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diazepam and Astrocytoma

diazepam has been researched along with Astrocytoma in 3 studies

Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.

Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)

Research Excerpts

ExcerptRelevanceReference
"The effects of several benzodiazepines (diazepam, clonazepam, Ro 15-1788 and Ro 5-4864) on cell proliferation of 2 human gliomas were estimated in vitro by means of [3H]-thymidine uptake assay."3.67Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro. ( Kunert-Radek, J; Pawlikowski, M; Radek, A; Stepien, H, 1988)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19903 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Syapin, PJ1
Skolnick, P1
Tempfer, H1
Pawlikowski, M1
Kunert-Radek, J1
Radek, A1
Stepien, H1

Other Studies

3 other studies available for diazepam and Astrocytoma

ArticleYear
Characterization of benzodiazepine binding sites in cultured cells of neural origin.
    Journal of neurochemistry, 1979, Volume: 32, Issue:3

    Topics: Animals; Astrocytoma; Cell Line; Cell Membrane; Cerebral Cortex; Diazepam; Glioma; Humans; Kinetics;

1979
[Jacksonian fits and threatened premature labour (the effect of valium, prepar and antiepileptic drugs on the fetus and uterine contractility ante and intra partum) (author's transl)].
    Wiener klinische Wochenschrift, 1975, Dec-12, Volume: 87, Issue:23

    Topics: Adult; Anticonvulsants; Astrocytoma; Diazepam; Epilepsies, Partial; Female; Fetus; Humans; Muscle Co

1975
Inhibition of cell proliferation of human gliomas by benzodiazepines in vitro.
    Acta neurologica Scandinavica, 1988, Volume: 77, Issue:3

    Topics: Astrocytoma; Benzodiazepines; Benzodiazepinones; Cell Division; Clonazepam; Diazepam; Female; Flumaz

1988