, M, 2006) |
| " Although epilepsy-like symptoms occurred at the first course of VIP therapy, these symptoms immediately improved by diazepam administration." | 3.72 | [A case of advanced rhabdomyosarcoma of the spermatic cord who occurred epilepsy-like symptoms, but was completely responded to chemotherapy]. ( Kobayashi, M; Suzuki, K; Tokue, A, 2004) |
| "Perimenstrual catamenial epilepsy may in part be due to withdrawal of the endogenous progesterone-derived neurosteroid allopregnanolone that potentiates gamma-aminobutyric acidA (GABA(A)) receptor-mediated inhibition." | 3.71 | Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2001) |
| "A pilot study involved two primary school children with unstable epilepsy, whose medical treatment included intermittent rectal Diazepam." | 3.70 | Who cares for students with epilepsy in mainstream education? ( Lanfear, JH; Rashid, C, 1998) |
| "The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs." | 3.70 | Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. ( Gobert, J; Klitgaard, H; Matagne, A; Wülfert, E, 1998) |
| "The rectal administration of diazepam (DZP) has provided a safer existence to many epilepsy patients and their carers, when prolonged or serial seizures are present." | 3.70 | Rectal diazepam: pitfalls of excessive use in refractory epilepsy. ( Aamo, T; Brodtkorb, E; Henriksen, O; Lossius, R, 1999) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 3.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| "The development of tolerance to the anticonvulsant effects of clonazepam, clobazam, and diazepam were studied in genetically epilepsy-prone rats following intraperitoneal (IP) or oral administration." | 3.69 | Tolerance to anticonvulsant effects of some benzodiazepines in genetically epilepsy prone rats. ( Aguglia, U; de Sarro, A; De Sarro, G; Di Paola, ED, 1996) |
| "Following pilocarpine-induced status epilepticus, rats become chronically epileptic showing 2-3 spontaneous recurrent seizures per week." | 3.69 | Blockade of spreading depression in chronic epileptic rats: reversion by diazepam. ( Cavalheiro, EA; Guedes, RC, 1997) |
| "We examined the anticonvulsant effects of BW1003C87 (5-(2,3,5-trichlorophenyl)-2,4-diaminopyrimidine ethane sulphonic acid), which is structurally related to the new antiepileptic drug, lamotrigine, and compared its effects to those of the conventional antiepileptic drugs, phenytoin and carbamazopine, using the rat amygdala-kindling model of epilepsy." | 3.69 | BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy. ( Morimoto, K; Sato, H; Sato, K; Sato, S; Yamada, N, 1997) |
| "Sound-induced seizures in genetically epilepsy-prone rats were used to compare the anticonvulsant effect of phenytoin and diazepam with compounds which decrease glutamatergic neurotransmission including excitatory amino acid antagonists acting at N-methyl-D-aspartate (NMDA) receptors: D(-)CPPene, CGP 37849 and MK 801 or at the glycine/NMDA site: ACPC (1-aminocyclopropane-dicarboxylic acid) (partial agonist) or non-NMDA receptors: NBQX (2,3-dihydroxy-6-nitro-7-sulfamoylbenzo[f]-quinoxaline." | 3.68 | Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat. ( al-Zubaidy, ZA; Chapman, AG; Meldrum, BS; Smith, SE, 1993) |
| "Diazepam-induced EEG changes were analyzed both visually and by computer in epilepsy for localization of epileptogenic lesion." | 3.68 | [Visual and computer evaluation of diazepam-induced EEG changes in epilepsy for localization of epileptogenic lesion]. ( Huang, Z, 1992) |
| "Rapid diazepam (DZP) introduction was investigated in 24 children with different types of cryptogenic or symptomatic generalized epilepsy and EEG epileptic "status" with EEG and pharmacologic monitoring." | 3.68 | Rapid diazepam introduction (venous or rectal) in childhood epilepsy: taxonomic and therapeutic considerations. ( Baglietto, MG; De Negri, M; Gaggero, R; Pallecchi, A; Pessagno, A; Veneselli, E, 1991) |
| "The mechanisms underlying tolerance to benzodiazepines were investigated by injecting diazepam (5 mg/kg) twice daily for 23 days in WAG/Rij rats (an animal model for non-convulsive absence epilepsy)." | 3.68 | Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam. ( Coenen, AM; Nutt, DJ; Peeters, BW; Titulaer, MN; Van Rijn, CM; Vossen, JM, 1990) |
| "We have investigated the influence of central noradrenergic and dopaminergic systems on the susceptibility of rats to seizures in the kainic acid (KA)-model of epilepsy." | 3.67 | Kainic acid-induced seizures: potentiation by alpha-methyl-p-tyrosine. ( Baran, H; Hornykiewicz, O; Hörtnagl, H, 1989) |
| "Three drugs which increase GABA-mediated inhibitory neurotransmission in the brain, namely the GABA degradation inhibitors aminooxyacetic acid (AOAA) and gamma-acetylenic GABA (GAG), and the GABA receptor agonist THIP (gaboxadol), were administered to epilepsy-prone gerbils via subcutaneously implanted osmotic minipumps for 2 weeks." | 3.67 | Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. ( Löscher, W, 1986) |
| "We evaluated the EEG reaction to an intravenous injection of diazepam as an additional tool in difficult localization problems in epilepsy." | 3.66 | Correlations between EEG changes induced by diazepam and the localization of epileptic spikes and seizures. ( Gloor, P; Gotman, J; Olivier, A; Quesney, LF, 1982) |
| "Repeated seizures, whether induced by kindling or electroshock, caused a long-lasting (at least 24 hr) increase of [3H]diazepam binding in hippocampal membranes of Sprague-Dawley rats." | 3.66 | Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors. ( McNamara, JO; Patrone, V; Peper, AM, 1980) |
| "The absorption of diazepam after rectal administration was studied in children with epilepsy." | 3.66 | Rectal absorption of diazepam in epileptic children. ( Dhillon, S; Ngwane, E; Richens, A, 1982) |
| "Thirty cases of intractable epilepsy in children were investigated to observe the correlation between the suppression of seizure discharges to intravenous diazepam and the type of seizure or effects of subsequent therapy." | 3.66 | Diagnostic and prognostic significance of electroencephalography with intravenous diazepam in epilepsy. ( Goya, N; Kurokawa, T; Mitsudome, A; Shibata, R; Takashima, S; Yokota, K, 1979) |
| " The treatment of status epilepticus with intravenous phenytoin is effective." | 3.66 | Epilepsy and pregnancy. ( Bruni, J; Willmore, LJ, 1979) |
| "In a prospective study 44 children, aged 6 months to 5 years, admitted to hospital with febrile convulsions or epilepsy, were treated with diazepam in solution administered rectally during 59 generalised attacks." | 3.66 | Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children. ( Knudsen, FU, 1979) |
| "The therapeutics results with the use of different drugs (diazepam, nitrazepam, clonazepam, diphenylhydantoin, barbiturates--phenobarbital and primidone--, sodium dipropylacetate and ACTH) in twenty-nine patients with Lennox--Gastaut syndrome are carefully analysed." | 3.65 | [Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome]. ( Lison, MP; Speciali, GG, 1977) |
| " In the Hungarian Congenital Malformation Register use of the anticonvulsants diazepam and phenobarbiturates during pregnancy was determined in infants delivered with cleft lip with or without cleft palate, posterior cleft palate and, as a control, anencephaly and spina bifida." | 3.65 | A teratological evaluation of anticonvulsant drugs. ( Czeizel, E; Lakos, P, 1977) |
| " Concomitant CBD use was recorded, and treatment-emergent adverse events (TEAEs) were collected." | 3.30 | Concomitant cannabidiol does not impact safety and effectiveness of diazepam nasal spray for seizure clusters: Post hoc analysis of a phase 3 safety study. ( Carrazana, E; Misra, SN; Peters, JM; Puri, V; Rabinowicz, AL; Segal, E, 2023) |
| " Across groups, treatment-emergent adverse event rates ranged from 66." | 3.30 | Safety of Diazepam Nasal Spray in Pediatric Patients With Developmental Epileptic Encephalopathies: Results From a Long-term Phase 3 Safety Study. ( Carrazana, E; Misra, SN; Rabinowicz, AL; Segal, EB; Tarquinio, D; Wheless, JW, 2023) |
| " Safety assessments included treatment-emergent adverse events (TEAEs)." | 3.11 | Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study. ( Carrazana, E; Desai, J; Dlugos, D; Rabinowicz, AL; Tarquinio, D; Wheless, JW, 2022) |
| "Epilepsy is a chronic disease of the central nervous system characterized by recurrent epileptic seizures." | 3.01 | Second Generation of Antiepileptic Drugs and Oxidative Stress. ( Czuczwar, SJ; Kamieniak, M; Kośmider, K; Miziak, B, 2023) |
| "Patients with epilepsy can experience seizure clusters (acute repetitive seizures), defined as intermittent, stereotypic episodes of frequent seizure activity that are distinct from typical seizure patterns." | 3.01 | Overcoming barriers to the management of seizure clusters: ease of use and time to administration of rescue medications. ( Bougher, G; Dean, P; Desai, J; Dewar, S; Misra, SN; O'Hara, K, 2023) |
| " Adverse events (AEs) and usability assessments were recorded after the first dose, then every 3 months." | 2.94 | Safety and tolerability associated with chronic intermittent use of diazepam buccal film in adult, adolescent, and pediatric patients with epilepsy. ( Buan, C; Gelfand, MA; Heller, AH; Seinfeld, S; Slatko, G, 2020) |
| "Although generalized convulsive status epilepticus (GCSE) is a life-threatening emergency, evidence-based data to guide initial drug treatment choices are lacking in the Chinese population." | 2.82 | Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China. ( Chen, W; Chun, B; Gao, D; Jiang, M; Liu, G; Ren, G; Su, Y; Tian, F; Ye, H; Zhang, Y, 2016) |
| "No patient in the VPA group developed respiratory depression, hypotension, or hepatic dysfunction, whereas in the DZP group, 5." | 2.76 | Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study. ( Chen, WB; Fan, CQ; Gao, R; Ren, Y; Su, YY; Wang, L; Zhang, YZ; Zhao, JW, 2011) |
| "Diazepam treatment was superior to placebo with regard to the outcome variables related to efficacy: reduced seizure frequency (P<0." | 2.69 | A comparison of rectal diazepam gel and placebo for acute repetitive seizures. ( Bell, WE; Bergen, DC; Cloyd, JC; Conry, JA; Dreifuss, FE; Kuzniecky, RI; Lo, WD; Matsuo, F; Pellock, JM; Rosman, NP; Sharp, GB, 1998) |
| "A cohort of 289 children with febrile convulsions who had been randomised in early childhood to either intermittent prophylaxis (diazepam at fever) or no prophylaxis (diazepam at seizures) was followed up 12 years later." | 2.68 | Long term outcome of prophylaxis for febrile convulsions. ( Andersen, R; Andresen, J; Knudsen, FU; Paerregaard, A, 1996) |
| "When flumazenil (3 mg) was administered immediately after intravenous diazepam (10 mg), the reduction in interictal epileptic activity was not significantly different from that produced by diazepam alone." | 2.67 | The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study. ( Hart, YM; Meinardi, H; Nutt, DJ; Sander, JW; Shorvon, SD, 1991) |
| "Diazepam was administered rectally as a new experimental suppository formulation immediately after a seizure and was highly effective in preventing recurrent fits within a 24 h observation period (p less than 0." | 2.65 | A clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients. ( Dhillon, S; Griffiths, A; Milligan, NM; Oxley, J; Richens, A, 1984) |
| " Currently, Diazepam rectal gel is the only approved therapy for the outpatient management of seizures, but there is a growing need for alternative medications for terminating seizures that may be not only safe and effective but also socially acceptable." | 2.52 | Safety and efficacy of diazepam autoinjector for the management of epilepsy. ( Milioni, M; Verrotti, A; Zaccara, G, 2015) |
| "Febrile seizures are most common seizures in childhood (2-4%)." | 2.42 | [Febrile seizures--an update]. ( Püst, B, 2004) |
| "However, there is no evidence that treatment of simple febrile seizures can prevent the rare cases of later epilepsy, and many children with complex febrile seizures have a benign long-term outcome, even without treatment." | 2.41 | Febrile seizures: treatment and prognosis. ( Knudsen, FU, 2000) |
| "Epilepsy affects 1." | 2.41 | New antiepileptic drugs and preparations. ( Jagoda, A; Yoon, Y, 2000) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| "Fosphenytoin has recently been approved as a substitute for parenteral phenytoin." | 2.40 | New drug therapy for acute seizure management. ( Morton, LD; Pellock, JM; Rizkallah, E, 1997) |
| "Successful treatment of seizure disorders in small animals requires proper patient assessment, understanding the principles of antiepileptic drug (AED) therapy, designing a strategy for pharmacotherapy, and plans for emergency treatment." | 2.40 | Antiepileptic drug therapy. ( Podell, M, 1998) |
| "Sequelae and risk for recurrence of SE are primarily related to the underlying cause." | 2.39 | Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment. ( Mitchell, WG, 1996) |
| " However, their chronic use may be associated with serious sedative-hypnotic effects that interfere with cognitive function and behavior." | 2.37 | Use of barbiturates and benzodiazepines in treatment of epilepsy. ( Vining, EP, 1986) |
| "Epilepsy is a common neurological disorder which affects 50 million people worldwide." | 1.72 | Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio). ( Aguiar, GPS; Lima-Rezende, CA; Müller, LG; Oliveira, JV; Pedroso, J; Piato, A; Schneider, SE; Siebel, AM, 2022) |
| "Beyond effectiveness for aborting seizure clusters, no data exist on how intermittent rescue therapy may impact the long-term natural course of seizure clusters." | 1.72 | Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters. ( Carrazana, E; Davis, C; Misra, SN; Peters, JM; Rabinowicz, AL; Rao, VR; Sperling, MR, 2022) |
| " Using an animal model of chemically-induced epileptic seizures, we tested exercise alone as non-pharmacological therapy, and exercise combined with an anti-inflammatory drug." | 1.72 | Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures. ( Barbosa, BB; Coitinho, AS; de Lima Rosa, G; Domingues, AM; Guzzo, EFM; Nunes, SEB; Padilha, RB; Siqueira, IR, 2022) |
| "camptopus in acute models of epileptic seizures in Wistar rats." | 1.62 | Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats. ( Chouna, R; Dongmo, AK; Fokoua, AR; Kaptué Wuyt, A; Ndjenda, MK; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD, 2021) |
| "Status epilepticus is defined as a state of unrelenting seizure activity." | 1.51 | Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus. ( Akerman, CJ; Burman, RJ; Calin, A; Codadu, NK; Katz, AA; Lee, JH; Newey, SE; Parrish, RR; Raimondo, JV; Selfe, JS; Trevelyan, AJ; van den Berg, M; Wilmshurst, JM; Wright, R, 2019) |
| ", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "To determine the prognostic factors for encephalopathy with bright tree appearance (BTA) in the acute phase through retrospective case evaluation." | 1.42 | Prognostic factors for acute encephalopathy with bright tree appearance. ( Azuma, J; Iwatani, Y; Kagitani-Shimono, K; Kitai, Y; Nabatame, S; Nagai, T; Nakano, S; Okinaga, T; Ozono, K; Tominaga, K; Yamamoto, T, 2015) |
| "We report one Chinese patient with neurosyphilis exhibiting periodic lateralized epileptiform discharges (PLEDs) in the electroencephalogram (EEG)." | 1.40 | A patient with progressive cognitive decline and periodic abnormal waves in EEG: PLEDs of neurosyphilis or PSDs of Creutzfeldt-Jakob disease? ( Chu, F; Cui, L; Lv, Y; Meng, H; Wang, Z, 2014) |
| "Further, in both cases, auditory agnosia was associated with sleep-activated electroencephalographic (EEG) epileptiform activity, consistent with Landau-Kleffner syndrome." | 1.40 | Episodic epileptic verbal auditory agnosia in Landau Kleffner syndrome treated with combination diazepam and corticosteroids. ( Bojko, A; Devinsky, O; Goldberg, R; Miles, D; Riviello, J, 2014) |
| "A device capable of detecting seizures and alerting caregivers would be a major advance for epilepsy management, and could be used to guide early intervention and prevent seizure-related injuries." | 1.39 | Feasibility study of a caregiver seizure alert system in canine epilepsy. ( Cloyd, JC; Coles, LD; Higgins, J; Leyde, K; Litt, B; Mavoori, J; Michael, B; Patterson, EE; Sheffield, WD; Vite, C; Worrell, GA, 2013) |
| "Pretreatment with diazepam (DZP) significantly attenuated seizure severity." | 1.39 | Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization. ( Baggio, S; Battastini, AM; Calcagnotto, ME; Campos, MM; de Oliveira, DL; Dias, RD; Leite, CE; Moro, L; Mussulini, BH; Rico, EP; Rosemberg, DB; Souza, TM; Zenki, KC, 2013) |
| "Valproic acid was less effective in OHSCs than in the kindled seizure tests, and diazepam was more (generalized seizures) or less (focal seizures and afterdischarge durations) effective in this animal model than in OHSCs." | 1.38 | Primary afterdischarge in organotypic hippocampal slice cultures: effects of standard antiepileptic drugs. ( Albus, K; Heinemann, U; Wahab, A, 2012) |
| "The EEGs performed during migraine-free period, on the contrary, showed very rare and mild subclinical ictal discharges." | 1.37 | Migraine triggered by epileptic discharges in a Rasmussen's encephalitis patient after surgery. ( Ciofetta, G; Fusco, L; Longo, D; Specchio, N; Trivisano, M; Vigevano, F, 2011) |
| "Epilepsy affects 0." | 1.37 | Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats. ( Cammarota, M; DaCosta, JC; Greggio, S; Machado, DC; Marinowic, DR; Venturin, GT; Zanirati, G, 2011) |
| "Epilepsy is a common and refractory neurological disorder, but the neuronal regulatory mechanisms of epileptogenesis remain largely unclear." | 1.37 | Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons. ( Hu, XL; Liu, YY; Mei, L; Tan, GH; Xiong, ZQ; Yin, DM, 2011) |
| "Lacosamide (Vimpat) is a newly licensed novel antiepileptic drug." | 1.36 | Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. ( Eggers, C; Hofer, T; Resch, R; Tilz, C, 2010) |
| "PPhenytoin was 10-fold less (1." | 1.34 | Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs. ( Cucullo, L; Hossain, M; Janigro, D; Manders, T; Marchi, N; Rapp, E, 2007) |
| "Upon treatment with diazepam and haloperidol, the psychosis subsided within three days." | 1.34 | [Postictal paranoid-hallucinatory psychosis in cryptogenic epilepsy]. ( Baum, P; Hermann, W; Kopf, A; Wagner, A, 2007) |
| "In PTZ-induced epileptic seizures, the i." | 1.33 | Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. ( Hosseinzadeh, H; Mansouri, MT; Nassiri-Asl, M; Parvardeh, S, 2005) |
| "The authors reviewed respiratory adverse events and deaths spontaneously reported to Xcel Pharmaceuticals associated with diazepam rectal gel." | 1.33 | Respiratory adverse events associated with diazepam rectal gel. ( Pellock, JM; Shinnar, S, 2005) |
| "Reported are three patients with ictal monoparesis of an arm." | 1.33 | Ictal monoparesis associated with lesions in the primary somatosensory area. ( Aoki, T; Hanakawa, T; Hitomi, T; Ikeda, A; Matsumoto, R; Miki, Y; Shibasaki, H; Shimohama, S; Tomimoto, H, 2005) |
| "Phenytoin is a known inducer of drugs metabolized by CYP2C, CYP2D, and CYP3A, but its own metabolism may be altered by drugs influencing CYP2C9 or CYP2C19, such as diazepam." | 1.32 | Phenytoin-diazepam interaction. ( Murphy, A; Wilbur, K, 2003) |
| " Marked differences in drug sensitivity were observed between models based on single and chronic administration of PTZ showing that the two sets of models are fundamentally different." | 1.32 | Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice. ( Hansen, SL; Sánchez, C; Sperling, BB, 2004) |
| "A partial but significant inhibition of convulsions was found in these animals." | 1.31 | Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam. ( Jayakumar, AR; Vanaja, P, 2001) |
| "Diazepam (DZP) was intraperitoneally injected (0." | 1.30 | Diazepam--its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss. ( Becker, A; Grecksch, GA; Tiedge, A, 1997) |
| "Patients with epileptic and nonepileptic seizures are commonly encountered in clinical practice, and they can pose a difficult diagnostic problem." | 1.30 | Cerebral perfusion SPECT imaging in epileptic and nonepileptic seizures. ( Blend, MJ; de León, OA; Gaviria, M; Jobe, TH; Lin, Q; Sychra, JJ, 1997) |
| "Two pharmacoeconomic studies on the treatment of acute seizures have been conducted." | 1.30 | Pharmacoeconomic considerations in treatment options for acute seizures. ( Graves, N, 1998) |
| " Similarly, there was a reduction in maximal plasma concentration, bioavailability (F), mean residence time, and time to target and peak concentrations in the postphenobarbital p." | 1.30 | Chronic phenobarbital therapy reduces plasma benzodiazepine concentrations after intravenous and rectal administration of diazepam in the dog. ( Podell, M; Sams, RA; Wagner, SO, 1998) |
| "Simple febrile seizures that occur in children ages 6 months to 5 years are common events with few adverse outcomes." | 1.30 | Technical report: treatment of the child with simple febrile seizures. ( Baumann, RJ, 1999) |
| "Seizures are a frequent problem confronting EMS personnel." | 1.30 | Prehospital management of the seizure patient. ( Nicholl, JS, 1999) |
| "In diazepam chronically treated mice, it attenuated diazepam tolerance (provoked by later acute administration of diazepam together with convulsant) and postponed physical dependence/withdrawal effects (provoked by later administration of isoniazid)." | 1.30 | The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam. ( Anic, T; Aralica, G; Dodig, G; Duplancie, B; Jelovac, N; Marovic, A; Mise, S; Perovic, D; Petek, M; Pigac, B; Prkacin, I; Rucman, R; Sebecic, B; Seiwerth, S; Sikiric, P; Slobodnjak, Z; Stancic-Rokotov, D; Turkovic, B; Ziger, T; Zoricic, I, 1999) |
| "We present the case of a patient that after chronic use of anticonvulsant drugs without proven epilepsy, developed Dupuytren's and Ledderhose's diseases." | 1.30 | [Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report]. ( Coral, P; Correa Neto, Y; Nóvak, EM; Teive, HA; Werneck, LC; Zanatta, A, 1999) |
| "Diazepam was the first line treatment in 98 episodes, chlormethiazole and phenytoin were used in 27 and 18 episodes, respectively." | 1.29 | Status epilepticus: management and outcome of 107 episodes. ( Martin, PJ; Millac, PA, 1994) |
| "The latter 2 cases had been treated as epilepsy." | 1.29 | [Five cases of paroxysmal sleep disturbances]. ( Ikeno, T; Nagai, H, 1993) |
| "The combination of West syndrome (WS) and Down syndrome appears not to be coincidental." | 1.29 | Early clinical and EEG features of infantile spasms in Down syndrome. ( Cieuta, C; Dulac, O; Guerrini, R; Livet, MO; Plouin, P; Silva, ML, 1996) |
| "Electroencephalographic (EEG) seizures, grouped and isolated spikes, and significant increases of multineuronal activity (MUA) were elicited by fentanyl, 50 micrograms/kg iv, in these brain structures." | 1.29 | Effects of diazepam on fentanyl-induced epileptoid EEG activity and increase of multineuronal firing in limbic and mesencephalic brain structures. ( Antonio-Ocampo, A; Cervantes, M; Chávez-Carrillo, I; Contreras-Gómez, A; Ruelas, R, 1996) |
| " Newborns and premature infants can metabolize and eliminate diazepam, although the parent drug has a longer half-life and decreased rate of biotransformation to its primary metabolites than in older children and adults." | 1.27 | Pharmacokinetics of benzodiazepines and psychostimulants in children. ( Coffey, B; Greenblatt, DJ; Shader, RI, 1983) |
| "Diazepam was injected by rectal route as an anticonvulsant, using a dose of 0." | 1.27 | Rectal diazepam: a clinical and EEG study after a single dose in children. ( Carboni, C; Franzoni, E; Lambertini, A, 1983) |
| "Carbamazepine, in contrast, has rather a stimulatory action." | 1.27 | [Modification of psychophysical performance of the human by anticonvulsants]. ( Meyer, FP; Walther, H, 1987) |
| "Midazolam is a water soluble 1,4 benzodiazepine which is suitable for intramuscular administration." | 1.27 | A pharmacodynamic evaluation of midazolam as an antiepileptic compound. ( Jawad, S; Oxley, J; Richens, A; Wilson, J, 1986) |
| " The elimination half-life was significantly shorter and the plasma clearance significantly higher in the patients than in the normal volunteers." | 1.26 | Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration. ( Dhillon, S; Richens, A, 1981) |
| "A Consensus Development Conference on Febrile Seizures was held at the National Institutes of Health in USA in May 1980." | 1.26 | ["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis]. ( Helwig, H; Staudt, F, 1982) |
| " The pathogenesis points to a multifactorial occurrence caused by the coincidence of an increased dosage of the contrast media, too bed rest time, rising of the contrast media in the spinal cord zone and disturbed liquor fluid circulation and contrast media resorption." | 1.26 | [Side reaction after lumbar myelography with dimer-x (author's transl)]. ( Egli, M; Walker, N; Wellauer, J, 1976) |
| "Recurrent acute respiratory failure in an epileptic subject is described." | 1.25 | Respiratory failure as a seizure phenomenon. A case report. ( Malatinský, J; Procházka, M; Sámel, M, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 305 (57.55) | 18.7374 |
| 1990's | 82 (15.47) | 18.2507 |
| 2000's | 58 (10.94) | 29.6817 |
| 2010's | 53 (10.00) | 24.3611 |
| 2020's | 32 (6.04) | 2.80 |
| Authors | Studies |
|---|---|
| Meinke, PT | 1 |
| Shoop, WL | 1 |
| Michael, BF | 1 |
| Blizzard, TA | 1 |
| Dawson, GR | 1 |
| Fisher, MH | 1 |
| Mrozik, H | 1 |
| Waszkielewicz, AM | 1 |
| Gunia-Krzyżak, A | 1 |
| Powroźnik, B | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Walczak, M | 1 |
| Bednarski, M | 1 |
| Żesławska, E | 1 |
| Nitek, W | 1 |
| Marona, H | 1 |
| Lee, KL | 1 |
| Abiraman, K | 1 |
| Lucaj, C | 1 |
| Ollerhead, TA | 1 |
| Brandon, NJ | 1 |
| Deeb, TZ | 1 |
| Maguire, J | 1 |
| Moss, SJ | 1 |
| Sharma, S | 1 |
| Detyniecki, K | 1 |
| Tarquinio, D | 7 |
| Dlugos, D | 4 |
| Wheless, JW | 6 |
| Desai, J | 6 |
| Carrazana, E | 10 |
| Rabinowicz, AL | 10 |
| Pedroso, J | 1 |
| Schneider, SE | 1 |
| Lima-Rezende, CA | 1 |
| Aguiar, GPS | 1 |
| Müller, LG | 1 |
| Oliveira, JV | 1 |
| Piato, A | 1 |
| Siebel, AM | 1 |
| Li, C | 1 |
| Benbadis, SR | 1 |
| Misra, SN | 5 |
| Sperling, MR | 6 |
| Rao, VR | 1 |
| Peters, JM | 3 |
| Davis, C | 2 |
| de Lima Rosa, G | 1 |
| Guzzo, EFM | 1 |
| Nunes, SEB | 1 |
| Padilha, RB | 1 |
| Domingues, AM | 1 |
| Barbosa, BB | 1 |
| Siqueira, IR | 1 |
| Coitinho, AS | 2 |
| Danis, A | 1 |
| Baranoglu Kilinc, Y | 1 |
| Torun, IE | 1 |
| Hanci, F | 1 |
| Kilinc, E | 1 |
| Ankarali, H | 1 |
| de Labra, C | 1 |
| Cudeiro, J | 1 |
| Rivadulla, C | 1 |
| Salahinejad, A | 1 |
| Meuthen, D | 1 |
| Attaran, A | 1 |
| Chivers, DP | 1 |
| Ferrari, MCO | 1 |
| Li, J | 2 |
| Cui, Y | 1 |
| Li, H | 1 |
| Hou, X | 1 |
| Zhao, F | 1 |
| Zhao, Q | 1 |
| Zhao, J | 1 |
| Lin, P | 1 |
| Meyer, S | 1 |
| Langer, J | 1 |
| Poryo, M | 1 |
| Bay, JG | 1 |
| Wagenpfeil, S | 1 |
| Heinrich, B | 1 |
| Nunold, H | 1 |
| Strzelczyk, A | 1 |
| Ebrahimi-Fakhari, D | 1 |
| Kośmider, K | 1 |
| Kamieniak, M | 1 |
| Czuczwar, SJ | 1 |
| Miziak, B | 1 |
| Shi, J | 1 |
| Xin, H | 1 |
| Shao, Y | 1 |
| Dai, S | 1 |
| Tan, N | 1 |
| Li, Z | 1 |
| Fei, F | 1 |
| Wu, D | 1 |
| Wang, Y | 1 |
| Ping, Y | 1 |
| Chen, Z | 1 |
| O'Hara, K | 3 |
| Dewar, S | 1 |
| Bougher, G | 1 |
| Dean, P | 1 |
| Puri, V | 1 |
| Segal, E | 1 |
| Ramsay, RE | 1 |
| Becker, DA | 1 |
| Vazquez, B | 4 |
| Birnbaum, AK | 1 |
| Custers, ML | 1 |
| Vande Vyver, M | 1 |
| Kaltenböck, L | 1 |
| Barbé, K | 1 |
| Bjerke, M | 1 |
| Van Eeckhaut, A | 1 |
| Smolders, I | 1 |
| Lelis, IR | 1 |
| Krauss, GL | 1 |
| Lawal, OD | 1 |
| Meador, KJ | 1 |
| Hume, AL | 1 |
| Wen, X | 1 |
| Segal, EB | 5 |
| Burman, RJ | 1 |
| Selfe, JS | 1 |
| Lee, JH | 1 |
| van den Berg, M | 1 |
| Calin, A | 1 |
| Codadu, NK | 1 |
| Wright, R | 1 |
| Newey, SE | 1 |
| Parrish, RR | 1 |
| Katz, AA | 1 |
| Wilmshurst, JM | 1 |
| Akerman, CJ | 1 |
| Trevelyan, AJ | 1 |
| Raimondo, JV | 1 |
| Bai, YF | 1 |
| Chiu, M | 1 |
| Chan, ES | 1 |
| Axerio-Cilies, P | 1 |
| Lu, J | 1 |
| Huh, L | 1 |
| Connolly, MB | 1 |
| Guella, I | 1 |
| Farrer, MJ | 1 |
| Xu, ZD | 1 |
| Liu, L | 1 |
| Demos, M | 1 |
| Wang, YT | 1 |
| Le Coz, J | 1 |
| Chéron, G | 1 |
| Nabbout, R | 1 |
| Patteau, G | 1 |
| Heilbronner, C | 1 |
| Hubert, P | 1 |
| Renolleau, S | 1 |
| Oualha, M | 1 |
| Steudle, F | 1 |
| Rehman, S | 1 |
| Bampali, K | 1 |
| Simeone, X | 1 |
| Rona, Z | 1 |
| Hauser, E | 1 |
| Schmidt, WM | 1 |
| Scholze, P | 1 |
| Ernst, M | 1 |
| Hogan, RE | 5 |
| Klein, P | 1 |
| Miller, I | 4 |
| Seinfeld, S | 1 |
| Gelfand, MA | 1 |
| Heller, AH | 1 |
| Buan, C | 1 |
| Slatko, G | 1 |
| Fedak Romanowski, EM | 1 |
| McNamara, NA | 1 |
| Neil, EE | 1 |
| Gottlieb-Smith, R | 1 |
| Dang, LT | 1 |
| Fokoua, AR | 1 |
| Ndjenda, MK | 1 |
| Kaptué Wuyt, A | 1 |
| Tatsinkou Bomba, FD | 1 |
| Dongmo, AK | 1 |
| Chouna, R | 1 |
| Nkeng-Efouet, PA | 1 |
| Nguelefack, TB | 1 |
| Biton, V | 3 |
| Cascino, GD | 4 |
| Liow, K | 4 |
| Cook, DF | 1 |
| Mauney, W | 2 |
| Erfanparast, A | 2 |
| Tamaddonfard, E | 3 |
| Henareh-Chareh, F | 1 |
| Mesdaghinia, A | 1 |
| Alinejad, M | 1 |
| Abed, A | 1 |
| Heydari, A | 1 |
| Banafshe, HR | 1 |
| Nunley, S | 1 |
| Glynn, P | 1 |
| Rust, S | 1 |
| Vidaurre, J | 1 |
| Albert, DVF | 1 |
| Patel, AD | 1 |
| Vigevano, F | 2 |
| Kirkham, FJ | 1 |
| Wilken, B | 1 |
| Raspall-Chaure, M | 1 |
| Grebla, R | 1 |
| Lee, D | 2 |
| Werner-Kiechle, T | 1 |
| Lagae, L | 1 |
| Vengerovich, NG | 1 |
| Drachkova, IM | 1 |
| Yudin, MA | 1 |
| Bykov, VN | 1 |
| Sarana, AM | 1 |
| Awa, HD | 1 |
| Chelo, D | 1 |
| Kinkela, MN | 1 |
| Ndombo, PO | 1 |
| Gladwell, D | 1 |
| Batty, AJ | 1 |
| Brereton, N | 1 |
| Tate, E | 1 |
| Lee, CY | 1 |
| Liou, HH | 1 |
| Sánchez Fernández, I | 1 |
| An, S | 1 |
| Bergin, AM | 1 |
| Takeoka, M | 1 |
| Rotenberg, A | 1 |
| Kothare, SV | 1 |
| Riviello, JJ | 1 |
| Loddenkemper, T | 1 |
| Coles, LD | 1 |
| Patterson, EE | 1 |
| Sheffield, WD | 1 |
| Mavoori, J | 1 |
| Higgins, J | 1 |
| Michael, B | 1 |
| Leyde, K | 1 |
| Cloyd, JC | 3 |
| Litt, B | 1 |
| Vite, C | 1 |
| Worrell, GA | 1 |
| Abou-Khalil, B | 1 |
| Wheless, J | 1 |
| Rogin, J | 1 |
| Wolter, KD | 1 |
| Pixton, GC | 1 |
| Shukla, RB | 1 |
| Sherman, NA | 1 |
| Sommerville, K | 1 |
| Goli, V | 1 |
| Roland, CL | 1 |
| Lv, Y | 1 |
| Chu, F | 1 |
| Meng, H | 1 |
| Wang, Z | 1 |
| Cui, L | 1 |
| Zdebik, AA | 1 |
| Mahmood, F | 1 |
| Stanescu, HC | 1 |
| Kleta, R | 1 |
| Bockenhauer, D | 1 |
| Russell, C | 1 |
| Devinsky, O | 2 |
| Goldberg, R | 1 |
| Miles, D | 1 |
| Bojko, A | 1 |
| Riviello, J | 1 |
| Azuma, J | 1 |
| Nabatame, S | 1 |
| Nakano, S | 1 |
| Iwatani, Y | 1 |
| Kitai, Y | 1 |
| Tominaga, K | 1 |
| Kagitani-Shimono, K | 1 |
| Okinaga, T | 1 |
| Yamamoto, T | 1 |
| Nagai, T | 1 |
| Ozono, K | 1 |
| Kobayashi, K | 2 |
| Toda, Y | 2 |
| Verrotti, A | 1 |
| Milioni, M | 1 |
| Zaccara, G | 1 |
| Luo, Y | 1 |
| Hu, Q | 1 |
| Zhang, Q | 1 |
| Hong, S | 1 |
| Tang, X | 1 |
| Cheng, L | 1 |
| Jiang, L | 1 |
| Töllner, K | 1 |
| Twele, F | 1 |
| Löscher, W | 5 |
| Tohid, H | 1 |
| Vieira, V | 1 |
| Glassmann, D | 1 |
| Marafon, P | 1 |
| Pereira, P | 1 |
| Gomez, R | 1 |
| Su, Y | 1 |
| Liu, G | 1 |
| Tian, F | 1 |
| Ren, G | 1 |
| Jiang, M | 1 |
| Chun, B | 1 |
| Zhang, Y | 2 |
| Ye, H | 1 |
| Gao, D | 1 |
| Chen, W | 1 |
| Ikumi, ML | 1 |
| Muchohi, SN | 1 |
| Ohuma, EO | 1 |
| Kokwaro, GO | 1 |
| Newton, CR | 1 |
| Kanemoto, K | 1 |
| Tadokoro, Y | 1 |
| Oshima, T | 1 |
| Qashu, F | 1 |
| Figueiredo, TH | 1 |
| Aroniadou-Anderjaska, V | 1 |
| Apland, JP | 1 |
| Braga, MF | 1 |
| Bum, EN | 2 |
| Taiwe, GS | 1 |
| Nkainsa, LA | 1 |
| Moto, FC | 1 |
| Seke Etet, PF | 1 |
| Hiana, IR | 1 |
| Bailabar, T | 1 |
| Seyni, P | 1 |
| Rakotonirina, A | 1 |
| Rakotonirina, SV | 1 |
| Luongo, R | 1 |
| Oliveira, DA | 1 |
| Lebrun, I | 1 |
| Sandoval, MR | 1 |
| Singh, D | 1 |
| Goel, RK | 1 |
| Micale, V | 1 |
| Cristino, L | 1 |
| Tamburella, A | 1 |
| Petrosino, S | 1 |
| Leggio, GM | 1 |
| Drago, F | 1 |
| Di Marzo, V | 1 |
| Tilz, C | 1 |
| Resch, R | 1 |
| Hofer, T | 1 |
| Eggers, C | 1 |
| Tyzio, R | 1 |
| Khalilov, I | 1 |
| Represa, A | 2 |
| Crepel, V | 1 |
| Zilberter, Y | 1 |
| Rheims, S | 1 |
| Aniksztejn, L | 1 |
| Cossart, R | 1 |
| Nardou, R | 1 |
| Mukhtarov, M | 1 |
| Minlebaev, M | 1 |
| Epsztein, J | 1 |
| Milh, M | 1 |
| Becq, H | 1 |
| Jorquera, I | 1 |
| Bulteau, C | 1 |
| Fohlen, M | 1 |
| Oliver, V | 1 |
| Dulac, O | 2 |
| Dorfmüller, G | 1 |
| Delalande, O | 1 |
| Ben-Ari, Y | 2 |
| Khazipov, R | 1 |
| de Haan, GJ | 1 |
| van der Geest, P | 1 |
| Doelman, G | 1 |
| Bertram, E | 1 |
| Edelbroek, P | 1 |
| Cysneiros, RM | 1 |
| Ferrari, D | 1 |
| Arida, RM | 1 |
| Terra, VC | 1 |
| de Almeida, AC | 1 |
| Cavalheiro, EA | 6 |
| Scorza, FA | 2 |
| Raza, ML | 1 |
| Zeeshan, M | 1 |
| Ahmad, M | 1 |
| Shaheen, F | 1 |
| Simjee, SU | 1 |
| Wolf, P | 1 |
| Holsti, M | 1 |
| Dudley, N | 1 |
| Schunk, J | 1 |
| Adelgais, K | 1 |
| Greenberg, R | 1 |
| Olsen, C | 1 |
| Healy, A | 1 |
| Firth, S | 1 |
| Filloux, F | 1 |
| Fusco, L | 1 |
| Specchio, N | 1 |
| Ciofetta, G | 1 |
| Longo, D | 2 |
| Trivisano, M | 1 |
| Ratsimbazafy, V | 1 |
| Andrianabelina, R | 1 |
| Randrianarisona, S | 1 |
| Preux, PM | 1 |
| Odermatt, P | 1 |
| Chiang, LM | 1 |
| Wang, HS | 1 |
| Shen, HH | 1 |
| Deng, ST | 1 |
| Tseng, CH | 1 |
| Chen, YI | 1 |
| Chou, ML | 1 |
| Hung, PC | 1 |
| Lin, KL | 1 |
| Chen, WB | 1 |
| Gao, R | 1 |
| Su, YY | 1 |
| Zhao, JW | 1 |
| Zhang, YZ | 1 |
| Wang, L | 1 |
| Ren, Y | 1 |
| Fan, CQ | 1 |
| Venturin, GT | 1 |
| Greggio, S | 1 |
| Marinowic, DR | 1 |
| Zanirati, G | 1 |
| Cammarota, M | 1 |
| Machado, DC | 1 |
| DaCosta, JC | 1 |
| Jeon, D | 1 |
| Chu, K | 1 |
| Lee, ST | 1 |
| Jung, KH | 1 |
| Kang, KM | 1 |
| Ban, JJ | 1 |
| Kim, S | 1 |
| Seo, JS | 1 |
| Won, CH | 1 |
| Kim, M | 1 |
| Lee, SK | 1 |
| Roh, JK | 1 |
| Zhu, G | 1 |
| Yoshida, S | 1 |
| Migita, K | 1 |
| Yamada, J | 1 |
| Mori, F | 1 |
| Tomiyama, M | 1 |
| Wakabayashi, K | 1 |
| Kanematsu, T | 1 |
| Hirata, M | 1 |
| Kaneko, S | 1 |
| Ueno, S | 1 |
| Okada, M | 2 |
| Tan, GH | 1 |
| Liu, YY | 1 |
| Hu, XL | 1 |
| Yin, DM | 1 |
| Mei, L | 1 |
| Xiong, ZQ | 1 |
| Reddy, DS | 3 |
| Gould, J | 1 |
| Gangisetty, O | 1 |
| Sayers, KW | 1 |
| Nguyen, PT | 1 |
| Blair, RE | 1 |
| Sim-Selley, LJ | 1 |
| DeLorenzo, RJ | 1 |
| Hamzeh Gooshchi, N | 1 |
| Seiednejad-Yamchi, S | 1 |
| Okomolo, FC | 1 |
| Mbafor, JT | 1 |
| Kouemou, N | 1 |
| Kandeda, AK | 1 |
| Talla, E | 1 |
| Dimo, T | 1 |
| Rakotonirira, A | 1 |
| Rakotonirira, SV | 1 |
| Albus, K | 1 |
| Wahab, A | 1 |
| Heinemann, U | 1 |
| Senthilraja, M | 1 |
| Alagarsamy, V | 1 |
| Kazmi, I | 1 |
| Afzal, M | 1 |
| Gupta, G | 1 |
| Anwar, F | 1 |
| Funnell, M | 1 |
| Ranta, A | 1 |
| Hayashi, Y | 1 |
| Inoue, T | 1 |
| Oka, M | 1 |
| Ohtsuka, Y | 1 |
| Gualtieri, F | 1 |
| Marinelli, C | 1 |
| Pugnaghi, M | 1 |
| Nichelli, PF | 1 |
| Meletti, S | 1 |
| Biagini, G | 1 |
| da Cruz, GM | 1 |
| Felipe, CF | 1 |
| da Costa, MA | 1 |
| Tavares, AF | 1 |
| Menezes, ML | 1 |
| de Andrade, GM | 1 |
| Leal, LK | 1 |
| Brito, GA | 1 |
| da Graça Naffah-Mazzacoratti, M | 1 |
| de Barros Viana, GS | 1 |
| Mussulini, BH | 1 |
| Leite, CE | 1 |
| Zenki, KC | 1 |
| Moro, L | 1 |
| Baggio, S | 1 |
| Rico, EP | 1 |
| Rosemberg, DB | 1 |
| Dias, RD | 1 |
| Souza, TM | 1 |
| Calcagnotto, ME | 1 |
| Campos, MM | 1 |
| Battastini, AM | 1 |
| de Oliveira, DL | 1 |
| Araki, T | 1 |
| Simon, RP | 1 |
| Taki, W | 1 |
| Lan, JQ | 1 |
| Henshall, DC | 1 |
| Bowser, DN | 1 |
| Wagner, DA | 1 |
| Czajkowski, C | 1 |
| Cromer, BA | 1 |
| Parker, MW | 1 |
| Wallace, RH | 1 |
| Harkin, LA | 1 |
| Mulley, JC | 1 |
| Marini, C | 1 |
| Berkovic, SF | 1 |
| Williams, DA | 1 |
| Jones, MV | 1 |
| Petrou, S | 1 |
| Delmont, E | 1 |
| Bourg, V | 1 |
| Thomas, P | 1 |
| Murphy, A | 1 |
| Wilbur, K | 1 |
| Sterrick, M | 1 |
| Foley, J | 1 |
| Bråthen, G | 1 |
| ROSA, JJ | 1 |
| MIRVILLANUE, VA | 1 |
| KALINA, RK | 1 |
| ARRIGO, A | 2 |
| SAVOLDI, F | 1 |
| TARTARA, A | 2 |
| BARSA, JA | 1 |
| SAUNDERS, JC | 1 |
| BARRERAPEREZ, S | 1 |
| HARDER, A | 1 |
| WEINBERG, WA | 1 |
| HARWELL, JL | 1 |
| GALAMBOS, M | 2 |
| BARTEN, HH | 1 |
| GASTAUT, H | 8 |
| NAQUET, R | 3 |
| POIRE, R | 2 |
| TASSINARI, CA | 3 |
| Hansen, SL | 1 |
| Sperling, BB | 1 |
| Sánchez, C | 1 |
| Okumura, A | 1 |
| Ishiguro, Y | 1 |
| Sofue, A | 1 |
| Suzuki, Y | 1 |
| Maruyama, K | 1 |
| Kubota, T | 1 |
| Negoro, T | 2 |
| Watanabe, K | 2 |
| Pellock, JM | 5 |
| Yamashita, H | 1 |
| Ohno, K | 1 |
| Inami, H | 1 |
| Shishikura, J | 1 |
| Sakamoto, S | 1 |
| Yamaguchi, T | 1 |
| Suzuki, K | 1 |
| Kobayashi, M | 1 |
| Tokue, A | 1 |
| Püst, B | 1 |
| Buznego, MT | 1 |
| Pérez-Saad, H | 1 |
| Hosseinzadeh, H | 1 |
| Parvardeh, S | 1 |
| Nassiri-Asl, M | 1 |
| Mansouri, MT | 1 |
| Shinnar, S | 2 |
| Voermans, NC | 1 |
| Zwarts, MJ | 1 |
| Renier, WO | 2 |
| Bloem, BR | 1 |
| O'Dell, C | 3 |
| Ballaban-Gil, KR | 1 |
| Hornick, M | 1 |
| Sigalova, M | 1 |
| Kang, H | 1 |
| Moshé, SL | 1 |
| Matsumoto, R | 1 |
| Ikeda, A | 1 |
| Hitomi, T | 1 |
| Aoki, T | 1 |
| Hanakawa, T | 1 |
| Miki, Y | 1 |
| Tomimoto, H | 1 |
| Shimohama, S | 1 |
| Shibasaki, H | 1 |
| Bhattacharyya, M | 1 |
| Kalra, V | 1 |
| Gulati, S | 1 |
| Day, B | 1 |
| Schmitt, FC | 1 |
| Buchheim, K | 1 |
| Meierkord, H | 1 |
| Holtkamp, M | 1 |
| Fukumitsu, N | 1 |
| Ogi, S | 1 |
| Uchiyama, M | 1 |
| Mori, Y | 1 |
| von Wrede, R | 1 |
| Huyton, M | 1 |
| Mair, K | 1 |
| Hindley, D | 1 |
| Strohl, KP | 1 |
| Gallaugher, L | 1 |
| Lynn, A | 1 |
| Friedman, L | 1 |
| Hill, A | 1 |
| Singer, JB | 1 |
| Lander, ES | 1 |
| Nadeau, J | 1 |
| Cucullo, L | 1 |
| Hossain, M | 1 |
| Rapp, E | 1 |
| Manders, T | 1 |
| Marchi, N | 1 |
| Janigro, D | 1 |
| Engelhorn, T | 1 |
| Weise, J | 1 |
| Hammen, T | 1 |
| Bluemcke, I | 1 |
| Hufnagel, A | 1 |
| Doerfler, A | 1 |
| Marqués-Marí, AI | 1 |
| Nacher, J | 1 |
| Crespo, C | 1 |
| Gutièrrez-Mecinas, M | 1 |
| Martínez-Guijarro, FJ | 1 |
| Blasco-Ibáñez, JM | 1 |
| Kiel, S | 1 |
| McCullough, K | 1 |
| Addae, JI | 1 |
| Ali, N | 1 |
| Youssef, FF | 1 |
| Stone, TW | 1 |
| Terry, D | 1 |
| Paolicchi, J | 1 |
| Karn, M | 1 |
| Mihajlovic-Madzarevic, V | 1 |
| Pappas, P | 1 |
| Ali, A | 1 |
| Christian, D | 1 |
| Chung, E | 1 |
| Pericić, D | 1 |
| Vlainić, J | 1 |
| Strac, DS | 1 |
| Baum, P | 1 |
| Kopf, A | 1 |
| Hermann, W | 1 |
| Wagner, A | 1 |
| Roger, J | 7 |
| Boudouresques, J | 1 |
| Toga, M | 1 |
| Dubois, D | 1 |
| Lob, H | 3 |
| Coffey, B | 1 |
| Shader, RI | 1 |
| Greenblatt, DJ | 1 |
| Johnson, DD | 3 |
| Fisher, TE | 2 |
| Tuchek, JM | 3 |
| Crawford, RD | 4 |
| Mimaki, T | 1 |
| Tagawa, T | 1 |
| Ono, J | 1 |
| Tanaka, J | 1 |
| Terada, H | 1 |
| Itoh, N | 1 |
| Yabuuchi, H | 1 |
| Gotman, J | 1 |
| Gloor, P | 1 |
| Quesney, LF | 1 |
| Olivier, A | 1 |
| Shandra, AA | 1 |
| Kryzhanovskiĭ, GN | 3 |
| Asano, T | 1 |
| Mizutani, A | 1 |
| Milligan, NM | 1 |
| Dhillon, S | 6 |
| Griffiths, A | 1 |
| Oxley, J | 5 |
| Richens, A | 10 |
| Loiseau, P | 2 |
| Franzoni, E | 1 |
| Carboni, C | 1 |
| Lambertini, A | 1 |
| Hvidberg, EF | 1 |
| Escorihuela, R | 1 |
| Sandiumenge, J | 1 |
| Atri, PB | 1 |
| Julius, DA | 1 |
| Kaminer, Y | 1 |
| Munitz, H | 1 |
| Addy, DP | 1 |
| Scollo-Lavizzari, G | 2 |
| Staudt, F | 1 |
| Helwig, H | 2 |
| de Campos, CJ | 1 |
| Izquierdo, I | 1 |
| McNamara, JO | 2 |
| Peper, AM | 1 |
| Patrone, V | 1 |
| Holliday, TA | 1 |
| Ngwane, E | 1 |
| Milligan, N | 1 |
| Ogunmekan, AO | 1 |
| Alberton, TE | 1 |
| Bowyer, JF | 1 |
| Debruyne, D | 1 |
| Moulin, MA | 1 |
| Camsonne, R | 1 |
| Bigot, MC | 1 |
| Dravet, C | 3 |
| Dalla Bernardina, B | 1 |
| Mesdjian, E | 1 |
| Galland, MC | 1 |
| Gersdorff, MC | 1 |
| Wright, M | 1 |
| Mumford, CJ | 1 |
| Warlow, CP | 1 |
| Somerville, ER | 1 |
| Antony, JH | 1 |
| Tojo, M | 1 |
| Reisner-Keller, LA | 1 |
| Pham, Z | 1 |
| Appleton, R | 1 |
| Sweeney, A | 1 |
| Choonara, I | 1 |
| Robson, J | 1 |
| Molyneux, E | 1 |
| Lemos, T | 2 |
| Mealey, KL | 1 |
| Boothe, DM | 1 |
| Gandolfo, G | 1 |
| Scherschlicht, R | 1 |
| Gottesmann, C | 1 |
| Pollard, H | 1 |
| Charriaut-Marlangue, C | 1 |
| Cantagrel, S | 1 |
| Robain, O | 1 |
| Moreau, J | 1 |
| Elterman, RD | 1 |
| Lammers, MW | 1 |
| Wijsman, DJ | 1 |
| Hekster, YA | 1 |
| Keyser, A | 1 |
| Meinardi, H | 3 |
| van Lier, H | 1 |
| Huang, ZC | 3 |
| Martin, PJ | 1 |
| Millac, PA | 1 |
| Smith, SE | 1 |
| al-Zubaidy, ZA | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 2 |
| Davidson, DL | 1 |
| Shetty, T | 1 |
| Kaplan, PW | 1 |
| Tusa, RJ | 1 |
| Korinthenberg, R | 2 |
| Shen, DL | 2 |
| Nagai, H | 1 |
| Ikeno, T | 1 |
| Mitchell, WG | 3 |
| Knudsen, FU | 6 |
| Paerregaard, A | 1 |
| Andersen, R | 1 |
| Andresen, J | 1 |
| Ferrarese, C | 1 |
| Perego, M | 1 |
| Marzorati, C | 1 |
| Bianchi, G | 1 |
| Frigo, M | 1 |
| Pecora, N | 1 |
| Riva, R | 1 |
| Moretti, G | 1 |
| Frattola, L | 1 |
| Podell, M | 3 |
| Silva, ML | 1 |
| Cieuta, C | 1 |
| Guerrini, R | 1 |
| Plouin, P | 1 |
| Livet, MO | 1 |
| De Sarro, G | 1 |
| Di Paola, ED | 1 |
| Aguglia, U | 1 |
| de Sarro, A | 2 |
| Cervantes, M | 1 |
| Antonio-Ocampo, A | 1 |
| Ruelas, R | 1 |
| Contreras-Gómez, A | 1 |
| Chávez-Carrillo, I | 1 |
| Morton, LD | 1 |
| Rizkallah, E | 1 |
| Camfield, PR | 1 |
| Camfield, CS | 1 |
| Becker, A | 1 |
| Tiedge, A | 1 |
| Grecksch, GA | 1 |
| Guedes, RC | 1 |
| Pothmann, R | 1 |
| Eder, HG | 3 |
| Jones, DB | 1 |
| Fisher, RS | 3 |
| Blend, MJ | 1 |
| de León, OA | 1 |
| Jobe, TH | 1 |
| Lin, Q | 1 |
| Sychra, JJ | 1 |
| Gaviria, M | 1 |
| Yoshizawa, T | 1 |
| Anno, I | 1 |
| Matsumura, A | 1 |
| Enomoto, T | 1 |
| Yamada, H | 1 |
| Muraki, S | 1 |
| Itai, Y | 1 |
| Nose, T | 1 |
| Stein, A | 1 |
| Morimoto, K | 1 |
| Sato, H | 1 |
| Sato, K | 1 |
| Sato, S | 1 |
| Yamada, N | 1 |
| O'Regan, ME | 1 |
| Brown, JK | 1 |
| Bazil, CW | 1 |
| Pedley, TA | 1 |
| Nissenkorn, A | 1 |
| Lerman-Sagie, T | 1 |
| Dreifuss, FE | 1 |
| Rosman, NP | 3 |
| Kuzniecky, RI | 1 |
| Lo, WD | 1 |
| Matsuo, F | 1 |
| Sharp, GB | 1 |
| Conry, JA | 2 |
| Bergen, DC | 1 |
| Bell, WE | 1 |
| Vining, EP | 2 |
| Brusentsov, AI | 1 |
| Yamagata, Y | 1 |
| Obata, K | 1 |
| Lanfear, JH | 1 |
| Rashid, C | 1 |
| Klitgaard, H | 1 |
| Matagne, A | 1 |
| Gobert, J | 1 |
| Wülfert, E | 1 |
| Graves, N | 1 |
| Wolf, SM | 1 |
| Ochoa, JG | 1 |
| Conway, EE | 1 |
| Wagner, SO | 1 |
| Sams, RA | 1 |
| Maj, R | 1 |
| Fariello, RG | 1 |
| Ukmar, G | 1 |
| Varasi, M | 1 |
| Pevarello, P | 1 |
| McArthur, RA | 1 |
| Salvati, P | 1 |
| Shafrir, Y | 1 |
| Masson, C | 1 |
| Kriel, RL | 2 |
| Cereghino, JJ | 2 |
| Ellis, SJ | 1 |
| Baddely, L | 1 |
| Scheepers, M | 1 |
| Comish, S | 1 |
| Cordes, L | 1 |
| Clough, P | 1 |
| Scheepers, B | 1 |
| Chattopadhyay, A | 1 |
| Morris, B | 1 |
| Blackburn, L | 1 |
| Wassmer, E | 1 |
| Whitehouse, W | 1 |
| Baumann, RJ | 1 |
| Brodtkorb, E | 2 |
| Aamo, T | 1 |
| Henriksen, O | 1 |
| Lossius, R | 1 |
| Nicholl, JS | 1 |
| Crumrine, PK | 1 |
| Groves, L | 1 |
| Rosenfeld, WE | 1 |
| Jeannet, PY | 1 |
| Roulet, E | 1 |
| Maeder-Ingvar, M | 1 |
| Gehri, M | 1 |
| Jutzi, A | 1 |
| Deonna, T | 1 |
| Jelovac, N | 1 |
| Sikiric, P | 1 |
| Rucman, R | 1 |
| Petek, M | 1 |
| Perovic, D | 1 |
| Marovic, A | 1 |
| Anic, T | 1 |
| Seiwerth, S | 1 |
| Mise, S | 1 |
| Pigac, B | 1 |
| Duplancie, B | 1 |
| Turkovic, B | 1 |
| Dodig, G | 1 |
| Prkacin, I | 1 |
| Stancic-Rokotov, D | 1 |
| Zoricic, I | 1 |
| Aralica, G | 1 |
| Sebecic, B | 1 |
| Ziger, T | 1 |
| Slobodnjak, Z | 1 |
| Coral, P | 1 |
| Zanatta, A | 1 |
| Teive, HA | 1 |
| Correa Neto, Y | 1 |
| Nóvak, EM | 1 |
| Werneck, LC | 1 |
| Jenck, F | 1 |
| Wichmann, J | 1 |
| Dautzenberg, FM | 1 |
| Moreau, JL | 1 |
| Ouagazzal, AM | 1 |
| Martin, JR | 1 |
| Lundstrom, K | 1 |
| Cesura, AM | 1 |
| Poli, SM | 1 |
| Roever, S | 1 |
| Kolczewski, S | 1 |
| Adam, G | 1 |
| Kilpatrick, G | 1 |
| Stein, AG | 1 |
| Blum, DE | 1 |
| Drachev, A | 1 |
| Dunworth, SJ | 1 |
| Mead, AN | 1 |
| Stephens, DN | 1 |
| Khanna, N | 1 |
| Bhalla, S | 1 |
| Rogawski, MA | 2 |
| Yoon, Y | 1 |
| Jagoda, A | 1 |
| Bazyan, AS | 1 |
| Zhulin, VV | 1 |
| Karpova, MN | 1 |
| Klishina, NY | 1 |
| Glebov, RN | 1 |
| Lin, J | 1 |
| Ritchie, GD | 1 |
| Stenger, DA | 1 |
| Nordholm, AF | 1 |
| Pancrazio, JJ | 1 |
| Rossi, J | 1 |
| Temkin, NR | 1 |
| Vanaja, P | 1 |
| Jayakumar, AR | 1 |
| Tiffin, PA | 1 |
| Perini, AF | 1 |
| Bianchi, MT | 1 |
| Song, L | 1 |
| Zhang, H | 1 |
| Macdonald, RL | 1 |
| Bohlen, N | 1 |
| Hertl, M | 1 |
| Kristof, M | 1 |
| Servít, Z | 1 |
| Hopkins, A | 1 |
| Scambler, G | 1 |
| Gromov, SA | 1 |
| Rowan, AJ | 1 |
| Pippenger, CE | 2 |
| McGregor, PA | 1 |
| French, JH | 1 |
| Speciali, GG | 1 |
| Lison, MP | 2 |
| Kurokawa, T | 1 |
| Yokota, K | 1 |
| Mitsudome, A | 1 |
| Shibata, R | 1 |
| Takashima, S | 1 |
| Goya, N | 1 |
| Azcarate, CL | 1 |
| Lechner, H | 1 |
| Hebenstreit, G | 1 |
| Ahmad, S | 1 |
| Laidlaw, J | 1 |
| Houghton, GW | 2 |
| Dhar, AK | 1 |
| Kutt, H | 3 |
| Aicardi, J | 1 |
| Borgheresi, S | 1 |
| Luti, E | 1 |
| Buti Cossi, D | 1 |
| Mecherini, L | 1 |
| Bardini, MR | 1 |
| Burgio, E | 1 |
| Ciampi, C | 1 |
| Benocci, M | 1 |
| Massai, S | 1 |
| Lini, M | 1 |
| Grifi, G | 1 |
| Valenza, T | 1 |
| Wada, JA | 1 |
| Bruni, J | 1 |
| Willmore, LJ | 1 |
| Marks, P | 1 |
| Anderson, J | 1 |
| Vincent, R | 1 |
| Hutchinson, JT | 1 |
| Rees, HM | 1 |
| Mori, T | 1 |
| Kato, H | 1 |
| Ikeda, S | 1 |
| Morizaki, I | 1 |
| Wilkinson, HA | 2 |
| Lumholtz, IB | 1 |
| Lakos, P | 1 |
| Czeizel, E | 1 |
| Passarge, C | 1 |
| Faugier-Grimaud, S | 1 |
| Dodson, WE | 1 |
| Prensky, AL | 1 |
| DeVivo, DC | 1 |
| Goldring, S | 1 |
| Dodge, PR | 1 |
| Osuntokun, BO | 1 |
| Gibberd, FB | 1 |
| Lombardo, L | 1 |
| Toone, BK | 1 |
| Fenton, GW | 1 |
| Schneider, S | 2 |
| Lapin, AA | 1 |
| Dam, M | 1 |
| Christiansen, J | 1 |
| Walker, N | 1 |
| Egli, M | 1 |
| Wellauer, J | 1 |
| Coulthard, MG | 1 |
| Raskin, NH | 1 |
| Fishman, RA | 1 |
| Mertin, J | 1 |
| Simon, O | 1 |
| Schmiedek, P | 1 |
| Ames, FR | 1 |
| Enderstein, O | 1 |
| Dravat, C | 1 |
| Gustaut, H | 1 |
| Gordon, EB | 1 |
| Bentley, G | 1 |
| Mellick, R | 1 |
| Eadie, MJ | 2 |
| Wakayama, S | 1 |
| Taniguchi, K | 1 |
| Toyota, M | 1 |
| Maida, C | 1 |
| Kawaguchi, S | 1 |
| Anlezark, G | 1 |
| Balzamo, E | 1 |
| Horton, RW | 1 |
| Trimble, M | 1 |
| Nicol, CF | 2 |
| Malatinský, J | 1 |
| Procházka, M | 3 |
| Sámel, M | 1 |
| Huang, Z | 1 |
| De Sarro, GB | 1 |
| Rotiroti, D | 1 |
| Gratteri, S | 1 |
| Sinopoli, S | 1 |
| Juliano, M | 1 |
| Hart, YM | 2 |
| Sander, JW | 2 |
| Nutt, DJ | 3 |
| Shorvon, SD | 2 |
| Dudkin, AO | 1 |
| Shanmugasundaram, ER | 1 |
| Akbar, GK | 1 |
| Shanmugasundaram, KR | 1 |
| Anai, T | 1 |
| Hirota, Y | 1 |
| Oga, M | 1 |
| Yoshimatsu, J | 1 |
| Miyakawa, I | 1 |
| De Negri, M | 1 |
| Gaggero, R | 1 |
| Veneselli, E | 1 |
| Pessagno, A | 1 |
| Baglietto, MG | 1 |
| Pallecchi, A | 1 |
| Peeters, BW | 1 |
| Van Rijn, CM | 1 |
| Titulaer, MN | 1 |
| Vossen, JM | 1 |
| Coenen, AM | 2 |
| Hishida, H | 1 |
| Caboche, J | 1 |
| Mitrovic, N | 1 |
| Le Saux, F | 1 |
| Besson, MJ | 1 |
| Sauter, A | 1 |
| Maurin, Y | 1 |
| Klosterkötter, J | 1 |
| Penin, H | 1 |
| Connell, J | 1 |
| Oozeer, R | 1 |
| de Vries, L | 1 |
| Dubowitz, LM | 1 |
| Dubowitz, V | 1 |
| van Luijtelaar, EL | 1 |
| Bromfield, EB | 1 |
| Dambrosia, J | 1 |
| Nice, FJ | 1 |
| Theodore, WH | 1 |
| Baran, H | 1 |
| Hörtnagl, H | 1 |
| Hornykiewicz, O | 1 |
| Fisher, JE | 1 |
| Schmidt, D | 1 |
| Fredow, G | 1 |
| Hönack, D | 2 |
| Iturrian, WB | 1 |
| Oberholzer, DJ | 1 |
| Rennert, H | 1 |
| McGeer, E | 1 |
| McGeer, PL | 1 |
| Jonesco-Benaiche, N | 1 |
| Jasmin, JR | 1 |
| Davis, LG | 1 |
| Bordiukov, MM | 1 |
| Nikushkin, EV | 1 |
| Bogdanova, ED | 1 |
| Prilipko, LL | 1 |
| Ogata, N | 1 |
| Matsuo, T | 1 |
| Inoue, M | 1 |
| Nolting, B | 1 |
| Janicki, PK | 1 |
| Gumulka, SW | 1 |
| Rewekant, M | 1 |
| Pisarski, W | 1 |
| Jedrzejowska, H | 1 |
| De Domenico, P | 1 |
| Gallitto, G | 1 |
| Musolino, R | 1 |
| Bonanzinga, M | 1 |
| Troilo, G | 1 |
| Di Perri, R | 1 |
| Sacchi, C | 1 |
| Meyer, FP | 1 |
| Walther, H | 1 |
| Pedder, SC | 1 |
| Wilcox, R | 1 |
| Bernasconi, R | 1 |
| Marescaux, C | 1 |
| Vergnes, M | 1 |
| Klebs, K | 1 |
| Klein, M | 1 |
| Martin, P | 1 |
| Portet, C | 1 |
| Maitre, L | 1 |
| Schmutz, M | 1 |
| Jawad, S | 2 |
| Yuen, WC | 1 |
| De Riu, PL | 1 |
| Mameli, O | 1 |
| Tolu, E | 1 |
| Lutz, EG | 1 |
| Lutz, MB | 1 |
| Lutz, GE | 1 |
| Razdan, S | 1 |
| Koul, RL | 1 |
| Bulakhova, LA | 1 |
| Martyniuk, VIu | 1 |
| Drake, ME | 1 |
| Farrell, K | 1 |
| Wilson, J | 2 |
| Crichlow, EC | 1 |
| Mishra, PR | 1 |
| Frey, HH | 1 |
| Godbout, R | 1 |
| Montplaisir, J | 1 |
| Rouleau, I | 1 |
| Sobotka, P | 1 |
| Navrátil, L | 1 |
| Herranz Fernández, JL | 1 |
| Tudor, I | 2 |
| Falconer, MA | 1 |
| Davidson, S | 1 |
| Penry, JK | 2 |
| Kraft, D | 1 |
| Schaefer, K | 1 |
| Bochentin, W | 1 |
| von Herrath, D | 1 |
| Opitz, A | 1 |
| Koeppe, P | 1 |
| Tyrer, JH | 1 |
| Laitinen, L | 1 |
| Toivakka, E | 1 |
| Aleksandrovskiĭ, IuA | 2 |
| But, PG | 1 |
| Kaplunskiĭ, GD | 1 |
| poltorakov, AP | 1 |
| Chibrikin, VM | 1 |
| Parsonage, M | 2 |
| Pomina, AC | 1 |
| Tarlau, M | 1 |
| Berman, AJ | 1 |
| Jaffe, R | 1 |
| Christoff, NJ | 1 |
| Ravenna, C | 1 |
| Lion, P | 1 |
| Ebe, M | 2 |
| Meier-Ewert, K | 1 |
| Broughton, R | 2 |
| Dalby, MA | 1 |
| Kurtz, D | 2 |
| Tempe, JD | 2 |
| Weber, M | 2 |
| Feuerstein, J | 2 |
| Reeb, M | 2 |
| Mantz, JM | 2 |
| Otto, JL | 1 |
| Schlagenhauf, G | 1 |
| Killam, KF | 1 |
| Killam, EK | 1 |
| Catier, J | 2 |
| Lavy, S | 1 |
| Assael, M | 1 |
| Hershon, HI | 1 |
| Meier-Ewert, KH | 1 |
| Niedermeyer, E | 4 |
| Baird, HW | 1 |
| van Duijn, H | 2 |
| Leonidas, JC | 1 |
| Brill, PW | 1 |
| Waldman, N | 1 |
| Browne, TR | 1 |
| Livingston, S | 1 |
| Ferngren, HG | 1 |
| Forman, PM | 1 |
| Saper, JR | 1 |
| Lossing, JH | 1 |
| Greene, CA | 1 |
| Rao, VS | 1 |
| Papeschi, R | 1 |
| Molina-Negro, P | 1 |
| Sourkes, TL | 1 |
| Erba, G | 1 |
| Schreiber, KA | 1 |
| Gibbs, FA | 1 |
| Anderson, EM | 1 |
| Canger, R | 1 |
| Borenstein, P | 1 |
| Champion, C | 1 |
| Cujo, P | 1 |
| Gekière, F | 1 |
| Olivenstein, C | 1 |
| Kramarz, P | 1 |
| Fukuyama, Y | 1 |
| Millichap, JG | 1 |
| Freeman, JM | 1 |
| Lietman, PS | 1 |
| Hooshmand, H | 1 |
| Lehmann, HE | 1 |
| Ban, TA | 1 |
| Friedlander, WJ | 1 |
| Gardner-Thorpe, C | 1 |
| Parsonage, MJ | 1 |
| Toothill, C | 1 |
| Hertrich, O | 1 |
| Leibovitz, U | 1 |
| Ritter, G | 1 |
| Louis, S | 1 |
| Josephson, DA | 1 |
| Abraham, U | 1 |
| Cavazzuti, GB | 1 |
| Noble, IM | 1 |
| Jansen, F | 1 |
| Martinius, J | 1 |
| Matthes, A | 1 |
| Siris, JH | 1 |
| Werner, WL | 1 |
| Masland, RL | 1 |
| Saletu, B | 1 |
| Saletu, M | 1 |
| Itil, T | 1 |
| Scamoni, C | 1 |
| Presazzi, A | 1 |
| Tharp, BR | 1 |
| Uphold, JD | 1 |
| Prokudin, VN | 1 |
| Martin, D | 2 |
| Hirt, HR | 2 |
| Lombroso, CT | 3 |
| Stark, LG | 1 |
| Edmonds, HL | 1 |
| Keesling, P | 1 |
| Burnett, LL | 1 |
| Struve, FA | 1 |
| Chien, C | 1 |
| Keegan, D | 1 |
| Visser, SL | 1 |
| Prior, PF | 1 |
| Maclaine, GN | 1 |
| Scott, DF | 1 |
| Laurance, BM | 1 |
| Hohenauer, L | 1 |
| Zsadányi, O | 1 |
| Molnár, C | 1 |
| Novotný, P | 1 |
| Langevin, P | 1 |
| Panther, W | 1 |
| Conchie, AF | 1 |
| Lowis, GR | 1 |
| West, JR | 1 |
| Bauer, G | 1 |
| Caso, A | 1 |
| Raphael-Fernández, G | 1 |
| Romo, A | 1 |
| Martínez, C | 1 |
| Garibay, E | 1 |
| Padilla, J | 1 |
| Booker, HE | 1 |
| Celesia, GG | 1 |
| Chemburkar, JA | 1 |
| Ravindranath, S | 1 |
| Desai, AD | 1 |
| Mace, JW | 1 |
| Conomy, JP | 1 |
| Holmquest, DL | 1 |
| Launey, WS | 1 |
| Barksdale, CR | 1 |
| Hill, RM | 1 |
| Verniaud, WM | 1 |
| Horning, MG | 1 |
| McCulley, LB | 1 |
| Morgan, NF | 1 |
| Wilson, JT | 1 |
| Carter, S | 2 |
| Gold, A | 2 |
| Angst, J | 1 |
| Ristić, J | 1 |
| Trolle, E | 1 |
| Müller, HR | 1 |
| Klingler, M | 1 |
| Kaeser, HE | 2 |
| Wurmser, P | 1 |
| Henriksen, PB | 1 |
| Scharfetter, C | 1 |
| Schmoigl, S | 1 |
| Bell, DS | 3 |
| Declerck, A | 1 |
| Tutton, JC | 2 |
| Smith, BH | 1 |
| Elian, M | 1 |
| Degen, R | 1 |
| Moe, PG | 1 |
| Geller, M | 1 |
| Christoff, N | 1 |
| Dowzenko, A | 1 |
| Huber, Z | 1 |
| Zieliński, JJ | 1 |
| Borkowska, Z | 1 |
| Mazurkowa, K | 1 |
| Wojakowski, A | 1 |
| Weinmann, HM | 1 |
| Máttyus, A | 1 |
| Halász, A | 1 |
| Kovács, J | 1 |
| Garofalo, P | 1 |
| Bonenti, G | 1 |
| De Petris, MP | 1 |
| Whitty, CW | 1 |
| Oxbury, JM | 1 |
| Bower, BD | 1 |
| Finavera, L | 1 |
| Mascetti, A | 1 |
| Zamberletti, P | 1 |
| Rosenmayr, F | 1 |
| Groh, C | 1 |
| Cendrowski, W | 1 |
| Majkowski, J | 1 |
| Vajnorský, J | 1 |
| Healy, TE | 1 |
| Edmondson, HD | 1 |
| Hall, N | 1 |
| Courjon, J | 2 |
| Vitols, A | 1 |
| Kamianov, IM | 1 |
| Ledić, P | 1 |
| Antonćić, N | 1 |
| Sepcić, J | 1 |
| Ekstedt, J | 1 |
| Speciali, JG | 1 |
| Utz, W | 1 |
| Spehlmann, R | 1 |
| Daniels, JC | 1 |
| Chang, CM | 1 |
| Gordon, NS | 1 |
| McMorris, S | 1 |
| McWilliam, PK | 1 |
| Royer, J | 1 |
| Hess, R | 1 |
| Nathan, PW | 1 |
| Averill, DR | 1 |
| Sourek, K | 2 |
| Trávnícek, V | 1 |
| Brett, EM | 1 |
| Goddard, P | 1 |
| Lokare, VG | 1 |
| Gumpert, J | 1 |
| Hansotia, P | 1 |
| Upton, A | 1 |
| Hajnsek, F | 1 |
| Gubarev, N | 1 |
| Bogolepov, NK | 1 |
| Burd, GS | 1 |
| Fedin, AI | 1 |
| Cossette, A | 1 |
| Naess, K | 1 |
| Tresise, PC | 1 |
| Stenhouse, NS | 1 |
| Magyar, I | 1 |
| Schwartz, JF | 1 |
| Howard, FM | 1 |
| Seybold, ME | 1 |
| Reiher, J | 1 |
| Eisenmann, M | 1 |
| Friedel, B | 1 |
| Reimer, F | 1 |
| Fukushima, Y | 1 |
| Akihama, Y | 1 |
| Shibuki, K | 1 |
| Sato, A | 1 |
| Little, SC | 1 |
| Green, J | 1 |
| Carlier, G | 1 |
| White, PT | 1 |
| Dyken, PR | 1 |
| Gath, I | 1 |
| Louhimo, T | 1 |
| Hollis, DA | 1 |
| Revol, M | 1 |
| Gerin, P | 1 |
| Fischer, G | 1 |
| Soulayrol, R | 1 |
| Oller-Daurella, L | 1 |
| Ferrari, G | 1 |
| Tajoli, E | 1 |
| Verlato, R | 1 |
| Henking, R | 1 |
| Rallo Piquè, E | 1 |
| Abad, V | 1 |
| Calderon-Gonzalez, R | 1 |
| Hopkins, I | 1 |
| McLean, WT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-Label, Repeat-Dose Pharmacokinetics Study of NRL-1 in Epilepsy Subjects Under Seizure and Normal Conditions[NCT02724423] | Phase 1 | 57 participants (Actual) | Interventional | 2016-06-30 | Completed | ||
| A 12-Month Open-Label, Repeat-Dose Safety Study of NRL-1 in Epilepsy Subjects (DIAZ.001.05)[NCT02721069] | Phase 3 | 175 participants (Actual) | Interventional | 2016-04-11 | Completed | ||
| Non-inferiority Prospective Randomized Trial of Acetazolamide Versus Diazepam in Patients With Continuous Spike and Wave in Sleep (CSWS)/Landau Kleffner Syndrome (LKS)[NCT02904265] | Phase 2/Phase 3 | 3 participants (Actual) | Interventional | 2016-09-30 | Terminated (stopped due to Lack of enrollment) | ||
| Big Data Construction and Biological Etiological Epidemiology Study of Children Epilepsy in China[NCT02969213] | 10,000 participants (Anticipated) | Observational | 2016-11-30 | Not yet recruiting | |||
| A Phase 3, Randomized, Double-blind, Parallel, Placebo-controlled, Multicenter Study, With Optional Open-label Continuation, Of The Efficacy And Safety Of Vanquix(tm) Auto-injector (Diazepam Injection) For The Management Of Selected, Refractory, Patients [NCT00319501] | Phase 3 | 234 participants (Actual) | Interventional | 2006-01-31 | Completed | ||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| Intranasal Midazolam Versus Rectal Diazepam for the Home Treatment of Seizure Activity in Pediatric Patients With Epilepsy[NCT00326612] | Phase 2 | 358 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| Trial of Intracerebral Infusion in Patients With Medically Intractable Epilepsy[NCT00005925] | Phase 1 | 3 participants (Actual) | Interventional | 2000-06-23 | Terminated | ||
| Rapid Oral Treatment of Cluster Epileptic Seizures. Efficacy Assessment of Levetiracetam in Cluster Seizures.[NCT00376766] | Phase 3 | 112 participants (Anticipated) | Interventional | 2007-02-28 | Terminated (stopped due to recruitment recruitment recruitment recruitment difficulties) | ||
| NEED: Neuromed Epilepsy EEG Database. A Large Database of Electroencephalographic (EEG) Signals of Epilepsy Patients for Research Community.[NCT04647825] | 200 participants (Anticipated) | Observational | 2021-04-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Evaluate the pharmacokinetics (PK), in terms of Cmax, of diazepam following a single intranasal dose of NRL-1 (diazepam nasal spray) administered to epilepsy subjects in the ictal or peri-ictal state (defined as either during or immediately following a seizure), where the seizure involved motor activity or alteration of awareness compared with the normal (non-seizing) state. The epileptic condition (ictal/peri-ictal, interictal) had minimal impact on diazepam nasal spray pharmacokinetics. (NCT02724423)
Timeframe: Blood samples were obtained at 0, 15, 30, and 45 minutes, and 1, 1.25, 1.5, 1.75, 2, 3, 4, 5, and 6 hours after dosing. If feasible, samples were drawn at 8 and 12 hours post-dose but were excluded from PK analysis.
| Intervention | ng/mL (Geometric Mean) |
|---|---|
| NRL-1 ICTAL/PERI-ICTAL | 135 |
| NRL-1 INTER-ICTAL | 153 |
Evaluate the pharmacokinetics (PK), in terms of AUC, of diazepam following a single intranasal dose of NRL-1 (diazepam nasal spray) administered to epilepsy subjects in the ictal or peri-ictal state (defined as either during or immediately following a seizure), where the seizure involved motor activity or alteration of awareness compared with the normal (non-seizing) state. The epileptic condition (ictal/peri-ictal, interictal) had minimal impact on diazepam nasal spray pharmacokinetics. (NCT02724423)
Timeframe: Blood samples were obtained at 0, 15, 30, and 45 minutes, and 1, 1.25, 1.5, 1.75, 2, 3, 4, 5, and 6 hours after dosing. If feasible, samples were drawn at 8 and 12 hours post-dose but were excluded from PK analysis.
| Intervention | ng*hr/mL (Geometric Mean) |
|---|---|
| NRL-1 ICTAL/PERI-ICTAL | 435 |
| NRL-1 INTER-ICTAL | 502 |
Assess the number of participants who received at least one dose of NRL-1 (Valtoco) during the study and comprised the safety population. (NCT02721069)
Timeframe: 12 months
| Intervention | Participants (Count of Participants) |
|---|---|
| NRL-1 5mg | 9 |
| NRL-1 10mg | 54 |
| NRL-1 15 mg | 46 |
| NRL-1 20mg | 54 |
Expect improved side effect profile of acetazolamide compared to diazepam at short-term follow up (NCT02904265)
Timeframe: 4-8 weeks of start of medications
| Intervention | Participants (Count of Participants) |
|---|---|
| Diazepam | 1 |
| Acetazolamide | 2 |
Caregiver global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes and is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) is defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: Assessments completed at the end of each treated episode of ARS in the Double-blind Period
| Intervention | Units on a scale (Mean) |
|---|---|
| Diazepam | 6.2 |
| Placebo | 5.5 |
Caregiver global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes and is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) is defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: Assessments completed at the end of each treated episode of ARS in the Open-label Period
| Intervention | Units on a scale (Mean) |
|---|---|
| Diazepam | 6.78 |
Physician global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes. The physician global evaluation is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: At Visit 2 and subsequent visits in the Double-blind Period
| Intervention | Units on a scale (Mean) |
|---|---|
| Diazepam | 6.3 |
| Placebo | 5.5 |
Physician global evaluation is based on seizure frequency, severity, and overall outcome compared with previous episodes and is rated on a 10-cm visual analogue scale, where 0=much worse and 10=much better. A higher score indicates greater improvement. An episode of acute repetitive seizures (ARS) is defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From Visit 2 and subsequent visits in the Open-label Period to discharge or study termination
| Intervention | Units on a scale (Mean) |
|---|---|
| Diazepam | 6.87 |
Any use of emergency treatment (such as an emergency room visit) was recorded in the patient's diary, along with the date, time, and reason for the emergency treatment. Emergency department visits required some type of rescue action taken, other than the visit itself. An episode of acute repetitive seizures (ARS) was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From 15 minutes to 12 hours following study drug administration for onset of an episode of ARS during the Double-blind Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 2 |
| Placebo | 4 |
Any use of emergency treatment (such as an emergency room visit) was recorded in the patient's diary, along with the date, time, and reason for the emergency treatment. Emergency department visits required some type of rescue action taken, other than the visit itself. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for onset of an episode of ARS during the Open-label Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 13 |
Other rescue medical care consisted of care other than rescue medication or emergency department visits. Each patient's specific criteria for seizure and an episode of acute repetitive seizure (ARS) were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for onset of an episode of ARS during the Open-label Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 5 |
Other rescue medical care consisted of care other than rescue medication or emergency department visits. Each patient's specific criteria for seizure and an episode of acute repetitive seizure (ARS) were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. An episode of ARS was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From 15 minutes to 12 hours following study drug administration for an episode of ARS during the Double-blind Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 0 |
| Placebo | 2 |
If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the acute repetitive seizure (ARS) episode. Each patient's specific criteria for seizure and an episode of ARS were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. An episode of ARS was defined as an episode of multiple complex, partial, or generalized seizures occurring over a brief period (minutes to 12 hours) with the patient regaining consciousness between seizures, which were readily recognizable by the patient or a trained caregiver. ARS includes seizures sometimes referred to as serial, cluster, crescendo, or stuttering prolonged. (NCT00319501)
Timeframe: From 15 minutes to 12 hours following study drug administration for an episode of ARS during the Double-blind Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 14 |
| Placebo | 24 |
Each patient's specific criteria for seizure and an episode of acute repetitive seizure (ARS) were determined by the Investigator. Patients and their caregivers were trained to use these criteria to recognize the onset of an episode of ARS and when and how to administer study drug. If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the ARS episode. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration during the Open-label Period
| Intervention | Participants (Number) |
|---|---|
| Diazepam | 39 |
An event was defined as an episode of or required rescue medication for an episode of acute repetitive seizures (ARS) within 15 minutes to 12 hours following study drug administration. Patients without an ARS event were censored at 12 hours. Diaries were provided; if no diary was returned, or the diary did not provide answers to questions about seizures and rescue during the 12-hour follow-up period, the patient was considered censored as of 15 minutes past the treatment time, unless another contact was documented. If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the ARS episode. Patients and their caregivers were trained to recognize the onset of an episode of ARS and when and how to administer study drug. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for an episode of ARS during the Double-blind Period
| Intervention | Percentage of participants (Number) |
|---|---|
| Diazepam | 22.4 |
An event was defined as an episode of or required rescue medication for an episode of acute repetitive seizures (ARS) within 15 minutes to 12 hours following study drug administration. Patients without an ARS event were censored at 12 hours. Diaries were provided; if no diary was returned, or the diary did not provide answers to questions about seizures and rescue during the 12-hour follow-up period, the patient was considered censored as of 15 minutes past the treatment time, unless another contact was documented. If seizure control following study drug administration was inadequate, diazepam rectal gel was provided as a rescue medication, given only in the first 4 hours after study drug administration and only if the caregiver was directed to do so by the Investigator or designee at the time of the ARS episode. Patients and their caregivers were trained to recognize the onset of an episode of ARS and when and how to administer study drug. (NCT00319501)
Timeframe: From 15 minutes to 12 hours after study drug administration for an episode of ARS during the Double-blind Period
| Intervention | Hours (Median) |
|---|---|
| Diazepam | 5.92 |
| Placebo | NA |
Length of seizure. (NCT00326612)
Timeframe: 24 hours
| Intervention | Minutes (Median) |
|---|---|
| Intranasal Midazolam | 3.0 |
| Rectal Diazepam | 4.3 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 21 |
| Rectal Diazepam | 17 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 4 |
| Rectal Diazepam | 3 |
(NCT00326612)
Timeframe: 12 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 1 |
(NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 5 |
| Rectal Diazepam | 5 |
Respiratory depression was defined as intubation at Emergency Department discharge. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 1 |
| Rectal Diazepam | 0 |
Respiratory depression was defined as requiring oxygen at discharge from the Emergency Department. (NCT00326612)
Timeframe: 24 hours
| Intervention | participants (Number) |
|---|---|
| Intranasal Midazolam | 3 |
| Rectal Diazepam | 1 |
56 reviews available for diazepam and Aura
| Article | Year |
|---|---|
Rescue therapies in epilepsy.
Topics: Administration, Intranasal; Adult; Anticonvulsants; Diazepam; Epilepsy; Humans; Seizures | 2022 |
Effects of common antiepileptic drugs on teleost fishes.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Ecosystem; Epilepsy; Fishes; Humans | 2023 |
Effects of tranquilization therapy in elderly patients suffering from chronic non-communicable diseases: A meta-analysis.
Topics: Aged; Diazepam; Epilepsy; Humans; Noncommunicable Diseases; Prospective Studies; Randomized Controll | 2023 |
Second Generation of Antiepileptic Drugs and Oxidative Stress.
Topics: Anticonvulsants; Carbamazepine; Diazepam; Epilepsy; Epilepsy, Generalized; Fructose; Gabapentin; Hum | 2023 |
Overcoming barriers to the management of seizure clusters: ease of use and time to administration of rescue medications.
Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Epilepsy; Epilepsy, Generalized; Humans; Nasa | 2023 |
Acute Abortive Therapies for Seizure Clusters in Long-Term Care.
Topics: Aged; Anticonvulsants; Diazepam; Epilepsy; Humans; Long-Term Care; Status Epilepticus; United States | 2023 |
Seizure Rescue Medications for Out-Of-Hospital Use in Children.
Topics: Administration, Intranasal; Administration, Rectal; Anticonvulsants; Benzodiazepines; Child; Diazepa | 2021 |
Safety and efficacy of diazepam autoinjector for the management of epilepsy.
Topics: Acute Disease; Administration, Buccal; Animals; Anticonvulsants; Diazepam; Epilepsy; Humans | 2015 |
Anti-glutamic acid decarboxylase antibody positive neurological syndromes.
Topics: Autoantibodies; Baclofen; Cerebellar Ataxia; Diazepam; Epilepsy; GABA Modulators; GABA-B Receptor Ag | 2016 |
[Diagnosis and treatment of epilepsy in the field of psychiatry].
Topics: Adult; Anticonvulsants; Carbamazepine; Diazepam; Electroencephalography; Epilepsy; Female; Humans; M | 2008 |
[Alcohol and epilepsy].
Topics: Alcohol Drinking; Alcohol Withdrawal Seizures; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; | 2003 |
Safety of Diastat, a rectal gel formulation of diazepam for acute seizure treatment.
Topics: Acute Disease; Administration, Rectal; Anticonvulsants; Diazepam; Epilepsy; Gels; Humans | 2004 |
[Febrile seizures--an update].
Topics: Administration, Oral; Administration, Rectal; Age Factors; Analgesics, Non-Narcotic; Anticonvulsants | 2004 |
Emergency management of seizures in the school setting.
Topics: Administration, Rectal; Anticonvulsants; Child; Diazepam; Emergencies; Epilepsy; Humans; Nursing Rec | 2007 |
[Benzodiazepines in the treatment of epilepsy].
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Child, Preschool; Clobazam | 1983 |
[Use of phenobarbital in febrile convulsive crisis].
Topics: Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Nervous System Diseases; Phenobarbital; Recurr | 1983 |
Pharmacological principles in the long-term treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Kinetics; Long | 1981 |
Seizure disorders.
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Mephob | 1980 |
Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: etiology, outcome, and treatment.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Benzodiazepines; Central Nervous System Disea | 1996 |
Seizures in dogs.
Topics: Animals; Anticonvulsants; Diagnosis, Differential; Diazepam; Dog Diseases; Dogs; Epilepsy; Phenobarb | 1996 |
New drug therapy for acute seizure management.
Topics: Acute Disease; Anticonvulsants; Child; Diazepam; Epilepsy; Humans; Phenytoin; Prodrugs; Seizures; Va | 1997 |
Management and treatment of febrile seizures.
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Blood Chemical Analysis; Child, Preschool; Diagnosis, Dif | 1997 |
Advances in the medical treatment of epilepsy.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Diazepam; Drug Approv | 1998 |
[Rectal diazepam for treatment and prevention of seizures in children].
Topics: Administration, Rectal; Anticonvulsants; Child; Diagnosis, Differential; Diazepam; Epilepsy; Humans; | 1998 |
Antiepileptic drug therapy.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Cat Diseases; Cats; Cyclohexanecarboxylic Acid | 1998 |
Seizure management in pediatric patients for the nineties.
Topics: Age Factors; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; F | 1998 |
Febrile seizures: treatment and prognosis.
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Cognition; Diazepam; Epilepsy; Humans; Intelligence; Prog | 2000 |
New antiepileptic drugs and preparations.
Topics: Acetates; Administration, Rectal; Age Factors; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; | 2000 |
[Febrile convulsions, Treatment and prognosis].
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe | 2001 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
Minor tranquilizers in the treatment of aggression.
Topics: Aggression; Animals; Anti-Anxiety Agents; Anxiety; Chlordiazepoxide; Depression; Diazepam; Epilepsy; | 1975 |
[Prevention of recurrences and of epilepsy in febrile convulsions. Protocol of the Pediatric Clinic of the Florence and preliminary results].
Topics: Age Factors; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; | 1979 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
Management of seizure disorders: selected aspects. Part I.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Child; Chromatography, Gas; Chromatography, | 1976 |
Neurologic disorders in renal failure (first of two parts).
Topics: Blood-Brain Barrier; Brain Diseases; Cerebrospinal Fluid Proteins; Diazepam; Epilepsy; Humans; Lidoc | 1976 |
[Epileptic psychoses and their drug treatment].
Topics: Anticonvulsants; Antipsychotic Agents; Clonazepam; Diazepam; Epilepsy; Humans; Neurocognitive Disord | 1989 |
A sound basis for the use of benzodiazepines.
Topics: Anesthesia; Anti-Anxiety Agents; Anxiety Disorders; Diazepam; Drug Utilization; Epilepsy; Humans; In | 1985 |
Febrile seizures.
Topics: Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Female | 1987 |
Use of barbiturates and benzodiazepines in treatment of epilepsy.
Topics: Adult; Barbiturates; Benzodiazepines; Child; Clonazepam; Clorazepate Dipotassium; Diazepam; Epilepsy | 1986 |
Pharmacokinetics of anti-epileptic drugs in the dog: a review.
Topics: Animals; Anticonvulsants; Blood Proteins; Carbamazepine; Clonazepam; Diazepam; Dog Diseases; Dogs; E | 1985 |
Usefulness of blood levels of antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chloramphenicol; Chlordiazepoxide; Chlorpromazine; Chromatography, G | 1974 |
[Psychopharmacological agents in children].
Topics: Acetylcholine; Aminobutyrates; Antipsychotic Agents; Cerebral Palsy; Child; Chlordiazepoxide; Diazep | 1973 |
Plasma levels of anticonvulsants.
Topics: Administration, Oral; Adult; Animals; Anticonvulsants; Barbiturates; Blood Proteins; Carbamazepine; | 1973 |
Benzodiazepines in the treatment of epilepsy. A review.
Topics: Adult; Animals; Anticonvulsants; Chlordiazepoxide; Diazepam; Disease Models, Animal; Eclampsia; Elec | 1973 |
[Diagnosis and treatment of epilepsy].
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Age Factors; Aged; Anticoag | 1968 |
A basic approach to the understanding of seizures and the mechanism of action and metabolism of anticonvulsants.
Topics: Acetylcholine; Aminobutyrates; Anticonvulsants; Calcium; Cell Membrane Permeability; Depression, Che | 1973 |
Toxic effects of anticonvulsants: general principles.
Topics: Adrenocorticotropic Hormone; Adult; Anticonvulsants; Benzodiazepinones; Body Surface Area; Body Weig | 1974 |
Epilepsy.
Topics: Adolescent; Animals; Barbiturates; Brain Neoplasms; Cell Membrane Permeability; Central Nervous Syst | 1968 |
Recent progress in epilepsy. Diagnostic procedures and treatment.
Topics: Anticonvulsants; Brain Neoplasms; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Temporal Lob | 1973 |
The benzodiazepines.
Topics: Alcoholism; Anesthesia; Animals; Antidepressive Agents; Benzazepines; Diazepam; Epilepsy; Heart Dise | 1973 |
[Features of the clinical effect of benzodiazepine derivatives (according to the findings of comparative studies). Review of the literature].
Topics: Adjustment Disorders; Aggression; Animals; Antisocial Personality Disorder; Barbiturates; Benzazepin | 1973 |
The treatment of status epilepticus.
Topics: Anti-Bacterial Agents; Anticonvulsants; Barbiturates; Brain Edema; Central Nervous System Diseases; | 1974 |
The value of EEG study in minimal brain dysfunction.
Topics: Attention Deficit Disorder with Hyperactivity; Child Behavior Disorders; Chlordiazepoxide; Diagnosis | 1974 |
Convulsions in children.
Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Ethosuximide; Humans; Infant; M | 1968 |
[Recent developments in psychopharmacology].
Topics: Antidepressive Agents; Barbiturates; Bipolar Disorder; Chlormethiazole; Depression; Diazepam; Electr | 1968 |
[General review of the present therapy of epilepsy].
Topics: Anticonvulsants; Barbiturates; Chlordiazepoxide; Diazepam; Epilepsy; Humans; Hydantoins; Phenobarbit | 1971 |
40 trials available for diazepam and Aura
| Article | Year |
|---|---|
Safety of Diazepam Nasal Spray in Children and Adolescents With Epilepsy: Results From a Long-Term Phase 3 Safety Study.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Anticonvulsants; Child; Diazepam; Double-Blind | 2022 |
Concomitant cannabidiol does not impact safety and effectiveness of diazepam nasal spray for seizure clusters: Post hoc analysis of a phase 3 safety study.
Topics: Anticonvulsants; Cannabidiol; Diazepam; Epilepsy; Humans; Nasal Sprays; Seizures; Treatment Outcome | 2023 |
Safety of Diazepam Nasal Spray in Pediatric Patients With Developmental Epileptic Encephalopathies: Results From a Long-term Phase 3 Safety Study.
Topics: Anticonvulsants; Brain Diseases; Child; Diazepam; Epilepsy; Epilepsy, Generalized; Humans; Lennox Ga | 2023 |
Pharmacokinetics and safety of VALTOCO (NRL-1; diazepam nasal spray) in patients with epilepsy during seizure (ictal/peri-ictal) and nonseizure (interictal) conditions: A phase 1, open-label study.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Child; Diazepam; Epilepsy; Female; Humans; Male | 2020 |
Safety and tolerability associated with chronic intermittent use of diazepam buccal film in adult, adolescent, and pediatric patients with epilepsy.
Topics: Administration, Buccal; Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Diazepam; | 2020 |
Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long-term, open-label safety study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Diazepam; Dru | 2021 |
Lack of observed tolerance to diazepam nasal spray (Valtoco®) after long-term rescue therapy in patients with epilepsy: Interim results from a phase 3, open-label, repeat-dose safety study.
Topics: Administration, Intranasal; Diazepam; Epilepsy; Humans; Nasal Sprays; Seizures; Treatment Outcome | 2021 |
Consistent safety and tolerability of Valtoco
Topics: Administration, Intranasal; Diazepam; Epilepsy; Humans; Nasal Sprays; Seizures | 2021 |
Final results from a Phase 3, long-term, open-label, repeat-dose safety study of diazepam nasal spray for seizure clusters in patients with epilepsy.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Anticonvulsants; Brain Damage, Chronic; Child; | 2021 |
A double-blind, randomized, placebo-controlled trial of a diazepam auto-injector administered by caregivers to patients with epilepsy who require intermittent intervention for acute repetitive seizures.
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Caregivers; Child; Child, Preschool; Diazepam; Do | 2013 |
Phenobarbital Versus Valproate for Generalized Convulsive Status Epilepticus in Adults: A Prospective Randomized Controlled Trial in China.
Topics: Administration, Intravenous; Adult; Anticonvulsants; China; Diazepam; Epilepsy; Female; Humans; Male | 2016 |
Acute administration of benzodiazepines as part of treatment strategies for epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Benzodiazepines; Clobazam; Diazepam; Dr | 2011 |
Intranasal midazolam vs rectal diazepam for the home treatment of acute seizures in pediatric patients with epilepsy.
Topics: Acute Disease; Administration, Intranasal; Administration, Rectal; Anticonvulsants; Child; Child, Pr | 2010 |
Valproate versus diazepam for generalized convulsive status epilepticus: a pilot study.
Topics: Adult; Aged; Anticonvulsants; Cerebrovascular Disorders; Diazepam; Drug Resistance; Electroencephalo | 2011 |
Intranasal midazolam vs rectal diazepam in acute childhood seizures.
Topics: Acute Disease; Administration, Intranasal; Anticonvulsants; Child; Child, Preschool; Diazepam; Epile | 2006 |
A clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Clinical Trials as Topic; Diazepam | 1984 |
Absorption of diazepam from the rectum and its effect on interictal spikes in the EEG.
Topics: Adolescent; Adult; Diazepam; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Intestinal | 1982 |
[Administration of a single oral high-dose of diazepam at bedtime as therapy for intractable seizures].
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Foll | 1995 |
Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus.
Topics: Administration, Rectal; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Injections, Intravenou | 1995 |
Bioavailability of benzodiazepines following rectal administration of diazepam in dogs.
Topics: Administration, Rectal; Animals; Biological Availability; Cross-Over Studies; Diazepam; Dog Diseases | 1995 |
Long term outcome of prophylaxis for febrile convulsions.
Topics: Adolescent; Anticonvulsants; Child; Child Development; Cognition; Diazepam; Epilepsy; Follow-Up Stud | 1996 |
Is ACTH a key to understanding anticonvulsant action?
Topics: Adenosine; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Binding Sites; Child; Chil | 1998 |
A comparison of rectal diazepam gel and placebo for acute repetitive seizures.
Topics: Acute Disease; Administration, Rectal; Adolescent; Adult; Child; Child, Preschool; Diazepam; Disease | 1998 |
[Treatment for generalized seizures: the best of four methods].
Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Lorazepam; Phenobarbital; Phenytoin | 1999 |
Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group.
Topics: Acute Disease; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepa | 1999 |
An open-label study of repeated use of diazepam rectal gel (Diastat) for episodes of acute breakthrough seizures and clusters: safety, efficacy, and tolerance. North American Diastat Group.
Topics: Administration, Rectal; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Child, Prescho | 1999 |
The effect of intravenous flumazenil on interictal electroencephalographic epileptic activity: results of a placebo-controlled study.
Topics: Adult; Anticonvulsants; Brain; Diazepam; Dose-Response Relationship, Drug; Drug Therapy, Combination | 1991 |
Intermittent diazepam prophylaxis in febrile convulsions. Pros and cons.
Topics: Behavior; Child, Preschool; Diazepam; Drug Administration Schedule; Epilepsy; Humans; Infant; Patien | 1991 |
The effect of lamotrigine, a novel anticonvulsant, on interictal spikes in patients with epilepsy.
Topics: Adult; Anticonvulsants; Clinical Trials as Topic; Diazepam; Double-Blind Method; Electroencephalogra | 1986 |
Effective short-term diazepam prophylaxis in febrile convulsions.
Topics: Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Male; Patient Compliance; Random Alloc | 1985 |
The use of diazepam in the control of status epilepticus.
Topics: Clinical Trials as Topic; Diazepam; Electroencephalography; Epilepsy; Humans | 1968 |
Comparative trial of diazepam and pheneturide in treatment of epilepsy.
Topics: Age Factors; Diazepam; Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Male; Stress, Psychologica | 1969 |
Treatment of hypsarrhythmia and infantile spasms with a librium analogue.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Child, Preschool; Chlordiazepoxide; Clinical Tr | 1965 |
[An original psychotropic drug: sulpiride].
Topics: Adult; Animals; Anxiety; Behavior; Clinical Trials as Topic; Cognition Disorders; Delirium; Depressi | 1969 |
Studies with new drugs in the treatment of convulsive disorders.
Topics: Adult; Aggression; Anticonvulsants; Anxiety; Carbamazepine; Clinical Trials as Topic; Diazepam; Dibe | 1968 |
Effect of minor and major tranquilizers on somatosensory evoked potentials.
Topics: Administration, Oral; Adult; Benzazepines; Chlordiazepoxide; Chlorpromazine; Clinical Trials as Topi | 1972 |
[Clinico-experimental studies in the treatment of epilepsy with GABOB-diazepam].
Topics: Adolescent; Adult; Aminobutyrates; Child; Clinical Trials as Topic; Diazepam; Drug Combinations; Ele | 1973 |
Clinical experience with clonazepam (Rivotril) in the treatment of epilepsies in infancy and childhood.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Benzodiazepinones; Child; Child, Preschool; Chlor | 1973 |
Acute treatment of epileptic seizures with diazepamum (Valium).
Topics: Acute Disease; Adolescent; Adult; Aged; Aphasia; Clinical Trials as Topic; Diazepam; Epilepsy; Epile | 1967 |
Treatment of status epilepticus with diazepam.
Topics: Child; Child, Preschool; Clinical Trials as Topic; Diazepam; Electroencephalography; Epilepsy; Femal | 1966 |
434 other studies available for diazepam and Aura
| Article | Year |
|---|---|
Synthesis of gem-difluoro-avermectin derivatives: potent anthelmintic and anticonvulsant agents.
Topics: Animals; Anthelmintics; Anticonvulsants; Epilepsy; Ivermectin; Mice; Molecular Structure | 1998 |
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Inhibiting with-no-lysine kinases enhances K+/Cl- cotransporter 2 activity and limits status epilepticus.
Topics: Animals; Diazepam; Epilepsy; Hippocampus; Humans; Lysine; Mice; Mice, Inbred C57BL; Rats; Status Epi | 2022 |
Evaluation of Resveratrol and Piceatannol Anticonvulsant Potential in Adult Zebrafish (Danio rerio).
Topics: Animals; Anticonvulsants; Caspase 3; Diazepam; Epilepsy; Interleukin-1beta; Neuroprotective Agents; | 2022 |
Use of new intranasal benzodiazepines at a typical adult epilepsy center.
Topics: Administration, Intranasal; Adult; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Epilepsy, G | 2022 |
Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters.
Topics: Administration, Intranasal; Adult; Anticonvulsants; Brain Damage, Chronic; Diazepam; Epilepsy; Epile | 2022 |
Aerobic exercise, alone or combined with an anti-inflammatory drug, reduces the severity of epileptic seizures and levels of central pro-inflammatory cytokines in an animal model of epileptic seizures.
Topics: Animals; Anti-Inflammatory Agents; Cytokines; Diazepam; Disease Models, Animal; Epilepsy; Exercise; | 2022 |
Esculetin alleviates pentylenetetrazole-induced seizures, cognitive impairment and pro-inflammatory cytokines and suppresses penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Cognitive Dysfunction; Cytokines; Diazepam; Disease Models, Animal; Epilep | 2023 |
Synergistic effects of applying static magnetic fields and diazepam to improve EEG abnormalities in the pilocarpine epilepsy rat model.
Topics: Animals; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy; Magnetic Fields; Piloca | 2023 |
Epileptic Status in a PEDiatric cohort (ESPED) requiring intensive care treatment: A multicenter, national, two-year prospective surveillance study.
Topics: Adolescent; Anticonvulsants; Child; Critical Care; Diazepam; Epilepsy; Female; Humans; Male; Midazol | 2023 |
CRISPR-Based KCC2 Upregulation Attenuates Drug-Resistant Seizure in Mouse Models of Epilepsy.
Topics: Animals; Calcium; Diazepam; Epilepsy; Hippocampus; Kainic Acid; Mice; Pharmaceutical Preparations; S | 2023 |
Neurofilament light chain: A possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy?
Topics: Animals; Biomarkers; Diazepam; Epilepsy; Intermediate Filaments; Kainic Acid; Ketamine; Mice; Neurof | 2023 |
Sublingual lorazepam as rescue therapy for seizure emergencies in adults.
Topics: Adult; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Lorazepam; Retrospective Studies; S | 2023 |
Utilization of Antiseizure Medications in Women of Childbearing Age With Epilepsy and Nonepilepsy Indications: A Retrospective Cohort Study.
Topics: Anticonvulsants; Clonazepam; Diazepam; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Lorazepam; | 2023 |
Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Child, Preschool; Diazepam; Drug Resistance; Drug Resista | 2019 |
Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy.
Topics: Amino Acid Sequence; Child; Chloride Channels; Diazepam; Electroencephalography; Epilepsy; Female; G | 2019 |
Diagnostic evaluation and management of seizures and status epilepticus in children with known epilepsy or new-onset seizures: A retrospective and comparative analysis.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Clonazepam; Diazepam; Epilepsy; Female; Hospit | 2020 |
A novel de novo variant of GABRA1 causes increased sensitivity for GABA in vitro.
Topics: Child; Developmental Disabilities; Diazepam; Epilepsy; GABA Modulators; gamma-Aminobutyric Acid; HEK | 2020 |
Intranasal diazepam (Valtoco) and midazolam (Nayzilam) for seizure clusters.
Topics: Administration, Intranasal; Anticonvulsants; Diazepam; Epilepsy; Humans; Midazolam; Seizures | 2020 |
Anticonvulsant effects of the aqueous and methanol extracts from the stem bark of Psychotria camptopus Verdc. (Rubiacaea) in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Diazepam; Disease Models, Animal; Epilepsy; Methanol; Mi | 2021 |
Intra-hippocampal microinjection of oxytocin produced antiepileptic effect on the pentylenetetrazol-induced epilepsy in rats.
Topics: Animals; Anticonvulsants; Diazepam; Epilepsy; Flumazenil; Hippocampus; Male; Microinjections; Oxytoc | 2017 |
Anticonvulsant effects of thiamine on pentylenetetrazole-induced seizure in mice.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Epilep | 2019 |
Healthcare Utilization Characteristics for Intranasal Midazolam Versus Rectal Diazepam.
Topics: Administration, Intranasal; Administration, Rectal; Adolescent; Adult; Ambulatory Care; Anticonvulsa | 2018 |
Effect of rescue medication on seizure duration in non-institutionalized children with epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Male; Mida | 2018 |
Experimental Substantiation of Inhalation Administration of Pathogenic Therapy of Toxic Convulsive Disorder for Correction of External Respiration Disorders.
Topics: Administration, Inhalation; Albuterol; Animals; Atropine; Bronchodilator Agents; Convulsants; Diazep | 2018 |
[Patent rickets disclosed by loss of convulsion control in a boy with cerebral palsy].
Topics: Anticonvulsants; Calcium; Carbamazepine; Cerebral Palsy; Child, Preschool; Diazepam; Epilepsy; Human | 2013 |
The cost effectiveness of licensed oromucosal midazolam (Buccolam(®)) for the treatment of children experiencing acute epileptic seizures: an approach when trial evidence is limited.
Topics: Acute Disease; Administration, Buccal; Administration, Rectal; Child; Cost-Benefit Analysis; Decisio | 2013 |
GABAergic tonic inhibition is regulated by developmental age and epilepsy in the dentate gyrus.
Topics: Aging; Animals; Anticonvulsants; Data Interpretation, Statistical; Dentate Gyrus; Diazepam; Electrop | 2013 |
Long-term response to high-dose diazepam treatment in continuous spikes and waves during sleep.
Topics: Adolescent; Anticonvulsants; Brain Waves; Child; Child, Preschool; Diazepam; Dose-Response Relations | 2013 |
Feasibility study of a caregiver seizure alert system in canine epilepsy.
Topics: Algorithms; Animals; Anticonvulsants; Caregivers; Chromatography, High Pressure Liquid; Clinical Ala | 2013 |
A patient with progressive cognitive decline and periodic abnormal waves in EEG: PLEDs of neurosyphilis or PSDs of Creutzfeldt-Jakob disease?
Topics: Atrophy; China; Coma; Creutzfeldt-Jakob Syndrome; Dementia; Diagnosis, Differential; Diazepam; Diffu | 2014 |
Epilepsy in kcnj10 morphant zebrafish assessed with a novel method for long-term EEG recordings.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Electroencephalograp | 2013 |
Episodic epileptic verbal auditory agnosia in Landau Kleffner syndrome treated with combination diazepam and corticosteroids.
Topics: Adrenal Cortex Hormones; Agnosia; Anticonvulsants; Brain; Child; Child, Preschool; Diazepam; Electro | 2014 |
Prognostic factors for acute encephalopathy with bright tree appearance.
Topics: Acute Disease; Anti-Anxiety Agents; Brain; Brain Diseases; Child; Child, Preschool; Creatinine; Diaz | 2015 |
[Electrophysiology of intractable childhood epilepsy].
Topics: Brain; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; gamma-Aminobutyric Acid; | 2014 |
Effects of intracortical microinjection of vitamin B12 on penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Benzodiazepines; Diazepam; Electroencephalography; Epilepsy; Male; Microin | 2015 |
Alterations in hippocampal myelin and oligodendrocyte precursor cells during epileptogenesis.
Topics: Animals; Cell Differentiation; Diazepam; Disease Models, Animal; Epilepsy; Hippocampus; Muscarinic A | 2015 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Effect of diclofenac sodium on seizures and inflammatory profile induced by kindling seizure model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cerebral Cortex; Diazepam; Diclof | 2016 |
Response to diazepam in children with malaria-induced seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Female; Histidine; Humans; Infant; Inj | 2008 |
Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis.
Topics: Amygdala; Animals; Diazepam; Epilepsy; Hippocampus; Male; Nerve Degeneration; Random Allocation; Rat | 2010 |
Validation of anticonvulsant and sedative activity of six medicinal plants.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Electroshock; Epi | 2009 |
Diazepam and pentobarbital protect against scorpion venom toxin-induced epilepsy.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Count; Cell Death; Diazepam; Electroencephalogr | 2009 |
Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways.
Topics: Animals; Anticonvulsants; Cyproheptadine; Diazepam; Disease Models, Animal; Dose-Response Relationsh | 2009 |
Altered responses of dopamine D3 receptor null mice to excitotoxic or anxiogenic stimuli: Possible involvement of the endocannabinoid and endovanilloid systems.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; Anxiety | 2009 |
Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide.
Topics: Acetamides; Adult; Anticonvulsants; Diazepam; Drug Resistance; Drug Therapy, Combination; Epilepsy; | 2010 |
Guidelines for diagnosis and management of childhood epilepsy.
Topics: Algorithms; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Hu | 2009 |
Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome.
Topics: Action Potentials; Bumetanide; Cerebral Cortex; Diazepam; Epilepsy; Excitatory Amino Acid Antagonist | 2009 |
A comparison of midazolam nasal spray and diazepam rectal solution for the residential treatment of seizure exacerbations.
Topics: Acute Disease; Administration, Intranasal; Administration, Rectal; Benzodiazepines; Diazepam; Drug A | 2010 |
Qualitative analysis of hippocampal plastic changes in rats with epilepsy supplemented with oral omega-3 fatty acids.
Topics: Administration, Oral; Animals; Anticonvulsants; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine | 2010 |
Anticonvulsant activity of DNS II fraction in the acute seizure models.
Topics: Acetone; Animals; Anticonvulsants; Delphinium; Diazepam; Epilepsy; Male; Melanoma; Mice; Mice, Inbre | 2010 |
Migraine triggered by epileptic discharges in a Rasmussen's encephalitis patient after surgery.
Topics: Adolescent; Anticonvulsants; Child; Diazepam; Electroencephalography; Encephalitis; Epilepsy; Humans | 2011 |
Treatment gap for people living with epilepsy in Madagascar.
Topics: Anticonvulsants; Barbiturates; Delivery of Health Care; Developing Countries; Diazepam; Drug Therapy | 2011 |
Rectal diazepam solution is as good as rectal administration of intravenous diazepam in the first-aid cessation of seizures in children with intractable epilepsy.
Topics: Administration, Rectal; Adolescent; Anticonvulsants; Chi-Square Distribution; Child; Child, Preschoo | 2011 |
Bone marrow mononuclear cells reduce seizure frequency and improve cognitive outcome in chronic epileptic rats.
Topics: Animals; Bone Marrow Cells; Cell Transplantation; Chronic Disease; Cognition Disorders; Diazepam; Di | 2011 |
A cell-free extract from human adipose stem cells protects mice against epilepsy.
Topics: Adipose Tissue; Animals; Animals, Newborn; Anticonvulsants; Blood-Brain Barrier; Cell Extracts; Cell | 2011 |
Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype.
Topics: Adaptor Proteins, Signal Transducing; Animals; Biocatalysis; Diazepam; Electroencephalography; Epile | 2012 |
Neuregulin 1 represses limbic epileptogenesis through ErbB4 in parvalbumin-expressing interneurons.
Topics: Analysis of Variance; Animals; Anticonvulsants; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 2011 |
A mouse kindling model of perimenstrual catamenial epilepsy.
Topics: 5-alpha Reductase Inhibitors; Animals; Diazepam; Disease Models, Animal; Epilepsy; Female; Finasteri | 2012 |
Statistical parametric mapping reveals regional alterations in cannabinoid CB1 receptor distribution and G-protein activation in the 3D reconstructed epileptic rat brain.
Topics: Animals; Anticonvulsants; Benzoxazines; Brain; Brain Mapping; Diazepam; Disease Models, Animal; Epil | 2012 |
Central effect of crocin on penicillin-induced epileptiform activity in rats.
Topics: Animals; Anticonvulsants; Brain; Carotenoids; Diazepam; Disease Models, Animal; Dose-Response Relati | 2012 |
Evaluation of the sedative and anticonvulsant properties of three Cameroonian plants.
Topics: Administration, Oral; Analysis of Variance; Animals; Anticonvulsants; Cameroon; Diazepam; Dose-Respo | 2011 |
Primary afterdischarge in organotypic hippocampal slice cultures: effects of standard antiepileptic drugs.
Topics: Action Potentials; Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Epilepsy; H | 2012 |
Synthesis and pharmacological investigation of 2-(4-dimethylaminophenyl)-3,5-disubstituted thiazolidin-4-ones as anticonvulsants.
Topics: Acetamides; Animals; Anticonvulsants; Benzamides; Diazepam; Disease Models, Animal; Epilepsy; Male; | 2012 |
Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relationship, | 2012 |
Vagal nerve stimulation in New Zealand: improvement of seizure control following the implantation of a vagal nerve stimulator.
Topics: Adult; Anticonvulsants; Diazepam; Epilepsy; Humans; Male; New Zealand; Vagus Nerve Stimulation | 2012 |
Effects of intravenous diazepam on high-frequency oscillations in EEGs with CSWS.
Topics: Administration, Intravenous; Anticonvulsants; Brain Waves; Child; Child, Preschool; Diazepam; Electr | 2013 |
Hypoxia markers are expressed in interneurons exposed to recurrent seizures.
Topics: Animals; Anticonvulsants; Biomarkers; Cell Hypoxia; Cerebral Cortex; Convulsants; Diazepam; Disease | 2013 |
Piperine decreases pilocarpine-induced convulsions by GABAergic mechanisms.
Topics: Alkaloids; Amino Acids; Animals; Anticonvulsants; Antioxidants; Atropine; Benzodioxoles; Biogenic Mo | 2013 |
Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization.
Topics: Animals; Behavior, Animal; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Response Relat | 2013 |
Characterization of neuronal death induced by focally evoked limbic seizures in the C57BL/6 mouse.
Topics: Analysis of Variance; Animals; Anticonvulsants; Cell Death; Diazepam; Disease Models, Animal; Electr | 2002 |
Altered kinetics and benzodiazepine sensitivity of a GABAA receptor subunit mutation [gamma 2(R43Q)] found in human epilepsy.
Topics: Amino Acid Substitution; Animals; Anti-Anxiety Agents; Cell Line; Diazepam; Epilepsy; Flunitrazepam; | 2002 |
[Epileptic Münchausen syndrome by idiosyncratic of effect antiepileptic drugs].
Topics: Adult; Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Female; Headache; Humans; Muncha | 2003 |
Phenytoin-diazepam interaction.
Topics: Adult; Anticonvulsants; Diazepam; Drug Interactions; Epilepsy; Humans; Male; Phenytoin | 2003 |
Educating lay carers of people with learning disability in epilepsy awareness and in the use of rectal diazepam: a suggested teaching protocol for use by healthcare personnel.
Topics: Administration, Rectal; Anticonvulsants; Caregivers; Diazepam; Epilepsy; Home Health Aides; Humans; | 1999 |
[CLINICAL EVALUATION OF BENZODIAZEPINONE].
Topics: Alcoholism; Diazepam; Epilepsy; Humans; Mental Disorders; Tranquilizing Agents | 1963 |
DIAZEPAM: ITS ROLE IN A PRISON SETTING.
Topics: Adolescent; Diazepam; Epilepsy; Geriatrics; Humans; Mental Disorders; Prisons; Psychotic Disorders; | 1964 |
[CHANGES IN EPILEPTIC ACTIVITY INDUCED BY LOCAL APPLICATION OF STRYCHNINE IN ANIMALS TREATED WITH DERIVATIVES OF BENZODIAZEPINE].
Topics: Benzodiazepines; Chlordiazepoxide; Diazepam; Epilepsy; Pharmacology; Rabbits; Research; Strychnine; | 1963 |
COMPARATIVE STUDY OF CHLORDIAZEPOXIDE AND DIAZEPAM.
Topics: Cerebral Palsy; Chlordiazepoxide; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Int | 1964 |
[CLINICAL STUDY OF VALIUM IN 50 "EPILEPTIC" PATIENTS].
Topics: Adolescent; Biomedical Research; Child; Diazepam; Electroencephalography; Epilepsy; Mexico; Pharmaco | 1964 |
[CLINICAL EXPERIENCES WITH VALIUM ROCHE, A NEW BENZODIAZEPINE DERIVATIVE].
Topics: Antisocial Personality Disorder; Anxiety; Anxiety Disorders; Autonomic Nervous System Diseases; Benz | 1964 |
DIAZEPAM (VALIUM) IN MYOCLONIC SEIZURES. FAVORABLE RESPONSE DURING INFANCY AND CHILDHOOD.
Topics: Anticonvulsants; Child; Diazepam; Drug Therapy; Electroencephalography; Epilepsies, Myoclonic; Epile | 1965 |
THE LONG-TERM USE OF VALIUM.
Topics: Depression; Depressive Disorder; Diazepam; Drug Therapy; Epilepsy; Intellectual Disability | 1965 |
TOXIC PSYCHOSIS WITH TRANSIENT DYSMNESTIC SYNDROME FOLLOWING WITHDRAWAL FROM VALIUM.
Topics: Chlorpromazine; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; Hallucinations; Humans; Memory; Psychose | 1965 |
LONG TERM CLINICAL TRIAL WITH DIAZEPAM ON ADULT MENTALLY RETARDED PERSONS.
Topics: Adult; Brain; Brain Damage, Chronic; Diazepam; Drug Therapy; Epilepsy; Epilepsy, Absence; Epilepsy, | 1965 |
TREATMENT OF STATUS EPILEPTICUS WITH DIAZEPAM (VALIUM).
Topics: Adolescent; Barbiturates; Child; Diazepam; Drug Therapy; Electrocardiography; Electroencephalography | 1965 |
Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice.
Topics: Animals; Anticonvulsants; Bicuculline; Convulsants; Dehydroepiandrosterone Sulfate; Diazepam; Dose-R | 2004 |
Treatment and outcome in patients with febrile convulsion associated with epileptiform discharges on electroencephalography.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Drug Administration Schedule; Electroencephalography; E | 2004 |
Suppression of fully kindled seizure and retardation of kindling acquisition by YM928 in the rat kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Electrodes, Implanted; Electro | 2004 |
[A case of advanced rhabdomyosarcoma of the spermatic cord who occurred epilepsy-like symptoms, but was completely responded to chemotherapy].
Topics: Adult; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Diazepam; Epileps | 2004 |
Acute effect of an extract of Ambrosia paniculata (Willd.) O. E. Schultz (mugwort) in several models of experimental epilepsy.
Topics: Ambrosia; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cerebral Cortex; Diazepa | 2004 |
Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats.
Topics: Animals; Anticonvulsants; Benzoquinones; Convulsants; Diazepam; Epilepsy; Flumazenil; Injections, In | 2005 |
Respiratory adverse events associated with diazepam rectal gel.
Topics: Administration, Rectal; Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Drug Interactions | 2005 |
[Epileptic seizures during childbirth in a patient with idiopathic generalised epilepsy].
Topics: Adult; Anticonvulsants; Cesarean Section; Clonazepam; Diazepam; Epilepsy; Epilepsy, Generalized; Epi | 2005 |
Rectal diazepam gel in the home management of seizures in children.
Topics: Administration, Rectal; Anticonvulsants; Child; Child, Preschool; Diazepam; Emergency Service, Hospi | 2005 |
Ictal monoparesis associated with lesions in the primary somatosensory area.
Topics: Adult; Arm; Brain Damage, Chronic; Brain Neoplasms; Cerebral Angiography; Cerebral Veins; Diazepam; | 2005 |
Spike-wave stupor in a patient with metabolic encephalopathy.
Topics: Ammonia; Anticonvulsants; Brain Diseases, Metabolic; Coma; Diagnosis, Differential; Diazepam; Electr | 2007 |
Anticonvulsant properties of hypothermia in experimental status epilepticus.
Topics: Animals; Anticonvulsants; Body Temperature; Brain; Cold Temperature; Dentate Gyrus; Diazepam; Diseas | 2006 |
Effects of diazepam on 125I-iomazenil-benzodiazepine receptor binding and epileptic seizures in the El mouse.
Topics: Animals; Anticonvulsants; Autoradiography; Brain; Diazepam; Disease Models, Animal; Epilepsy; Flumaz | 2006 |
[Epilepsy: which therapy in acute care?].
Topics: Acute Disease; Anticonvulsants; Benzodiazepines; Clobazam; Clonazepam; Diazepam; Epilepsy; Humans; L | 2006 |
Audit of the use of buccal diazepam at a residential centre for children with epilepsy.
Topics: Administration, Buccal; Adolescent; Adult; Anticonvulsants; Diazepam; Epilepsy; Female; Hospitals, C | 2007 |
Sleep-related epilepsy in the A/J mouse.
Topics: Alleles; Animals; Anticonvulsants; Chromosomes, Mammalian; Diazepam; Disease Models, Animal; Electro | 2007 |
Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs.
Topics: Anticonvulsants; Astrocytes; Blood-Brain Barrier; Brain; Cells, Cultured; Coculture Techniques; Diaz | 2007 |
Early diffusion-weighted MRI predicts regional neuronal damage in generalized status epilepticus in rats treated with diazepam.
Topics: Animals; Anticonvulsants; Brain; Brain Damage, Chronic; Convulsants; Diazepam; Diffusion; Diffusion | 2007 |
Loss of input from the mossy cells blocks maturation of newly generated granule cells.
Topics: Animals; Anticonvulsants; Biomarkers; Bromodeoxyuridine; Calbindin 2; Cell Differentiation; Cell Pro | 2007 |
School nurses' experience with administration of rectal diazepam gel for seizures.
Topics: Administration, Rectal; Anticonvulsants; Child; Diazepam; Emergencies; Epilepsy; Gels; Health Care S | 2007 |
AMPA receptor activation reduces epileptiform activity in the rat neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anim | 2007 |
Acceptance of the use of diazepam rectal gel in school and day care settings.
Topics: Administration, Rectal; Adolescent; Anticonvulsants; Child; Child Day Care Centers; Child, Preschool | 2007 |
Treatment of refractory seizures due to a benign mass present in the corpus callosum with an ion magnetic inductor: case report.
Topics: Adult; Agenesis of Corpus Callosum; Anticonvulsants; Colchicine; Combined Modality Therapy; Corpus C | 2005 |
Funny turns in an elderly man.
Topics: Age Factors; Aged; Anticonvulsants; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Male; Recur | 2007 |
Sedative and anticonvulsant effects of zolpidem in adult and aged mice.
Topics: Age Factors; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Disease Models, Animal; Dose-Re | 2008 |
[Postictal paranoid-hallucinatory psychosis in cryptogenic epilepsy].
Topics: Acute Disease; Adult; Anticonvulsants; Cooperative Behavior; Delusions; Diazepam; Epilepsy; Epilepsy | 2007 |
[Progressive myoclonus epilepsy with Lafora bodies. Clinical and polygraphic study. Anatomical ultrastructural verification].
Topics: Adolescent; Brain; Cytoplasmic Granules; Diazepam; Electrocardiography; Electroencephalography; Elec | 1967 |
Pharmacokinetics of benzodiazepines and psychostimulants in children.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Attention Deficit Disorder with Hyperactivity; Biotransforma | 1983 |
Pharmacology of methyl- and propyl-beta-carbolines in a hereditary model of epilepsy.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Carbolines; Chickens; Convulsants; Diazepam; Epilepsy | 1984 |
Antiepileptic effect and serum levels of clorazepate on children with refractory seizures.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Child; Child, Preschool; Clorazepate Dipota | 1984 |
Correlations between EEG changes induced by diazepam and the localization of epileptic spikes and seizures.
Topics: Adult; Brain; Diazepam; Electroencephalography; Epilepsy; Evoked Potentials; Humans | 1982 |
[Antiepileptic effects of synthetic pharmacologic agents and vitamin preparations used in combination].
Topics: Animals; Anticonvulsants; Crosses, Genetic; Diazepam; Drug Therapy, Combination; Epilepsy; Mice; Mic | 1984 |
Brain benzodiazepine receptors and their rapid changes after seizures in the Mongolian gerbil.
Topics: Animals; Binding Sites; Brain; Diazepam; Disease Models, Animal; Epilepsy; Gerbillinae; Receptors, D | 1980 |
Rectal diazepam: a clinical and EEG study after a single dose in children.
Topics: Adolescent; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsies, Myoclonic; Epilep | 1983 |
Active metabolites in antiepileptic therapy. Reflections on a pharmacological joker.
Topics: Anticonvulsants; Biotransformation; Carbamazepine; Diazepam; Epilepsy; Humans; Kinetics; Primidone; | 1983 |
Maprotiline hydrochloride associated with a clinical state of catatonic stupor and epileptic encephalogram.
Topics: Anthracenes; Catatonia; Depressive Disorder; Diazepam; Drug Therapy, Combination; Electroencephalogr | 1984 |
Case report: psychomotor status-like episodes under haloperidol treatment.
Topics: Adult; Diazepam; Epilepsy; Haloperidol; Humans; Male; Schizophrenia | 1984 |
Prophylaxis and febrile convulsions.
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Se | 1981 |
Serum protein binding of diazepam and its displacement by valproic acid in vitro.
Topics: Binding, Competitive; Diazepam; Epilepsy; Humans; In Vitro Techniques; Serum Albumin; Valproic Acid | 1981 |
Pharmacokinetics of diazepam in epileptic patients and normal volunteers following intravenous administration.
Topics: Adult; Diazepam; Epilepsy; Half-Life; Humans; Injections, Intravenous; Male; Nordazepam | 1981 |
["Fever convulsions" in children. Current viewpoints on diagnosis, therapy and prognosis].
Topics: Child, Preschool; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Parents; Phenobarbita | 1982 |
A study of the action of anticonvulsant drugs on an experimental model of epilepsy.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Electric Stimulation; Epi | 1980 |
Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors.
Topics: Amygdala; Animals; Benzodiazepines; Cerebral Cortex; Diazepam; Disease Models, Animal; Electroshock; | 1980 |
Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Diazepam; Epilepsy; Female; Humans | 1982 |
Rectal absorption of diazepam in epileptic children.
Topics: Adolescent; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Intestinal Absorption; Rect | 1982 |
Some practical hints and management of convulsions occurring in infancy and children.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Fever; Humans; Infant; Infant, Newborn; Seizu | 1981 |
The anticonvulsant effects of diazepam and phenobarbital in prekindled and kindled cortical seizures.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Disease Models, Animal; Epilepsy; Mal | 1981 |
[Systems relations in neuropathology and psychiatry (various problems in treatment)].
Topics: Central Nervous System; Chorea; Diazepam; Epilepsy; Humans; Mental Disorders; Nervous System Disease | 1981 |
Wall-coated open tubular column coupled with nitrogen-selective detector for routine GLC determination of diazepam, meprobamate, phenylbutazone, and thioridazine in serum.
Topics: Adolescent; Adult; Child; Chromatography, Gas; Diazepam; Epilepsy; Female; Humans; Male; Meprobamate | 1980 |
[Paroxysmal dyskinesia during treatment with diphenylhydantoin].
Topics: Adult; Brain Diseases; Child; Child, Preschool; Diazepam; Dyskinesia, Drug-Induced; Epilepsy; Female | 1980 |
Febrile seizures: long-term management of children with fever-associated seizures. Summary of an NIH consensus statement.
Topics: Child, Preschool; Diazepam; Epilepsy; Fever; Humans; Infant; Phenobarbital; Risk; Seizures; Seizures | 1980 |
Dynamic study of the acoustico-facial reflex by impedance measurement.
Topics: Acoustic Impedance Tests; Aging; Auditory Fatigue; Diazepam; Epilepsy; Humans; Hyperacusis; Loudness | 1980 |
Extending the indications of registered drugs: rectal diazepam in epilepsy.
Topics: Administration, Rectal; Anticonvulsants; Australia; Diazepam; Drug Approval; Epilepsy; Humans | 1995 |
Airline policy relating to passengers with epilepsy.
Topics: Aerospace Medicine; Diazepam; Epilepsy; Humans; Organizational Policy; Surveys and Questionnaires | 1995 |
Position statement on the use of rectal diazepam in epilepsy. Epilepsy Society of Australia, the Child Neurology Study Group, the Australian Association of Neurologists, and the National Epilepsy Association of Australia.
Topics: Administration, Rectal; Anticonvulsants; Australia; Child; Diazepam; Emergencies; Epilepsy; Home Nur | 1995 |
Oral flumazenil in the treatment of epilepsy.
Topics: Administration, Oral; Clinical Trials as Topic; Diazepam; Drug Therapy, Combination; Epilepsy; Epile | 1995 |
Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats.
Topics: Animals; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy; Hippocampus; Histocytochemistr | 1995 |
Benzodiazepines promote the intermediate stage at the expense of paradoxical sleep in the rat.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Electroencephalography; Epilepsy; Eye Movements; Heart Rate; | 1994 |
Kainate-induced apoptotic cell death in hippocampal neurons.
Topics: Animals; Apoptosis; Cell Nucleus; Diazepam; DNA; Electrophoresis, Polyacrylamide Gel; Epilepsy; Hipp | 1994 |
Rectal administration of diazepam.
Topics: Administration, Rectal; Cardiopulmonary Resuscitation; Diazepam; Epilepsy; Humans; Respiratory Insuf | 1994 |
Epilepsy treatment in The Netherlands. Comparison of matched groups of two medical centres.
Topics: Adolescent; Adult; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Female; gamma-Aminobutyric Acid; | 1994 |
[Diazepam-induced EEG changes as a predictor of the outcome of epilepsy].
Topics: Clonazepam; Diazepam; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Male; Pro | 1993 |
Status epilepticus: management and outcome of 107 episodes.
Topics: Adolescent; Adult; Aged; Chlormethiazole; Clinical Protocols; Diazepam; Epilepsy; Female; Humans; In | 1994 |
Excitatory amino acid antagonists, lamotrigine and BW 1003C87 as anticonvulsants in the genetically epilepsy-prone rat.
Topics: 2-Amino-5-phosphonovalerate; Acoustic Stimulation; Amino Acids; Amino Acids, Cyclic; Analysis of Var | 1993 |
The need for guidelines on the use of rectal diazepam.
Topics: Administration, Rectal; Adult; Child; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; First Aid; Humans; | 1993 |
Diazepam to prevent febrile seizures.
Topics: Child; Diazepam; Electroencephalography; Epilepsy; Humans; Seizures, Febrile | 1993 |
Neurophysiologic and clinical correlations of epileptic nystagmus.
Topics: Adult; Aged; Child; Consciousness; Diazepam; Electroencephalography; Epilepsy; Eye Movements; Female | 1993 |
[Drug therapy and its problems in epilepsy].
Topics: Clonazepam; Diazepam; Emergencies; Epilepsy; Humans | 1993 |
The prognostic significance of diazepam-induced EEG changes in epilepsy: a follow-up study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Beta Rhythm; Child; Clonazepam; Diazepam; Drug Therapy, Co | 1993 |
[Five cases of paroxysmal sleep disturbances].
Topics: Carbamazepine; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencephalography; E | 1993 |
Modifications of diazepam binding inhibitor and peripheral benzodiazepine receptors in the lymphocytes of epileptic patients.
Topics: Adolescent; Carbamazepine; Child; Diazepam; Epilepsy; Female; Humans; Lymphocytes; Male; Receptors, | 1996 |
Early clinical and EEG features of infantile spasms in Down syndrome.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Comorbidity; Diazepam; Down Syndrome; Elect | 1996 |
Tolerance to anticonvulsant effects of some benzodiazepines in genetically epilepsy prone rats.
Topics: Acoustic Stimulation; Administration, Oral; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiaz | 1996 |
Effects of diazepam on fentanyl-induced epileptoid EEG activity and increase of multineuronal firing in limbic and mesencephalic brain structures.
Topics: Animals; Cats; Diazepam; Electroencephalography; Epilepsy; Fentanyl; Limbic System; Male; Mesencepha | 1996 |
Diazepam--its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cell Count; Convulsants; Diazepam; | 1997 |
Blockade of spreading depression in chronic epileptic rats: reversion by diazepam.
Topics: Animals; Anticonvulsants; Chronic Disease; Cortical Spreading Depression; Diazepam; Electroencephalo | 1997 |
[Epileptic seizures in children: acupressure instead of diazepam!. Interview by Elisabeth Moosmann M.A..].
Topics: Acupressure; Anticonvulsants; Child; Diazepam; Epilepsy; Humans | 1997 |
Local perfusion of diazepam attenuates interictal and ictal events in the bicuculline model of epilepsy in rats.
Topics: Administration, Topical; Animals; Bicuculline; Cerebral Cortex; Diazepam; Disease Models, Animal; Do | 1997 |
Cerebral perfusion SPECT imaging in epileptic and nonepileptic seizures.
Topics: Adult; Anticonvulsants; Brain; Cerebrovascular Circulation; Delta Rhythm; Depression; Diagnosis, Dif | 1997 |
[Functional MRI employing diazepam; a proposal of neuropharmacological fMRI].
Topics: Anti-Anxiety Agents; Brain; Cerebrovascular Circulation; Diazepam; Epilepsy; gamma-Aminobutyric Acid | 1997 |
Studies on quantitative beta activity in EEG background changes produced by intravenous diazepam in epilepsy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Beta Rhythm; Cerebral Cortex; Child; Diazepam; Electroence | 1997 |
Status epilepticus and the late development of spontaneous seizures in the pilocarpine model of epilepsy.
Topics: Animals; Anticonvulsants; Brain Mapping; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy | 1996 |
Interictal and ictal activity in the rat cobalt/pilocarpine model of epilepsy decreased by local perfusion of diazepam.
Topics: Animals; Anticonvulsants; Cobalt; Diazepam; Disease Models, Animal; Electroencephalography; Epilepsy | 1997 |
BW1003C87, phenytoin and carbamazepine elevate seizure threshold in the rat amygdala-kindling model of epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 1997 |
Gaining a perspective on childhood seizures.
Topics: Administration, Rectal; Adult; Child; Diazepam; Epilepsy; Humans; Recurrence; Seizures, Febrile | 1998 |
[Potentiation of the efficacy of anticonvulsant diazepam by electrostimulation of the cerebellar cortex].
Topics: Action Potentials; Animals; Anticonvulsants; Cats; Cerebellar Cortex; Convulsants; Diazepam; Electri | 1998 |
Dynamic regulation of the activated, autophosphorylated state of Ca2+/calmodulin-dependent protein kinase II by acute neuronal excitation in vivo.
Topics: Animals; Antibody Specificity; Anticonvulsants; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 1998 |
Who cares for students with epilepsy in mainstream education?
Topics: Administration, Rectal; Caregivers; Child; Child, Preschool; Diazepam; England; Epilepsy; Humans; Pi | 1998 |
Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbolines; Convulsants; Diazepam; Disease Mod | 1998 |
Pharmacoeconomic considerations in treatment options for acute seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Cost-Benefit Analysis; Diazepam; Economics, Pharmaceutical | 1998 |
Chronic phenobarbital therapy reduces plasma benzodiazepine concentrations after intravenous and rectal administration of diazepam in the dog.
Topics: Administration, Oral; Administration, Rectal; Animals; Anticonvulsants; Benzodiazepines; Diazepam; D | 1998 |
PNU-151774E protects against kainate-induced status epilepticus and hippocampal lesions in the rat.
Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Diazepam; Epilepsy; Hippocampus; Kainic Acid; Lamot | 1998 |
Treatment of acute repetitive seizures.
Topics: Administration, Rectal; Adult; Child; Clinical Trials as Topic; Diazepam; Epilepsy; Ethics, Medical; | 1998 |
Buccal midazolam and rectal diazepam for epilepsy.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Anti-Anxiety Agents; Anticonvulsants; Ch | 1999 |
Buccal midazolam and rectal diazepam for epilepsy.
Topics: Administration, Buccal; Administration, Intranasal; Administration, Rectal; Anti-Anxiety Agents; Ant | 1999 |
Buccal midazolam and rectal diazepam for epilepsy.
Topics: Administration, Buccal; Administration, Rectal; Adolescent; Anti-Anxiety Agents; Anticonvulsants; Ch | 1999 |
Technical report: treatment of the child with simple febrile seizures.
Topics: Analgesics, Non-Narcotic; Anticonvulsants; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phe | 1999 |
Rectal diazepam: pitfalls of excessive use in refractory epilepsy.
Topics: Administration, Rectal; Adolescent; Adult; Diazepam; Epilepsy; Female; Humans; Male; Risk Factors | 1999 |
Prehospital management of the seizure patient.
Topics: Adolescent; Adult; Airway Obstruction; Anticonvulsants; Child; Diazepam; Emergency Medical Technicia | 1999 |
Home and hospital treatment of acute seizures in children with nasal midazolam.
Topics: Acute Disease; Administration, Rectal; Adolescent; Anticonvulsants; Child; Child, Preschool; Diazepa | 1999 |
The effect of a novel pentadecapeptide BPC 157 on development of tolerance and physical dependence following repeated administration of diazepam.
Topics: Amino Acid Sequence; Animals; Anti-Ulcer Agents; Anticonvulsants; Antitubercular Agents; Brain Chemi | 1999 |
[Dupuytren's and Ledderhose's diseases associated with chronic use of anticonvulsants. Case report].
Topics: Adult; Anticonvulsants; Diazepam; Dupuytren Contracture; Epilepsy; Foot Diseases; Humans; Male; Phen | 1999 |
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
Topics: Acoustic Stimulation; Alprazolam; Animals; Anti-Anxiety Agents; Cognition; Conflict, Psychological; | 2000 |
An automated drug delivery system for focal epilepsy.
Topics: Animals; Anticonvulsants; Automation; Behavior, Animal; Diagnosis, Computer-Assisted; Diazepam; Drug | 2000 |
Previous experience of withdrawal from chronic diazepam ameliorates the aversiveness of precipitated withdrawal and reduces withdrawal-induced c-fos expression in nucleus accumbens.
Topics: Amygdala; Animals; Avoidance Learning; Conditioning, Psychological; Corpus Striatum; Diazepam; Epile | 2000 |
Role of ketamine in convulsions.
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Therap | 1999 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy | 2000 |
Long-term reduction of benzodiazepine receptor density in the rat cerebellum by acute seizures and kindling and its recovery 6 months later by a pentylenetetrazole challenge.
Topics: Acute Disease; Aging; Animals; Cerebellum; Convulsants; Diazepam; Drug Administration Schedule; Epil | 2001 |
Trimethylolpropane phosphate induces epileptiform discharges in the CA1 region of the rat hippocampus.
Topics: Action Potentials; Animals; Baclofen; Bridged Bicyclo Compounds, Heterocyclic; Convulsants; Diazepam | 2001 |
[Treatment with antiepileptic agents in patients with mental retardation and multiple handicaps].
Topics: Anticonvulsants; Antipsychotic Agents; Diazepam; Disabled Persons; Epilepsy; Humans; Intellectual Di | 2001 |
Enhanced anticonvulsant activity of neuroactive steroids in a rat model of catamenial epilepsy.
Topics: Allosteric Regulation; Animals; Anticonvulsants; Benzodiazepinones; Desoxycorticosterone; Diazepam; | 2001 |
Evidence for an involvement of the ammonia-decreasing action of L-arginine in suppressing picrotoxin-induced convulsions in rats and its additive action with diazepam.
Topics: Ammonia; Animals; Arginine; Brain; Diazepam; Drug Interactions; Epilepsy; GABA Antagonists; GABA Mod | 2001 |
The use of antiepileptic drugs in learning disabled people with epilepsy: an audit of adult in-patients in a treatment and continuing care service.
Topics: Adult; Anticonvulsants; Brain; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Learning | 2001 |
Two different mechanisms of disinhibition produced by GABAA receptor mutations linked to epilepsy in humans.
Topics: Cells, Cultured; Diazepam; Dose-Response Relationship, Drug; Electric Conductivity; Epilepsy; GABA M | 2002 |
[Adverse effects of anti-epileptic drugs].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Ethos | 1975 |
Proceedings: Aetiopathogenetic diagnosis of epilepsies. Influence of thiopental and diazepam on EEG epileptic phenomena.
Topics: Diagnosis, Differential; Diazepam; Epilepsy; Humans; Thiopental | 1975 |
How doctors deal with epilepsy.
Topics: Adolescent; Adult; Aged; Automobile Driving; Diazepam; Drug Therapy, Combination; Electroencephalogr | 1977 |
Intracranial pressure in childhood convulsions.
Topics: Cerebrovascular Circulation; Child; Child, Preschool; Diazepam; Diuretics, Osmotic; Epilepsy; Humans | 1979 |
[Clinical picture and basis for treating brain stem epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Brain Stem; Diazepam; Epilepsies, Myoclonic; Epilepsy; Female; H | 1978 |
Seizure activity and anticonvulsant drug concentration.
Topics: Anticonvulsants; Child; Circadian Rhythm; Diazepam; Dose-Response Relationship, Drug; Drug Administr | 1975 |
[Effect of drugs on electroclinical types of epileptic seizures in Lennox-Gastaut syndrome].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Barbiturates; Child; Child, Preschool; Clonazepam; Dia | 1977 |
Diagnostic and prognostic significance of electroencephalography with intravenous diazepam in epilepsy.
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Fe | 1979 |
[Drug therapy of epilepsy].
Topics: Anticonvulsants; Carbamazepine; Chlordiazepoxide; Clonazepam; Diazepam; Electroencephalography; Epil | 1975 |
Involuntary movements caused by phenytoin intoxication in epileptic patients.
Topics: Adult; Chlorpheniramine; Diazepam; Drug Interactions; Drug Therapy, Combination; Electroencephalogra | 1975 |
Monitoring diazepam and desmethyldiazepam concentrations in plasma by gas-liquid chromatography, with use of a nitrogen-sensitive detector.
Topics: Chromatography, Gas; Diazepam; Epilepsy; Humans; Microchemistry; Nitrogen; Nordazepam | 1979 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1979 |
Recent advances in drug therapy of some forms of childhood epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Clonazepam; Diazepam; Drug Therapy, Combination; Epilepsy; Hu | 1979 |
Epilepsy and pregnancy.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Blood Coagulation Disorders; Chromosome Aberrations; C | 1979 |
Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children.
Topics: Acute Disease; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Prospective Studies; Rectum; Se | 1979 |
Epileptiform seizures with maprotiline hydrochloride.
Topics: Adult; Anthracenes; Diazepam; Epilepsy; Female; Humans; Male; Maprotiline; Middle Aged | 1979 |
[Antiepileptic activity of clonazepam, a benzodiazepine antiepileptic (2). Antiepileptic effects of intravenous injection of clonazepam manifested in EEG].
Topics: Adolescent; Adult; Aged; Anticonvulsants; Benzodiazepinones; Child; Clonazepam; Diazepam; Electroenc | 1977 |
Re: "Troubles in medical academe": a clarification.
Topics: Amobarbital; Diazepam; Epilepsy; Heart Arrest; Humans | 1977 |
[Drug information. Therapeutic main group: antiepileptica - anticonvulsants. Benzodiazepine derivatives].
Topics: Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Humans | 1977 |
A teratological evaluation of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anencephaly; Anticonvulsants; Cleft Lip; Cleft Palate; Diazepam; Epilep | 1977 |
[Antiepileptic emergency therapy in the adult age].
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Phenobarbi | 1978 |
Action of anticonvulsants on pentylenetetrazol-induced epileptiform activity on invertebrate neurones (Helix aspersa).
Topics: Action Potentials; Amobarbital; Animals; Anticonvulsants; Diazepam; Epilepsy; Helix, Snails; In Vitr | 1978 |
Proposals on antiepileptic pharmacotherapy for use in developing countries.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Clonazepam; Developing Countries; Diazepam | 1976 |
Diseases of the central nervous system: Epilepsy.
Topics: Age Factors; Diazepam; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Eth | 1975 |
[Symptomatic treatment of epilepsy].
Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Phenobarbital; Phenytoin | 1977 |
Epileptic seizures induced by psychotropic drugs.
Topics: Adolescent; Adult; Aged; Birth Order; Brain Damage, Chronic; Chlorpromazine; Diazepam; Dose-Response | 1977 |
Letter: status epilepticus.
Topics: Diazepam; Epilepsy; Humans; Phenobarbital | 1976 |
[Use of the Soviet preparation methindione for injections in convulsive conditions].
Topics: Adult; Anticonvulsants; Diazepam; Drug Therapy, Combination; Epilepsy; Female; Hexobarbital; Humans; | 1976 |
Diazepam: intravenous infusion in the treatment of status epilepticus.
Topics: Benzoates; Chemical Precipitation; Diazepam; Drug Combinations; Drug Interactions; Epilepsy; Glucose | 1976 |
[Side reaction after lumbar myelography with dimer-x (author's transl)].
Topics: Adolescent; Adult; Diazepam; Epilepsy; Female; Humans; Iothalamic Acid; Lumbar Vertebrae; Male; Midd | 1976 |
Letter: Sodium valproate in the treatment of intractable childhood epilepsy.
Topics: Diazepam; Drug Therapy, Combination; Epilepsy; Phenobarbital; Phenytoin; Primidone; Pyridoxine; Vale | 1975 |
The influence of aldosterone and anticonvulsant drugs on electroencephalographic and clinical disturbances induced by the spirolactone derivative, potassium canrenoate.
Topics: Aldosterone; Animals; Anticonvulsants; Brain; Diazepam; Disease Models, Animal; Dogs; Electroencepha | 1975 |
Ictal laughter: a case report with clinical, cinefilm, and EEG observations.
Topics: Adolescent; Brain; Carbamazepine; Diazepam; Drug Therapy, Combination; Electroencephalography; Epile | 1975 |
Letter: Comments on a startling article: "loss of limb following intravenous diazepam".
Topics: Amputation, Surgical; Arm; Benzodiazepines; Diazepam; Epilepsy; Humans; Injections, Intra-Arterial; | 1975 |
Letter: Tranquillizers causing aggression.
Topics: Adult; Aggression; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Personality Disorders | 1975 |
Chlormethiazole in status epilepticus--three cases.
Topics: Adult; Chlormethiazole; Diazepam; Epilepsy; Female; Humans; Male; Phenobarbital; Phenytoin | 1975 |
The management of epilepsy.
Topics: Amobarbital; Anticonvulsants; Diazepam; Drug Therapy, Combination; Emergencies; Epilepsy; Humans; Ph | 1975 |
[Hypothermia treatment in intractable epilepsy].
Topics: Adolescent; Child; Diazepam; Epilepsy; Female; Humans; Hypothermia, Induced; Male | 1975 |
Photically induced epilepsy in Papio papio as a model for drug studies.
Topics: Acetylcholine; Animals; Carbamazepine; Clonazepam; Diazepam; Disease Models, Animal; Dopamine; Dose- | 1975 |
Status epilepticus.
Topics: Anesthesia, General; Anticonvulsants; Diazepam; Emergencies; Epilepsy; Humans; Injections, Intramusc | 1975 |
Respiratory failure as a seizure phenomenon. A case report.
Topics: Brain Edema; Diazepam; Epilepsy; Humans; Male; Middle Aged; Phenobarbital; Respiratory Insufficiency | 1975 |
Drugs for epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diazepam; Epilepsy; Ethosuximide; Humans; Phenobarbital; | 1976 |
[Visual and computer evaluation of diazepam-induced EEG changes in epilepsy for localization of epileptogenic lesion].
Topics: Adolescent; Adult; Child; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Male; Middle A | 1992 |
Tolerance to anticonvulsant effects of clobazam, diazepam, and clonazepam in genetically epilepsy prone rats.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepino | 1992 |
[Drug therapy in epilepsy].
Topics: Anticonvulsants; Diazepam; Epilepsy; Humans | 1992 |
Flumazenil as an anti-epileptic agent.
Topics: Diazepam; Drug Evaluation; Epilepsy; Flumazenil; Humans; Time Factors | 1991 |
Paroxysmal activity in the rabbit visual cortex induced by photostimulation.
Topics: Animals; Caffeine; Diazepam; Electroencephalography; Epilepsy; Pentylenetetrazole; Photic Stimulatio | 1991 |
Brahmighritham, an Ayurvedic herbal formula for the control of epilepsy.
Topics: Administration, Oral; Animals; Diazepam; Electroencephalography; Epilepsy; Injections, Intraperitone | 1991 |
PIVKA-II (protein induced by vitamin K absence-II) status in newborns exposed to anticonvulsant drugs in utero.
Topics: Adult; Anticonvulsants; Biomarkers; Diazepam; Epilepsy; Factor VII; Factor X; Female; Humans; Infant | 1991 |
Rapid diazepam introduction (venous or rectal) in childhood epilepsy: taxonomic and therapeutic considerations.
Topics: Administration, Rectal; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; | 1991 |
Diazepam and Ro 15-1788 increase absence epilepsy in WAG/Rij rats chronically exposed to diazepam.
Topics: Animals; Diazepam; Electroencephalography; Epilepsy; Flumazenil; Hypnotics and Sedatives; Male; Rats | 1990 |
[Therapeutic drug monitoring of clonazepam, nitrazepam and diazepam].
Topics: Age Factors; Biological Availability; Chromatography, Gas; Chromatography, High Pressure Liquid; Chr | 1990 |
Postnatal evolution of the gamma-aminobutyric acid/benzodiazepine receptor complex in a model of inherited epilepsy: the quaking mouse.
Topics: Aging; Animals; Brain; Brain Stem; Cerebellum; Diazepam; Diencephalon; Epilepsy; Flunitrazepam; gamm | 1989 |
Clinical and EEG response to anticonvulsants in neonatal seizures.
Topics: Anticonvulsants; Diazepam; Electroencephalography; Epilepsy; Humans; Infant, Newborn; Paraldehyde; P | 1989 |
Effects of diazepam and two beta-carbolines on epileptic activity and on EEG and behavior in rats with absence seizures.
Topics: Animals; Anticonvulsants; Appetite Depressants; Behavior, Animal; Carbolines; Diazepam; Electroencep | 1989 |
Phenytoin withdrawal and seizure frequency.
Topics: Adult; Carbamazepine; Diazepam; Drug Therapy, Combination; Epilepsy; Epilepsy, Temporal Lobe; Female | 1989 |
Kainic acid-induced seizures: potentiation by alpha-methyl-p-tyrosine.
Topics: alpha-Methyltyrosine; Animals; Clonidine; Diazepam; Dopamine; Epilepsy; Kainic Acid; Male; Methyltyr | 1989 |
The sz mutant hamster: a genetic model of epilepsy or of paroxysmal dystonia?
Topics: Animals; Cricetinae; Diazepam; Disease Models, Animal; Dystonia; Electroencephalography; Electromyog | 1989 |
[Some suggestions on epileptic psychoses, their differential diagnosis and therapy].
Topics: Anticonvulsants; Antipsychotic Agents; Clonazepam; Dementia; Diagnosis, Differential; Diazepam; Drug | 1986 |
Possible destruction of cholinoceptive neurons by overstimulation of cholinergic tracts.
Topics: Animals; Brain; Choline O-Acetyltransferase; Cholinergic Fibers; Diazepam; Epilepsy; Flunitrazepam; | 1986 |
Oral benzodiazepines as prophylaxis for epilepsy.
Topics: Administration, Oral; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Clobazam; Clonazepam; | 1986 |
[Convulsive attacks and the dentist].
Topics: Adolescent; Child; Child, Preschool; Dental Care for Disabled; Diazepam; Emergencies; Epilepsy; Ging | 1988 |
Benzodiazepine receptors and seizure susceptibility in epileptic fowl.
Topics: Animals; Animals, Newborn; Brain Chemistry; Chickens; Diazepam; Epilepsy; Flunitrazepam; GABA Antago | 1985 |
[3H-diazepam binding to brain synaptic membranes during the development of generalized epileptic activity].
Topics: Animals; Bemegride; Brain; Diazepam; Epilepsy; Male; Rats; Rats, Inbred Strains; Receptors, Neurotra | 1985 |
Potent depressant action of baclofen on hippocampal epileptiform activity in vitro: possible use in the treatment of epilepsy.
Topics: Animals; Anticonvulsants; Baclofen; Carbamazepine; Diazepam; Epilepsy; gamma-Aminobutyric Acid; Guin | 1986 |
Treatment of epilepsy in infancy with special emphasis on ACTH therapy.
Topics: Administration, Rectal; Adrenocorticotropic Hormone; Diazepam; Dose-Response Relationship, Drug; Epi | 1986 |
Evaluation of CPP, a selective NMDA antagonist, in various rodent models of epilepsy. Comparison with other NMDA antagonists, and with diazepam and phenobarbital.
Topics: Amygdala; Animals; Anticonvulsants; Aspartic Acid; Diazepam; Electroshock; Epilepsy; Female; Gerbill | 1988 |
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; D | 1986 |
Serum concentrations of diazepam and its metabolite desmethyldiazepam in epileptic patients after chronic diazepam treatment.
Topics: Adult; Aged; Diazepam; Epilepsy; Humans; Middle Aged; Nordazepam | 1986 |
[Epilepsy induced by penicillin in rabbits: comparative study of the anticonvulsant effects of diazepam and chlordesmethyldiazepam].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Diazepam; Epilepsy; Male; Nordazepam | 1986 |
[Modification of psychophysical performance of the human by anticonvulsants].
Topics: Anticonvulsants; Arousal; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Mental Processes; | 1987 |
Benzodiazepine antagonist Ro 15-1788 (flumazepil) attenuates the anticonvulsant activity of diazepam in epileptic fowl.
Topics: Animals; Chickens; Diazepam; Epilepsy; Female; Flumazenil; Male; Poultry Diseases | 1987 |
Evaluation of the anticonvulsant and biochemical activity of CGS 8216 and CGS 9896 in animal models.
Topics: Animals; Anticonvulsants; Brain; Diazepam; Electric Stimulation; Epilepsy; gamma-Aminobutyric Acid; | 1988 |
Comparison of the effect of althesin with diazepam and thiopental sodium on cortical and subcortical epileptic activity in the rat.
Topics: Alfaxalone Alfadolone Mixture; Animals; Anticonvulsants; Cerebral Cortex; Diazepam; Electroencephalo | 1987 |
Agoraphobia and paroxysmal cerebral dysrhythmia.
Topics: Agoraphobia; Diazepam; Electroencephalography; Epilepsy; Humans; Phobic Disorders | 1987 |
Epileptic aphasia.
Topics: Aphasia; Brain; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Humans; Male | 1987 |
[Value of complamin and seduxen in the correction of hemodynamic disorders of epileptic children and adolescents].
Topics: Adolescent; Anticonvulsants; Brain; Cerebrovascular Disorders; Child; Diazepam; Drug Therapy, Combin | 1987 |
A case of parasomnia at REM sleep onset.
Topics: Adult; Anticonvulsants; Diagnosis, Differential; Diazepam; Dreams; Epilepsy; Humans; Male; Sleep Sta | 1987 |
Benzodiazepines in the treatment of children with epilepsy.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Child; Child, Preschool; Clobazam; Clonazep | 1986 |
A pharmacodynamic evaluation of midazolam as an antiepileptic compound.
Topics: Adult; Anticonvulsants; Diazepam; Drug Therapy, Combination; Epilepsy; Female; Humans; Injections, I | 1986 |
Anticonvulsant effects of ivermectin in genetically-epileptic chickens.
Topics: Animals; Anticonvulsants; Chickens; Diazepam; Epilepsy; Ivermectin; Mutation; Photic Stimulation; Po | 1986 |
Hypnogenic paroxysmal dystonia: epilepsy or sleep disorder? A case report.
Topics: Adult; Carbamazepine; Diazepam; Dystonia; Epilepsy; Humans; Male; Sleep; Sleep Wake Disorders; Syndr | 1985 |
Modification of strychnine epileptogenic focus in the brain cortex by diazepam.
Topics: Animals; Diazepam; Epilepsy; Male; Rats; Strychnine | 1985 |
[Convulsive crises in childhood].
Topics: Clonazepam; Crying; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Mi | 1985 |
Valium treatment in status epilepticus.
Topics: Brain; Diazepam; Electroencephalography; Epilepsy; Humans | 1971 |
Coarse features in epilepsy as a consequence of anticonvulsant therapy. Report of cases in two pairs of identical twins.
Topics: Acromegaly; Adult; Anticonvulsants; Carbamazepine; Child; Diazepam; Diseases in Twins; Epilepsy; Epi | 1973 |
[Calcium metabolism during antiepileptic therapy].
Topics: Adult; Alkaline Phosphatase; Anticonvulsants; Antipsychotic Agents; Calcium; Calcium Isotopes; Creat | 1973 |
Clonazepam (Ro 5-4023) in the treatment of myoclonus epilepsy. Four case reports.
Topics: Adult; Anticonvulsants; Benzodiazepinones; Chlorobenzenes; Diazepam; Drug Therapy, Combination; Elec | 1973 |
Phenytoin intoxication induced by sulthiame in epileptic patients.
Topics: Adolescent; Adult; Anticonvulsants; Chromatography, Gas; Diazepam; Epilepsy; Ethosuximide; Female; H | 1974 |
[COMPLARATIVE CHARACTERISTICS OF THE CLINICAL EFFECTS OF TRANQUILIZERS].
Topics: Anthracenes; Anti-Anxiety Agents; Benzoates; Benzodiazepinones; Chlordiazepoxide; Chlorobenzenes; Di | 1974 |
Epilepsy.
Topics: Adrenocorticotropic Hormone; Carbamazepine; Diazepam; Drug Hypersensitivity; Drug-Related Side Effec | 1974 |
Comparative anticonvulsant effect of several Librium analogs.
Topics: Chlordiazepoxide; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal | 1967 |
Intravenous diazepam in seizure disorders.
Topics: Diazepam; Electroencephalography; Epilepsy; Humans; Injections, Intravenous | 1967 |
Observations on two kinds of post-traumatic status epilepticus.
Topics: Accidents; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; H | 1967 |
Further studies of i.v. diazepam (Valium) and evoked potentials of photosensitive epileptic subjects and normal controls.
Topics: Cerebral Cortex; Diazepam; Electroretinography; Epilepsy; Evoked Potentials; Humans; Oculomotor Musc | 1967 |
Epilepsia partialis continua (EPC) and petit mal attacks observed in the same patient.
Topics: Adult; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Humans; Middle Aged | 1968 |
Electro-clinical aspects of acute intoxication with chloralose.
Topics: Acute Disease; Chloralose; Diazepam; Electroencephalography; Epilepsy; Humans; Myoclonus | 1968 |
Evoked potential studies in response to light in the baboon (Papio papio).
Topics: Animals; Cerebral Cortex; Chlorpromazine; Diazepam; Epilepsy; Evoked Potentials; Haplorhini; Light; | 1967 |
Demonstration by a screening method of the exceptional anti-convulsant properties of a new benzodiazepine.
Topics: Benzazepines; Diazepam; Epilepsy; Humans; Hypnotics and Sedatives; Seizures | 1969 |
Valium administration in status epilepticus and EEG follow-up.
Topics: Adult; Diazepam; Electroencephalography; Epilepsy; Humans | 1969 |
Effects of intravenous diazepam (valium) upon evoked potentials of photosensitive epileptic and normal subjects.
Topics: Adult; Cerebral Cortex; Diazepam; Electrocardiography; Electroencephalography; Electromyography; Ele | 1969 |
EEG changes after intravenous diazepam (Valium). A preliminary report.
Topics: Diazepam; Electroencephalography; Epilepsy; Humans; Injections, Intravenous | 1969 |
Intravenous diazepam (valium) as a deactivation test in epileptics.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; | 1969 |
Management of convulsions.
Topics: Child; Diazepam; Epilepsy; Humans; Phenobarbital; Seizures | 1970 |
Valium and epilepsy.
Topics: Animals; Child; Diazepam; Epilepsy; Haplorhini; Humans | 1970 |
Superiority of clonazepam over diazepam in experimental epilepsy.
Topics: Animals; Anticonvulsants; Bemegride; Benzazepines; Cats; Cobalt; Diazepam; Disease Models, Animal; E | 1973 |
Antiepileptic therapy and rickets in children.
Topics: Adolescent; Anticonvulsants; Barbiturates; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, To | 1973 |
Diagnosis and treatment of childhood myoclonic seizures.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain Damage, Chronic; Bromides; Child; Child, Preschool; | 1974 |
Diazepam treatment for acute convulsions in children. A report of 41 patients, three with plasma levels.
Topics: Adolescent; Age Factors; Brain Damage, Chronic; Brain Injuries; Child; Child, Preschool; Diazepam; E | 1974 |
Therapy of seizures in children.
Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Ethosuximide; Humans; Injections, Intramuscular; Injec | 1974 |
Prolonged trance-like stupor in epilepsy. Petit mal status-wave stupor, spaced-out status.
Topics: Adult; Behavior; Diagnosis, Differential; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Abse | 1974 |
Minor motor epilepsy--a denouement.
Topics: Age Factors; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant | 1970 |
The concentration of homovanillic and 5-hydroxyindoleacetic acids in ventricular and lumbar CSF. Studies in patients with extrapyramidal disorders, epilepsy, and other diseases.
Topics: Adolescent; Adult; Basal Ganglia Diseases; Cerebral Palsy; Cerebral Ventricles; Diazepam; Dihydroxyp | 1972 |
[Therapy of cerebral seizures in multiple-handicapped children].
Topics: Anticonvulsants; Barbiturates; Cerebral Palsy; Child; Child, Preschool; Diazepam; Disabled Persons; | 1973 |
[Diazepam in chronic epilepsy].
Topics: Chronic Disease; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Male; Middle Aged | 1967 |
[Current criteria of medical therapy of epilepsy].
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Child; Child, Preschool; Dexamethas | 1967 |
Drug treatment of convulsive disorders.
Topics: Acetazolamide; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Barbiturates; Child; Diazepam; E | 1972 |
Drug treatment of epilepsy in childhood.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Absence; Epil | 1969 |
A comprehensive scheme for the evaluation of anticonvulsant concentrations in blood using thin-layer chromatography.
Topics: Acetazolamide; Anticonvulsants; Benzazepines; Carbamazepine; Chlordiazepoxide; Chromatography, Thin | 1971 |
[Neuroleptics, thymoleptics and tranquilizers in neurological therapy].
Topics: Basal Ganglia Diseases; Chlordiazepoxide; Chlorpromazine; Diazepam; Epilepsy; Extrapyramidal Tracts; | 1969 |
[Medical treatment of epilepsy].
Topics: Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Epilepsy; Ethosuximide; Humans; Hydantoins; | 1971 |
[Therapy of epilepsy. The causes and consequences of inadequate treatment].
Topics: Acridines; Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Barbiturates; Carbamazepine; Child | 1972 |
Anticonvulsant drugs. I. Patho-physiological and pharmacological aspects.
Topics: Acetates; Acetazolamide; Anticonvulsants; Carbamazepine; Diazepam; Dibenzazepines; Electroencephalog | 1972 |
Status epilepticus.
Topics: Diazepam; Epilepsy; Humans; Hypocalcemia; Hypoglycemia; Magnesium Deficiency; Paraldehyde; Phenobarb | 1974 |
[Effect of Faustan (diazepam) on the EEG of epileptics].
Topics: Adolescent; Adult; Child; Diazepam; Drug Evaluation; Electroencephalography; Epilepsy; Humans; Injec | 1974 |
[Considerations and research on febrile convulsions].
Topics: Anticonvulsants; Brain Diseases; Child, Preschool; Diagnosis, Differential; Diazepam; Electroencepha | 1974 |
Prescribing in pregnancy.
Topics: Carbimazole; Chlorpromazine; Diabetes Mellitus; Diazepam; Drug Prescriptions; Epilepsy; Female; Fetu | 1974 |
[Letter: Diazepam (Valium)].
Topics: Child; Diazepam; Drug Tolerance; Epilepsy; Humans; Infant; Injections, Intravenous | 1974 |
Editorial: Management of status epilepticus.
Topics: Barbiturates; Diazepam; Epilepsy; Humans; Paraldehyde; Phenytoin | 1974 |
Anticonvulsant drug-serum levels in psychiatric patients with seizure disorders. Effects of certain psychotropic drugs.
Topics: Chlorpromazine; Chromatography, Gas; Diazepam; Drug Interactions; Epilepsy; Humans; Mental Disorders | 1974 |
Penicillin-induced epileptogenic foci. I. Time course and the anticonvulsant effects of diphenylhydantoin and diazepam.
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Cerebral Ventricles; Diazepam; Dose-Response Relati | 1974 |
Diazepam as an oral long-term anticonvulsant for epileptic mental patients.
Topics: Amobarbital; Anticonvulsants; Diazepam; Epilepsy; Evaluation Studies as Topic; Female; Humans; Long- | 1972 |
The action of some anticonvulsant drugs on cobalt-induced epilepsy and on the bemegride threshold in alert cats.
Topics: Animals; Anticonvulsants; Bemegride; Carbamazepine; Cats; Cobalt; Diazepam; Electroencephalography; | 1972 |
Tonic status epilepticus precipitated by intravenous diazepam in a child with petit mal status.
Topics: Child; Diazepam; Epilepsy; Epilepsy, Absence; Female; Hemiplegia; Humans | 1972 |
[Fever convulsions].
Topics: Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Fever; Humans; Long-Term Care; | 1972 |
Electroencephalographic analysis of atropine coma.
Topics: Atropine; Barbiturates; Bipolar Disorder; Coma; Delirium; Diazepam; Electroencephalography; Epilepsy | 1972 |
[Diazepam Spofa-an anxiolytic agent with anticonvulsive and myorelaxant effects].
Topics: Anticonvulsants; Anxiety; Diazepam; Epilepsy; Humans; Neuromuscular Depolarizing Agents; Neurotic Di | 1973 |
[Convulsions in children].
Topics: Adolescent; Adult; Anticonvulsants; Birth Injuries; Brain Diseases; Brain Injuries; Child; Child, Pr | 1973 |
[Ambulatory extended care for the child with seizures].
Topics: Adolescent; Age Factors; Ambulatory Care; Child; Child, Preschool; Diazepam; Epilepsy; Ethosuximide; | 1973 |
Diazepam suppositories in prolonged convulsions.
Topics: Child; Diazepam; Epilepsy; Female; Humans; Suppositories | 1973 |
[Use of diazepam (Valium) as a supplementary diagnostic medium during electroencephalography for epilepsy].
Topics: Adolescent; Adult; Child; Diazepam; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Mid | 1973 |
Epileptic pain. An uncommon manifestation with localizing value.
Topics: Adenocarcinoma; Adult; Brain Neoplasms; Cerebral Angiography; Diazepam; Epilepsy; Female; Humans; Ma | 1973 |
Intravenous diazepam in status epilepticus: a correction.
Topics: Child; Diazepam; Epilepsy; Humans; Injections, Intravenous | 1973 |
[Differential diagnosis and emergency treatment of epileptic seizures].
Topics: Anticonvulsants; Arrhythmias, Cardiac; Diagnosis, Differential; Diazepam; Emergencies; Epilepsy; Hum | 1973 |
[Use of diazepam (Valium) as an auxillary diagnostic aid in electroencephalography of epilepsy].
Topics: Adolescent; Adult; Child; Diazepam; Electroencephalography; Epilepsy; Humans; Methods; Middle Aged | 1973 |
[Neuro-psychiatric evaluation of Clonazepam (Ro 5-4023) in epileptic patients].
Topics: Adolescent; Adult; Animals; Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Evaluation | 1973 |
Serum concentrations of diazepam in subjects with epilepsy.
Topics: Administration, Oral; Cerebral Cortex; Diazepam; Dose-Response Relationship, Drug; Electroencephalog | 1973 |
Diazepam as an anticonvulsant.
Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Male; Middle Aged | 1973 |
Loss of limb following intravenous diazepam.
Topics: Arm; Child, Preschool; Diazepam; Epilepsy; Hand; Humans; Injections, Intra-Arterial; Injections, Int | 1974 |
Emergency management of the patient with seizures. 1. Generalized status epilepticus.
Topics: Airway Obstruction; Anesthesia, General; Anticonvulsants; Blood Pressure Determination; Blood Specim | 1974 |
Abnormal scintiangiographic findings associated with seizure activity.
Topics: Adult; Cerebrovascular Circulation; Child; Diazepam; Epilepsy; Female; Humans; Male; Paraldehyde; Ra | 1974 |
Letter: Diazepam for management of seizures.
Topics: Diazepam; Epilepsy; Glucose; Humans; Infusions, Parenteral; Phlebitis; Sodium Chloride | 1974 |
Infants exposed in utero to antiepileptic drugs. A prospective study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Amitriptyline; Amniotic Fluid; Anticonvulsants; Chro | 1974 |
Pharmacology for the pediatrician. Noncompliance contributing to apparent drug failure in status epilepticus.
Topics: Anticonvulsants; Benzodiazepinones; Child; Chlorobenzenes; Diazepam; Epilepsy; Ethosuximide; Female; | 1974 |
Diazepam (valium) in the treatment of epilepsy. A report of fifty cases.
Topics: Adolescent; Adult; Anticonvulsants; Child; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal | 1965 |
Treatment of status epilepticus with diazepam.
Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Female; Huma | 1966 |
[On the treatment of the status epilepticus with diazepam (Valium). Experiences in 12 cases].
Topics: Adolescent; Adult; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Humans; Male; Mid | 1966 |
[Status elepticus].
Topics: Barbiturates; Diazepam; Epilepsy; Epilepsy, Tonic-Clonic; Humans; Phenytoin | 1967 |
[On the syndrome of progessive myoclonus epilepsy according to Lundborg. (A clinical course observation for fifteen years)].
Topics: Adult; Cachexia; Cerebellar Diseases; Dementia; Diazepam; Electroencephalography; Electromyography; | 1968 |
Dangers of treatment of status epilepticus with diazepam.
Topics: Adolescent; Adult; Aged; Cheyne-Stokes Respiration; Child; Diazepam; Drug Antagonism; Epilepsies, Pa | 1969 |
[Diagnosis and treatment of Unverricht-Lundborg type progressive myoclonic epilepsy].
Topics: Adult; Biopsy; Blood Chemical Analysis; Brain; Cerebrospinal Fluid; Diagnosis, Differential; Diazepa | 1968 |
Parenteral diazepam in status epilepticus.
Topics: Adolescent; Adult; Aged; Alcoholism; Brain Neoplasms; Child; Child, Preschool; Diazepam; Electroence | 1969 |
The long-term oral use of valium (diazepam) in epilepsy.
Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsies, Partial; E | 1969 |
Electroencephalographic studies on the anticonvulsive action of intravenous diazepam.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epile | 1970 |
Intravenous diazepam and its anticonvulsive action.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; | 1970 |
[Diazepam (Faustan) as a drug of choice for the treatment of status epilepticus and long-lasting attacks in childhood].
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Humans; Infa | 1970 |
Spike-wave stupor. Petit mal status.
Topics: Anticonvulsants; Child; Diazepam; Electroencephalography; Epilepsy; Epilepsy, Absence; Ethosuximide; | 1971 |
Diazepam in the treatment of childhood epilepsy.
Topics: Administration, Oral; Age Factors; Child; Child, Preschool; Diazepam; Drug Tolerance; Electroencepha | 1971 |
[Problems of treatment of epilepsy].
Topics: Anemia, Macrocytic; Anticonvulsants; Bromides; Diazepam; Drug Synergism; Epilepsy; Epilepsy, Tempora | 1971 |
[Results of treatment of epilepsy in children up to 14 years of age].
Topics: Adolescent; Age Factors; Barbiturates; Child; Child, Preschool; Diazepam; Drug Synergism; Electroenc | 1971 |
[Intravenous use of nitrazepam (Mogadan) in the treatment of epilepsy].
Topics: Administration, Oral; Benzazepines; Child; Child, Preschool; Diazepam; Electroencephalography; Epile | 1970 |
[Cerebral seizures (conclusion). 4. Therapy].
Topics: Adult; Anticonvulsants; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Epileps | 1971 |
[Injectable diazepam (Seduxen, Valium) in the treatment of recurrent epileptic seizures in childhood].
Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Injections, Int | 1972 |
[The problem of convulsions in children. Considerations on the use of diazepam by intravenous injection].
Topics: Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Infant; Infant, | 1972 |
Status epilepticus.
Topics: Anticonvulsants; Diazepam; Epilepsy; Humans; Paraldehyde | 1972 |
Minor epileptic status.
Topics: Brain Diseases; Child; Diagnosis, Differential; Diazepam; Epilepsy; Humans; Phenytoin; Primidone | 1972 |
[Therapy of epilepsy].
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Humans; Hydantoins; Primidone; Suc | 1972 |
[Convulsive seizure, an urgent therapeutic problem].
Topics: Age Factors; Child, Hospitalized; Child, Preschool; Diazepam; Emergencies; Epilepsy; Humans; Infant | 1972 |
Obstacle to pediatric therapy.
Topics: Age Factors; Child; Child, Preschool; Diazepam; Drug and Narcotic Control; Epilepsy; Humans; United | 1972 |
Epilepsy in multiple sclerosis.
Topics: Adolescent; Adult; Barbiturates; Basal Ganglia; Carbamazepine; Cerebral Cortex; Demyelinating Diseas | 1972 |
[Therapy of status epilepticus].
Topics: Adolescent; Anticonvulsants; Barbiturates; Child; Child, Preschool; Diazepam; Diuretics; Electroence | 1971 |
Sedation for the mentally handicapped dental patient.
Topics: Adolescent; Aggression; Anesthesia, Dental; Anesthesia, Local; Benperidol; Child; Child, Preschool; | 1971 |
[Value of benzodiazepins injected by the intravenous route].
Topics: Benzazepines; Brain Diseases; Diazepam; Electroencephalography; Epilepsy; Humans; Injections, Intrav | 1971 |
Diazepam for epilepsy.
Topics: Administration, Oral; Child; Diazepam; Electroencephalography; Epilepsy; Humans; Hypotension; Inject | 1971 |
[Experience in the use of seduxen in ampules in the treatment of epileptic status].
Topics: Adolescent; Adult; Diazepam; Epilepsy; Humans; Injections, Intramuscular; Injections, Intravenous; M | 1971 |
[Valium in the therapy of epileptic status].
Topics: Adult; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Injections, Intravenous; Male; Se | 1971 |
[Anticonvulsants. 2. Pharmacodynamics].
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Diazepam; Epilepsy; Humans; Hydantoins; Oxazoles; Prim | 1971 |
[Parenteral diazepam in the treatment of severe epilepsy].
Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Huma | 1971 |
[Therapeutic possibilities in the treatment of problem patients].
Topics: Adult; Anesthesia, Endotracheal; Child; Diazepam; Epilepsy; Humans; Hypnotics and Sedatives; Mental | 1968 |
New treatment for old neurologic disease. Status epilepticus treatment with diazepam.
Topics: Adult; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans | 1970 |
The effects of eserine and atropine on the epileptiform activity of chronically isolated cortex.
Topics: Acetylcholine; Animals; Atropine; Cats; Cerebral Cortex; Diazepam; Electroencephalography; Epilepsy; | 1971 |
Status epilepticus in infants and young children treated with parenteral diazepam.
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Infant, Newborn; Injections, In | 1969 |
[Demonstration of the exceptional anti-epileptic properties of a new benzodiazepine using a screening technic].
Topics: Administration, Oral; Anticonvulsants; Benzazepines; Diazepam; Electroencephalography; Epilepsy; Hum | 1969 |
[Experimental electrographic study comparing the anti-epileptic properties of a new benzodiazepine derivative the Ro 5-4023].
Topics: Anticonvulsants; Benzazepines; Brain; Chlordiazepoxide; Diazepam; Electroencephalography; Epilepsy; | 1969 |
[Therapy of epilepsy].
Topics: Activities of Daily Living; Anticonvulsants; Barbiturates; Diazepam; Electroencephalography; Epileps | 1969 |
The action of diazepam in neurological disorders with excessive motor activity.
Topics: Brain Diseases; Decerebrate State; Diazepam; Diencephalon; Electromyography; Epilepsy; Hemiplegia; H | 1970 |
Treatment of status epilepticus in dogs with diazepam sodium.
Topics: Animals; Barbiturates; Diazepam; Dog Diseases; Dogs; Epilepsy; Female; Injections, Intravenous; Male | 1970 |
[Therapy of epileptic mal states].
Topics: Diazepam; Epilepsy; Humans; Seizures | 1970 |
Valium in management of status epilepticus: a correction.
Topics: Diazepam; Epilepsy; Humans; Injections, Intravenous; Seizures | 1970 |
The effect of diazepam on the EEG of status epilepticus.
Topics: Adult; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Injections, Intravenous; Male; Mi | 1970 |
[Influencing of refractory epilepsies by deep cerebral hypothermia].
Topics: Adolescent; Adult; Child; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Hypothermia, I | 1970 |
General and local hypothermia of the brain in the treatment of intractable epilepsy.
Topics: Adolescent; Adult; Body Temperature; Child; Diazepam; Electroencephalography; Epilepsy; Female; Foll | 1970 |
Diazepam--the new wonder drug?
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant | 1970 |
Diazepam in the management of epilepsy.
Topics: Adult; Age Factors; Aged; Diazepam; Epilepsy; Female; Follow-Up Studies; Humans; Male; Middle Aged; | 1970 |
Gelastic epilepsy.
Topics: Adolescent; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Hyp | 1970 |
[The basic criteria for clinical evaluation of the effect of tranquilizers].
Topics: Benactyzine; Bipolar Disorder; Central Nervous System Diseases; Chlordiazepoxide; Diazepam; Epilepsy | 1970 |
[Status epilepticus].
Topics: Diazepam; Electroencephalography; Epilepsy; Humans; Phenytoin | 1970 |
Electroclinical aspects of remission of status epilepticus.
Topics: Adult; Alpha Rhythm; Automatism; Barbiturates; Cognition Disorders; Diazepam; Electroencephalography | 1970 |
[Seduxen treatment of status epilepticus].
Topics: Adolescent; Adult; Aged; Alcoholism; Craniocerebral Trauma; Diazepam; Electroencephalography; Epilep | 1971 |
[Electro-clinical aspects of acute poisoning by chloralose].
Topics: Acute Disease; Adolescent; Adult; Aspirin; Cerebral Cortex; Chloralose; Diazepam; Electroencephalogr | 1967 |
[Contribution of daizepam (valium) to the completion of cardiazolic activation in clinical electroencephalography].
Topics: Diazepam; Drug Synergism; Electroencephalography; Epilepsy; Humans; Pentylenetetrazole | 1967 |
[Injection of barbiturates in status epilepticus].
Topics: Barbiturates; Diazepam; Epilepsy; Humans; Injections, Intramuscular; Injections, Intravenous; Seizur | 1968 |
Remarks on the EEG and movement disorder in SSPE.
Topics: Brain; Cerebral Cortex; Child; Child, Preschool; Diagnosis, Differential; Diazepam; Diffuse Cerebral | 1968 |
E.C.T. phases with and without anaesthesia: a preliminary statistical study.
Topics: Amobarbital; Anesthesia; Diazepam; Electroconvulsive Therapy; Epilepsy; Humans; Methohexital; Reacti | 1968 |
Seduxen in neuropsychiatry.
Topics: Adolescent; Adult; Aged; Child; Diazepam; Epilepsy; Female; Hemiplegia; Humans; Male; Middle Aged; N | 1968 |
Recent advances in treating epileptic children.
Topics: Anticonvulsants; Child; Child, Preschool; Diazepam; Epilepsy; Ethosuximide; Humans; Quinacrine | 1968 |
The treatment of recurrent convulsions with intravenous injection of diazepam.
Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Diazepam; Epilepsy; Female; Humans; Injections, Int | 1968 |
[Changing of the photosensible threshold in the electroencephalogram by drugs acting in the central nervous system].
Topics: Adolescent; Adult; Aged; Barbiturates; Central Nervous System; Child; Diazepam; Electroencephalograp | 1968 |
[Comparative studies on the action profile of some benzodiazepine derivatives].
Topics: Anticonvulsants; Anxiety Disorders; Benzazepines; Chlordiazepoxide; Diazepam; Epilepsy; Humans; Hypn | 1968 |
[Treatment of infantile spasms with nitrazepam].
Topics: Adrenal Cortex Hormones; Anticonvulsants; Child, Preschool; Diazepam; Drug Synergism; Epilepsy; Huma | 1968 |
Status epilepticus and diazepam.
Topics: Diazepam; Drug Synergism; Epilepsy; Humans; Hypotension | 1969 |
The intravenous use of diazepam in focal status epilepticus.
Topics: Adult; Aged; Alcoholism; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Injections, Int | 1969 |
[Treatment of the condition of epilepsy in children by diazepam].
Topics: Adolescent; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Male | 1969 |
Medical therapy of epilepsy.
Topics: Anticonvulsants; Diazepam; Epilepsy; Ethosuximide; Humans; Succinimides | 1969 |
"Half and half" seizures.
Topics: Adolescent; Diazepam; Electroencephalography; Epilepsy; Humans; Male; Reflex | 1969 |
Effect of drugs on the somatosensory evoked potentials in myoclonic epilepsy.
Topics: Adult; Benzazepines; Diazepam; Electroencephalography; Epilepsy; Evoked Potentials; Humans; Male; Me | 1969 |
[The convulsive child].
Topics: Acute Disease; Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Infant, Newborn; Muscle | 1969 |
Diazepam: its scope in anaesthetic practice.
Topics: Adult; Amnesia; Anesthesia, Dental; Anesthesia, Obstetrical; Cardiac Catheterization; Cardiac Surgic | 1969 |
[Use in electroencephalographic practice of a rapid-acting injectable anticonvulsant (Diazepam)].
Topics: Diazepam; Electroencephalography; Epilepsy; Humans | 1965 |
[The action of diazepam (Valium) in the treatment of nonconvulsive forms of generalized epilepsy (absences and absence states of various types)].
Topics: Adolescent; Adult; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Male; Middle Aged | 1965 |
[Preliminary note on the effects of diazepam in epilepsy].
Topics: Adolescent; Child; Child, Preschool; Diazepam; Epilepsy; Female; Humans; Infant; Male | 1965 |
[Intravenous methyldiazepinone in an epileptic state appearing at the termination of anesthesia].
Topics: Adult; Diazepam; Epilepsy; Female; Humans; Injections, Intravenous; Postoperative Complications; Sei | 1965 |
[The treatment of status epilepticus with "diazepam". Clinical study and electroencephalographic documentation. Preliminary notes].
Topics: Adult; Child; Child, Preschool; Diazepam; Electroencephalography; Epilepsy; Female; Humans; Male | 1966 |
Tap seizures. A form of sensory precipitation epilepsy.
Topics: Birth Injuries; Child, Preschool; De Lange Syndrome; Diazepam; Electroencephalography; Electromyogra | 1966 |